Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: To Evaluate Sperm Parameters in Men With Secondary Hypogonadism Previously Treated With Topical Testosterone

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adult males between 21 and 60 years of age who have been diagnosed with AIHH.

          -  Subjects must have been treated with a topical testosterone replacement therapy
             (typically AndroGel® or Testim®) for at least 6 months at enrollment and for not more
             than 2 years.

        Exclusion Criteria:

          -  A history of idiopathic infertility due to primary hypogonadism, testicular failure,
             Kallmann's syndrome or any other infertility condition.

          -  Subjects demonstrating any clinically significant medical condition rendering the
             subjects infertile or marginally fertile other than AIHH.

          -  Men with a history of, known, or suspected prostate disease not ruled out by a
             prostate biopsy, or a prostate specific antigen (PSA)>3.6 or clinical suspicion of
             current prostate disease.

          -  Men with a hematocrit in excess of 50 % or hemoglobin >17 g/dl
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Photorefractive Intrastromal Corneal Crosslinking as a Treatment for Low Grade Myopia

Eligibility criteria:
Inclusion Criteria:

        Spherical equivalent on distance subjective refraction between -0.50D and -2.50D.

          -  Astigmatism ≤ 0.75D

          -  Stable myopia. Maximum change in refraction of 0.50D in the last 2 years.

          -  Best corrected visual acuity of at least 0.00 logMAR (ETDRS chart).

          -  Thinnest pachymetry reading ≥ 440 μm.

          -  No previous ocular surgery.

          -  No cognitive insufficiency interfering with the informed consent.

        Exclusion Criteria:

          -  History of or current condition, disease, surgery or medication with ocular effects
             that could affect the outcomes of the treatment.

          -  Allergy to any substance or device used in the study.

          -  Cognitive insufficiency interfering with the informed consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Cold Application in Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with elbow pain for at least 3 months

          -  those between 20 and 40 years of age

          -  who did not have cold allergies

        Exclusion Criteria:

          -  With a different elbow problem or multiple elbow problems,

          -  having cervical or other upper extremity problems,

          -  elbow joint operation,

          -  tendon rupture,

          -  limited range of motion due to humerus, radius or ulna fracture

          -  individuals with a history of osteoporosis, malignancy, hemophilia, neurological
             effect, and cognitive dysfunction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Prophylactic Alpha-blockers in the Prevention of Urinary Retention Post Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Males of 41 to 80 years old who are going for elective inguinal hernia repair
             (laparoscopic or open) under general anesthesia.

        Exclusion Criteria:

        Patient whom has any of the following will be excluded:

          -  Contraindication to tamsulosin : known allergy, known orthostatic hypotension,
             significant cardiac co-morbidities ( New york heart association functional
             classification >2) or heart failure

          -  End stage renal failure

          -  More than two anti-hypertensive use/long term alpha blockers/beta
             blockers/anticholinergic (eg : buscopan)

          -  Previous urological or pelvic surgery

          -  Known benign prostatic hyperplasia on medications

          -  Long term indwelling catheters

          -  Concurrent neurologic disease such as stroke, poliomyelitis, cerebral palsy, multiple
             sclerosis, spinal lesions, diabetic and alcoholic neuropathy
Male
Accepts Healthy Volunteers
Subject must be at least 41 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: ISSUE3: International Study on Syncope of Uncertain Etiology 3

Eligibility criteria:
Inclusion Criteria:

          -  Suspected or certain neurally-mediated syncope, based on the Guidelines recently
             published by the Task Force on Syncope of the European Society of Cardiology 2,3
             (Appendix 1);

          -  More than 3 syncope episodes in the last 2 years;

          -  Clinical presentation of syncope of sufficient severity requiring treatment initiation
             in the physician's and patient's judgement.

          -  Age > 40 years.

          -  Negative carotid sinus massage.

          -  Patients accept to have an ILR implantation.

        Exclusion criteria:

          -  Carotid sinus hypersensitivity

          -  Suspected or certain heart disease and high likelihood of cardiac syncope:

          -  Symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement;

          -  Loss of consciousness different from syncope (e.g. epilepsy, psychiatric, metabolic,
             drop-attack, TIA, intoxication, cataplexy);

          -  Subclavian steal syndrome;

          -  Psychologically or physically (due to any other illness) or cognitively unfit for
             participation in the study according to the opinion of the investigator;

          -  Patient compliance doubtful;

          -  Patient geographically or otherwise inaccessible for follow-up;

          -  Patient unwilling or unable to give informed consent;

          -  Life expectancy <1 year.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells

Eligibility criteria:
INCLUSION CRITERIA:

        We will review medical records of patients enrolled in NHLBI protocol who are 18 years of
        age or older.

        EXCLUSION CRITERIA:

        This study excludes any subjects younger than 18 years old.

        Female subjects recruited for this study would ideally have no prior history of male
        childbearing or abortion.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children

Eligibility criteria:
Inclusion Criteria:

          -  Group1: Children with GH deficiency diagnosed by 2 provocative tests with peak GH less
             than 10 ng/ml.

          -  Group 2:Children with height less than the 3rd centile without any etiology

          -  Group 3:children with failure to thrive until the age of 3 years.

          -  Group 4: children with obesity defined by BMI above the 90th centile for age and sex.

          -  Group 5: children with no endocrine diseases and without obesity or short stature.

        Exclusion Criteria:

          -  Children with known pediatric or endocrine diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Treatment for Nicotine Addiction in Women

Eligibility criteria:
Inclusion Criteria:

          -  Must be 18yrs to 45yr old woman, read and write in English.

          -  Must smoke at least 5 or more cigarettes a day

          -  FTND score at least 4 or higher

          -  A CO reading of 10 or higher during screening

          -  Must be in good health as verified by medical history, screening exam, screen
             laboratory tests.

        Exclusion Criteria:

          -  Excluded if using psychotropic medications, have contraindications to tolcapone use
             (e.g.. liver problems, allergy to tolcapone, history of no traumatic rhabdomyolysis or
             hyperpyrexia, confusion possibly related to medication), have other substance use
             disorder, are pregnant or breast feeding, have a current psychotic disorder, bipolar
             disorder, homicidal or suicidal ideation, have current (past month) substance use
             disorder, other than nicotine dependence, or are unable to fulfill the scheduled
             visits and procedures.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Effect of High-dose Naloxone Infusion on Pain and Hyperalgesia in Patients Following Groin-Hernia Repair.

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years and ≤ 65 years

          -  Signed informed consent

          -  Patients submitted to unilateral, primary inguinal, open herniotomy 6-8 weeks prior to
             study start.

          -  Open operating procedure a.m. Lichtenstein.

          -  Urin sample without traces of opioids (morphine, methadon, buprenorphine, codeine,
             tramadol, ketobemidone, oxycodone, hydromorphine, dextromethorphan)

          -  ASA I-II

          -  Body mass index (BMI): 18 < BMI < 30

        Exclusion Criteria:

          -  Volunteers , who do not speak or understand Danish

          -  Patients, who cannot cooperate with the investigation

          -  Patients who have had previous surgery in the groin region

          -  Patients with pain at rest > 3 (NRS)

          -  Activity-related pain in the surgical field > 5

          -  Allergic reaction against morphine or other opioids (including naloxone),

          -  Abuse of alcohol or drugs - according to investigator's evaluation

          -  Use of psychotropic drugs (exception of SSRI)

          -  Neurologic or psychiatric disease

          -  Chronic pain condition

          -  Regular use of analgesic drugs

          -  Skin lesions and tattoos in the assessment areas

          -  Nerve lesions in the assessment sites (for instance, after trauma, disc herniation,
             etc.)

          -  Use of prescription drugs 1 week before the trial

          -  Use of over-the-counter drugs 48 hours before the trial
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction