Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Study of Heritable Connective Tissue Disorders

Eligibility criteria:
INCLUSION CRITERIA:

        Individuals and their family members will be offered enrollment if they have a suspected or
        established diagnosis of Marfan, Stickler, Ehlers-Danlos, or a closely related syndrome.

        Personal or family history of one or more of the following features in a pattern suggestive
        of a heritable connective tissue disorder:

        Marfanoid body habitus;

        Aortic dilatation and/or dissection;

        Ectopia lentis, detached retina, vitreous degeneration and/or early onset high myopia;

        Posterior cleft palate; joint laxity and/or dislocation;

        Premature osteoarthritis;

        Skin fragility, striae, easy bruisability and/or hyperextensibility;

        Pectus excavatum or carinatum;

        Scoliosis, spondylolisthesis, and/or dural ectasia;

        High frequency sensorineural hearing loss.

        EXCLUSION CRITERIA:

        Inability to provide informed consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: On-line Neuromuscular Exercise and Education for Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee OA symptoms resulting in contact with the health care system

        Exclusion criteria (both study groups):

          -  Another reason than OA for the problems; includes tumour or inflammatory joint disease

          -  Other symptoms that are more pronounced than the OA symptoms; i.e. chronic,
             generalised pain or fibromyalgia.

        In addition, for the on-line study group:

          -  Previous participation in similar exercise and education programs (i.e. the on-site
             version)

          -  Lack of necessary equipment or skills to administer on-line participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Investigation of Acute Effect of ESWT and ESWT+KT on Pain and Grip Strength

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Lateral Epicondylitis Disease

          -  has been doing professional sports for at least three years

        Exclusion Criteria:

          -  Having systemic problems,

          -  Having health problems,

          -  Has undergone any surgical operation in the upper extremity

          -  Has suffered upper extremity injury in the last three months

          -  Lack of inclusion criteria

          -  Neurological and orthopedic problems of the upper extremity.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Early Diagnosis of Pulmonary Fibrosis - Diagnostic Delay

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of IPF according to international guidelines

        Exclusion Criteria:

          -  Unable to provide written informed consent

          -  Radiologic, histologic, or clinical findings inconsistent with a diagnosis of IPF
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: The Added Value of CT Scanning in Patients With an Unilateral Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Thoracocentesis

          -  Chest X-ray and

          -  CT-scanning are performed

        Exclusion Criteria:

          -  Lung cancer

          -  Other thoracic malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women

Eligibility criteria:
Inclusion Criteria:

          -  Infertility

          -  The length of menstrual cycle longer than 35 days or shorter than/amenorrhea

          -  Serum FSH levels ≥10mIU/ml/ serum AMH levels ≤1.0pg/ml/ AFC ≤7, on at least two
             occasion >4 weeks apart

        Exclusion Criteria:

          -  Polycystic Ovarian Syndrome

          -  other causes of amenorrhea
Female
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Clinical Study to Assess the Natural History of COVID-19 and Effects of KB109 and Supportive Self-care in Outpatients With Mild-to-moderate COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Be male or female, ≥18 years of age

          -  Be willing and able to give informed consent

          -  Screening/Randomization telemedicine visit within 2 days of testing positive test for
             COVID-19

          -  Having self-reported fever or cough for not more than 72 hours prior to COVID-19
             testing

          -  Mild to moderate COVID-19

          -  Able to adhere to the study visit schedule and other protocol requirements.

        Exclusion Criteria:

          -  Patients who are hospitalized for in-patient treatment or currently being evaluated
             for potential hospitalization at the time of informed consent for conditions other
             than COVID- 19

          -  History of chronic lung disease

          -  Ongoing requirement for oxygen therapy

          -  Shortness of breath in resting position

          -  Diagnosis of sleep apnea requiring Bilevel Positive Airway Pressure (BIPAP) /
             Continuous Positive Airway Pressure (CPAP)

          -  Female patients who are pregnant, trying to become pregnant or lactating

          -  Is considered, in the opinion of the PI, to be unlikely for any reason to be able to
             comply with study procedures
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: A Study to Determine the Location of the Blind Spot and the Macula-disc Centre Distance on a Fundus Photograph

Eligibility criteria:
Inclusion Criteria:

          -  No disease that effect the fundus photograph or visual field

        Exclusion Criteria:

          -  any disease that effects the fundus photograph or visual field
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Rate of Complete Symptom Relief, Prevention of Symptom Relapse: Grades A and B Esophagitis of Esomeprazole Therapy

Eligibility criteria:
Inclusion Criteria:

          -  patients between the ages of 15 and 80 years

          -  with clinical symptoms of acid regurgitation, heart burn, or feeling of acidity in the
             stomach,

          -  who have Los Angeles Grade A and B erosive esophagitis proven by endoscopy are
             recruited.

        Exclusion Criteria:

          1. coexistence of peptic ulcer or gastrointestinal malignancies,

          2. pregnancy,

          3. coexistence of serious concomitant illness (for example, decompensated liver cirrhosis
             and uremia),

          4. previous gastric surgery,

          5. allergy to esomeprazole,

          6. symptom score of a validated questionnaire (Chinese GERDQ) less than 12, and

          7. equivocal endoscopic diagnosis of Los Angeles Grade A and B erosive esophagitis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia A Patients.

Eligibility criteria:
Inclusion Criteria:

          -  Male patients who are diagnosed with severe (laboratory tested FVIII:C <2%) hemophilia
             A;

          -  Patients Who Completed trial of SCT800-A302 or SCT800-A 303 and New PTP(previously
             treated patients)(Previously received FVIII prophylactic or bleeding treatment, have
             the relevant records and are verified to have accumulated exposures days( EDs) ≥150
             days;

          -  Negative FVIII inhibitor assay results (laboratory tested Nijmegen-Bethesda assay
             result <0.6 BU(Bethesda unit)/mL);

          -  The treatment records of at least 50EDs before screening can be obtained;

          -  HIV negative; if HIV positive, the viral load <200 particles/uL or <400,000 copies/mL,
             and HIV patients must satisfy CD4+ count >200/μL;

          -  The patient or his guardian voluntarily signed the Informed Consent Form.

        Exclusion Criteria:

          -  Known allergy to any coagulation factor VIII or any excipient; known allergy to
             bovine, rodent or hamster bovine;

          -  Has a history or family history of blood coagulation factor VIII inhibitor;

          -  Patients with other coagulation dysfunction diseases in addition to hemophilia A;

          -  Patients with other clinically significant diseases, alcoholism, drug abuse, mental
             disorders or intellectual disabilities;

          -  Patients with other severe or clinical significant diseases verified by the
             investigator to be unable to benefit from the clinical study;

          -  Patients who participated in other clinical studies within one month before the first
             drug administration (except FVIII trials) and patients who participated in other FVIII
             clinical trials after signing the Informed Consent Form;
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction