Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Digital Intervention for HIV Prevention in Black Adolescent Girls

Eligibility criteria:
Inclusion Criteria:

        Both phases (includes focus groups- Phase 1)

          -  Black (race)

          -  Heterosexual

          -  Currently enrolled in high school

        Pilot Test (Phase 2)

          -  Ability to participate in web-based videogame

          -  Willing to sit for at least 60 minutes (to play the game)

          -  No HIV testing in the last 12 months

          -  Ability to provide assent or parental/guardian consent

        Exclusion Criteria:

          -  Failure to meet inclusion criteria
Female
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Elastography as Gouty Arthropathy Outcome (EGO)

Eligibility criteria:
Inclusion Criteria:

          1. Subjects who are at least 18 years of age but younger than or equal to 99 years of
             age.

          2. Subjects with gouty arthritis as determined by the ACR 1977 classification criteria
             for gouty arthritis.

          3. Subjects with one palpable tophus detectable by one of the three clinical parameters
             described.

             -

        Exclusion Criteria:

          1. Subjects who are not eligible for urate lowering treatment or show a hypersensitivity
             to these drugs or class of compounds.

          2. Subjects with significant cardiovascular, neuropsychiatric, hematologic, hepatic,
             renal or endocrine dysfunction who in the opinion of the principal investigator are
             unfit for participation in a clinical trial.

          3. Subjects for which the clinical and laboratory assessment would provide undue
             discomfort and / or are contraindicated.

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Risk Stratification in Children and Adolescents With Primary Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          1. Index patients:

               -  Age ≤18 years

               -  written informed consent of parents/legal guardians

               -  diagnosis of primary cardiomypathy:

               -  DCM: left ventricular (LV) systolic dysfunction and dilatation greater than two
                  standard deviations (SD) above the mean of a normal population

               -  HCM: LV hypertrophy and septal wall thickness above two SD

               -  RCM: diastolic dysfunction and concordant atrial enlargement

               -  LVNC: separation of the myocardium into a compacted (C) and a non- compacted (NC)
                  layer with an NC/C ratio >2 in echocardiography and/or >2.3 in CMR

               -  ARVC: according to the revised Task Force Criteria

          2. First-degree family members (parents and siblings):

               -  Age ≥3 years

               -  written informed consent of parents/legal guardians and siblings ≥18 years

        Exclusion Criteria:

          -  unwillingness to give consent

          -  myocardial inflammation / myocarditis

          -  systemic disease with cardiac involvement (secondary cardiomyopathy)

          -  structural congenital heart disease
No condition on gender to be admitted to the trial.


Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: To Assess the Efficacy of CitruSlim® on Body Composition as Well as Metabolic and Hormonal Factors in Overweight and Obese Individuals

Eligibility criteria:
Inclusion Criteria:

          1. Male and female participants with the age of ≥18 and ≤ 60 years of age.

          2. BMI of ≥25 - ≤ 35 kg/m2

          3. Waist circumference:India: Men: > 94 cm (37 inches), Women: >80 cm (31.5 inches) USA:
             Men: > 102 cm (40 inches), Women: >89 cm (35 inches)

          4. Triglycerides >150 mg/dL

          5. Blood pressure: Systolic: ≥130 mm Hg and/or Diastolic: ≥85 mm Hg

          6. Fasting blood glucose ≥ 100 mg/ dl

          7. Low HDL level: Men: < 40 mg/dL, Women: < 50 mg/dL

          8. Ready to give voluntary, written, informed consent to participate in the study.

        Exclusion Criteria:

        Participants meeting any of the following criteria will be excluded from the trial:

          1. Current smoker.

          2. Inability to walk independently.

          3. Presence of unstable, acutely symptomatic, or life-limiting illness.

          4. Neurological conditions causing functional or cognitive impairments

          5. Unwillingness or inability to be randomized to one of three intervention groups.

          6. Bilateral hip replacements.

          7. Exposure to any non-registered drug product within 3 months prior to the screening
             visit.

          8. Unable/unwillingness to complete study specific diaries (digital/paper-based).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: An RSA and DEXA Study on Migration of Proximal Interphalangeal (PIP) Joint Prostheses of the Hand

Eligibility criteria:
Inclusion Criteria:

          -  Patients with osteoarthrosis of the PIP joints.

          -  Patients with sufficient bone quality for implantation of a non-cemented prosthesis.
             This is estimated by the surgeon preoperatively.

          -  Informed written patient consent.

          -  Patients must read and understand Danish.

        Exclusion Criteria:

          -  Patients with neuromuscular or vascular diseases in the affected upper extremity.

          -  Patients who, preoperatively, are found to have unsuitable bone quality for
             un-cemented arthroplasty fixation, for instance bone cysts not visible on x-ray.

          -  Patients who cannot refrain from taking non-steroidal anti-inflammatory drugs (NSAIDs)
             postoperatively including cox-2 inhibitors.

          -  Patients with previously diagnosed osteoporosis.

          -  Women who are pregnant or are at risk of getting pregnant during the time of
             investigation.

          -  Patients with rheumatoid arthritis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained infertility (UI)

        Exclusion Criteria:

          -  body mass index (BMI) ≥35 kg/m2,

          -  Follicle Stimulating Hormone >10 International Unit /Litter in early follicular phase,

          -  diagnosed cause of infertility, menstrual cycle irregularity,

          -  ovarian cysts,

          -  sever cervical stenosis,

          -  former IUI,

          -  ongoing pregnancy and

          -  renal or hepatic diseases were all the exclusion criteria.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Silicone Arthroplasty vs. Arthrodesis in the Distal Interphalangeal Joint

Eligibility criteria:
Inclusion Criteria:

          -  primary osteoarthritis in the distal interphalangeal joint

          -  require surgical treatment

          -  patient aged 18 years and over

          -  signed written informed consent

        Exclusion Criteria:

          -  posttraumatic osteoarthritis

          -  rheumatoid disease

          -  pregnant woman

          -  any disease process that would preclude accurate evaluation (e.g. neuromuscular,
             psychiatric or metabolic disorder)

          -  legal incompetence

          -  no knowledge of German
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: sCD163 in ALS Patients

Eligibility criteria:
Inclusion Criteria:

          -  ALS and controls(lumbar puncture at our department)

        Exclusion Criteria:

          -  <18 years

          -  Other CNS disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Inter-examiner Reproducibility of Clinical Examination Tests for Athletes With Longstanding Groin Pain

Eligibility criteria:
Inclusion Criteria:

          -  Male athlete (performing sports ≥ 1x/week) with sports-related groin pain ≥ 4 weeks

          -  Age: 18 - 40 years

        Exclusion Criteria:

          -  Prior assessment/treatment of one of the two examiners for the same complaint (<6
             months)

          -  Prior surgery in the hip- and groin area

          -  Clinical signs of prostatitis or urinary tract infections

          -  More than 7 days between the two examiners assessment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Effectiveness of a Transmuscular Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair

Eligibility criteria:
Inclusion criteria;

          -  Age > 18 years

          -  BMI (body mass index) 20-35

          -  ASA (American Association of Anesthesiologists Classification system for physical
             status) I-III.

          -  Scheduled for elective laparoscopic inguinal hernia operation

        Exclusion criteria:

          -  Allergy to latex, local anesthesia or opioids

          -  Chronic pain with daily opiate use

          -  Patients with severe renal and/or hepatic disease

          -  Local infection at the site of injection

          -  Systemic infection

          -  AV block 2-3

          -  Inability to understand written or spoken Norwegian

          -  Inability to cooperate

          -  Dementia

          -  Known abuse of alcohol or medication

          -  Coagulation disorder

          -  Pregnancy Previously operated with same side operation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment