Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Demographics and Findings of Upper Endoscopy Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients who present to the KCVA GI endoscopy unit with symptoms of reflux,upper
             abdominal pain, anemia (patients referred by their primary care physicians with a
             diagnosis of low hemoglobin (< 10 G/DL, and or dyspepsia

        Exclusion Criteria:

          -  Weight loss (Weight loss of > 10% of their mean body weight over last 6 months)

          -  Dysphagia

          -  Gastrointestinal bleeding

          -  Gastrointestinal malignancy

          -  Recent EGD (in the past 5 years)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Interventional Trial of Vitamin D Deficiency in the Patients of General Departments

Eligibility criteria:
Inclusion Criteria:

          -  the patient was admitted to a general department of Rambam Medical Center for any
             reason from March to May 2008

          -  the patient is 65 years old or older

          -  the patient is in a good health, based on medical history, physical examination and
             laboratory screening evaluation.

        Exclusion Criteria:

          -  renal failure with creatinine level more then 1.3 mg/dL or nephritic syndrome.

          -  liver disease with transaminase rise three times from normal level.

          -  nephrolithiasis in the last fife years.

          -  primary hyperparathyroidism, hypoparathyroidism or pseudohypoparathyroidism.

          -  advanced cancer.

          -  chronic diarrhea or malabsorption.

          -  granulomatous disease (sarcoidosis, tuberculosis, lymphoma).

          -  patients, who are receiving barbiturates, rifampin, anticonvulsants.

          -  patients, who are receiving digitalis.

          -  patients, who are receiving glucocorticoids for more than two weeks during the study.

          -  advanced dementia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Assessment of Tremor Using SNUMAP Motion Sensing System

Eligibility criteria:
Inclusion Criteria:

          -  Age: 20-80 years

          -  Patients with tremor (involuntary, rhythmic, oscillatory movement in one or more body
             part)

          -  Subject who signed an informed consent

        Exclusion Criteria:

          -  Pregnant or nursing woman.

          -  Comorbid neurologic illnesses that impact the ability to perform the study tasks.

          -  Subjects with medical condition that in the opinion of the investigator would affect
             his/her ability to participate in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: The Effect of Dual Trigger for Final Oocyte Maturation on IVF/ICSI Outcomes in Patients With Suboptimal Ovarian Response

Eligibility criteria:
Inclusion Criteria:

        Patients with poor ovarian response (POR) diagnosis according to the POSEIDON
        stratification system (as POSEIDON group 1) with following criteria :

          -  Women' age under 35 years;

          -  Previous unexpected poor or suboptimal ovarian response after using conventional
             protocols (subgroup 1a: < 4 oocytes ) and (subgroup 1b: 4-9 oocytes retrieved)

          -  Adequate ovarian reserve (antral follicle count ≥5 on menstrual cycle day 2-3; and
             basal serum AMH ≥ 1.2 ng/ml)

        Exclusion Criteria:

          -  Ovarian failure including basal FSH above 20 IU/l or no antral follicle by ultrasound
             examination;

          -  Endometriosis grade 3 or higher;

          -  Severe male infertility (surgical sperm extraction: TESE, PESA)

          -  Body mass index >30 kg/ m2

          -  History of uterine surgery as well as sub-mucosal and intramural fibroids greater than
             5 cm or uterine polyps

          -  Treatment cycles with pre-implantation genetic diagnosis, blastocyst and donation
             embryo transfer indications

          -  Cigarette and drug addiction
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Atropine for Children and Adolescent Myopia Progression Study

Eligibility criteria:
Inclusion Criteria:

          -  children aged from 7-12 years old;

          -  children with spherical equivalent ranged from -0.5D to -6.0D;

          -  children without other eye diseases except for ametropia

        Exclusion Criteria:

          -  children with other eye diseases: amblyopia, strabismus, eye trauma, etc;

          -  children with cycloplegia contradictions;

          -  children who have used atropine;

          -  children who are severly allergic with atropine;

          -  children who are using other eye drops for treatment;

          -  children with severe heart, lung, liver and kidney diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Hypertrophic Cardiomyopathy Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed HCM

          -  Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden
             cardiac arrest

          -  Maximal left ventricular wall thickness of > 30mm

          -  Extensive fibrosis on cardiac MRI (>15% of total myocardial volume)

          -  >7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD

        Exclusion Criteria:

          -  age < 18 years

          -  Pregnancy

          -  Atrial Fibrillation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Maintenance Treatment for Children With Constipation

Eligibility criteria:
Inclusion Criteria:

          -  Children between 2 and 16 years and referral to our out patient clinic with either
             constipation or fecal incontinence.

          -  Patients must fulfill the Rome III criteria of constipation, which mean they must have
             at least 2 of the following characteristics: fewer than 3 bowel movements weekly, more
             than 1 episode of fecal incontinence weekly, large stools in the rectum by digital
             rectal examination or palpable on abdominal examination, occasional passing of large
             stools, display of retentive posturing and withholding behavior, and painful
             defecation.

        Exclusion Criteria:

          -  Children with known organic causes of constipation, including Hirsprung disease,
             spinal and anal congenital abnormalities, previous surgery on the colon, inflammatory
             bowel disease, allergy and metabolic or endocrine diseases.

          -  Children receiving drugs known to affect bowel function during a 2 month period before
             initiation.

          -  The healthy control group consists of children with no history of constipation (Rome
             III), urinary incontinence, urinary tract infections, fecal incontinence, laxative use
             or any other disease affecting the digestive system.

          -  Children receiving medications known to affect bowel function are excluded from the
             study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Efficacy of Miswak in Oral Hygiene Maintenance

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adults

          -  Able to perform their own oral hygiene

          -  Dental students

        Exclusion Criteria:

          -  Active Dental Caries

          -  Uncontrolled chronic medical conditions

          -  History of drug and/or treatment that reduces salivary flow

          -  Currently undergoing orthodontic treatment

          -  Missing index teeth #16, #12, #24, #36, #32, #44
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: RCT for Women With a Persisting Pregnancy of Unknown Location

Eligibility criteria:
Inclusion Criteria:

          1. Female with a persisting pregnancy of unknown location:

               1. A pregnancy of unknown location is defined as a women with a positive pregnancy
                  test but no definitive signs of pregnancy in the uterus or adnexa on ultrasound
                  imaging (Ultrasound must be performed within 7 days prior to randomization)

               2. Persistence of hCG is defined as 3 serial hCG values over 4-14 days or 2 serial
                  hCG values over 7-14 days, showing less than 30% rise, or less than 30% fall
                  between the first and last value. (This abnormal pattern of serial hCG confirms
                  that the gestation is nonviable.)

          2. Patient is hemodynamically stable, hemoglobin greater than 10 mg/dL,

          3. Greater than or 18 years of age

        Exclusion Criteria:

          1. Hemodynamically unstable in need of acute treatment

          2. Most recent hCG greater than 5000 IU/mL

          3. Patient obtaining care in relation to a recently completed pregnancy (delivery,
             spontaneous or elective abortion),

          4. Diagnosis of gestational trophoblastic disease,

          5. Subject unwilling or unable to comply with study procedures,

          6. Presence of clinical contraindications for treatment with methotrexate (ACOG
             guidelines, Appendix B),

          7. Prior medical or surgical management of this gestation.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype

          -  Age-matched girls without Turner's syndrome entered as controls

          -  Concurrent registration on Thomas Jefferson University growth study required of
             subjects with Turner's syndrome
Female
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment