Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: A Study to Assess the Effect of ASP1585 on Pharmacokinetics of Atorvastatin in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Body weight: =<50.0kg, <80.0kg

          -  Body mass index: =<17.6, <26.4

          -  Healthy as judged by investigator or caregiver from subjective and objective symptoms
             and physical examination data

        Exclusion Criteria:

          -  Attending another clinical trial within 120 days before the study

          -  Blood donation within 90 days (400ml) or 30 days (200ml) before the study

          -  Receiving any drugs within 7 days before the study

          -  History of allergy to drugs

          -  Having GI disorders

          -  History or complication of liver diseases

          -  History or complication of heart disease

          -  History or complication of respiratory diseases

          -  History or complication of renal diseases

          -  History or complication of cerebrovascular diseases
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 44 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: TEM-PCR™ Prospective Clinical Utility Study

Eligibility criteria:
Inclusion Criteria:

          1. Provide written informed consent for the trial;

          2. Age 65 years or older;

          3. In the opinion of the investigator, subject has the cognitive ability to provide
             accurate information to study site personnel and to follow instructions, or subject
             has a caregiver who can provide accurate information and ensure subject's compliance
             with instructions;

          4. Presentation with at least two of the following symptoms of acute respiratory illness:

               1. nasal congestion

               2. chest congestion

               3. shortness of breath

               4. cough

               5. body ache

               6. fever (≥100.4 ºF)

        Exclusion Criteria:

          1. Subject is currently taking antibiotics or has taken antibiotics within the previous
             30 days.

          2. Subject is currently taking antivirals or has taken antivirals within the previous 30
             days.

          3. Subject has been hospitalized within the previous 30 days.

          4. Severity of illness (according to the Investigator) requires immediate hospitalization
             or referral to specialty care.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Pain Related Sexual Dysfunction After Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Male patients

          -  >18 yrs

        Exclusion Criteria:

          -  Research protection
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Parents or legally authorized representatives must give signed informed consent before
             any trial-related activities

          -  IGF-1 SDS of ≤ -1 for age and gender

          -  Short stature, as defined by a height SDS of ≤ -2 for age and gender

          -  Chronological age ≥ 5 years

          -  Bone age ≤ 11 years in boys and ≤ 9 years in girls

          -  GH sufficiency, defined as a maximal stimulated GH response of greater than or equal
             to 10 ng/mL at Visit 2 (note: upon approval of the Medical Monitor, the result of a
             prior GH stimulation test may satisfy this requirement).

          -  Prepubertal status

          -  Adequate nutrition as evidenced by a body mass index (BMI) greater than or equal to
             the 5th percentile for age and gender

        Exclusion Criteria:

          -  Severe Primary IGFD (defined as height and IGF-1 SDS ≤ 3, and stimulated GH response
             greater than or equal to 10 ng/mL)

          -  Prior or current use of medications with the potential to alter growth patterns
             including GH, IGF-1, IGFBP-3, gonadotrophin agonists (e.g., Lupron), aromatase
             inhibitors, androgens and estrogens

          -  Known or suspected allergy to rhGH, rhIGF-1 or a constituent of their formulations

          -  Current use of medications for attention deficit disorder

          -  A chronic health condition that requires anti-inflammatory steroids or daily
             medication unless approved by the Medical Monitor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study

Eligibility criteria:
Inclusion Criteria:

          1. Able to read, comprehend, and complete the consent form

          2. Aged ≥18

          3. Clinically fit for endoscopy

          4. Referred for endoscopy via any clinical pathway

        Exclusion Criteria:

          1. Known upper GI conditions with or without ongoing endoscopic monitoring including
             Barrett's oesophagus, oesophageal dysplasia, gastric ulcers, duodenal polyps or any
             established upper GI malignancy

          2. Previous oesophagectomy, gastrectomy for malignant disease

          3. OGD performed within last 3 years of study initiation

          4. Oesophageal stricture precluding completion of diagnostic endoscopic examination

          5. Coagulopathy or anticoagulant/antiplatelet therapy for high risk conditions making non
             possible to discontinue the medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: FORCE (Falls, Fracture, and Osteoporosis Risk Control Evaluation) Study

Eligibility criteria:
Inclusion Criteria:

          -  55 years of age or older

          -  independent living within the city of Sault Ste. Marie, Ontario, Canada

          -  capable of providing informed consent

        Exclusion Criteria:

          -  not at risk for falls

          -  unable to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?

Eligibility criteria:
Inclusion Criteria:

          -  Natural cycles, in which a frozen-thawed day 3 embryo is replaced.

          -  Signed informed consent.

          -  Regular cycle (i.e. between 26 and 35 days)

          -  Normal transvaginal ultrasound at screening, without evidence of clinically
             significant abnormality consistent with finding adequate for ART with respect to
             uterus and adnexa.

          -  Embryos frozen by vitrification.

          -  Single or dual embryo transfer.

        Exclusion Criteria:

          -  Known allergic reactions to progesterone products.

          -  Intake of experimental drug within 30 days prior to study start.

          -  Contraindication for pregnancy.

          -  Embryos of women above 39 years of age at the time of embryo freezing.

          -  Recipients of oocyte donation cycles
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Observational Patient Diary Study of Treatment Doses for Patients With Haemophilia With Inhibitors to Factors VIII and IX

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects with congenital haemophilia A or B and inhibitors with spontaneous
             bleeds which require on-demand treatment

          -  Subjects prescribed NovoSeven® as the first line or recommended bypass agent

          -  History of on average at least 4 bleeds of any type over a 3 month period

          -  Subject or caregiver able and willing to complete daily journal for 3 months

          -  Informed consent obtained from all subjects or legal representative
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Sleep Position May Reduce Acid Reflux Symptoms at Night

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients between the ages of 18 and 65;

          -  Between 5'4" and 6'2"

          -  Body Mass Index<32

          -  Willing and able to provide written informed consent;

          -  Understands the clinical study requirements and is able to comply with the follow-up
             schedule set forth in the protocol;

          -  Clinically diagnosed with gastroesophageal reflux disease with extra-esophageal
             symptoms (i.e. chronic cough, choking, aspiration, chronic post nasal drip, globus,
             sore throat, throat clearing);

          -  Presents with Reflux Symptom Index (RSI) > 13;

          -  Undergoing Esophagogastroduodenoscopy (EGD) as part of routine care;

          -  Undergoing 96-hour pH monitoring via BRAVO capsule as part of routine care.

        Exclusion Criteria:

          -  Currently being treated with another investigational medical device and/or drug;

          -  Currently receiving treatment for sleep apnea with continuous positive airway pressure
             (CPAP);

          -  Female patients who are of child-bearing potential and not using an acceptable method
             of birth control, or is pregnant or breast-feeding;

          -  Suspected esophageal cancer;

          -  Confirmed nasopharyngeal cancer;

          -  Previously undergone Nissen Fundoplication;

          -  Hiatal hernia > 4 cm
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: A Trial of Magnesium Dependent Tinnitus

Eligibility criteria:
Inclusion criteria:

          -  Normal Kidney function (last checked within 6 months). Serum creatinine levels 1.5
             mg/dL or below for females, 2.0 mg/dL for males.

          -  An audiogram within the past 6 months

          -  Mayo Clinic patients who live in Phoenix area

        Exclusion criteria:

          -  Any participant with decreased kidney function within past 6 months, over 1.5 mg/dL
             for females and over 2.0 mg/dL for males.

          -  Current treatment with Lithium

          -  Tinnitus rating with 0, 1, or 2 on the 0-10 Tinnitus scale
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment