Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Prevention of Severe Covid-19 in Infected Elderly by Early Administration of Convalescent Plasma With High-titers of Antibody Against SARS-CoV2

Eligibility criteria:
Inclusion Criteria:

        - Age ≥ 75 or age 65-74 with at least 1 of the following comorbidities: arterial
        hypertension, diabetes, obesity, chronic obstructive pulmonary disease, heart disease,
        chronic kidney disease

          -  Last 48 hours: (A)Axillary temperature ≥ 37.5oC or febrile equivalent, combined with
             (a) dry cough and/or (b) breathing difficulty and/or (c) odinophagia and/or (d)
             anosmia/dysgeusia and/or (e) any of the following symptoms: fatigue, anorexia,
             myalgias or rhinorrhea.

          -  Confirmed diagnosis SARS-Cov2 by RT-PCR

          -  Give Informed consent

        Exclusion Criteria:

          -  Severe respiratory disease

          -  Cardiac insufficiency,

          -  Chronic renal failure,

          -  Primary hypogammaglobulinemias,

          -  Myelodysplastic syndromes,

          -  Chronic linfoproliferative syndromes,

          -  Monoclonal gammapathies,

          -  Known hypersensitibility,

          -  Active cancer,

          -  HIV, HBV or HCV infection,

          -  Chronic administration of immunosuppressants,

          -  Body transplant history,

          -  Chronic liver disease, Chronic lung disease with oxygen requirement.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Male or female aged 40 to 85 years with a clinical diagnosis of OA of the target knee
             according to the American College of Rheumatology (ACR) criteria, including:

          -  Symptoms for at least 6 months prior to screening, AND

          -  Knee pain in the target knee for 30 days of the preceding month (periarticular knee
             pain due to OA and not due to other conditions such as bursitis, tendonitis, etc.) AND

          -  The pain in the target knee required the use of nonsteroidal anti-inflammatory drugs
             (NSAIDs) either over the counter (OTC) per recommendation of a physician or
             prescribed.

        Exclusion Criteria:

          -  Body mass index (BMI) > 40

          -  Any subject who disobeyed the restriction of prohibited therapies (i.e., use rescue
             medication) during Screening Washout Period.

          -  Secondary OA of the knee (rheumatoid arthritis, gout, psoriasis, syphilitic
             neuropathy, ochronosis, metabolic or other primary bone disease or acute trauma).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Autophagy and Pathological Aging

Eligibility criteria:
Inclusion Criteria:

        Inclusion criteria for both groups:

          -  Women > 65 y: 2 groups

        Inclusion criteria for Osteoporosis group (Alzheimer and non-Alzheimer):

          -  Osteoporotic femoral neck fracture requiring hip remplacement and fullfilling WHO
             definition of osteoporosis. Without any cognitive impairment for the first subgroup
             (MMSE > 26 and normal IADL) and with a final diagnosis of alzheimer disease in the
             other subgroup (DSM-IV-TR)

        Inclusion criteria for Control group:

          -  Non osteoporotic (no fragility fracture (clinical or on VFA) and bone mineral density
             T-score > 2.5 SD at all sites)

          -  No cognitive impairment (MMSE > 26 and normal IADL)

        Exclusion Criteria:

        Non-Inclusion Criteria for both groups:

          -  Other pathologies associated with autophagy: Parkinson's disease, Crohn's disease,
             cancers, myopathies, type 2 diabetes

          -  Méd Medications interfering with autophagy: current corticosteroids, parathyroid
             hormone, estrogen, chloroquine, hydroxychloroquine, lithium, metformin,
             bisphosphonates,

          -  Dementia of non-Alzheimer type
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: The Effectiveness of Smart Health Management Program for Patients With Chronic Illness

Eligibility criteria:
Inclusion Criteria:

          -  Subject 19 years old and more

          -  Subject who understands the purpose of the study and signs with informed consent form

          -  Subject with chronic disease (hypertension, diabetes, dyslipidemia)

          -  Subject with more than one Poor Disease Control Indicator

               1. HbA1C 7.0% or more

               2. Systolic BP 140mmHg or more

               3. LDL-cholesterol 130mg/dL or more

          -  Subjects who use smart phones and PCs (those who can use ICT-based health care
             programs)

        Exclusion Criteria:

          -  Inability to speak, understand, or write Korean

          -  Inability to understand the contents of the provided materials due to poor eyesight
             and hearing

          -  Medical conditions that would limit adherence to participation of the clinical trial
             (as confirmed by their referring physician; e.g. dyspnea, severe depression and other
             mental disorders)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Update in VWD Laboratory Diagnosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients referred for VWD diagnosis or previously diagnosed with VWD

        Exclusion Criteria:

          -  Patients with other bleeding disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation

Eligibility criteria:
Inclusion Criteria:

          -  Diarrhea

          -  constipation

        Exclusion Criteria:

          -  Shock

          -  Sepsis

          -  Past history with GI tract surgery

          -  Immunodeficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Months old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Ecological Momentary Assessment of Eating Behavior in Overweight Youth

Eligibility criteria:
Inclusion Criteria:

        Participants be included if they are overweight or obese (BMI≥85th %ile) and aged 8-14
        years.

        Exclusion Criteria:

        Participants will be excluded if they 1) are currently taking any medications known to
        affect weight or appetite (e.g., antidepressants, steroids, chemotherapy drugs); 2) have a
        current or past diagnosis of an eating disorder involving purging or suppressed body weight
        (e.g., bulimia nervosa or anorexia nervosa); 3) are unable to read and understand English
        fluently; or 4) are receiving concurrent treatment for obesity.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Pulsed Electromagnetic Field Treatment for Painful Periods

Eligibility criteria:
Inclusion Criteria:

          -  Female with persistent (>3months) cyclical period pain associated with menstruation
             (defined as 5 or more on VAS).

          -  Able to give written, Informed consent

          -  Able to wear device and keep up-to-date records of use

          -  Agrees to attend follow up

          -  If currently using hormonal contraception agrees to continue on the same dose for the
             duration of the trial.

        Exclusion Criteria:

          -  Age under 16 years.

          -  Trying to conceive or <6 weeks post partum

          -  Currently participating or planning to participate in another clinical trial
Female
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Metformin in Overweight Type 2 Diabetes Mellitus

Eligibility criteria:
Inclusion Criteria:

          -  Type 2 Diabetes Mellitus

          -  BMI more than 25

        Exclusion Criteria:

          -  Type 1 diabetes

          -  pancreatic diabetes

          -  presence of concomitant endocrinal disorder

          -  non-overweight type 2 diabetes

          -  type 2 diabetes with secondary failure to sulfonylurea and taking insulin

          -  presence of proliferative retinopathy or chronic renal failure

          -  known cirrhosis of liver

          -  heavy alcoholic

          -  presence of active tuberculosis

          -  known HIV disease or any active infection

          -  major mental illness

          -  failure to comply with the exercise advice due to physical incapacity (e.g., severe
             osteoarthritis, hemiparesis or any other disabling neurological disease)

          -  present pregnancy (or planning pregnancy)

          -  lactating mothers

          -  using any kind of hormones including oral contraceptives, systemic corticosteroids,
             nicotinic acid

          -  use of anti-obesity drug within the past 3 months

          -  chronic gastroparesis or chronic severe gastrointestinal symptoms

          -  a history of gastric or duodenal ulcers

          -  abdominal surgery within 1 year will not be included in the study

          -  patients with congestive heart failure or overt nephropathy will also not be included,
             due to unreliability of anthropometric measurements in such subjects and the relative
             risk of lactic acidosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families

Eligibility criteria:
Inclusion Criteria:

          1. Participant must be a person with DMD who is 11 years or older or The parent/legal
             guardian of a person with DMD who is under the age of 18 years.

          2. Confirmed diagnosis of DMD with written proof of disease provided

          3. Resident of the U.S.

          4. Able to read, write and communicate in English

          5. Able to grant informed consent

          6. Willing to participate in a 45 minute telephone interview

          7. Ability to view or receive a document from the interviewer before or during the
             interview (web browser, ability to receive a text, fax or document by mail)

        Exclusion Criteria:

        1. Inability to meet any of the inclusion criteria
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 11 Years old.


Eligibility (NLI label): Contradiction