Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: The Effect of Lesion Characteristics in MRgFUS on Tremor in Essential Tremor and Parkinson's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Men and women, between 18 and 80 years.

          -  Patients who underwent the MRgFUS procedure.

          -  Patients who are able and willing to give consent and able to attend all study visits
             and Radiologic follow-up examination by MRI.

          -  A diagnosis of ET or Idiopathic PD as confirmed from clinical history and examination
             preformed by a movement disorders neurologist.

          -  ET patients: tremor severity score of greater than or equal to 2 in the treated
             hand/arm as measured by postural or action item on the Clinical Rating Scale for
             Tremor (CRST).

          -  PD patients: tremor severity score of equal or greater than 3 on either item 20 or
             item 21 of motor part in the Unified PD Rating Scale (UPDRS).

          -  Substantial disability in the performance of at least two daily activities from the
             disability subsection of the scales UPDRS for PD patients or CRST for ET patients.

          -  The patient must have a history of an unsatisfactory response to medical management.
             All patients will need to have tried and failed at least one drug. Alternatively, a
             patient may also qualify if tremor-suppressing medications are contraindicated due to
             a coexisting medical condition or drug allergy.

          -  Stable doses of all medications for 30 days prior to study entry.

        Exclusion Criteria:

          -  Patients which have not completed the MRgFUS procedure.

          -  Patients which were diagnosed during the trial with additional diagnoses that can
             affect motor function, quality of life and symptoms of tremor.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment