Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: NBI for Identifying Resection Margin Status in Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  The patient from over 20 to under 90 years

          -  The patient who is diagnosed as gastric cancer clinically by endoscopy or computed
             tomography

          -  The patient who is informed and consent about the purpose and contents of this study
             prior to the participation in this study

        Exclusion Criteria:

          -  The patient who shows far advanced gastric cancer preoperatively or intraoperatively

          -  The patient with previous medical history of other treatment for gastric caner such as
             endoscopic resection, chemotherapy, radiation, immunotherapy, and so on
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury.

Eligibility criteria:
Inclusion Criteria:

          -  Patients of both sexes, of any race, aged over 12 years.

          -  Ability to read, understand and sign the IC, in the case of minors consent of
             responsible;

          -  Clinical diagnosis of bruises, sprains, trauma, muscle damage occurred in less than 24
             hours or muscle pain, myofascial pain or tendinitis.

          -  Patients able to understand and maintain the clinical protocol.

        Exclusion Criteria:

          -  Known hypersensitivity to components of the formulas of both the drug test as the
             comparator.

          -  Known hypersensitivity to paracetamol.

          -  Location of the lesion with skin wound or irritated.

          -  Liver or kidney disease known.

          -  Pregnant or lactating women.

          -  Patients who require surgery or immobilization.

          -  Patients with fractures or rupture of the ligaments.

          -  Patients using anticoagulants.

          -  Patients with severe concomitant systemic diseases, such as cancer, diabetes, or
             acquired heart disease, hematological diseases, seizure disorders, autoimmune
             diseases, renal failure, severe infections, hormonal disorders and pulmonary
             disorders.

          -  History of alcoholism or illicit drug use;

          -  Use of NSAIDs, corticosteroids or venoterápicos, topics or any other form of
             administration.

          -  Conditions in the opinion of the researcher make the patient unsuitable to participate
             in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Survey in Patients With Chronic Adrenal Insufficiency in Germany

Eligibility criteria:
Inclusion Criteria:

          -  age > 18 years

          -  chronic adrenal failure with disease duration > 12 months and hormone replacement
             therapy for cortisol deficiency

        Exclusion Criteria:

          -  adrenal insufficiency due to adrenocortical carcinoma

          -  AI due to long-term pharmacological glucocorticoid treatment

          -  glucocortiocid doses above 7.5 mg prednisolone equivalent for other reasons than AI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates

Eligibility criteria:
Inclusion Criteria:

          -  Healthy term, gestational age of 38-42 weeks inclusive.

          -  Able to be transported to the Eye Clinic.

          -  No longer monitored. On no intravenous or other lines.

        Exclusion Criteria:

          -  History of hyperglycemia in the infant (a blood sugar greater than 100mg%, per
             Laboratory Policy on Critical Values for infants less than 20 days old).

          -  Feeding intolerance.

          -  Green-tinged aspirates/emesis.

          -  Abdominal distention.

          -  History of genetic consult indicating any abnormality.

          -  Any known ocular disorder.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 38 Weeks old.
Subject must be at most 42 Weeks

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic lesions.

          -  OLP lesions with the diagnosis confirmed both clinically and histopathologically.

          -  Clinical score higher than 3.

          -  Disease duration of more than 2 months.

          -  Absence of dysplasia in histological section

        Exclusion Criteria:

          -  Presence of any visible oral lesion other than OLP.

          -  Pregnant or breast-feeding women,

          -  Immuno-deficiency diseases.

          -  Current malignancy or malignancy in history.

          -  Concomitant treatment potentially effective on OLP within the previous 2 months such
             as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs.

          -  Severe or recurrent infections.

          -  Lichenoid reaction.

          -  Patients presents with skin lesions which may require systemic corticosteroid therapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: NSAID Treatment in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Patients eligible for the study were:

          -  older than 50 years and

          -  had primary knee OA diagnosed according to the clinical and radiological criteria of
             the American Rheumatism Association.

        Further inclusion criteria were:

          -  clinical signs of joint inflammation (warmth, swelling or effusion) and

          -  a disease severity grade 2 or 3 according to the Kellgren-Lawrence classification

        Exclusion Criteria:

          -  allergy to NSAIDs,

          -  progressive serious medical conditions (such as cancer, AIDS or end-stage renal
             disease),

          -  history of gastrointestinal ulcer or bleeding,

          -  a hemoglobin concentration lower than 11.5 g/dL,

          -  renal diseases (serum creatinine concentration more than 1.2 times the upper limit of
             the normal range according to the central laboratory definition reference values), or

          -  liver dysfunction (serum alanine or aspartate transaminase concentrations more than
             1.5 times the upper limit of normal range according to the central laboratory
             definition reference values).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Admission to the general cardiology or heart failure services and under the care of a
             cardiologist at the study institution

          -  New York Heart Association Class II-IV heart failure

          -  Ejection fraction < 40%

          -  Serum hemoglobin < 12.0 g/dL

          -  Ferritin < 100 ng/mL or 100-300 ng/mL with transferrin saturation (TSAT) < 20%

          -  Patients deemed by an attending physician to require intravenous iron therapy based on
             previous attempts to correct iron deficiency or other patient-specific circumstances

        Exclusion Criteria:

          -  Anemia of other known etiology (e.g., malignancy, malabsorption syndromes)

          -  Use of iron or erythropoietin-stimulating agents within previous 12 weeks

          -  Blood transfusion within previous 12 weeks; additionally, if patients receive blood
             transfusions during the study period, they will remain in the safety analysis but will
             be excluded from efficacy analysis

          -  Active bleeding

          -  Known infection at admission

          -  Immunosuppressant therapy

          -  Renal replacement therapy

          -  Known pregnancy

          -  Any other criteria deemed by the attending physician to warrant exclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Low Dose Continuous Administration of the Progesterone Receptor Modulator VA2914

Eligibility criteria:
Inclusion Criteria:

          -  women in good general health with regular, ovulatory menstrual cycles

          -  age 18-35

          -  not pregnant

          -  not sexually active or reliably use barrier methods of contraception

          -  normal liver and renal functions and normal laboratory exams

        Exclusion Criteria:

          -  pregnant or breastfeeding

          -  oral contraception, IUD or other hormonal treatment

          -  use of agents known to induce hepatic P450

          -  cardiovascular disorder

          -  hepatic, renal, or gastrointestinal disorder

          -  metrorrhagia

          -  abnormal transvaginal ultrasound (at baseline)

          -  history of abnormal endometrial biopsy,

          -  cancer

          -  depression

          -  mental illness

          -  epilepsy

          -  migraines

          -  abnormal Pap Smear requiring further exploratory examination

          -  anovulatory cycle before treatment

          -  extreme overweight or underweight (body mass index < 16 ou >28)

          -  subjects unlikely to comply with the protocol, e.g., uncooperative attitude, inability
             to return for follow-up visits, and unlikelihood of completing the study

          -  use of narcotics

          -  more than 10 cigarettes per day, more than 2 glasses of wine/beer per day

          -  surgical procedures planned in the 6 months following screening visit
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Neuroelectrical Biomarkers for Alzheimer's Disease Stages

Eligibility criteria:
Inclusion Criteria:

          -  Age: 70-85 years old

          -  Presence of memory impairment

          -  Completed educational level: middle school

          -  Visual and auditory acuity: normal or corrected-to-normal

        Exclusion Criteria:

          -  Monogenic AD

          -  Presence of a neurological disorder

          -  Stroke that has occurred in the last three months

          -  Prohibited medications

          -  Residence in skilled nursing facility

          -  Illiteracy, is unable to count or to read

          -  Claustrophobia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 70 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment