Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Strength Training in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of DMD confirmed by

               1. clinical history with features before the age of five

               2. physical examination

               3. elevated serum creatine kinase level

               4. absence of dystrophin expression, as determined by immunostain or Western blot
                  (<2%) and/or DNA confirmation of dystrophin mutation.

          -  Age 7 to 10.5 years: a lower age limit of 7 years was selected, since in our
             experience children younger than 7 years are likely unable to cooperate and comply
             with all of the exercise measures as needed. An upper age limit of 10.5 years has been
             set as boys with DMD tend to reach a rapid progression into a late ambulatory phase
             soon after this age.

          -  Ambulatory at the time of the first visit, defined as the ability to walk for at least
             100 m without an external assistive device and able to climb four stairs.

          -  Currently using corticosteroids (prednisone or deflazacort) as prescribed by a
             physician.

        Exclusion Criteria:

          -  Contraindication to an MR examination (e.g. aneurysm clip, severe claustrophobia,
             magnetic implants)

          -  Presence of a condition in control subjects or a secondary condition in boys with DMD
             that impacts muscle function or muscle metabolism (e.g. myasthenia gravis, endocrine
             disorder, mitochondrial disease)

          -  Secondary condition leading to developmental delay or impaired motor control (e.g.
             cerebral palsy)

          -  Secondary condition that impacts muscle function or muscle metabolism (e.g. myasthenia
             gravis, endocrine disorder, mitochondrial disease)

          -  Unstable medical condition (e.g. uncontrolled seizure disorder)

          -  Behavioral problems causing an inability to cooperate during testing
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment