Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Outpatient Treatment With CoVid-19 With Prexablu

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 18 years of age

          -  Of both sexes

          -  Confirmed case of Covid-19 (by RT-PCR) and CT less than 32 in the E

          -  That they go to the ER service due to COVID symptoms, and that they voluntarily agree
             to participate in the study by written the informed consent

          -  With at least 1 of the following symptoms: fever, headache, nausea, dyspnea, myalgia,
             vomiting, or diarrhea

          -  With chest X-ray without pneumonia criteria

          -  With SO2> 90

          -  No history of allergic reaction to methylene blue

          -  No history of treatment with medication with methylene blue negative interaction

        Exclusion Criteria:

          -  Pregnancy and breastfeeding

          -  Preadmission anticoagulation

          -  Severe renal insufficiency (glomerular filtration rate <30 mL/min/1.73m2)

          -  Active chronic hepatitis

          -  Patients with history of allergic reaction or significant sensitivity to methylene
             blue

          -  Treatment with immunosuppressive agents

          -  Diagnosis of cancer at any stage and of any type.

          -  Pregnancy and breastfeeding

          -  Patients who plan to become pregnant during the study period or within 6 months after
             the end of the study period.

          -  Participation in another clinical trial with an experimental drug in the last 30 days.

          -  Other pathologies that, in the medical opinion, contraindicate participation in the
             study.

          -  Uncompensated comorbidities
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Become of Patients Infected or Suspected of Being Infected by Covid-19 and Supported by the GHPSJ and the Establishments of the Paris Plaisance Hospital City

Eligibility criteria:
Inclusion Criteria:

        - Patient (of all ages) with symptoms compatible with infection by Covid-19 treated at the
        GHPSJ or in one of the establishments in the Paris Plaisance hospital city.

        Exclusion Criteria:

          -  Asymptomatic patient

          -  Patient objecting to the use of their data
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: CF Bronchodilation

Eligibility criteria:
Inclusion Criteria:

          -  Male or female with confirmed diagnosis of CF based on consensus criteria

          -  Aged 19 years or older

          -  Stable clinical status

          -  Pre-bronchodilator FEV1.0 between 30% and 90% predicted

          -  Body mass index between 16 and 30 kg/m2

          -  Currently non-smoking or a past smoking history of less than 20 pack-years

        Exclusion Criteria:

          -  A disease other than CF that could importantly contribute to dyspnea or exercise
             limitation

          -  Chronic airway infection with Mycobacterium abscessus, Burkholderia cepacia complex,
             or other organisms with infection control implications according to the treating
             physicians Contraindications to clinical exercise testing

          -  Use of supplemental oxygen or desaturation less than 80% with exercise

          -  History of solid organ transplantation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Phase III Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Written consent/assent by patient and/or legal guardian as per regional and/or
             Institutional Review Board (IRB)/Independent Ethics Committee (IEC) requirements

          -  Diagnosis of DMD based on a clinical phenotype with increased serum creatine kinase
             (CK) and documentation of mutation(s) in the dystrophin gene known to be associated
             with a DMD phenotype

          -  Able to perform stand from supine without assistance in ≤ 10 seconds

          -  Able to perform the 10MWT and 4-stair climb

          -  Followed by a doctor or medical professional who coordinates Duchenne care on a
             regular basis and willingness to disclose patient's study participation with medical
             professionals

        Exclusion Criteria:

          -  Use of corticosteroids within 24 weeks prior to Day 1; use of inhaled, intranasal, and
             topical corticosteroids is permitted

          -  Use of another investigational drug, idebenone, or dystrophin-focused therapy within 4
             weeks. Exception: Patients who have received at least 24 weeks of a stable dose of
             eteplirsen prior to Day 1, and expected to continue treatment, will be eligible

          -  Use of the following within 4 weeks prior to Day 1: immunosuppressive therapy,
             warfarin, phenytoin, S mephenytoin, cyclosporine, dihydroergotamine, ergotamine,
             fentanyl, alfentanil, pimozide, quinidine, sirolimus, tacrolimus, or paclitaxel

          -  Use of human growth hormone within 3 months prior to Day 1

          -  Other prior or ongoing significant medical conditions
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Gastric Cancer Precursor Lesions (GCPL) Study

Eligibility criteria:
-  INCLUSION CRITERIA:

        Two groups of symptomatic patients aged 40 to 70 years old, who are long term residents of
        a high gastric cancer risk area:

          -  Approximately 1300 patients who need upper endoscopy (examination of the lining of the
             stomach with a flexible tube).

          -  Approximately 100 patients recently diagnosed with stomach cancer who need surgery as
             treatment for the disease.

        EXCLUSION CRITERIA:

          -  Pregnant women

          -  Children
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient's own account: I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Clinical trial: Evaluation of Two Different Thickening Products in Patients With Dysphagia

Eligibility criteria:
Inclusion Criteria:

          -  History of dysphagia necessitating a dynamic fluoroscopic swallow study

          -  Age > 18 years

          -  Ability to complete a comprehensive dynamic fluoroscopic swallow study

          -  Ability to provide informed consent for study participation

        Exclusion Criteria:

          -  Age < 18 years

          -  Pregnant women

          -  Prisoner or other institutionalized individual

          -  Cognitive disability precluding the ability to provide informed consent or complete a
             comprehensive swallow study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: "Night Vision and Carotenoids"

Eligibility criteria:
Inclusion Criteria:

          -  No significant supplementary carotenoids within last 10 weeks. Without significant
             media opacity, cataract or congenital / acquired retinal disease other than atrophic
             AMD or diabetic retinopathy. Minimum 20/25 to enroll.

        Exclusion Criteria:

          -  Unwilling or medically / psychiatrically unable to take part in a 6 month study.

          -  Recent ophthalmologic surgery or treatment.

          -  Tricare, Retirees & Enlisted Navy Personnel excluded. Already taking an OTC product to
             improve their night vision (containing carotenoids, polyphenols like bilberry).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Assess the Efficacy and Safety of Personalized Prophylaxis Human-cl rhFVIII in Patients With Severe Haemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Severe Haemophilia A (FVIII:C < 1%)

          -  Male patients >= 18 years of age

          -  Previous treatment with a FVIII concentrate for at least 150 EDs

          -  Good documentation regarding dosing and bleeding frequency in the 6 months preceding
             study start

          -  Immunocompetence (CD4+ count > 200/uL)

        Exclusion Criteria:

          -  Any coagulation disorder other than Haemophilia A

          -  Present of past FVIII inhibitor activity

          -  Severe liver or kidney disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Primary or secondary infertility due to:

          -  Ovulatory dysfunction

          -  Mild male infertility

          -  Unexplained infertility

          -  Endometrium < 6 mm at time of hCG during previous treatment with clomiphene citrate

          -  Age 18-35

        Exclusion Criteria:

          -  Serious adverse effects under clomiphene citrate or known sensitivity to either
             tamoxifen or clomiphene citrate
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis

Eligibility criteria:
Inclusion Criteria: Patients meeting all the following criteria will be eligible for
        inclusion in the study:

          -  Age group of 18 to 75 years

          -  Clinicoradiological suspicion of sarcoidosis where EBUS-TBNA is being planned

          -  Enlarged hilar and mediastinal lymph nodes >10 mm (any axis) on computed tomography of
             the chest

          -  Ability to provide informed consent to participate in the study

        Exclusion Criteria: Patients with any of the following will be excluded:

          -  Hypoxemia (SpO2 <92% on FiO2 of 0.3)

          -  Treatment with systemic glucocorticoids for >2 weeks in the preceding three months

          -  Diagnosis of sarcoidosis possible with another minimally invasive technique such as
             skin biopsy or peripheral lymph node biopsy

          -  Failure to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction