Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) regular menstrual
        cycles of 24-35 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥8.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  (1) uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus); (2)
             intrauterine adhesions（moderate - severe）, endometriosis, adenomyosis, untreated
             hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm
             and/or endometrial pressure) (3) history of adverse pregnancy (including spontaneous
             abortion, stillbirth, and fetal malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Response of Children With Atopic Dermatitis (Eczema) to Eucrisa

Eligibility criteria:
Inclusion Criteria:

          -  AD diagnosis by dermatologist or allergist based on Hanifin and Rajka criteria

          -  5% or more treatable body surface area involvement

          -  baseline Investigator's Static Assessment (ISGA) score of mild (2) or moderate (3)

          -  patient on stable regimens (consistent use 14 days before day 1 of enrollment) of
             inhaled corticosteroids and antihistamines

          -  must have lesional skin in the antecubital fossa

        Exclusion Criteria:

          -  use of topical corticosteroid, calcineurin inhibitor, or PDE4 inhibitor within 14 days
             of enrollment

          -  significant active infection

          -  any previous use of biologic therapy

          -  no pruritus at baseline visit, or other pruritic condition

          -  washing/moisturizer use 24 hours prior to tape strip biomarker collection at site

          -  uncontrolled asthma, uncontrolled allergic rhinitis, or other sleep disturbing
             condition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Mutation Exploration in Non-acquired, Genetic Disorders and Its Impact on Health Economy and Life Quality

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis: Suspicion of genetic disease. (Only one of the following criteria is
             required.) [1.1] Family member(s) with similar phenotype OR [1.2] At least two
             affected organ systems OR [1.3] One affected organ system that is known to be
             associated with multiple disease causing genes (e.g. long QT syndrome) OR [1.4]
             Multiple birth defects

          2. Both parents must be available for blood draw in order to confirm phase (segregation
             analysis) or in order to perform WGS of the trio at a later time point.

          3. Age: from birth up until age 18 years

          4. Gender: Both sexes will be included

        Exclusion Criteria:

          1. Suspicion that the phenotype is due to an acquired disease

          2. Missing informed consent from both parents or from all legal guardians for genetic
             testing in the setting of a clinical trial.

          3. Clinical diagnosis of a disease with a known monogenic cause, e.g. Phenylketonuria or
             Cystic fibrosis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men

Eligibility criteria:
Inclusion Criteria:

          -  Eligible couples are those undergoing ICSI due to azoospermia with testicular biopsy
             positive for sperm (either fresh or cryopreserved) following testicular sperm
             extraction (TESE) or aspiration (TESA).

        Exclusion Criteria:

          -  Cases with female factor infertility or woman age above 35 years will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Internet-delivered Group Counseling for Chronic Tinnitus

Eligibility criteria:
Inclusion Criteria:

          -  Patients with subjective, chronic tinnitus

        Exclusion Criteria:

          -  Enrollment in other tinnitus treatments simultaneously at the time of the intervention
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c

Eligibility criteria:
Inclusion Criteria:

          -  18-50 years old

          -  at least one intact and effusion-free middle ear

        Exclusion Criteria:

          -  bilateral otitis media

          -  unable to remain relaxed and quiet for up to 2 hours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: ESPRIT Study in Hypogonadal Men

Eligibility criteria:
Inclusion Criteria

          1. Male patients >= 18 years of age

          2. Hypogonadism not previously treated with testosterone

          3. Testosterone deficiency confirmed clinically and biochemically

          4. Being prescribed AndroGel® 1% in accordance with the local summary of product
             characteristics

        Exclusion Criteria

          1. According to the contra-indications,

          2. Unwilling or unable to sign informed consent form
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Symptom Assessment for GERD Patients Receiving H. Pylori Eradication

Eligibility criteria:
Inclusion Criteria:

          1. Patients with typical reflux symptoms (heartburn and/or acid regurgitation) validated
             by standard questionnaire GerdQ.16

          2. Aged from 18 to 70 years old.

          3. Willing to receive H. pylori eradication therapy.

        Exclusion Criteria:

          1. Symptomatic reflux patients with high grade erosive esophagitis ( Los Angeles
             classification Grade C and D) or Barrett's esophagus documented by endoscopy.

          2. Symptomatic reflux patients with a history of using PPI in recent one month.

          3. Subjects with known allergy to PPI.

          4. Peptic ulcer disease

          5. Cancers of the esophagus, stomach, and duodenum

          6. Esophageal or gastric varices

          7. Active upper gastrointestinal bleeding within 7 days prior to enrollment

          8. Status after total or subtotal gastrectomy

          9. Pregnancy

         10. Use of anticoagulants or antiplatelets within one week prior to enrollment

         11. Subjects with bleeding tendency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Open Label Study To Assess The Effectiveness Of Amlodipine-Atorvastatin Combination In Hypertension And Dyslipidemia.

Eligibility criteria:
Inclusion Criteria:

          -  Treated or untreated subjects with concurrent hypertension and dyslipidemia with BP
             and LDL-C not at target according to governing guidelines

        Exclusion Criteria:

          -  High liver enzymes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia A

Eligibility criteria:
Key Inclusion Criteria:

          -  Severe hemophilia A defined as <1 IU/dL (<1%) endogenous FVIII

          -  Male <12 years of age and weight ≥13 kg

          -  History of at least 50 documented prior exposure days to FVIII

          -  No current, or history of, inhibitor development to FVIII

        Key Exclusion Criteria:

          -  Other coagulation disorders in addition to Hemophilia A

          -  History of anaphylaxis associated with any FVIII or IV immunoglobulin administration

        NOTE: Other protocol-defined Inclusion/Exclusion criteria may apply.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 11 Years

Eligibility (NLI label): Contradiction