Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Value of 25 mcg Cortrosyn Stimulation Test

Eligibility criteria:
Inclusion Criteria:

          -  hypothalamic-pituitary-adrenal disorders

        Exclusion Criteria:

          -  under 18 or older than 65 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
             evidenced by medical history, at the time of signing the informed consent.

          2. Must have been on prophylactic FVIII replacement therapy for at least 12 months prior
             to study entry.

          3. Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
             days (EDs).

          4. No previous documented history of a detectable FVIII inhibitor, and results from a
             Bethesda assay or Bethesda assay with Nijmegen modification of less than 0.6 Bethesda
             Units (BU) on 2 consecutive occasions at least one week apart within the past 12
             months.

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid.

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Significant liver dysfunction.

          4. Prior liver biopsy showing significant fibrosis.

          5. Evidence of any bleeding disorder not related to hemophilia A.

          6. Platelet count of < 100 x 10^9/L.

          7. Creatinine ≥ 1.5 mg/dL.

          8. Liver cirrhosis of any etiology as assessed by liver ultrasound.

          9. Chronic or active hepatitis B.

         10. Active Hepatitis C.

         11. Active malignancy, except non-melanoma skin cancer.

         12. History of hepatic malignancy.

         13. History of arterial or venous thromboembolic events.

         14. Known inherited or acquired thrombophilia, including conditions associated with
             increased thromboembolic risk, such as atrial fibrillation.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: The Validation Process for Confirmation of the French Version of the Pediatric Quality of Life Inventory :PedsQLTM.

Eligibility criteria:
Inclusion Criteria:

          -  Boys aged 7 to 18, with genomic Duchenne muscular dystrophy whose parents (mother and
             / or father) or direct grandparents do not oppose.

        Exclusion Criteria:

          -  Inability for the child to understand the issues

          -  Absence of direct parents or grandparents

          -  Child receiving antidepressant treatment

          -  Non French speaking child

          -  Duchenne Muscular Dystrophy girls
Male
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Azoospermia Patients

Eligibility criteria:
Inclusion Criteria:

          -  at least three semen evaluations performed on separate occasions, when the seminal
             specimen after centrifugation showed no sperm under the microscope and was then
             diagnosed according to several clinical parameters；

        Exclusion Criteria:

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: FODMAPs and Refractory GERD

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18

          -  Affiliation to French Social Security

          -  Informed written consent

          -  RDQ score > 3

          -  Abnormal pH-impedance monitoring on PPI twice daily (since 3 months) according to
             normal values published by Zerbib et al (CGH 2013)

        Exclusion Criteria:

          -  Pregnancy or breast feeding

          -  Women of childbearing potential without an effective method of contraception

          -  Person under guardianship

          -  History of thoracic of abdominal surgery (excepted appendectomy and cholecystectomy)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Inhibitor Development in Patients With Hemophilia A Undergoing Surgery

Eligibility criteria:
Inclusion Criteria:

          -  Males with mild/moderate hemophilia A (fVIII activity 1-40%)

          -  Planned surgical intervention which is anticipated to require 5 consecutive days of
             fVIII replacement therapy (These can be outpatient or inpatient treatment days.)

          -  Weight >22.5 kg (To assure that volumes of blood to be drawn for study purposes are
             safe.)

        Exclusion Criteria:

          -  Past history of an inhibitor (inhibitor titer >0.4 BU/ml)

          -  HIV infection with CD4 count <400/ul

          -  Currently receiving immunosuppressive medication(s)

          -  Unable to tolerate quantity of blood to be drawn

          -  Current or past diagnosis autoimmune disorder

          -  Current or past diagnosis of immune deficiency disorder other than HIV
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices

Eligibility criteria:
Inclusion Criteria:

          -  Health volunteers 18 years and above; equal numbers of males and females to address
             Sex As a Biological Variable (SABV); and in sinus rhythm.

          -  Agree to commit to participate in the current protocol.

          -  Provide written informed consent prior to any study procedures being performed (all
             subjects should be able to understand the informed consent form and any other
             documents that subjects are required to read).

        Exclusion Criteria:

          -  Unable or unwilling to provide informed consent

          -  Any other condition that would increase the risk of participation in the study in the
             opinion of the site Investigator.

          -  A difference of >10 mm Hg in left versus right arm oscillometric systolic BP.

          -  Upper extremity arteriovenous hemodialysis shunt.

          -  Wrist distortion or pain from arthritis.

          -  Prior trauma or surgery at the radial artery monitoring site.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough

Eligibility criteria:
Inclusion Criteria:

          -  Adults (age > 18 years) seeking care for an acute respiratory illness (duration < 10
             days) in which cough is a chief complaint.

          -  Eligible patients will be required to have at least 1 symptom of acute respiratory
             tract infection (fever, night sweats, rhinorrhea, sinus congestion, myalgias).

        Exclusion Criteria:

          -  Previous (within 21 days) antibiotic treatment;

          -  immunodeficiency;

          -  cystic fibrosis;

          -  patient requiring immediate evaluation/management;

          -  inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants

Eligibility criteria:
Inclusion Criteria:

          1. Able and willing to provide written informed consent.

          2. Males ≥18 years of age.

          3. Clinically severe hemophilia A

          4. Previous exposure to FVIII therapy

          5. No prior history of hypersensitivity or anaphylaxis associated with an FVIII or
             intravenous immunoglobulin administration.

          6. No measurable inhibitor against FVIII

          7. Willing to participate and receive treatment in a future Spark hemophilia A gene
             therapy study.

        Exclusion Criteria:

          1. Documented active hepatitis B or C within the past 12 months of Screening

          2. Currently on antiviral therapy to treat hepatitis B or C;

          3. Documented significant liver disease within the past 6 months of Screening

          4. Have serological evidence of HIV-1 or HIV-2

          5. Anti-AAV-Spark 200 neutralizing titers ≥1:1

          6. Previously received SPK-8011;

          7. Previously dosed with any investigational or approved gene therapy product at any time
             or treated with an investigational drug within the last 12 weeks;

          8. Planned surgical procedure in the next 12 months requiring FVIII prophylactic
             treatment.

          9. Any history of chronic infection or other chronic disease, concurrent clinically
             significant major disease (such as liver abnormalities or type I diabetes) including
             active malignancy, except for non-melanoma skin cancer, any other condition or any
             other unspecified reasons that, in opinion of the Investigator or Sponsor, makes the
             participant unsuitable for participation and dosing in a future clinical study for
             Spark's hemophilia A gene therapy.

         10. Unable or unwilling to comply with the schedule of visits and/or study assessments
             described in the protocol.
Male

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Portuguese Inguinal Hernia Cohort (PINE) Study

Eligibility criteria:
Inclusion Criteria:

          -  Elective inguinal hernia repair in a portuguese hospital

          -  Willing and able to consent and comply with the follow up protocol

        Exclusion Criteria:

          -  Urgent/emergent inguinal hernia repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment