Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion

Eligibility criteria:
Inclusion Criteria:

          -  Singleton pregnancy.

          -  14-24 weeks gestation..

          -  Missed miscarriage

        Exclusion Criteria:

          -  History of pulmonary, hepatic, renal, or cardiovascular diseases.

          -  History of previous cesarean section and other uterine surgeries as hysterotomy and
             myomectomy.

          -  Inevitable abortion.

          -  Placenta covering internal os.

          -  History of any cervical surgery as cervical amputation, cauterization or dilatation.

          -  Premature rupture of membranes.

          -  Any vaginal bleeding.

          -  Contraindications for misoprostol as hypersensitivity to misoprostol, chronic adrenal
             insufficiency and inherited porphyrias.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Parkinson's Disease (PD)

          -  Healthy

        Exclusion Criteria:

          -  Subject does not have clinical diagnosis of PD, however, has another neurological
             disorder/disease that manifests with symptoms of tremor or dysphonia

          -  Subject diagnosed with PD does not have dysphonia and tremor
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Development of a Specific Measure for Assessing Adherence in Adult Patients With Hemophilia.

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A or B.

          -  Patients over 18 years of age.

        Exclusion Criteria:

          -  Patients with neurological or cognitive impairments that hinder oral and written
             comprehension.

          -  Patients who have not signed the informed consent document
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Study of the Effects of Muscular Activity on Iron Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  Male individuals aged between 18 and 40 years old

          -  Body mass index (BMI) between 18 and 25

          -  Normal at clinical examination

          -  Normal biological variables

          -  Written informed consent

        Exclusion Criteria:

          -  Mutation C282Y of the HFE gene

          -  Iron metabolism abnormality

          -  Inflammatory syndrome

          -  Chronic pathology or ongoing treatment

          -  Tobacco smoking, alcohol consuming more than 30g/day

          -  History of transfusion or blood-giving within 3 months

          -  Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: ACTIONS - Aortic Counterpulsation to Improve Outcomes in Noncardiac Surgery

Eligibility criteria:
Inclusion Criteria:

          -  Patients > 18 years with planned elective major abdominal, noncardiac thoracic, head
             and neck, vascular, or orthopedic surgery and guideline-treated iscehmic heart disease
             with left ventricular dysfunction (systolic ejection fraction < or = 30%)

        Exclusion Criteria:

          -  Unstable coronary syndromes Decompensated or NYHA Class IV heart failure Hemodynamic
             instability Cardiac biomarker instability Need for surgical procedure interfering with
             placement of IABP Cardiogenic shock Septic shock Contraindication to IABP use Clinical
             need for IABP ASA score > or = 5 Pregnancy Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Anastrozole Administration in Elderly Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  Men ages 60 and older

          -  Serum testosterone between 150-300 ng/dL

          -  Symptoms suggestive of androgen deficiency
Male
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Natural Cycle/Progesterone Fortified Protocol for Endometrial Preparation for Frozen/Thawed Embryo Transfer

Eligibility criteria:
Inclusion Criteria:

          1. Women younger than 39 at the time of cryopreservation

          2. Regular menstrual cycles of at least 26 days and at most 32 days.

          3. Women with no more than 3 failed prior embryo transfers

          4. Patients with embryos cryopreserved 48 hours after ovum pick up

        Exclusion Criteria:

          1. Women with known uterine malformations or significant myomas

          2. Women with elevated Progesterone of at least 1.5 ng/mL for the duration of more than
             72 hours before embryo transfer can be performed

          3. Women suspected of having endometrial pathology based on previous treatment cycles
             i.e. "thin endometrium", polyps, adhesions

          4. Women whose embryos did not survive the thawing process, i.e. no embryos available for
             transfer after thawing

          5. Women without follicular development
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Light and the Effect on Metabolic Syndrome and Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of mild to moderate Alzheimer's disease or related dementia,

          -  type 2 diabetes

          -  sleep disturbance as determined by a score ≥ 5 on the PSQI

        Exclusion Criteria:

          -  insulin-dependent diabetes,

          -  urinary incontinence

          -  obstructing cataracts

          -  macular degeneration

          -  blindness

          -  severe sleep apnea or

          -  restless leg syndrome (RLS)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Movement Visualization in Patients With Hemophilic Arthropathy

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A and B

          -  Medical diagnosis of hemophilic arthropathy

          -  Chronic joint pain

          -  Over 18 years

          -  On prophylactic treatment or on demand with FVIII / FIX concentrates

        Exclusion Criteria:

          -  Patients with neurological or cognitive disorders that impede the understanding of the
             questionnaires

          -  Painless patients

          -  Amputee, epileptic or seriously impaired vision patients

          -  Patients receiving physiotherapy treatment at the time of the study

          -  Patients who have not signed the informed consent document.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Effect of Oral Menthol on the Swallow Response of Patients With Oropharyngeal Dysphagia Associated With Neurological Diseases and Aging

Eligibility criteria:
Inclusion Criteria:

          -  patients with suspicion of OD associated with aging (>70 years), neurodegenerative
             diseases or stroke.

        Exclusion Criteria:

          -  Patients with suspicion that they will not be able to compliment the protocol,
             patients participating or have participated in a clinical study the last 4 weeks and
             patients with alcoholic or drugs dependence
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Abdominal Wall Function and Quality of Life and Before and After Incisional Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Elective laparoscopic repair for one or more incisional hernias in the midline (at
             least 5 cm caudal to the xiphoid process and at least 5 cm cranial to the pubic bone),
             using a synthetic mesh

          -  Horizontal fascial defect between 3 and 8 cm

          -  Age between 25 and 75 years

          -  American Association of Anesthesiologist score between I and III

          -  Body mass index < 33 kg/m^2

        Exclusion Criteria:

          -  Severe musculoskeletal, neurologic or cardiopulmonary disease preventing the patient
             from climbing stairs or shopping for groceries

          -  Existing stoma

          -  Postoperative complications requiring intervention
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment