Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of inherited, severe (FVIII:C < 1%) or moderately severe haemophilia A
             (FVIII ≤ 2%)

          -  Any age

          -  Ability to comply with study methods and willingness to participate to the study

          -  Written informed consent.

        FOR THE LOW RESPONDERS COHORT

        - Documented low anamnestic response after FVIII exposure (FVIII inhibitors titre >0.6 and
        < 5 BU/ml tested by Bethesda assay, Nijmegen modification). It will be included in this
        study those patients who have never been submitted to ITI and also those patients who have
        completed ITI with partial success (defined as inhibitors titre >0.6 and < 5 BU/ml and no
        increase in the INH titer > 5 BU over treatment with FVIII)

        INCLUSION CRITERIA FOR THE HIGH RESPONDERS COHORT

          -  Documented high response after FVIII exposure (FVIII inhibitors titre > 5 BU/ml tested
             by Bethesda assay, Nijmegen modification). It will be included in this study those
             patients who are potential candidates to a first or rescue ITI.

          -  Any historical peak ≥ 5 BU

        Exclusion Criteria:

          -  Diagnosis of acquired haemophilia

          -  Diagnosis of inherited mild haemophilia A (FVIII > 2%)

          -  Life expectancy lower than 1 year

          -  Psychiatric illness and any other conditions may impair ability to comply with study
             methods
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Safety and Pharmacokinetics of a Novel Niclosamide Solution in Combination With Camostat

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male or female subjects in good health as determined by past medical history

          -  physical examination, vital signs and safety lab at screening

          -  between 18 to 45 years of age

        Exclusion Criteria:

          -  Significant illness

          -  pregnant or lactating women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient's own account: I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Clinical trial: Optimizing Treatment on Idiopathic Inflammatory Myopathies

Eligibility criteria:
Inclusion Criteria:

          -  Idiopathic inflammatory myopathies

        Exclusion Criteria:

          -  Inclusion body myositis, muscular dystrophies, neoplasia-associated myopathies,
             overlapped myopathies, others myopathies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Cerebellar rTMS for Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  having a diagnosis of essential tremor (ET) based on Movement Disorder Society
             criteria, involving at least one hand.

          -  18 years or above

          -  cognitively eligible to give informed consent of participation in the trial.

        Exclusion Criteria:

          -  Cardiac pace-maker or other implanted magnetic device or having other
             contraindications of performing a routine non-contrast MRI

          -  skin defect at the occipital area preventing placement of a coil

          -  Currently pregnant or plan for pregnancy in the next 6 months

          -  History of seizure

          -  Other comorbid medical conditions capable of producing or enhancing tremor

          -  advanced cardiac, renal, hepatic or other disabling conditions making patient physical
             unable to participate in examination and receiving the intervention

          -  Use of new drugs with potential effect on tremor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Screening for Osteoporosis in General Practice

Eligibility criteria:
Inclusion Criteria:

          -  Patient identified as being at an increased risk of osteoporosis by the data capture
             system

        Exclusion Criteria:

          -  Known osteoporosis.

          -  Patients treated with alendronate.

          -  Patients below 25 years of age.

          -  Bone metastasis.

          -  Terminal disease.

          -  Severe dementia or other disease or condition that is incompatible with participation.

          -  Bone mineral density scan within the past 3 years.

          -  Errors in their ICPC coding that leads to the patient being misclassified as having an
             increased risk of osteoporosis.

          -  Patients not wanting to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of HIP1802 to HGP1705 in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers in the age between 19 and 50 years old.

          -  Body mass index (BMI) in the range of 19 to 28 kg/m2 and weight 55.0kg to 90.0kg.

          -  After fully hearing and understanding the details of this clinical trial, Subjects who
             have willingness to sign of informed consent before the screening.

          -  Subject who are eligible from physical examination, clinical laboratory test by
             investigators judgment.

        Exclusion Criteria:

          -  Gastrointestinal disorders (gastrointestinal ulcers, gastritis, stomach cramps,
             gastro-esophageal reflux disease, Crohn's disease or chronic pancreatitis) or
             gastrointestinal surgery (except for simple cecal or hernia surgery) which may affect
             the safety and pharmacokinetic evaluation of test drug.

          -  Subjects who have a history of hypersensitivity or clinically significant
             hypersensitivity to investigational product or the same component or other drugs
             (aspirin, antibiotics, etc.).

          -  Aspartate aminotransferase and alanine aminotransferase exceed 1.5 times the upper
             limit of normal range from screening laboratory results before randomization.

          -  Subject who continues to drink (21 units / week, 1 unit = 10 g of pure alcohol) within
             a month before the screening visit or who cannot abstain during the hospital stay.

          -  Heavy smoker (>10 cigarettes/day).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of moderate to severe dry eye syndrome with or without Sjögren's syndrome

          -  receiving treatment with topical cyclosporine (Restasis)

          -  experience one or more moderate dry eye-related symptoms, including dryness, foreign
             body sensation, burning, blurred vision, photophobia, and soreness or pain

        Exclusion Criteria:

          -  history of ocular disorder including non-dry eye ocular inflammation, glaucoma,
             contact lens use

          -  trauma or surgery, including punctal plug insertion within the prior 3 months

          -  any uncontrolled systemic disease or significant illness

          -  use of topical ophthalmic medications that could affect dry eye syndrome

          -  pregnancy, lactation, or considering a pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Epidemiology of Hearing Loss in Diabetic and Non-Diabetic Veterans

Eligibility criteria:
Any participants over 21 years of age and under 80 who do not have an end-stage disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Improved Delivery of Cardiovascular Care Through Outreach Facilitation

Eligibility criteria:
Inclusion Criteria:

          -  Men and women over 40 years of age, who meet at least one of the following criteria:

               1. have established cardiovascular disease: Coronary Artery Disease, Cerebrovascular
                  disease (documented stroke and/or TIA), and Peripheral Vascular Disease;

               2. have Diabetes Mellitus;

               3. have Chronic Kidney Disease ;

               4. are at high risk for CVD based on a presence of at least three of the following
                  established cardiovascular risk factors: age (males ≥ 45, females ≥ 55), smoker
                  status, hypertension, and dyslipidemia.

          -  No restrictions will be imposed on the recruitment process; all practices in the
             region will be eligible to participate.

        Exclusion Criteria:

          -  see above
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment