Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation

Eligibility criteria:
Inclusion Criteria:

          -  Diarrhea

          -  constipation

        Exclusion Criteria:

          -  Shock

          -  Sepsis

          -  Past history with GI tract surgery

          -  Immunodeficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Months old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Early Pregnancy Failure: Factors Affecting Successful Medical Termination Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Crown rump length (CRL) is appropriate to less than 12 weeks.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Study of Fitusiran (ALN-AT3SC) in Severe Hemophilia A and B Patients With Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Males, ≥12 years of age

          -  Severe hemophilia A or B with inhibitors

               -  (Severity confirmed by a central laboratory where FVIII level is <1% or FIX level
                  is ≤2% at Screening; Inhibitors defined as inhibitor titer of ≥0.6 BU/mL or as
                  evidenced by medical records)

          -  A minimum of 6 bleeding episodes requiring bypassing agent treatment within the last 6
             months prior to Screening

          -  Willing and able to comply with the study requirements and to provide written informed
             consent and assent

        Exclusion Criteria:

          -  Known co-existing bleeding disorders other than hemophilia A or B

          -  Antithrombin (AT) activity <60% at Screening

          -  Co-existing thrombophilic disorder

          -  Clinically significant liver disease

          -  Active HCV infection

          -  HIV positive with a CD4 count of <200 cells/μL

          -  History of arterial or venous thromboembolism

          -  Inadequate renal function

          -  History of multiple drug allergies or history of allergic reaction to an
             oligonucleotide or N-Acetylgalactosamine (GalNAc)

          -  History of intolerance to SC injection(s)

          -  Any other conditions or comorbidities that would make the patient unsuitable for
             enrollment or could interfere with participation in or completion of the study, per
             Investigator judgement
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: NATural Ovarian Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  IVF-ET candidates (excluding PGD and oocyte donor);

          -  Body mass index from 18 to 30 kg/m2;

          -  Non smokers;

          -  Regular menstrual cycles (25-35 days);

          -  Presence of both ovaries;

          -  Antral follicle count (follicles measuring from 3 to 10 mm in diameter) ranging from
             10 to 30 on cycle days 2 to 4;

          -  Serum AMH levels ranging from 0.5 to 5.0 ng/mL;

          -  Normal endometrium at ultrasound (US) and/or hysteroscopy;

          -  Informed consent signed

        Exclusion Criteria:

          -  Iatrogenic ovarian insufficiency (surgery, radiotherapy, chemotherapy);

          -  Uterine abnormalities as demonstrated by pelvic US and/or hysteroscopy;

          -  Usual contra-indications for COH (cancer risk, blood coagulation disorders, etc)

          -  Renal insufficiency
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Validation of a Revised Version of the Danish McGill Ingestive Skills Assessment

Eligibility criteria:
Inclusion Criteria:

          -  Have a history of swallowing difficulties associated with aging and/or previous or
             current diagnosis of, but not limited to head and neck cancer (treatment may include
             surgery, radiation or chemotherapy, or a combination of more than one), stroke,
             cervical spine abnormality, brain tumor, cardiovascular surgery, Parkinson's disease
             or multi-morbidity.

               -  Fulfils five criteria for direct swallowing evaluation: able to remain alert for
                  at least 15 minutes; able to sit in a chair or bed in at least a 60° upright
                  position, able to swallow saliva, able to cough voluntarily, able to clear the
                  throat twice.

               -  Have the capacity to provide informed consent.

        Exclusion Criteria:

          -  The clients are excluded in case of: no dysphagia, known severe cognitive impairment,
             terminally illness (predicted survival less than 6 months), known contraindications to
             ingest foods or liquids, poorly controlled psychosis, inability to read consent form;
             inability or unwillingness to give written informed content.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Natural Cycles With Spontaneous Versus Induced Ovulation in FET

Eligibility criteria:
Inclusion Criteria:

          -  only single blastocyst transfer cycles were included

        Exclusion Criteria:

          -  PGT-a cycles and cleavage stage embryo transfers
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Impact of Large-Volume Pleural Effusions on Heart Function

Eligibility criteria:
Inclusion Criteria:

          1. the estimated amount of effusion is above 500 ml;

          2. Drainage was not performed within 1 month before admission;

          3. assigned informed consent.

        Exclusion Criteria:

          1. physical weakness which is difficult to withstand the thoracentesis;

          2. the happening of serious pleural reaction or reexpansion pulmonary edema on previous
             thoracentesis;

          3. allergy to the anesthetic;

          4. coagulation dysfunction, severe bleeding tendency;

          5. serious mental illness who do not cooperate;

          6. suspected with pleural hydatid disease;

          7. skin infection around supine positioning;

          8. severe heart function insufficiency who cannot lay on the back;

          9. for a variety of reasons that cannot accept regular follow-up;

         10. refused to sign the informed consent;

         11. other conditions that is not suitable for the test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
             at least three months

          -  Referred normal menses .Use of the same brand of sanitary protection wear for the
             whole of the period.

          -  BMI between 18 and 30

        Exclusion Criteria:

          -  Abnormal Bleeding Score

          -  Positive gynecological history of fibroids, polyps or malignancy

          -  Treatment with anti-coagulants, antifibrinolytics, non steroidal anti-inflammatory
             agents

          -  Use of oral contraceptives in past three months

          -  Use of intrauterine devices (IUDs) in past three months .Hgb levels <12 g/dl and
             Ferritin <25 ng/ml.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: 28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men

Eligibility criteria:
Inclusion criteria:

          -  Have a diagnosis of primary or secondary hypogonadism.

          -  Have very low testosterone levels on 2 separate days.

          -  Have a BMI within range of 18.5-35kg/m2.

          -  Have not taken dutasteride for one year, or finasteride for the past 3 months.

        Exclusion criteria:

          -  Have had or have breast or prostate cancer, malabsorption syndrome, sleep apnea,
             psychiatric illness, polycythemia, or any other clinically significant current
             condition.

          -  Are diabetic with an HbA1c >= 8.

          -  Are taking any androgens, such as testosterone, saw palmetto.

          -  Are taking ritonavir, indinavir, itraconazole, ketoconazole, erythromycin, warfarin,
             digoxin, cholestyramine, or any dietary/herbal/vitamin supplements.

          -  Would donate more than 500 ML of blood over a 2 month period.

          -  Physician does not think it is a good idea for you to participate in the trial. - Are
             unwilling to abstain from alcohol during the study.

          -  Have a positive urine drug screen test.

          -  Plan to change your smoking habits during the course of the trial.

          -  Have Hepatitis C, Hepatitis B, or HIV.

          -  Have a lab or EKG abnormality.

          -  High or low blood pressure.

          -  Have used of any investigational drug or device during the study or within 30 days
             prior to 1st dosing of study medication.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Quality of Pain Management at the Ziv Medical Center

Eligibility criteria:
Inclusion Criteria:

        Staff from the Ziv Medical Center and patients

        Exclusion Criteria:

        Staff members that do not deal with pain treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment