Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Stretching Exercises on Symptoms of Primary Dysmenorrhea

Eligibility criteria:
Inclusion Criteria:

          -  BMI of 20-29.9 kg/m2,

          -  regular menstrual cycle

          -  length 28-30 day

          -  cycle bleed from 3 to 7 days,

        Exclusion Criteria:

          -  contraindication to stretching exercise

          -  taking any hormonal medications:

          -  smoker
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 23 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Brain Fitness APP for Cognitive Enhancement

Eligibility criteria:
Inclusion Criteria:

          -  Age: 20+ years

          -  Have a score of 7≤ MoCA ≤ 25

          -  Being diagnosed with either mild cognitive impairment (MCI) or mild/moderate stage of
             Alzheimer's.

          -  Except the MCI/Alzheimer's diagnosis, have no known or diagnosis of major depression,
             bipolar disorder, schizophrenia, mood disorder, Parkinson's disease, Huntington
             disease, ALS, MS, and/or any other neurological disorder.

          -  Reading/writing fluency in English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: The Impact of Patient Complexity on Healthcare Utilization

Eligibility criteria:
Inclusion criteria for clinics: Clinics must be a clinic that offers Primary Care (Family
        Medicine Clinics, Pediatrics Clinics, General Practice Clinics, Internal Medicine clinics
        that are not limited to a subspecialty focus, and multi-specialty clinics that include
        primary care providers as part of a comprehensive care team.) Clinics must have implemented
        their EHR by 1/1/2014.

        Inclusion criteria for patients: EHR Patients must be established patients within a health
        care system: at least one ambulatory visit to an included clinic in 2015 and at least 1
        visit to a primary care clinic within the same health system prior to that visit.

        Inclusion criteria for patients for Medicaid based Outcomes: Patient must have been
        continuously covered by Medicaid in 2015 and have had at least 1 visit billed as an office
        visit in 2015 with a provider identified as a primary care provider and at least 1 prior
        claim billed to the same provider. Patients must meet the age/condition criteria for the
        assessment of at least 1 secondary outcome.

        Exclusion Criteria:

        Exclusion criteria for patients: Patients with no geocoded address on file will be excluded
        from the analysis.

        Exclusion criteria for patients for Medicaid based Outcomes: Patient with Medicaid coverage
        gaps of >45 days will be excluded from theses analyses. Exclusion criteria for providers:
        Providers with <20 patients in any Quality metric denominator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Comparison of the Operation and Medical Treatment of Endometriosis and Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients who underwent endometriosis or adenomyosis-related surgery in the
             investigator's hospital from 2005/01/01 to 2018/12/31, and received follow-up
             medication.

        Exclusion Criteria:

          -  None
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Evaluation of the Effectiveness of Night Orthosis in Treating Women With Symptomatic Osteoarthritis in the Interphalangeal Joint of the Dominant Hand

Eligibility criteria:
Inclusion Criteria:

          -  Women aged between 40 and 80 years.

          -  Patients diagnosed with osteoarthritis (OA) hand according to the American College of
             Rheumatology classification criteria.

          -  Pain symptom in proximal interphalangeal (PIP's) or distal interphalangeal (DIP's)
             dominant hand in II and III or fingers.

          -  Provide greater pain symptom of II and III or fingers between each other.

          -  Complains of pain symptom measured by a visual analog scale (VAS) pain between 3 to 8
             cm in the II and III or fingers of the dominant hand reported to perform joint
             movement (activity).

          -  Thumb abduction with the II and III fingers without changing the pincer movement
             pulp-pulp.

        Exclusion Criteria:

          -  Other rheumatic diseases, neurological and skeletal muscle that can affect the upper
             limb.

          -  Fibromyalgia uncontrolled.

          -  Pregnancy.

          -  Geographical inaccessibility and transport.

          -  Cognitive impairment that prevents the understanding of assessment tools.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of osteoarthritis

          -  Eligible for a unilateral or bilateral primary TKA to be performed by Dr. Michael
             Dayton (University of Colorado Hospital)

          -  Minimum of 110 degrees of active knee flexion

          -  No greater than 10 degrees of anatomic knee varus, 15 degrees anatomic valgus, and 10
             degrees flexion contracture

          -  Body mass index less ≤ 40 kg/m2

        Exclusion Criteria:

          -  Any brain, circulation, or heart problems that limit function

          -  Severe osteoarthritis or other orthopedic conditions that limit function in the lower
             extremity that is not undergoing the TKA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Effects of Stimulation Patterns of Deep Brain Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Parkinson's Disease (PD), Essential Tremor (ET) or Multiple Sclerosis
             (MS)

          -  Scheduled to undergo Deep Brain Stimulation (DBS) electrode implant or implanted pulse
             generator (IPG) replacement surgery

          -  Neurologically stable

          -  Able to understand the study and consent form

        Exclusion Criteria:

          -  Inability to execute the motor tasks during the study

          -  Inability to tolerate withholding anti-parkinsonian and/or anti-tremor medications

          -  Clinically ineffective DBS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Physiological Data in the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, non-pregnant women aged 20-40 years (healthy volunteers)

          -  Regular cycling (28 days +/- 2)

          -  Non-hormonal contraception methods used

          -  German-speaking

          -  Written informed consent to participate in the study

        Exclusion Criteria:

          -  Any health-related issues that may affect menstrual cycle

          -  Any consumption of medication or other substances that may affect the menstrual cycle
             or any of the physiological parameters investigated

          -  Frequent travel between time zones

          -  Sleeping disorders
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Determinants of COVID-19 Pneumonia (MC-19)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of pneumonia; Covid-19 test negative; hospitalized subjects; both sexes;
             given informed consent

        Exclusion Criteria:

          -  age lower than 18 years; pregnancy; breast-feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effect of Transcutaneous Electrostimulation (TENS) on Pain and Physical Function in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Men and women of at least 18 years of age

          -  Clinical or radiological diagnosis of knee OA according to the criteria of the
             American College of Rheumatology

          -  Knee pain lasting for six months or longer

          -  Radiographic evidence of at least one osteophyte at the tibiofemoral joint
             (Kellgren-Lawrence grade ≥ 2) or one or more of the following signs and symptoms in
             the knee; restricted range of motion, pain in motion, crepitations, morning stiffness

          -  Written informed consent

        Exclusion Criteria

          -  Patients diagnosed with rheumatoid arthritis or other musculoskeletal diseases
             affecting lower extremities

          -  Relevant effusion in the index knee

          -  Known current or remittent cancer

          -  Carry cardiac pacemaker or defibrillator in situ

          -  Knee surgery in previous 6 months

          -  Received treatment with arthrocentesis

          -  Intra-articular injection of steroids in previous 3 months

          -  Inability to understand instructions or to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction