Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height

Eligibility criteria:
Inclusion Criteria:

          -  Adult height prediction below -2.5 SD : 151 cm for girls and 164 cm for boys based on
             the vlaamse groeicurve 2004 (vub.ac.be/groeicurven)

          -  Pubertal: breast development at least M2 for girls and at least 4 ml of testicular
             volume for boys

          -  Bone age >10 years but < 12 years for girls and > 11 but < 13 years for boys

          -  Signed informed consent

        Exclusion Criteria:

          -  Adopted children ( different genetic background, lack of data on birth parameters and
             parents)

          -  Bone dysplasia or sitting height/ total height > 2 SDS on standards by Gerver et al
             (see appendix)

          -  Chronic use of glucocorticoids

          -  Previous growth promoting therapy such as GH, sex steroids, oxandrolone,

          -  Known GH deficiency

          -  Chronic infectious disease

          -  Active rheumatic disease

          -  Previously diagnosed or currently suspected malignancy

          -  Sex steroid therapy

          -  Diabetes mellitus

          -  Renal insufficiency (serum creatinine > 1.5 mg/dl)

          -  Hepatic disease ( liver test > 4 fold upper limit of normality)

          -  Current congestive heart failure

          -  Inability to follow the study protocol

          -  Treatment with a non registered drug during the last 30 days before the moment of
             inclusion.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial

Eligibility criteria:
Inclusion Criteria:

          -  Biopsy proven adenocarcinoma of the stomach

          -  Treated with palliative intent

          -  At least one index symptom such as bleeding, obstruction or pain

          -  No prior abdominal radiotherapy

          -  Not on chemotherapy

        Exclusion Criteria:

          -  Patients treated with radical intent

          -  Previous abdominal radiotherapy

          -  Patients on chemotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity

Eligibility criteria:
Inclusion Criteria:

          -  Bleeding patients.

        Exclusion Criteria:

          -  Coagulation defects, and those on anti-platelet drugs.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Study on the Effects of Exogenous Testosterone on Threat Perception and Behavioral Avoidance

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  In good health

          -  Aged 18-35

        Exclusion Criteria:

          -  Female

          -  Known carcinoma of the breast or prostate

          -  Known sensitivity to alcohol or soy products

          -  Preexisting cardiac, renal, or hepatic diseases

          -  Obesity

          -  Chronic lung diseases

          -  Cancer

          -  Use of anticoagulants

          -  Use of insulin or a history of diabetes

          -  Use of corticosteroids

          -  High levels of physical contact with women or children

          -  Preexisting liver problems
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Study of Laparoendoscopic Single Site Hysterectomy in Benign and Preinvasive Uterine Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patient who undergo laparoscopic assisted vaginal hysterectomy due to following
             gynecologic disease

               1. uterine leiomyoma

               2. uterine adenomyosis

               3. Endometrial hyperplasia

               4. cervical intraepithelial neoplasia including carcinoma in situ and FIGO stage IA1
                  cancer

               5. Dysfunctional uterine bleeding

               6. Other benign gynecologic disease requiring hysterectomy

          -  American Society of Anesthesiologists Physical Status classification I-II

          -  Patient who have signed an written informed consent

        Exclusion Criteria:

          -  Uncontrolled medical disease

          -  Active infectious disease

          -  Previous pelvic radiation therapy

          -  Patient who requiring further procedure excluding hysterectomy, unilateral or
             bilateral salpingooophorectomy / salpingectomy / oophorectomy

          -  Patient who undergoes subtotal hysterectomy

          -  Patient who have other pain source excluding gynecologic disease

          -  Pregnancy and lactating woman
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Project Osteoarthritis: Recovering Quality of Life Through Education

Eligibility criteria:
Inclusion Criteria:

          -  Men and women diagnosed with primary or secondary osteoarthritis of the
             knees,classified as grades I to IV Kelgreen and Lawrence (KL), ie, any degree of knee
             osteoarthritis

        Exclusion Criteria:

          -  Patients who have psychiatric or neurological disorders, whose symptoms during the
             evaluation to the school are related or significantly interfere in the functions of
             attention, memory, logical reasoning, understanding and interaction with the group in
             order to undermine the assimilation of the guidelines given
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Does 3D Laparoscopy Improve Vaginal Cuff Suture Time?

Eligibility criteria:
Inclusion Criteria:

          -  Women with benign conditions such as uterine fibroids, menorrhagia, adenomyosis,
             pelvic pain, abnormal uterine bleeding

        Exclusion Criteria:

          -  None
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Exercise Training in Sarcoidosis (EXTRAS Study)

Eligibility criteria:
Inclusion Criteria:

          -  Main diagnosis: previously diagnosed sarcoidosis according to the latest ATS/ERS/WASOG
             statement on sarcoidosis (AJRCCM 1999)

        Exclusion Criteria:

          -  A history of neurosarcoidosis

          -  Undergoing structured exercise training at the time of enrollment or in the preceding
             6 months

          -  Current participation in a pharmacological study

          -  Cardiovascular abnormalities on the ECG during baseline peak exercise test

          -  A 'normal' baseline peak oxygen uptake (≥90% of the predicted values) in combination
             with a 'normal' quadriceps peak torque or distance walked in 6 minutes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Relationship Between the Menstrual Cycle and Heart Disease in Women

Eligibility criteria:
Inclusion Criteria:

          -  Normal menstrual cycles of 25-35 days in length for at least previous 3 cycles

          -  21-40 years of age

          -  BMI > 18, < 30

          -  Serum P4 > 9 ng/ml on single sample collected between days 18-25 of self-reported
             menstrual cycle

          -  Flexible schedule allowing morning blood draws on less than 48 hour notice

          -  In good general health

          -  Commit to remain on stable diet during study period (no changes to normal dietary
             habits)

          -  Commit to using non-hormonal contraceptive methods during study period except those
             prescribed in the experimental protocol

          -  No objections to taking study drugs

        Exclusion Criteria:

          -  Oral contraceptive use or other hormone supplement within the preceding 2 months

          -  Long-acting hormonal contraceptive use in the past 12 months (e.g., Depo-Provera®)

          -  Contraindications to study drugs

          -  Current or past pregnancy within the previous 6 months or currently trying to conceive

          -  Desiring to conceive in the next 8 months

          -  Breastfeeding in the past 2 months

          -  Diagnosed Diabetes or Metabolic Syndrome

          -  Current or previous use of cholesterol lowering drugs within the preceding 12 months

          -  Diagnosed Polycystic Ovary Syndrome

          -  History of, or self-reported, substance abuse

          -  Smoker

          -  Previous infertility treatment excluding male factor issues

          -  Use of an investigational drug within the past 2 months
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Vaginal Creams to Reduce Vaginal Erosion in Pessary Users

Eligibility criteria:
Inclusion Criteria:

          -  Age >/= 18 years

          -  Female gender

          -  >/= Stage II pelvic organ prolapse

          -  Clinical diagnosis of pelvic organ prolapse and desiring non-surgical management with
             pessary

          -  Ability to provide informed consent and complete all study requirements

        Exclusion Criteria:

          -  Life expectancy < 12 months

          -  Current pregnancy

          -  Patients will undergo a urine pregnancy test

          -  Already using vaginal estrogen

          -  Limited manual dexterity

          -  History of vaginal erosion with prior pessary use

          -  All patients with a past or present diagnosis of Breast cancer

          -  Patients with any pathology of the female reproductive organs

          -  Patients with undiagnosed abnormal genital bleeding

          -  Patients with known or suspected estrogen-dependent neoplasia

          -  Active deep vein thrombosis, pulmonary embolism or history of these conditions

          -  Active or recent (within last year) arterial thromboembolic disease

          -  Patients with liver dysfunction or disease

          -  Patients with known hypersensitivity to Estrace's ingredients
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction