Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Dose-Response, Safety and Efficacy of Febuxostat in Subjects With Gout

Eligibility criteria:
Inclusion Criteria:

          -  Hyperuricemia (serum uric acid ≥8.0 mg/dL).

          -  Must meet American College of Rheumatology criteria for gout.

          -  Must have adequate renal function (serum creatinine <1.5 mg/dL).

          -  Females of childbearing potential who are sexually active must agree to use adequate
             contraception, and can neither be pregnant nor lactating from Screening throughout the
             duration of the study.

        Exclusion Criteria:

          -  History of xanthinuria

          -  Alcohol consumption >14/week

          -  Has a history of significant concomitant illness.

          -  Has active liver disease.

          -  Has a body mass index greater than 50 kilogram per meter² (kg/m²)

          -  Any other significant medical condition that would interfere with the treatment,
             safety or compliance with the protocol, as defined by the investigator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients ages 18-100 who have been diagnosed with essential tremor of
             the voice (EVT) Diagnosis Code 478.75 Laryngeal Spasm.

        Exclusion Criteria:

          -  WCMC subjects under age 18

          -  Pregnant patients

          -  Patients with laryngeal pathology besides tremor, including but not limited to polyps
             and other benign lesions, precancerous or cancerous changes, vocal fold paralysis, or
             other laryngeal disorders of mobility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Efficacy and Safety of Growth Hormone Treatment in Juvenile Idiopathic Arthritis

Eligibility criteria:
Inclusion Criteria:

          -  Polyarticular or systemic juvenile idiopathic arthritis,

          -  Growth velocity below the 25th percentile and or short stature ,

          -  Treatment with glucocorticoids for at least the previous 6 months before inclusion,

          -  Prepubertal stage,

          -  Bone age below 10 in girls and 12 in boys,

          -  Growth hormone levels after stimulation with clonidine or arginine above 10 ng/ml

        Exclusion Criteria:

          -  Previous treatment with growth hormone,

          -  Endocrinopathy,

          -  Additional chronic disease beside juvenile idiopathic arthritis,

          -  Malignant disase,

          -  Chromosomal aberration or othe syndromal disease,

          -  Previous treatment with Oxandrolone,

          -  Small for gestational age,

          -  Elevated fasting glucose level
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Treatment of Vitamin D Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  Vitamin D insufficiency, defined as a serum 25(OH)D 16 to 25 ng/mL by high performance
             liquid chromotography assay

          -  Women ≥ 5 years past the date of last menses or bilateral oophorectomy, or ≥ 60 years
             old if they had prior hysterectomy without bilateral oophorectomy

          -  Total dietary and supplemental calcium intake < 600 mg daily but ≤ 1,400 mg daily,
             based on a food frequency questionnaire

        Exclusion Criteria:

          -  Women > 75 years old

          -  Hypercalcemia (serum calcium corrected for albumin > 10.4 mg/dL)

          -  Nephrolithiasis by medical record or patient report

          -  Inflammatory bowel disease, malabsorption or chronic diarrhea

          -  Stage 3, 4 or 5 Chronic Kidney Disease based on the Modification of Renal Diet (MDRD)
             formula

          -  Use of bone-active medications within the past 6 months including bisphosphonates,
             estrogen compounds, calcitonin, teriparatide, oral corticosteroids and anticonvulsants

          -  Allergy or intolerance to orange juice

          -  Allergy or intolerance to sunscreen

          -  Prior adult clinical fragility fracture of the hip, spine or wrist or a T-score below
             -2.5 at the lumbar spine or femur
Female
Accepts Healthy Volunteers

Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Program for Caregivers Involved With Mental Health Services

Eligibility criteria:
Inclusion Criteria:

          -  receive psychiatric services through the adult or young adult treatment team at the
             West Haven Mental Health Clinic

          -  have a child receiving psychiatric services through the child treatment team at the
             West Haven Mental Health Clinic

          -  express interest in receiving a parent intervention at the West Haven Mental Health
             Clinic

        Exclusion Criteria:

          -  severe mental health problems (e.g., suicidal, homicidal, psychosis, thought disorder)

          -  severely cognitively impaired

          -  have psychiatric or substance-related symptoms requiring inpatient hospitalization or
             ambulatory detoxification

          -  are not fluent in English

          -  child has a serious illness or significant developmental delay (e.g., cognitive,
             language, or motor)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: The Effect of Partial Bladder Filling on Post-operative Time to Void in Minimally Invasive Gynecologic Procedures

Eligibility criteria:
Inclusion Criteria:

          1. Hysterectomy or myomectomy planned for a benign gynecologic reason. (This means that
             there is no evidence of, or concern for, malignancy in the cervix, uterus, tubes or
             ovaries. Benign gynecologic reasons to have a hysterectomy include fibroids, abnormal
             uterine bleeding, endometriosis, and pelvic pain. Benign reason for myomectomy would
             be fibroids)

          2. Patient is scheduled to have surgery with one of the minimally invasive gynecologic
             surgeons at George Washington University Hospital (GWUH)

          3. Patient is planned for a robotic assisted total laparoscopic hysterectomy (RA-TLH) or
             a total laparoscopic hysterectomy (TLH) or robotic assisted or laparoscopic
             myomectomy.

          4. Patient is capable of informed consent.

          5. The patient has no baseline urinary disease.

        Exclusion Criteria:

          1. Hysterectomy or myomectomy is indicated for malignancy

          2. Hysterectomy or myomectomy is not being performed via robotic or laparoscopic method

          3. Patient is not capable of providing informed consent

          4. Patient has urinary disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Safety, Efficacy and Operability of Using the New Tissue Containment System During Laprascopic Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Pre- and Peri-menopausal woman patient age 18-65 years

          -  Women with fibroids, adenomyosis, and endometrial hyperplasia and indication for
             laparoscopic hysterectomy.

          -  Normal Pap smear result within one year

          -  The uterus is larger than 12 weeks of gestation

          -  The body mass index of the patients is 18.5-27.9kg/m2

          -  Signed informed consent form

        Exclusion Criteria:

          -  Women with Known or suspected malignancy

          -  patients during pregnancy and lactation

          -  Known blood diseases, bleeding coagulation disease, any part of the active bleeding or
             bleeding tendency of the constitution of the patient

          -  Patients with known severe liver and kidney dysfunction;Liver function (ALT, AST) ≥ 2
             times of normal upper limit, or renal function (Cr) ≥ normal upper limit

          -  Patients who are known to have participated in any other clinical trial within 3
             months

          -  Patients who cannot sign informed consent

          -  Patients with acute stage infection of the reproductive system or other sites
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Registry of Patients With Von WilLEbrand Disease Treated With Voncento®

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from constitutional von Willebrand disease for whom Desmopressin
             treatment is deemed ineffective or contraindicated

          -  Patients suffering from von Willebrand disease and being treated or having been
             treated with Voncento® for the treatment of surgical and non-surgical bleeding
             episodes, the prophylaxis of surgical and non-surgical bleedings

          -  Patients with no history or suspicion of inhibitors (judged on previous efficacy)

        Exclusion Criteria:

          -  Refusal of the patient or the patient's legal representative to take part in the
             study;

          -  Existence of a contraindication to the use of Voncento® treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Dietary Advice on Prescription in Kungsbacka

Eligibility criteria:
Inclusion Criteria:

          -  BMI 28-35

        Exclusion Criteria:

          -  Severe disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction