Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Tencel vs. Standard Cotton Therapeutic Garments as an Adjunct Treatment for Moderate to Severe Atopic Dermatitis in Children

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate or severe atopic dermatitis based on Eczema Area and Severity
             Index (EASI) score (moderate=6-22.9; severe=23-72)

          -  At least one active patch of atopic dermatitis at time of study

          -  Parent/guardian able to give informed consent

        Exclusion Criteria:

          -  Systemic medication or oral steroids within past 3 months (includes light therapy),

          -  Started new atopic dermatitis treatment regimen within the past month,

          -  Using wet/dry wraps > once/week
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 6 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.

Eligibility criteria:
Inclusion Criteria:

          -  18 years old and over

          -  Written consent.

          -  For DIOS Group : at least one criteria of the metabolic syndrome as defined by the
             International Diabetes Federation, associated with hepatic iron overload measured by
             MRI (at least 50 µmol/g) or by hepatic biopsy.

          -  For Genetic Haemochromatosis type 1 Group: homozygosity mutation C282Y in HFE gene ;
             patients undergoing therapeutic phlebotomies.

        Exclusion Criteria:

          -  Persons under guardianship

          -  Body-weight less than 45 kg

          -  Hemoglobin less than 9 g/dL.

          -  Intestinal malabsorption of any cause

          -  Current use or previous use during the last 2 months of iron supplement.

          -  Current use or previous use during the last 2 months of treatment interacting with
             iron absorption (increasing like C vitamin or decreasing like iron chelators)

          -  Other causes of hyperferritinemia : chronic inflammatory syndrome, porphyria,
             hyperferritinemia-cataract-syndrome, chronic alcohol consumption, chronic hemolysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters

Eligibility criteria:
Inclusion Criteria:

        non-smoker

          -  no history of pulmonary disease

          -  absence of dyspnoea, cough, thoracic pain

          -  no self-reported smoking history

          -  normal lung function testing

               -  normal shape of flow-volume curve

               -  normal shape of flow-pressure curve

               -  FEV1/FVC >70% (forced expiratory volume in 1 second / forced vital capacity)

               -  TLC > 80% of predicted (total lung capacity)

               -  TLCO/VA > 80% of predicted (transfer factor corrected for ventilated alveolar
                  volume)

               -  R5 < 150% of predicted (resistance at 5Hz, impulse oscillometry)

        smoker

        - as above, but with self-reported smoking history >10 pack years

        Exclusion Criteria:

          -  unwilling or unable to give informed consent

          -  history of any respiratory disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  All the patients received vertebroplasty treatment between 2005.01-2011.12 with 2nd
             fracture in the vertebral column.

        Exclusion Criteria:

          -  No image available
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effects of Whole Body Vibration (WBV) on Musculoskeletal System of Aged Women

Eligibility criteria:
Inclusion Criteria:

          -  Be sedentary (less than 2 hours physical activity of low intensity per week)

          -  Fracture risk Densitometry Risk factors (FRAX) index between 3 and 10%

          -  Consent form signed

        Exclusion Criteria:

          -  Bone concomitant disease (such as Paget's disease, osteomalacia),

          -  Endocrinopathy defined on biological criteria (such as Cushing's disease,
             hyperparathyroidism, hyperthyroidism, hypogonadism),

          -  Smoking habits (more than 5 cigarettes per day), chronic alcoholism,

          -  Treatments received in the previous 6 months affecting bone metabolism such as
             anabolics, anti-osteoporotic treatment, corticosteroids.

          -  Having a prosthesis (femur and knee),or recently placed metal bouts or plates

          -  acute thrombotic problems,

          -  severe heart- and vascular diseases,

          -  recent injuries due to operation or polyclinical intervention,

          -  acute hernia, discopathy, spondylolysis,

          -  epilepsy,

          -  severe migraine,

          -  pacemaker,

          -  every neurodegenerative or neuromuscular disease,

          -  dementia
Female
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Efficacy, Pharmacokinetics and Safety of Testosterone

Eligibility criteria:
Inclusion Criteria:

          -  Ages 18-65

          -  History of hypogonadism

          -  In good health based on medical history, physical examination and clinical laboratory
             tests

          -  Screening morning serum testosterone ≤ 297 ng/dL

          -  One or more symptoms of testosterone deficiency (i.e. fatigue, reduced libido or
             reduced sexual functioning of non-vasculogenic or neurogenic nature)

          -  Body mass index (BMI) between 18 and 31

        Exclusion Criteria:

          -  Prostate cancer

          -  Palpable prostatic mass(es)

          -  Generalized skin irritation or significant skin disease

          -  Use of any medications that could be considered anabolic (e.g. dehydroepiandrosterone
             (DHEA)) or could interfere with androgen metabolism (e.g. spironolactone, finasteride,
             ketoconazole)

          -  Clinically significant anemia or renal dysfunction

          -  Hyperparathyroidism or uncontrolled diabetes

          -  Serum PSA Levels; ≥ 4ng/mL

          -  History of cardiovascular disease

          -  Use of estrogens, Gonadotropin-releasing hormone (GnRH) agonists/antagonist, human
             growth hormone (hGH), (within previous 12 months)

          -  Use of testosterone products (within eight months for parenteral products, or six
             weeks for other preparations)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: An RCT to Compare the Outcomes of Patients With Large Rotator Cuff Repair That Undergo Repair With or Without SIS

Eligibility criteria:
Inclusion Criteria:

        Patients with large rotator cuff tears (Type 1B or Type 2) determined by clinical
        examination and diagnostic imaging. Criteria described by Harryman et al (1991) will guide
        the classification of rotator cuff tears defined and reassessed at the time of surgery
        (Type 0 = intact cuff, Type 1A = thinned cuff or partial thickness defect, Type 1B= full
        thickness defect on one tendon, Type 2 = full thickness defect of two tendons, Type 3 =
        full thickness defect of three tendons).

        Exclusion Criteria:

          -  Previous shoulder surgery, excluding acromioplasty or diagnostic arthroscopy.

          -  Inability of the surgeon to repair the tear with remaining defect no greater than 10mm
             in diameter,

          -  Inability of the surgeon to repair the tear with less than 1cm of medialization,

          -  Evidence of other significant shoulder pathology including, Type II-IV SLAP lesion,
             Bankart lesion, Hill Sachs lesion, Grade III osteoarthritis).

          -  Active joint or systemic infection,

          -  Significant muscle paralysis of the shoulder girdle,

          -  Major medical illness that would preclude undergoing surgery,

          -  Patients who are unwilling or unable to be assessed according to study protocol for
             one year following surgery

          -  Major psychiatric illness, developmental handicap or inability to read and understand
             the English language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  chronic primary or secondary adrenal insufficiency requiring glucocorticoid
             substitution therapy

        Exclusion Criteria:

          -  adrenocortical carcinoma

          -  long term glucocorticoid treatment above 7.5 mg prednisone equivalent dose for other
             reasons than adrenal insufficiency

          -  age < 18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Effect of Chewing Gum on Small Bowel Transit Time

Eligibility criteria:
Inclusion Criteria:

          -  All out-patients > 19 years old presenting for capsule endoscopy

        Exclusion Criteria:

          -  Patients on narcotics

          -  Patients on motility enhancing and/or slowing drugs should stop these at least 5 days
             prior to the procedure or be excluded from the study.

          -  Patients, who have proven or suspected obstruction of the bowel.

          -  Patients, who have had prior small bowel and/or gastric surgery.

          -  Patients with an ileostomy.

          -  Patients who have a known and/or have a history of swallowing disorder

          -  Patients with diabetes and/or hypo-/hyper- thyroidism

          -  Patients in whom the capsule become impacted at a stricture (these patients will be
             taken out of the study and given the necessary medical/surgical treatment).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment