Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Risk of Diabetes in Young Turner Syndrome Patients

Eligibility criteria:
Turner Syndrome Females:

        Inclusion Criteria:

          -  Turner Syndrome confirmed by chromosomal testing

          -  On standard therapy (growth hormone and or estrogen)

        Exclusion Criteria:

          -  Type 1 or Type 2 diabetes

          -  Polycystic Ovarian Syndrome

          -  Pregnancy

          -  On any medications that alter blood sugar

        Healthy Female Controls:

        Inclusion Criteria:

          -  Healthy

        Exclusion Criteria:

          -  Type 1 or Type 2 diabetes

          -  Polycystic Ovarian Syndrome

          -  Pregnancy

          -  On any medications that alter blood sugar
Female
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 22 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Iron Absorption Trial

Eligibility criteria:
Inclusion Criteria:

          -  patients who are eligible for a primary Roux- en -Y gastric bypass and who have no
             pre-existing iron deficiency (serum ferritin between 20-200 micrograms/L)

        Exclusion Criteria:

          -  blood transfusion one month before ans in the study period. The use of iron containing
             nutritional supplements, except our standardized multivitamin supplements. Decreased
             function of the kidney with a GFR of < 30ml/min and a serum creatinin below 50
             micromol/L. Hb< 7.4 mmol/L in females en Hb< 8.4 mmol/L in males. Accumulation of
             iron. Hypersensitivity for ons of the medicinal products. Psychiatric illness.
             Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis

        Exclusion Criteria:

          -  WOMAC less than 4

          -  Use of braces

          -  Uncontrolled hypertension

          -  Significant psychiatric or psychotic disorder

          -  Not able to attend 75% of sessions

          -  Any other reason that would prevent participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Cardioneuroablation for Reflex Syncope

Eligibility criteria:
Inclusion Criteria:

          -  At least one documented spontaneous VVS during preceding 12 months or one syncope in
             history leading to injury and minimum 2 presyncopal events during preceding 12 months,
             refractory to all recommended types of standard treatment.

          -  In case of lack of ECG documentation during spontaneous syncope and history suggesting
             reflex syncope, at least 3 seconds of asystole due to sinus arrest or
             atrio-ventricular block with syncope or bradycardia <40 beats per minute with syncope
             or presyncope during baseline tilt test

          -  Sinus rhythm during ECG and tilt test

          -  Significantly decreased quality of life due to syncope

          -  Positive response to atropine test

          -  Obtained written informed consent.

        Exclusion Criteria:

          -  Other possible and treatable causes of syncope such as significant cardiac disease,
             cardiac arrhythmia or abnormalities of vertebro-basiliar arteries

          -  History of stroke or TIA

          -  History of cardiac surgery

          -  Contraindications to ablation in the right or left atrium
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo

Eligibility criteria:
Inclusion Criteria:

          -  Subject is male or female aged 18 to 80 years inclusive.

          -  Subject with papulopustular rosacea (11 to 40 papules or pustules) and an IGA of
             moderate or severe.

          -  For subjects using medications to treat a concurrent medical condition, type and dose
             must have been stable for at least 90 days prior to study entry.

        Exclusion Criteria:

          -  Female subjects who are pregnant, nursing or planning a pregnancy during the study.

          -  Subject has any other active dermatological condition on the face that may interfere
             with the conduct of the study.

          -  Subject uses or has recently used any medication which may interfere with the
             absorption, distribution, or elimination of study medications, or may interfere with
             the assessments of efficacy or safety of the study medications.

          -  Subject has a known allergy to any of the components of the study products, and/or a
             known hypersensitivity to tetracyclines or metronidazole.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Tablet-based Cognitive Training

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Alzheimer's Disease

          -  Patients with increased risk for developing dementia

          -  Must be able to give their consent

        Exclusion Criteria:

          -  Contra-indications for MRI scanning

          -  Substance abuse

          -  Severe medical conditions
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: School Intervention With Daily Physical Activity and Healthy Food for Students With an Intellectual Disability.

Eligibility criteria:
Inclusion Criteria:

          -  mild/moderate intellectual disability

          -  students at the upper secondary schools for intellectual disability students

        Exclusion Criteria:

          -  severe intellectual disability

          -  obesity related syndromes

          -  major physical disabilities
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 22 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Boys age ≥7 years with DMD confirmed clinically and by mutation analysis able to
             undergo cardiac magnetic resonance (CMR) without sedation

          -  LV EF ≥45% (+/-5%) by clinically-acquired echocardiography, nuclear scan or cardiac
             MRI done within 2 weeks of enrollment

        Exclusion Criteria:

          -  Non-MR compatible implants

          -  Severe claustrophobia

          -  Gadolinium contrast allergy

          -  Kidney disease

          -  Prior use of or allergy to aldosterone antagonist

          -  Use of other investigational therapy.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: CoViD-19 Patient in Reims University Hospital in March to April 2020

Eligibility criteria:
Inclusion Criteria:

          -  Patient hospitalized for CoViD-19 infection during the health crisis, in a short-stay
             service of Reims University Hospital and included in Covid-19 Cohort

          -  Age > 18 years

          -  Patient who benefit from the national health insurance coverage

          -  patient agree for participation (consent form signed)

        Exclusion Criteria:

          -  Patient protected by law
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: The Effects of Direct Context Reactivation During Sleep on Memory

Eligibility criteria:
Inclusion Criteria:

        ---

        Exclusion Criteria:

        Participants with a history of neurological disorders or of sleep disorders will be
        excluded.

        Participants who do not believe they would be able to fall asleep in the lab will be
        excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis

Eligibility criteria:
Inclusion Criteria:

          -  Eligible participants included patients ≥20 years with either overweight (BMI of 25-30
             kg/m2) or obese (BMI > 30 kg/m2), who had undergone panendoscopy due to typical
             clinical symptoms of either acid regurgitation, heartburn sensation, or both. By the
             results of panendoscopy, patients with the severity of grade A or B esophageal reflux,
             according to the Los Angeles classification, are enrolled.

        Exclusion Criteria:

          -  Patients are excluded if they have taken antisecretory agents, including histamine-2
             receptor antagonist and PPI, within two weeks prior to the panendoscopy. The following
             conditions are also excluded: the presence of peptic ulcers, pregnancy, major medical
             problems (including hypertension, liver cirrhosis, COPD, asthma, renal failure and
             congestive heart failure), or previous gastric surgery. Patients who have an allergy
             history to dexlansoprazole or lansoprazole are also excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Contradiction