Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Trial to Learn What Happens to Different Medicinal Forms of BAY2328065 When They Enter the Body and How Safe They Are in Healthy Male and Female Participants

Eligibility criteria:
Inclusion Criteria:

          -  Participant must be 18 to 55 years of age inclusive, at the time of signing the
             informed consent

          -  Participants must be overtly healthy as determined by medical evaluation including
             medical history, physical examination, laboratory tests, ECG, blood pressure and heart
             rate

          -  Confirmation of the subject's health insurance coverage prior to the first screening
             examination/visit

          -  Body mass index (BMI) within the range 18 and 30 kg/m^2 (inclusive)

          -  Male participants who are sexually active and female participants of childbearing
             potential must use one of the methods of contraception described in this protocol

        Exclusion Criteria:

          -  Incompletely cured pre-existing diseases for which it can be assumed that the
             absorption, distribution, metabolism, elimination and effects of the study
             intervention will not be normal

          -  Relevant diseases within the last 4 weeks prior to start of the first study
             intervention

          -  Known severe allergies, non-allergic drug reactions, or multiple drug allergies

          -  Existing chronic diseases as specified in protocol

          -  Regular use of therapeutic or recreational drugs

          -  Suspicion of drug or alcohol abuse

          -  Smoking equal or more than 10 cigarettes/day

          -  History of COVID-19; contact with SARS-CoV-2 positive persons or COVID-19 patients
             within the last 4 weeks prior admission to the ward or positive SARS-CoV-2 viral RNA
             test
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment