Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  willing to participate in this clinical study, and signed informed consent

          -  age from 18 to 70 years old,both genders are permitted

          -  diagnosed as the Sjögren syndrome

          -  have the symptoms and signs of dry eye disease as below:

               1. have at least 2 symptoms such as dryness,foreign body sensation ,eye
                  strain,conjunctival congestion,secretion.The summed up score of symptoms greater
                  than 6.

               2. the score of tear-film break up time less than 5 seconds or the score of Schirmer
                  test less than 5mm/5min.

               3. the score of corneal fluorescein staining greater than 3.

                  Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of Respiratory Specimens for Bacterial and Viral Pathogens by Real-Time PCR

Eligibility criteria:
Greater than 18 years of age. Cough present greater than one day and a history of fever and
        chills or documented fever in the Emergency Department
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Desmopressin for Bleeding Related to Low Body Temperature

Eligibility criteria:
Inclusion Criteria:

        1. Healthy volunteers

        Exclusion Criteria:

          1. Any known platelet or coagulation disorder.

          2. Pregnant or lactating women.

          3. Known chronic liver or renal disease.

          4. Coronary artery, carotid artery or peripheral artery disease

          5. Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.

          6. Smoker or alcohol user

          7. Mentally incapable of providing informed consent

          8. Students or junior staff members who had direct working relationship with the PI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome

Eligibility criteria:
Inclusion criteria:

          -  Male and female patients with Cushing syndrome (CS) caused by ACTH-producing pituitary
             adenoma or cortisol producing adrenal adenoma

          -  Age between 18 and 65 years

        Exclusion criteria

          -  CS caused by ectopic ACTH producing tumours

          -  CS caused by adrenocortical carcinoma

          -  Pseudo CS

          -  Subclinical CS

          -  Exogenous CS

          -  Previous history of major psychiatric disorder (not related to CS)

          -  Neurological disorders affecting the central nervous system

          -  High alcohol consumption (more than 14 units of alcohol per week)

          -  Active malignancy or any treatment for malignancy during the last 2 years

          -  Heart failure (NYHC II-IV)

          -  Severe respiratory insufficiency

          -  Severely impaired hepatic function (alanine transaminase and/or aspartate transaminase
             concentrations two times the upper limit of normal or above)

          -  Severely impaired renal function (serum- creatinine >150 µmol/L or glomerular
             filtration rate <45 ml/min)

          -  Pregnancy or breast feeding

          -  Any other illness that significantly affects the patients cognitive function according
             to the investigators opinion

          -  Contraindication for MRI (Presence of medical implants, metal in the body,
             claustrophobia)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Montelukast for Persistent Cough in Young People and Adults

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female, aged 16 years to 49 years inclusive.

          -  Presenting with a persistent cough of 2-8 weeks' duration without an established
             diagnosis (e.g. asthma, gastro-oesophageal reflux).

          -  Able to complete cough diary and study questionnaires.

        Exclusion Criteria:

          -  There is a contraindication to montelukast.

          -  Chronic severe disease which may cause persistent cough (eg cystic fibrosis,
             bronchiectasis, cardiac failure).

          -  Immunodeficiency/immunocompromised state.

          -  Pregnancy.

          -  Breastfeeding.

          -  Current smoker (i.e. stopped smoking less than 6 months ago).

          -  Regular medication associated with persistent cough (ACE inhibitors).

          -  The individual is in another clinical research study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: A Primary Care Behavioral Approach for Addressing Childhood Overweight

Eligibility criteria:
Inclusion criteria included that the child must be:

          1. Obese (BMI ≥ 95th percentile for age and gender) or at-risk for obesity (85th ≥ BMI >
             95th percentile for age and gender);

          2. African-American by parent report;

          3. 7-11 years of age;

          4. Without any medical or psychological condition that would make weight loss or physical
             activity dangerous, or psychological disorders that would make adoption of health
             behaviors difficult;

          5. Without any complications of obesity that indicate prompt referral to a pediatric
             obesity treatment center for more aggressive weight loss therapy;

          6. Together with the parent/caregiver indicate that they are ready to make changes in
             their eating and physical activity behaviors;

          7. Have a parent/caregiver willing to participate.

        Exclusion Criteria:

        As noted above, to participate in this study the child must not have a medical or
        psychological condition that would make weight loss or physical activity dangerous,
        psychological disorders that would make adoption of health behaviors difficult, or
        complications of obesity that necessitate prompt referral to a pediatric obesity treatment
        center for more aggressive weight loss therapy. Examples of medical or psychological
        conditions that would render the child ineligible for this study include uncontrolled or
        poorly-controlled asthma or hypertension, bulimia, mental retardation or severe learning
        disability, as well as pseudotumor cerebri, sleep apnea, obesity hypoventilation syndrome,
        and slipped capital femoral epiphysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD

Eligibility criteria:
Inclusion Criteria:

          -  Chronic kidney disease stages G3-G5 (defined according to KDIGO criteria);

          -  Anemia (defined according to KDIGO criteria) and iron deficiency defined as serum
             ferritin < 100 ng/mL and/or TSAT < 20% (KDIGO).

        Exclusion Criteria:

          -  contraindications of intravenous iron therapy: iron allergy, active infection,
             hemochromatosis, iron overload (serum ferritin > 500 ng/mL and/or transferrin
             saturation > 50%);

          -  treatment with iron and erythropoiesis-stimulating agents (at the time of recruitment
             and 6 months previously);

          -  active smoker status;

          -  antioxidant food supplements treatment in the last 3 months;

          -  clinically manifest bleeding;

          -  another cause of anemia (hemoglobinopathies, vitamin B12 and/or folic acid deficiency
             suggested by the megaloblastic peripheral blood smears's appearance, multiple myeloma
             and other paraproteinemias);

          -  severe anemia (Hb < 7 g/dl);

          -  baseline FMD < 7% (the existence of atherosclerosis which limits arterial reactivity);

          -  cancer (currently or in the past 6 months);

          -  hepatopathies (increased serum transaminases ≥ 3 x normal value) or hepatic impairment
             ≥ grade Child B;

          -  autoimmune disorders or significant inflammation (as defined by C-reactive protein > 5
             mg/L);

          -  pregnancy or lactation;

          -  participation in other clinical trials over the upast 3 months;

          -  patient unwillingness.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of Menses in Congenital Bleeding Disorders

Eligibility criteria:
Inclusion Criteria:

          1. Age between 18 and 45 years;

          2. Ascertained diagnosis of one of the following inherited bleeding disorders:

               1. Von Willebrand Disease type 1, 2, 3 severe and moderate (VWF:RCo < 30 %),as
                  diagnosed following Italian guidelines [4]

               2. Glanzmann Thromboasthenia

               3. Congenital Coagulation Factor VII, II or X deficiency

               4. A and B Haemophilia Carriers (Factor VIII and IX <25%);

          3. Bleeding Severity score > 2

          4. Signing the consent form.

        Exclusion Criteria:

        1. Under continuous anti-hemorrhagic prophylaxis 2. Affected by an active cancer or
        anti-phospholipid antibodies syndrome 3. History of liver, kidney or endocrine disorders 4.
        Submucous uterine fibroids, uterine polyps or malignancy 5. Use of oral contraceptives or
        intrauterine devices in the past three months 6. Treatment with non-steroidal
        anti-inflammatory drugs

        -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: mp3 vs Apatos in Post-extractive Sockets

Eligibility criteria:
Inclusion Criteria:

          -  18 years old or older

          -  requiring one single tooth extraction and subsequently an implant-supported
             restoration

          -  able to sign an informed consent form

        Exclusion Criteria:

          -  history of systemic diseases that would contraindicate oral surgical treatment;

          -  long-term non-steroidal anti-inflammatory drug therapy;

          -  lack of opposite occluding dentition in the area intended for extraction and
             subsequent implant placement;

          -  Oral biphosphonate therapy;

          -  absence of adjacent teeth;

          -  unwillingness to return for the follow-up examination;

          -  use of more than 10 cigarettes per day. Subjects smoking less than 10 cigarettes per
             day were requested to stop smoking before and after surgery; however, their compliance
             could not be monitored.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction