Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis

Eligibility criteria:
Inclusion Criteria:

          -  Patients with retina, glaucoma and neuroophthalmic disorders

          -  Patients with normal eye exams to act as controls

          -  Must be able to comprehend instructions and perform visual fields

        Exclusion Criteria:

          -  Patients <18years old

          -  Patients unable to comprehend visual field instructions or unwilling to participate

          -  Patients lacking a complete clinical file or lacking a specific diagnosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Effect of Neuromuscular Training on Osteoarthritis: A Comparative Prospective Randomized Study

Eligibility criteria:
Inclusion Criteria:

          -  radiographically assessed osteoarthritis of the knee graded 1 to 4 according to the
             Kellgren and Lawrence scale

          -  self reported moderate to severe level pain

        Exclusion Criteria:

          -  acute septic arthritis

          -  predisposition to a tendency to fall

          -  lack of physical or mental ability to perform or comply with the treatment procedure

          -  diabetes mellitus

          -  history of pathological osteoporotic fracture
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic knee osteoarthritis

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Isolation and Characterization of the Extracellular Vesicles Secreted by the Human Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women in natural cycles.

          -  Age: 18 to 35 years (both included).

          -  Normal karyotype.

          -  Negative serological results for HIV, HBV, HBC, RPR.

          -  BMI: 18-30 Kg/m2 (both included).

          -  Regular menstrual cycle (3-4/28-30 days).

        Exclusion Criteria:

          -  Patients who had carried a IUD device in the previous 3 months.

          -  Patients who had taken hormonal contraceptives in the previous 2 months.

          -  Adnexal or uterine pathologies.

          -  Polycystic ovary syndrome.

          -  Patients suffering from serious or uncontrolled bacterial, fungal or viral infectious
             diseases that could potentially interfere with the participation of the patient or
             with the results of the study (evaluated by the principal researcher of the research
             team).

          -  Any unstable disease or medical condition that could interfere with the study or put
             in risk the health of the patient (evaluated by the principal researcher of the
             research team).
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Sex Hormones & Serum Sclerostin Level

Eligibility criteria:
Inclusion Criteria:

          -  premenopausal women

          -  healthy

          -  volunteer

        Exclusion Criteria:

          -  Endocrinopathies

          -  Bone disease (osteoporosis, osteomalacia, paget disease etc)

          -  Women who used hormonal drug within last six months

          -  Cognitive disorders
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: CAVA: Dizziness Trial

Eligibility criteria:
Inclusion Criteria:

        Adults aged 18 and over.

          -  Patients experiencing episodes of true vertigo, with at least two episodes within the
             preceding month. Relevant medical conditions include Meniere's disease, Benign
             Paroxysmal Positional Vertigo (BPPV), recurrent vestibulopathy and vestibular
             migraine.

          -  Able to commit to 30 days of continuous wear of the trial device as per the study
             plan.

          -  Own a telephone.

        Exclusion Criteria:

          -  Potential participants who have a history of dermatological disease, fragile skin, or
             damage around the forehead.

          -  Potential participants who have an allergy to plasters and/or medical adhesives -
             (similarly to materials used in the device).

          -  History of hypertension or cardiac problems (uncontrolled, acute or de-compensated -
             phase).

          -  History of ear disease, or previous ear surgery.

          -  History of psychotic/neurotic disorders or epilepsy.

          -  History of eye disease, or previous eye surgery.

          -  Pregnant or nursing mothers.

          -  Potential participants who have taken part in a previous CAVA trial.

          -  Potential participants who are currently taking part in another trial.

          -  Unable to follow the testing protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Vasculitis Illness Perception (VIP) Study

Eligibility criteria:
Inclusion Criteria:

          -  Enrolled in VCRC Contact Registry

          -  Patient reported diagnosis of granulomatosis with polyangiitis (Wegener's
             granulomatosis), Microscopic Polyangiitis, Churg-Strauss Syndrome, Polyarteritis
             Nodosa, Giant Cell Arteritis, Takayasu's Arteritis, Henoch-Schöenlein Purpura, Behçets
             disease, and CNS Vasculitis

          -  18 years of age or older

          -  English speaking

        Exclusion Criteria:

          -  Inability to provide informed consent and complete survey
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Validity and Reliability of Smartphone Use in Measuring Joint Position Sense in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Patient must be referred to the outpatient clinic of the faculty of Physical Therapy
             and Medicine, Cairo University with a confirmed diagnosis of unilateral or bilateral
             osteoarthritis of the knee and having one or more of the following criteria (ASo,
             2000).

          -  Morning stiffness for less than 30 minutes.

          -  Crepitus on active knee movement.

          -  Bony enlargement either palpable or visible in radiographs.

          -  Bony tenderness at joint margins.

          -  Age 40-60 years old.

        Exclusion Criteria:

          -  Steroid injection within 2 months prior to inclusion.

          -  Presence of neurologic disorders (e.g., stroke, Parkinson's disease, or
             poliomyelitis). •Presence of other rheumatoid or orthopedic disorders in the lower
             extremity or spine. •A recent history of a lower extremity fracture with in the past
             year.

          -  History of ligament deficiency, such as anterior cruciate ligament or meniscal injury.

          -  Severe pain with active movement.

          -  Poor memory or cognitive function.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis

Eligibility criteria:
Inclusion Criteria:

          1. age 18 - 85 years,

          2. pleural effusion occupying more than one third of the hemithorax on the
             posteroanterior chest radiograph,

          3. therapeutic thoracentesis planned on the basis of signs and symptoms as well as
             imaging and functional studies,

          4. no contraindications for thoracentesis,

          5. signed informed consent for participation in the study.

        Exclusion Criteria:

          1. poor performance status requiring maximal shortening of the procedure,

          2. instable hemodynamic or respiratory status unrelated to pleural effusion,

          3. respiratory failure requiring mechanical ventilation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn

Eligibility criteria:
Inclusion Criteria:

          -  Experiencing heartburn in the past month if untreated

          -  Having heartburn that responds to heartburn medication

          -  Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
             in the study.

        Exclusion Criteria:

          -  Having history of erosive esophagitis or gastroesophageal reflux disease (GERD)
             diagnosed by a physician and confirmed by testing (endoscopy)

          -  Be unwilling to take only the study medication, and antacid provided as a rescue
             medication for relief of acute heartburn during the study.

        "Other protocol-defined inclusion/exclusion criteria may apply"
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment