Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Hormonal Effects on the Uterus and Endometrium

Eligibility criteria:
-  INCLUSION CRITERIA:

        Healthy volunteers will be in excellent health.

        Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms,
        diaphragm) or sterilization methods of contraception will be included.

        Only women with a negative pregnancy test, normal physical examination and laboratory
        results, and a luteal phase progesterone value of greater than 4 ng/mL will be entered into
        this study.

        Women with endometriosis will be recruited from those with histologically-proven
        endometriosis. Except for this diagnosis they will meet criteria for healthy volunteers as
        stated above.

        Women may participate in the study on more than one occasion, but biopsies may not be
        performed in a "baseline" cycle.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Clinical Intramuscular Gene Transfer Trial of rAAVrh74.MCK.Micro-Dystrophin to Patients With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Age 7 or older; must be wheelchair-dependent

          -  Confirmed Dystrophin mutations based on mutation compatibility with micro-dys cDNA
             based on previously published methods.

          -  Males of any ethnic group will be eligible.

          -  Ability to cooperate with muscle testing.

          -  Willingness of sexually active subjects with reproductive capacity to practice
             reliable method of contraception (If appropriate).

        Exclusion Criteria:

          -  Active viral infection based on clinical observations.

          -  Symptoms or signs of cardiomyopathy, including:

               -  Dyspnea on exertion, pedal edema, shortness of breath upon lying flat, or rales
                  at the base of the lungs

               -  Echocardiogram with ejection fraction below 40%

          -  Serological evidence of HIV infection, or Hepatitis A, B or C infection

          -  Diagnosis of (or ongoing treatment for) an autoimmune disease

          -  Concomitant illness or requirement for chronic drug treatment that in the opinion of
             the PI creates unnecessary risks for gene transfer.

          -  Subjects with AAVrh74 binding antibody titers ≥ 1:50 as determined by ELISA
             immunoassay.

          -  Abnormal laboratory values in the clinically significant range as defined in protocol
             or based upon normal values in the Nationwide Children's Hospital Laboratory.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effectiveness of Nanoone Woman Underwear Using in the Management of Dysmenorrhea

Eligibility criteria:
Inclusion Criteria:

          1. Females aged below 40 years old.

          2. Screened by inquiry and diagnosed as primary dysmenorrhea by gynaecologist with pelvic
             ultrasonography.

          3. Female subject who is:

               -  using adequate contraception since last menstruation and no plan for conception
                  during the study.

               -  non-lactating.

               -  has negative pregnancy test (urine) within 14 days prior to the study.

          4. Informed consent form signed.

        Exclusion Criteria:

          1. Sensitivity to study product.

          2. Patient has been diagnosed with secondary dysmenorrhea (defined as identifiable pelvic
             pathology).

          3. Patient has clinically significant physical disability or abnormal findings on
             physical examination or laboratory testing judged by the investigator or
             co-investigator.

          4. Participation of any clinical investigation during the last 30 days.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Measurement of Gait Spatio-Temporal Characteristics in Knee Osteoarthritis Patients

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee OA for at least 6 months

          -  Fulfilled American College of Rheumatology clinical criteria for OA of the knee

          -  Radiographically assessed OA of the knee graded 1-4 according to the Kellgren &
             Lawrence scale

        Exclusion Criteria:

          -  Acute septic arthritis

          -  Patients with an increased tendency to fall

          -  Lack of physical or mental ability to perform or comply with the treatment procedure

          -  Diabetes mellitus

          -  History of pathological osteoporotic fracture
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: The Influence of Lidocaine Volume on Discomfort During Administration of Local Anesthetic

Eligibility criteria:
Inclusion Criteria:

          -  age 18 - 65

        Exclusion Criteria:

          -  regular use of analgesics

          -  known hypersensitivity of local anaesthetic

          -  renal-, heart- or liver disease

          -  known peripheral neuropathy or diabetes mellitus

          -  local infection on injection site

          -  circulation disorders in upper extremities (e.g. Raynaud´s phenomenon)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of idiopathic hypogonadotropic hypogonadism (IHH) or Kallmann syndrome
             (KS)Adult male 18-65 years of age

          -  Serum testosterone <100 ng/dL

        Exclusion Criteria:

          -  No specific exclusion criteria
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  Male, ages 18-68

          -  Serum total testosterone less than or equal to 275 ng/dL

        Exclusion Criteria:

          -  Significant intercurrent disease of any type, in particular, liver, kidney or heart
             disease, uncontrolled diabetes mellitus or psychiatric illness.

          -  Abnormal prostate digital rectal examination, elevated PSA, AUA symptom score of >15,
             and/or history of prostate cancer.

          -  Hematocrit of <35 or >50%

          -  BMI >36

          -  Serum transaminases > 2 times upper limit of normal or serum bilirubin > 2.0 mg/dL
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 68 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Assisted Hatching in Frozen Blastocysts

Eligibility criteria:
Inclusion Criteria:

          -  In-vitro fertilization patients at the investigators' institution, intended to undergo
             a transfer of a frozen five-day embryo (blastocyte)

          -  18 to 39 years old

          -  First to third treatment cycle

          -  Patient has previously had a maximum of four embryos transferred.

        Exclusion Criteria:

          -  Over 40 years old

          -  Congenital or acquired uterine malformations

          -  Hydrosalpinx

          -  Chronic autoimmune diseases

          -  Embryo intended to be undergo preimplantation genetic diagnosis
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Promoting Overweight Adolescents Physical Activity

Eligibility criteria:
Inclusion Criteria:

          -  13-16 years old,

          -  overweight or obese (weight for height >20% over normality)

        Exclusion Criteria:

          -  mental health problems, long term illnesses.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Research Platform to Screen Healthcare Workers

Eligibility criteria:
Inclusion Criteria:

          -  Individuals who work within a food production, healthcare, research or clinical
             organization.

          -  Asymptomatic as per daily screening.

          -  No contraindication to performing a NP swab.

        Exclusion Criteria:

          -  Any individual with fever, respiratory or flu-like symptoms will not be eligible.
             Symptom positive individuals who were not picked up at entry screening will be
             referred to their Occupational Health. Specific symptoms include:

               -  Fever, chills or headache

               -  New or worsening cough

               -  Shortness of breath, difficulty breathing, sore throat or difficulty swallowing

               -  Runny nose or stuffy nose without another cause (e.g. allergies)

               -  Nausea/vomiting, diarrhea, stomach pain

               -  Decrease/loss of taste or smell

               -  Unexplained fatigue, malaise, muscle aches

               -  Eye pain or pink eye In addition to those symptoms listed above, individuals
                  should also be screened for symptoms as per their institutional requirements.

          -  Enrolled in a COVID-related interventional study (eg. Behavioural or drug study).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction