Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Molecularly confirmed diagnosis of Fragile X Syndrome

          -  Molecularly confirmed diagnosis of Williams-Beuren Syndrome

          -  Autism features

          -  Score > or = 4 in Clinical Global Impression (Guy et al., 1976)

        Exclusion Criteria:

          -  Parent yet enrolled in a parent training during first evaluation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 7 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Short-Term Androgen Priming Before COS Using Aromatase Inhibitor and hCG During Early-Follicular-Phase GnRH Antagonist Administration - a Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Indication and wish for IVF/ICSI treatment

          -  Womens age 20-39 years (both inclusive)

          -  Regular menstrual cycle within normal range

          -  Body Mass Index: 18-30 kg/m2 (both inclusive)

          -  Negative pregnancy test before treatment

          -  A maximum of 3 earlier IVF/ICSI treatments that did not result in pregnancy

        Exclusion Criteria:

          -  serious systemic disease

          -  Presence of polycystic ovarian syndrome (PCOS)

          -  Earlier poor response with less than 4 mature follicles

          -  Earlier participation in the investigation
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Efficacy and Safety Study of XP12B in Women With Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occurring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that may
             confound the study

          -  History of bilateral oophorectomy or hysterectomy

          -  Hormone therapy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: PDE Inhibitors in DMD Study (Acute Dosing Study)

Eligibility criteria:
Inclusion Criteria:

          1. diagnosis of DMD confirmed by muscle biopsy or DNA analysis

          2. age 7-15y

          3. ambulatory

          4. no clinical evidence of heart failure

        Exclusion Criteria:

          1. hypertension, diabetes, or heart failure by standard clinical criteria

          2. elevated BNP level (>100 pg/ml)

          3. LVEF < 50%

          4. non-ambulatory

          5. cardiac rhythm disorder, specifically: rhythm other than sinus, SVT, atrial
             fibrillation, ventricular tachycardia

          6. continuous ventilatory support

          7. liver disease

          8. renal impairment

          9. contraindications to sildenafil (use of nitrates, alpha-blockers, CYP3A inhibitors,
             amlodipine, or other PDE5A inhibitors)
Male
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Effect of Placing the Implant Crown on the Implant on the Same Day as the Implant vs. 4 Weeks Later.

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 20 years

          -  Willingness to sign informed consent and to participate in the study

          -  Plaque index according to Silness and Loe of < 35% [26]

          -  Presence of a mandibular first molar that has to be extracted

          -  Sufficient vertical interocclusal space for the placement of an implant crown (7 mm)

          -  Presence of an opposing natural or artificial tooth

          -  Ridge height sufficient for the placement of a ≥ 10 mm-long implant

          -  Sufficient ridge width for the placement of a 4.1mm diameter implant

        Exclusion Criteria:

          -  Any physical or mental disorder that would interfere with the ability to perform
             adequate oral hygiene or the capability of providing written informed consent and
             compliance to the protocol

          -  Any disorder that would interfere with wound healing or represent a contraindication
             for implant surgery such as, but not limited to, uncontrolled diabetes or conditions
             resulting in or requiring immunosuppression, radiation, chemotherapy, frequent use of
             antibiotics or antiresorptive medication such as bisphosphonates

          -  Pregnancy or lactation

          -  Intention to become pregnant between inclusion and implant loading

          -  Heavy smoking habit with ≥ 10 cig/d

          -  Severe bruxism or clenching habits, present oro-facial pain

          -  Insufficient ridge width/height for the study implant

          -  Defect of any alveolar wall (secondary exclusion criterion at tooth extraction)

          -  ISQ < 70 (secondary exclusion criterion for Group A at implant placement, for Group B
             at loading visit)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Characterization of Influenza-like Illness in Mexico

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent by participant, or for pediatric participants, signed informed
             consent by parent/legal guardian and, where appropriate, signed assent by participant

          -  At least one respiratory symptom (e.g., shortness of breath, postnasal drip, cough)
             and

          -  One of the following criteria:

          -  Fever (≥ 38 °C by any method: oral, axillary, etc.) on examination or
             participant-reported fever (≥ 38° C) or feverishness in the past 24 hours

          -  One or more non-respiratory symptoms (e.g., malaise, headache, myalgia,chest pain)

          -  Consenting to provide aspirate or naso-pharyngeal swab

        Exclusion Criteria

          -  The onset of illness is more than 48 hours after hospitalization.

          -  Participants previously included in this study within the last 30 days.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Compare the Effects of Telemedicine Approach With Usual Care in Hypertension Management in China

Eligibility criteria:
Inclusion Criteria:

          1. age 21 years or older

          2. a clinical diagnosis of hypertension with uncontrolled BP in the previous three
             months, currently taking or about to take anti-hypertensive medications

          3. received high school or above level of education

          4. active user of smart phone (Android or Apple) and mobile Apps

          5. the average of three BP measurements during the screening visit at the CHC is ≥ 140/90
             mm Hg, or ≥ 130/80 mm Hg if the patient has diabetes or renal diseases;

          6. being able to give informed consent.

        Exclusion Criteria:

          -  acute coronary syndrome

          -  heart failure

          -  cardiac arrhythmia

          -  stroke within the past three months

          -  renal failure

          -  cancer

          -  dementia, severe or acute psychiatric illness, pregnancy or intention to be pregnant
             in the next 18 months, and hospitalization within 3 months.

          -  additional exclusion criteria include participation in another clinical trial, arm

          -  circumference >32 centimeters that may affect the accuracy of BP measurement due to
             cuff size limit of the tele-monitor's, and unwillingness to comply with the 12 month
             intervention duration.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: NOWDx Test for the Detection of Antibodies to COVID-19 in Lay Persons

Eligibility criteria:
Inclusion Criteria:

        Innate Infection Cohort>

          -  PCR positives: persons who were symptomatic for COVID-19 and have tested positive for
             COVID-19 with an EUA or FDA cleared PCR test; 7+ days post positive PCR test

          -  PCR negatives: persons who have never had COVID-19 and who have tested negative for
             COVID-19 with an EUA or FDA cleared PCR test; within 0-6 days post negative PCR test

          -  persons 2+ years old

        Vaccination Cohort>

          -  persons 7- 60 days post second dose of EUA COVID-19 vaccine

          -  persons 18+ years old

        Exclusion criteria:

        Innate Infection Cohort>

          -  PCR positives: persons with a COVID-19 positive test result >45 days old

          -  PCR negatives: persons with any prior COVID-19 positive result

          -  persons who have received COVID-19 vaccine

          -  persons <2 years old

        Vaccination Cohort>

          -  persons symptomatic or previously infected with COVID-19 prior to vaccination

          -  persons <18 years old
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Rescue Immunotolerance Study in Induction of Immune Tolerance (ITI)-Experienced Patients (RES.I.S.T. Experienced)

Eligibility criteria:
Inclusion Criteria:

          1. severe hemophilia A (FVIII<1%) with high responding inhibitors (peak levels >5 BU)

          2. male, any age;

          3. any inhibitor level at study enrollment;

          4. ability and willingness to participate to the study;

          5. previous ITI course of at least 9 months with a VWF-free FVIII concentrate at any
             dosage, such as recombinant FVIII and/or monoclonally purified FVIII.

        Exclusion Criteria:

          1. concomitant systemic treatment with immunosuppressive drugs;

          2. concomitant experimental treatment;

          3. previous history of myocardial infarction and/or cerebral stroke
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities

Eligibility criteria:
Inclusion Criteria:

          -  Literate mothers with physical disabilities or healthy children between the ages of 4
             and 16, without any known functional and psychological problems

          -  Literate mothers aged 4-16 years with healthy children, without any known functional
             and psychological problems

          -  Signed informed consent form

        Exclusion Criteria:

          -  Mothers of 20 healthy children will be included. with the children who have multiple
             disabilities

          -  Mothers of 20 healthy children will be included. with the children who have severe /
             moderate mental impairment

          -  Mothers of 20 healthy children will be included. with the children who have Down's
             syndrome or autism
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 24 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment