Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus

Eligibility criteria:
Inclusion Criteria:

          -  right-handed subjects

          -  19-65 years of age

          -  debilitating unilaterial or bilateral tinnitus

          -  Experiencing the presence of phantom auditory preception for >6 months

          -  Tinnitus Handicap Questionnaire score of >30

        Exclusion Criteria:

          -  significant neurological disease

          -  acoustic neuromas or glomus tumors

          -  active Meniere's disease

          -  profound hearing loss

          -  non English speaking

          -  personal or family history of epilepsy

          -  personal history of head injury, aneurysm, stroke, previous cranial neurosurgery,
             neurological or psychiatric disorders, metal implants in the head or neck, a
             pacemaker, pregnancy, migraines,

          -  medications that lower seizure threshold and are contraindicated

          -  individuals who have been taking certain medications

          -  claustrophobia

          -  patients who do not exhibit significant cortical asymmetries on PET
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Three-times-weekly Versus Daily Growth Hormone (GH) Treatment in naïve GH-deficient Children

Eligibility criteria:
Inclusion Criteria:

          -  Growth hormone deficiency clinically and biochemically demonstrated

        Exclusion Criteria:

          -  Children affected by multiple pituitary hormone deficiency or receiving any other kind
             of hormonal replacement therapy or drug and GHD children with a shorter follow-up
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active Conditions

Eligibility criteria:
Inclusion Criteria:

          -  patients suffering from moderate or severe hemophilia A (FVIII <5%, ≥ 12 years old)

          -  factor treatment with ADVATE© or ADYNOVI©

          -  use of myPKFiT

        Exclusion Criteria:

          -  patients suffering from other coagulopathies

          -  participants without written consent

          -  participants < 12 years old

          -  joint surgery like arthroscopy, synovectomy up to six months before study

          -  suffering from different rheumatologic diseases like M. Bechterew, Psoriasi or other
             local or generalized joint infections (Borreliosis, septic arthritis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain)

Eligibility criteria:
Inclusion Criteria:

          1. Men and women ages 18-75.

          2. Willing to participate and sign an inform consent.

          3. Having heartburns, acid regurgitations and/or chest pain at least twice a week for at
             least 3 months.

          4. Ability to stop anti-acid and anti-pain medications for at least two weeks.

        Exclusion Criteria:

          1. History of upper gastrointestinal surgery.

          2. Concomitant diseases that may affect esophageal perception (diabetes mellitus,
             neuropathy).

          3. Concomitant medications that may affect esophageal perception (anti-inflammatory,
             anti-depressants drugs).

          4. Pregnancy.

          5. Severe conditions such as cardiac failure, renal failure and other that may be
             contraindication for upper endoscopy.

          6. Erosive esophagitis on upper endoscopy or pathological result of ambulatory 24-hour pH
             monitoring.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Percutaneous Vertebroplasty Versus Conservative Treatment of Pain

Eligibility criteria:
Inclusion Criteria:

          -  new pain in spine (within 6 months)

          -  x-ray verified low energy spinal fracture(s)

        Exclusion Criteria:

          -  less than 20% or more than 90% reduction of the vertebral height

          -  lack of pain at fracture level

          -  no need for continuous analgesic treatment

          -  patient no able to communicate

          -  general anaesthesia contraindicated

          -  MRI not possible

          -  coagulopathy (not adjustable)

          -  spondylitis

          -  discitis

          -  spinal metastasis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: ATHN 8: PUPs Matter Study

Eligibility criteria:
Inclusion Criteria:

          -  Congenital hemophilia A; FVIII </=5% or congenital hemophilia B; FIX </=5%;

          -  Birth date on or after January 1, 2010;

          -  Care established at one of the participating HTCs;

          -  Co-enrollment in the ATHNdataset; and

          -  Parent or authorized guardian can provide informed consent

        Exclusion Criteria:

          -  Patients who are referred to the HTC with no record of bleed and factor utilization
             data
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 13 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Neuromuscular Ultrasound in ALS

Eligibility criteria:
Inclusion Criteria:

          -  Subjects referred to the electromyography laboratory for ALS.

        Exclusion Criteria:

          -  Patients with known comorbid myopathy or neuropathy will be excluded from the study.

          -  Patients unable to provide their own consent will be excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Robotic Assisted Surgery for Treatment of Gynecological Diseases: Pilot Study

Eligibility criteria:
Patient Inclusion Criteria:

          -  Age ≥ 18 years old

          -  Sign the informed consent form

          -  BMI ≤ 40

          -  A.S.A. Class < III or IV

        Disease Inclusion Criteria:

          -  Ovarian cyst (enucleation/oophorectomy)

          -  Prophylactic bilateral oophorectomy

          -  Ectopic pregnancy (salpingotomy/salpingectomy)

          -  Tubal inflammatory disease (salpingotomy/salpingectomy)

          -  Infertility and sterility (treatment of endometriosis, chromo-salpingography, etc.)

          -  Benign uterine disease (Fibromatosis, Adenomyosis)

          -  Endometrial hyperplasia

          -  Stage Ia G1-2 Endometrial tumors

          -  Precancerous lesions of the uterine cervix

          -  Stage Ia uterine cervical tumors

          -  Pelvic endometriosis

        Patient Exclusion Criteria:

          -  Pregnancy

          -  Liver disease

          -  Coagulation disorders

          -  Patient internal or anatomical criteria that preclude a laparoscopic approach
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Subfertile women undergoing frozen-thawed embryo transfer with at least previously
             failed one ICSI cycle.

          -  Age between 20-35 years.

          -  Women with endometrium thickness between 8-14 mm on D15 of the frozen embryo transfer
             cycle

        Exclusion Criteria:

          -  Women with a thin endometrium (≤ 7 mm) on day 15 of the cycle.

          -  Women with known hematological or immunological disorders

          -  Women with uncontrolled endocrine or other medical conditions, such as
             hyperprolactinemia or thyroid diseases.

          -  Women with uterine abnormalities e.g. Asherman syndrome, myomas, uterine septum,
             bicornuate uterus.

          -  Women who refuse to participate in the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Safety and Efficacy of LCI699 in Cushing's Disease Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a confirmed diagnosis of Cushing's Disease (persistent or recurrent) as
             evidenced by increased 24-hour urine free cortisol (UFC), normal or increased morning
             plasma Adrenocorticotropic Hormone (ACTH), and pituitary origin of excess ACTH.

          -  Patients with de novo Cushing's disease can be included only if they are not
             considered candidate for surgery

        Exclusion Criteria:

          -  Patients treated with mitotane 6 months prior to Visit 1

          -  Patients with compression of the optic chiasm

          -  Patients with a known inherited syndrome as the cause for hormone over secretion

          -  Patients with Cushing's syndrome due to ectopic ACTH secretion or adrenal Cushing's
             syndrome

          -  Patients with pseudo-Cushing's syndrome

          -  Patients who are not biochemically euthyroid

          -  Diabetic patients with poorly controlled diabetes (HbA1c >9%)

          -  Women of child-bearing potential, defined as all women physiologically capable of
             becoming pregnant, unless they are using highly effective methods of contraception
             during dosing and for 1 week after completion of dosing.

          -  Patients who have received pituitary irradiation within five years prior to Visit 1.

          -  Patients with risk factors for QTc prolongation or Torsade de Pointes.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction