Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops

Eligibility criteria:
Inclusion Criteria:

          -  18-80 years of age, diagnosed with glaucoma, including primary open-angle glaucoma or
             primary angle closure glaucoma, require treatment with anti-glaucoma eye drops.

          -  A group: Patients using glaucoma eye drops longer than 6 months, and in accordance
             with the diagnostic criteria of dry eye:

               1. Subjective symptoms (required): dryness, foreign body sensation, fatigue and
                  discomfort;

               2. The instability of tear film (required): tear break up time (TBUT);

               3. Lacrimal secretion: Schirmer I test;

               4. The ocular surface damage (strengthen diagnosis): fluorescein staining (FL); in
                  the mentioned in ①+②（TBUT≤5s) or ①+②（TBUT≤10s)+③（<10mm）/④（FL+）。

          -  The choice of study eyes: Choose the eye of the patient with low basical intraocular
             pressure, and if the basal intraocular pressure is the same, choose the right eye for
             the study.

          -  Voluntary participation in this clinical study, and signed informed consent.

        Exclusion Criteria:

          -  With metabolic diseases, autoimmune diseases, connective tissue diseases, such as
             diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus,
             Sjogren's syndrome eat;

          -  Combined with cerebrovascular, liver, kidney, hematopoietic serious system desease,
             atumor diseases and psychosis.

          -  Using any artificial tears and except any clinical trials of dry eyes within two
             weeks.

          -  With drug therapy, embolization and surgical treatment of dry eyes.

          -  With other eye diseases, such as eyelid defects, hypophasis, pterygium, chronic
             dacryocystitis, trichiasis, corneal lesions.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction