Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease.

Eligibility criteria:
Inclusion Criteria:

          -  Patient has an established diagnosis of GERD according to the investigator, or an
             occurrence of at least 1 typical GERD symptom (i.e., heartburn or regurgitation) at
             least once a week during the last 3 months.

          -  Patient has presented at least 1 typical GERD symptom (i.e., heartburn or
             regurgitation) in the week preceding the study visit.

        Exclusion Criteria:

          -  Exclusively atypical digestive or non-digestive symptoms (e.g., epigastralgia,
             respiratory disturbances, thoracic manifestations, etc.)

          -  Current or recent (less than 1 year) history of gastric or duodenal ulcer

          -  History of surgery of the upper digestive tract

          -  Tumor of the superior digestive tract or ENT system;

          -  Pregnant or breastfeeding woman
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Magnetic Anchoring Guided Endoscopic Submucosal Dissection for Early Gastric Caner

Eligibility criteria:
Inclusion Criteria:

          -  Patients are diagnosed as of gastric cancer by a preliminary endoscopy or biopsy
             sampling

        Exclusion Criteria:

          -  Patients with a cardiac pacemaker or severe cardiac and/or pulmonary diseases

          -  Patients without informed consent

          -  Patients with other malignant tumors
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Effect of Oral Glutamine on Muscle Mass and Function in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Duchenne muscular dystrophy

          -  Able to walk >170 m

          -  Absence of hepatic insufficiency

          -  Absence of renal insufficiency

        Exclusion Criteria:

          -  Dependent upon wheelchair

          -  Body weight >60kg

          -  Liver failure

          -  Kidney failure

          -  Surgery scheduled during the year following the first visit
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Detection of Helicobacter Pylori Infection by High Resolution Endoscopy

Eligibility criteria:
Inclusion Criteria:

          -  Patients who underwent upper endoscopy

        Exclusion Criteria:

          -  Age < 20 or > 70

          -  Severe systemic disease or advanced chronic liver disease

          -  Medication history of NSAID, PPI, H2 blockers or antibiotics

          -  History of H. pylori eradication therapy

          -  History of gastric surgery

          -  Recent history of upper GI bleeding

          -  Gastric or duodenal ulcer (including old scar change) during endoscopy

          -  Anemia (Hemoglobin level < 10mg/dL)

          -  Pangastritis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of Clinical Characteristics and Outcome of COVID19 Pneumonia in Assiut University Hospital

Eligibility criteria:
Inclusion Criteria:

          -  Patients with COVID 19 PCR positive

        Exclusion Criteria:

          -  Patients less than 18 years of age .
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A RCT on the Effect of Endometrial Injury on Improving Ongoing Pregnancy Rate in Subfertile Women Undergoing FET Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Undergoing FET treatment cycles

          -  Normal uterine cavity as shown on transvaginal scanning or saline sonogram done at
             baseline

          -  endometrial thickness >=8mm during the stimulated IVF cycle and FET cycle

        Exclusion Criteria:

          -  Pregnancy in previous IVF or FET cycles

          -  Presence of hydrosalpinx not surgically corrected prior to FET

          -  Presence of endometrial polyp or fibroid distorting uterine cavity

          -  IVF cycles carried out for preimplantation genetic diagnosis

          -  Arrange for blastocyst transfer

          -  Use of donor oocytes
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Phase 2 Study of URC102 to Assess the Efficacy and Safety in Gout Patients

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with gout

        Exclusion Criteria:

          -  Participated in other clinical study within 12 weeks prior to enrollment, and received
             an investigational product (including placebo)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Registry for Integrative Medicine Interventions Effectiveness

Eligibility criteria:
Inclusion Criteria:

          -  Be seen as a clinical patient in one of the participating Integrative Medicine (IM)
             clinics and willing to participate in the Registry

          -  Be 18 years of age or older

          -  Have access to a computer with internet connection and a valid email address

          -  Be willing to be contacted in the future by study investigators

        Exclusion Criteria:

          -  Not being seen by a provider for clinical purposes, but only involved in an education
             program or one-time activity
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Methorexate and Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  primary knee osteoarthritis

          -  synovitis

          -  pain

        Exclusion Criteria:

          -  other inflammatory conditions

          -  hepatic insufficiency

          -  renal insufficiency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: ADVATE Post Authorization Safety Surveillance

Eligibility criteria:
Inclusion Criteria:

          -  Subject has moderate or severe hemophilia A (baseline FVIII less than or equal to 5%)

          -  Subject currently has no measurable FVIII inhibitor titer greater than or equal to 1
             BU (Bethesda or Nijmegen method)

          -  Subject has been prescribed ADVATE by their treating physician

          -  Subject may be of any age

          -  Subject or parent/legally authorized representative has provided written informed
             consent

        Exclusion Criteria:

          -  None
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic unilateral knee tibiofemoral OA

          -  Radiographic evidence of knee OA of Kellgren-Lawrence Grade II or III in one or both
             knees on a recent 3 months time X-Ray

          -  Knee pain within the last 24 hours before assessment more than 40mm on VAS

          -  Pain on most days in the last month

        Exclusion Criteria:

          -  Knee pain equal or more than 80mm on a 100mm VAS.

          -  Pain in the contra lateral knee; more than 30mm on a 100 VAS.

          -  Concomitant inflammatory joint disease (e.g. gout, rheumatoid arthritis, history of
             Reiter's syndrome, psoriatic arthritis and ankylosing spondylitis.

          -  Any condition that may interfere with the measure of pain in the targeted knee

          -  Concomitant meaningful synovial fluid effusion

          -  Post trauma OA

          -  Gross ligamentous instability of the knee
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Genetic Basis of Rosacea Study (Control)

Eligibility criteria:
Inclusion criteria include:

          1. Fitzpatrick skin type II or III

          2. Age greater than or equal to 18 years

          3. Individuals without a history of rosacea

        Exclusion criteria include:

          1. Women who are pregnant or lactating

          2. Use of topical prescription medications or procedures to the face within one month of
             enrollment

          3. Skin conditions that might interfere with interpretation of procedure results (at the
             discretion of the investigator)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment