Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Platform Exercise Training

Eligibility criteria:
Inclusion Criteria:

          -  age 45-60

          -  female

          -  history of knee injury or surgery (except replacement surgery) or body mass index
             (BMI) greater than or equal to 25.

        Exclusion Criteria:

          -  diagnosis of knee osteoarthritis

          -  inflammatory arthritis such as rheumatoid or psoriatic arthritis

          -  knee replacement

          -  metallic implant or stent placement surgery or any implanted devices

          -  surgery or lower limb injury in the last 6 months that affects walking ability

          -  lower limb amputation (other than single ray)

          -  unable to walk without an assistive device

          -  wounds that contraindicate weight-bearing exercise

          -  acute infection or inflammation that contraindicates exercise

          -  acute disk related problems (new lower back pain in the last 3 months or severe enough
             to affect walking)

          -  osteonecrosis

          -  currently pregnant or planning to become pregnant

          -  kidney, bladder or gallstones that have not been passed

          -  retinal detachment

          -  ever experienced deep vein thrombosis

          -  type 1 diabetes mellitus (insulin dependent)

          -  history of myocardial infarction or stroke in the last year

          -  medical conditions that affect walking ability or ability to take part in the study or
             exercise such as; Alzheimer's disease, multiple sclerosis, Parkinson's disease, severe
             cardiovascular disease, congestive heart failure, severe emphysema, severe asthma,
             severe dysrhythmias or pacemaker

          -  Any type of implanted pump (e.g. Morphine, baclofen) or catheter (e.g. In kidney,
             brain or spine)

          -  neuropathy (by Semmes-Weinstein Monofilament)

          -  uncontrolled epilepsy

          -  active cancer (< 5 years since remission) or other illness expected to be terminal
             within 1 year

          -  concurrent participation in another research study

          -  Inability to follow protocol (e.g. lack of ability to attend visits or understand
             instructions)

          -  frequent knee pain on most of the last 30 days
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction