Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Menstrual Cycle Symptom Tracking

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Aged 18 years and over

          -  Regular menstrual cycles

          -  Owns a compatible smart phone i.e. iPhones® and AndroidTM phones equipped with
             Bluetooth® 4.0/BLE

          -  Willing to use their own smartphone for the duration of this study and to download and
             install the study app

          -  Willing to give informed consent

        Exclusion Criteria:

          -  Currently trying to conceive

          -  Currently or recently pregnant or breastfeeding

          -  Taking any treatment which may affect the menstrual cycle (e.g. contraceptive pill,
             fertility medications or hormone replacement therapy)

          -  Taking or undergoing any other medical treatment for fertility such as ovulation
             drugs, artificial insemination and assisted fertility such as In vitro fertilization
             (IVF) or Intracytoplasmic sperm injection (ICSI)

          -  Has abnormal liver or kidney function

          -  Taking antibiotics containing tetracycline

          -  Taking clomiphene citrate or other ovulation induction drugs
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate to severe dry eye syndrome with or without Sjogren's syndrome or
             other autoimmune disease

        Exclusion Criteria:

          -  Intraocular or refractive surgery in the study eye within 3 months prior to study
             start

          -  Unwilling to discontinue use of contact lenses during the run-in and duration of the
             study

          -  Pregnancy or lactation
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Osteoarthritis Care: A Quality Improvement Intervention in Physiotherapists

Eligibility criteria:
Inclusion Criteria:

          -  patients with knee osteoarthritis, treated by a participating physiotherapist within a
             predefined period

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Effect of Oral Procaterol on Postinfectious Persistent Cough

Eligibility criteria:
Inclusion Criteria:

          1. Having persistent cough that lasts longer than 3 weeks following URTI

          2. Currently being a non-smoker

          3. Having normal spirometry (FEV1>or= 80% predicted)

          4. Obtain consent form

        Exclusion Criteria:

          1. Having cough more than 8 weeks

          2. Having history of allergic or intolerance to β2 agonist

          3. Having diagnosis of asthma by physicians

          4. Presence of wheeze or rhonchi on physical examination

          5. Having radiographic evidence of pneumonia, tuberculosis or sinusitis

          6. Having significant gastroesophageal reflux symptoms suggested by GERD-Q questionnaire
             (GERD-Q score > 8)

          7. Currently taking ACE-inhibitor

          8. Being active smokers

          9. Refuse to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study.

Eligibility criteria:
For participants with major depressive episode:

        Inclusion criteria:

          -  female sex

          -  current diagnosis of a major depression episode

          -  minimum age of 18 years

          -  regular menstrual cycle.

        Exclusion criteria:

          -  Pregnancy less than one year ago;

          -  women who are breastfeeding;

          -  bipolar disorder;

          -  acute suicidal tendencies;

          -  schizophrenic disorders (F20-29);

          -  substance use disorders

          -  psychotropic drugs in the last six months;

          -  chronic somatic diseases.

        For participants without major depressive episode:

        Inclusion criteria:

          -  female sex;

          -  minimum age of 18 years;

          -  regular menstrual cycle.

        Exclusion criteria:

          -  current or lifetime mental disorder;

          -  pregnancy less than one year ago;

          -  women who are breastfeeding;

          -  psychotropic drugs in the last six months;

          -  chronic somatic diseases.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Down syndrome without mosaicism

          -  age 3 to 30 months

          -  weight over 4 kg

          -  possible assessment by the revised Brunet-Lezine scale

        Exclusion Criteria:

          -  history of leukemia

          -  West syndrome or non-stable epilepsy

          -  non-stable thyroxin treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 30 Months

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Efficacy And Safety Of Thoracoscopic Cryobiopsy In Patients With Undiagnosed Exudative Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  patients diagnosed as exudative pleural effusion according to Light criteria .informed
             written consents were taken from all patients enrolled in the study

        Exclusion Criteria:

          -  patients who refused participation ,patients unfit for medical thoracoscopy (MT) will
             be excluded from the study such as:Uncooperative patient ,Severe uncorrected hypoxemia
             in spite of continuous oxygen administration, because it's necessary to keep oxygen
             saturation above 90 % during procedure ,patients who could not tolerate the lateral
             decubitus position for a period long adequate to do the thoracoscopy, unstable
             cardiovascular or hemodynamic condition, uncorrected Coagulation defects and small
             pleural space
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Mirena or Conventional Medical Treatment for Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
             next year

          -  Women complaining of heavy menstrual bleeding over several consecutive cycles

          -  Women without structural or histological abnormality of the uterus, or with fibroids
             less than 3 cm in diameter which are causing no distortion of the uterine cavity
             (eligible for pharmaceutical treatment according to the NICE guideline 2007)

          -  Informed consent (where required by laws or regulations)

        Exclusion Criteria:

          -  The contraindications and warnings of the respective Summary of Product
             Characteristics (Mirena, combined oral contraceptives, oral/injectable progestogens,
             non-steroidal anti-inflammatory drug, or anti-fibrinolytic agent) must be followed.

          -  Women taking hormone replacement therapy

          -  Women with symptoms such as intermenstrual or post-coital bleeding, unless an
             endometrial biopsy has been performed and pathology excluded

          -  Women with fibroids that are palpable abdominally or who have intra-cavity fibroids
             and/or whose uterine length as measured at ultrasound or hysteroscopy is greater than
             12 cm (NICE guideline 2007)

          -  Women on anticoagulative therapy or other treatment (including e.g. Copper IUD use)
             known to cause menorrhagia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: A Nurse Led Patient Management Programme to Improve Outcomes in Gout

Eligibility criteria:
Inclusion Criteria:

          -  Proven diagnosis of gout according to aspiration of Monosodium urate (MSU) crystals or
             positive dual energy computer tomography (DECT) or American college of rheumatology
             (ACR) criteria 2015 fulfilled (1)

          -  written informed consent

          -  age >=18 years

          -  ability and willingness to follow a fixed outpatient programme as judged by the
             investigator

          -  indication for urate-lowering therapy (ULT)

          -  In case of established disease and intercritical gout a SUA level over 360 umol per
             liter is mandatory.

        Exclusion Criteria:

          -  informed consent not obtained

          -  age <18 years

          -  inability or unwillingness to follow a fixed outpatient programme as judged by the
             investigator

          -  no definite diagnosis of Gout

          -  no indication for ULT or contraindications against ULT

          -  in case of established disease and intercritical gout a SUA level <360 umol per liter
             is an exclusion criterion

          -  Pregnant or breastfeeding women can´t participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Radial Nerve Block for Treatment of Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  18 years and above

          -  presenting with refractory elbow pain

        Exclusion Criteria:

        patients with:

          -  osteoarthritis,

          -  rheumatoid arthritis,

          -  olecranon bursitis,

          -  radial nerve entrapment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction