Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years and ≤ 65 years

          -  Important essential tremor (bilateral postural and/or action tremor since more than
             one year)

          -  Normal physical and neurological examination, except for essential tremor

          -  Insufficient efficiency of usual essential tremor's treatment

          -  No treatment altering the cortical excitability

          -  Agreement to use a medically acceptable method of contraception throughout the study
             for female of childbearing potential

          -  mini-mental status score >24

        Exclusion Criteria:

          -  Age < 18 years and > 65 years

          -  Current neurological or psychiatric illness other than essential tremor

          -  Individual who is on medication which is known to lower seizure threshold

          -  Previous history of seizure, loss of conciousness or current active epilepsy

          -  Contraindication for MRI or TMS study

          -  Intake of antiepileptic medications for essential tremor (barbiturates, gabapentine,
             topiramate, clonazepam), within the 7 days preceeding the first visit

          -  alcohol intake within the 24 hours preceeding the first visit

          -  Pregnancy, breast feeding women and women who are of childbearing age and not
             practicing adequate birth control

          -  Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide
             an informed consent

          -  Simultaneous participation in another clinical trial

          -  Patients who are not enrolled at social security
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment