Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: ICSI Versus Conventional IVF in Non-male Factor Couples

Eligibility criteria:
Inclusion Criteria:

          -  Having ≤ 2 IVF/ICSI cycles

          -  Total sperm count and motility are normal (WHO, 2010)

          -  Antagonist protocol

          -  Agree to have ≤ 2 embryos transferred

          -  Not participating in another IVF study at the same time

        Exclusion Criteria:

          -  In-vitro maturation (IVM) cycles

          -  Using frozen semen

          -  Poor fertilization in previous cycle (≤ 25%)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Health and Cancer Issues in the South Asian Community

Eligibility criteria:
Inclusion Criteria:

          1. Self identified South Asian (Asian Indian, Bangladeshi, Pakistani, Sri Lankan)
             residents of Harris, Fort Bend, Brazoria and Galveston counties.

          2. 18 years of age or older

          3. Those who speak the languages (including English) that had been identified as most
             frequently used in Houston's South Asian community by the Community Advisory
             Committee.

        Exclusion Criteria:

          1. None

          2. Sri Lankans who participated in Protocol 2006-1047.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Lung Disease Collection (Qatar): Evaluation of the Lungs of Individuals With Lung Disease

Eligibility criteria:
Inclusion Criteria:

        Inclusion/Exclusion criteria for Part A

          -  Must provide informed consent

          -  Males and females, age 18 years and older

          -  Evidence of lung disease by at least one of the following:

               1. symptoms consistent with pulmonary disease;

               2. chest X-rays and/or chest CT consistent with lung disease;

               3. pulmonary function tests consistent with lung disease;

               4. lung biopsy consistent with lung disease;

               5. family history of lung disease;

               6. diseases of organs with known association with lung disease; and

               7. individuals suspected of having lung disease based on history and/or physical
                  examination

          -  Undergoing fiberoptic bronchoscopy as dictated by their standard clinical care

        Exclusion Criteria:

          -  Patient refuses consent.

        Patients enrolled in Part A of the protocol will not undergo screening procedures/tests.
        These patients are undergoing a fiberoptic bronchoscopy as dictated by their standard
        clinical care and additional samples will be taken for research purposes.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Can 3D Laparoscopy Improve Surgical Performances in Surgeons in Training?

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from benign uterine pathology (uterine fibromatosis, abnormal blood
             loss, complex hyperplasia with atypia, uterine prolapse) with indication for total
             uterine hysterectomy

          -  Uterine size </= than 15 cm

          -  American Society of Anesthesiologists (ASA) class < 3

          -  Patient's informed consent

          -  No actual pregnancies or pelvic inflammatory disease

          -  No previous major abdominal surgical procedures

        Exclusion Criteria:

          -  Suspected neoplastic pathology

          -  Patients not eligible for surgery
Female




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders

Eligibility criteria:
Inclusion Criteria:Clinical diagnosis of Menorrhagia

          -  Must be able to swallow tablets

        Exclusion Criteria:

          -  Endometrial abnormality

          -  Pelvic infection

          -  Pregnancy

          -  Breast Feeding

          -  Requirement for birth control

          -  Known intolerance/lack of effect of tranexamic acid
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Family SuppleMented pAtient monitoRing afTEr suRgery: A Pilot Trial

Eligibility criteria:
Inclusion Criteria:

        Patients:

        • Patients ≥5 years of age undergoing surgery at Mbale Regional Referral Hospital, who
        receive post-operative care in one of four main surgical wards, with a family carer
        prepared to participate in the trial intervention.

        Carers:

          -  All carers will be included in the trial if they feel they are capable of performing
             and documenting the basic vital signs provided they agree to participate in the trial.

          -  The ability to speak English, Luganda, Lugisu, Ateso or Lugwere

          -  The ability to read a digital clock (to measure vital signs)

          -  Numeracy sufficient to write numbers on the basic observation chart

        Exclusion Criteria:

        Patients:

          -  Refusal of informed consent.

          -  Identification of potential participant >24hours after operative procedure has taken
             place

        Carers:

        • Refusal of informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: BFRT for Severe Lower Extremity Muscle Atrophy

Eligibility criteria:
Inclusion Criteria:

          -  Patients with > 20% deficit in isometric quadriceps and/or hamstrings strength

          -  Patients willing to complete at least 9 BFRT training sessions

          -  Patients willing to provide informed consent (or parental consent)

        Exclusion Criteria:

          -  Pregnancy

          -  History of varicose veins

          -  History of blood clots or active blood clot

          -  Taking oral contraceptives

          -  History of heart attack

          -  Unstable cardiac disease

          -  Taking heart failure medication

          -  Uncontrolled hypertension (> 140/90)

          -  Uncontrolled tachycardia (> 100 bpm)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Clinical Protocol of Sensitized Acupoint Changes in Knee Osteoarthritis Patients

Eligibility criteria:
Inclusion Criteria:

        Meets the diagnosis criteria of knee osteoarthritis. Age between 45 and 70 years. Meets
        imaging examination X-ray Kellgren and Laerence classification standards grade I-III.

        Patients who meet the criteria for early or mid-term stage of knee osteoarthritis.

        Discontinue use of pain medications and hormone drugs during the trial. The patient's vital
        signs are stable, can read his own medical history, and can cooperate with the relevant
        examination and treatment.

        Signed the informed consent voluntarily.

        Exclusion Criteria:

        Seriously patients with surgical indications Associated systemic arthropathies, e.g.
        rheumatoid arthritis and gout Heart failure Bleeding diathesis Liver failure knee
        arthroplasty There are diseases that may seriously endanger life, such as cardiovascular
        and cerebrovascular diseases, renal and liver failure, hematopoietic system diseases, etc.

        Patients with mental illnesses that cannot be completed or are not suitable for treatment
        and examination Patients who received treatment including traditional Chinese medicine,
        western medicine, acupuncture, massage and physiotherapy within the past month Patients on
        steroids History of intra articular injection of steroid within last six months Joint
        irrigation or arthroscopy has been performed within the past year Have had knee
        arthroplasty At the same time participate in other studies
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 38 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants

Eligibility criteria:
Inclusion Criteria:

          -  Mother-infant pairs, between 35 weeks and 41 completed weeks of pregnancy, planned to
             deliver through vaginal or Elective lower segment cesarean section(ELSCS)

        Exclusion Criteria:

          -  Women with multiple gestation

          -  Complications like pregnancy induced hypertension (PIH), Gestational diabetes Mellitus
             (GDM), Pre/Eclampsia, placental insufficiency, suboptimal CTG (late deceleration,
             variable deceleration)

          -  Rh-isoimmunization

          -  Chronic maternal illnesses (hypertension, cardiomyopathies, chronic renal diseases,
             haemoglobinopathies

          -  Pre-existing risk factor for postpartum haemorrhage, like polyhydramnios, previous PPH

          -  Infants with antenatal diagnosis of congenital malformations of any system (CVS, GIT,
             RENAL CNS ,RESP), anomalies or syndromes

          -  Emergency caesarean section (EmLSCS)

          -  Need for neonatal resuscitation at birth and NICU admission due to causes not directly
             related to the intervention trial.

        Criteria 1 to 6 will be applied before randomization and criteria 7 and 8 assess after
        randomization.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 3 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial

Eligibility criteria:
Inclusion Criteria:

          -  mild to moderate sensorineural hearing loss

          -  tinnitus (THI > 20)

          -  first user

        Exclusion Criteria:

          -  profound hearing loss

          -  conductive hearing loss

          -  THI < 20
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment