Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery

Eligibility criteria:
Inclusion Criteria:

          -  patients undergoing laparoscopic cholecystectomy, umbilical and inguinal hernia repair

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Mirena Extension Trial

Eligibility criteria:
Inclusion Criteria:

          -  Signed and dated informed consent

          -  Women, 18 to 35 years of age at the time of screening (visit 1) who are currently
             using Mirena for contraception or for contraception and heavy menstrual bleeding. The
             duration of use of the current Mirena has to be at least 4 years 6 months at the start
             of screening phase but not more than 5 years at visit 2 and the woman is willing to
             continue with its use and has a continuing need for contraception.

          -  Normal or clinically insignificant cervical smear not requiring further follow up

        Exclusion Criteria:

          -  Menopausal symptoms with Follicle-stimulating hormone>30 mIU/ml

          -  Pregnancy or suspicion of pregnancy

          -  Uterine bleeding of unknown etiology

          -  Untreated acute cervicitis or vaginitis or other lower genital tract infections

          -  Increased susceptibility to pelvic infection

          -  Acute pelvic inflammatory disease (PID) or a history of PID unless successfully
             treated and which, in the investigator's opinion, has not negatively affected
             subject's fertility

          -  Congenital or acquired uterine anomaly if it distorts the uterine cavity

          -  History of, diagnosed or suspected genital or other malignancy and untreated cervical
             dysplasia

          -  Any active acute liver disease or liver tumor (benign or malignant)

          -  Clinically significant endometrial polyp(s)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients

Eligibility criteria:
Inclusion Criteria:

          -  ALS diagnosed as possible, laboratory-supported probable, probable, or definite as
             defined by revised El Escorial criteria.

          -  Having onset of ALS disease symptoms, including limb weakness within 24 months at the
             Screening Visit.

          -  ALSFRS-R ≥ 25 at the screening Visit.

          -  Upright slow vital capacity (SVC) measure ≥ 65% of predicted for gender, height, and
             age at the screening Visit.

          -  Rapid progressors

          -  Participants taking a stable dose of Riluzole are permitted in the study

          -  Citizen or permanent resident of the United States or Canadian citizen able to travel
             to a US site for all follow-up study visits

        Exclusion Criteria:

          -  Prior stem cell therapy of any kind

          -  History of autoimmune or other serious disease (including malignancy and immune
             deficiency) that may confound study results

          -  Current use of immunosuppressant medication or anticoagulants (per Investigator
             discretion)

          -  Exposure to any other experimental agent or participation in an ALS clinical trial
             within 30 days prior to Screening Visit

          -  Use of RADICAVA (edaravone injection) within 30 days of screening or intent to use
             edaravone at any time during the course of the study including the follow up period

          -  Use of non-invasive ventilation (BIPAP), diaphragm pacing system or invasive
             ventilation (tracheostomy)

          -  Feeding tube

          -  Pregnant women or women currently breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Guided Self-help for Families With an Overweight Child

Eligibility criteria:
Inclusion Criteria:

          -  child between the ages of 8 & 12

          -  an moderately overweight child with a BMI% between 85-97%

          -  child has a parent willing to participate

          -  child has a parent who can read English at a minimum of a 6th grade level

          -  family who is willing to commit to treatment attendance and attendance at all
             assessments.

        Exclusion Criteria:

          -  Child psychiatric disorder diagnoses (based on parent report)

          -  Child diagnoses of a serious current physical disease (such as diabetes)

          -  Child who is taking medications that may impact their weight

          -  Child with physical difficulties that limit the ability to exercise

          -  Child with an active eating disorder

          -  Child and parent will be moving out of the San Diego County before study completion

          -  Child and/or parent has a modified diet due to religious or socially conscious reasons
             (such as Vegan, vegetarian)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Evaluation of a Revised Indication for Determining Adult Cochlear Implant Candidacy

Eligibility criteria:
Inclusion Criteria:

          -  Eighteen years of age or older at the time of the study.

          -  Preoperative aided CNC word score in quiet of greater than or equal to 10% and less
             than or equal to ¬¬40% in the ear to be implanted; equal to but no better than 50% in
             the contralateral ear

          -  Bilateral moderate to profound hearing loss in the low frequencies (up to 1000 Hz) and
             profound sensorineural hearing loss in the high speech frequencies (3000 Hz and above)

          -  Willingness to use bimodal stimulation (i.e. a cochlear implant on one ear and a
             hearing aid on the contralateral ear) through at least 6-months postactivation.

          -  English spoken as the primary language.

        Exclusion Criteria:

          -  Congenital hearing loss (for the purpose of this study, onset prior to 2
             years-of-age).

          -  Preoperative aided HINT sentence score less than or equal to 50% in the ear to be
             implanted

          -  Ossification, absence of cochlear development or any other cochlear anomaly that might
             prevent complete insertion of the electrode array.

          -  Hearing loss of neural or central origin (e.g., deafness due to lesions on the
             acoustic nerve or central auditory pathway).

          -  Active middle-ear infection.

          -  Unwillingness and/or inability of the candidate to comply with all investigational
             requirements including, but not limited to, study protocol and surgical procedure.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluation of SCT800 in Prophylaxis Therapy on Previous Treated Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Aged ≥12 years old and ≤65 years old;

          -  Male patients who are clinically diagnosed with severe (laboratory tested FVIII:C <1%)
             hemophilia A, including historical FVIII:C <1%;

          -  Previously received FVIII treatment (prophylactic or bleeding treatment), have the
             relevant records and are verified to have accumulated exposures days( EDs) ≥150 days;

          -  The bleeding treatment records of at least 3 months before screening can be obtained;

          -  Negative FVIII inhibitor assay results (laboratory tested Nijmegen-Bethesda assay
             result <0.6 BU(Bethesda unit)/mL);

          -  The prothrombin time is normal or international normalized ratio (INR) ≤1.5; 7.
             Platelet count ≥100 × 109/L;

        Exclusion Criteria:

          -  Known allergy to recombinant coagulation factor VIII concentrate or any excipient;
             known allergy to bovine, rodent or hamster bovine;

          -  Has a history or family history of blood coagulation factor VIII inhibitor;

          -  Clinical liver function test (glutamic-pyruvic transaminase, glutamic-pyruvic
             transaminase) ≥ three times the upper limit of normal (ULN) or clinical kidney
             function test (blood urea nitrogen, creatinine) ≥ three times the ULN;

          -  Patients clinically diagnosed with active Hepatitis B or Hepatitis C;

          -  Patients with other coagulation dysfunction diseases in addition to hemophilia A;

          -  Patients with severe heart disease, including myocardial infarction and cardiac
             dysfunction of class III or above;

          -  Patients who previously experienced intracranial bleeding;
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Evaluation of Ultra-portable Ultrasound in General Practice

Eligibility criteria:
Inclusion Criteria:

          -  patients age 18 and over

          -  consulting their general practitioner for one of the 8 conditions below

        Exclusion Criteria:

          -  patients who have already received an imagery exam for the acute episode justifying
             the consult

          -  opposition to participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Clomiphene in Males With Prolactinomas and Persistent Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  a minimum follow-up of 6 months under DA therapy with normal serum prolactin or with
             maximum DA dose (3.5 mg/week of cabergoline or 10 mg/day of bromocriptine for at least
             2 months)

          -  serum total testosterone less than 300ng/dl with normal or low LH and FSH levels after
             discontinuing testosterone replacement for at least 2 months.

        Exclusion Criteria:

          -  impossibility to attend scheduled visits and irregular compliance to DA treatment.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction