Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD

Eligibility criteria:
Inclusion Criteria:

          1. atypical GERD symptoms (cough, globus, or NCCP)

          2. with or without typical GERD symptoms (heartburn or acid regurgitation)

          3. A total Reflux Symptom Index (RSI) score ≥13

        Exclusion Criteria:

          1. Patients who currently took pro-kinetic agents, baclofen, antacid, sucralfate,
             histamin-2 receptor antagonists, PPI, antitussive, non-steroid anti-inflammatory
             drugs, anxiolytics, or anti-depressants during screening and during study period

          2. Patients who have severe cardiac, pulmonary, hepatic, or renal diseases

          3. Patients who have uncured underlying malignancy

          4. Patients with laryngeal or pharyngeal disorders

          5. Patients with a history of gastrointestinal (GI) surgery, symptoms of GI tract
             obstruction

          6. Patients with a contraindication for PPI use
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Eligibility criteria:
Inclusion Criteria:

          -  Man or woman

          -  Aged 18 years or older

          -  Subject having signed a free and informed consent

          -  Subject affiliated to a social protection scheme Arm 1 :Subjects with primary
             sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder
             of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric
             pathology pathology with disorder of the controls of the wake and the sleep Arm 4 :
             subject presenting an ophthalmological pathology with possible alteration of the
             photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with
             regulation disorder of sleep and wake Arm 6 : healthy subject

        Exclusion Criteria:

        Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa,
        macular involvement of diabetes)

          -  Cataract with significant vision loss <5/10

          -  Chorioretinal neovascularization

          -  Subject in exclusion period determined by previous or current study

          -  Impossibility to give the subject information enlightened (subject in emergency
             situation, difficulties of understanding the subject, ...)

          -  Subject under the protection of justice

          -  Subject under guardianship or curatorship

          -  Pregnancy / Breastfeeding
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Short Segment Fixation in Thoracolumbar Osteoporotic Fracture

Eligibility criteria:
Inclusion Criteria

          -  osteoporotic burst fracture at a single level of the thoracolumbar region

          -  dual-energy X-ray absorptiometry and T-score value less than -2.5

        Exclusion Criteria

          -  translational displacement at the fracture site (fracture-dislocation)

          -  loss of structural integrity within the posterior osteoligamentous complex (such as
             flexion-distraction ligament disruption)

          -  spondylolisthesis of the adjacent vertebrae

          -  malignancy

          -  chronic steroid administration

          -  previous spinal surgery

          -  prior vertebroplasty and infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Validation of King's Sarcoidosis Questionnaire in a Danish Population

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with sarcoidosis

          -  Signed informed consent

        Exclusion Criteria:

          -  Inability or unwillingness to adhere to the study

          -  Inability to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Efficacy of Eccentric Resistance Training in Persons With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Individuals will be included in the study if they are:

          -  at least 55 years old,

          -  cognitively able to understand directions,

          -  able to ambulate at least 50 feet without stopping,

          -  are currently experiencing knee pain and

          -  meet at least 3 out of 6 criteria of the European League Against Rheumatism (EULAR)
             criteria for knee osteoarthritis diagnosis.

        Exclusion Criteria:

        Individuals will be excluded from the study if they have:

          -  a diagnosed medical condition that would limit physical ability, including acute or
             active fractures, myocardial infarctions, stroke,

          -  a traumatic brain injury within the last 6 months, or

          -  joint replacement within the last 12 months. Individuals with chronic neurological
             disorders limiting motion or present with any known contraindication for balance
             training will also be excluded from the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Endodrill vs. Conventional Biopsy. Evaluation of Diagnostic Capacity in Diffuse Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Patients with suspected or with an established diagnosis of diffuse gastric cancer who
             are capable of stating a formal consent to participate in the study.

        Exclusion Criteria:

          -  Mental illness

          -  Extreme co-morbidity (ASA>3)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Evaluation of Surgical Treatment of Terrible Triade Injury of the Elbow Joint

Eligibility criteria:
Inclusion Criteria:

          -  1.skeletally mature patients (over 17 years old) including both sexes. 2.Acute
             fractures within 3 weeks of injury. 3.Isolated & closed fractures . 4.polytrauma
             trauma patients with no other injuries in the same limb.

        Exclusion Criteria:

          -  1. pathological fracture of proximal radius and ulna. 2. deteriorateed general health.
             3. previous history of dysfunction with the affected elbow.
No condition on gender to be admitted to the trial.

Subject must be at least 17 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Open-Label Study of Diclofenac Capsules to Treat Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  Male or female ≥ [greater than or equal to] 40 years of age

          -  If a participant in the previous DIC3-08-05 study, completed the study and did not
             discontinue for lack of efficacy or safety

          -  Has a diagnosis of OA of the hip or knee with ongoing knee and/or articular hip pain

          -  Is a current chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or
             acetaminophen for his/her OA pain and is anticipated to benefit from continuous
             treatment with therapeutic doses of NSAIDs. A current chronic user is defined as a
             subject who has used these treatments for ≥ [greater than or equal to] 20 days of the
             last 30 days before screening

        Exclusion Criteria:

          -  Has a known history of allergic reaction or clinically significant intolerance to
             acetaminophen, aspirin, or any nonsteroid anti-inflammatory drugs (NSAIDs), including
             diclofenac

          -  Requires chronic use of opioid or opioid combination products to control OA pain of
             the knee or hip

          -  Has any clinically significant unstable cardiac, respiratory, neurological,
             immunological, hematological, or renal disease

          -  Has significant difficulties swallowing capsules or is unable to tolerate oral
             medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Phase 2 Study for the Treatment of Superficial Lipomas

Eligibility criteria:
Inclusion Criteria:

          -  One or more lipomas, based on clinical and histological diagnosis, which are
             accessible for treatment and assessment, are quantifiable along at least 2
             perpendicular diameters, and have the following characteristics:

               -  History of slow growth followed by dormancy, and stable for at least 6 months

               -  Greatest length multiplied by greatest perpendicular width between 1 and 16 cm²,
                  inclusive

               -  Discrete, oval to rounded in shape, not hard or attached to underlying tissue

               -  Without changes in overlying skin (ie, inflammation, pain or tenderness,
                  hyperpigmentation)

               -  Located on the trunk, arms, legs, or neck

          -  Signed informed consent.

        Exclusion Criteria:

          -  Absence of significant medical conditions that could affect safety

          -  History of surgical or deoxycholate treatment for lipomas

          -  Treatment with an investigational agent within 30 days before ATX-101 treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: CA125 Levels and Other Inflammatory Markers in Laparoscopic Ventral Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Adults admitted for ventral or incisional hernia repair

        Exclusion Criteria:

          -  Loss-of-domain

          -  ASA above III

          -  Liver failure

          -  Abnormal CA-125 prior to surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment