Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: tDCS and Sex Differences

Eligibility criteria:
Inclusion Criteria:

          1. Has a regular menstrual cycle (for women only)

          2. Young adult (18-35 years)

          3. Right-side dominant

          4. At least 30 min of moderate-intensity, physical activity on at least 3 days of the
             week for at least the last 3 months

          5. Without chronic neurological, psychiatric, or medical conditions

          6. Not taking any psychoactive medications.

        Exclusion Criteria:

          1. Pregnant

          2. Known holes or fissures in the skull

          3. Metallic objects or implanted devices in the skull (e.g., metal plate)

          4. Women on hormonal contraceptives/supplements.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged 12 to 65 years

          -  Severe hemophilia A

          -  History of more than 150 exposure days (ED) with clotting factor concentrates

          -  Currently receiving episodic treatment with FVIII; no regular prophylaxis for more
             than 6 consecutive months in the past 5 years

          -  No current Factor VIII inhibitor or history of inhibitor

          -  Willing to use electronic patient diary

        Exclusion Criteria:

          -  Presence of another bleeding disease that is different from hemophilia A

          -  Thrombocytopenia

          -  Abnormal renal function

          -  Presence of active liver disease

          -  Known hypersensitivity to FVIII
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: International Study on Syncope of Uncertain Etiology

Eligibility criteria:
Inclusion Criteria:

          -  Suspected or certain neurally-mediated syncope, based on the Guidelines of the ESC TF
             on Syncope.

          -  3 syncope episodes in the last 2 years.

          -  Severe clinical presentation of syncope requiring treatment initiation in the
             judgement of the investigator.

          -  Age >30 years.

          -  Patients have undergone carotid sinus massage, and ILR implantation.

        Exclusion Criteria:

          -  ILR not implanted for any reason; in this case, the patients are still followed in the
             ILR-not implanted group.

          -  Carotid sinus syndrome.

          -  Suspected or certain cardiac syncope.

          -  Symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement.

          -  Loss of consciousness different from syncope (e.g. epilepsy, psychiatric, metabolic,
             drop-attack, TIA, intoxication, cataplexy).

          -  Steal syndrome.

          -  Psychologically or physically (due to any other illness) unfit for participation in
             the study according to the opinion of the investigator.

          -  Patient compliance doubtful.

          -  Patients who are geographically or otherwise inaccessible for follow-up.

          -  Patient unwilling or unable to give informed consent;

          -  Pregnancy.

          -  Life expectancy < 1 year due to non-cardiac cause
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee

Eligibility criteria:
Inclusion Criteria:

          -  male or female patients aged between 18 and 75 years

          -  everyday joint pain for the past three months

          -  global pain intensity in the involved joint (hip or knee) of "moderate" to "severe"
             within the last 48 h

        Exclusion Criteria:

          -  acute inflammation or ischaemic necrosis

          -  paget's disease, chondrocalcinosis, ochronosis of the hip/knee joint

          -  slowly progressing hip/knee arthropathy in particular of tuberculosis aetiology

          -  hip/knee arthropathy due to diabetes mellitus

          -  Charcot's joint

          -  villous synovitis

          -  chondromatosis of the synovium

          -  patients with existing gastritis or existing ulcers or bleedings in the
             gastrointestinal tract or patients with history of gastrointestinal ulcers or
             gastrointestinal haemorrhage in the past 6 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Atlas Predicted DBS Settings in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

        Seleced for DBS of the VIM nucleus at Vanderbilt Medical center Diagnosis of essential
        tremor

        Exclusion Criteria:

        Unable to use the patient handheld programmer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Six Months DHEA Treatment in Female Adrenal Failure

Eligibility criteria:
Inclusion Criteria:

          -  Female,

          -  Adrenal insuficiency,

          -  Stable and safe anticonception,

          -  Stable hydrocortison substituation treatment.

        Exclusion Criteria:

          -  Neoplastic and thromboembolic disease,

          -  Diabetes mellitus.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: A Trial of Booklet Based Self Management of Dizziness

Eligibility criteria:
Inclusion Criteria:

          -  Be 18 years or over

          -  Be registered with a participating GP

          -  Must have visited their GP for dizziness in the last 2 years

          -  Must complete the consent form, and baseline questionaire indicating they are still
             suffering from dizziness and that quick head movements make them dizzy.

        Exclusion Criteria:

          -  Non-Labyrinthe cause of dizziness identified by GP

          -  Medical contraindications from making normal head movements

          -  Serious co-morbidity

          -  Moved away from practice

          -  Recently deceased

          -  Non-English speakers, and unable to read/write in English.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Qudratus Lumborum Block Versus Unilateral Intrathecal Block for Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

        - physical status ASA: I-II BMI >18kg/m2<30kg/m2 written informed consent from the patient
        scheduled for open unilateral inguinal hernia repair

        Exclusion Criteria:

          -  uncooperative patient

          -  Allergy to local anesthetic drugs

          -  patients on chronic alcohol, opioid, tranquilizer or sedative use

          -  Pregnant females.

          -  Psychological, mental disorders, or depression.

          -  Patients receiving anticoagulants therapy or suspected coagulopathy.

          -  Patients with infection or previous surgery at sit of anesthetic procedures.

          -  Patients with significant cardiovascular, respiratory, renal, hepatic, or metabolic
             disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids

Eligibility criteria:
Inclusion Criteria:

          -  Confirmation of diagnosis of dystrophinopathy, documented by clinical exam and
             dystrophin DNA mutation analysis

          -  Ambulatory male subjects between the ages of 7-11 years

          -  Stable dosage of corticosteroids for 3 months prior to entry (Screening/Baseline Day
             0) and during treatment period

          -  Able to follow instructions and give assent

          -  Able to complete nonsedated MR

        Exclusion Criteria:

          -  Presence of metallic orthopedic hardware in the lower extremity that could affect
             MRI/MRS measurements

          -  Routine MRI exclusion criteria such as the presence of a pacemaker, cochlear implant,
             or cerebral aneurysm clip

          -  Subjects not capable of cooperating during MR examination

          -  Known hypersensitivity to L-arginine

          -  Exposure to another investigational agent, investigational supplements, growth hormone
             within 3 months prior to entry (Screening/Baseline Day 0) or during treatment period

          -  Subjects must not be taking L-arginine for at least 4 weeks prior to entry (Day 0)

          -  Subjects who are non-ambulatory or with daytime ventilatory dependence
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy

Eligibility criteria:
Inclusion Criteria:

          -  Turner syndrome by karyotype

        Exclusion Criteria:

          -  Thyroid abnormality

          -  Glucocorticoid treatment
Female
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment