Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: RosaC-RF : Bipolar Radiofrequency vs Doxycycline in Rosacea

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must be between 18-70 years old

          -  Subjects with papulopustular rosacea graded moderate to severe (2 or 3) according to
             the physician global Assessment, and with lesions on the cheeks.

          -  Prior stop of any topical treatment antibiotic, retinoid, corticoid or other topical
             treatment for rosacea at least 1 month before the start of the study

          -  Prior stop of any systemic treatment (antibiotic) two month before the start of the
             study and for isotretinoin at least 6 months

          -  Last laser treatment, by lamp, laser or LED, at least 3 months before the start of the
             study

          -  Subjects must be abble to lie for more than 30 minutes

          -  Patient able to understand and sign the informed consent form

          -  Affiliation to a social security scheme

        Exclusion Criteria:

          -  Women of child bearing/reproductive potential

          -  Other skin disease or abnormality of the face which could interfere with the
             evaluation of the different criteria evaluated or with the realization of the RF

          -  Contraindications to radiofrequency: presence of a defibrillator or pacemaker, dental
             on the cheeks, dental equipment or metallic orthopedic next to the treated area, skin
             cancer on the face, progressive systemic disease, uncontrolled hypertension

          -  Immunosuppression by HIV (determined by examination) or treatment with
             immunosuppressive

          -  Tattoos or permanent makeup on the face

          -  Excessively tanned skin to sunlight, ultraviolet or with tanning creams during the
             last 2 weeks

          -  Subject carrying cochlear implants or open wound or in the process of healing

          -  Minor patient or under tutorship

          -  Cyanoacrylate or doxycycline allergy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment