Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Dydrogesterone in the Treatment of Endometrial Polyps

Eligibility criteria:
Inclusion Criteria:

          1. women of childbearing age from 20 to 50 years old

          2. with or without menstrual changes:

               1. menostaxis (longer than 7 days)

               2. shortened menstrual cycles(less than 23 days)

               3. menorrhagia(more than twice as much as usual)

               4. abnormal vaginal bleeding(non-menstrual vaginal bleeding)

          3. with following signs of vaginal ultrasound in the follicular phase (day 1 to day 10 of
             a menstrual cycle):

               1. typical signs with a suspect of EP: (median/high) echo with a regular contour
                  within the uterine lumen;

               2. atypical signs with a suspect of EP: punctate cystic areas within the endometrium
                  and the endometrial thickness >1cm;

        Exclusion Criteria:

          1. no menses within half a year;

          2. surgery or drug treatment of endometrial lesions in the past half year;

          3. with current intrauterine device;

          4. combined with other acute gynecological inflammation;

          5. with clinically suspected malignant tumors;

          6. long-term use of oral contraceptives;

          7. with abnormal liver and kidney function;

          8. with benign or malignant breast tumors;

          9. with any systemic malignant tumor or a history of tumors;

         10. participants who are pregnant.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Phase 2a Study on Intravenous Infusion of Autologous Osteoblastic Cells in Severe Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of severe osteoporosis

          -  Non-response to anti-osteoporotic treatment for over 2 years

          -  Normal hematology function

          -  Ability to provide a written, dated, and signed informed consent prior to any study
             related procedure, and to understand and comply with study requirements

        Exclusion Criteria:

          -  Positive serology for hepatitis B, hepatitis C, HIV, syphilis, HTLV-1

          -  Current or past medical disease that could interfere with the evaluation of the
             efficacy, as judged by the investigator

          -  Severe renal or hepatic impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Exploring the Immunology of Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

          1. Males or females, of any race, between 18 and 85 years of age, inclusive

          2. Able to provide written informed consent

          3. Clinician diagnosis of sarcoidosis

          4. Treatment-naïve or receiving immunomodulatory therapy.

        Exclusion Criteria:

        1. Evidence of acute bacterial infection or other condition likely in the opinion of the
        investigator to significantly impact results of blood assays.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Assessment of Endometrial Thickness & Subendometrial Perfusion by 3D Power Doppler in Women With Unexplained Infertility and PCOS.

Eligibility criteria:
Inclusion Criteria:

          -  • Inclusion criteria of study group (1&2):

               1. Women with primary or secondary infertility for more than 1 year due to
                  unexplained infertility (normal regular menstrual cycles and normal pelvic
                  examination, evidence of ovulation by TV/US and/or normal mid-luteal serum
                  progesterone, normal semen analysis of the husband according to WHO guidlines2010
                  (25), and evidence of tubal patency and normal uterine cavity by HSG and/or
                  laparoscopy).

               2. Women with PCOS according to Rotterdam ASRM/ESHRE criteria(26) • Inclusion
                  criteria for control group (2):

               1. Women with no history of menstrual dysfunction or subfertility.

               2. Normal regular cycles and normal pelvic examination.

               3. Multipara with last delivery since ≥ 2 years with no history of abortions and not
                  on contraception (hormonal or IUD).

        Exclusion Criteria:

          -  • Exclusion criteria of both groups:

               1. History of pelvic surgery or pelvic inflammatory disease.

               2. Current hormonal contraception.

               3. On IUD.

               4. History of or clinical features suggesting endometriosis or pelvic pathology like
                  uterine fibroid and ovarian cyst.

               5. General medical disorders (e.g. D.M), smoking and lactation.
Female




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Quality of Life in Hemophilia by Clinical Scoring System (FISH)Score

Eligibility criteria:
Inclusion Criteria:

          -  congenital Hemophilia A and B patients more than 18 years old

        Exclusion Criteria:

          -  All hemophilia patient less than 18 years old

          -  Patients with other bleeding disorders

          -  Patients with other comorbidities that can affect joint function as collagen disease

          -  Patients on steroids or non-steroidal analgesics
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study of Oral Bacteria in Patients With Dry Mouth

Eligibility criteria:
Selection of subjects for the study will be restricted to the pool of NIDCR patients
        already participating in protocol 84-D-0056, Evaluation and Treatment of Salivary
        Dysfunction.

        INCLUSION CRITERIA

        A. Salivary Flow = 0.1ml/min pooled unstimulated; and

        B. A diagnosis of SS (primary or secondary)

        C. A diagnosis of non-SS auto-immune disease

        D. The use of a medication with known xerostomic effect

        E. Subjective xerostomia or xerophthalmia

        F. The presence of permanent teeth.

        EXCLUSION CRITERIA

        A. Child and Adolescent:

        Children and Adolescents will not be included in the study due to the presence of deciduous
        teeth which are less suitable for bonding and which show an altered enamel morphology and
        pattern of plaque accumulation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: The Effects of Trunk Exercises on Upper Extremity and Respiratory Functions in DMD

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with Duchenne Muscle Dystrophy

          -  No injuries and no neurological or orthopedic surgery in the last 6 months

          -  No other systemic or orthopedic / neurological disorders to prevent exercise

        Exclusion Criteria:

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis

Eligibility criteria:
Inclusion Criteria:

        Postmenopausal women who meet at least one of the following bone mineral density (BMD) and
        fracture criteria:

          -  BMD T-score at the total hip or femoral neck of ≤ -2.50 and EITHER:

               -  at least 1 moderate (semiquantitative grade [SQ]2) or severe (SQ3) vertebral
                  fracture OR

               -  at least 2 mild (SQ1) vertebral fractures OR

          -  BMD T-score at the total hip or femoral neck of ≤ -2.00 and EITHER:

               -  at least 2 moderate (SQ2) or severe (SQ3) vertebral fractures OR

               -  a fracture of the proximal femur that occurred within 3 to 24 months prior to
                  randomization.

        Exclusion Criteria:

          -  History of metabolic or bone disease (except osteoporosis)

          -  Use of agents affecting bone metabolism

          -  Vitamin D insufficiency

          -  History of solid organ or bone marrow transplants

          -  Hyper- or hypocalcemia

          -  Hyper- or hypothyroidism

          -  Hyper- or hypoparathyroidism

          -  Possible signs of intolerance to alendronate
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: UPLC-MS/MS Monitoring of Emicizumab Therapy

Eligibility criteria:
Inclusion Criteria:

          -  Adult or child with Clinical diagnosis of severe hemophilia A (FVIII activity < 1%)
             with or without inhibitor

          -  Clinical indication to emicizumab therapy

        Exclusion Criteria:

          -  Refusal to give informed consent

          -  acquired hemophilia A

          -  other inherited or acquired bleeding disorder

          -  bodyweight < 10 kgs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: DBS in the Treatment of Intractable Movement Disorders

Eligibility criteria:
Inclusion Criteria:

          1. Dopa responsiveness

          2. Minimum disease duration of 5 years.

          3. Diagnosis of idiopathic Parkinsons disease

          4. Patients with intractable Essential Tremors.

          5. Patients with intractable dystonia

        Exclusion Criteria:

          1. Significant medical health problems.

          2. Significant cognitive impairment

          3. Bleeding tendencies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment