Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Granulocyte Colony-stimulating Factor on Clinical Pregnancy Rate in Patients With Endometriosis

Eligibility criteria:
Inclusion Criteria:

          -  Cases of infertility, older than 20 years of age and not older than 40 years.

          -  Body mass index (BMI): 20-29.

          -  Women diagnosed with endometriosis (diagnosis based on ultrasound or laparoscopy or
             both)

          -  Recurrent implantation failure (failure to conceive following two embryo transfer
             cycles, or cummulative transfer of >10 good quality embryos)

          -  Normal ovulatory cycles (as proven by folliculometry and/or mid luteal serum
             progesterone), good ovarian reserve (as proven by early follicular FSH and AMH)

          -  Normal uterine cavity as assessed by ultrasonography, hysterosalpingography, or
             hysteroscopy

          -  Normal hormonal profile (serum PRL, TSH, thyroid hormone)

          -  Normal semen analysis of the partner

          -  Infertility after one year of unprotected intercourse

          -  High-quality embryos were transplanted

        Exclusion Criteria:

          -  Congenital or acquired uterine abnormalities (e.g. septate, bicornuate, fibroid
             uterus, uterine polyp & Asherman Syndrome)

          -  Congenital or acquired tubal abnormalities (e.g. hydrosalpinx or pyosalpinx)

          -  Contraindication for G-CSF (renal disease, sickle cell disease, or malignancy history,
             upper respiratory tract infection, pneumonia, or chronic neutropenia)

          -  Thrombophilia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Evaluation of the Predictors of Clinical and Radiological Response to Gamma-Knife Radiosurgery in the Treatment of Intermediate Ventral Nucleus of the Thalamus (VIM) Thalamotomy Tremor.

Eligibility criteria:
Inclusion Criteria:

          -  Male or female aged 20 years minimum

          -  Patient with absolute contraindication or relative to deep brain stimulation (DBS) of
             VIM.

          -  Patient having the Gamma Knife radiosurgery of VIM (combining clinical and
             paraclinical conditions).

          -  Patient affiliated to a social security scheme.

          -  Patient having understood and signed the information notice for non opposition.

        Exclusion Criteria:

          -  Patient having a contraindication to performing a cerebral MRI (pace-maker,
             intracerebral metallic object etc.)

          -  Patient with a contraindication to radiosurgical treatment (previous treatment with
             cerebral radiotherapy)

          -  Vulnerable persons: minors, protected adults (guardianship or trusteeship) and adults
             unable to express their non-opposition.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Hernia Repair Four Arm Comparative Study

Eligibility criteria:
Inclusion Criteria:

          -  adult male primary inguinal hernia

        Exclusion Criteria:

          -  recurrent hernia previous lower abdominal surgery [excluding appendectomy]
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Study Investigating PK, PD, Efficacy, Safety, and Immunogenicity of Biosimilar Denosumab (GP2411) in Patients With Postmenopausal Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women, diagnosed with osteoporosis

          -  Aged ≥ 55 and ≤ 80 years at screening

          -  Body weight ≥ 50 kg and ≤ 90 kg at screening

          -  Absolute bone mineral density consistent with T-score ≤ -2.5 and ≥ -4.0 at the lumbar
             spine as measured by DXA

          -  At least two vertebrae in the L1-L4 region and at least one hip joint are evaluable by
             DXA

        Exclusion Criteria:

          -  Previous exposure to denosumab (Prolia, Xgeva, or biosimilar denosumab)

          -  History and/or presence of one severe or more than two moderate vertebral fractures or
             hip fracture

          -  History and/or presence of bone metastases, bone disease or metabolic disease

          -  Ongoing use of any osteoporosis treatment or use of prohibited treatment

          -  Other bone active drugs

          -  History and/or current hypoparathyroidism or hyperparathyroidism, hypocalcemia or
             hypercalcemia

        Other Inclusion/exclusion criteria may apply
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Performance Proof of Product Developed to Detect Abnormal Vaginal pH

Eligibility criteria:
Inclusion Criteria:

          1. Women, age 18 years or greater with or without symptoms of vaginal infection.

          2. Subject is ready to sign the informed consent form.

        Exclusion Criteria:

          1. Subject is unable or unwilling to cooperate with study procedures.

          2. Subject is currently participating in another clinical study.

          3. Subject suffers from vaginal bleeding or is menstruating.

          4. Subject that have had sexual relations within the last 12 hours.

          5. Subject that applied local antiseptic or antibiotic or vaginal treatment within the
             last 3 days.

          6. Subject that applied vaginal douching within 12 hours prior to the visit at the
             clinic.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: ADX10059 as a Monotherapy in Patients With Gastroesophageal Reflux (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of typical GERD

          -  well controlled on a standard clinical symptoms controlled dose of PPI treatment

          -  body mass index ≤32 kg/m2

        Exclusion Criteria:

          -  exclusively atypical symptoms of GERD

          -  symptoms that have been shown not to be associated with GERD

          -  erosive oesophagitis

          -  hiatus hernia > 3 cm

          -  current diagnosis of co-existing psychiatric disease

          -  known clinically significant allergy or known hypersensitivity to drugs

          -  pregnant or breast-feeding

          -  has received sodium valproate or topiramate within 30 days of Screening

          -  has a history of a significant medical condition that may affect the safety of the
             patient or preclude adequate participation in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Frozen Embryo Transfer on Cycle Outcomes

Eligibility criteria:
Inclusion Criteria:

          1. Patients with history of one fresh embryo transfer failure

          2. Patients with Primary infertility

          3. Patients with at least one embryo with excellent quality

        Exclusion Criteria:

        1. Female age over 40 years old 2- Severe male factor (Azoospermia) 3- Endometriosis
        diagnosis and the presence of hydrosalpinges 4- Uterine factor ( polyps, myoma and previous
        myomectomy, …) 5- Patients with polycystic ovarian syndrome diagnosis 6- Cases with
        pre-implantation genetic diagnosis (PGD)indication 7- Cases with difficult embryo transfer
        or use of Tenaculum 8- Patients with repeated implantation failures and repeated
        miscarriages. 9- Female smokers
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Gastroesophageal Reflux Disease Prospective Registry

Eligibility criteria:
Inclusion Criteria:

        - Any patient undergoing anti-reflux surgery

        Exclusion Criteria:

        - None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Physical Activity and Daily Experiences Study

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 or older

          -  English literate

          -  A BMI ranging from 25-40 (overweight or obese), based on self-report height and weight

          -  Not meeting current national physical activity guidelines

          -  Self-report they are able to walk unassisted, without the help of a wheel chair,
             walker, cane, crutches, or other walking aids

          -  Medically cleared to participate by completing screening form

          -  For women: not currently pregnant or actively trying to get pregnant for duration of
             study

        Exclusion Criteria:

          -  Younger than 18

          -  Not English literate

          -  Self-report they are unable to walk unassisted, without the help of a wheel chair,
             walker, cane, crutches, or other walking aids

          -  A BMI outside of inclusion range (<25 or >40), based on self-report height and weight

          -  Meeting current national physical activity guidelines

          -  Not medically cleared to participate

          -  For women: currently pregnant or actively trying to get pregnant for duration of
             study. Pregnant women or those trying to become pregnant will be excluded because
             pregnancy may interfere with women's ability to go about previously normal activities,
             and will influence our outcome measures (e.g., BMI).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: SIBO & SIFO After Colectomy

Eligibility criteria:
Inclusion Criteria:

        patients who were referred to a specialist motility center over 4 year period with:

          -  Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and
             abdominal discomfort

          -  history of colectomy

          -  patients with no history of colectomy

          -  patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal
             tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase
             antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound
             scan.

          -  patients with glucose breath test and/or duodenal aspirate

        Exclusion Criteria:

          -  patients with upper gut or small bowel surgery

          -  Patients who were hospitalized or with serious cardiac or pulmonary or neurologic
             comorbidities

          -  Patients with intestinal strictures or known intestinal motility disorders such as
             scleroderma or pseudo-obstruction syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction