Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Characterizing the Impact and Treatment of Reproductive Tract Bleeding on Women and Post-menarchal Girls With Bleeding Disorders

Eligibility criteria:
Inclusion Criteria:

          -  Women and girls with an active diagnosis of a congenital bleeding disorder (as
             designated by the institution inputting data);

               1. Deficiencies of factors VIII, IX, II, V, VII, VII, IX, X, XI, FV+VIII, XIII,
                  Plasminogen Activator Inhibitor 1(PAI-1), hypo-, a-, or dys-fibrinogenemia

               2. von Willebrand Disease (Type 1, Type 1c, Type 2A, Type 2B, Type 2M, Type 2N, Type
                  3, Low VWF)

               3. Any platelet function disorder (i.e. Glanzmann Thrombasthenia, Bernard Soulier
                  Syndrome, Platelet Storage Pool disorder, MYH9 disorders, Gray Platelet syndrome,
                  Dense granule deficiency)

               4. Ehlers Danlos Syndrome

          -  Post-menarchal: has had at least 1 period at the time of study entry

          -  Participating in the ATHNdataset

        Exclusion Criteria:

          -  Male gender

          -  Acquired bleeding disorder

          -  Thrombotic disorder

          -  Non-English speaking
Female
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study v1.0

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Food, Fun, & Fitness Internet Program for Girls: Outcome Evaluation

Eligibility criteria:
Inclusion Criteria:

          -  8-10 years old

          -  healthy

          -  African American

          -  parent willing to participate in data collection

          -  internet access

          -  personal email address

        Exclusion Criteria:

          -  mental, physical, or medical conditions that limit fruit-vegetable consumption,
             physical activity, or ability to fully participate in the program and/or complete
             baseline and post assessment data collection

          -  taking medications that influence dietary behaviors, appetite, and/or physical
             activity
Female
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Quantitative MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile Male

Eligibility criteria:
Inclusion Criteria:

          -  Men with normospermia who are initiating testosterone replacement and are over 18
             years of age will provide semen samples to NYU Fertility Center.

        Exclusion Criteria:

          -  Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial
             heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the
             eye, or steel implants.

          -  Substance abuse, medical, psychological, or social conditions that may interfere with
             the patient's participation in the study.

          -  All women are excluded as such patients do not have the relevant anatomy being
             considered in this study.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease.

Eligibility criteria:
Inclusion Criteria:

          -  adult patients, 50-90 years of age;

          -  diagnosis of probable Alzheimer Disease, with symptoms >=1 year prior to screening;

          -  meets DSM-IV criteria for Alzheimer-type dementia;

          -  stabilised on approved medications for treatment of Alzheimer Disease for >=4 months
             prior to baseline.

        Exclusion Criteria:

          -  active major depressive disorder, or a history of bipolar disorder;

          -  history of schizophrenia;

          -  concurrent participation in a non-pharmacological trial with a key objective of
             improving cognition;

          -  prior randomisation in any R1450 trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Processing of Music in Alzheimer Patients

Eligibility criteria:
Inclusion Criteria:

        Diagnosed Alzheimer´s disease

        Exclusion Criteria:

        Other neurological comorbidity, substance abuse
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Genetic and Blood Biomarkers in Neurological and Neuromuscular Diseases

Eligibility criteria:
Inclusion Criteria:

          -  Subjects will be individuals with neurologic or neuromuscular disease who are deemed
             well-enough for sample collection.

        Exclusion Criteria:

          -  Subjects who are not willing to undergo sample collection, genetic analysis, or
             unwilling to share clinical information or their samples.

          -  Pregnant women will also be excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Year old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Transcranial Direct Current Stimulation as a Novel Therapeutic Approach in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of probable, laboratory-supported probable, or definite amyotrophic lateral
             sclerosis according to the El Escorial revised criteria

          -  spinal onset

          -  aged 18 to 85 years inclusive

          -  disease duration ≤ 24 months

          -  disease progression in the past 3 months

          -  FVC ≥ 70% of predicted

          -  score ≥ 2 at the item "swallowing"of the ALS Functional Rating Scale Revised

          -  score ≥ 2 at the item "walking"of the ALS Functional Rating Scale Revised

          -  in treatment with steady regimen of riluzole for a minimum of 1 month before study
             entry, and desiring its continuation

          -  able to give informed consent

          -  written informed consent

        Exclusion Criteria:

          -  bulbar onset

          -  previous poliomyelitis

          -  motor neuron diseases other than ALS

          -  clinical involvement of other neurological systems

          -  pregnancy, lactation,or unwillingness to contraception if required

          -  possible contraindications to tDCS: metals in the head (excluding the mouth);
             electromedical devices; seizures; drugs or neurological conditions lowering seizure
             threshold; alcoholism; severe heart diseases

          -  any severe disease other than ALS

          -  experimental drugs within 1 month prior to enrollment

          -  drugs potentially modifying the response to tDCS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of refractory essential tremor scheduled for unilateral thalamic deep brain
             stimulator placement

          -  Age ≥ 18 years

        Exclusion Criteria:

          -  Prior deep brain stimulator, stereotactic radiosurgery, or focused ultrasound
             procedure for treatment of tremor

          -  Presence of concomitant movement disorder (e.g. Parkinson's disease, dystonia, etc.)

          -  Known pre-existing structural brain abnormality (e.g, infarction, tumor, prior brain
             surgery, etc.)

          -  Contraindication to 3 Tesla brain MRI (e.g. incompatible implanted device)

          -  Pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Influence of Administration Route of Testosterone on Male Fertility

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than or equal to 50 years but not older than 80 years of age;

          -  Serum testosterone level <13.8 nmol/l;

          -  Sperm concentration > 40 Million/ml;

          -  Willing to give written informed consent.

        Exclusion Criteria:

          -  Testicular diseases or having had any surgical procedures applied to the testes;

          -  History or currently existing serious disease of any type, in particular liver, kidney
             or heart disease, any form of diabetes mellitus, cancer or psychiatric illness;

          -  Current androgen, anabolic steroid or sex hormone treatment or any treatment with such
             compounds in the previous 6 months;

          -  Blood donation within the 12-week period before the initial study dose.

          -  History of, or current nasal disorders (e.g. seasonal or perennial allergic rhinitis,
             atrophic rhinitis, polyposis, abuse of nasal decongestants, clinically relevant nasal
             septum deviation, recurrent epistaxis) or sleep apnea;

          -  Elevated serum PSA levels (> 4 ng/ml for subjects >= 50 years of age);
Male
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction