Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: A Study to Investigate the Antihypertensive Efficacy of MK0954

Eligibility criteria:
Inclusion Criteria:

          -  Patient has been diagnosed with mild to moderate hypertension (SDBP 95-115 mm Hg)

          -  Patient has no medical problems or treatments that might effect their blood pressure

        Exclusion Criteria:

          -  Pregnant or lactating females

          -  Patient has secondary hypertension or malignant hypertension

          -  Sitting systolic blood pressure > 210 mm Hg

          -  History of stroke

          -  History of myocardial infarction with in past year

          -  Current or prior history of heart failure

          -  Known hypersensitivity to losartan

          -  Prior exposure to losartan

          -  Patients known to be HIV positive

          -  Patient is abusing or has abused alcohol or other drugs within the past 4 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Interventricular Cardiac Septal Thickness in Fetus of Diabetic Mother Correlated to Postnatal Outcome

Eligibility criteria:
Inclusion Criteria:

          -  above 35 weeks pregnancy

          -  diabetic mothers

          -  single intrauterine pregnancy

        Exclusion Criteria:

          -  any other medical disorder
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Relation of Implantation Site to Placental Site in Presence or Absence of Cesarean Section Scar

Eligibility criteria:
Inclusion Criteria:

          -  singleton intrauterine pregnancy.

          -  gestational age less than 10 weeks

          -  history of previous cesarean section(one or more)

        Exclusion Criteria:

          -  negative fetal pole pulsation.

          -  any condition distorting uterine cavity i.e uterine myoma,uterine cavity anomalies

          -  multifetal pregnancy.

          -  any condition necessitate termination of early pregnancy i.e maternal medical disorder
             ,molar pregnancy.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
Ambulant children age 5-10 years with an established diagnosis of Duchenne Muscular
        Dystrophy
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Louisville Teen Pregnancy Prevention Project

Eligibility criteria:
Inclusion Criteria:

          1. Parental Informed Consent for enrollment in the CHAMPS! CAMP and accompanying research
             sessions,

          2. Personal assent for participation in the workshop and research sessions.

          3. Age 14 to 19 years old ;

          4. Affiliation with youth serving organizations, or part of a current foster youth or
             former foster youth alumni group.

        Exclusion Criteria:

          1. Age 13 or younger, 20 or older;

          2. Married

          3. Inability to participate verbally in English;

          4. Cognitive impairment that precludes the subject from giving assent or informed consent
             for any reason;

          5. Refusal of consent to participate in the study by their parent.

          6. Already pregnant or a parent, because we are attempting primary prevention.

          7. Prior participation in a comparable local program, such as Love U2.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 19 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Coping Effectiveness Training for ALS

Eligibility criteria:
PATIENTS:

        Inclusion Criteria:

          1. ALS diagnosis (possible, probable, or definite) in the past year

          2. Expresses distress (4+) on Distress Thermometer, or symptoms of anxiety or depression
             (VAS scales)

          3. Speaks English

          4. Able and willing to give informed consent

          5. Speaks clearly enough for telephone communication

        Exclusion Criteria:

        1. Untreated or under-treated Major Depressive Disorder

        CARE PARTNERS:

        Inclusion Criteria:

          1. Has a family member or close friend diagnosed with ALS (possible, probable, or
             definite) in the past year

          2. Expresses distress (4+) on Distress Thermometer, or symptoms of anxiety or depression
             (VAS scales)

          3. Speaks English

          4. Able and willing to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Comparison of the Efficacy of Rapid Tests to Identify COVID-19 Infection (CATCh COVID-19)

Eligibility criteria:
Inclusion Criteria:

          -  • Male or female over 18 years of age at the time of enrollment

               -  Current symptoms of COVID-19 ; fever alone or fever and at least one of the
                  following symptoms need to be present

                    -  Dry cough

                    -  Sore throat

                    -  Shortness of breath

                    -  Chills

                    -  Muscle pain

                    -  Headache

                    -  New loss of taste or smell

                    -  Chills with repeated shaking

        Exclusion Criteria:

          -  • Unwilling to provide informed consent

               -  Unwilling to undergo bi-weekly serological test during the 1-month enrollment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Prone-position CT for Diagnosing Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  inguinal hernia

        Exclusion Criteria:

          -  emergency surgery for incarcerated hernia

          -  femoral hernia

          -  recurrent inguinal hernia after laparoscopic inguinal hernia repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Physician-Pharmacist Collaboration for Osteoporotic Patient Follow-up

Eligibility criteria:
Inclusion Criteria:

          -  older than 18 years old

          -  having an osteoporosis treatment

          -  following a Therapeutical Education for Patient

        Exclusion Criteria:

          -  opposition for anonymised data gathering
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment

Eligibility criteria:
Inclusion Criteria:

          -  All boys identified in the period from January 1990 to February 2013

        Exclusion Criteria:

          -  Misclassified (other diagnoses)

          -  Insufficient data

          -  Lost to follow up
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism

Eligibility criteria:
Inclusion Criteria: Serum testosterone concentration < 300ng/dL Absence of a pituitary or
        hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

        Exclusion Criteria: Previous androgen treatment, diabetes mellitus, arterial hypertension
        other hormone deficiencies

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD)

Eligibility criteria:
Inclusion Criteria:

          -  Bone age of at least 15 years for girls or at least 16 years for boys within 6 months
             of obtaining the DXA scan

          -  Previous enrollment in the NCGS core study, 85-036

          -  Tanner Stage 4 or greater

          -  Either spontaneous or induced puberty

          -  Subjects who plan on terminating GH treatment for statural purposes for one or more of
             the following reasons: epiphyseal fusion, slowing growth rate indicates that near
             adult height has been reached, or satisfied with current height

        Exclusion Criteria:

          -  Current therapy with a non Genentech GH product

          -  Pregnancy (to avoid exposure to low levels of radiation from DXA scanners)

          -  Bilateral hip replacement

          -  Weight >130 kg (286 lb.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Eligibility (NLI label): Contradiction