Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Tissue Removal During Hysterectomy: The Effect of Vaginal Versus Abdominal Morcellation on Surgical Outcomes

Eligibility criteria:
Inclusion Criteria:

          -  Hysterectomy planned for a benign gynecologic reason

          -  Patient is scheduled to have surgery with one of the minimally invasive gynecologic
             surgeons at George Washington University Hospital. (Dr. Moawad, Dr. Marfori, or Dr.
             Vargas)

          -  Patient is planned for a robotic assisted total laparoscopic hysterectomy (RA-TLH) or
             a total laparoscopic hysterectomy (TLH)

          -  Patient is capable of informed consent

          -  Patient must be between 18 and 65 years of age

          -  Uterus greater than 12 centimeters in height and 4 centimeters in width or 12 weeks in
             size

        Exclusion Criteria:

          -  Hysterectomy is indicated for malignancy

          -  Procedure is anything other than RA-TLH or TLH

          -  Surgeon is not one of hte minimally invasive surgeons at GWUH

          -  Surgery is scheduled for a hospital other than GWUH

          -  Patient does not meet the age requirements.

          -  Patient is not capable of informed consent

          -  Uterus is less than 12 cm in heightand 4 cm in width
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Molecular and Clinical Profile of Von Willebrand Disease in Spain

Eligibility criteria:
Inclusion Criteria: One or more of the following:

          1. VWF ≤ 30 IU/d, in 2 or more occasions.

          2. Presence of multimeric abnormalities.

          3. If isolated FVIII deficiency demonstration of decreased FVIII binding.

          4. Presence of some VWF mutation.

          5. ↑ RIPA at low concentrations of ristocetin.

        Exclusion Criteria:

          1. Presence of any data suggesting AVWS.

          2. Absence of a signed patient informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Ultrasound Estimation of Pleural Effusion in the Sitting Patients

Eligibility criteria:
Inclusion Criteria:

          -  Monolateral or Bilateral Pleural Effusion (any cause)

          -  Able to achieve a sitting position

          -  Chest CT scan within 24 hours available

          -  Informed consent available

        Exclusion Criteria:

          -  No informed consent available

          -  Age under 18

          -  No recent Chest CT scan available

          -  Unable to keep the sitting position
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Cytokine Storm Among Bangladeshi Patients With COVID-19

Eligibility criteria:
Inclusion Criteria:

          1. Adults aged ≥18 years,

          2. Informed consent obtained for participation,

          3. A mild, moderate or severe (±critical cases) RT-PCR confirmed COVID-19 cases,

          4. RT-PCR negative healthy volunteers.

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Treatment of Lateral Elbow Tendinopathy

Eligibility criteria:
Inclusion Criteria:

          1. Pain around the lateral part of the elbow joint for more than 4 weeks.

          2. Pain on palpation of the proximal part of the common extensor tendon.

          3. Pain reproduced with resisted dorsiflexion of the wrist.

          4. Dash score > 30.

          5. Ultrasonographic appearance consistent with lateral elbow tendinopathy (irregular
             appearance of the tendon, hypo-/hyper-echoic changes, pathological doppler signal,
             increased tendon thickness).

        Exclusion Criteria:

          -  American Society of Anesthesiologists (ASA) > 2 (mild systemic disease).

          -  Patients with symptoms consistent with differential diagnoses such as:

               -  referred pain,

               -  radiohumeral synovitis and bursitis,

               -  posterior interosseous nerve entrapment (radial tunnel syndrome),

               -  osteoarthritis of the elbow, and

               -  prior injections or acupuncture around the elbow joint within the last 6 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

Eligibility criteria:
DISEASE CHARACTERISTICS: Histologically proven newly diagnosed moderate or high grade
        osteosarcoma without metastases No prior treatment, including complete resection No
        parosteal or periosteal sarcoma No osteosarcoma associated with Paget's disease No
        nonresectable tumors or tumors that may result in marginal or interlesion resection Must be
        enrolled on protocol POG-9851

        PATIENT CHARACTERISTICS: Age: 30 and under Performance status: ECOG 0-2 Life expectancy:
        Not specified Hematopoietic: Absolute neutrophil count at least 1,000/mm3 Platelet count at
        least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times normal SGOT no greater than
        3 times normal Renal: Creatinine normal Phosphate at least 3.0 mg/dL without
        supplementation Cardiovascular: Shortening fraction at least 28% by echocardiogram If
        echocardiogram unsatisfactory, must have ejection fraction at least 50% No history of
        pericarditis or myocarditis No symptomatic arrhythmia or symptomatic cardiac conduction
        disturbances

        PRIOR CONCURRENT THERAPY: See Disease Characteristics Biologic therapy: Not specified
        Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior
        radiotherapy Surgery: See Disease Characteristics
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 30 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients

Eligibility criteria:
Inclusion Criteria:

          1. Subjects (his/her parent/legal representative), must have given a written informed
             consent.

          2. Male children: age <12 years.

          3. Severe or moderate Haemophilia A (FVIII <2%).

          4. High responders (clinical history of inhibitor peak > 5BU) or low-responders (clinical
             history of inhibitor peak < 5 BU) with potential bleedings, assessed by responsible
             physicians as not to be treated with high FVIII doses.

          5. Any level of inhibitor at study enrollment.

          6. Willingness and ability to participate in the study.

          7. No other experimental treatments (involving or not FVIII concentrates).

        Exclusion Criteria:

          1. Any clinically relevant abnormality, in hematological, biochemical and urinary routine
             examinations, or any condition or treatment which in the investigator's opinion, makes
             the patient not eligible for the study.

          2. Intolerance to active substances or to any of the excipients of FVIII / VWF
             concentrates.

          3. Concomitant systemic treatment with immunosuppressive drugs.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: The Efficacy of Using Far Infrared Radiation to Manage Muscular Dystrophies

Eligibility criteria:
Inclusion Criteria:

          -  Persons with muscular dystrophies

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Comparison of Zenker's Diverticulum Treatment Using Peroral Endoscopic Myotomy and Flexible Endoscopy Septotomy.

Eligibility criteria:
Inclusion Criteria:

          1. Males and females who are 18 years of age and older and are able to comprehend
             instructions and follow the study procedures and are willing to sign an Informed
             Consent Form (ICF).

          2. Patients with symptomatic Zenker's Diverticulum.

          3. Confirmed diagnosis of Zenker's Diverticulum based on endoscopic and radiological
             examinations.

          4. Size of Zenker's Diverticulum in the range of 1,5 to 4 cm on radiological
             examinations.

        Exclusion Criteria:

          1. Lack of written consent for participation in the study.

          2. Size of Zenker's Diverticulum <1,5 cm or >4 cm on radiological examination.

          3. Active cancer.

          4. Esophageal stricture.

          5. Eosinophilic esophagitis (EoE).

          6. Pre-cancerous changes in the esophagus.

          7. Previous surgical or endoscopic treatment of Zenker's Diverticulum.

          8. Presence of chewing deficiencies and/or neurogenic dysphagia.

          9. Presence of other esophageal motility disorders e.g. achalasia and/or spastic motility
             disorders.

         10. Severe systemic diseases which are contraindication to general sedation.

         11. Severe coagulopathy.

         12. Pregnancy and breastfeeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis

Eligibility criteria:
Inclusion Criteria:

          -  18 to 80 years of age

          -  male and female

          -  hypothalamic pituitary disorders (study subjects)

          -  history of regular, age appropriate menses (control subjects)

          -  male subjects with normal serum testosterone and follicle stimulating hormone (FSH)
             (control subjects)

          -  normal FSH in post-menopausal subjects (control subjects)

          -  normal thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin (control
             subjects)

        Exclusion Criteria:

          -  unable to give consent

          -  pregnancy

          -  active acromegaly

          -  pheochromocytoma

          -  active Cushing's disease

          -  pituitary insult within past 6 weeks

          -  elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST)

          -  renal failure

          -  history of malignancy

          -  severe acute illness

          -  uncontrolled hypertension

          -  Diabetes mellitus (DM) type 1

          -  Hemoglobin (Hgb) A1c >9% in last 3 months in Type 2 DM

          -  severe coronary artery disease

          -  women <50 years of age with untreated hypogonadism

          -  men with untreated hypogonadism

          -  growth hormone treatment in the past 3 months
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment