Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A Study of the Effects of a Novel Ovarian Stimulation Regimen on Embryo Aneuploidy Rates in In Vitro Fertilization (IVF)

Eligibility criteria:
Inclusion Criteria:

          -  Female age ≤ 37 years

          -  BMI 18-29 kg/m2

          -  Regular cycle (25-35 days)

          -  Standard indication for IVF

          -  No major uterine abnormalities

          -  Written informed consent

        Exclusion Criteria:

          -  Indication for IVF male factor with a total motile sperm count < 20x106

          -  ICSI or andrological indication

          -  Known abnormal (male or female) karyotype

          -  Oocyte donation

          -  One previous IVF treatment not resulting in embryo transfer

          -  History of recurrent abortion

          -  Medical contra indication for pregnancy or IVF treatment

          -  Relevant systemic disease

          -  Active substance abuse
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: A Swiss Study With Atorvastatin in Hyperlipidemic Patients Measuring LDL-Cholesterol

Eligibility criteria:
Inclusion Criteria:

          -  Risk factors and diagnosis of dyslipidemia according to the AGLA-recommendations (see
             appendix B) at screening

          -  LDL-C < 6.0 mmol/l

          -  Triglyceride level < 5.0 mmol/l.

        Exclusion Criteria:

          -  Subjects receiving higher than "usual maintenance" doses of Lipid Lowering Therapy
             (LLT) at screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: ADVANCE Study: Alzheimer Disease eVAluation iN Clinical PracticE

Eligibility criteria:
Inclusion Criteria:

          -  Age 50 and older

          -  Diagnosis of dementia

          -  Rating 15<MMSE<24

          -  The patient has reliable caregivers

          -  Signed consent form to participate in the study after informed by reliable caregivers
             of the patient or another witness

          -  The patient is on treatment with donepezil for at least one month prior to joining the
             clinical trial

        Exclusion Criteria:

          -  Severe gastrointestinal, kidney, hepatic, endocrine, pulmonary, or hematologic
             disease.

          -  Other primary psychiatric or neurological disorder.

          -  Clinically significant laboratory and ECG abnormalities.

          -  Participation in another clinical study than this

          -  Refusal to sign the consent form to participate in the study after informed by
             reliable caregivers of the patient or another witness

          -  The patient is on treatment with donepezil for less than a month before its
             integration in the clinical study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: A Study to Evaluate Growth in Participants Treated With Somatropin (Nutropin) Using NuSpin Device

Eligibility criteria:
Inclusion Criteria:

          -  Bone age less than or equal to (</=) 8 years (females) or </= 10 years (males) as
             determined by x-ray of the left hand and wrist obtained within six months before
             enrollment

          -  Prepubertal males and females by physical exam

          -  Naive to rhGH therapy

          -  Diagnosis of IGHD or ISS by standard pharmacologic testing and no other discernable
             etiology for short stature

          -  Height standard deviation score (Ht SDS) </= -1.5 (</= 5th percentile) for IGHD
             participants; Ht SDS </= -2.25 (</= 1.2 percentile) for ISS participants

        Exclusion Criteria:

          -  Short stature etiologies other than IGHD or ISS

          -  Participants receiving chronic corticosteroid therapy (greater than [>] 3 months) for
             other medical conditions

          -  Participants with active malignancy or any other condition that the investigator
             believes would pose a significant hazard to the participant if rhGH were initiated

          -  Females with turner syndrome

          -  Any previous rhGH treatment

          -  Participation in another simultaneous medical investigation or trial

          -  Pediatric participants with closed epiphyses

          -  Participants prescribed rhGH doses outside the variance of NCGS control participant
             dosing
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Applicability of Syncope Guidelines in Cataluña

Eligibility criteria:
Inclusion Criteria:

          -  Each patient that comes from the Emergency room and/or in office doctors visit
             (Internal Medicine, Cardiology, Neurology...) with Transient Loss of Conscience
             (T-LOC)

        Exclusion Criteria:

          -  Patients younger than 15 years old

          -  Pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Strattice in Repair of Inguinal Hernias

Eligibility criteria:
Inclusion Criteria:

          -  adult male

          -  symptomatic and palpable inguinal hernia

          -  open, elective, primary unilateral inguinal hernia repair

        Exclusion Criteria:

          -  bilateral inguinal hernia repair

          -  BMI >35

          -  chronic immunosuppression, active chemo/radiation therapy, uncontrolled diabetes,
             severe liver disease or COPD

          -  chronic prostatitis, orchitis, testicular pain

          -  local or systemic infection at time of repair

          -  known collagen disorder

          -  chronic pain syndrome or under active pain management
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Anal Dilatation for Infants and Children With Constipation

Eligibility criteria:
Inclusion Criteria:

          1. Infants and Children With Constipation

          2. Postoperative infants and children with Hirschsprung's disease

          3. Good compliance

        Exclusion Criteria:

          1. Infants and Children With Constipation

          2. Poor compliance
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 14 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effects of Strength Training on Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Males and females 60 to 100 years of age

        Exclusion Criteria:

          -  Knee joint replacement surgery

          -  Diabetes mellitus

          -  Uncontrollable hypertension

          -  Neuropathies of the lower extremity

          -  Poor mental cognition (i.e., inability to follow instructions)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Bimanual Uterine Compression to Reduce Blood Loss and Prevent Postpartum Haemorrhage After Vaginal Delivery

Eligibility criteria:
Inclusion Criteria:

          1. Gestational age more than 28 weeks the gestational age was determined based upon the
             date of the first day of last normal menstrual period and confirmed by ultrasound scan
             during the 1st trimester

          2. Women at high risk for primary atonic postpartum hemorrhage

               -  Over distended uterus

               -  Large fetus

               -  Multiple fetuses

               -  Hydramnios

               -  Distension with clots accidental hemorrhage

               -  Exhausted myometrium

               -  Prolonged labor

               -  Oxytocin or prostaglandin stimulation

               -  Chorioamnionitis

               -  Previous uterine atony

               -  Placenta previa

               -  Marked anemia

        Exclusion Criteria:

          1. Cervical tear

          2. extensive birth canal tear

          3. Postpartum hemorrhage

          4. Retained placenta

          5. Coagulopathy

          6. Chronic medical illness hepatic renal

          7. Pregnancy induced hypertension PIH

          8. Refusal to participate in the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Tele-Pharmacy Intervention to Improve Treatment Adherence

Eligibility criteria:
Inclusion Criteria:

          -  Filled and poorly adherent (defined as a PDC < 80%) to medication for hyperlipidemia,
             hypertension, or diabetes

          -  Suboptimal average adherence to all of the qualifying medications that a patient has
             filled (defined as combined (average of averages) PDC < 80%)

          -  For patients with hypertension or diabetes, poor or worsening disease control
             (according to relevant clinical targets)

        Exclusion Criteria:

          -  Patients with <6 months of continuous enrolment in the health plan

          -  Patients with no available contact information
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment