Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema of Rosacea

Eligibility criteria:
Key Inclusion Criteria:

          1. Male or female who is at least 18 years of age or older.

          2. A clinical diagnosis of facial rosacea.

          3. A Clinician Erythema Assessment (CEA) score of greater than or equal to 3 at Screening
             and at Baseline/Day 1 (prior to the study drug application).

          4. A Patient Self Assessment (PSA) score of greater than or equal to 3 at Screening and
             at Baseline/Day 1 (prior to the study drug application).

        Key Exclusion Criteria:

          1. More than 20 facial inflammatory lesions of rosacea

          2. Particular forms of rosacea (rosacea conglobata, rosacea fulminans, isolated
             rhinophyma, isolated pustulosis of the chin) or other concomitant facial dermatoses
             that are similar to rosacea such as peri-oral dermatitis, demodicidosis, facial
             keratosis pilaris, seborrheic dermatitis, acute lupus erythematosus, or actinic
             telangiectasia.

          3. Current treatment with monoamine oxidase (MAO) inhibitors, barbiturates, opiates,
             sedatives, systemic anesthetics, or alpha agonists.

          4. Less than 3 months stable dose treatment with tricyclic anti depressants, cardiac
             glycosides, beta blockers or other antihypertensive agents.

          5. Current diagnosis of Raynaud's syndrome, thromboangiitis obliterans, orthostatic
             hypotension, severe cardiovascular disease, cerebral or coronary insufficiency, renal
             or hepatic impairment, scleroderma, Sjögren's syndrome, or depression.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Corneal Nerve Structure in Sjogren's

Eligibility criteria:
Inclusion Criteria:

          -  Suspected or confirmed Sjogren's syndrome

          -  18+ years of age

        Exclusion Criteria:

          -  Any condition that in the opinion of the investigator may confound study results or
             cause concerns for safety
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Boys aged 8 to 18 years with DMD/BMD confirmed genetically or by muscle biopsy

          -  Informed consent

        Exclusion Criteria:

          -  Other clinically significant concomitant disease states (e.g., renal failure)

          -  Inability to follow the procedures of the study, e.g. due to language problems,
             psychological disorders, dementia, etc. of the participant or his/her parents or legal
             caregivers,

          -  Inability to lie still for the duration of the imaging procedures (approximately 45
             minutes each for echocardiography and CMR)

          -  MR-incompatible implanted or accidentally incorporated metal device or claustrophobia
             that prohibits use of magnetic resonance imaging
Male
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Single Dose Study in Subjects With Severe Hemophilia A Comparing Pharmacokinetic Parameters for BAY81-8973 and Advate

Eligibility criteria:
Inclusion Criteria:

          -  Males, age 18 to 65 years

               -  Subjects with Severe hemophilia A with a documented plasma FVIII level of <1%

               -  ≥ 150 exposure days with FVIII concentrate(s) as supported by medical records

        Exclusion Criteria:

          -  Evidence of current or past inhibitor antibody

               -  History of any congenital or acquired coagulation disorders other than hemophilia
                  A

               -  Platelet count <75,000/mm3

               -  Abnormal renal function (serum creatinine >2 times the upper limit of the normal
                  [ULN] range)

               -  Active liver disease verified by medical history or persistently elevated alanine
                  aminotransferase (ALT) or aspartate aminotransferase (AST) >5 times the ULN or
                  severe liver disease as evidenced by, but not limited to any of the following:
                  International Normalized Ratio (INR) >1.4, hypoalbuminemia, portal vein
                  hypertension including presence of otherwise unexplained splenomegaly and history
                  of esophageal varices.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Biological Clock Dysfunction in Optic Nerve Hypoplasia

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of ONH (Diagnosis will be confirmed by ocular fundus
             photography.Disc-macula distance 0.35 or below. In eyes without ONH, the DD/DM ratio
             is greater than 0.3581.)

          -  Ages 2-10 years

          -  Ability to ambulate independently

          -  Under care of endocrinologist if on pituitary hormone replacement therapy.

        Exclusion Criteria:

          -  Non-ambulatory

          -  Active malignancy

          -  Cardio-respiratory disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effectiveness of a Walking Intervention on Impact Loading and Pain

Eligibility criteria:
Inclusion Criteria:

        Subjects with a clinical definition of knee OA using NICE guidelines:

          -  Age ≥ 45

          -  Walking related joint pain in the last week that averages ≥ 4 on 11-point numeric
             rating scale, where 0 = no pain and 10 = worst pain possible

          -  History of knee pain for at least 3 months

          -  Morning stiffness in the morning lasting less than 30 minutes

        Exclusion Criteria:

          -  Walk with an assistive device

          -  Current use of oral opiates or centrally acting pain medications

          -  History of lower extremity surgery

          -  Underwent an intra-articular knee joint injection in the past 3 months

          -  Suffer from inflammatory arthritis or other conditions that affect lower extremity
             functions

          -  Currently receiving treatment for their knee and unwilling to stop this treatment for
             the duration of the study

          -  Currently pregnant

          -  Skin allergies to adhesives
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a diagnosis of probable, laboratory-supported probable, or definite
             amyotrophic lateral sclerosis according to the El Escorial revised criteria

          -  Disease duration ≤ 24 months

          -  Disease progression in the past 3 months

          -  Score ≥ 2 at the item "swallowing" of the ALS Functional Rating Scale Revised

          -  Score ≥ 2 at the item "walking" of the ALS Functional Rating Scale Revised

          -  Treatment with steady regimen of riluzole for a minimum of 1 month before study entry,
             and desiring its continuation

          -  Able to give informed consent

          -  Written informed consent

        Exclusion Criteria:

          -  Motor neuron diseases other than ALS

          -  Severe head trauma in the past

          -  History of seizures

          -  History of ischemic stroke or hemorrhage

          -  Pacemaker

          -  Metal implants in the head/neck region

          -  Severe comorbidity

          -  Intake of illegal drugs

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Low Level Laser Therapy in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Both males and females

          -  Patients with age 45-65 years

          -  Patients with knee OA of grade II or III according to Kellgren-Lawrence grade.

          -  Pain intensity ranging between> 5 measured by Numeric Pain Rating Scale.

          -  Patients who had minimum score of 25 on the Western Ontario McMaster Universities
             Osteoarthritis Index (WOMAC) total score.

          -  Patients having knee pain for at least 3 months.

        Exclusion Criteria:

          -  Patients with pain in other lower limb joints.

          -  Patients with symptomatic hip osteoarthritis.

          -  Patients with knee surgery in last 6 months.

          -  Patients with complaint of cancer, diabetes, neurological deficit or uncontrolled
             hypertension
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Cross Checking to Reduce Adverse Events in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  All patients that visit the ED during one of the two periods of recruitment, monday to
             friday between 8:30am and 4:30pm, will be screened for inclusion. We chose this time
             interval as they correspond to period that can be exposed to a cross checking, which
             will occur at 11:30 am, 2:00 pm and 4:30 pm.

        Exclusion Criteria:

          -  Patients whose care is not provided by an EP (for example psychiatrist or
             maxillo-facial surgeon)

          -  Scheduled return attendance to the ED

          -  Low severity, defined by

               1. Triage level 5 on a 1 to 5 scale 13,14

               2. Patients referred to a "minor" or "fast track" unit

               3. Patients discharged home less than 1 hours after first contact with an EP
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Talc Outpatient Pleurodesis With Indwelling Catheter

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than or equal to 18 years old

          -  Diagnosis of a paramalignant pleural effusion (defined as a recurrent pleural effusion
             directly caused by malignancy with known thoracic involvement)

          -  Estimated life expectancy greater than 3 months

          -  Full lung re-expansion on chest x-ray after thoracentesis

        Exclusion Criteria:

          -  Age less than 18 years old

          -  Pregnant or lactating subject

          -  Any history of prior pleural talc administration

          -  History of an indwelling pleural catheter placed on the side of the active
             paramalignant pleural effusion

          -  Estimated life expectancy less than 3 months

          -  Active clinical heart failure

          -  Inability to return for frequent follow up appointments

          -  Current incarceration
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment