Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Revival of Stem Cells in Addison's Study

Eligibility criteria:
Inclusion Criteria:

          -  Established autoimmune adrenal failure for >1yr age 16 to 65

        Exclusion Criteria:

          -  Significant cardio-respiratory, chronic renal or non-autoimmune liver disease;
             malignancy

          -  Asthma, current infectious disease, recent live vaccination, acute psychosis, peptic
             ulcer disease

          -  Pregnancy, breast feeding or plan for pregnancy within 9 months

          -  Known non-autoimmune cause for adrenal failure (haemorrhage, adrenoleukodystrophy
             etc.)

          -  Known hypersensitivity or allergy to Synacthen
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 66 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of Sand Treatment on Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Joint pain related to daily activities;

          -  No morning joint stiffness greater than 30 minutes;

          -  Age between 30 and 95 years.

        Exclusion Criteria:

          -  History of previous knee surgery.

          -  History of fracture in the knee region.

          -  History of any secondary OA associated with any cystic arthropathy.

          -  Any treatment for the knee with methotrexate.

          -  History of hemorrhagic disorders.

          -  History of any infiltration of the knee during the previous 6 months (eg
             corticosteroids and hyaluronic acid).

          -  Morbid obesity.

          -  History of severe psychiatric disorders.

          -  History of skin cancer.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Two-stage Translation of the Chinese Version Menstrual Distress Questionnaire

Eligibility criteria:
Inclusion Criteria:

          1. A eumenorrheic healthy woman with a regular menstrual cycle for three months,
             predictable, and a period between 24-38 days that lasts less than 8 days.

          2. No hormonal contraceptives have been used in the past six months.

          3. No history of smoking, drinking or drug abuse.

        Exclusion Criteria:

          1. Women with systemic diseases, cardiovascular diseases, liver diseases, kidney
             diseases, diabetes or thyroid diseases.

          2. Taking any medicine due to chronic disease

          3. Women with mental illness
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Light Intensity Physical Activity Trial

Eligibility criteria:
Inclusion Criteria:

          -  40-70 years old

          -  having type 2 diabetes

          -  BMI 20-35 kg/m2

          -  having a sedentary lifestyle (i.e., self-reported moderate-to-vigorous physical
             activity < 150 minutes per week)

          -  willingness to undergo randomization

          -  being in the possession of personally owned smart phone

        Exclusion Criteria:

          -  not being able to walk for 15 minutes for any (medical) reason

          -  currently engaged in an (medical) exercise program

          -  plan to move out of the study area in the next 12 months

          -  (digital) illiteracy or being unable to read Dutch

          -  a history of any cardiovascular event (including stroke) three months prior to
             possible inclusion

          -  a history of signs or symptoms of ischemic heart disease and(or) heart failure three
             months prior to possible inclusion

          -  a history or signs or symptoms of peripheral arterial disease three months prior to
             possible inclusion

          -  a history or signs or symptoms of severe diabetic neuropathy or diabetic foot ulcers
             three months prior to possible inclusion

          -  a history of sign or symptoms of severe diabetic retinopathy three months prior to
             possible inclusion

          -  a history or sign or symptoms of severe osteoarthritis or severe joint complaints
             three months prior to possible inclusion

          -  a history or signs or symptoms of COPD (eligible are those participants with a COPD
             Gold classification ≤ I)

          -  uncontrolled diabetes (i.e., uncontrolled hypo- or hyperglycaemia)

          -  uncontrolled hypertension (i.e., systolic / diastolic blood pressure ≥ 180 / 95 mmHg)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 70 years or older.

          -  Family history of parent, brother, or sister who has, or had, serious age-related
             memory loss, senility, dementia, or Alzheimer's disease.

          -  Study partner available to provide information on the cognitive status of the
             participant and to assist with monitoring of trial medications, if needed.

          -  Sufficient fluency in written and spoken English to participate in study visits and
             neuropsychological testing.

          -  Willingness to limit use of the following for the duration of the study: vitamin E (at
             doses greater than 400 IU per day), non-aspirin NSAIDs, histamine H2 receptor
             antagonists (Tagamet, for example), corticosteroids, anti-inflammatory or analgesic
             doses of aspirin (greater than 81 mg per day), Ginkgo biloba extracts

          -  Ability and intention to participate in regular study visits, in the opinion of the
             study physician.

          -  Provision of informed consent.

        Exclusion Criteria:

          -  History of peptic ulcer disease with bleeding or obstruction.

          -  Clinically significant liver or kidney disease.

          -  History of hypersensitivity to aspirin, ibuprofen, celecoxib, naproxen, or other
             NSAIDs.

          -  Use of anti-coagulant medication.

          -  Cognitive impairment or dementia.

          -  Current alcohol abuse or dependence
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 70 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Hemochromatosis--Genetic Prevalence and Penetrance

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Mesh Fixation and Closure of Peritoneum Following Laparoscopic Hernia Repair Using N-butyl Cyanoacrylate

Eligibility criteria:
Inclusion Criteria:

          -  Inguinal hernia,

          -  femoral hernia

        Exclusion Criteria:

          -  pregnancy,

          -  not able to understand patient information
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Minimally Invasive Benign Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  indication for hysterectomy for benign disease or prophylactic surgery due to
             hereditary cancer

          -  size of uterus and vagina allows for retrieval by the vaginal route

          -  maximum uterine size equivalent to 16 weeks of pregnancy

          -  informed consent

        Exclusion Criteria:

          -  malignant disease

          -  known extensive intra-abdominal adhesions

          -  anaesthesiological contraindications to laparoscopic surgery

          -  women with pacemaker or other implants where electrosurgery is to be avoided

          -  immunoincompetent women

          -  simultaneous need for prolapse surgery

          -  women with known defects of the hemostasis

          -  allergies towards metronidazole and doxycycline

          -  inability to understand patient information
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Vitamin E and Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  infertile men with previously abnormal semen analyses.

          -  Control group: fertile adult males

        Exclusion Criteria:

          -  Proxceed use within 3 months of the start of study.

          -  Vitamin E supplements with > 45 IU daily
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Study of FYU-981 in Hyperuricemia With or Without Gout

Eligibility criteria:
Inclusion Criteria:

          -  Hyperuricemic or gout patients

          -  Serum urate level:

        >= 7.0mg/dL in patients with history of gout, or >= 8.0mg/dL in patients with hypertension,
        diabetes or metabolic syndrome, or >= 9.0mg/dL

        Exclusion Criteria:

          -  Gouty arthritis within two weeks before start of study treatment

          -  Secondary hyperuricemia

          -  HbA1c: >= 8.4%

          -  Uric acid-overproduction type in the classification of hyperuricemia

          -  History of, clinically significant cardiac, hematologic and hepatic disease

          -  Kidney calculi or clinically significant urinary calculi

          -  eGFR: < 30mL/min/1.73m^2

          -  Systolic blood pressure: >= 180 mmHg

          -  Diastolic blood pressure: >= 110 mmHg
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction