Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Role of Copper-Albumin Complex in Treatment of Knee Osteoarthritis in Human

Eligibility criteria:
Inclusion Criteria:

          -  Patients of both sexes and over 40 years of age diagnosed with unilateral or bilateral
             symptomatic OA of the knee who met the criteria of the American College of
             Rheumatology (ACR).

          -  Patients who were rated grade II or III on the Kellgren and Lawrence (K&L)
             radiological scale [19].

          -  Patients with symptomatic OA with a global mean pain in the knee >40 mm on a Visual
             Analogue Scale (VAS) for pain assessment.

        Exclusion Criteria:

          -  Women who were pregnant or breastfeeding

          -  Patients who were grade I or IV on K&L radiological scale.

          -  Patients who have had a prosthesis replaced in the 12 months prior to inclusion.

          -  Obesity
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome

Eligibility criteria:
Key Inclusion Criteria:

          -  Diagnosed with primary or secondary SjS according to the 2002 American European
             Consensus Group (AECG) classification

          -  Active SjS as defined by an European League Against Rheumatism (EULAR) Sjogren's
             syndrome disease activity index (ESSDAI) ≥ 5

          -  Seropositivity for antibodies to SjS-associated antigens A and/or B (anti-SSA or
             anti-SSB)

        Key Exclusion Criteria:

          -  Concurrent treatment with any biologic disease modifying antirheumatic drug (bDMARD)
             (prior bDMARD treatment allowed with appropriate washout as per study protocol)

        Note: Other protocol defined Inclusion/Exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Possible, probable (clinically or laboratory supported) or definite ALS according to
             the revised version of the El Escorial criteria (Brooks et al. 2000)

          -  Disease duration < 36 months

          -  Vital capacity of more than 50% of normal (defined as slow vital capacity, best of
             three measurements)

          -  Age ≥18 years

          -  Continuously treated with 100 mg riluzole daily for at least four weeks

          -  Capable of thoroughly understanding all information given and giving full informed
             consent according to GCP

          -  Willing to complete a diet questionnaire throughout participation in the study

        Exclusion Criteria:

          -  Simultaneous participation in another interventional clinical study

          -  Previous participation in a drug clinical trial where last intake of the trial drug
             was within the last 12 weeks

          -  Known sensitivity or intolerance to rape oil or sunflower oil, or components thereof

          -  Tracheostomy

          -  Patients with gastrostomy

          -  Pregnancy or breastfeeding

          -  Any medical condition known to have an association with motor neuron dysfunction which
             might confound or obscure the diagnosis of ALS

          -  Presence of any concomitant life-threatening disease or impairment likely to interfere
             with functional assessment.

          -  Evidence of a major psychiatric disorder or clinically evident dementia precluding
             evaluation of symptoms.

          -  Liable to be not cooperative or comply with study requirements as assessed by the
             investigator, or unable to be reached in the case of emergency.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Randomized Controlled Trial to Prevent Peritoneal Seeding in Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Histologically proven gastric adenocarcinoma: uT1,uT2, uT3, Nx, M0

          2. No prior chemotherapy

          3. Patients of full age, independent of gender ECOG ≤ 2

          4. No dissemination of the tumor confirmed by CT of the lung and the abdomen.

          5. Signed Consent form of the Patient agreeing to investigations

          6. Leucocytes > 3.000/µl

          7. Thrombocytes > 100.000/µl

          8. Creatinine ≤ 1.5mg/dl and or Clearance > 60 ml/min

          9. informed consent of the patient

         10. normal ejection-fraction of the heart

        Exclusion Criteria:

          1. Dissemination of the tumor or non-resectable primary tumor

          2. Malignant secondary disease < 5 years in the past (Exception: in-situ-carcinoma of the
             cervix and appropriately treated basal cell carcinoma of the skin)

          3. Patient not of full age

          4. Inflammatory chronic bowel disease

          5. Inclusion of the patient in a different study

          6. Pregnancy or lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: The Effects of Over-the-Counter Products on the Skin

Eligibility criteria:
Inclusion Criteria:

          -  Participants must be over the age of 18 years old with healthy skin;

          -  Participant must be willing and comply with the requirements of the protocol;

          -  Participant must have the ability to understand and communicate with the investigator;

          -  Participant must provide informed consent.

        Exclusion Criteria:

          -  Subjects who are unable to provide informed consent;

          -  Subject with significant medical history or current skin diseases that the
             investigator feels is not safe for study participation;

          -  Subjects who self-report that they are pregnant or nursing;

          -  Subjects who do not speak English or have difficulty hearing or are otherwise impaired
             for providing informed consent and communicating with the investigator;

          -  Subjects with known bleeding disorders or diathesis;

          -  Subjects with a history of keloids or excessive scarring;

          -  Subjects with known allergy to lidocaine, epinephrine, or any of the tested products;

          -  Subjects who foresee intensive UV exposure during the study (e.g. sunbathing, tanning
             beds).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Postural Sway at Menstrual Cyclus

Eligibility criteria:
Inclusion Criteria:

          -  Have dysmenorrheal syndrome

          -  Have menstrual cycle without pain

        Exclusion Criteria:

          -  Have another health problem (systemic, neurologic, orthopedic or psychiatric)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Neuraxial Pethidine After Lumbar Surgery Trial

Eligibility criteria:
Inclusion Criteria:

          -  Adults undergoing lumbar spinal surgery

        Exclusion Criteria:

          -  Lack of informed patient consent

          -  Acute or chronic renal failure

          -  Known allergy or intolerance to pethidine or tramadol

          -  Chronic respiratory insufficiency

          -  Epidural contraindicated (coagulopathy, systemic infection)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Prevention of Cystitis.

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
             inclusion criteria may choose to answer the questionnaire in the waiting room of
             general practitioners selected by lot.)

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Osteoporosis Associated Vertebral Fractures - Medical and Socio-economic Aspects in Austria

Eligibility criteria:
Inclusion Criteria:

        -patients older than 50 years of age with vertebral fractures at the thoracic or lumbar
        spine caused by a low-energy trauma or without any trauma, or with vertebral fractures at
        the thoracic or lumbar spine with typical osteoporotic deformity of the vertebrae (wedge,
        fish, or flat)

        Exclusion Criteria:

          -  patients younger than 50 years of age

          -  vertebral fractures at the cervical spine

          -  vertebral fractures at the thoracic or lumbar spine caused by a high-energy trauma
             (motor-vehicle accident, sports-related accident, fall from a considerable height)

          -  patients suffering from a malignancy, making a pathological fracture presumably,
             patients with vertebral fractures, whose dataset of follow-up monitoring was lacking,
             to make an evaluation of osteoporotic involvement impossible
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Semen Analysis and Insight Into Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  infertile males

        Exclusion Criteria:

          -  suergery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment