Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Healthy Teen Girls: HIV Risk Reduction

Eligibility criteria:
Inclusion Criteria:

          -  Female, ages 13 to 17 years, committed to Columbia Training School, who provide
             written informed assent.

        Exclusion Criteria:

          -  Acute or chronic physically illness that would preclude participation as determined by
             facility physician; placement in maximum security unit; study participation during a
             prior commitment
Female
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: The Genetic Characterization of Dementia

Eligibility criteria:
-  INCLUSION CRITERIA:

        Previous diagnosis of Dementia by neurologist, other medical care provider, or researcher
        accompanied by sufficient clinical and/or laboratory evidence

        Clinical confirmation of Dementia by the investigator and his associates either by exam
        and/or review of medical records

        Family member of diagnosed dementia patient

        Healthy controls

        EXCLUSION CRITERIA:

        Individuals with any movement disorder secondary to a specific environmental exposure,
        birth injury, metabolic disorder, or brain infection such as encephalitis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Interest of Cardiac Computed Tomography to Optimize and Improve the Procedure of TAVI

Eligibility criteria:
Inclusion Criteria:

          -  Patient with a symptomatic severe aortic stenosis with a too high risk of surgical
             valvular replacement. This patient will be selected for a TAVI. In this study, we only
             randomized patient for a TAVI with an Edwards prosthesis

          -  male or female patient, older than eighteen years old

          -  who have given their written consent

          -  who are affiliated to the French social security system

          -  which has a too high risk of surgical valvular replacement (EuroSCORE logistic > 20%
             or Society of Thoracic Surgeons Score > 10, or contre indicated to a cardiac surgery
             by a heart team

          -  Severe Aortic stenosis with symptoms like dyspnea, heartache, syncope, heart failure

        Exclusion Criteria:

          -  Patient who can't give his written consent because of his physical or mental status

          -  Adult patient protect by law (article L1121-8),

          -  Person deprived of liberty (article L1121-8),

          -  Pregnant women

          -  Patient in terminal phase of illness,

          -  Terminal kidney failure

          -  Allergy to iodine

          -  bicuspids ou unicuspid aortic,

          -  Diameter of the left ventricular outflow tract < 18mm or > 25mm,

          -  Diameter of the femoral artery < 7mm, tortuosity or calcifications

          -  Septal hypertrophy

          -  Apical thrombosis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparative Study Between ICSI Results in Transvaginal Ultrasound Guided Embryo Transfer and Transabdominal Ultrasound Guided Embryo Transfer

Eligibility criteria:
Inclusion Criteria:

          -  Infertile female patients aged 20-37 years old undergoing IVF

          -  Long protocol

          -  Embryo transfer of fresh cycles D3

        Exclusion Criteria:

          -  Uterine abnormalities e.g. sub-mucous fibroid, or fibroids indenting the endometrium,
             polyps, Ashermann, etc.

          -  Poor responders

          -  Female patients ˃35 years old

          -  Medical disorders e.g. DM, HTN

          -  Immunological disorders e.g. SLE, APS

          -  Cervical distortions

          -  Thyroid or adrenal dysfunction

          -  Endometriosis grade 3 or 4
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Plasma Total Antioxidant Status and Thiobarbituric Acid-reacting Substances in Patients With Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with inguinal hernia.

        Exclusion Criteria:

          -  Patients with acute disease and severe chronic disorder.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children

Eligibility criteria:
Inclusion Criteria:

          -  Group1: Children with GH deficiency diagnosed by 2 provocative tests with peak GH less
             than 10 ng/ml.

          -  Group 2:Children with height less than the 3rd centile without any etiology

          -  Group 3:children with failure to thrive until the age of 3 years.

          -  Group 4: children with obesity defined by BMI above the 90th centile for age and sex.

          -  Group 5: children with no endocrine diseases and without obesity or short stature.

        Exclusion Criteria:

          -  Children with known pediatric or endocrine diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Norwegian Adenomyosis Study I

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women aged 30 - 50 years old

          -  scheduled for vaginal, abdominal or laparoscopic total hysterectomy

          -  one or more of the following clinical symptoms: bleeding disorders (menorrhagia,
             irregular bleeding, hypermenorrhoea), chronic pelvic pain, dysmenorrhoea, or
             dyspareunia

          -  junction zone definable

        Exclusion Criteria:

          -  postmenopausal women,

          -  pregnancy

          -  gynecological cancer

          -  GnRH analog therapy or systemic hormone therapy in the last three months prior to
             hysterectomy

          -  junctional zone not identifiable
Female
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Sonography and Haemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (≥ 18 years of age) suffering from severe haemophilia A or B

          -  No professional medical background

          -  Submitted written consent to participate in the study and to use their study related
             pseudonymized data

        Exclusion Criteria:

          -  Patients suffering from other bleeding diseases

          -  Participants < 18 years of age

          -  Participants without written consent

          -  Professional medical background
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Efficacy of Pancrelipase on Postprandial Belching and Bloating.

Eligibility criteria:
Inclusion Criteria:

          -  Subjects will have either bothersome upper abdominal discomfort, bloating (feeling of
             abdominal distention) or belching following meals for at least 12 month's duration.
             Subjects must have had a normal upper gastrointestinal endoscopy and/or upper GI
             series during the preceding three years.

        Exclusion Criteria:

          -  Individuals with a history suggestive of organic disease such as recent weight loss,
             nausea, vomiting, GERD, recent changes in bowel habits will be excluded from the
             study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Implications for Quality of Life and Quality of Care in Patients With Hereditary Haemochromatosis

Eligibility criteria:
Inclusion Criteria:

          -  phase 1: experts in the field of haemochromatosis (hepatologists, hematologists,
             endocrinologists, general practitioner, nurses, ...)

          -  phase 2: patients with hereditary haemochromatosis, treatment with phlebotomy since 3
             months, Dutch/English speaking

        Exclusion Criteria:

          -  patients with secundary iron overload

          -  phlebotomy treatment less than 3 months

          -  language: no Dutch or English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: German Pediatric Hemophilia Research Database

Eligibility criteria:
Inclusion Criteria:

          -  hemophilia A or B

          -  FVIII/FIX <1% to 25%

          -  informed consent

        Exclusion Criteria:

          -  no consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment