Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Clinical Decision Support System Based on Non-invasive Tele-monitoring of COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of SARS-CoV-2 disease, detected by PCR or antigen test, performed
             72 h prior to patient inclusion in the study.

          -  Acceptance to sign the informed consent document.

          -  Possession of a Smartphone or Tablet with Internet connection.

          -  Possession of mental faculties to participate in the study.

        Exclusion Criteria:

          -  Age below the age of health majority (16 years).

          -  Lack of digital skills to use the Home App.

          -  Cognitive impairment that prevents the patient from participating in the study.

          -  Disabling pathology of the upper limb.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Adults and teenagers with untreated, spontaneous active Cushing's syndrome

          -  Diagnosis verified at the University of Michigan Medical Center, including the
             following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol
             secretion rate, and plasma cortisol level

          -  Lack of normal circadian cortisol secretion and failure to suppress following 2 mg of
             dexamethasone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Evaluation of Patients With Known or Suspected Heart Disease

Eligibility criteria:
-  INCLUSION CRITERIA:

        The following is a representative list of the types of patient presentations and potential
        diagnoses eligible for this protocol:

          1. Coronary artery disease with angina or inducible myocardial ischemia as determined by
             noninvasive testing.

          2. Cardiomyopathies including congestive phenotypes.

          3. Peripheral artery disease with intermittent claudication or limb-threatening ischemia.

          4. Renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or
             evidence of ischemic nephropathy.

          5. Upper extremity peripheral artery disease.

          6. Diabetes with heart failure.

          7. Pulmonary hypertension.

        EXCLUSION CRITERIA:

        Pregnancy, for those patients who require catheterization-based diagnostics.

        Inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Deep braIn Stimulation for Tremor TractographIC Versus Traditional

Eligibility criteria:
Inclusion Criteria:

          1. Male or female patients aged ≥ 25 and ≤ 80 years

          2. Patients with Essential Tremor according to the criteria of the consensus statement of
             the movement disorders society (Deuschl et al. 1998) are included with a medical
             treatment resistant and disabling postural and/or intentional tremor.

          3. FTMTRS to be completed within 42 days prior surgery

          4. Stable tremor medication for at least 3 months prior inclusion

          5. Written informed consent

        Exclusion Criteria:

          1. Major Depression with suicidal thoughts or suicidal thoughts in history

          2. Dementia (Mattis Dementia Rating Score ≤ 130)

          3. Acute psychosis

          4. Patient incapability

          5. Nursing care at home

          6. Surgical contraindications

          7. Medications that are likely to cause interactions in the opinion of the investigator

          8. Known or persistent abuse of medication, drugs or alcohol

          9. Persons who are in a relationship of dependence/employment with the sponsor or the
             investigator

         10. Fertile women not using adequate contraceptive methods: female condoms, diaphragm or
             coil, each used in combination with spermicides; intra-uterine device; hormonal
             contraception in combination with a mechanical method of contraception;

         11. Current or planned pregnancy, nursing period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Physical Activities by Technology Help (PATH)

Eligibility criteria:
Inclusion Criteria:

          -  A cancer survivor of breast, prostate, lung, colorectal, cervical or oral cancer
             survivor and live within the Baltimore Maryland area.

          -  Finished your active cancer treatment at least three months ago.

          -  Overweight or obese and do not exercise daily.

          -  Do not have any physical limitation to do mild to moderate physical activities.

          -  Have a smart phone (iPhone or Android device) with Wi-Fi internet connection at home.

          -  Actively using an email account

          -  Willing to accept the random study assignment.

          -  Willing to wear a Fitbit band 'a physical activity tracking device' on your wrist for
             five weeks every single day.

          -  Willing to have an Echo speaker 'a smart home speaker with voice assistant' installed
             in your home and use the digital voice assist for four weeks.

          -  Willing to receive daily text messages on your phone for four weeks.

          -  Willing to provide us with access to your Fitbit physical activities data.

          -  Willing to sign the consent form.

        Exclusion Criteria:

          -  Already doing moderate to high physical activities in their daily life (rapid
             screener).

          -  Planning to relocate within the next 4-5 weeks.

          -  Stage 4 cancer.

          -  Already using physical activity tracker or part of a physical activity program.

          -  Part of another study that may interfere with our outcome of interest, unstable mental
             condition.

          -  Mental condition that prevents patient from performing the study activities and
             requirements.

          -  Pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Texture Analysis for Postmenopausal Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  The study will enroll 40 postmenopausal women with a T score < -2 either at the lumbar
             spine or the femoral neck: 20 who decide to begin anti-resorptive therapy (treated
             group), and 20 women who decline such therapy (control group). We will attempt to
             match the patients and the controls for T score (within 0.3) and age (within 5 years).

          -  All study participants will be:

               -  at least 3 years past the last menstrual period,

               -  not on HRT, Raloxifene or calcitonin for at least 6 months.

        Exclusion Criteria:

          -  All study participants will not be on bisphosphonates during the previous 12 months.

          -  Women with secondary causes of osteoporosis will be excluded.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 59 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Investigating the Effects of Neuromobilization in Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged >18 years

          -  A symptom duration of >3 months

        Exclusion Criteria:

          -  Bilateral symptoms

          -  Rheumatologic diseases affecting the elbow and the wrist

          -  Musculoskeletal disorders due to connective tissue diseases

          -  Diffuse pain syndrome

          -  Cervical radiculopathy

          -  Nerve compression syndromes involving upper extremity

          -  Undergone surgery at the affected arm

          -  Received an LE treatment in the last 6 months

          -  An inability to perform the exercises
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effectiveness of Manual Therapy and Exercise in Shoulder OA

Eligibility criteria:
Inclusion Criteria:

          -  over 50 years of age

          -  Osteoarthritis > Grade 3 on the Kellgren-Lawrence scale

          -  Presence of at least two of the following findings:

          -  morning stiffness that resolves within 60 minutes

          -  pain > 3/10 on a numerical pain rating scale

          -  asymmetrical mobility in either contralateral elevation and/or glenohumeral rotation,
             or notable crepitus with active motion.

        Exclusion Criteria:

          -  medical co-morbidities (diabetes and rheumatoid arthritis)

          -  adhesive capsulitis

          -  fractures

          -  scapulothoracic paresis

          -  surgery in past year

          -  inability to speak English language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: COMPARISON OF LAPAROSCOPIC TOTAL EXTRAPERITONEAL HERNIA REPAIR AND LICHTENSTEIN HERNIA REPAIR

Eligibility criteria:
Inclusion Criteria:

          -  Unilateral inguinal hernia (diagnosed by physical examination or imaging)

          -  Sexual Active

          -  Male gender

          -  aged between 18 and 65

          -  ASA 1-2

          -  EHS Classification (Primary, lateral or medial, 1 and 2)

        Exclusion Criteria:

          -  Patients with previous abdominal and inguinal hernia surgery

          -  ASA 3-4

          -  Sexually inactive

          -  Emergency patients (Etrangule inguinal hernia)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Treatment of Optic Neuropathies Using Autologous Bone Marrow-Derived Stem Cells

Eligibility criteria:
Inclusion Criteria:

          -  Patient should suffer from Optic Nerve Atrophy diseases like diabetic retinopathy and
             retinal pigmentation.

          -  Age in between 18-55 years old

          -  Willingness to undergo bone marrow derived autologous cell therapy.

          -  Ability to comprehend the explained protocol

          -  Ability and willingness to regularly visit to hospital for protocol and follow up

        Exclusion Criteria:

          -  Patients with preexisting or current systemic disease such as lung, liver,
             gastrointestinal, cardiac, immunodeficiency, syphilis, or clinically relevant
             polyneuropathies.

          -  History of life threatening allergic or immune- mediated reaction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction