Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Controlled Ovarian Hyperstimulation (COH) With Sequential HPFSH & HMG Versus Rec-F.S.H Alone in ICSI Cycle

Eligibility criteria:
Inclusion Criteria:

          -  1-Aged 20-35 yr, male factor, 2-Tubal or unexplained infertility, 3-regular
             menstruation cycle between 21 and 35 days, 4-Normal function of uterus according to
             hysterosalpingography, hysteroscopy or transvaginal ultrasonography, 5-Normal ovaries
             according to transvaginal ultrasonography during past 6 months prior to study and
             compatible with normal adnexa and 6-Normal ovarian anatomy, and serum FSH level less
             than 8 IU/l All women showed no recognizable endometriosis according to symptoms and
             clinical examination in transvaginal ultrasonography or diagnostic laparoscopy.
             7-7-All women have a history of unexplained infertility 8-Normal ovulatory function
             and normal semen analysis according to the World Health Organization criteria .

        Exclusion Criteria:

          -  Patients with other ovulation disorders such as hypo and hypergonadotropic,
             hypogonadism, hyperprolactinemia.

             2-Thyroid disorders. 3-Ovarian or adrenal neoplasms. 4-Cushing syndrome. 5-previous
             history of systemic diseases such as endocrine and metabolic disorders.

             6- Previous history of inappropriate ovarian response to stimulation with
             gonadotropins (poor responders).

             7-Prior history of more than 3 unsucce
Female

Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis

Eligibility criteria:
Inclusion Criteria:

        Premenopausal women aged 30 - 50 years old scheduled for vaginal, abdominal or laparoscopic
        total hysterectomy one or more of the following clinical symptoms:

          -  bleeding disorders (menorrhagia, irregular bleeding, hypermenorrhoea),

          -  chronic pelvic pain,

          -  dysmenorrhoea,

          -  or dyspareunia junction zone definable

        Exclusion Criteria:

          -  postmenopausal women,

          -  pregnancy

          -  gynecological cancer

          -  GnRH analog therapy or systemic hormone therapy in the last three months prior to
             hysterectomy

          -  junctional zone not identifiable
Female
Accepts Healthy Volunteers
Subject must be at least 30 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Sensory Effects of Rapidly-Changing Magnetic Fields

Eligibility criteria:
Inclusion Criteria:

          -  Adults over 18, capable of informed consent

        Exclusion Criteria:

          -  History of arrhythmia. Has implanted pacemaker or defibrillator, right
             wrist-to-sternum distance of less than 60 centimeters, visible tattoos of the right
             hand or wrist, or with any metallic objects that cannot be removed from the right hand
             or wrist. Irregular or imperceptible pulse. Heart rate less than 50 beats per minute
             or more than 100 per minute, resting respiratory rate greater than 25 per minute,
             diastolic blood pressure less than 50. Solid meal ingested within 2 hours prior to the
             study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Influence of Wrist Taping on Handgrip Strength in Crossfit Athletes

Eligibility criteria:
Inclusion Criteria:

          -  be an amateur practitioner of the Crossfit modality with at least 6 months of regular
             sports practice (at least 4 times a week)

          -  between 18-40 years old

          -  agree to participate in the study and sign the informed consent form (ICF).

        Exclusion Criteria:

          -  active wrist/ arm injury or pain on the day of the test (pain score greater than 3 in
             10 for both shoulder, forearm, wrist and / or hand on the VAS pain scale)

          -  history of wrist injury (especially fracture or ligament injury)

          -  previous wrist surgery
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Corticosteroid Intra-articular Injection in Hands Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Hand OA

          -  Age over 40

          -  Visual analogic scale (VAS) for pain at rest between 3-8cm

          -  Signed informed consent term

        Exclusion Criteria:

          -  Change in the use of oral corticosteroid or nonsteroidal antiinflammatory (NSAID) in
             the last 30 days

          -  Change in drugs for OA in the last two months

          -  IAI in this joints in the last three months

          -  Any change in treatment for OA in the hands in the last two months

          -  Suspicion of local and or systemic infection, and pregnancy

          -  Hands X-ray suggesting arthropathy of the interphalanges of other etiology

          -  Serious coagulation disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: EVALUATION OF THE EFFECT OF THE PERFECTA V-BEAM LASER ON ROSACEA

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must have a Fitzpatrick skin type of I-IV and have Rosacea as evaluated by
             the treating physician.

          -  Subjects must have visible telangiectasia on the side of the face.

          -  Subjects must be willing and able to comply with all follow-up requirements.

          -  Subjects must be willing and able to apply sunblock SPF of 30 while exposed to the
             sun.

          -  Subject willing to have photographs taken and used in presentations or publications.

        Exclusion Criteria:

          -  Subjects must not have had a previous laser treatment, deep chemical peel in the
             intended treatment site(s) within 6 months prior to treatment, oral retinoids within 6
             months of their inclusion into this study or have ever taken gold therapy.

          -  Subjects must not have a history of keloid formation.

          -  Subjects with Fitzpatrick Classification of V or VI (to reduce the risk of
             hyper-pigmentation).

          -  Subjects must be willing and able to comply with all follow-up requirements.

          -  Subjects cannot have vitiligo, a condition where pigment is lost in the skin and white
             patches appear).

          -  Subjects not willing to avoid sun exposure or not will to apply sunblock SPF of 30
             while exposed to the sun.

          -  Subject not willing to have photographs taken and used in presentations, publications
             and marketing material
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects 18 to <65 years old with severe hemophilia A or B with or without
             inhibitors to FVIII or FIX.

          -  Subjects is willing and able to comply with the mandatory washout periods prior to
             screening and prior to dosing and through 48 hours post dosing. At screening this
             includes a washout of FIX for 96 hours and FVIII for 72 houts. At dosing this includes
             a washout of FIX for 96 hours and FVIII and other hemostatic agents for 72 hours
             through 48 hours post dosing.

          -  Subjects must agree and commit to using a a highly effective method of birth control
             from the time of screening through four weeks after study drug administration.

        Exclusion Criteria:

          -  Presence of a bleeding disorder in addition to hemophilia A or B.

          -  Regular, concomitant therapy with immunomodulating drugs (eg, intravenous
             immunoglobulin, and routine systemic corticosteroids).

          -  History of coronary artery disease, thrombolic disease or diagnosis of prothrombic
             disorder.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: An Efficacy and Safety Study of ABT-SLV176 for the Treatment of Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

        Low testosterone

        Exclusion Criteria:

          -  Normal testosterone levels

          -  Elevated Prostatic Specific Antigen (PSA)

          -  History of breast or prostate cancer
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: A Drug-drug Interaction Study Between BMS-663068 and Oral Contraceptives in Healthy Female Volunteers (DDI)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy female nonsmoking subjects, ages 18 to 40 years, inclusive with a body mass
             index of 18.0 kg/m2 to 32.0 kg/m2, inclusive

          -  Women of child bearing potential with intact ovarian function by medical history and
             history of regular menstrual cycles must have been on a stable regimen of combination
             oral contraceptives containing EE and progestin (28 day regimen) without evidence of
             breakthrough bleeding or spotting for at least 2 consecutive months prior to Day -1

        Exclusion Criteria:

          -  Any significant acute or chronic medical illness

        Other protocol defined exclusion criteria could apply.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction