Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET

Eligibility criteria:
IVF

        Inclusion criteria:

        - Women aged <43 years at the time of IVF treatment

        Exclusion criteria:

          -  Preimplantation genetic diagnosis treatment

          -  Use of donor oocytes or donor embryos

          -  Hydrosalpinx shown on pelvic scanning and not surgically treated

          -  Women at risk of OHSS

        FET

        Inclusion criteria:

          -  Women aged <43 years at the time of IVF treatment

          -  Replacing early cleavage embryos or blastocysts after thawing

          -  FET in natural cycles

        Exclusion criteria:

          -  Frozen early cleavage embryos thawed and cultured to blastocysts prior to transfer as
             requested by the patient

          -  Preimplantation genetic diagnosis treatment

          -  Use of donor oocytes or donor embryos

          -  Hydrosalpinx shown on pelvic scanning and not surgically treated
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Role of the Robotic Platform in Inguinal Hernia Repair Surgery

Eligibility criteria:
Inclusion Criteria:

          1. 21 years or older

          2. No prior open abdominal surgery at or below the umbilicus

          3. Primary or recurrent unilateral inguinal hernia repair

          4. No previous preperitoneal mesh placement

          5. BMI less than or equal to 40kg/m2

        Exclusion Criteria:

          1. Need for an open inguinal hernia repair

          2. Patients presenting for evaluation of bilateral inguinal hernias

          3. Patients requiring surgical repair of a strangulated inguinal hernia

          4. Patients with liver disease defined by the presence of ascites

          5. Patients with end-stage renal disease requiring dialysis

          6. Patients who are unable to give informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Intra and Inter Reliability of 30 Seconds Chair Stand Test as Self-test for Patients With Knee Osteoarthritis.

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with knee osteoarthritis. The patients should have most problem
             with their knees, but are allowed to have osteoarthritis in other lower extremity
             joints.

          -  Independent in walking, with or without walking aids.

          -  Understand test instructions verbally and in writing.

        Exclusion Criteria:

          -  Neurological disorders that affects the patients balance or gait.

          -  Severe somatic or mental illness that affect the physical functional performance or
             the ability to understand test instructions verbally or in text.

          -  Knee or hip replacement the past six months.

          -  Other knee surgery the past six months that could affect the physical functional
             performance.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: rhGH Therapy on Hepatic Drug Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  Children ages 4 to 14 years with a height less than the 5th percentile for age and sex
             or having a decelerated across two major percentiles (5th, 10th, 25th, 50th, 90th, and
             95th) on standard pediatric growth curves, poor growth velocity (less than 5
             centimeters/year), radiographic evidence of delayed bone age (i.e. greater than 1 SD
             below the mean for chronological age) and a documented diagnosis of idiopathic growth
             hormone deficiency [as determined by failure to raise serum GH concentrations 10
             microgram/Liter following provocative testing with two growth hormone
             secretagogues(e.g. insulin, arginine, or clonidine)].

          -  All subjects will be prepubertal, as determined by Tanner staging.

        Exclusion Criteria:

          -  Children receiving medications known to induce or inhibit hepatic CYP1A2, NAT-2, XO,
             CYP2D6 or CYP3A4 activity.

          -  Subjects with a history of smoking (including exposure to second hand smoke > 8 hours
             per day) or illicit drug use.

          -  Subjects with a history of hepatic, renal, cardiac or thyroid disorders. Presence of
             hepatic, renal, cardiac or thyroid disease will be established based on clinical
             history and results of recent laboratory tests conducted as part of the routine
             medical evaluation of children who are being considered for rhGH therapy.

          -  Children experiencing fever or acute viral illness

          -  Children who have a history of a hypersensitivity reaction to dextromethorphan or
             caffeine

          -  Children who have received prior treatment with rhGH

          -  Children who are receiving corticosteroids or thyroid hormone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion

Eligibility criteria:
Inclusion Criteria:

          -  Singleton pregnancy.

          -  Primigravida or multigravida.

          -  Gestational age ≤ 20 weeks.

          -  Missed abortion.

        Exclusion Criteria:

          -  Maternal age < 18 years.

          -  Twin pregnancy.

          -  Previous cesarean section.

          -  Allergy to letrozole or misoprostol.

          -  Liver cirrhosis or severe liver impairment.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Osteoarthritis Treatment With Adipose-derived Stem Cells: Phase II Clinical Trial

Eligibility criteria:
Inclusion Criteria:

          -  age between 45 and 65.

          -  Participants having Knee osteoarthritis grade 2 or higher "Kellgren and Lawrence
             scale"

          -  Participants had an average pain intensity of grade 4 or more on a 10-point visual
             analog for at least one year.

        Exclusion Criteria:

          -  Patient with history of rheumatic or chronic inflammatory diseases

          -  Patient poorly controlled diabetes,

          -  Patient who currently on OA treatment such as corticosteroids, chondroitin sulfate,
             glucosamine or hyaluronic acid.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  60 years or older

          -  Having difficulty sleeping over the past three months (Insomnia Severity Index ≥ 8)

          -  Having osteoarthritis pain (Brief Pain Inventory Worst pain ≥ 4)

        Exclusion Criteria:

          -  Working night shift

          -  Previously diagnosed with a primary sleep disorder (Sleep Apnea or Restless Leg
             Syndrome).

          -  Seizure disorder

          -  Photosensitivity

          -  Dementia

          -  Diagnosis or other significant chronic illness beyond OA that would impact sleep

          -  Severe psychiatric disorder including a history of or current diagnosis of psychosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: "Examination of the Impact of a Dynamic Flexion Orthosis (Dynaflex®Ottobock) or of a Back Bandage (Lumbo Sensa®Ottobock) on the Voluntary Activation of the Back Muscles in Patients With Specific Back Pain"

Eligibility criteria:
Inclusion Criteria:

        for the application with Dynaflex®:

          -  central or foraminal lumbar stenosis, Claudicatio spinalis pathology

          -  degenerative lumbar instability (e.g. Spondylolisthesis) with lumboischialgia or
             Claudicatio spinalis pathology

          -  herniated vertebral disk with forms of ischialgia pain

          -  age: 18-80 years

        additionally for the application with LumboSensa®:

          -  scoliosis

          -  osteoporosis

          -  inflammatory rheumatic back pain

          -  Failed Back Surgery Syndrome

          -  painful conditions after stabilizing or reinforcing surgeries

        Exclusion Criteria:

          -  paresis of the lower extremity

          -  contact allergy to orthotic material

          -  diseases in body regions with contact to orthosis, which become manifest
             neurologically/dermatologically

          -  acute Spondylodiscitis

          -  tumor diseases

          -  recent vertebral body fractures

          -  pregnant and lactating females

          -  subject has been committed to an institution by legal or regulatory order

          -  dependency or working relationship with the investigator

          -  participation in a parallel interventional clinical study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Study of the Effects Strengthening Exercises in Individuals With ALS

Eligibility criteria:
Inclusion Criteria:

          -  definite and/or probable diagnosis of ALS

          -  early stages of the disease

        Exclusion Criteria:

          -  history of neuromuscular dysfunction not related to ALS

          -  active, confounding medical conditions

          -  unwillingness or inability to comply with the protocol

          -  FVC of less than 90% predicted

          -  ALSFRS score of less than 30
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy

Eligibility criteria:
Inclusion Criteria:

          -  18 - 60 years old

          -  ASA (I and II)

          -  Hb level > 10 mg/dl

          -  elective ear exploratory tympanotomy surgery under general anesthesia.

        Exclusion Criteria:

          -  Allergy to TXA

          -  bleeding/coagulation disorders

          -  psychiatric illness

          -  acute and chronic renal failure

          -  heparin use within 48 hrs or aspirin use within seven days before surgery,

          -  pregnancy

          -  liver cirrhosis

          -  color blindness

          -  cardiac stent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment