Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Comparing Pleth Variability Index (PVI) Measurements at Different Sensing Locations

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older

          -  Undergo any type of surgeries under general anesthesia in UCI Medical Center

          -  Mechanically ventilated during surgery

          -  Arterial line placement is preferred but not required

          -  Agree to sign the consent and HIPAA forms

        Exclusion Criteria:

          -  Less than 18 years of age

          -  Pregnant women

          -  Refused to sign the consent and HIPAA forms

          -  Receive vasoactive medication prior to surgery

          -  Has these conditions: hypotension, hypothyroidism, moderate or poorly controlled
             hypertension, chronic poorly-controlled diabetes, heart failure patients, and patients
             with active airway flow obstruction, left ventricular dysfunction, intra-cardiac
             shunts, right ventricular dysfunction, atrial fibrillation, arrhythmias

          -  patients with surgeries at or around site of sensor placement

          -  Subject has skin abnormalities affecting the digits such as psoriasis, eczema,
             angioma, scar tissue, burn, fungal infection, substantial skin breakdown, nail polish
             or acrylic nails that would prevent monitoring of SpO2 levels during the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  Patient is an ambulatory, community-dwelling male or nonpregnant female and is at
             least 18 years old at the Screening Visit. Lactating females must agree not to
             breastfeed.

          -  Patient has a diagnosis of GERD and reports experiencing GERD symptoms (heartburn or
             regurgitation) on ≥ 4 days per week during the 8 weeks before the Screening Visit
             while taking standard QD PPI therapy.

        Exclusion Criteria:

          -  Patient may not meet any of the excluded conditions specified in the protocol

          -  Patient has any alarm symptoms including but not limited to GI bleeding, anemia,
             vomiting, dysphagia, or unexpected weight loss any time during the Screening or
             Pretreatment Periods

          -  Patient has a history of clinically significant hypersensitivity or allergies to any
             of the excipients contained in the study medication (active or placebo).

        NOTE: Additional inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Tidal Lavage in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain attributed to osteoarthritis for at least 1 year.

          -  Meet American College of Rheumatology clinical or clinical plus x-ray criteria for
             knee osteoarthritis

          -  Have at least a moderate pain rating on at least one of the five Western
             Ontario-McMaster University Osteoarthritis Index (WOMAC) scales

        Exclusion Criteria:

          -  Significant conditions of the spine, hips, or feet that affect the ability to walk

          -  Significant medical conditions that affect the ability to walk and function

          -  Inflammatory arthritis, such as rheumatoid arthritis or gout

          -  Degenerative arthritis secondary to other conditions, such as hemochromatosis,
             Wilson's disease, or ochronosis

          -  Current significant soft tissue rheumatism such as fibromyalgia, anserine bursitis, or
             trochanteric bursitis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children

Eligibility criteria:
Inclusion Criteria:

          -  out-patients children with diagnosis of functional constipation or have faecal
             impaction on medical history and physical examination

        Exclusion Criteria:

          -  children with organic causes for defecation disorders, such as Hirschsprung disease,
             spina bifid, hypothyroidism, or other metabolic or renal abnormalities;

          -  Children receiving medication influencing gastrointestinal motility;

          -  Children with suspected gastrointestinal obstruction or stenosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use"

Eligibility criteria:
Inclusion Criteria:

          -  Subject has been diagnosed, according to American College of Rheumatology guidelines,
             with osteoarthritis of the hip or knee and requires non-steroidal anti-inflammatory
             drugs (NSAIDs) to control their osteoarthritis pain and have access to a touch-tone
             telephone.

        Exclusion Criteria:

          -  Subject has had surgery on index joint.

          -  Subject has history of rheumatoid arthritis or fibromyalgia syndrome.

          -  Subject has active gastrointestinal or cardiovascular disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A Registered Cohort Study on Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Beyond 2 years old

          -  Diagnosis with Duchenne Muscular Dystrophy, and female carriers, genotypically
             confirmed

          -  Diagnosis should be supported by muscle biopsy, if no genetic confirmation.

        Exclusion Criteria:

          -  Presence of other clinically significant illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: VERARE_2 Efficacy of the Observation of Virtual Motor Actions for the Improvement of Gait in Patients With ICU-weakness

Eligibility criteria:
Inclusion Criteria:

          -  Patient hospitalized in one of the ICU departments or Continuing Medical or Surgical
             Care Units of the Rennes University Hospital for less than 3 months, and presenting
             muscle weakness of the lower limbs with a MRC motor test on the main muscle segments
             giving a score less than or equal to 48/60 (diagnostic criterion of ICU Weakness)

          -  Person of full age;

          -  Affiliation to a social security scheme;

          -  Free, informed and signed written consent.

        Exclusion Criteria:

          -  History of a central neurological event with clinical repercussions

          -  Gait disorders pre-existing to hospitalization in intensive care and limiting the
             walking perimeter (declaration by the patient) or requiring the use of technical
             assistance;

          -  Uncontrolled epilepsy (seizure less than 6 months old);

          -  Adults who are the subject of legal protection (safeguard of justice, curatorship,
             guardianship), persons deprived of their liberty;

          -  Non-French speaking person;

          -  Pregnant or breastfeeding woman.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Uterine Artery Ligation at Origin in Total Laparscopic Hystrectomy

Eligibility criteria:
Inclusion Criteria:

          1. Age group (35-70 years old).

          2. Women consenting to have a total laparoscopic hysterectomy.

        Exclusion Criteria:

          1. Patients with relative contraindication to general anesthesia (e.g. chronic liver cell
             failure)(All laparoscopic procedures are done under GA).

          2. Patients with contraindication to laparoscopic surgery (e.g. severe cardio-pulmonary
             dysfunction).

          3. Bleeding tendency (e.g. anticoagulants, platelets disorders)(will affect the blood
             loss measurement)

          4. Body mass index more than 35 Kg/m2(not suitable for laparoscopic surgeries as obesity
             affects airway pressure )

          5. Uncorrected anemic patients (Hemoglobin < 10 gm. /dl).(will affect the outcomes eg :

        Blood transfusion , hospital stay … etc )
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of GCA and having a diagnosis of LV-GCA confirmed by imaging
             (PET/CT)

          -  Informed consent to the local GCA cohort BARK

          -  Followed for GCA treatment in the outpatient department.

        Exclusion Criteria:

          -  Known hypersensitivity or allergy to Gadolinium (Gd)-based MRI contrast agents.

          -  Patients with cardiac pacemakers, intra cranial clips, metallic foreign bodies or
             other not MR-compatible implants (e.g. pumps etc.).

          -  Renal failure or severely impaired kidney function (eGFR < 30 ml/min /1,73 m2)

          -  Epilepsy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study

Eligibility criteria:
INCLUSION CRITERIA:

        Patients of either gender, aged 18-85 years.

        Symptomatic patients receiving clinically indicated evaluation for cardiomyopathy and found
        to have obstructive HCM.

        LV outflow tract gradient greater than 30 mm Hg at rest by echocardiography or cardiac
        catheterization.

        EXCLUSION CRITERIA:

        Positive pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment