Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye

Eligibility criteria:
Inclusion Criteria:

        Ocular foreign body sensation, burning or stinging, complaints more pronounced in winter,
        windy conditions, during computer work, being bilateral, of the duration longer than three
        months, visual acuity fluctuations depending on blinking after longer reading or computer
        work, and tearing in cold weather, in the morning, after longer reading or computer work.
        Patients were also asked whether the symptoms were more pronounced in the morning or
        evening. The main enrollment criterion was the score of the above listed symptoms 15 or
        higher.

        Exclusion Criteria:

        Pregnant women, children, chronic eye patients on continuous topical therapy during
        previous month (i.e.glaucoma) and patients suffering from any acute eye disease and
        therefore on topical or systemic therapy in the previous month were excluded from the
        study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patient admitted for rectal biopsy, by clinical decision, so that Hirschsprungs
             disease may be diagnosed or ruled out

        Exclusion Criteria:

        None

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  5-17 years of age, has a diagnosis of Hemophilia A or B.

        Exclusion Criteria:

          -  Muscle or joint bleed within 4 weeks of study.

          -  Pre-existing co-morbidities that would affect physical activity participation.

          -  Unable to cooperate with study protocol.

          -  Unable to speak, read, or understand English.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study Comparing Blood Levels of ReFacto and Advante in Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A

          -  Previously treated patients with at least 150 exposure days to any Factor VIII product

        Exclusion Criteria:

          -  Hypersensitivity to any recombinant Factor VIII product

          -  History of or current Factor VIII inhibitor

          -  Bleeding episode or other reason requiring Factor VIII treatment within 3 days of
             study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Randomized Fracture Liaison Services

Eligibility criteria:
Inclusion criteria：

          -  Age>=50

          -  New hip fracture from orthopedic ward

          -  Newly identified vertebral fracture (either morphological or clinical)/ old hip
             fracture without osteoporosis treatment referred by team physicians either inpatients
             or outpatients

          -  Willing to accept 10 years of follow-ups.

        Exclusion criteria

          -  Traumatic or pathologic fractures

          -  Atypical femoral shaft fracture

          -  Participating in other medication intervention trials

          -  Less than 2 years of life expectancy judged by team physicians

          -  Incapable of accepting evaluation for cognitive, communication, and physical problems
             judged by team physicians or coordinators.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Patients undergoing investigation or treatment for thoracic cancers with
             oncogene-targeted therapies

          2. Aged 18 years or older

          3. Either a) have suspected tumor progression or other condition that dictates a
             standard-of-care palliative, therapeutic, or diagnostic intervention including but not
             limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or
             ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS)
             pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor
             specimen appropriate molecular analysis or b) have previously had biopsy/surgical
             intervention with tumor tissue at University of Colorado or an outside institution
             available for medullar analysis.

          4. Patients must have the ability to understand and willingness to sign an informed
             consent document.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female between the ages of 18 and 85 with clinical diagnosis of ALS

          -  Forced Vital Capacity (FVC) > 60% of predicted

          -  Less than 3 years of ALS since the onset of the first symptom with clinical evidence
             of limb muscle atrophy and weakness.

          -  Subjects taking Riluzole must have been at a stable dose for at least 30 days with no
             evidence of toxicity

          -  Female of childbearing potential and male of child-creating potential must agree to
             use a medically acceptable physical barrier (condom, diaphragm, and cervical cap)
             through the treatment phase and for at least 30 days after the last study treatment.

        Exclusion Criteria:

          -  Women who are pregnant or currently breast-feeding

          -  Dependent upon invasive or non-invasive artificial ventilation

          -  Patients with bulbar onset ALS or with other active neuromuscular/ neurodegenerative
             diseases.

          -  Type 1 or Type 2 diabetes.

          -  Evidence of chronic or active heart, liver, kidney, or lung diseases, or Age-related
             macular degeneration.

          -  Current or history of known immune or immunodeficiency disorders

          -  Patients with cognitive impairment with significant decision making incapacity, or
             major depression, or schizophrenia, or dementia (e.g. Alzheimer's disease).

          -  Malignancy or history of malignancy, except it has been in complete remission for at
             least 5 years

          -  Pre-cancerous conditions (e.g. Barrett's Esophagus, dysplasias) or benign tumors which
             have the potential for significant growth due to VEGF stimulation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: A Multi-site Trial Comparing Lichtensteins Operation and Prolene Hernia System in Inguinal HErnia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Primary unilateral groin hernia in adult

        Exclusion Criteria:

          -  recurrence warfarin treatment bilateral groin hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Real-time fMRI Neurofeedback in Patients With MCI

Eligibility criteria:
Inclusion Criteria:

          -  Intact activities of daily living

          -  Fluent in German

          -  Normal/corrected-to-normal vision

          -  Written informed consent

        Exclusion Criteria:

          -  Dementia

          -  Current/lifetime severe psychiatric or neurological disorder

          -  History of seizures

          -  Psychotropic medication

          -  Currently/lifetime drug or alcohol abuse

          -  Brain damage

          -  Magnetisable implants
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Testing a Body-functionality Intervention for Body Image in Individuals With Skin Conditions

Eligibility criteria:
Inclusion Criteria:

          -  Individuals with dermatological condition (including conditions that affect the skin,
             hair and/or nails). This includes, but is not limited to, acne, eczema, alopecia,
             psoriasis, vitiligo, rosacea, dermatitis, hyperpigmentation, hidradenitis suppurativa
             (HS), hyperhidrosis, hirsutism, neurofibromatosis, onychomycosis, melasma, cysts,
             herpes, ichthyosis, and lichen sclerosus.

          -  Individuals self-reporting that their body image is affected by their skin condition.

          -  Sufficient English to complete the measures and writing exercises

          -  Access to the internet.

        Exclusion Criteria:

          -  As the focus of this research is on skin disease, individuals living with visible
             differences as a consequence of trauma (e.g. scarring from burns or scarring from
             traumatic injury) are not eligible to participate in this study.

          -  Individuals who do not feel their body image is affected by having a dermatological
             condition.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment