Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A Study of S5G4T-1 in the Treatment of Papular-Pustular Rosacea

Eligibility criteria:
Inclusion Criteria:

          1. Patient must sign an Institutional Review Board (IRB) approved written informed
             consent for this study.

          2. Male and female 18 years of age and older.

          3. Patients must have clinical diagnosis of moderate to severe rosacea.

          4. Have a minimum total of 15.

          5. Have two nodules or less .

        Exclusion Criteria:

          1. Females, who are pregnant, breastfeeding, or planning a pregnancy within the period of
             their study participation or were found to have positive pregnancy test at baseline or
             screening visits.

          2. Presence of more than 2 facial nodules or any nodule greater than 1 cm.

          3. Current or past ocular rosacea (e.g., conjunctivitis, blepharitis, or keratitis) of
             sufficient severity to require topical or systemic antibiotics.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: A Study of the Expression of Nogo and Reticulon Genes in Skeletal Muscle of Patients With Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients with definite ALS

          -  Males or females

          -  Age > 18

        Exclusion Criteria:

          -  Patients with other neuromuscular affections
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Reduced Port Laparoscopic Gastrectomy for Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.

          2. Eastern Cooperative Oncology Group performance status of 0 or 1.

          3. Adequate organ function.

        Exclusion Criteria:

          1. Patients had distant metastasis.

          2. oesophageal invasion of more than 3 cm.

          3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.

          4. Previous chemotherapy or radiation therapy for any other malignancies.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Enhancing the Effectiveness of Physical Therapy for People With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  40 years of age or older

          -  Meet the American College of Rheumatology (ACR) clinical criteria for a diagnosis of
             knee OA. The ACR clinical criteria for knee OA includes knee pain plus 3 of the
             following 6 criteria:

          -  age > 50 years,

          -  morning stiffness of < 30 minutes,

          -  crepitus on active movement,

          -  tenderness of the bony margins of the joint,

          -  bony enlargement of the joint noted on exam,

          -  lack of palpable warmth of the synovium. Based on this criteria, a subject who is less
             than 50 years but has knee pain and 3 of the other 5 criteria would also be classified
             as having knee OA.

        Exclusion Criteria:

          -  do not meet the ACR clinical criteria for knee OA,

          -  are scheduled for total knee arthroplasty (TKA) surgery,

          -  have undergone TJA surgery on any lower extremity joint,

          -  exhibit uncontrolled hypertension (i.e. individuals not currently taking medication
             for hypertension whose systolic blood pressure is greater than 140 mm Hg or diastolic
             blood pressure greater than 90 mm Hg at rest),

          -  have complaints of low back pain or other lower extremity joint pain that affects
             function at the time of recruitment,

          -  have a history of neurological disorders that would affect lower extremity function
             (stroke, peripheral neuropathy, parkinson's disease, multiple sclerosis, etc.),

          -  are women who are pregnant.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: LC-NMR Study Biomarkers to Detect Lung Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a new lesion in the lung

        Exclusion Criteria:

          -  a prior diagnosis of cancer in the past

          -  Not fasted for at least 6 hours

          -  Plasma glucose concentration ≥ 200 mg/dl

          -  Intake of medication at the day of investigation

          -  History/treatment of cancer in the previous 5 years
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects.

Eligibility criteria:
Inclusion Criteria:

          -  BMI between ≥18 kg/m² and <30 kg/m² at time of screening

          -  Body weight between ≥45 kg and <100 kg

          -  Baseline vWF:Ag between ≥60% and <170% (0.6-1.7 IU/mL)

        Exclusion Criteria:

          -  History of and/or any sign or symptom indicating current abnormal hemostasis or blood
             dyscrasia, including but not limited to thrombocytopenia, thrombocytopathy,
             thromboasthenia, hemophilia, von Willebrand's disease, vascular purpura, bleeding gums
             and/or frequent nose bleeding, easy/spontaneous bruises, meno- or metrorrhagia,
             history of gastrointestinal bleeding or excessive bleeding after minor injury such as
             shaving.

          -  Family history of congenital vascular malformation (e.g., Marfan's Syndrome) and/or
             bleeding disorder (e.g., hemophilia, von Willebrand's disease, Christmas disease)

          -  Any surgical intervention (including tooth extraction) or trauma within the 4 weeks
             preceding screening for the study or any planned surgical intervention during the
             participation in the study

          -  Treatment with vitamin K, direct oral anticoagulant (DOAC), warfarin, high dose
             heparin within 2 weeks before screening
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Nasal LPS Challenge in Healthy Volunteers

Eligibility criteria:
INCLUSION CRITERIA

          -  Males and females aged 18 to 60 years

          -  Current non-smokers for last 6 months (<5 cigs per week), with a smoking history of <5
             pack years

          -  BMI 20-30 kg/m2

        EXCLUSION CRITERIA

          -  History of allergy

          -  Upper airway infection in 2 weeks before screening

          -  Lower respiratory tract infection in past 3 months

          -  Treatment with local or systemic corticosteroids during previous 2 months

          -  Signs or symptoms of chronic rhinitis, hypertrophy of turbinates, major septum
             deviation, nasal polyposis or recurrent sinusitis

          -  Previous nasal or sinus surgery

          -  Clinically significant cardiovascular, hepatic, GIT, renal, endocrine, infective,
             haematological, neurological, dermatological, neoplastic conditions,
             gastro-oesophageal reflux, depression, TB

          -  Participation in a therapeutic drug trial in the prior 30 days.

          -  Medical therapy other than that permitted for contraception.

          -  Positive pregnancy test

          -  Inability or unwillingness to use contraception if the patient is a female of
             child-bearing age.

          -  History of drug abuse or urine test showing evidence of recreational drug abuse
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Study of SelfFit Mobile Medical App for Hearing Loss Diagnostics and Hearing Device Fitting / Fine Tuning

Eligibility criteria:
Inclusion Criteria:

          -  Hearing loss at the better ear between 35dB and 50dB (PTA1/2/4)

          -  Active lifestyle

          -  No language problems

          -  No medical contra-indications

          -  Age: between 18 and 75 years

          -  About 50% experienced users and 50% new users

          -  Willing to participate in the trial with one three hour visit to the AMC.

        Exclusion Criteria:

          -  Conductive hearing loss in the middle ear

          -  Severe hearing loss
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of Tegaserod Alone and in Combination With Omeprazole Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sGERD)

Eligibility criteria:
Inclusion Criteria:

          -  History of physician diagnosed GERD

          -  Heartburn and Regurgitation 3 Days during the week prior to screening

        Exclusion Criteria:

          -  History of erosive esophagitis, Barrett's esophagus, esophageal stricture,
             scleroderma, Zollinger-Ellison Syndrome, known primary disorder

          -  History or presence of infection or inflammation of the small or large intestine,
             gastrointestinal malignancy, history of upper GI surgery

          -  Use of PPI during the last four weeks prior to screening

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          1. Patients clinically & histopathologically diagnosed to be suffering from oral lichen
             planus.

          2. Patients who had symptoms i.e. pain and/or burning sensation secondary to oral lichen
             planus.

          3. Patients not on any treatment for the same. In case they were, then such treatment was
             stopped and a washout period of two weeks was given.

        Exclusion Criteria:

          1. Patients suffering from any systemic disease/s like

          2. Patients with any other mucosal disease or any other skin disease which may be
             associated with oral lesions.

          3. Patients on any drug therapy which may cause lichen planus like lesions.

          4. Patients with findings of any physical or mental abnormality, which would interfere
             with or be affected by the study procedure.

          5. Patients with a known allergy or contraindication to study medications
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction