Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Comparison of Effectiveness Between PL and PRP on Knee Osteoarthritis: a Prospective,Randomized,Placebo-controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  50 to 80 years old

          -  Study Subjects must be willing to sign Informed Consent to participate in the study

          -  In the past month, at least seven consecutive days in the squat, standing, walking or
             going up and down the stairs, the most serious degree of visual analogy of the knee
             pain (Visual Analogue Scale) is greater than or equal to 40 (the most pain is 100, not
             painful is 0)

          -  Morning joint stiffness is less than 30 minutes

          -  X-ray：Grade 1-3 radiographic OA as defined by the K-L classification

        Exclusion Criteria:

          -  Knee instability

          -  The knee joint is obviously deformed (> 5 degree valgus or varus deviation on X-ray)

          -  Clinical diagnosed as Pes tendinitis, Chondromalacia

          -  Taking NSAIDs or steroids (including oral and injection) within one week

          -  Using anticoagulant drugs for a long time

          -  Platelet count is less than 150,000 / UL, or coagulation disorders, prothrombin time
             (PT value) is less than 11 seconds or greater than 16 seconds

          -  Leukemia, sepsis, platelet dysfunction or other blood related diseases

          -  tumors, infections or the trauma before the same site

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment