Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Malignant pleural effusion confirmed by cytologic analysis of the fluid and/or pleural
             biopsy.

          -  Recurrent and symptomatic malignant pleural effusion.

          -  Full pulmonary expansion (>90%) post thoracocentesis, confirmed via chest x-ray.

          -  Karnofsky Performance Status >30

          -  Agreement to participate of the study by signing of the Informed Consent Term.

        Exclusion Criteria:

          -  Coagulopathies (prothrombin activity <50%) and/or thrombocytopenia (<80000 count).

          -  Active pleural or systemic infection.

          -  Massive skin neoplastic infiltration.

          -  Inability of understanding the pain scale.

          -  Previous pleural procedures (except for thoracocentesis and/or pleural biopsy).

          -  Refusal to participate of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Comparing Vision Tests in a Virtual Reality Headset to Existing Analogues

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients of any race who are at least 18 years of age and can
             understand and provide verbal and written informed consent are eligible for this
             study.

        Exclusion Criteria:

          -  Patients who have had intraocular surgery less than six months ago,

          -  Potential contraindication for visual field test that include anxiety disorder,
             pregnancy, seizure disorder,cardiac pacemaker or another implantable device, severe
             vertigo or balance issues.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparison of Postoperative Pain After Hernial Sac Ligation Versus Non-ligation in Inguinal Hernioplasty

Eligibility criteria:
Inclusion Criteria:

          -  Patients ≥15 years of age, of either gender having Incomplete indirect inguinal hernia
             with or without direct concurrent hernia as mentioned in operational definition.

        Exclusion Criteria:

          -  Complete inguinal hernias.

          -  Patients having obstructed and/or strangulated inguinal hernia.

          -  Recurrent inguinal hernias.

          -  patients with ipsilateral synchronous inguinoscrotal pathologies e.g. hydrocele,
             testicular malignancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Development of Novel, Biophysically Designed Fluids for Swallowing Disorders

Eligibility criteria:
Inclusion Criteria:

          -  55 years of age or older

          -  physician approval of medical stability

          -  aspiration or penetration of the laryngeal vestibule (score of 3 or higher on the
             Penetration/Aspiration Scale) or post-swallow residue in the oropharynx as
             instrumentally documented by a Speech-Language Pathologist (SLP) during a standard
             videofluoroscopic oropharyngeal swallow study

          -  capacity to provide informed consent.

        Exclusion Criteria:

          -  poorly controlled psychosis (3 or more related hospitalizations in one year

          -  refractory alcoholism (on AWD precautions)

          -  allergy to barium (used in radiographic swallowing assessment)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of laboratory-supported probable, probable, or definite ALS

          -  Vital capacity of at least 75% of predicted

          -  Onset of weakness within 3 years prior to enrollment

          -  If patients are on riluzole, they must be on a stable dose for at least 30 days prior
             to baseline visit

          -  Women of childbearing potential must be surgically sterile or using an effective
             method of birth control and have a negative pregnancy test

          -  Willing and able to give informed consent

        Exclusion Criteria:

          -  Diagnosis of other neurodegenerative disease

          -  Need tracheotomy ventilation or non-invasive ventilation 23 or more hours/day

          -  Clinically significant history of any unstable medical condition in past 30 days

          -  History of renal

          -  History of liver disease

          -  Current pregnancy or lactation

          -  Use of lithium within thirty days of enrollment

          -  Significantly limited mental capacity

          -  History of recent drug or alcohol abuse

          -  Use of any investigational drug within 30 days prior to enrollment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study

Eligibility criteria:
Inclusion Criteria:

          -  Age between 18 and 35 years (inclusive), in good general health and requesting
             contraception.

          -  Has regular menstrual cycles (length of cycle 21-35 days) (i.e., endogenous cyclicity
             without hormonal contraceptive use).

        Exclusion Criteria:

          -  Known or suspected pregnancy or is lactating.

          -  History of ectopic pregnancies.

          -  Any genital infection (until successfully treated).

          -  Abnormal uterine bleeding of unknown origin.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 1

Eligibility criteria:
Inclusion Criteria:

          -  Must be a current primary care clinic patient

        Exclusion Criteria:

          -  Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Evaluation of Momentary Affect Regulation - Safer Sex Intervention

Eligibility criteria:
Inclusion Criteria:

          -  Be an active patient of one of the participating Planned Parenthood health centers

          -  Own a smartphone

          -  Be fluent in English

          -  Be 17 to 20 years of age

          -  Be biologically able to become pregnant (to the best of their knowledge)

          -  Score at least 10 on the PHQ-8

          -  Have had penile-vaginal sex in the past 3 months

          -  Have had penile-vaginal sex at least once a week, on average

          -  Report having done at least one of the following during the 3 months preceding
             eligibility screening: 1) Not using a condom every time they have sexual intercourse;
             2) Used condoms, a diaphragm, cervical cap, spermicide, sponge, fertility awareness,
             or withdrawal as a primary form of birth control; 3) Had sexual intercourse with more
             than one person; 4) Had sexual intercourse within 2 hours after using drugs and
             alcohol; and/or 5) Been treated for an STI/STD

        Exclusion Criteria:

          -  Trying to get pregnant or currently pregnant at the time of eligibility screening

          -  Have given birth during the 6 months preceding eligibility screening

          -  Married or engaged to be married at the time of eligibility screening
Female
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2020_09

Eligibility criteria:
Inclusion Criteria:

          -  Healthy outer ear (without previous surgical procedures)

          -  Ability to fill in a questionnaire conscientiously

          -  Informed Consent as documented by signature

          -  Minimum 1 year hearing aid experience

          -  Moderate-Severe (N3-N5) hearing loss or Normal Hearing

        Exclusion Criteria:

          -  Contraindications to the MD in this study, e.g. known hypersensitivity or allergy to
             the investigational product

          -  Limited mobility and not in the position to attend weekly appointments

          -  Inability to produce a reliable hearing test result

          -  Massively limited dexterity

          -  Known psychological problems

          -  Known central hearing disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19, Aging, and Cardiometabolic Risk Factors Study

Eligibility criteria:
Inclusion Criteria:

          -  Patients newly diagnosed with COVID-19 at hospital setting or community screening,
             confirmed with biological proof (RT-PCR)

        Exclusion Criteria:

          -  Subjects opposed to the use of their data

          -  Minors, adults under guardianship, protected persons

          -  History of malignancy

          -  History of autoimmune disease

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan

Eligibility criteria:
Inclusion Criteria:

          1. A diagnosis in accordance with Criteria for the Diagnosis of Primary Osteoporosis.

          2. Other inclusion criteria as specified in the study protocol.

        Exclusion Criteria:

          1. Patients having secondary osteoporosis or another condition that presents low bone
             mass.

          2. Patients having findings that affect measurement of lumbar spinal bone mineral density
             by DXA

          3. Patients that have been administered bisphosphonate derivatives.

          4. Other exclusion criteria as specified in the study protocol.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment