Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle

Eligibility criteria:
INCLUSION CRITERIA:

        Children of either gender, aged 4 to 18 years.

        Obstructive HCM defined as LV hypertrophy, and an LV intra-cavitary pressure gradient
        measured at cardiac catheterization of greater than or equal to 30 mm Hg at rest or greater
        than or equal to 50 mm Hg following isoproterenol infusion to a heart rate of greater than
        or equal to 100 beats per minute.

        Cardiac symptoms (chest discomfort, dyspnea, lightheadedness or presyncope, syncope,
        cardio-respiratory arrest, palpitations, excessive fatigue); and/or exercise duration which
        is less than 10th percentile predicted for age/gender despite a trial of a beta-blocker
        therapy and a trial of verapamil therapy.

        EXCLUSION CRITERIA:

        Other systemic diseases that prevent assessment by exercise tests and cardiac
        catheterization.

        Chronic atrial fibrillation.

        Positive pregnancy test: A negative urine pregnancy test will be required before each
        cardiac catheterization, electrophysiologic study and thallium study. Pregnant or lactating
        subjects may not participate in the study due to potential teratogenic effects of
        radiation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Cyriax Manipulation in Lumbar Derangement Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  lumber pain, pain radiating to leg, motor deficits in legs, , dural signs and
             symptoms, impaired nerve root mobility(straight leg raise and L3 stretch), back pain
             effecting Quality of life, ODI score less than 30 and Limited range of motion .

        Exclusion Criteria:

          -  Osteoporosis of hip, Bilateral sciatica, having anticoagulant medication, pregnancy,
             patient with impaired mental status
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Correlation Analysis of Hearing Thresholds, Validated Questionnaires and Psychoacoustic Measurements in Tinnitus Patients

Eligibility criteria:
Inclusion Criteria:

          -  tinnitus for more than 6 months

          -  sensorineural hearing loss

          -  normal otoscopy

        Exclusion Criteria:

          -  conductive or mixed hearing losses

          -  A-r, A-d, B and C tympanograms

          -  tinnitus treatment in the last 6 months

          -  pregnant woman

          -  Vestibular Schwannoma
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Efficacy and Safety Study of XP12B in Women With Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occurring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that may
             confound the study

          -  History of bilateral oophorectomy or hysterectomy

          -  Hormone therapy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Pain Nurse Led Package of CareTrial

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain on most days of the previous month

          -  At least moderate pain on two of the five WOMAC knee pain domains in the most painful
             knee

          -  Knee pain present for longer than 3 months

        Exclusion Criteria:• House-bound or care home resident

          -  Dementia

          -  Dialysis

          -  On home oxygen

          -  Serious mental illness

          -  Inability to communicate in English

          -  Unable to give consent

          -  Terminal cancer

          -  Known diagnosis of autoimmune rheumatic diseases or psoriasis

          -  Knee or hip replacement, or on waiting list for knee or hip replacement

          -  Asthma or COPD requiring regular daily oral corticosteroids

          -  Unstable angina or heart failure

          -  Known peripheral vascular disease

          -  Pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Safety and Efficacy of IQP-LH-101 in Postprandial Heartburn

Eligibility criteria:
Inclusion Criteria:

          -  Post-prandial heartburn (e.g. after a high-fat meal) in at least 2 months prior to the
             study (at least 2 times a week)

          -  Not receiving prescribed treatment for heartburn, reflux or upper gastrointestinal
             disorders

          -  Written informed consent is a prerequisite for subject enrollment.

        Exclusion Criteria:

          -  Gastrointestinal bleeding within 12 months prior to the study

          -  Difficulty swallowing (dysphagia)

          -  History of or symptoms suggestive of Zollinger-Ellison syndrome, oesophageal or
             gastric malignancy, gastric or duodenal ulcer, pernicious anaemia, Barrett's
             oesophagus or systemic sclerosis

          -  Participation in other studies within the last 30 days prior to entry or during the
             study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Talc in Treating Patients With Malignant Pleural Effusion

Eligibility criteria:
DISEASE CHARACTERISTICS: Unilateral malignant pleural effusion requiring sclerosis (as
        judged by the attending surgeon) At least 3 months since treatment of contralateral
        effusion No chylous effusion

        PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
        More than 2 months Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
        Other: Able to undergo thoracoscopy under general or local anesthesia (as determined by the
        attending surgeon) Not pregnant Tests and observations must be completed within 1 week
        prior to randomization (chest x-ray within 1 week prior to procedure)

        PRIOR CONCURRENT THERAPY: No prior intrapleural therapy No systemic therapy within 2 weeks
        prior to randomization or 2 weeks post pleurodesis Biologic therapy: Not specified
        Chemotherapy: No new systemic chemotherapy for 2 weeks prior to and at least 2 weeks after
        pleurodesis Endocrine therapy: No new hormonal therapy for 2 weeks prior to and at least 2
        weeks after pleurodesis No concurrent steroids used as antiemetics Radiotherapy: Prior
        radiotherapy allowed No radiotherapy to entire hemithorax Palliative irradiation of
        symptomatic bone lesions allowed on the affected side if field does not include a
        significant portion of pleura Surgery: See Disease Characteristics
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 120 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Issues Surrounding Prenatal Genetic Testing for Achondroplasia

Eligibility criteria:
Adult individuals of either gender with achondroplasia and their first degree relatives
        (both short and average statured) of all ethnic and cultural backgrounds.

        No short-statured persons with conditions other than achondroplasia.

        No average-statured family members of short statured persons with conditions other than
        achondroplasia.

        No minors less than 18 years of age.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. Patients with Sjögren's syndrome (Revised Japanese criteria for Sjögren's syndrome
             (1999): 1998 research report on immunological intractable diseases specified by the
             Japanese Ministry of Health and Welfare)

          2. Patients aged 20 years or older at time of consent

          3. Patients with dry mouth

          4. Patients with decreased salivation

        Exclusion Criteria:

          1. Patients who have developed dry mouth clearly due to a cause other than Sjögren's
             syndrome

          2. Patients in whom Saxon test cannot be performed (artificial tooth, tooth implant,
             etc.)

          3. Patients who have received rebamipide within 3 months prior to obtaining informed
             consent

          4. Patients who are pregnant, possibly pregnant, or lactating

          5. Patients with a history of hypersensitivity to rebamipide

          6. Patients who have received any other investigational drug within 3 months prior to
             obtaining informed consent

          7. Patients who are otherwise judged inappropriate for inclusion in the study by the
             investigator or subinvestigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment