Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Effect of Gastrectomy and Anastomosis on Diabetes and Hypertension in Early Gastric Cancer Patients

Eligibility criteria:
Inclusion Criteria:

          -  Histologically proven primary gastric adenocarcinoma

          -  clinical stage Ia or Ib examined with endoscopy, endoscopic ultrasound, and computed
             tomography

          -  aged 20-80 year old,

          -  performance status (PS) of 0 or 1 on Eastern Cooperative Oncology Group (ECOG) scale

          -  diagnosed as diabetes or hypertension

          -  patients planning to undergo gastrectomy or endoscopic submucosal dissection

          -  written informed consent

        Exclusion Criteria:

          -  having high risk for operation such as severe heart disease, severe respiratory
             disease

          -  pregnant

          -  previous abdominal surgery or radiation therapy

          -  proven more advanced disease than pathological stage II requiring adjuvant
             chemotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B

Eligibility criteria:
Inclusion Criteria:

          -  Moderate or mild hemophilia A (FVIII:C 0.02-0.35 IU/mL) or hemophilia B (FIX:C
             0.02-0.35 IU/mL)

          -  Age from 12 up to and including 55 years

        Exclusion Criteria:

          -  Other clotting disorder

          -  Participation in another trial with an investigational product

          -  Comorbidity affecting the musculoskeletal status

          -  Clinically relevant inhibitor status at present or in the past

          -  Hemophilia B Leyden

          -  Use of anticoagulants
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS)

Eligibility criteria:
Inclusion Criteria:

          -  Women affected by adenomyosis with pelvic pain > 4;

          -  Negative Pap Smear test

        Exclusion Criteria:

          -  Pregnancy or research of pregnancy

          -  Refusal or inability to sign informed consent

          -  Severe underlying comorbidities (hepatic, oncological)

          -  Pelvic inflammatory disease

          -  Other cervical or uterine pathologies

          -  Deep venous thromboembolism

          -  Hormonal therapy contraindications

          -  Smoke
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Staging Procedures to Diagnose Malignant Pleural Mesothelioma

Eligibility criteria:
Inclusion Criteria:

          -  Subject provides informed consent

          -  Subject is >18 years of age

          -  Subject is deemed competent for making medical decisions

          -  Subject is scheduled to undergo a staging pleuroscopy

          -  Subject is a surgical candidate

          -  A negative pregnancy test is required in women of child-bearing potential, as standard
             of care.

        Exclusion Criteria:

          -  Subject is <18 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging

Eligibility criteria:
Inclusion Criteria:

          -  Age: over 65

          -  Participants (or representatives) gave their written informed consent

          -  Dementia diagnosed according to Diagnostic and Statistical Manual of Mental Disorders
             (DSM IV) criteria

          -  For Alzheimer arm: probable Alzheimer based disease according to NINCDS-ADRDA
             (National Institute of Neurological and Communicative Disorders and Stroke and the
             Alzheimer's Disease and Related Disorders Association ) criteria

          -  For vascular dementia: diagnosis based on NINDS-AIREN (National Institute of
             Neurological Disorders and Stroke and Association Internationale pour la Recherche et
             l'Enseignement en Neurosciences) criteria

          -  For MCI: diagnosis based on Petersen index

        Exclusion Criteria:

          -  Claustrophobia

          -  Diabetes

          -  Cardiovascular disease

          -  Glycemia over 1.3 g/L

          -  Lumbar puncture within one week before MRI examination

          -  Non MR-compatible implant

          -  Suspected brain metastases

          -  No informed consent signature
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Multistability: Perception is Inspired by Noise

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Medical examination carried out before the participation in the research

          -  Age between 18 and 55 years

          -  Minimum level of studies

          -  Obligation to join the social security system

          -  normal or corrected vision normal

        Exclusion Criteria:

          -  Subject included in another clinical and / or therapeutic experimentation in progress

          -  Major vision disorder

          -  Past or current neurological or neuropsychiatric pathologies

          -  History of cranial trauma with loss of consciousness.

          -  Medication treatments likely to modulate brain activity: benzodiazepine,
             antidepressants, neuroleptics, lithium, etc.

          -  Diabetes, cardiac pathology, immunodeficiency.

          -  Medication treatments likely to modulate the activity of the cardiovascular system.

          -  History of abuse or recent ingestion of alcohol, hard drugs or doping products.

          -  Consumption of more than 15 cigarettes per day

          -  Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)

          -  Major subject subject to a legal protection measure or unable to express their consent
             (L1121-8 CSP)

          -  Pregnant, parturient and nursing mothers (L1121-5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Weight Loss for Obese Individuals With Gout

Eligibility criteria:
Inclusion Criteria:

          -  a diagnosis of gouty arthritis per expert opinion and the ACR/EULAR 2015 criteria for
             gout.

          -  have had at least one self-reported flare in the last 12 months

          -  BMI >30kg/m2

          -  >18 years of age

        Exclusion Criteria:

          -  pregnant

          -  hisotry or suspicion of drug abuse within the past 5 years

          -  Active muscle disease, cancer, previous kidney disease, and/or fatty liver

          -  An estimated creatinine clearance <30 mL/min calculated by the Cockcroft-Gault formula
             using ideal body weight.

          -  An investigational therapy within 8 weeks or 5 half-lives (whichever is longer) prior
             to the screening visit.

          -  Any other medical or psychological condition which, in the opinion of the investigator
             and/or medical monitor, might create undue risk to the patient or interfere with the
             patient's ability to comply with the protocol requirements, or to complete the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Safety and Efficacy of AFQ056 in Adult Patients With Fragile X Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Fragile X Syndrome, who are at least moderately ill based on a Clinical
             Global Impression Severity score of at least 4 and have qualifying scores on the ABC-C
             and IQ test at Visit 1

        Exclusion Criteria:

          -  Advanced, severe or unstable disease that may interfere with the study outcome
             evaluations

          -  Cancer within the past 5 years, other than localized skin cancer

          -  Current treatment with more than two psychoactive medications, excluding
             anti-epileptics

          -  History of severe self-injurious behavior

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Alzheimer's disease or Mild Cognitive Impairment

          -  must be able to swallow pills

        Exclusion Criteria:

          -  known or suspected bipolar disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  El Escorial Classification of laboratory supported probable, probable,or definite ALS

          -  Age 18 - 80 years,

          -  ALS symptoms for no more than 3 years,

          -  FVC greater than or equal to 60% predicted,

          -  Riluzole naïve or have been on a stable dose of Riluzole for at least 2 months,

          -  Patients must have the ability to attend monthly study visits in Edmonton or Calgary,
             Alberta

        Exclusion Criteria:

          -  Presence of significant sensory abnormalities, dementia, other neurologic diseases,
             uncompensated medical illness and psychiatric illness

          -  Female patients who are breastfeeding

          -  Use of concurrent investigational drugs,

          -  Patient unlikely to comply with study requirements

          -  Poor adherence to study protocol during run-in phase
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment