Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia

Eligibility criteria:
Inclusion Criteria:

          1. Male and female patients between 20 to 80 years old

          2. Patients with at least one condition below

               -  Systolic blood pressure is 140mmHg or higher, or diastolic pressure is 90mmHg or
                  higher, and 2 or more cardiovascular risk factor, and low-density lipoprotein
                  cholesterol is 130mg/dL or higher.

               -  Systolic blood pressure is 140mmHg or higher, or diastolic pressure is 90mmHg or
                  higher, and 0 or 1 cardiovascular risk factor, and low-density lipoprotein
                  cholesterol is 160mg/dL or higher.

               -  Patients with medication for hypertension, and (a) symptomatic coronary artery
                  disease, stroke, peripheral artery disease regardless of low density lipoprotein
                  cholesterol level, or (b) diabetes mellitus, carotid artery stenosis of 50% or
                  higher, aortic aneurysm with low density lipoprotein cholesterol 100mg/dL or
                  higher, or (c) more than 2 cardiovascular risk factor with low density
                  lipoprotein cholesterol 130mg/dL or higher, or (d) 0 or 1 cardiovascular risk
                  factor with low density lipoprotein cholesterol 160mg/dL or higher

               -  Patients with medication for dyslipidemia, and systolic blood pressure is 140mmHg
                  or higher or diastolic blood pressure is 90mmHg or higher

               -  Patients with medication for hypertension and dyslipidemia

          3. Patients who can understand the provided information, and sign the consent form

        Exclusion Criteria:

          1. Systolic blood pressure is 180mmHg or higher, or diastolic blood pressure is 100mmHg
             or higher

          2. Patient with endocrinologic or metabolic disorder which could affect serum lipid or
             lipoprotein

             - Uncontrolled diabetes mellitus (HbA1c result at baseline evaluation is 9% or higher,
             or fasting glucose is 160mg/dL or higher

          3. Severe cardiologic disorder (heart failure with NYHA class 3 or 4, heart attack in 6
             months, myocardial infarction, heart surgery, percutaneous coronary intervention,
             unstable angina) or coronary artery bypass surgery in 3 months

          4. Clinically significant ventricular tachycardia, atrial fibrillation, atrial flutter or
             other clinically significant cardiac arrhythmia judged by the researcher

          5. Patient with genetic disease such as galactose intolerance, Lapp lactase deficiency,
             or glucose-galactose malabsorption

          6. Patient with psychotic disease, or drug or alcohol addiction

          7. Patient with severe liver cirrhosis, renal failure, or heart failure

          8. Patient with systemic infectious disease

          9. Patient who had systemic steroid (intravenous, intramuscular, or per oral) within 2
             months before screening, or planned to

         10. Patient in pregnancy, lactation, or childbearing age without proper contraceptive
             measure

         11. Patient who attended other clinical trial 1 month before screening

         12. Patient who seems to be inappropriate to be in clinical trial judged by researcher
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment