Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Comparison of Intra-articular and Intra-tendinous Injections for Treatment of Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of lateral epicondylitis based on 2 or more of the following
             diagnostic criteria: tenderness over the lateral epicondyle; pain with resisted wrist
             extension; pain with resisted long finger extension.

          -  Symptoms lasting a minimum of 6 weeks

          -  Pain score of >= 3/10 using the Visual Analog Scale (VAS)

          -  Age >= 18 years

        Exclusion Criteria:

          -  History of prior elbow surgery

          -  History elbow fracture within the past year

          -  Elbow instability on physical examination

          -  Elbow arthritis on radiographs

          -  Compressive neuropathy in the affected extremity (i.e.carpal tunnel, cubital tunnel)

          -  Evidence of cervical myelopathy, radiculopathy or brachial plexopathy

          -  History of systemic inflammatory condition (i.e. rheumatoid arthritis or systemic
             lupus erythematosus)

          -  Allergy to study administered medications (steroid or lidocaine)

          -  Neoplasm

          -  Non-English speaking patients

          -  Inability to comply with study protocols and follow up.

          -  Pregnant female
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effect of Functional Lumbar Stabilization Exercises in Women With Menstrual Low Back Pain

Eligibility criteria:
Inclusion Criteria:

          -  Having low back pain LBP during menstrual phase (days 1-6) of the menstrual cycle.

          -  Suffering from low back pain during all menstrual cycles in the year before the study.

          -  No back pain or low back paiun at times other than the menstrual phase.

          -  Pain intensity during menstrual LBP greater than 5 in Numeric Pain Scale

        Exclusion Criteria:

          -  History of spinal surgery, spinal or pelvic fracture and hospitalization for severe
             trauma or car accident, urinary tract infection, vaginal infection and known
             neurological disorders.

          -  Pain intensity lesser than 5 in Numeric Pain Scale
Female
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  Previously diagnosed (e.g. more than 6 months ago) primary adrenal insufficiency with
             a stable daily glucocorticoid substitution dose for at least 3 months prior to study
             entry

          -  Signed informed consent to participate in the study.

        Exclusion Criteria:

          -  Clinical or laboratory signs of significant cerebral, cardiovascular, respiratory,
             Hepatobiliary, pancreatic disease

          -  Clinically significant renal dysfunction

          -  Clinical or laboratory signs of significant gastrointestinal emptying or motility
             disease

          -  Any medication with agents which could interfere with hydrocortisone kinetics

          -  Pregnant or lactating women

          -  Regular dehydroepiandrosterone (DHEA) medication for the past 4 weeks

          -  Oral oestrogen medication for the past 4 weeks

          -  Deranged mineralocorticoid status
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The C3I COVID-19 Project

Eligibility criteria:
Inclusion Criteria:

          -  COVID-19 positive PCR test

          -  a COVID-19 ICD-10-CM diagnosis code during a healthcare visit, or a COVID-19 positive
             antibody test

          -  Must be a patient in one of the 21 participating healthcare systems

        Exclusion Criteria:

          -  N/A
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from severe and disabling ET with serious impact on their quality
             of life (QoL).

          -  18-70 years old

          -  Free of evolutive and untreated psychiatric disorder

          -  Tremor must be predominant in the upper limbs although it can affect the lower limbs,
             head and voice.

          -  Affiliation to a social security system

          -  Written informed consent signed by the participant and the investigator (prior to any
             examination required by research)

        Exclusion Criteria:

          -  Parkinsonian tremor

          -  Pregnancy or lactating women

          -  Severe co-morbidity (cardiac, renal or respiratory failures, evolutive cancer)

          -  Impaired cognitive functions (score <130 on Mattis scale).

          -  Patients with severe atrophy or lesions on MRI

          -  Depression (Beck > 10)

          -  Participation in another clinical research for 18 months (after surgery)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing

Eligibility criteria:
Inclusion Criteria:

          -  A consecutive series of patients with symptoms suggestive of GERD were enrolled from
             the Gastroenterology outpatient clinic in our institution. The typical GERD symptom
             was defined as heartburn and/or acid regurgitation of at least three episodes per week
             for a minimum of three months.

        Exclusion Criteria:

          -  Patients who received concurrent PPI treatment, had a medical contraindication to
             rabeprazole therapy, reported a history of peptic ulcer disease or gastrointestinal
             surgery, peptic ulcer disease or malignancy proven by endoscopy, the presence of alarm
             features (e.g., dysphagia, weight loss, bleeding, abdominal mass, and/or anemia), or
             who were unwilling or unable to provide informed consent were excluded from the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Impact of Cognitive Behavioral Therapy on Parasomnias

Eligibility criteria:
Inclusion Criteria:

          -  DSM 5 Parasomnia Disorder

          -  at least one parasomnia event per week

          -  daytime fatigue or sleepiness

          -  6 months in duration

        Exclusion Criteria:

          -  current use of agents known to triggers parasomnias such as Lithium carbonate,
             Thioridazine, Chlorpromazine, Perhphenazine, Methaqualone, or Amitriptyline,

          -  for participants taking benzodiazepines or Prazosin, a stable dose regime for the past
             4 weeks,

          -  excessive alcohol consumption defined as the consumption of > 10 alcoholic beverages
             per week
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Dementia Early Recognition and Response in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  Patients with memory or other cognitive impairments suggestive of dementia syndrome

          -  those with a formal diagnosis of dementia, of any type.

        Exclusion Criteria:

          -  Patients and carers who are already involved in concurrent research

          -  If the key professional feels that an approach to the person with dementia or their
             carer would be inappropriate, for example the dementia is very severe, or that an
             approach may increase distress

          -  and any other important reason that the key professional may have for why the person
             with dementia or their carer should not be contacted.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD

Eligibility criteria:
Inclusion Criteria:

          -  persistent or recurrent symptoms despite continuous medical treatment, at least one
             typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at
             least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste),
             pathologic esophageal acid exposure as documented by a reflux-related DeMeester score
             ≥14.7, and symptom correlation ≥50%, and/or reflux episodes >73.

        Exclusion Criteria:

          -  any distinct hiatal hernia detectable by gastroscopy or barium radiography, dysphagia,
             esophageal strictures, poor physical status (American Society of Anesthesiologists
             (ASA) scores III and IV) and pregnancy.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: GnRh Antagonist Protocol With Delayed Start Stimulation in Patients With Poor Ovarian Response

Eligibility criteria:
Inclusion Criteria:

          -  a history of ovarian surgery;

          -  previous treatment using conventional protocols that yielded less than three oocytes;

          -  antral follicle count of less than 5 on menstrual cycle day 2-3; and basal serum FSH
             concentration between 10 and 19 IU/l.

        Exclusion Criteria:

          -  ovarian failure including basal FSH above 20 IU/l or no antral follicle by ultrasound
             examination;

          -  Endometriosis grade 3 or higher;

          -  Any contraindications to ovarian stimulation treatment.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction