Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women 45 years or older. No period for at least two years.

          -  History of back pain that started at least 2 months prior to the initial visit (likely
             due to spinal bone fracture determined by investigator).

          -  Minimum of one moderate spinal bone fracture.

          -  Beginning pain level of at least four on an eleven point scale.

          -  Bone Mineral Density (BMD) must meet criteria

          -  Able to read, understand, and administer self-questionnaires.

          -  Be willing and able to use a pen-injector to deliver the medication.

        Exclusion Criteria:

          -  Are at increased risk for osteosarcoma.

          -  Have an active or suspected diseases that affects bone metabolism other than
             osteoporosis.

          -  Participants that already know that they will require procedures to repair their
             spinal bone fractures.

          -  Abnormal values of certain lab tests.

          -  Anything that would make it difficult to determine if the back pain was due to the
             fracture.

          -  Poor medical or psychiatric condition.

          -  Alcohol or drug abuse within a year of the study start.

          -  Certain malignant neoplasms in the 5 years prior to enrollment.

          -  Active liver disease or clinical jaundice.

          -  Significantly impaired renal function.

          -  History of nephrolithiasis or urolithiasis within 2 years prior to enrollment.

          -  Known contraindication or intolerance to risedronate and/or teriparatide therapy.

          -  Treatment with oral strontium or certain therapeutic doses of fluoride.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Contradiction