Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Safety, Efficacy and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor IX With Albumin (rIX-FP) in Children With Hemophilia B

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects, younger than 12 years old.

          -  Severe hemophilia B (Factor IX [FIX] activity of ≤ 2%).

          -  Body weight ≥ 10 kg.

          -  Subjects who have received FIX products (plasma-derived and/or recombinant FIX) for >
             150 exposure days (EDs) (6 to < 12 years), and > 50 EDs (< 6 years).

          -  No history of FIX inhibitor formation, no detectable inhibitors at Screening and no
             family history of inhibitors against FIX.

          -  Written informed consent for study participation.

        Exclusion Criteria:

          -  Known hypersensitivity to any FIX product or hamster protein.

          -  Known congenital or acquired coagulation disorder other than congenital FIX
             deficiency.

          -  Kidney or liver disease.

          -  Recent life-threatening bleeding episode.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 11 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.

Eligibility criteria:
Inclusion Criteria:

        Arm 1 (newly diagnosed ALS patients)

          -  Have a clinical diagnosis of probable ALS according to the revised El Escorial
             criteria.

          -  MR of the brain and cervical spine cannot explain symptoms.

          -  Diagnosed with likely ALS within 6 months from enrolment and treated with Riluzole
             50mg x 2

          -  Symptom onset no longer than 2 year prior to inclusion.

          -  ALS-FRC-R of 36 or more (not any item below 2).

          -  Age equal to or greater than 35 years at time of enrollment

        Arm 2 (earlier diagnosed ALS patients)

          -  Have a clinical diagnosis of probable ALS according to the revised El Escorial
             criteria.

          -  MR of the brain and cervical spine cannot explain symptoms.

          -  Treated with Riluzole 50mg x 2.

        Exclusion Criteria:

          -  Dementia, FTD or other neurodegenerative disorder at baseline visit

          -  Any psychiatric disorder that would interfere with compliance in the study.

          -  Use of high dose vitamin B3 supplementation within 30 days of enrollment

          -  Metabolic, neoplastic, or other physically or mentally debilitating disorder at
             baseline visit.

          -  Genetically confirmed mitochondrial disease

          -  Patients who become tracheostomized as part of the treatment of ALS

          -  Patients with short expected survival at the discretion of the investigator. Such
             cases cannot be expected to follow protocol procedures.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: New Use of the ViKY Device for Uterus Positioning

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-80

          -  Candidate for conventional laparoscopic-assisted hysterectomies procedures

          -  patient has a cervix and a uterus

        Exclusion criteria

          -  Difficulty understanding the English language

          -  Anatomy that precludes the use of a uterine manipulator

          -  Current inclusion in another research study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Based on the Ultrasound Evaluating the Effect of Xiaozhong Fang Particles for Knee Osteoarthritic With Synovial Fluid

Eligibility criteria:
Inclusion Criteria:

          -  1) the American Society of Rheumatology established the diagnostic criteria for knee
             OA in 2001;

          -  2) Kellgren/Lawrence score of knee joint grade as I,II and early III.

          -  3) According to "Principles of clinical guidance for new drugs of traditional Chinese
             Medicine ",diagnosed as "Xi Bi Disease".

          -  4) Patients with informed consent.

          -  5)Blood and urine routine tests, liver and kidney functions, electrocardiogram were
             normal before recruitment.

          -  6) Patients were not treated with NSAIDS drugs or hormone drugs, and no patients were
             treated with drugs related to this disease at least 2 weeks.

        Exclusion Criteria:

          -  1)Patients suffer from other rheumatic and metabolic diseases such as gout, rheumatoid
             arthritis, diabetes and so on.

          -  2) Patients with knee joint inflammatory infection, such as suppurative and
             nonspecific.

          -  3)Patients accompanied by traumatic synovitis, Villonodular pigmented synovitis,
             synovial membrane of the knee is the main lesion.

          -  4) Patients with informed consent.

          -  5)The color of joint fluid of patients' knees is pink or other color or cloudy; the
             white blood cell counts > 1000 /mm3 or with crystal in the joint fluid.

          -  6)Patients blood RF > 30IU/ml, ESR > 20mm/h, CRP > 10mg/L.

          -  7)Patients combined with severe cardiovascular, cerebrovascular, liver, kidney and
             other primary diseases and mental diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Adding Gonadotropins Releasing Hormone Agonist to Progesterone for Luteal Phase Support in Assisted Reproductive Technique (Antagonist Cycles).

Eligibility criteria:
Inclusion Criteria:

          1. Age between 20 to 40 years.

          2. Baseline FSH > 10 IU/L.

          3. Fresh stimulated cycles

          4. Antagonist cycles

        Exclusion Criteria:

          1. Uterine fibroid if encroaching uterine cavity.

          2. Mullerian anomalies.

          3. Ovarian endometrioma.

          4. Adnexal hydrosalpinx "except after disconnection".

          5. Ovarian hyper stimulation syndrome (OHSS) an exaggerated systemic response to ovarian
             stimulation characterized by a wide spectrum of clinical and laboratory
             manifestations. It is classified as mild, moderate, or severe according to the degree
             of abdominal distention, ovarian enlargement, and respiratory, hemodynamic and
             metabolic complications.

          6. Poor responders according to bologna criteria.

          7. Women refused to participate in an RCT.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-90 years

          -  Dyspnea or/and peripheral edema

          -  Informed consent

        Exclusion Criteria:

          -  Renal insufficiency with creatinine > 2.8mg/dl

          -  Anemia (hemoglobin < 8.0mg/dl)

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Effect of CPAP on Breath Hold and Chest Movement in Normal Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Normal volunteers without a cancer diagnosis.

          -  No contraindications to the use of CPAP

               -  Facial injury or deformity preventing wearing facial mask

               -  Recurrent vomiting

               -  Chronic cough with phlegm

               -  Previous pneumothorax

               -  Facial lacerations or fractures

               -  Recent tracheal or esophageal anastomosis

               -  Recent GI surgery (last 90 days).

          -  18-90 years of age

          -  Ability to sign informed consent

          -  Hebrew or English speakers

        Exclusion Criteria:

          -  Contraindications to CPAP

               -  Facial injury or deformity preventing wearing facial mask

               -  Recurrent vomiting

               -  Chronic cough with phlegm

               -  Previous pneumothorax

               -  Facial lacerations or fractures

               -  Recent tracheal or esophageal anastomosis

               -  Recent GI surgery (last 90 days).

          -  Under age 18 or above age 90 years

          -  Inability to sign informed consent

          -  Members of special populations (mental illness, pregnant women, prisoners, not legally
             competent).

          -  History of severe active restrictive or obstructive lung disease (as defined as at
             least one hospitalization over previous two years)

          -  Any medical condition requiring an inpatient hospitalization for more than 72 hours
             over the previous 2 years, aside from elective surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Aspirin Use and Postoperative Bleeding From Dental Extractions in a Healthy Population

Eligibility criteria:
Inclusion Criteria:

          -  Healthy

          -  Require a simple tooth extraction

        Exclusion Criteria:

          -  Use of previous aspirin or NSAID
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Preventing Inhibitor Recurrence Indefinitely

Eligibility criteria:
Inclusion Criteria:

          1. Age ≤12 years at the time of signing the informed consent

          2. Male patients with severe (<1%) or moderate (<2%) hemophilia A

          3. History of a high titer (>5 BU) inhibitor

          4. Within 1 year of successful ITI, according to ISTH definitions (inhibitor titer <0.6
             BU, recovery more than 60% of expected, and half-life of >6 hours). Successful ITI has
             been achieved with any FVIII concentrate.

          5. Currently on emicizumab or willing to alter their prophylaxis treatment to emicizumab
             per study protocol.

        Exclusion Criteria:

          1. Age >12 years at the time of signing the informed consent

          2. Partial tolerance (not meeting criteria for complete tolerance per ISTH)

          3. History of anti-drug antibodies to emicizumab

          4. Unwilling to receive exposure to intravenous FVIII concentrates.

          5. History per the investigator's discretion of non-compliance to prior therapy.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Electroacupuncture Improves Pain and Wrist Functionality

Eligibility criteria:
Inclusion Criteria:

          1. Orthopedic specialist diagnoses tearing of the triangular fibrocartilage complex and
             undergoes arthroscopic surgery

          2. Age between 19 and 60 years old

        Exclusion Criteria:

          1. serious heart rhythm

          2. epilepsy

          3. Severe pulmonary heart disease

          4. History of mental illness

          5. received acupuncture treatment 1 month ago
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction