Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles

Eligibility criteria:
Inclusion Criteria:

          -  women with poor ovarian response candidate for ICSI

          -  women with spontaneous normal menstrual cycle

          -  normal uterine cavity

        Exclusion Criteria:

          -  women with ovarian cysts

          -  endometriosis

          -  hydrosalpinx

          -  endocrinological disorders as hyperprolactinemia, thyroid or adrenal disorders.

          -  Couples with azospermic male partner

          -  those with severe uncontrolled medical or metabolic disorders
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Chinese Tuina Therapy for Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of KOA;

          2. Age 40-75 years;

          3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 3 months;

          4. NRS score of pain at least more than 4 points;

          5. Single/bilateral knee pain, duration of more than 6 month; If the patient has KOA on
             both legs, the heavier leg is selected for study.

        Exclusion Criteria:

          1. Surgery history of knee or waiting for surgery (knee replacement or knee arthroscopy);

          2. Knee pain caused by other diseases (such as joint bodies, severe effusion of joint
             cavity, infection, malignant tumors, autoimmune diseases, trauma, etc.);

          3. Oral administration of hormones within 3 month, intra-articular injection within 6
             months, knee injuries or open injuries within 6 months, or knee arthroscopy within 1
             year.

          4. Severe acute/chronic organic or mental diseases;

          5. Pregnant women, pregnant and lactating women;

          6. Coagulation disorders (such as hemophilia, etc.), or the skin diseases at the site of
             operation;

          7. Device support treatment after knee osteoarthritis disability;

          8. Participation in another clinical study in the past 3 months;

          9. History of receiving acupuncture, massage, manipulation, or any medical plaster
             treatment within 3 months

         10. Breaks for treatment longer than 3-4 weeks depending on each circumstance or merit may
             be construed as non-compliance and may be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

Eligibility criteria:
Inclusion Criteria:

          -  Female volunteers in early to mid-puberty (i.e., late Tanner I [estradiol level > 20
             pg/mL], Tanner II, or Tanner III)

          -  Premenarcheal

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin less than 12 g/dl and hematocrit less than 36%

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism, reflected by persistently abnormal
             thyroid-stimulating hormone (TSH) values

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-hydroxyprogesterone > 200 ng/ml (in girls without a previous
             diagnosis of congenital adrenal hyperplasia)

          -  Dehydroepiandrosterone sulfate (DHEA-S) > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 26 kg.
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Comparative Study of LAVH and Minilaparotomy Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Non descent uterus with benign gynaecological conditions

        Exclusion Criteria:

          -  Uterine size > 20 weeks

          -  Minilaparotomy was contraindicated in patients where severe adhesions might exist eg -

               -  Endometriosis

               -  Previous pelvic inflammatory disease

          -  Patients with one or more contraindications for LAVH were excluded -

               -  Cardiac or respiratory morbidity contraindicating laparoscopy

               -  Frozen pelvis

               -  Cervix flushed with vagina
Female




Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Relationship Between Skeletal Muscle Mass and Interventricular Septum Thickness in Apparently Healthy Overweight and Obese Subjects

Eligibility criteria:
Inclusion Criteria:

          -  Overweight or obesity (BMI> 25 Kg/m2)

        Exclusion Criteria:

          -  Any kind of drug

          -  Hypertension

          -  Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism,
             etc.),

          -  Chronic inflammatory diseases

          -  Renal failure

          -  Liver failure

          -  Angina pectoris

          -  Myocardial infarction and heart failure

          -  Genetic heart diseases

          -  Thrombocytopenias
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with Amyotrophic lateral sclerosis (ALS)

        Exclusion Criteria:

          -  Late stage ALS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Endoscopic Management of Esophageal Wall Defects

Eligibility criteria:
Inclusion Criteria:

          -  Any patient with spontaneous or iatrogenic esophageal wall defect

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Proof of Concept (Bone Resorption/Bone Mineral Density) Study (0429-005)

Eligibility criteria:
Inclusion Criteria:

          -  Person is a women with osteoporosis who is unwilling or unable to take other
             treatments for osteoporosis

        Exclusion Criteria:

          -  Person has had a previous fracture

          -  Person has rheumatoid arthritis. Person has has certain types of cancer

          -  Person has donated blood or has been in another investigational study within the last
             4 weeks
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Biomarker for Duchenne Muscular Dystrophy

Eligibility criteria:
INCLUSION CRITERIA

          -  Informed consent is obtained from the parent/ legal guardian

          -  The participant is aged between 2 months and 50 years

          -  The diagnosis of DMD is genetically confirmed by CENTOGENE

        EXCLUSION CRITERIA

          -  Informed consent is not obtained from the parent/ legal guardian.

          -  The participant is younger than 2 months or older than 50 years

          -  The diagnosis of DMD is not genetically confirmed by CENTOGENE
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Months old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effects of a Moisturizing Product on Dry Eye and Skin

Eligibility criteria:
Inclusion Criteria:

          -  Dry eye symptoms OSDI score 20 or higher

          -  Dryness, burning or foreign body sensation moderate or higher

        Exclusion Criteria:

          -  Severe eye diseases

          -  Known allergy to any of the ingredients of the product

          -  Laser surgery of eyes during the last year
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction