Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Efficacy of Purslane in Treatment of Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  Biopsy confirmed symptomatic oral lichen planus: WHO histological criteria in
             combination with clinical appearance will be used for diagnosis

          -  Patients who had symptoms such as burning sensation, pain

          -  Patients not on any immunosuppressive or immunomodulatory treatment. In case they
             were,then such treatment should be stopped and a washout period of 1 month was given.

          -  Patients of both sexes between 30 to 70 year's old

          -  Patients who gave written informed consent

          -  Patients who were willing for evaluation in second week after therapy and every 1
             month up to 6 months

        Exclusion Criteria:

          -  The presence of histological signs of dysplasia

          -  Patients suffering from any localized or systemic disease

          -  Renal disease patients

          -  Pregnant patients

          -  Patients who can not continue the study for private or social reasons

          -  Patients who used lichenoid reaction including drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Antireflux Mucosectomy (ARMS) for Treatment of Gastroesophageal Reflux

Eligibility criteria:
Inclusion Criteria:

          1. Patients with typical symptoms of GERD with symptomatic response to PPI therapy for ≥
             3 months

          2. Hill's grade II and III of the gastroesophageal junction

          3. One of the following abnormalities in the objective assessment 3.1. Excessive acid
             exposure at the distal esophagus evidenced by 24 hour pH tests using % total time pH <
             4 and / or DeMeester score 3.2. Endoscopic evidence of LA classes A,B,C or D
             esophagitis 3.3. Defective LES assessed by HRM with resting pressure of < 6mmHg or
             total length of less than 4cm or abdominal length of less than 2cm

        Exclusion Criteria:

          1. Age > 70 yrs of < 18 yrs

          2. Pregnancy

          3. Any type of Hiatus hernia

          4. Patients with underlying malignancy

          5. ASA above grade III
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation

Eligibility criteria:
Inclusion Criteria:

          -  ALS diagnosed patients according to Airlie House criteria

          -  treated with riluzole

          -  respiratory quotient (RQ) of patients in indirect calorimetry (IC) should be in
             between 0.7 and 0.87

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Vertebroplasty In The Treatment Of Acute Fracture Trial - The VITTA Trial

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Presence of:

          -  at least one and at most two acute VCF (< 6 weeks) at levels caudate to T4, confirmed
             with physical examination and radiographic imaging

          -  if timing of the fracture is unclear, the following criteria are required for
             inclusion in the trial

               1. an MRI scan showing edema at the fracture level(s) or

               2. a bone scan showing increased uptake

          -  Physical examination showing axial back pain likely secondary to the VCF with
             restricted mobilization (score not maximum on any one of the following Barthel's Index
             items: transfer, mobility, bathing, dressing, stairs and toilet use)

          -  French or English speaking patient willing to return for follow-up or capable of
             following up with phone interviews if needed

        Exclusion Criteria:

          -  Recent (<30 days) major surgery causing debilitating pain

          -  Coagulopathy or thrombocytopenia precluding interventional treatment

          -  Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Basic Care Revisited_Communication for Patient Participation

Eligibility criteria:
Inclusion Criteria:

          -  Speaking the Dutch language

        Exclusion Criteria:

          -  No serious cognitive impairments
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The CASCADE Study - Measures of Complement Activation and Inflammation in Patients With Covid-19

Eligibility criteria:
Inclusion Criteria:

        - 1. Adults ≥18 years old requiring hospital admission for COVID-19

        2. COVID-19 confirmed by either*:

          -  A positive swab (using RT-PCR)

          -  OR based on a high level of clinical probability confirmed by the presence of typical
             symptoms and compatible radiological findings on imaging with no alternative cause for
             these findings identified by the treating physician.

        Exclusion Criteria:

          -  1. Renal replacement therapy on ITU

             2. Significant trauma (including an acute fracture or significant head injury)

             3. Massive transfusion of blood products

             4. Confirmed bacteraemia with pathogenic organism on blood cultures or other severe
             bacterial infections (including abscess/empyema) which persist despite broad-spectrum
             antibiotics and are thought to be significantly contributing to the patient's symptoms
             and clinical state. Recruitment will not be delayed however pending a negative
             culture.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Semen Analysis and Insight Into Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  infertile males

        Exclusion Criteria:

          -  suergery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Economic Impact of Four Varieties of Mesh Inguinal Hernia Repair- a Double-Blinded, Prospective, Randomized Trial

Eligibility criteria:
Inclusion Criteria:

          -  Unilateral primary inguinal hernia presenting for repair

        Exclusion Criteria:

          -  Recurrent repairs

          -  Females

          -  Bilateral repairs

          -  Repairs done with other operative procedures
Male
Accepts Healthy Volunteers
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Health-Related QoL Among Women Receiving Hysterectomy in NTUH

Eligibility criteria:
Inclusion Criteria:

        laparoscopic assisted vaginal hysterectomy leiomyoma adenomyosis-

        Exclusion Criteria:

        other types of operations other types of gynecological disease-
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Effect of Testosterone on Mood and Quality of Life

Eligibility criteria:
Inclusion Criteria:

          -  Age: 50 or older

          -  Total Testosterone <=280 ng/dl

          -  Subsyndromal depressive disorder: either dysthymia or minor depression (per DSM IV and
             DSM IV appendix)

        Exclusion Criteria:

          -  PSA >=3.0

          -  Klinefelter's syndrome

          -  Prostate or breast cancer

          -  Hospitalized in the past month

          -  Obstructive BPH

          -  Current testosterone treatment

          -  Schizophrenia, bipolar disorder, dementia

          -  Treatment with antipsychotics or benzodiazepines

          -  Alcohol dependence or other substance dependence

          -  Suicidal or psychotic symptoms
Male
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Versartis Long-Acting Growth Hormone in Children Compared to Daily rhGH

Eligibility criteria:
Inclusion Criteria:

          -  Chronological Age ≥ 3.0 years and ≤ 10.0 (girls) and ≤ 11.0 (boys).

          -  Pre-pubertal status: Absent breast development in girls, testicular volume < 4.0 mL in
             boys.

          -  Diagnosis of GHD as documented by two or more GH stimulation test results ≤ 10.0
             ng/mL.

          -  Height SD score ≤ -2.0 at screening.

          -  Weight for Stature ≥ 10th percentile.

          -  IGF-I SD score ≤ -1.0 at screening.

          -  Delayed bone age (≥ 6 months).

        Exclusion Criteria:

          -  Prior treatment with any growth promoting agent

          -  History of or concurrent significant disease (e.g. diabetes, cystic fibrosis, renal
             insufficiency).

          -  Chromosomal aneuploidy, significant gene mutations (other than those that cause GHD)
             or confirmed diagnosis of a named syndrome.

          -  A diagnosis of Attention Deficit Hyperactivity Disorder.

          -  Daily use of anti-inflammatory doses of glucocorticoid.

          -  Prior history of leukemia, lymphoma, sarcoma or cancer.

          -  Treatment with an investigational drug in the 30 days prior to screening.

          -  Known allergy to constituents of the study drug formulation.

          -  Ocular findings suggestive of increased intracranial pressure and/or retinopathy at
             screening.

          -  Significant spinal abnormalities including scoliosis, kyphosis and spina bifida
             variants.

          -  Significant abnormality in screening laboratory studies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Contradiction