Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Phase IV Study to Investigate the Effect of Testosterone Treatment on Paraoxonase Level in Male Patients With Hypogonadotrophic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Volunteers patients with hypogonadism

        Exclusion Criteria:

          -  Coronary heart disease

          -  Other pituitary/hypothalamic disorders or other non-hypogonadism diseases

          -  None was receiving vitamins, lipid-lowering drugs, or other medications known to
             interfere with PON1 activity, lipid profile, or gonadal function
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Does Dairy Benefit Bone & Body Composition in Overweight Girls Undergoing a Weight Management Program?

Eligibility criteria:
Inclusion Criteria:

          -  at or above the age appropriate cut-offs for overweight (OW) or obese (OB) on WHO
             growth charts: ≥85-97% for OW and >97% for OB for BMI

          -  between 10 and 18 years old

          -  menarcheal

          -  low dairy consumers (0-2 svgs/d and <700 mg Ca/d measured by baseline FFQ)

          -  otherwise healthy (i.e. no diagnosed disease or illness)

          -  lower levels of physical activity (0-2 times/week)

          -  no allergy to dairy foods or diagnosed lactose intolerance

          -  not on medications related to a chronic condition or that affect bone health

        Participants will be excluded from participation in the study if they do not meet one or
        more of the above inclusion criteria.
Female
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          1. All patients ages 30-80 with chronic painful knee osteoarthritis who would undergo
             treatment by genicular nerve radiofrequency ablation.

          2. Knee pain for at least 6 months.

          3. Kellgren-Lawrence knee osteoarthritis of 2 or greater.

          4. Pain resistant to conventional therapy including NSAIDs, opioids, muscle relaxants,
             oral steroids, physical therapy, and intra-articular injection therapy.

          5. No pain referral beyond the expected distribution for knee osteoarthritis.

        Exclusion Criteria:

          1. NRS pain score of 4 or more

          2. Focal neurologic signs or symptoms.

          3. Previous radiofrequency ablation treatment for similar symptoms.

          4. Intra-articular knee corticosteroid or hyaluronic acid injection in the past 3 months.

          5. Concomitant radicular pain.

          6. Previous knee surgery.

          7. Patient refusal.

          8. Lack of consent.

          9. Active systemic or local infections at the site of proposed needle and electrode
             placement.

         10. Coagulopathy or other bleeding disorder, current use of anticoagulants or
             anti-platelet medications.

         11. Allergy to medications being used for injection procedures (contrast, local
             anesthetic).

         12. Inability to read English, communicate with staff, or participate in follow-up.

         13. Pregnancy.

         14. Pacemaker.

         15. Cognitive deficit.

         16. Unstable medical or psychiatric illness.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Does Yoga Done To Women With Premenstrual Syndrome Affect Inflammation Parameters?

Eligibility criteria:
Inclusion Criteria:

          -  Being in the age range of 18-35

          -  To be of reproductive age,

          -  Not giving birth before, Healthy women with regular menstrual periods (those who have
             bleeding between menstrual cycles for 3-8 days for 21-35 days),

          -  To be an undergraduate student,

          -  AcOG PMS criteria (according to ACOG diagnostic criteria; women with at least one
             premenstrual syndrome and symptoms in at least three consecutive cycles)

        Exclusion Criteria:

          -  Having a regular yoga history for 3 months before and during the workout;

          -  Having a chronic disease (Endocrine, DM, Heart diseases, psychiatric illness) Oral
             contraceptive use

          -  To have a physical problem that prevents him from doing yoga asanas

          -  Over cyst and PICOS

          -  Get a score lower than 110 from the total scale score according to the PMS scale score

          -  Over 10 in Beck Depression Inventory, Students with a history of gynecological surgery
             were excluded from the study.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Bone Adaptation to Impact Loading

Eligibility criteria:
Inclusion Criteria:

          -  Random population-based sample of women:

               -  Age 35-40 yr

               -  residing in the city of Oulu, Finland

               -  in March 2002

        Exclusion Criteria:

          -  cardiovascular, musculoskeletal, respiratory, or other chronic diseases that might
             limit training and testing

          -  diseases or medication affecting the bone

          -  pregnancy and breastfeeding

          -  regular current or previous participation in impact-type exercises and long-distance
             running more than three times a week
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Clinical Phenotype Based Individualized Prophylaxis in Chinese Hemophilia A Children

Eligibility criteria:
Inclusion Criteria:

          1. Severe hemophilia A (FVIII: C<2%),

          2. Age 1-7y

          3. Historical bleeding in any knee, elbow and ankle joint (s),

          4. >50 EDs irrespective of FVIII product, including human coagulate factor and
             recombinant factor VIII

          5. No inhibitor present or history/family history,

          6. On-demand or low-dose prophylaxis (the dose per kg.week less or as Step 1 prophylaxis
             regimens factor consumption)

          7. Regular clinical visit with accessible data,

          8. Informed consent will be obtained from patient legal guardians before the enrollment.

        Exclusion Criteria:

          -  1. Other bleeding disorders or systemic disorders, or don't fit for enrollment
             according to the investigator, 2. FVIII inhibitor development:>0.6 BU (confirmed by
             two separate tests), 3. Unable to follow the protocol or refuse to continue the
             participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Sequential Treatment of Postmenopausal Women With Primary Osteoporosis (FP-001-IM)

Eligibility criteria:
Inclusion Criteria:

        Women above the age of 50 years with the diagnosis of postmenopausal primary osteoporosis
        may be enrolled in the trial if the following inclusion/exclusion criteria apply.

        All inclusion criteria must be answered "yes" for a subject to be enrolled in the trial.

          1. Has the subject given informed consent according to local requirements before any
             trial related activities? (A trial related activity is any procedure that would not
             have been performed during the routine management of the subject).

          2. Is the subject above 50 years old?

          3. Is the subject postmenopausal (more than 5 years) - in the judgement of the
             investigator?

          4. Does the subject have primary osteoporosis with a lumbar spine T score < -3.0 SD (at
             lumbar spine L1-L4, with a minimum of two evaluable vertebrae)?

          5. Does the subject have a life expectancy of >3 years?

          6. Is the subject able to self-inject PTH (1-84), (or to have PTH (1-84) injection by a
             helper)?
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: The Effect of TASH in Patients With HOCM

Eligibility criteria:
Inclusion Criteria:

          -  LV wall thickness ≥ 15 mm in one or more myocardial segments that is not explained by
             loading conditions

          -  LVOT gradients ≥ 30 mmHg at rest and/or ≥ 50 mmHg at Valsalva's maneuver or exercise

          -  NYHA ≥ III

        Exclusion Criteria:

          -  < 18 years

          -  Fertile women who do not use anti-contraceptives

          -  Pregnancy

          -  Patients are allowed to have a pacemaker (eg. an implantable cardioverter
             defibrillator (ICD)) but cannot be pace-dependent

          -  Amiodarone treatment

          -  Persistent or permanent atrial fibrillation/flutter

          -  Previous SRT

          -  Alcohol or drug abuse

          -  Significant co-morbidity (judged by the investigator)

          -  Patients who cannot give valid consent (e.g. mental illness or dementia) or who do not
             understand Danish.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Health Care Workers' Perception of Patient Safety During COVID-19 Pandemic

Eligibility criteria:
Inclusion Criteria:

          -  Healthcare professionals from all disciplines

          -  Technicians from all disciplines (health related)

          -  Working in a face-to-face manner during the pandemic in the services of health
             institutions

          -  Professional or technical personnel in charge of the quality and patient safety
             processes in the institutions.

        Exclusion Criteria:

          -  Professional or technical staff from the administrative areas
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of idiopathic hypogonadotropic hypogonadism or Kallmann Syndrome

          -  mean testosterone level less than 300 ng/dl

          -  stable weight for the previous 3 months (no weight change greater than or equal to 10
             lbs)

          -  normal serum TSH

          -  normal serum prolactin levels

        Exclusion Criteria:

          -  Type 2 diabetes mellitus

          -  history of diabetes in parents

          -  sleep apnea

          -  bleeding disorder

          -  seeking fertility

          -  2 or more cardiovascular risk factors: smoking, hypertension, diabetes, dyslipidemias,
             family history of cardiovascular disease before age 60.

          -  history of previous cardiovascular event: myocardial infarction, unstable angina,
             cerebro-vascular accident.

          -  illicit drug use/alcohol use (>4 drinks per day)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment