Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Haemochromatosis and Periodontitis

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 35 to 64 years with homozygosity hemochromatosis C282Y

          -  Patients regularly enrolled in a health insurance plan

          -  Patients with at least 10 natural teeth

          -  Patients who have given informed written, dated and signed consent

        Exclusion Criteria:

          -  Diabetic patients

          -  Simultaneous participation in another study

          -  Pregnant or lactating women

          -  The incapacitated persons and persons deprived of their liberty

          -  Patients who do not speak French, both written and spoken

          -  Patients previously included in this trial

          -  Patients with heart valves or endovascular equipment (risk of infective endocarditis
             ...)

          -  Patients with a history of maxillofacial surgery

          -  Patients whose oral status is considered incompatible with entry into the study, at
             the discretion of the investigator

          -  Patients on drugs that can cause gingival hypertrophy, such as Hydantoins (phenytoin),
             Dihydropyridines, Diltiazem or Ciclosporin

          -  Patients on medication that can cause gingival bleeding (anticoagulants, antiplatelet
             agents and aspirin).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Changes in Iron Markers Following Iron Loading in Hemodialysis Patients

Eligibility criteria:
Inclusion Criteria:

          -  hemodialysis for three months minimum

          -  stable epoetin dose for two months minimum

          -  serum ferritin concentration < 1000 ng/ml

          -  transferrin saturation < 50%

          -  parathormone concentration < 800 pg/ml

        Exclusion Criteria:

          -  hemoglobin concentration > 13g/dl

          -  serum ferritin concentration < 20 ng/ml

          -  vitamin B12 and/or folic deficiency

          -  other hematologic disease than anemia

          -  cancer

          -  hypothyroidism

          -  infectious disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Modified Luteal Support for Frozen-Thawed Embryo Transfer - A Prospective Study

Eligibility criteria:
Inclusion Criteria:

          -  20-40 years old women

          -  Spontaneously ovulating women

          -  Treated in our IVF unit for frozen-thawed embryo transfer

          -  At least one top quality embryo

        Exclusion Criteria:

          -  PGD patients

          -  More than 4 previous embryo transfers
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Urinary and Sexual Functions After Subtotal Versus Total Abdominal Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          1. An age over 35 and below 50 years.

          2. Menstruating women.

          3. No symptomatic uterine prolapse. .

          4. Normal cervical smears.

          5. Benign lesions.

          6. Active sexual life.

          7. Functioning ovaries.

        Exclusion Criteria:

          1. Known endometriosis.

          2. Overt neurological or psychiatric disorder.

          3. Candidate for vaginal hysterectomy.

          4. Use of hormone replacement therapy.

          5. Oophorectomy.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Tadalafil and Sildenafil for Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of DMD confirmed by muscle biopsy or DNA analysis

          2. Age 7-15y

          3. Ambulatory

          4. No clinical evidence of heart failure

        Exclusion Criteria:

          1. Hypertension, diabetes, or heart failure by standard clinical criteria

          2. Elevated BNP level (>100 pg/ml)

          3. LVEF < 50%

          4. Wheelchair bound

          5. Cardiac rhythm disorder, specifically: rhythm other than sinus, SVT, atrial
             fibrillation, ventricular tachycardia

          6. Continuous ventilatory support

          7. Liver disease

          8. Renal impairment

          9. Contraindications to tadalafil or sildenafil (use of nitrates, alpha-blockers, CYP3A
             inhibitors, amlodipine, or other PDE5A inhibitors)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Microenvironment and Male Fertility

Eligibility criteria:
Inclusion Criteria:

          -  Men diagnosed with infertility who consent to participate in the study

        Exclusion Criteria:

          -  Prior hormone replacement therapy

          -  Antibiotic use in past 6 months

          -  Inability to consent for self, due to age or mental capacity

          -  Infertility attributable to identifiable causes other than hypogonadism
Male

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Feasibility and Benefit of Laparoscopic Hysterectomy With Less Than 3 Millimeter Diameter's Instruments in Current Practice

Eligibility criteria:
Inclusion Criteria:

          -  patient candidate for total inter-adnexal hysterectomy or for hysterectomy with
             oophorectomy and

          -  benign gynecological pathology: fibroids, adenomyosis, polyps, dysfunctional uterine
             bleeding.

        and

          -  affiliation to social security and

          -  informed consent

        Exclusion Criteria:

          -  ASA III or IV patients,

          -  age> 80 years old,

          -  history of major abdominal surgery by laparotomy

          -  severe obesity (BMI> 35kg / m2)

          -  pathology of hemostasis and coagulation (liver disease, bleeding disorders)

          -  uterine volume estimated on preoperative ultrasonography > 300 g

          -  minor patients,

          -  adult lacking legal capacity

          -  patients suffering from mental illness incompatible with informed consent, refusal to
             participate.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Longitudinal Efficacy of Dental Implants in Anterior Areas

Eligibility criteria:
Inclusion Criteria:

          -  Missing anterior teeth

        Exclusion Criteria:

          -  Pregnancy

          -  Cigarette smoking

          -  Diabetes Mellitus

          -  Other significant medical conditions or habits likely to compromise bone healing

          -  Chronic use of medications likely to compromise bone healing
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Multiple Escalating Dose Study of BAY1093884 in Adults With Hemophilia A or B With or Without Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Male severe hemophilic patients with undetectable FVIII activity <1% or FIX activity
             <2%, with or without inhibitors (any titer) are eligible.

          -  Subjects with a past history of inhibitors (any inhibitor titer) are eligible.

          -  Age ≥18 years.

          -  Documentation of ≥4 bleeding episodes (any type or location of bleeds, treated or not)
             within the 6 months prior to screening.

          -  For subjects on prophylaxis: Willingness to interrupt ongoing prophylaxis.

          -  For subjects on immune tolerance induction (ITI): Willingness to interrupt ongoing
             ITI.

        Exclusion Criteria:

          -  History of any other coagulation disorder (particularly disseminated intravascular
             coagulopathy or combined FVIII/FV deficiency) or platelet disorder.

          -  History of diseases related to venous thromboembolic events (e.g., pulmonary embolism,
             deep vein thrombosis, thrombophlebitis) or thrombotic microangiopathy.

          -  Risk factors for venous or arterial diseases (e.g., uncontrolled hypertension,
             uncontrolled diabetes).

          -  History of cardiac, coronary and/or arterial peripheral atherosclerotic disease

          -  Platelet count <100,000/μL.

          -  Human immunodeficiency virus (HIV) infection with a cluster of differentiation 4
             (CD4+) lymphocyte count of <200/mm^3
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID19 Infection

Eligibility criteria:
Inclusion Criteria:

          1. Laboratory confirmed COVID19 infection defined with a positive RT-PCR from any
             specimen.

          2. Hospital admission with at least one of the following:

               -  fever ≥ 36.6 °C from axillary site; or ≥ 37.2°C from oral site; or ≥ 37.6°C from
                  tympanic or rectal site.

               -  Respiratory rate ≥ 24 bpm

               -  cough

          3. Spontaneous breathing with or without hypoxia of any degree. Gas exchange and
             ventilation maybe assisted by any continuous continuous airway pressure (CPAP), or any
             system of Non Invasive Ventilation (NIV), with Positive End-Expiratory Pressure (PEEP)
             ≤ 10 cmH2O.

          4. ≤ 8 days since onset of the symptoms

        Exclusion Criteria:

          1. Pregnancy, or positive pregnancy test in a predose examination

          2. Open tracheostomy

          3. Therapy with high flow nasal cannula

          4. Clinical controindication, as deemed by the attending physician
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Romosozumab (AMG 785)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy males and females between 45 to 80 years of age

          -  Postmenopausal females

          -  Low bone mineral density, defined by bone mineral density (BMD) T-scores between -1.0
             and -2.5, inclusive, for the lumbar spine [L1-L4] or total evaluable vertebrae [if
             fewer than L1-L4] or total hip)

          -  25-hydroxyvitamin D ≥ 20 ng/mL

          -  Weight ≤ 98 kg (216 lb) and/or height ≤ 196 cm (77 in)

        Exclusion Criteria:

          -  Osteoporosis defined by bone mineral density (BMD) T-scores < -2.5 for the lumbar
             spine (L1-L4) or total evaluable vertebrae (if fewer than L1-L4) or total hip

          -  Diagnosed with any condition that would affect bone metabolism

          -  Previous exposure to AMG 785
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction