Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: The Accuracy of Late Night Urinary Free Cortisol/Creatinine and Hair Cortisol in Cushing's Syndrome Diagnosis

Eligibility criteria:
Inclusion Criteria:

        1. Patients referred to our outpatient endocrinology clinic for medical evaluation due to
        CS suspicion or adrenal incidentaloma evaluation

        Exclusion Criteria:

          1. Serum creatinine level concentration above 1.5 mg/deciliter

          2. Systemic, dermal or nasal steroid use

          3. Chronic inflammatory disease

          4. Any infectious disease requiring hospitalization or more that 2 weeks of antibiotic
             treatment in the previous 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Spironolactone Versus Prednisolone in DMD

Eligibility criteria:
Inclusion Criteria:

          -  Duchenne muscular dystrophy (DMD) patients ≥4 to ≤7 years of age

          -  Clinical features of DMD that include proximal predominant weakness and/or gait
             disturbance

          -  Presence of a truncating mutation of the DMD gene OR a muscle biopsy that demonstrates
             <5% dystrophin in the patient or an affected relative

          -  Normal left ventricular ejection fraction by screening echocardiogram

          -  Ability to cooperate for testing

          -  No prior glucocorticoid treatment

          -  No concomitant experimental therapies

        Exclusion Criteria:

          -  Subject amenable to or currently being treated with eteplirsen

          -  Hyperkalemia at screening

          -  History of or ongoing renal failure (elevated creatinine, oliguria, anuria)

          -  Hypersensitivity to spironolactone (rash, respiratory distress, arrhythmia, numbness
             or tingling of extremities)

          -  Current treatment with an ACEi

          -  Severe peptic ulcer disease or recent gastrointestinal perforations
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Fermented Soy and Heartburn Symptom Relief

Eligibility criteria:
Inclusion Criteria:

          -  Able to provide written informed consent in English.

          -  Willing to have height and weight measured and provide demographic information (e.g.
             age, race, sex)

          -  Experience heartburn symptoms at least 2 days a week during the past 3 months.

          -  Use OTC product(s), supplements, or dietary manipulation to relieve heartburn symptoms
             in the last 3 months.

          -  Willing to take the study soy supplement before resorting to OTC product(s) to control
             heartburn symptoms.

          -  Willing to complete questionnaires, records, and diaries associated with the study and
             to complete all clinical visits.

          -  Willing to provide information about dietary intake; 3-day online 24-hr recalls during
             baseline, intervention, and washout.

          -  Willing and able to provide a valid social security for study payment purposes.

        Exclusion Criteria:

          -  Do not meet the above criteria.

          -  Soy allergy

          -  Severe heartburn problem (cannot be ignored and often limits your concentration on
             daily activities) during the last week

          -  Diagnosed or currently being treated for any gastrointestinal diseases including GERD,
             gastric ulcers, Crohn's, celiac, ulcerative colitis, etc.

          -  Self-disclosed as pregnant or breast-feeding or planning on becoming pregnant during
             the study duration.

          -  Currently participating in another clinical study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Autoimmunity in Inner Ear Disease

Eligibility criteria:
Inclusion Criteria:

          -  Have sensorineural (nerve/inner ear) hearing loss of at least 30 dB in each ear, which
             has rapidly progressed.

          -  Are in good general health.

          -  Are sterile or use contraception (if a woman of child-bearing age).

          -  Are able to speak and understand English or Spanish.

        Exclusion Criteria:

          -  Have had any previous reaction to prednisone, or history of psychiatric reaction to
             corticosteroids.

          -  Have used corticosteroids for more than 30 days within the past 90 days. Patients who
             have been off corticosteroids for at least 30 days may be eligible.

          -  Have any significant heart, lung, digestive, blood, or neurologic disorders.

          -  Have tuberculosis (TB), brittle or unstable insulin-dependent diabetes mellitus,
             active malignancy or prior chemotherapy, pancreatitis, active peptic ulcer disease,
             kidney failure, history of shingles, or known (other) autoimmune disease.

          -  Have had a positive test for HIV, hepatitis C or B.

          -  Have any type of middle ear disorder.

          -  Are breast-feeding or pregnant.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Photodynamic Therapy for the Treatment of COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Hospitalized patients with Positive COVID 19 test suffering from Fever, cough,
             shortness of breath, chills, muscle pain, the new loss of taste or smell, vomiting or
             diarrhea, and/or sore throat

        Exclusion Criteria:

          -  Patients in critical cases who admitted to the ICU, bacterial pneumonia, and
             respiratory distress grade III, IV, and patients on a mechanical ventilator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Weight-based Dosing in Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Adult males age 18 or older.

          2. Hemophilia A (FVIII activity 40% or less).

          3. Overweight or obesity defined as a BMI of 25.0-29.9 and ≥ 30 mg/m2, respectively.

        Exclusion Criteria:

          1. Prior history of, or currently detectable, FVIII inhibitor defined as greater than or
             equal to 0.6 Bethesda Units (BU); however, a subject with a past low-level
             non-responding inhibitor defined as less than 5 BU, with no increase in titer
             following FVIII exposure, and not detectable within 12 months of the study, despite
             FVIII exposure during that period, will be allowed to enroll on study.

          2. Allergy to FVIII products.

          3. Current rFVIII requirements do not include at least a 72-hour period without rFVIII
             administration.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Ultrasound Evaluation of Bone Age in Healthy Children

Eligibility criteria:
Inclusion Criteria:

        Children aged 4-17 years old Children with normal (3%-97%) height values for their age
        Children with normal (3%-97%) weight values for their age Children with normal (5%-85%) BMI
        value for their age Children of Caucasian ethnical origin A signed Informed Consent Form
        that was obtained from at least one parent or legal guardian, prior to ultrasound study.

        An assent from the child to perform the SonicBone's BA device measurement

        Exclusion Criteria:

        Children taking any medication that might change bone metabolism or mineralization within
        the last year (glucocorticosteroids, sex steroids, oral contraceptives, anticonvulsants,
        calcium and vitamin D in superphysiological doses) Children with suspected bone diseases,
        metabolic diseases, chronic diseases or multiple fractures.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Tamoxifen Treatment in Patients With Motor Neuron Disease

Eligibility criteria:
Inclusion Criteria:

          1. Clinical diagnosed and confirmed ALS patients, with regular follow up and oral form
             riluzole at National Taiwan University or Shuang- Ho Hospital for more than 6 months.

          2. Age ≧20 years old

        Exclusion Criteria:

          1. Patients who had already ventilator dependent, not regular followed up for more than 6
             months or against medical advice, refuse to follow up at neurology department will be
             excluded in this study.

          2. Patients with now or previous usage of Tamoxifen

          3. Patients with any contraindications of Tamoxifen usage

          4. Patients with other internal medicine illiness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Longitudinal Follow up of Patients With Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Patients presented with pleural effusion

          -  Patients who undergo thoracentesis and fluid analysis for diagnosis and management

        Exclusion Criteria:

          -  Patients who refuse to be enrolled
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Participants must be at least 12 years old.

          -  Participants must have a clinically diagnosed craniofacial condition.

          -  Participants must be able to speak and write in English. However, if individuals have
             trouble writing (i.e. dyslexia or dysgraphia), they can tape record their personal
             reflections, which will be transcribed verbatim for analysis.

        EXCLUSION CRITERIA:

          -  If the individual is younger than 12 years of age.

          -  If the individual does not speak English.

          -  If the individual has been photographed by Rick Guidotti or another professional
             photographer in the past.

          -  If the individual has been video-interviewed by Diane McLean.

          -  If the individual has cognitive impairments that would preclude successfully
             completing the various steps of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Entailment