Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Eating Behavior in Adolescents

Eligibility criteria:
-  INCLUSION CRITERIA:

        Volunteers will qualify for participation in the study if they meet the following criteria:

          1. <TAB>Age 13-17 years.

          2. <TAB>Good general health as indicated by medical history and physical examination.

          3. <TAB>Negative urine glucose and normal electrolytes, hepatic, and thyroid function.

          4. <TAB>For the fMRI portion only: right handedness (required for standardization of
             responses).

          5. <TAB>For the fMRI portion only: female.

          6. <TAB>For the fMRI portion only: overweight (BMI greater than or equal to 85th
             percentile for age and sex).

        EXCLUSION CRITERIA:

        Volunteers will be excluded if they have any of the following:

          1. <TAB>Medical problem likely to affect caloric intake.

          2. <TAB>History of any condition including psychiatric disorders in either child or their
             responsible parent that in the opinion of the investigators would impede competence to
             sign consent, interfere with adherence to procedures, or possibly hinder completion of
             the study.

          3. <TAB>Pregnancy.

          4. <TAB>Use of medication likely to affect caloric intake.

          5. <TAB>History of significant neurological injury or insult.

          6. <TAB>For the fMRI portion only: braces (or other metal) that would interfere with the
             fMRI procedure.

          7. <TAB>For the fMRI portion only: non-native English speakers (required for
             standardization of responses).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Levamisole and Isoprinosine in the Treatment of COVID19: A Proposed Therapeutic Trial

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed COVID 19 infection (positive PCR, elevated ESR, leucopenia)

          -  Clinical picture of COVID 19 infection including fever, malaise, sore throat,
             coughing, dyspnea, and runny nose

        Exclusion Criteria:

          -  Mild cases of COVID 19 that do not require hospitalization

          -  Pregnant & lactating women

          -  Children with other comorbidities

          -  People who received previous treatment for COVID 19 in the last 2 weeks N.B. Diabetes
             and hypertension not excluded
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Goal Achievement and Patient Satisfaction in Benign Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Patient undergoing hysterectomy for benign indication

          -  Age 18 or greater

          -  English speaking

          -  Access to communication via telephone

        Exclusion Criteria:

          -  Patient undergoing hysterectomy for malignant or pre-malignant condition

          -  Non-english speaking patient

          -  Patient without telephone access

          -  Patient undergoing emergent or unplanned hysterectomy

          -  Vulnerable populations
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: 'Fitness To Fly' Tests In Children With Type II Respiratory Failure

Eligibility criteria:
Inclusion Criteria:

          -  ≤18 years

          -  Neuromuscular weakness or central hypoventilation

          -  Established nocturnal or intermittent daytime ventilatory support

        Exclusion Criteria:

          -  Unable to sit in the plethysmograph

          -  Cardiac anomaly with right-to-left shunt
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: HMB- Data Collection Methods

Eligibility criteria:
Inclusion Criteria:

        Patients who are presenting for gynecologic visits or well-woman examinations who still
        have an intact uterus and are between the ages of 18 and 51 years, have abnormal uterine
        bleeding, and can read and write in English.

        Exclusion Criteria:

          -  Women who are presently on a treatment for abnormal uterine bleeding.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 51 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a rare disease, a disease of unknown prevalence, undiagnosed or an
             unaffected carrier of a rare/uncommon disease

        Exclusion Criteria:

          -  Diagnosis of a disease which is not rare
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Limb Cooling in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Age range 18 to 95 years,

          -  Clinical diagnosis of essential tremor for at least a year,

          -  A +2 or worse action or kinetic tremor of one or both upper limbs involving at least
             the forearm and/or hand

        Exclusion Criteria:

          -  Dermatologic lesions in upper limbs (e.g. skin cancer, eczema, fresh or healing
             wounds, abrasions, acne, pustules, abscesses, or skin rash),

          -  Sensory loss in the upper limbs,

          -  Known history of sensitivity to cold (i.e., cold urticaria),

          -  Known peripheral vascular disease,

          -  Raynaud's phenomenon,

          -  Scleroderma

        Healthy normal controls will be enrolled through advertisements. All controls will be
        examined to ensure that they are neurologically healthy.

        The exclusion criteria for controls will remain same as those for patient subjects.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Monitored Breathing Awareness Therapy for Insomnia Disorder in Older Adults-2

Eligibility criteria:
Inclusion Criteria: 1) Sleep onset latency > 30 min for at least 3 nights per week

        Exclusion Criteria: 1) Unable to perform tests due to inability to communicate
        verbally/blindness, inability to write and read in English (the study questionnaires are in
        English and do not exist in validated form for other languages). 2) Cognitive impairment;
        cognitively impaired patients may not be able to comply with the protocol). 3) History of a
        diagnosed non-insomnia sleep disorder, such as sleep apnea or circadian rhythm disorder 4)
        Upper extremity motor impairment that would preclude MBAT therapy (e.g., quadriplegia).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic

Eligibility criteria:
Inclusion Criteria:

          -  Students enrolled in the St. Louis Special School District.

          -  Teachers/Staff working at the 6 St. Louis Special Schools dedicated to teaching
             children with IDD.

        or

          -  Parents/ of students, teachers and/or staff employed by the St. Louis Special School
             District or Kennedy Krieger Institute schools in Maryland or

          -  Families, teachers, and staff of the 67 University Centers for Excellence in
             Developmental Disabilities (UCEDD) which is sponsored by the Association of University
             Centers for Disability (AUCD).

        Exclusion Criteria:

          -  Members of the research team will not be eligible to participate in the focus groups.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Dynamic Neck Function During Gait in Patients With Dizziness

Eligibility criteria:
Inclusion Criteria:

        Locally referred Patients to an ear-nose-and throat (ENT) clinic at an University Hospital
        for dizziness symptoms.

        Exclusion Criteria:

        Any severe neurologic or orthopedic disease affecting gait.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 67 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia

Eligibility criteria:
Inclusion Criteria:

          -  Azoospermic patients

        Exclusion Criteria:

          -  Patients with sperm cells
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment