Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Ability to produce semen sample

        Exclusion Criteria:

          -  Cognitive impairment

          -  Inadequate language skills for informed consent
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: PREPARE-IBD: Physician Responses to Disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease During COVID-19 Pandemic

Eligibility criteria:
Inclusion Criteria:

          -  Patients with IBD +/- flare +/- COVID 19 positivity

        Exclusion Criteria:

          -  Patients below 16

          -  Patient with inactive IBD
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Validation of Wrist Type Oscillometric Blood Pressure Monitorings

Eligibility criteria:
Inclusion Criteria:

          -  above 12 years old

        Exclusion Criteria:

          -  unclear Korotkoff sounds

          -  wrist circumference outside of the designated range (13.5-23 cm)

          -  arrhythmias
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Position of EGD in Droplet Spreading

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have the indication for upper gastrointestinal endoscopy

        Exclusion Criteria:

          -  Cannot be in prone position

          -  The endoscopist deny the assigned position in any reason.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Randomized Multicentre Study Comparing TEP With Lichtenstein Repair for Primary Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  Age 30-70 years referred to hospital with a primary inguinal hernia.

        Exclusion Criteria:

          -  Recurrent hernia

          -  Scrotal or bilateral hernia

          -  Previous lower abdominal surgery

          -  Unable to participate in follow up

          -  ASA more than 3

          -  Bleeding diathesis.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Development and Testing of a Jamaican Mother-daughter HIV Risk-reduction Program

Eligibility criteria:
Inclusion Criteria:

        Inclusion criteria for the adolescent include:

          -  age between 13- to 17-years, inclusive

          -  resident of one of the three parishes in and around Kingston, Jamaica (the study area)

          -  plan to reside in the "study area" for the next 12 months

          -  able to read, write and understand English

          -  unmarried and

          -  agrees to participate and

          -  mother or primary female guardian also agrees to participate.

        Inclusion criteria for the mother/female guardian include:

          -  age greater than 18

          -  resident of one of the three parishes in and around Kingston, Jamaica (the study area)

          -  plan to reside in the "study area" for the next 12 months

          -  able to read, write and understand English and

          -  agrees to participate

        Exclusion Criteria:

          -  adolescent and/or mother who is/are disruptive and/or otherwise unable to participate
             in small group intervention activities

          -  adolescent who is married
Female
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases

Eligibility criteria:
Inclusion Criteria:

          -  aged 18 years and older

          -  patients diagnosed with amyotrophic lateral sclerosis or other neurodegenerative
             disease, and healthy controls

        Exclusion Criteria:

          -  Subjects with acute bacterial infection of the GI tract

          -  Subjects on treatments with antibiotics or probiotics within 28 days prior to sampling
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: A New Treatment Option for Heavy Menstrual Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 18-50 years having regular menstrual cycles

          -  Women willing to collect all sanitary protection for 6 cycles

          -  Women with no contraindications to use of combined hormonal contraception

          -  Women not using any hormonal contraception or any treatment for HMB

          -  Women who have no demonstrable uterine pathology on pelvic ultrasound

          -  Women who have demonstrated a menstrual blood loss (MBL) >80mls in 2 of 3 menstrual
             periods during the pre-treatment phase will be eligible to enter the treatment phase

        Exclusion Criteria:

          -  Women for whom combined oral contraceptives are contraindicated

          -  Women unwilling to collect all sanitary protection for 6 cycles

          -  Women using hormonal contraception or any treatment for HMB

          -  Women who have demonstrable uterine pathology on pelvic ultrasound

          -  Women who have demonstrated a MBL ≤80mls in 2 of 3 consecutive menstrual periods
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Clinical Trial of Hysteroscopy in Postmenopausal Women to Compare Techniques

Eligibility criteria:
Inclusion Criteria:

          -  Women post-menopausal with abnormal uterine bleeding, ultrasound with thick
             endometrial distorted

        Exclusion Criteria:

          -  Women with uterine malformations

          -  Women with mental retardation

          -  Women underwent pelvic radiotherapy
Female
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Prevalence and Predictors of Osteoporosis in the Beijing's Urban Population

Eligibility criteria:
Inclusion Criteria:

          -  20 to 79 residents in urban Beijing, China.

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children

Eligibility criteria:
Inclusion Criteria:

          -  short stature children aged 2 years or more

          -  children with GHD,TS, CRF, SGA or ISS

          -  written informed consent from the person, person's parent or legal guardian
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Human Cell Line-derived Recombinant Factor VIII (Human-cl-rhFVIII) in Previously Untreated Patients

Eligibility criteria:
Inclusion Criteria:

          -  Male patients

          -  Severe Hemophilia A (FVIII:C <1%)

          -  No previous treatment with FVIII concentrates or other blood products containing FVIII

        Exclusion Criteria:

          -  Diagnosis with a coagulation disorder other than Hemophilia A

          -  Severe liver or kidney disease

          -  Concomitant treatment with any systemic immunosuppressive drug
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment