Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Prospective Hospital Registry of Patients With Suspected or Confirmed Coronavirus Infection (COVID-19) and Community-acquired Pneumonia

Eligibility criteria:
Inclusion Criteria:

          1. Patients hospitalized to the National Medical and Surgical Center named after
             N.I.Pirogov of the Ministry of Health of Russia (NMSC) with suspected or confirmed
             COVID-19 or community-acquired pneumonia.

          2. Age 18 years and older.

          3. Permanent residency in Russia.

        Exclusion Criteria:

          1. Permanent residency outside of Russia.

          2. The patient's refusal to participate in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Global Epidemiologic Study of Preexisting Immunity to AAV in Adults With Severe Hemophilia

Eligibility criteria:
Inclusion Criteria:

          1. Participant is male between 18 and 75 years old at the time of screening.

          2. Established severe hemophilia A (plasma Factor VIII (FVIII) activity <1%) or B (plasma
             Factor IX (FIX) activity ≤2%).

          3. Provision of signed informed consent form (ICF).

          4. Participant is willing and able to comply with the requirements of the protocol.

        Exclusion Criteria:

          1. Bleeding disorder(s) other than hemophilia A or B.

          2. Personal laboratory evidence of having developed inhibitors to FVIII or FIX protein at
             any time (≥0.6 Bethesda Units [BU] on any single test).

          3. Currently receiving systemic immunosuppressive therapy, cytotoxic chemotherapy,
             immunoglobulin therapy, or monoclonal antibody therapy.

          4. Received systemic antiviral and/or interferon therapy within 30 days of blood draw,
             with the exception of treatment for human immunodeficiency virus (HIV).

          5. Currently receiving ribavirin and/or interferon based therapy for active hepatitis C
             virus (HCV).

          6. Received immunoglobulin therapy or plasma infusion within 120 days of the blood draw.

          7. Has a known immune deficiency other than HIV.

          8. Has lymphocyte or plasma cell malignancies.

          9. Participant is a family member or employee of the investigator.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of chronic adrenal insufficiency

          -  Written informed consent/assent in compliance with applicable country-specific and
             local regulations

        Exclusion Criteria:

          -  Participation in an interventional clinical trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Extended Half-Life (EHL) Clotting Factor for Improving the Musculoskeletal Health of Patients With Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A

          -  Patients over 18 years

          -  Patients under prophylactic treatment with rFVIIIFc concentrates.

        Exclusion Criteria:

          -  Patients with neurological or cognitive disorders preventing the understanding of the
             various measuring instruments

          -  Patients who are scheduled for major orthopedic surgery (total arthroplasty)

          -  Not signed the Informed Consent Document
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Group Eczema Education Visits:Impact on Patient and Family Quality of Life

Eligibility criteria:
Inclusion Criteria:

          -  Children ages 2 months though 6 years.

          -  Participants must carry a diagnosis of atopic dermatitis according to the Hanifin and
             Rajka criteria.

          -  New patients or consultations at an OHSU clinic.

          -  English-speaking families will be included in this study

        Exclusion Criteria:

          -  Subjects who have been on systemic therapies for treatment of their atopic dermatitis
             (prednisone or cyclosporine)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Months old.
Subject must be at most 6 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Vitamin Gum Pharmacokinetics

Eligibility criteria:
Inclusion Criteria:

          1. Men or women aged 18 - 60 yrs old in generally good health.

          2. Healthy oral cavity with no pre-existing oral diseases including cancer,
             periodontitis, or mucositis.

          3. No chewing or swallowing disorders.

          4. No known clotting disorders.

          5. Willingness to follow the investigator instructions and requirements of the protocol.

          6. Ability to give consent.

          7. Proficiency with the English language (both written and verbal)

        Exclusion Criteria:

          1. Pre-existing oral diseases including oral cancer, periodontitis, or mucositis.

          2. Chewing or swallowing disorder.

          3. Iron deficiency or anemia. The level of deficiency needed for exclusion will be at the
             discretion of the CRC physician associated with the study.

          4. Pregnant, lactating, or planning to become pregnant during the study.

          5. Phenylketonuric

          6. Medical, social, or economic circumstance which is likely to prevent adherence to the
             protocol.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Preventing Early Child Marriage in Nepal

Eligibility criteria:
Inclusion Criteria for Clusters

          -  marginalized communities based on CARE Nepal formula

          -  communities prioritized by Nepal Government

          -  no concurrent non-governmental organization (NGO) programming

          -  no concurrent CARE programming

        Inclusion Criteria for Boys and Girls (invited to participate in the intervention, survey,
        in-depth interviews, focus group discussions)

          -  unmarried

          -  age 12 -under 17

          -  living in study community

          -  no plans to migrate in subsequent 24 months

        Inclusion Criteria for Mothers and Fathers of Selected Boys and Girls (invited to
        intervention and focus group discussions)

          -  male and female parental figures of an adolescent who has been recruited to
             participate in the intervention and associated measurement

        Exclusion Criteria for Mothers and Fathers of Selected Boys and Girls:

          -  none

        Inclusion Criteria for Community Adults:

          -  at least 25 years of age

          -  living in one of the study Communities

          -  no plans to migrate during the next two years

        Exclusion Criteria for Community Adults:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Steady State Vestibular Evoked Myogenic Potentials

Eligibility criteria:
Inclusion criteria: age between 18 and 35 years and auditory threshold less than or equal
        to 20 dBHL, between 0.5 and 8 kHz, with inter-ear frequency difference less than or equal
        to 10 dB.

        Exclusion criteria were: exposure to occupational or leisure noise; otological surgery;
        more than three ear infections within the last year; use of ototoxic medication; buzzing in
        the ear, vertigo, dizziness or other cochlear-vestibular symptoms ; presence of systemic
        alterations that could contribute to cochlear-vestibular pathologies, such as diabetes,
        hypertension, dyslipidemias and/or hormonal alterations.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: GAS-Hem Feasibility Study

Eligibility criteria:
Inclusion Criteria:

          1. Participant has a documented diagnosis of hemophilia A

          2. Participant has documented clotting factor levels of 5% or less

          3. Participant is on a prescribed regimen of continuous prophylaxis. Continuous
             prophylaxis is defined by the World Federation of Hemophilia as "… the intent of
             treating for 52 weeks a year and receiving a minimum of an a priori defined frequency
             of infusions for at least 45 weeks (85%) of the year under consideration"

          4. Participant is willing and able to comply with the requirements of the protocol

          5. Participant is proficient in the English language to allow for use of the Standardized
             Goal Attainment Scaling menu for Hemophilia (GAS-Hem) tool.

        Exclusion Criteria:

          1. Participants with an active Factor VIII (FVIII) inhibitory antibody (≥ 0.4 Bethesda
             units (BU) using the Nijmegen modification of the Bethesda assay or ≥ 0.6 BU using the
             Bethesda assay) at any time prior to screening

          2. Participant has been diagnosed with an inherited or acquired hemostatic defect other
             than hemophilia A (eg, qualitative platelet defect or von Willebrand's disease)

          3. Participant has participated in a clinical study involving a medicinal product or
             device within 30 days prior to enrollment or is scheduled to participate in a clinical
             study involving a medical product or device during the course of this study

          4. Participant is a family member or employee of the investigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Vitamin D Homeostasis in Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

          -  Stable medical condition defined as no hospitalization or emergency room visit in the
             previous 3 months

          -  No evidence of active pulmonary or systemic infection

          -  No other active inflammatory disease,

          -  No active malignancy.

          -  Normal serum ionized calcium level

        Exclusion Criteria:

          -  Hospitalization or emergency room visit in the previous 3 months

          -  Evidence of active pulmonary or systemic infection

          -  Evidence of active other inflammatory disease

          -  Evidence of active malignancy

          -  Elevated serum ionized calcium level
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment