Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: The Effect of PTH(1-84) or Alendronate on Reduction of Back Pain in Postmenopausal Women With an Osteoporosis Related Vertebral Fracture(s) (FP-005-IM)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women with a T-score ≤ -1.5 SD and at least one osteoporosis related
             vertebral fracture. Chronic back pain.

        Exclusion Criteria:

          -  Previous/current treatment and medical history.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: CEQUA for Sjogren's Syndrome Dry Eye

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Sjogren's Syndrome.

          -  Self-reported complaints of ocular dryness for a period of at least 3 months

          -  Best-corrected distance visual acuity of 20/25 or better in each eye.

        Exclusion Criteria:

          -  Use of cyclosporine within the last 3 months.

          -  Use of ocular steroid within the 3 months.

          -  Previous history of treatment failure with cyclosporine.

          -  Known hypersensitivity or contraindication to the study medication or any of its
             ingredients.

          -  Use of any systemic or topical ocular medication that is known to cause or exacerbate
             dry eye.

          -  Any active ocular infection.

          -  Severe or serious ocular condition in either eye or any other unstable medical
             condition that may preclude study treatment or follow-up.

          -  History or presence of chronic generalized systemic disease that might increase the
             risk to the subject or confound the results of the study.

          -  Currently pregnant or lactating.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male or female subjects in good health as determined by past medical history

          -  physical examination, vital signs and safety lab at screening

          -  between 18 to 45 years of age

        Exclusion Criteria:

          -  Significant illness

          -  pregnant or lactating women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Study To Assess the Quality and Strength of Bone in Women Participants With Osteoporosis Taking Oral Ibandronate Versus Placebo

Eligibility criteria:
Inclusion criteria:

          -  Ambulatory, postmenopausal women between the age of 55 to 80 years diagnosed with
             osteoporosis

          -  BMD T-Score less than or equal to (<=) -2.0 at total spine or total femur or total
             neck, and BMD T-score greater than or equal to (>=) -5.0 at all 3 sites

        Exclusion criteria:

          -  Have been treated with other bisphosphonates or using chronic steroids within the past
             6 months

          -  Have a history of major upper gastrointestinal (GI) diseases or have severe kidney
             dysfunction

          -  Have a spine fracture (identified on X-ray)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Assessment of the Presence of the SARS-COV-2 Virus in the Peritoneum of COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years old

          -  Patient COVID-19 diagnosed by positive RT-PCR SARS-CoV-2 for less than 10 days, or by
             thorax CT-scan suggesting specificdiagnostic aspects of COVID-19 requiring abdominal
             or gynecological surgery by emergency laparoscopy

        OR

          -  Patient COVID-19 suspected requiring abdominal or gynecological surgery by emergency
             laparoscopy. Suspicion will be defined by the presence of at least one of the
             following symptoms:

          -  Cough for less than 15 days

          -  Fever which appeared recently and which excluded another etiology

          -  Anosmia without obstructive rhinitis

          -  Contact with a COVID-19 + case person less than 21 days ago

          -  Patient requiring abdominal or gynecological surgery by emergency laparoscopy and who
             should be tested by RT-PCR SARS-CoV-2

          -  Written and signed consent of the patient or guardian or family or, if this is not
             possible, emergency inclusion procedure

          -  Patients with affiliation to French social security system

        Exclusion Criteria:

          -  Patient already participating in research involving the human person

          -  Negative RT-PCR SARS-CoV-2

          -  Withdrawal of patient or guardian or family; or refusal to sign the required inform
             consent form to continue to participate in the Clinical Trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: The Role of Attention Focus Walking Training in Older Adults.

Eligibility criteria:
Inclusion Criteria:

          -  Age 65 or above;

          -  No history of cerebral vascular disease, Parkinson's disease or other neurological
             deficit;

          -  Chinese version of the Mini-Mental State Examination (MMSE-C) total score of equal or
             more than 24;

          -  Able to walk independently indoor for at least 40 meters continuously with comfortable
             pace;

          -  Older adults with moderate to high risk of falling, as indicated by the score of less
             than 24 out of 28 in the Tinetti Balance Assessment Tool.

        Exclusion Criteria:

          -  Any potential participant who cannot meet the inclusion criteria.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial

Eligibility criteria:
Inclusion Criteria:

          -  All consecutive ASA grade I-II- III patients undergoing elective unilateral
             laparoscopic total extra peritoneal (TEP) Inguinal hernia repair

          -  Age 18 - 80 yrs, including those who are having recurrent inguinal hernia repair.

        Exclusion Criteria:

          -  ASA grade IV, V

          -  Bilateral inguinal hernia repair

          -  BMI > 40 kg/m2

          -  Converted to open procedures.

          -  Conversion to Transabdominal preperitoneal (TAPP) repair

          -  Coagulopathy.

          -  Allergy to Bupivacaine.

          -  Diagnosis of "chronic pain syndrome".

          -  Known alcohol or substance abuse within the last 6 months.

          -  Daily Opioid intake.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Study of Crenolanib With Ramucirumab and Paclitaxel for Advanced Esophagogastric Adenocarcinoma

Eligibility criteria:
Inclusion Criteria:

          -  Pathologically confirmed adenocarcinoma of the esophagus, GEJ or stomach.

          -  Stage IV disease or locally advanced/unresectable tumors

          -  Prior progression on only 1 line of chemotherapy in the advanced/metastatic setting
             containing a fluoropyrimidine and/or platinum compound

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

        Exclusion Criteria:

          -  Prior treatment with a taxane is not permitted in the dose-expansion phase. Patients
             in the dose escalation component may have received a taxane in the peri-operative
             setting, provided they developed disease recurrence >6 months after the completion of
             this therapy

          -  Known pre-existing liver disease (e.g. cirrhosis, chronic hepatitis B or C,
             nonalcoholic steatohepatitis, sclerosing cholangitis)

          -  Patients with any clinically apparent ascites or who have undergone a paracentesis
             within 7 days of enrollment

          -  Uncontrolled hypertension (systolic pressure >140 mm Hg or diastolic pressure > 90 mm
             Hg on repeated measurement) despite optimal medical management

          -  Active or clinically significant cardiac disease

          -  Patients with arterial thrombotic events, such as cerebrovascular accident or
             myocardial infarction, within 6 months of enrollment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Assessment of Cough and Wheeze With Breath Sound Documenting Device

Eligibility criteria:
Inclusion Criteria:

          -  Patient and/or parents/guardian signed informed consent

          -  Patients with cough or shortness of breath

        Exclusion Criteria:

          -  Chest tubes

          -  Skin lesions precluding attachment of sensors

          -  Respiratory distress

          -  Pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Clinical Study to Investigate the Pharmacokinetics, Efficacy, Safety and Immunogenicity of a Recombinant FVIII in Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A (FVIII:C <= 1%)

          -  Male subjects between 12 and 65 years of age

          -  Body weight 25 kg to 110 kg

          -  Previously treated with FVIII concentrate for at least 150 EDs

        Exclusion Criteria:

          -  Other coagulation disorder than hemophilia A

          -  Present or past FVIII inhibitor activity
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction