Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Study of 3 Doses of ARD-0403 in Testosterone Deficient Men

Eligibility criteria:
Inclusion Criteria:

          -  Testosterone deficiency

          -  Normal BMI

        Exclusion Criteria:

          -  Previous treatment with testosterone replacement therapy within 4 weeks

          -  Moderate-severe benign prostatic hypertrophy, or prostatic cancer

          -  Haematocrit >50%
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia

Eligibility criteria:
Inclusion Criteria:

          1. clinical diagnosis of primary adrenal insufficiency

          2. Written informed consent

        Exclusion Criteria:.

          1. Diabetes mellitus

          2. Severe cardiovascular disease

          3. Active malignant disease

          4. Pregnancy or breast feeding

          5. treatment with interfering drugs

          6. Intake of grapefruit juice
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)

Eligibility criteria:
Inclusion Criteria:

          -  Minimum of 12 months history of heartburn as the predominant symptom with at least 2
             symptomatic episodes

          -  Negative endoscopy (no erosive lesions according to the Modified Savary-Miller scale)
             within 7 days prior to acute treatment

          -  at least 3 days with moderate to very severe heartburn within one week prior to acute
             treatment

        Exclusion Criteria:

          -  No known gastro-duodenal ulcer

          -  no infections, inflammations, or obstruction of the small or large intestine

          -  no history of gastrointestinal cancer, or prior surgery of the stomach or intestine

          -  no stomach or abdominal pain or discomfort as the predominant symptom or that requires
             treatment

          -  no history of erosive reflux causing inflammation of the esophagus

          -  no stricture of the esophagus, stomach, or any condition that causes difficulty in
             swallowing

          -  no history of non-erosive reflux disease (NERD) that is or was refractory to an
             adequate treatment course (1 month) with proton pump inhibitors

          -  no females who are pregnant or those lacking adequate contraception
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cell in Patients With Amyotrophic Sclerosis Lateral

Eligibility criteria:
Inclusion Criteria:

          1. Women and males over 18-year-old.

          2. Good understanding of the protocol and aptitude to grant the informed assent.

          3. Diagnosis of sporadic ALS, with diagnosis of certainty, that is to say, definite or
             probable, in agreement with the criteria of "El Escorial", of the World Federation of
             Neurology.

          4. Forced vital capacity of at least 50 % of the one that would correspond to them for
             sex, height and age.

          5. More than 6 and less than 36 months of evolution of the disease (from the beginning of
             the symptoms).

          6. Possibility of obtaining, at least, 50gr of adipose tissue.

          7. Treatment with riluzole, for at least, a month before the inclusion.

        Exclusion Criteria:

          1. Any concomitant disease that under investigator's criteria could concern the measures
             of the clinical variables of the trial (hepatic, renal or cardiac insufficiency,
             diabetes mellitus, etc).

          2. Previous therapy with stem cells.

          3. Participation in another clinical trial during 3 months previous to the entry in this
             trial.

          4. Any disease lymphoproliferative

          5. Tracheostomy and /or gastrostomy.

          6. Haemophilia, diathesis hemorrhagic or anticoagulative current therapy.

          7. Hypersensitivity known to the bovine foetal whey or the gentamicin.

          8. Medical precedents of infection of the HIV or any serious condition of
             immunocompromised.

          9. Positive HBV or HCV serology

         10. Levels of creatinine in whey > 3.0 in subjects not submitted to haemodialysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Parent diagnosed with Alzheimer's disease

          -  Age 40-72

        Exclusion Criteria:

          -  Active liver disease

          -  History of adverse reaction to statins

          -  Contraindication to lumbar puncture

          -  Elevated creatine kinase and creatinine lab values

          -  Use of medications known to interact with statins

          -  History of dementia or mild cognitive impairment

          -  Currently pregnant or planning to become pregnant

          -  Use of large quantities of grapefruit juice (more than 1 quart per day)

          -  Contraindications to MRI (for MRI sub-study)

          -  Currently on cholesterol-lowering medication or use in past 4 months

          -  History of heart attack, heart problems, stroke and/or diabetes

          -  Drinking more than a quart of grapefruit juice per day

          -  Metal implants, or metal debris in body (MRI)

          -  List of medications that interact with simvastatin
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 72 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Impact of Sleep Disruption on the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Healthy

          -  Regular menstrual cycles

        Exclusion Criteria:

          -  No medications affecting the menstrual cycle or sleep
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Investigation of the Proportion of Human Epidermal Growth Factor Receptor 2 Protein Overexpression of Gastric Adenocarcinoma and Prognostic Effect of HER2, and Analysis of Practice Pattern of Herceptin Use in Stage IV Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Histologically confirmed gastric adenocarcinoma

          2. Patients were diagnosed during 2006-2013

          3. HER2 expression status was evaluated in primary gastric cancer or metastatic lesion.

        Exclusion Criteria:

          -  Patients with second primary cancer within 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Multistability: Perception is Inspired by Noise

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Medical examination carried out before the participation in the research

          -  Age between 18 and 55 years

          -  Minimum level of studies

          -  Obligation to join the social security system

          -  normal or corrected vision normal

        Exclusion Criteria:

          -  Subject included in another clinical and / or therapeutic experimentation in progress

          -  Major vision disorder

          -  Past or current neurological or neuropsychiatric pathologies

          -  History of cranial trauma with loss of consciousness.

          -  Medication treatments likely to modulate brain activity: benzodiazepine,
             antidepressants, neuroleptics, lithium, etc.

          -  Diabetes, cardiac pathology, immunodeficiency.

          -  Medication treatments likely to modulate the activity of the cardiovascular system.

          -  History of abuse or recent ingestion of alcohol, hard drugs or doping products.

          -  Consumption of more than 15 cigarettes per day

          -  Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)

          -  Major subject subject to a legal protection measure or unable to express their consent
             (L1121-8 CSP)

          -  Pregnant, parturient and nursing mothers (L1121-5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Soft Drinks and Osteoporosis in WHI Participants

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women

          -  More than one day of follow up

          -  Dietary information on soft drinks

        Exclusion Criteria:

        Previous hip fracture
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Clinical Study of Cochlear Implants in Adults With Asymmetrical Hearing Loss

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older at time of surgery

          -  The poorer ear (implant ear) will have a severe-to-profound hearing loss and meet
             current cochlear implant candidacy criteria.

          -  The better ear (contralateral ear) will have hearing levels less than current cochlear
             implant candidacy criteria and stable/non-fluctuating hearing levels for at least the
             previous year

          -  Normal/patent cochlear anatomy

          -  Fluent in English

          -  Desire to have more functional binaural hearing and willingness to comply with all of
             the study requirements

        Exclusion Criteria:

          -  Medical or psychological conditions that contraindicate undergoing surgery

          -  Additional handicaps that would prevent or restrict participation in the audiological
             evaluations

          -  Ossification or any other cochlear anomaly that might prevent complete insertion of
             the electrode array

          -  Hearing loss of neural or central origin, including auditory neuropathy

          -  Chronic and severe tinnitus in the ear to be implanted

          -  Unwillingness or inability to comply with all investigational requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment