Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Mulligan Manual Therapy and Trunk Stabilization Exercises Versus Isometric Knee Strengthening on Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  - Both gender (female and male) patients

          -  Age between 40 - 60

          -  Knee osteoarthritis Grade I & II on Kellgren and Lawrence (K/L) criteria

          -  Prediagnosed case of knee OA as per the American College of Rheumatology (ACR).

        Exclusion Criteria:

          -  Known skin allergies

          -  Sensory-motor dysfunction of lower extremity

          -  Severe joint deformity of lower extremity

          -  Post Traumatic Arthritis

          -  Constitutional Symptoms (Fever, Malaise, Weight Loss and high blood pressure)

          -  Knee Intraarticular injection in past 3 months

          -  Acute low back pain

          -  History of spinal surgery

          -  Subject using assistive devices for ambulation i.e. cane, walkers, sticks

          -  Refused to give consent

          -  Body Mass Index > 30 kg/m2

          -  Received physiotherapy treatment in the past 3 months

          -  Visual Analogue Scale <4

          -  Patellofemoral joint arthritis will be excluded
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluation of Static Postural Balance in Children With Hemophilia and Its Relationship With Joint Health

Eligibility criteria:
Inclusion Criteria:

          -  Aged 6 to 18 years

          -  Participants do not perform regular physical activity and sports.

          -  For hemophilia group who developed hemophilic arthropathy in at least one of the lower
             limb joints due to severe hemophilia (total lower limb hemophilia joint health score
             ≥3).

          -  For hemophilia group patients to be receiving prophylaxis but have no major bleeding
             that could affect the musculoskeletal system in the past two weeks

        Exclusion Criteria:

          -  Have any auditory and visual impairment

          -  Undergo any orthopedic injuries including lower limb

          -  Have any neurological or cognitive disorders
Male
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Micromechanical Modeling Using Low Magnitude Mechanical Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  Females, ages 45-65 years and post menopausal, as defined by a history of amenorrhea
             for a minimum of 24 months and a serum FSH (follicle-stimulating hormone)
             concentration of 25 mIU/mL (milli-International unit per milliliter) and negative
             pregnancy test.

        Exclusion Criteria:

          -  Current or prior use of medications known to affect bone (e.g. bisphosphonates,
             calcitonin, selective estrogen receptor modulators, denosumab, diphenylhydantoin,
             recent systemic glucocorticoid use), bone mineral density T score of less than -2.5
             and greater than +2, Vitamin D level less then 12 ng/ml, BMI (body mass index) of
             greater than 32, current alcohol or drug abuse: more than 3 alcoholic beverages per
             day or current abuse of illicit drugs or prescription medication, uncontrolled or
             untreated cardiac or pulmonary disease liver disease: history of hepatitis or ALT
             (alanine aminotransferase) or AST (aspartate aminotransferase) greater than 2x ULN
             (upper limit of normal), renal disease: history of renal disease or serum creatinine
             greater than 2x ULN diabetes, pacemaker or metallic implants considered a
             contraindication to MR scanning.
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Stress Management Therapy for Meniere's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed as Meniere's patients according to the 1995 AAO-HNS criteria are
             included into this study.

        Exclusion Criteria:

          -  Patients refused our prepared four kinds of treatments are excluded from this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Assess the Ability of MetroGel 1% to Deliver Moisture to Facial Skin After a Single Application

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of moderate to severe rosacea, defined as the presence of at least
             moderate erythema with telangiectasia and a minimum of two inflammatory lesions

        Exclusion Criteria:

          -  Individuals with active symptoms of allergy (mild active seasonal allergies are
             acceptable) or atopic dermatitis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Vaginal Prednisone Administration for Prevention of Adrenal Crisis

Eligibility criteria:
Inclusion Criteria:

          -  Female patients with chronic primary adrenal insufficiency due to autoimmune
             adrenalitis or bilateral adrenalectomy (disease duration at least 6 months)

          -  Age ≥ 18 years

          -  Patient´s written informed consent

          -  Ability to comply with the protocol procedures

          -  Established stable replacement therapy, no anticipated change in medication

          -  Negative pregnancy test and contraception (besides oral contraceptive pill) in
             pre-menopausal females

        Exclusion Criteria:

          -  Diabetes mellitus

          -  Infectious disease with fever at time of investigation

          -  Known intolerance to the study drug or constituents

          -  Oral contraception

          -  Pregnancy or breast feeding

          -  Renal failure (creatinine >2.5 ULN)

          -  Disposition to vaginal mycosis (requiring treatment in the last 6 months or of
             necessity >2 antimycotic therapies/year)

          -  Recurrent urinary tract infections (of necessity >2 antibiosis therapies/year)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Efficacy and Safety of Diclofenac Sodium Gel in Hand Osteoarthritis

Eligibility criteria:
Key Inclusion criteria:

        • Osteoarthritis of the hand

        Key Exclusion Criteria:

          -  Other rheumatic disease, such as rheumatoid arthritis

          -  Active gastrointestinal ulcer during the last year

          -  Known allergy to analgesic drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Multicentric Registry of Patients With Acute Leukemia Infected by COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of acute leukemia according to WHO criteria 2016 ≤ 5 years

          -  Diagnosis of a proven or probable SARS-CoV-2 infection according to the following
             criteria:

               1. Proven infection: positive Polymerase Chain Reaction (PCR) regardless of the
                  radio-clinical picture (other tests made available later and having good
                  diagnostic performance will be accepted)

               2. Probable infection: negative PCR but association of

                    1. Evocative clinical signs, of recent installation: fever, respiratory signs
                       (cough, dyspnea, chest pain), body aches, sore throat, rhinorrhea, headache,
                       diarrhea / abdominal pain, frank asthenia, loss of taste / smell,
                       conjunctivitis, type of frostbite AND

                    2. evocative radiological signs, on CT: diffuse or diffuse aspect of frosted
                       glass, condensations including pseudo-nodular condensations, association of
                       frosted glass and condensation within the same lesion, nodules and
                       micronodules, thickening of the interlobular septa) or on chest radiography:
                       interstitial, alveolo-interstitial or alveolar syndrome, single or bilateral
                       AND

                    3. absence of differential diagnosis

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: PET MRI for Evaluation of Knee Osteoarthritis in Patients With Bilateral Knee OA

Eligibility criteria:
Inclusion Criteria:

          -  All patients that are sent for knee MRI

          -  Patients over the age of 50 years old

          -  All patients will sign an informed consent for the study prior to the PET MRI

          -  Unilateral or Bilateral knee pain

          -  All patients were ambulatory pre-operatively, using no more then a single cane

          -  All patients had prior Weight Bearing AP x-rays and Lateral Radiogrphs

        Exclusion Criteria:

          1. Non ambulatory patients

          2. History of knee arthroscopy or other surgery 1 year before the MRI

          3. Bone scan performed in the past 3 months prior to the PET MRI

          4. Clastrophobia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)

Eligibility criteria:
Inclusion Criteria:

          1. All recruited patients should be diagnosed with Sjogren's syndrome alone or in
             association with other autoimmune conditions (rheumatic or not) based on their
             rheumatologist opinion or have clinical and serological/imaging features which in the
             opinion of their clinician raise the suspicion of Sjogren's syndrome.

          2. Patients with symptoms onset /imaging, serological and glandular biopsy abnormalities
             suggestive of SS (suspected SS) or SS diagnosis made by expert clinicians prior to age
             18

          3. Patients/ Carers who can provide informed consent and agree to provide access to the
             results of their routine care investigations for research purposes irrespective of
             being able provide blood or saliva samples.

          4. Patients of 6 years or age or above

        Exclusion Criteria:

        1. Inability to provide informed consent or have informed consent provided on their behalf.
No condition on gender to be admitted to the trial.

Subject must be at least 6 Years old.


Eligibility (NLI label): Contradiction