Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Effect of Needle Size in Diagnostic Yield of EBUS-TBNA in Sarcoidosis and Lymphoma

Eligibility criteria:
Inclusion criteria

          -  Patient t referred for specimens by EBUS -TBNA with clinical and radiological
             suspicion of sarcoidosis or lymphoma , with pathological lymph node on imaging (small
             diameter ≥ 1.0 cm CT-scan or hyper metabolism with PET scan) in para-tracheal
             stations, sub-carinal and / or hilar (stations 2, 4, 7, 10, 11 and 12), right and / or
             left.

          -  Lymph nodes with a small diameter of at least 0.5 cm in CT-scan or PET / CT scan
             performed in the previous 4-6 weeks.

          -  Patient investigated in the setting of either an initial diagnosis or a suspicion of
             lymphoma recurrence (post-treatment).

          -  Patient able to consent to the procedure and to authorize us by written proxy,
             included in the consent form for the study, to obtain a copy of the subsequent results
             or radiological (PET, CT-scan, chest X-ray) or histopathological (linked with age
             sampled of intrathoracic lymph nodes).

          -  Patient deemed fit to tolerate the procedure.

        Exclusion criteria

          -  Patient unable to give consent.

          -  Female patient during pregnancy

          -  Patient aged under 18.

          -  Patient with significant coagulopathy ( INR > 1.5 ; platelet count<50 000 / mm 3 ).

          -  Patient anticoagulated (oral or parenteral) and whose anticoagulation can not be
             suspended for the procedure.

          -  Obvious involvement of organ (s) with the possibility of confirming granulomas or
             suspicious cells of lymphoma by means of a procedure considered less invasive (.. e g,
             lymph node biopsy of cervical, supraclavicular or inguinal nodes; skin biopsy).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction