Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Older Men and Testosterone

Eligibility criteria:
Inclusion Criteria:

          -  Men 60-80 years old

          -  Serum-testosterone levels <11.0 nmol/l

          -  Signed informed consent.

        Exclusion Criteria:

          -  Prostate cancer

          -  Breast cancer

          -  Liver tumor/cancer

          -  Unstable angina

          -  Untreated congestive heart disease

          -  Epilepsy

          -  Migraine

          -  Hematocrit >50%

          -  PSA >4.0 ug/l

          -  Serum creatinine >130 umol/l

          -  ALAT >100 U/l

          -  Known intolerance to testosterone undecanoate

          -  Participation in another research trial.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Type 3 Von Willebrand International Registries Inhibitor Prospective Study

Eligibility criteria:
Inclusion Criteria:

          -  Male and female of any age, including infants, children, adolescent and adults

          -  Informed Consent obtained (parents should sign for patients < 18 y.o.)

          -  Previous Diagnosis of VWD3 (VWF Antigen: undetectable or <5 U/dL)

          -  Detailed information on inherited pattern, history of bleeding, previous exposure to
             blood products

          -  Availability of plasma and DNA samples

        Exclusion Criteria:

        • VWD3 patients who may not be available for follow-up
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Study of Biostate® in Children With Von Willebrand Disease

Eligibility criteria:
Inclusion Criteria:

          -  Male and female subjects between 0 and <12 years of age

          -  Diagnosed with VWD Type 1, 2A, or 3

          -  Desmopressin acetate (DDAVP) treatment is ineffective, contraindicated, or not
             available for subject

          -  von Willebrand factor: ristocetin cofactor (VWF:RCo) is <20% at screening or the
             subject has a history of VWF:RCo <10%

          -  Evidence of vaccination against hepatitis A and B or presence of antibodies against
             hepatitis A and B due to either a previous infection or prior immunization

          -  Written informed consent given

        Exclusion Criteria:

          -  Active bleeding immediately prior to initial PK period

          -  Received treatment with DDAVP or a VWF concentrate product for their VWD in the 5 days
             prior to their first study treatment

          -  Have received aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) within 7
             days of commencing the PK period.

          -  Known history or suspicion of having VWF or FVIII inhibitors

          -  Acute or chronic medical condition, other than VWD, which may affect the conduct of
             the study

          -  Known or suspected hypersensitivity or previous evidence of severe side effects to
             other FVIII/VWF concentrates

          -  Participation in a clinical study or use of an investigational compound in another
             study in the 3 months preceding study start

          -  Unwillingness and/or inability to comply with the study requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure

Eligibility criteria:
Inclusion Criteria:

          -  patients with Addison's disease

        Exclusion Criteria:

          -  Type 1 diabetes

          -  malignant disease

          -  pregnant women

          -  cardiac disease

          -  lung disease

          -  neuromuscular diseases

          -  pharmacological treatment with glucocorticoids or drugs that interfere with cortisol
             metabolism (anti-epileptics, rifampicin, St Johns wart, oral estrogens,
             antidepressives).
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test

Eligibility criteria:
Inclusion Criteria:

          -  Volunteers will be in self-proclaimed good health

          -  Volunteers will be free of illness on the day of testing

          -  Volunteers will not be taking drug therapy.

          -  Patients will be free of intercurrent illness on the day of testing

          -  Patients will have a confirmed diagnosis of hypoadrenalism or hypopituitarism

        Exclusion Criteria:

          -  Is pregnant or lactating. Females of childbearing potential must have a negative
             pregnancy test before enrollment onto the study. Non-child bearing potential is
             defined as post-menopausal for at least 1 year, surgical sterilisation or hysterectomy
             at least three months before the start of the study,

          -  Is using corticosteroids,

          -  has any significant intercurrent disease,

          -  has a history of thyroid or other autoimmune disease,

          -  has a previous history of hypersensitivity to Synacthen®,

          -  has a previous history of asthma

          -  has a history of allergic disorder

          -  has any mental condition rendering the patient unable to understand the nature or
             possible consequences of the study, and/or evidence of an uncooperative attitude.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI

Eligibility criteria:
Inclusion Criteria:

          -  dysmenorrhea

          -  dyspareunia

          -  non cyclic lower abdominal pain

          -  hypermenorrhea

          -  menometrorrhaghia

          -  pain while compressing the Uterus during gyn exam

          -  Patient wants to participate

          -  Patient will receive hysterectomy

        Exclusion Criteria:

          -  Patient declines to participate

          -  contraindications against MRI

          -  contraindications against ultrasound

          -  minor

          -  cannot give informed consent

          -  no hysterectomy planned
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Patient with bleeding history sent to the Hemophilia Treatment Center in Dijon or
             Nantes University Hospital with abnormal bleeding score (>3 in men and >5 in women

          -  Patient who has provided a signed consent to participate at this study and for blood
             sampling

          -  Affiliation with French social security system

        Non-Inclusion Criteria:

          -  Minors will not be included in the study.

          -  On-going pregnancy and postpartum period (3 months after delivery)

          -  Substitutive treatment with coagulation factor concentrates or desmopressin
             administration within 10 days before sampling.

          -  Ongoing infectious or inflammatory disease that can modify VWF levels.

          -  Diagnosis of obvious hemostasis disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Efficacy and Safety of XP12B in Women With Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occurring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that may
             confound the study

          -  History of bilateral oophorectomy or hysterectomy

          -  Hormone therapy for birth control
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of the COVIDSeq Test in Saliva Specimens From COVID-19 Asymptomatic Illumina Personnel

Eligibility criteria:
Subject Inclusion Criteria:

        An individual must meet the criteria below to be eligible.

          -  Individual is Illumina US personnel (eg, employee, contractor, consultant) and was
             invited to participate in the study.

          -  Individual is 18 years or older at the time of consent.

          -  Individual is feeling well and, at the time of consent or specimen collection, does
             not have any of the following symptoms of COVID-19: cough, shortness of breath or
             difficulty breathing, fatigue, fever or chills, muscle or body aches, headache, sore
             throat, new loss of taste or smell, congestion or runny nose, nausea or vomiting, or
             diarrhea. [1]

          -  Individual is willing to participate in study procedures and able to provide written
             informed consent in the English language.

        Subject Exclusion Criteria:

        An individual cannot meet the below criteria.

          -  Individual is confirmed to have COVID-19 and continues to require home isolation in
             accordance with current CDC guidelines at the time of consent or specimen collection.

          -  Individual is asymptomatic but suspected to have COVID-19 due to recent close contact
             (as currently defined by the CDC) with a person with COVID-19 and continues to require
             quarantine in accordance with current CDC guidelines at the time of consent or
             specimen collection. [4]

          -  Individual had symptoms of COVID-19 less than 10 days before time of consent or less
             than 10 days before time of any subsequent specimen collection visit."
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction