Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women

Eligibility criteria:
Inclusion Criteria:- Fitzpatrick Skin type I or II

          -  Nonpregnant Females, age 18-30 or 50-70

          -  Body Mass Index Normal or Overweight

          -  If age 18-30, must be non-smoker

          -  Willing to fast for 8 hours prior to a blood draw; Exclusion Criteria:- History of
             cosmetic surgery

          -  Use of anti-aging medications within 3 months of enrollment

          -  Use of over-the-counter anti-aging creams (not sunscreens) more than once per week
             within one month of enrollment

          -  Use of dietary supplements including vitamins within one month of enrollment

          -  Use of tanning beds or excessive UV exposure (greater than 2 hours per day) within one
             month of enrollment

          -  Use of sunless tanners within one month of enrollment

          -  Uncontrolled or ongoing serious medical condition

          -  Participation in another clinical study involving use of an investigational drug or
             product

          -  Medical condition which, at the discretion of the investigator, will have a
             significant impact on ability to judge participant's skin characteristics, including
             age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: CATER: Comprehensive Alveolar and Tooth Esthetic Replacement

Eligibility criteria:
Inclusion Criteria:

          -  At least 18 years of age

          -  Willing and able to provide informed consent

          -  In need of one implant to replace a missing tooth

          -  At least 20 teeth in good repair and occlusion

          -  Sufficient bone volume for dental implant placement without required bone augmentation

          -  Site development (soft and/or bone tissue) performed at least 5 months before implant
             placement, when required

        Exclusion Criteria:

          -  Current smoker

          -  Implant cannot be placed without bone graft

          -  Unable to pay for crown

          -  Untreated rampant caries and/or uncontrolled periodontitis

          -  Absence of adjacent (mesial and/or distal) natural tooth

          -  Uncontrolled diabetes

          -  Systemic or local disease or condition that would compromise post-operative healing
             and/or osseointegration

          -  use of bisphosphonates

          -  History of radiation in the head and neck region

          -  Unable or unwilling to return for follow-up visits

          -  Unrealistic esthetic or functional demands

          -  Unlikely to be able to comply with study procedures

          -  Unwilling or unable to provide informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Chronological age ≥ 3 and chronological or bone age less than or equal to 11 years
             inclusive in girls;

          -  Chronological age ≥ 3 and chronological or bone age less than or equal to 12 years
             inclusive for boys

          -  Prepubertal

          -  Height SD score of < -2

          -  IGF-1 SD score of < -2

        Exclusion Criteria:

          -  Prior treatment with rhGH, rhIGF-1, or other growth-influencing medications

          -  Growth failure associated with other identifiable causes (e.g., syndromes, chromosomal
             abnormality)

          -  Chronic illness such as diabetes, cystic fibrosis, etc.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Extended vs Flexed Elbow Casting

Eligibility criteria:
Inclusion Criteria:

          1. Both bone forearm fractures in which the fracture of the radius and/or ulna is located
             in the proximal one half of the bone

          2. The fracture requires a reduction maneuver

          3. All skeletally immature individuals under the age of 18

          4. Patient aged greater than three years old

          5. Patient or patient's consenting parent/guardian competent in English.

        Exclusion Criteria:

          1. Skeletally mature individuals

          2. Both fractures are located in the distal one-half of the radius and ulna

          3. Isolated fractures of the radius or ulna

          4. The fracture does not require a reduction maneuver

          5. Any nerve or arterial injury in the injured extremity

          6. Humerus fracture on the ipsilateral side

          7. Any open fracture requiring formal surgical debridement

          8. Patient or patient's consenting parent/guardian not competent in English.

          9. Patient or patient's consenting parent/guardian not present.

        9. Severe problems with maintaining follow-up (e.g live in different state) 10.
        Contractures in which applying an extended elbow cast is not possible or practical
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Consequences of Unwanted Pregnancy in Nepal

Eligibility criteria:
Inclusion Criteria:

          -  women

          -  seeking pregnancy termination services at one of the study facilities

          -  self-report last menstrual period to be at least 10 weeks ago or not know her
             gestational age

          -  15 years old or older

          -  live in Nepal

        Exclusion Criteria:

          -  under 15 years old

          -  not pregnant

          -  do not live in Nepal
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination

Eligibility criteria:
Inclusion Criteria:

          -  Amenorrhoea for >= 12 months.

          -  Serum estradiol and FSH level within the postmenopausal range

          -  Baseline endometrial biopsy assessed by light microscopic histological evaluation
             revealing: insufficient endometrial tissue for diagnosis because of insufficient
             available (atrophic) endometrial tissue (not because of an inaccessible cervix) and
             endometrial thickness < 5 mm (double layer) by transvaginal ultrasound, atrophic
             endometrium, secretory endometrium, menstrual type endometrium, proliferative
             endometrium

        Exclusion Criteria:

          -  Previous systemic unopposed estrogen replacement therapy over 6 months or more.

          -  Any estrogen, progestogen, and/or androgen therapy in the last four weeks before
             Screening Visit (Visit 1). The baseline endometrial biopsy should in all cases be
             taken after cessation of the withdrawal bleeding due to previous hormone replacement
             therapy.

          -  History or presence of an estrogen dependent neoplasia (including breast- cancer).

          -  History or presence of malignant neoplasms other than basal or spinal cell carcinoma
             of the skin.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Reduction of Pain Following Laparoscopic Surgery: A Double Blind Prospective Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  All patients were recruited from a single Consultant's surgical clinic at the same
             District General Hospital between August 2010 and February 2012. This study was
             approved by the local ethics committee (National Research Ethics Service REC ref:
             09/H0405/65) and informed consent was obtained from all patients after they had the
             opportunity to study information leaflets that were also given to them. The trial was
             designed as a prospectively randomized and double blind trial with a 1:1
             (control:intervention) allocation.

        The inclusion criteria was all adults with an American Society of Anesthesiologists (ASA)
        physical status grade 1 or 2, who were undergoing elective laparoscopic cholecystectomy for
        gallbladder disease or laparoscopic inguinal hernia repair performed as a transabdominal
        preperitoneal procedure (TAP). All procedures and data collection occurred at a District
        General Hospital.

        Exclusion Criteria:

        The pre-operative exclusion criteria included patients younger than 18 years, those who
        refused to give consent, those that had an inability to understand the research
        questionnaire and pregnancy. Patients who were found to require additional procedures, for
        example a conversion to open surgery, were excluded from the study prior to randomization.

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Modelling of Energy Expenditure From Heart Rate, Accelerometry and Other Physiological Parameters

Eligibility criteria:
Inclusion Criteria:

          -  men and women

          -  age: 18-60 years

          -  BMI between 19 and 25 kg/m²

          -  subject considered as healthy after clinical examination and medical questionnaire

          -  subject giving his/her written informed consent

          -  subject willing to comply with study procedures

          -  affiliated to National Health Insurance

        Exclusion Criteria:

          -  biological results judged abnormal by investigator

          -  positive serologies to HIV or HCV

          -  respiratory failure or cardiovascular problem

          -  taking medicine : beta blockers, corticoids, anti-inflammatory drug, thyroid hormones,
             insulin

          -  abnormal ECG

          -  more than 10% of weight or gain loss in the three last months

          -  tumoral, inflammatory, pulmonary, renal, digestive or liver diseases

          -  surgery made less than 6 months before the study beginning

          -  thyroid disease

          -  pregnant women and nursing mother

          -  insanity

          -  smoker

          -  claustrophobic

          -  no affiliated to national health insurance people

          -  refusal to sign informed consent

          -  refusal to be registered on the national volunteers data file

          -  currently participating or who having got 4500€ in this year before to have
             participated in another clinical trial
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study Evaluating Inhibitor Specificity in Hemophilia A

Eligibility criteria:
Inclusion Criteria:

        · Patients with moderate or severe congenital hemophilia A, a current FVIII inhibitor, who
        have taken at least two different FVIII products during their lifetime.

        Exclusion Criteria:

          -  Patients who have had an inhibitor prior to their current inhibitor.

          -  Patients with immune disorders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment