Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Reduction of Sperm DNA Fragmentation by Oral Ginger

Eligibility criteria:
Inclusion Criteria:

          -  men with idiopathic infertility or unexplained

        Exclusion Criteria:

          -  history of varicocele, genitourinary inflammation or infection

          -  history of cigarette smoking.
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effect of Platelet-rich Plasma in Patients With Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          1. Age 18 to 65 years

          2. Body mass index (BMI) ≤33 kg/m2

          3. Grade 2And above imaging of osteoarthritis

          4. History of knee pain or swelling should have at least 4 months

        Exclusion Criteria:

          1. treated with steroids and Anti-coagulant or anti-platelet aggregation

          2. history of infectious, systemic diseases, Immune deficiency and coagulation disorders

          3. Patients with Hb ≤11, Plt ≤ 150000

          4. Varus > 10 , valgus > 10
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Visual and Auditory Breathing-swallowing Coordinated Training

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with written informed consent to participate in the study

        Exclusion Criteria:

          -  Subjects with an apparent swallowing disorder

          -  Subjects with clinically evident cerebrovascular diseases
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-007)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate to severe dry eye syndrome with or without Sjogren's syndrome or
             other autoimmune disease

        Exclusion Criteria:

          -  Intraocular or refractive surgery in the study eye within 3 months prior to study
             start

          -  Unwilling to discontinue use of contact lenses during the run-in and duration of the
             study

          -  Pregnancy or lactation
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Open Label Arimidex in Gynecomastia

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent/assent (as per local requirements), males aged 11-18 yrs.
             (after his 10th and prior to 19th birthday), gynecomastia, one breast measuring ≥ 2 cm
             in diameter (by ultrasound or caliper measurement) that has not decreased during the
             prior 3 month period by medical history and has been present for 12 months or less
             (date of onset based on best estimate of treating physician after discussion with
             patient and or patient's parent/guardian), normal renal liver and thyroid function, no
             evidence of hormone producing tumor, no evidence of hypogonadism or androgen
             resistance.

        Exclusion Criteria:

          -  Patients who have been given medications known to cause gynecomastia within the
             previous 6 months, involvement in the planning and conduct of the study (includes AZ
             staff and investigative site staff), previous enrollment in the present study,
             investigators opinion patient would be unable to comply with study protocol.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 11 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Sensenbrenner Clinical Study

Eligibility criteria:
Inclusion Criteria:

          -  Boys and girls.

          -  Aged 3 to 18 years old.

          -  Subjects with a Sensenbrenner's syndrome diagnosis and followed from 2005

          -  Parents/ legal guardian must provide non opposition prior to participation in the
             study

        Exclusion Criteria:

          -  Patients whose parents / legal guardian have object to using the data usually
             collected for care
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 13 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of the COVIDSeq Test in Nasal Swab and Saliva From a COVID-19 Asymptomatic Population

Eligibility criteria:
Subject Inclusion Criteria:

        An individual must meet the criteria below to be eligible.

          -  Individual is attending or invited to visit a participating collection site.

          -  Individual is 18 years or older at the time of consent.

          -  Individual is feeling well at the time of consent or specimen collection and does not
             have any of the following symptoms of COVID-19 per the current CDC guidance such as
             cough, shortness of breath or difficulty breathing, fatigue, fever or chills, muscle
             or body aches, headache, sore throat, new loss of taste or smell, congestion or runny
             nose, nausea or vomiting, or diarrhea.

          -  Individual is willing to participate in study procedures and able to provide written
             informed consent in the English language.

        Subject Exclusion Criteria:

        An individual cannot meet the below criteria.

          -  Individual is confirmed to have COVID-19 and continues to require isolation in
             accordance with current CDC guidelines at the time of consent or specimen collection.

          -  Individual is asymptomatic but suspected to have COVID-19 due to recent close contact
             (as currently defined by the CDC) with a person with COVID-19 and continues to require
             quarantine in accordance with current CDC guidelines at the time of consent or
             specimen collection. [5]

          -  Individual had symptoms of COVID-19 less than 10 days before time of consent or
             specimen collection."
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: BAY94-9027 PK Study Comparing to Another Long Acting Product

Eligibility criteria:
Inclusion Criteria:

          -  Males, age 18 to 65 years.

          -  Subjects with Severe Hemophilia A with a documented plasma FVIII level of < 1%

          -  ≥ 150 exposure days with FVIII concentrate(s) as supported by medical records

        Exclusion Criteria:

          -  Evidence of current or past inhibitor antibody:

          -  History of any congenital or acquired coagulation disorders other than hemophilia A.

          -  Platelet count <75,000/mm*3.

          -  Abnormal renal function (serum creatinine >2 x the upper limit of the normal range).

          -  Active liver disease verified by medical history or persistently elevated alanine
             aminotransferase or aspartate aminotransferase >5 x the upper limit of the normal
             range or severe liver disease as evidenced by, but not limited to any of the
             following: International Normalized Ratio >1.4, hypoalbuminemia, portal vein
             hypertension including presence of otherwise unexplained splenomegaly and history of
             esophageal varices.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: The Swedish Essential Tremor (SWEET) Trial

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of ET, as decided by the movement disorder specialist; Substantial
             incapacity; Duration of symptoms > 5 years; Age 18 - 75; unsatisfying effect from
             β-blockers, or be unable to tolerate the medical therapy.

        Exclusion Criteria:

          -  Cognitive impairment; Co-morbidity or non-compliance likely to jeopardize the result
             or to confuse the evaluation; Normal surgical exclusion criteria.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects.

Eligibility criteria:
Inclusion Criteria:

          -  BMI between ≥18 kg/m² and <30 kg/m² at time of screening

          -  Body weight between ≥45 kg and <100 kg

          -  Baseline vWF:Ag between ≥60% and <170% (0.6-1.7 IU/mL)

        Exclusion Criteria:

          -  History of and/or any sign or symptom indicating current abnormal hemostasis or blood
             dyscrasia, including but not limited to thrombocytopenia, thrombocytopathy,
             thromboasthenia, hemophilia, von Willebrand's disease, vascular purpura, bleeding gums
             and/or frequent nose bleeding, easy/spontaneous bruises, meno- or metrorrhagia,
             history of gastrointestinal bleeding or excessive bleeding after minor injury such as
             shaving.

          -  Family history of congenital vascular malformation (e.g., Marfan's Syndrome) and/or
             bleeding disorder (e.g., hemophilia, von Willebrand's disease, Christmas disease)

          -  Any surgical intervention (including tooth extraction) or trauma within the 4 weeks
             preceding screening for the study or any planned surgical intervention during the
             participation in the study

          -  Treatment with vitamin K, direct oral anticoagulant (DOAC), warfarin, high dose
             heparin within 2 weeks before screening
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction