Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Mobile Informatics Solution to Aid in Memory

Eligibility criteria:
Inclusion criteria for PWMC are as follows:

          -  English speaking

          -  a physician diagnosis of early-stage Alzheimer's disease or mild-to-moderate cognitive
             impairment

          -  no history of serious mental illness (i.e., any major psychiatric disorder)

        Inclusion criteria for care partners of PWMC are as follows:

          -  English speaking

          -  21 years of age or over

          -  self-identifies as someone who provides assistance to the PWMC because of their memory
             loss (these individuals are called ''care partners,'' as these individuals may or may
             not provide the intensive hands-on care typical of ''caregivers'')

          -  plans to remain in the area for at least 6 months in order to reduce loss to follow-up

          -  indicates a willingness to use the smartwatch system

        Exclusion Criteria for PWMC are as follows:

          -  non-English speaking

          -  no physician diagnosis of early-stage Alzheimer's disease or mild-to-moderate
             cognitive impairment

          -  a history of serious mental illness (i.e., any major psychiatric disorder)

        Exclusion criteria for care partners of PWMC are as follows:

          -  non-English speaking

          -  under 21 years of age

          -  does not identify as someone who provides assistance to the PWMC because of their
             memory loss

          -  does not plan on remaining in the area for at least 6 months

          -  does not indicate a willingness to use the smartwatch system
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment