Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Role of Lymphocyte Subsets and Laboratory Measurements in COVID-19 Disease

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of COVID-19 disease.

        Exclusion Criteria:

          -  The patients were excluded patients <18 years age and without confirmed diagnosis of
             disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: LTFU for Gene Transfer Subjects With Hemophilia B

Eligibility criteria:
Inclusion Criteria

        -Adult subjects who participated in prior intrahepatic AAV2-hFIX16 gene transfer studies

        Exclusion Criteria

          -  Subjects who will not consent for study

          -  Subjects who the investigators believe are not capable of performing endpoints of the
             study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis

Eligibility criteria:
Inclusion Criteria: • 40-60 years of age paients will be included in this study

          -  BMI (25.1±4.2) kg/m2

          -  Subjects with stiffness and knee pain

          -  Subjects with objection of pain in knee joint that was aggravated by performing 2 or
             more of the following functional activities: prolonged cross sitting, stair assents
             and descent, squatting and kneeling.

          -  Subjects who are willing to take participation

          -  Individuals who obeys the commands properly

          -  Individuals exhibiting the subsequent biomechanical changes on screening

          -  Q angle >12 degree for male and >15 degree for female, femoral anteversion, external
             tibial torsion >15 degree, lack of ≥ 5 degree of knee extension in supine position.

        Exclusion Criteria:

          -  • Knee meniscal injuries or ligament injuries

               -  Lately history of lower limb trauma and surgery

               -  In recent times fracture in lower extremity

               -  In lower extremity metal plantation

               -  Cardio vascular conditions

               -  Patella Dislocation/subluxation

               -  Abnormality in foot or deformity
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.

Eligibility criteria:
Inclusion Criteria:

          -  Infertile women who were indicated for IUI cycles

          -  bilateral tubal patency

          -  at least one follicle ≥ 18mm in diameter on the day of trigger, and

          -  men with more than five millions total motile sperm after preparation.

          -  Only the first cycles of IUI were studied

        Exclusion Criteria:

          -  No mature follicle

          -  Disagree to be enrolled
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Sustainable Method for Alzheimer's Prediction

Eligibility criteria:
Exclusion criteria for AD will be:

          -  frontotemporal dementia;

          -  behavioural variant of frontotemporal dementia;

          -  vascular dementia;

          -  extra-pyramidal syndromes;

          -  reversible dementias (including pseudodementia of depression);

          -  Lewy body dementia.

        The exclusion criteria for aMCI will be:

          -  mild AD, as diagnosed by standard protocols including National Institute on
             Aging-Alzheimer's Association workgroups (McKhann et al. 2011);

          -  evidence (including magnetic resonance imaging -MRI procedures) of concomitant
             dementia such as frontotemporal, vascular and reversible dementias (including
             pseudo-depressive dementia), marked fluctuations in cognitive performance compatible
             with Lewy body dementia and/or features of mixed dementias;

          -  evidence of concomitant extrapyramidal symptoms;

          -  clinical and indirect evidence of depression as revealed by the Geriatric Depression
             Scale GDS (Yesavage et al. 1982); scores lower than 14 (no depression);

          -  other psychiatric diseases, epilepsy, drug addiction, alcohol dependence, use of
             neuro/psychoactive drugs including acetylcholinesterase inhibitors;

          -  current or previous uncontrolled or complicated systemic diseases (including diabetes
             mellitus) or traumatic brain injuries.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination

Eligibility criteria:
Inclusion Criteria:

          -  Patients with unexplained infertility

          -  Age between 18 - 37 years

          -  Period of infertility > 1 year

          -  Patent Fallopian tubes detected by hysterosalpingography and/or laparoscopy

          -  Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and
             prolactin concentrations

          -  Normal recent semen analysis (according to World Health Organization criteria)

        Exclusion Criteria:

          -  FSH> 10 IU/L

          -  Irregular menstrual cycles

          -  Polycystic ovary syndrome

          -  Endometriosis

          -  Endocrinologic disorders

          -  Systemic disease contraindicating pregnancy

          -  Previous IUI cycles

          -  liver or kidney diseases
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate in Lateral Epicondylitis (Tennis Elbow)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with clinical diagnosis of tennis elbow within the last 3 months

          -  Subjects both male and female, aged 18-60 years (both inclusive)

          -  Subjects who are willing to give informed consent and adhere to the study protocol

        Exclusion Criteria:

          -  Subjects aged less than 18 and more than 60 years

          -  Subjects with autoimmune diseases

          -  Subjects with immuno-compromised system

          -  Subjects on Anti-coagulant therapy or blood thinning medicines like Aspirin

          -  Subjects taking concomitant therapy that might interfere with the study results in
             investigators opinion or who had concomitant other injury of the tennis elbow tendons.

          -  Subjects who have received treatment with corticosteroid injections within the last 6
             months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

        PTPs:

          -  Males of any age who have been diagnosed with severe congenital hemophilia A (FVIII
             activity levels < 1%) and who participated in a previous CSL-sponsored clinical study
             with rVIII-SingleChain.

          -  Males 0 to <65 years age who have been diagnosed with severe congenital hemophilia A
             (FVIII activity levels < 1%), who have at least 50 EDs to any FVIII product, and who
             are not currently enrolled in a CSL-sponsored clinical study with rVIII-SingleChain.

        PUPs:

          -  Males 0 to <18 years of who have been diagnosed with severe congenital hemophilia A
             (FVIII activity levels < 1%)

          -  No prior exposure to any Factor VIII product (with the exception of short-term use of
             blood products).

        ITI substudy:

          -  PUPs who have developed a confirmed inhibitor to rVIII-SingleChain in the main study.

        Exclusion Criteria:

          -  Known or suspected hypersensitivity to rVIII-SingleChain or to any excipients of
             rVIII-SingleChain or Chinese hamster ovary (CHO) proteins.

          -  Currently receiving a therapy not permitted during the study.

          -  Serum creatinine > 2 x upper limit of normal, alanine aminotransferase or aspartate
             aminotransferase > 5 x upper limit of normal at Screening (if specified)

          -  Any first-order family (eg, siblings) history of FVIII inhibitors

          -  For PTPs not rolling over directly from a CSL-sponsored clinical study with
             rVIII-SingleChain: any history of or current FVIII inhibitors
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between CYP2C9 Inhibitor and Substrate

Eligibility criteria:
1. Men and women, aged 18 to 50 years. Women of non-childbearing potential may be
             included.

          2. Body mass index in the range of 18 to 30 kg/meter squared and body weight equal to or
             greater than 50 kg.

          3. Healthy as determined by the investigator on the basis of medical history, physical
             examination, clinical laboratory test results, vital signs, and 12 lead
             electrocardiogram (graphic trace of the pattern of your heart beat).

          4. Non-smoker or smoker of fewer than 10 cigarettes (half a pack) per day as determined
             by history. Must abstain from smoking during inpatient stay.

          5. Have a high probability for compliance with and completion of the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation

Eligibility criteria:
Inclusion Criteria:

        i) osteopenic postmenopausal Caucasian women following Dmab treatment ii) assignment to
        treatment with alendronate in an effervescent tablet formulation following Dmab
        discontinuation

        Exclusion Criteria:

        i) secondary osteoporosis; ii) diseases that could affect bone metabolism iii) medications
        that could affect bone metabolism iv) chronic kidney disease (stage >3b) and/or liver
        failure v) neoplastic disease vi) hypersensitivity to alendronate or to any of the
        excipients vii) abnormalities of the esophagus and other factors which delay esophageal
        emptying such as stricture or achalasia viii) inability to stand or sit upright for at
        least 30 minutes ix) hypocalcaemia x) confirmed esophagitis
Female


Subject must be at most 90 Years

Eligibility (NLI label): Contradiction