Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Neuromuscular Control in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Knee osteoarthritis participants only:

          -  Knee Osteoarthritis confirmed by a physician using the American College of
             Rheumatology (ACR 1986) Criteria

          -  Have unilateral or bilateral knee osteoarthritis

          -  Aged 40 years or over.

        Healthy control participants only:

          -  Have no history of unilateral/bilateral knee osteoarthritis

          -  Had no current chronic/stable knee pain in the past 3 months

          -  Aged 40 years or over.

        Exclusion Criteria:

        All participants are excluded if they:

          -  Have neuromuscular skeletal injury/illness (e.g.Multiple Sclerosis, Parkinson's
             disease, Muscular Dystrophy, Cerebral Palsy)

          -  Have had knee surgery, knee arthroplastic surgery and arthroscopic debridement or
             corrective surgery for knee osteoarthritis in the past 12 months

          -  Have had corticosteroid injections to or around the knee in the past 3 months.

          -  Have unstable heart disease

          -  Previously had a stroke

          -  Have insulin-dependent diabetes

          -  Have osteoporosis

          -  Have a history of falls and other motor deficits

          -  Are unable to walk up and down stairs

          -  Are unable to rise from a chair without the aid of another person

          -  Have an unstable medication schedule and medication that causes dizziness

          -  Have Dementia/Alzheimer's/ an inability to comprehend, follow instructions and give
             informed consent

          -  Have an inability to lie flat for 60 minutes Have mental in their body.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment