Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Impact of Folates in the Care of the Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Couple whose man is from 18 to 60 years old

          -  Couple whose man presents an infertility indicating a care in VITRO fertilization with
             or without intracytoplasmic sperm injection (IVF +/- ICSI)

          -  Couple whose spouse is from 18 to 38 years old

          -  Couple whose spouse do not present particular factors of infertility

          -  Couple Taken care in IVF +/- ICSI

          -  Couple with social insurance

          -  2 members of the couple having signed the consent

        Exclusion Criteria:

          -  Etiology of not genetic known male infertility : infertility of neoplastic origine,
             infertility of definitive obstructive origin

          -  Presence of a factor of feminine infertility : A definitive infertility tubal, Turned
             out ovarian incapacity (FSH > 9 and/or CFA <= 8)

          -  Male infertility requiring the appeal to some sperm testicular or in some frozen
             sperm- Men or women attend of HIV or hepatitis B or C

          -  Epileptic men

          -  Men under anti-folic treatment

          -  Men presenting a big sensibility to the folic acid or to one of the constituents of
             the drug

          -  Couple of which one of the partners refuses to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Somatropin + Leuprorelin vs Somatropin Alone in Pubertal Children With Idiopathic Short Stature

Eligibility criteria:
Inclusion Criteria:

          -  male or female children with ISS

          -  age greater than or equal to 8 years and less than or equal to 12 years and 3 months
             for girls and greater than or equal to 9 years and less than or equal to 14 years and
             3 months for boys

          -  bone age less than or equal to 12.0 years for girls and less than or equal to 14.0
             years for boys based on a central reading of an X-ray of the left hand and wrist

          -  Pubertal stage B2 and B3 for girls based on the Tanner method

          -  Pubertal stage G2 and G3 for boys based on the Tanner method

        Exclusion Criteria:

          -  Growth hormone deficiency (GHD)

          -  Insulin-like growth factor-I levels greater than 3 SDS

          -  Chromosomal abnormality diagnosed locally on a karyotype. For girls, the karyotype to
             eliminate a Turner syndrome, is mandatory

          -  Small for gestational age (SGA)

          -  Has reached menarche (had her first menstrual period)

          -  Have any significant concomitant disease that is likely to interfere with growth or
             with the study, or is a known contraindication to Growth Hormone treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 171 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls

Eligibility criteria:
Inclusion Criteria:

          -  Adolescent girls 13-21 years old with bone age ≥ 14 years

          -  Overweight girls: Body Mass Index (BMI) greater than the 95th percentile for age

          -  Waist/Hip ratio ≥ 0.85

          -  Insulin Like Growth Factor -1 (IGF-1) below -0.5 standard deviations (SD) for pubertal
             stage or age

        Exclusion Criteria:

          -  Pregnancy (positive pregnancy test) prior to enrollment in the study

          -  Significant weight gain or loss within 3 months of study (more than 5 kg)

          -  Use of medications that affect GH or cortisol levels (such as estrogen including oral
             contraceptive pills, oral glucocorticoids)

          -  Use of medications such as Meridian and Orlistat

          -  Presence of diabetes mellitus

          -  Uncontrolled Thyroid disorders

          -  Chronic renal insufficiency

          -  Participation in another simultaneous medical investigation or trial

          -  Active neoplasm or history of cancer

          -  Prader-Willi syndrome

          -  History of scoliosis if bone age is <15 years

          -  Hypersensitivity to rhGH or constituents of the injections
Female
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema Associated With Rosacea

Eligibility criteria:
Key Inclusion Criteria:

          1. Male or female who is at least 18 years of age or older.

          2. A clinical diagnosis of facial rosacea.

          3. A Clinician Erythema Assessment (CEA) score of greater than or equal to 3 at Screening
             and at Baseline/Day 1 (prior to the study drug application).

          4. A Patient Self Assessment (PSA) score of greater than or equal to 3 at Screening and
             at Baseline/Day 1 (prior to the study drug application).

        Key Exclusion Criteria:

          1. Particular forms of rosacea (rosacea conglobata, rosacea fulminans, isolated
             rhinophyma, isolated pustulosis of the chin) or other concomitant facial dermatoses
             that are similar to rosacea such as peri-oral dermatitis, demodicidosis, facial
             keratosis pilaris, seborrheic dermatitis, acute lupus erythematosus, or actinic
             telangiectasia.

          2. Presence of three (3) or more facial inflammatory lesions of rosacea.

          3. Current treatment with monoamine oxidase (MAO) inhibitors, barbiturates, opiates,
             sedatives, systemic anesthetics, or alpha agonists.

          4. Less than 3 months stable dose treatment with tricyclic antidepressants, cardiac
             glycosides, beta blockers or other antihypertensive agents.

          5. Current diagnosis of Raynaud's syndrome, thromboangiitis obliterans, orthostatic
             hypotension, severe cardiovascular disease, cerebral or coronary insufficiency, renal
             or hepatic impairment, scleroderma, Sjögren's syndrome, or depression.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: PRF in Management of Chronic Multiple Oral Ulcers

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Oral ulcers due to Benin mucous membrane pemphioid, Pemphius vulgaris
             and Steven Johnson's Syndrome with mucositis score 4 and pain score 10

        Exclusion Criteria:

          -  patients with any systemic other systemic condition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of asbestosis

        Exclusion Criteria:

          -  other diseases
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Routine Screening for Eosinophilic Esophagitis in Patients Presenting With Dysphagia

Eligibility criteria:
Inclusion Criteria:

          -  age > 18

          -  complaint of dysphagia

        Exclusion Criteria:

          -  pregnancy

          -  age <18

          -  on inhaled steroids within the last 30 days

          -  on systemic steroids in the last 30 days

          -  known diagnosis of Eosinophilic Esophagitis

          -  obvious obstructive etiology found at endoscopy

          -  increased risk of bleeding (on blood thinners or anti-platelet agents other than
             aspirin)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Circulating Non-coding RNAs and Cardiovascular Outcomes in Patients With Dyslipidemia and Atherosclerosis

Eligibility criteria:
Inclusion Criteria:

          1. Dyslipidemia: Total cholesterol (TC) >200 mg/dL; LDL-C > 130 mg/dL ; TG > 200 mg/dL;
             male HDL-C < 40 mg/dL, female HDL-C < 50 mg/dL, or under lipid lowering therapy

          2. Atherosclerotic vascular disease:

               1. Coronary atherosclerosis as evidenced by cardiac catheterization examination,
                  having history of myocardial infarction as evidenced by ECG or hospitalization,
                  angina patient showing ischemic ECG changes or positive response to stress test;

               2. Cerebral vascular disease, cerebral infarction, intracerebral hemorrhage
                  (excluding intracerebral hemorrhage associated with other diseases); transient
                  ischemic attack (TIA) with carotid artery ultrasound confirming atheromatous
                  change with more than 70% blockage;

               3. Peripheral atherosclerosis with symptoms of ischemia and confirmed by Doppler
                  ultrasound or angiography in history.

          3. Control subjects: Age, gender-matched healthy adults without dyslipidemia and
             atherosclerotic diseases will be recruited as control subjects.

        Exclusion Criteria The main exclusion criteria will be hemodynamically significant valvular
        or congenital heart disease, life-threatening malignancy, treatment with immunosuppressive
        agents, or any condition or situation which, in the opinion of the investigator, might be
        not suitable for this registration.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Finnish Tennis Elbow Trial Pilot Study

Eligibility criteria:
Inclusion Criteria:

          1. Clinically diagnosed tennis elbow defined as: Pain on the lateral side of the elbow,
             made worse by pressure applied on the lateral epicondyle of the humerus and during
             resisted extension of the wrist or when making a fist with the elbow joint straight.

          2. Duration of symptoms over 10 months

          3. Age between 35 and 60 years

          4. Ability to fill in Finnish questionnaires

          5. Written informed consent

        Exclusion Criteria:

          1. Earlier fracture or dislocation in the elbow joint area

          2. Earlier surgical treatment of the same elbow joint

          3. Congenital deformity in the elbow

          4. Systemic muscle, tendon, nerve or joint disease

          5. Other problems causing pain the elbow joint:

               1. Pain in the medial epicondyle of the elbow

               2. Pain in the biceps muscle tendon

               3. Painful snapping or crepitus of elbow joint

               4. Instability of elbow joint (table top, posterolateral drawer test)

          6. A passive movement limitation of more than 10 degrees in the elbow joint

          7. Abnormal finding in an elbow joint X-ray. An elbow joint X-ray is a routine
             examination of elbow symptoms.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction