Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Medico-economic Evaluation of Different High-throughput Sequencing Strategies in the Diagnosis of Patients With Intellectual Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Patients (children and adults) with intellectual deficiency (ID), whatever the degree

          -  Absence of a clear clinical diagnosis at the first consultation for the dysmorphology
             assessment

          -  Patients who have never undergone genetic investigations

          -  Consent of the patient or his/her legal representative

          -  Patient with national health insurance cover

          -  Samples available from both parents

        Exclusion Criteria:

          -  Pregnant or breast-feeding women

          -  Patients presenting learning disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Efficacy of Denosumab Treatment in Bisphosphonate Unresponsive Patients

Eligibility criteria:
Inclusion Criteria:

          -  Being a woman with postmenopausal osteoporosis

          -  Being between the ages of 45-85

          -  Using bisphosphonate therapy for at least two years

          -  Vertebral and/or Femur T score below -2.5

          -  Unresponsive to bisphosphonate therapy

               -  More than 2% decrease in BMD values despite using bisphosphonates and/or

               -  New major fracture development during treatment

        Exclusion Criteria:

          -  Male gender

          -  Being extremely thin (BMI <15) or extremely obese (BMI> 45)

          -  Malignancy

          -  Severe chronic liver and kidney failure

          -  Chronic Steroid use

          -  Having an active rheumatic disease

          -  Having other secondary causes of osteoporosis (primary hyperparathyroidism etc.).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: SS-INQ Information Needs Questionnaire in Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients with a diagnosis of primary SS as per the 2002 American-European
             Consensus Group (AECG) classification criteria, or

               -  Adult patients with a diagnosis of primary SS as per the 2016 American College of
                  Rheumatology/European League Against Rheumatism classification criteria

               -  Adults with the capacity to consent to their involvement in the study

               -  Willingness to participate in focus groups

               -  Fluency in the English language to allow participation in focus group discussion

               -  Willingness to complete the newly developed questionnaire on at least on occasion

        Exclusion Criteria:

          -  Patients with SS who have developed lymphomatous chang
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage

Eligibility criteria:
Inclusion Criteria:

          -  over 18 years of age healthy no contraindication to medical treatment visible fetal
             structures such as yolk sac or fetus

        Exclusion Criteria:

          -  empty gestational sac more than sparse bleeding or dilated cervix mental instability
             after diagnosis contraindication to medical treatment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I

Eligibility criteria:
Inclusion Criteria:

          -  Males or females in generally good health at least 40 years of age

          -  Osteoarthritis (OA) of at least one knee, verified by a weight-bearing radiograph

          -  Subject has taken an oral NSAID or analgesic at least 3 days during the past 30 days
             to treat knee OA pain

        Exclusion Criteria:

          -  Females who are pregnant or lactating or who may become pregnant

          -  Hypersensitivity (exacerbations of asthma, rhinitis, or urticaria) to sulfonamides,
             acetaminophen, diclofenac, celecoxib, aspirin, or any other NSAID

          -  History of myocardial infarction, congestive heart failure, stroke, coronary-artery
             bypass graft surgery, or any other significant cardiovascular disease, or is on any
             form of anticoagulation therapy other than low-dose aspirin (no more than 325 mg/day)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Study of Hypertrophic Cardiomyopathy Under Stress Conditions. Concordance Between Two Complementary Tests: Stress MRI and Exercice Stress Echocardiography

Eligibility criteria:
Inclusion Criteria:

          -  The patient is adult (> or = 18 years) and informed.

          -  He's agree for a 24-month follow-up.

          -  The patient must be member or beneficiary of a health insurance system.

          -  He must have a clear diagnosis of HCM defined by a left ventricular hypertrophy in
             tranthoracic echocardiography (superior to 15mm or 13mm if there is a familial
             history) without other causes of hypertrophy (severe hypertension, aortic stenosis,
             amyloidosis or fabry disease, ..)

        Exclusion Criteria:

          -  The patient is under safeguarding justice, tutorship or curatorship.

          -  The patient formalizes his opposition.

          -  It's impossible to give enlightened information.

          -  The patient doesn't read French.

          -  The patient is pregnant or breastfeeding.

          -  Contraindication to the realization of a MRI (defibrillator, no-MRI compatible PMK,
             claustrophobia,..)

          -  Contraindication to the Persantine° injection (asthma, high degree block, ..)

          -  Contraindication or impossibility to realize a stress echocardiography.

          -  Comorbidity that can be responsible of the studied anomalies: coronaropathy,
             myomectomy, multicomplicated diabetes, …
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: MIROCALS: Modifying Immune Response and OutComes in ALS

Eligibility criteria:
Main Inclusion criteria

          -  Patient is 18 years old and less than 76 years old

          -  Possible, Probable, Probable laboratory-supported or Definite ALS as defined by El
             Escorial Revised ALS diagnostic criteria

          -  Disease duration <= 24 months

          -  Slow Vital capacity >= 70% of normal

          -  No prior or present riluzole treatment

          -  Lumbar punctures accepted by patient and done

        Main Exclusion criteria

          -  Other neurodegenerative disease that could explain signs or symptoms

          -  Contra indication for lumbar puncture (history of allergy to xylocaine, presence of
             contra-indicated treatment, or coagulation test abnormality, clinically significant
             coagulopathy or thrombocytopenia)

          -  Non authorized treatment

          -  Other disease or disorders that could preclude functional assessment, or
             life-threatening disorders

          -  Any documented, active, past or present, auto-immune disorders except asymptomatic
             Hashimoto thyroiditis

          -  Using assisted ventilation

          -  Feeding through gastrostomy or nasogastric tube

          -  Women of child-bearing potential or sexually active man without contraception

          -  Pregnant or breast feeding woman

          -  Any clinically significant laboratory abnormality (excepting cholesterol,
             triglyceride, glucose, CK, ferritin)

          -  History of documented symptomatic and treated asthma within the past 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Paravertebral Block for Inguinal Hernia Repair in Elderly

Eligibility criteria:
Inclusion Criteria:

          -  patients admitted to undergo elective unilateral inguinal hernia repair

          -  patients with ASA II, III or IV

        Exclusion Criteria:

          -  bilateral inguinal hernia

          -  incarcerated hernia

          -  emergency cases

          -  known history of allergic reactions to local anesthesia

          -  bleeding disorders

          -  neurological disorders

          -  infection at site of injection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Ambulatory Laparoscopic Inguinal Hernioplasty: Feasibility and Cost Analysis

Eligibility criteria:
1. Inclusion Criteria:

               -  Patients older than 18 years old

               -  Laparoscopic inguinal hernioplasty as the pincipal surgery

          2. Exclusion Criteria:

               -  Patients with, high anesthetic risk (decompensated ASA III and ASA IV)

               -  Morbid obesity (higher BMI 40),

               -  Sleep apnea with indication of use of CPAP (Continuous Positive Airway Pressure)

               -  Medicated psychiatric disease,

               -  Drug-dependent patient

               -  Patients with an inadequate social environment-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment