Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          1. Males or Females 40 years and older

          2. According to the clinical diagnosis standard of the American College of Rheumatology
             (ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
             over 3 conditions of followings.

               -  Over 50 years of age

               -  Less than 30 minutes of morning stiffness

               -  Crepitus on active motion

               -  4 bony tenderness

               -  Bony enlargement

               -  Nopalpable warmth of synvium

          3. Within 6 months from screening visit, someone who diagnosed with Kellgren & Lawrence
             Grade I~III by the radioactive examination.

          4. By the Weight-bearing pain(100mm-VAS) examination, someone who has a outcome of the
             single or both sides of the osteoarthritis is over 40mm

          5. Patient (No-responder) who has experienced steady pain in spite of dosing NSAIDs or
             other pain-killers in the past.

          6. Patient who can walk by themselves without helper like cane or walker etc. (If the
             patient who has used helper routinely from previous 6 months, evaluating the patient
             including the helper is possible. In this case, patient needs to use same helper
             continuously by end of the clinical trial test.)

          7. Patient who agrees to participate in this clinical trial by themselves.

        Exclusion Criteria:

          1. Someone who has BMI≥32kg/m² at the screening visit.

          2. Patient who has an experience dosing psychoactive drug, narcotic analgesic which can
             have an effect on pain sense over 3 months habitually.

          3. Patient who has been administrated gastrointestinal drug(for example H₂-blockers,
             misoprostol or proton pump inhibitors) regularly, who can't stop injecting for
             clinical study period.

          4. Patient has attended abnormal values from screening test(2 times excess at upper limit
             of the normal values at ALT, AST, BUN, Serum Creatinine).

          5. Patient who has rheumarthritis or other inflammatory metabolic arthritis.

          6. Patients having serious gastrointestinal, liver, renal, heart disease.

          7. When the inflammatory disease is occurred on joint area to patient like septic
             arthritis.

          8. Patients having skin ailment at the injecting site of the joint region.

          9. Patients having secondary osteoarthritis according to the Ochronosis, Hemochromatosis
             or systemic disease.

         10. Patients who have severe pain like Sudek's atrophy, Paget's disease, Spinal disc
             herniation.

         11. Poly-articular patients who have suffered seriously by osteoarthritis at other parts
             affect judge of the knee joint pain.

         12. Patients who diagnosed clear interval disappearance at the knee joint by X-ray.

         13. Patients who were administrated below drugs before baseline visit.

               -  Patients who were injected HA at the target knee joint in recent 9 months.

               -  Patients who were injected HA at other parts of the knee joint in recent 6
                  months.

               -  Patients who were injected steroids into the intra-articular knee joint.

               -  Patients who were administrated steroids systemically by the oral medication
                  (But, except inhalation)

         14. Patients who have joint effusion trouble were judged as a positive by tests like
             Patella tap test.

         15. Patients who have target knee joint gotten surgical operation history including
             Arthroscopy within past one year (In case of having other side of knee joint or hip
             joint gotten surgical operation history, excepting the patients if there is
             possibility which can influence the target knee joint's appraisal.

         16. Patients who have an operation history about target knee joint.

         17. Patients who do the height weight aerobic exercise or anaerobic exercise.

         18. Patients who need to be administrated anticoagulant agent together(But, except 300mg
             daily dose aspirin)

         19. Patients who have hypersensitivity history about Investigational Product.

         20. In the midst of women in their childbearing years, patients who disagree to do *
             contraception by medically permitted method for 12 weeks from administrating
             investigational product.

             * The contraception by medically permitted method: Condom, In case of using injection
             or insertion, In case of installing a intrauterine contraception device etc.

         21. Patients who were injected other investigational product over a time within 30 days
             before participated in this clinical trail.

         22. Besides that, the patients who have difficulty to be participated in this clinical
             trial continuously by Principle Investigator (PI)'s decision.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment