Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Central Venous Pressure (CVP) Assessment by Ultrasound and Physical Examination

Eligibility criteria:
Inclusion Criteria:

          -  adult medical or surgical ICU patients who have preexisting central venous
             (jugular/subclavian only) catheters.

        Exclusion Criteria:

          -  subjects with only a femoral venous catheter.

          -  subjects whose CVP measurement by the indwelling catheter exceeds 20cm of water.

          -  subjects younger than 18 years old.

          -  inability to obtain informed consent from the subject or the subjects authorized
             representative.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparison of Uterine Peristaltic Wave Frequencies Between Pregnant and Non-pregnant Women in Embryo Transfer Cycles

Eligibility criteria:
Inclusion Criteria:

          -  women age < 45years

          -  BMI < 35 kg/m2

          -  at least one of good quality embryo in embryo transfer cycle by Istanbul consensus
             workshop morphologic grading Day3 : Grade 1-2, Day4 : Grade 1-2 , Day5 : stage of
             development grade 2-4

        Exclusion Criteria:

          -  structural intrauterine cavity distortion

          -  leiomyoma FIGO subclassification 3

          -  adenomyosis

          -  recurrent pregnancy loss

          -  recurrent implantation failure

          -  urerine relaxant drugs

          -  difficult embryo transfer
Female
Accepts Healthy Volunteers

Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis

Eligibility criteria:
Inclusion Criteria:

          1. Children with a diagnosis of atopic dermatitis that meet Hanifin and Rajka criteria

          2. SCORAD ( SCORing Atopic Dermatitis) index 15- 50 at the time of enrollment

        Exclusion Criteria:

          1. SCORAD (SCORing Atopic Dermatitis) index <15 or >50.

          2. Children treated with systemic corticosteroids, methotrexate, or cyclosporine in the
             previous 3 months and antibiotics in the previous 2 weeks.

          3. Immunocompromised children.

          4. Concomitant diagnosis of intolerance to gluten and/ or lactose.

          5. Pre-existing hypersensitivity to components contained in the probiotics.

          6. Children suffering from chronic infectious diseases.

          7. A child with other known systemic diseases (heart, liver or kidney diseases).

          8. Known case of short gut syndrome.

          9. Refusal of children's parents to participate in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension

Eligibility criteria:
Inclusion Criteria:

          -  Osteoarthritis of the hand, hip, knee or spine

          -  High blood pressure (<140/ 90 mmHg) which is controlled by antihypertensive
             medication(s).

        Exclusion criteria

        • Evidence or history of any cardiac and cerebral thrombotic/ ischemic diseases and/ or
        events

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.

Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  All patients over 18 years old

          -  All non pregnant women

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Single-port Access Laparoscopic-assisted Vaginal Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Patients receive laparoscopic-assisted vaginal hysterectomy (LAVH)

          -  American Society of Anesthesiologists (ASA) physical status of patient: classification
             I-II

        Exclusion Criteria:

          -  The procedure will be required to conversion to laparotomy.

          -  Cancer
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Stapler Versus Glue for Laparoscopic Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  patients scheduled for laparoscopic primary inguinal hernia repair

          -  uni- or bilateral patients with recurrent hernias after anterior surgical technique

          -  written informed consent

        Exclusion Criteria:

          -  general contradictions for laparoscopy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation

Eligibility criteria:
Key Inclusion Criteria:

          -  Diagnosis of clinically possible, clinically probable (with or without laboratory
             support), or clinically definite ALS (using the revised El Escorial Criteria)

          -  Forced vital capacity greater than or equal to 65% of that predicted for age and
             height

          -  Onset of ALS-related weakness less than 3 years prior to first dose of study drug

          -  Plasma high sensitivity C-reactive protein (hs-CRP) concentration of greater than or
             equal to 0.113 mg/dL at pre-screening/screening

          -  Stable dose (greater than 30 days) of riluzole if undergoing treatment with this agent

          -  For females: Not be of childbearing potential or agree to use adequate birth control
             during the study

        Key Exclusion Criteria:

          -  Life expectancy of less than 6 months

          -  Tracheotomy or be using ventilatory assistance, including Bi-level Positive Airway
             Pressure (BiPAP) or Continuous Positive Airway Pressure (CPAP)

          -  Active pulmonary disease

          -  Gastrostomy

          -  Stem cell therapy

          -  Immune modulator therapy or participation in studies of other agents within 12 weeks
             of pre-screening/screening

          -  Unstable medical condition other than ALS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects

Eligibility criteria:
Inclusion Criteria:

          -  Primary, unilateral or bilateral, inguinal hernia patients

          -  Informed consent

        Exclusion Criteria:

          -  Sterilized patients
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Oxidative Stress in Testicular Tissue Before and After Cryopreservation

Eligibility criteria:
Inclusion Criteria:

        - Men with azoospermia at reproductive age .

        Exclusion Criteria:

          -  Pyospermia.

          -  Previous trial of cryopreservation.

          -  Systemic diseases.

          -  Cryptorchidism history.

          -  Smoking
Male

Subject must be at least 14 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Ambulatory postmenopausal Korean women, ≥ 55 to ≤ 90 years of age at enrollment.

          -  Postmenopause is defined as no spontaneous vaginal bleeding or spotting for 12 or more
             consecutive months prior to screening.

          -  BMD T-score </= -2.50 at the lumbar spine, total hip or femoral neck.

          -  At least 2 vertebrae in the L1 through L4 region and at least one hip are evaluable by
             DXA.

          -  Other inclusion criteria may apply.

        Exclusion Criteria:

          -  Subjects with a BMD T-score </= -4.0 at the lumbar spine, total hip, or femoral neck.

          -  History of hip fracture.

          -  Bone disease other than osteoporosis/ or evidence of any other clinically significant
             disorder, condition/ or disease or significant laboratory abnormalities.

          -  Known sensitivity or intolerance calcium and vitamin D products.

          -  Other exclusion criteria may apply.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction