Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: MTZ Plus AMX in the Treatment of Smokers and Non-smokers

Eligibility criteria:
Inclusion Criteria:

          -  Chronic periodontitis (AAP 1999);

          -  ≥35 years of age;

          -  Presence of at least 15 teeth;

          -  Minimum of 6 teeth with at least one site each with PD and clinical attachment level
             (CAL) ≥5 mm;

          -  At least 30% of the sites with PD and CAL ≥4 mm and bleeding on probing (BOP).

          -  Smokers: had smoked at least 10 cigarettes per day for a minimum of 5 years;

          -  Non-smokers: had never smoked.

        Exclusion Criteria:

          -  Previous subgingival periodontal therapy;

          -  Pregnancy;

          -  Nursing;

          -  Systemic diseases that could affect the progression of periodontal disease (e.g.
             diabetes, osteoporosis);

          -  Long-term administration of anti - inflammatory medications;

          -  Need for antibiotic pre-medication for routine dental therapy;

          -  Continuous use of mouthrinses containing antimicrobials;

          -  Antibiotic therapy in the previous 6 months

          -  Allergy to MTZ or AMX.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Testis Needle Aspiration of Sperm in Men With Azoospermia

Eligibility criteria:
Inclusion Criteria:

          -  Men with Obstructive/Non-Obstructive Azoospermia who turned to sperm cell aspiration
             for IVF and were found suitable for TEFNA and signed consent form.

        Exclusion Criteria:

          -  healthy, non-azoospermic men

          -  men who are unsuitable for the TEFNA procedure

          -  men who don't sign the Informed Consent
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  Clinically and Histologically proven painful Bullous/erosive or atrophic forms of OLP

        Exclusion Criteria:

          -  lichenoid lesions

          -  Presence of systemic conditions

          -  Smoking

          -  Known hypersensitivity or severe adverse effects to the treatment drugs or to any
             ingredient of their preparation

          -  Pregnancy or breast-feeding

          -  History of previous treatments potentially effective on OLP in last 3 months

          -  Loss of pliability or flexibility in the tissues involved by the oral lesions of
             lichen planus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: EndogenousTestosterone Response to a Testosterone Boosting Supplement

Eligibility criteria:
Inclusion Criteria:

          -  Adult male aged 20 to 40 years.

          -  Fluent in English.

        Exclusion Criteria:

          -  Currently receiving hormonal therapy or testosterone boosting supplement.

          -  Has received hormonal therapy or testosterone boosting supplement within 3 months
             prior to study.

          -  Has experienced adverse event following previous exposure to testosterone boosting
             supplements.
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Comparison Between Steroid and Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia

Eligibility criteria:
Inclusion Criteria:

          -  spontaneous local pain over lateral epicondyle of the affected elbow for more than six
             months and failure to respond to previous physical therapy or oral medications,

          -  local tenderness around the lateral epicondyle, and

          -  pain elicited or aggravated by resisted contraction of the wrist or middle finger
             extensors.

        Exclusion Criteria:

          -  local steroid injection within the past six months,

          -  coexisting elbow arthritis or arthralgia,

          -  previous trauma or surgery history over the lateral epicondyle,

          -  pregnancy or lactation, and

          -  other systemic, neuromuscular or bleeding disorders that are contraindicated to Botox
             injection.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia

Eligibility criteria:
Inclusion Criteria:

        - Azoospermia

        Exclusion Criteria:

        - Absent or surgical removed testes
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Joint Loading vs Normal Physiotherapy Care in Degenerative Knees (V1)

Eligibility criteria:
Inclusion Criteria:

          1. Patients referred to the Leeds Community Healthcare Musculoskeletal service aged 45
             years or over with primary symptoms suggestive of degenerative intraarticular knee
             pain with a dominant mechanical presentation (i.e. activity related pain, functional
             limitation, morning stiffness not exceeding 30 minutes) AND

          2. Limitation in weightbearing range of motion of the knee joint (tibiofemoral joint
             limitation in flexion or extension)

        Exclusion Criteria:

          1. Subjects with cognitive impairment or medical conditions preventing understanding or
             participation in the study

          2. Subjects with symptoms requiring surgical evaluation or other intervention

          3. Knee symptoms related to pathology other than degenerative intraarticular pathology

          4. Subjects who are contraindicated from kneeling or crouching

          5. Subjects unable to attend the full study programme
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Major Inclusion Criteria:

               -  Have completed a Corcept-sponsored study of relacorilant in endogenous Cushing
                  syndrome with at least 80% compliance with the dosing schedule.

               -  According to the Investigator's opinion will benefit from continuing treatment
                  with relacorilant

        Exclusion Criteria:

          -  Major Exclusion Criteria:

               -  Premature discontinuation from a relacorilant parent study.

               -  Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism

               -  Has poorly controlled hypertension

               -  Has Stage ≥ 4 renal failure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction