Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility

Eligibility criteria:
Inclusion Criteria:

          -  idiopathic oligozoospermia (spermatozoid number <2x10^6/mL) - 10 patients

          -  cryptozoospermia/azoospermia - 10 patients

        Exclusion Criteria:

          -  age before 18 or after 60 years old

          -  heart insufficiency. stroke (during 1 year)

          -  anemia

          -  blood disease

          -  pelvis bone trauma

          -  chronic diseases in decompensation stage

          -  skin diseases

          -  tuberculosis

          -  hyperprolactinaemia

          -  hyper or hypothyreosis

          -  obstructive zoospermia

          -  sperm stimulating hormone therapy

          -  Men with previous surgery in testis

          -  Men with infectious genital diseases and anatomical abnormalities of the genital tract

          -  Those with major medical problems such as malignancy, hepatitis B . C, etc. HIV

          -  Chromosomal aberration (e.g. Y microdeletion, trisomy….)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Efficacy and Tolerability of Topical Rossoseq™ Compared to Vehicle in Rosacea Subtype 1 (Erythematotelangiectatic)

Eligibility criteria:
Inclusion Criteria:

          -  Signed and dated informed consent prior to any study-mandated procedure

          -  Clinically diagnosed rosacea defined by a score of ≥6 and ≤15 out of a maximum score
             of 30 for the primary and secondary features of the RSGS

          -  Female subjects of childbearing potential must be using appropriate birth control

        Main exclusion Criteria:

          -  Pregnancy or lactation

          -  Women with the following menopausal symptoms within the last two years prior to
             screening: excessive sweating, flushing, mood changes

          -  Ocular manifestations of rosacea

          -  Peripheral location(s) of rosacea

          -  Phymatous changes

          -  Severe facial skin dryness or xerosis

          -  Keratoconjunctivitis sicca

          -  Flushing due to conditions other than rosacea

          -  Any other abnormal facial skin conditions, e.g., eczema, perioral dermatitis, broken
             and bleeding skin on area of application

          -  Malignancy within the past 2 years with the exception of in situ removal of basal cell
             carcinoma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia)

Eligibility criteria:
Inclusion Criteria:

          -  male or female subjects 18 years or older

          -  documented diagnoses of hypertension and of hypercholesterolemia or current therapy
             for these conditions

          -  uncontrolled hypertension (SBP >140 mmHg or DBP >90 mmHg) or cholesterol levels above
             their threshold based on their global atherosclerotic risk profile (based on ATP III
             assessment)

          -  ability to give written informed consent

        Exclusion Criteria:

          -  ischemic heart disease, atrial fibrillation, chronic kidney disease and significant
             liver disease

          -  currently prescribed 3 or more drugs to control blood pressure

          -  currently prescribed 2 or more drugs to control hypercholesterolemia

          -  participating in other hypertension/hypercholesterolemia studies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied Twice Daily Versus Once Daily

Eligibility criteria:
Inclusion Criteria:

        - Papulopustular facial rosacea; minimum of 10, maximum of 50 inflamed papules and/or
        pustules

        Exclusion Criteria:

          -  Mild or severe rosacea

          -  Rosacea with marked ocular manifestations

          -  Presence of dermatoses that could interfere with the rosacea diagnosis or evaluation
             of the study course

          -  Wash out period required for patients treated prior to study with topical retinoids,
             oral antibiotics, topical antibiotics, systemic and topical corticosteroids, topical
             imidazole, laser surgery for telangiectasia

          -  History of hypersensitivity to propylene glycol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Concomitant Administration of FSH With HCG Improves Oocyte Maturation and Quality Double -Blinded Randomized Trial

Eligibility criteria:
Inclusion Criteria:

          -  patients undergoing in vitro fertilization

        Exclusion Criteria:

          -  risk of ovarian hyperstimulation syndrome
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patient over 19 years old

          -  Patient with typical GERD symptom (heartburn or acid reflux more than once a week)

        Exclusion Criteria:

          -  Patient who received EGD since the past 6 months, and diagnosed as GERD endoscopically

          -  Patient with active gastric/duodenal ulcer

          -  Patient who received esophagus, stomach or duodenum surgery

          -  Patient with hypersensitivity to esomezol®

          -  Patient with no achieved agreement on the study from the guardian or patient himself.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe)

Eligibility criteria:
Inclusion Criteria:

          -  Age-matched (18-100)

          -  Healthy normal controls with no known hearing loss

          -  Patients with clinically assessed hearing loss

        Exclusion Criteria:

          -  Complete hearing loss/deafness

          -  Cognitive decline or dysfunction, dementia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Application of a Systematic Developmental Assessment to a Novel Population: Infants With Rare Genetic Disorders

Eligibility criteria:
Inclusion Criteria:

          -  Eligible patients are infants under 4 years of age with genetic disorders undergoing
             developmental surveillance in the NICU GraDS program.

        Exclusion Criteria:

          -  Children 4 years of age or older will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 4 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Genetics of Mendelian Forms of Young Onset Alzheimer Disease

Eligibility criteria:
Inclusion Criteria:

          -  > in one family 2 cases of Alzheimer disease with age of onset under 65

        Exclusion Criteria:

          -  other cases of young onset dementia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: The Hemophilia Ultrasound Project

Eligibility criteria:
Inclusion Criteria:

          -  Severe Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis of
             severe hemophilia A or B defined as a factor VIII:C/IX:C of <1% undergoing prophylaxis
             regimen with any factor VIII or IX concentrate and without evidence (clinical or by
             history) of target joint disease.

          -  Mild/moderate Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis
             of mild hemophilia A or B defined as a factor VIII:C/IX:C of 5-50% and those with
             diagnosis of moderate hemophilia A or B defined a s a factor VIII:C/IX:C of 1-5%
             without evidence (clinical or by history) of target joint disease and no history of
             spontaneous joint bleeds.

        Exclusion Criteria:

          -  Patients with concomitant Hepatitis B, Hepatitis C and HIV viral infections (because
             of a recognized arthritogen effect).

          -  Present or prior history of anti FVIII or IX inhibitors.

          -  Known inflammatory joint disease.

          -  Established target joint.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 30 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Prediction of Clinical Course in COVID19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  age ≥ 18 years

          -  clinical suspicion of COVID-19 confirmed by RT-PCR

          -  CT scan at ER admission

          -  RT-PCR sampling

        Exclusion Criteria:

          -  CT scan failure or loss of CT data

          -  RT-PCR initial results unavailable
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction