Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: The Study of Rest Tremor Suppression by Using Electrical Muscle Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  For PD patients

               -  Adults ≥ 18 years old.

               -  Patients with Parkinson's disease diagnosed according to the UKPDSBB criteria
                  with predominantly feature of rest tremor that intractable to medically
                  treatment.

               -  Informed consent For other tremor patients

               -  Adults ≥ 18 years old.

               -  Patients with essential tremor diagnosed according to the TRIG criteria for
                  essential tremor or patients with dystonic tremor diagnosed according to the
                  proposed definition in which their symptoms shared similar trait of medically
                  intractable tremor.

               -  Informed consent

        Exclusion Criteria:

          -  For PD patients

               -  Patients with a history of cardiac arrhythmia, renal failure, hepatic failure,
                  and pregnancy as well as those who had history of seizure or had the risk for
                  tended to become seizure such as those who had focal brain lesions, encephalitis,
                  and stroke patients.

               -  Patients with a history of hand surgery and implanted screws or wires in hand
                  area that supposed to place a surface EMG or EMS, as well as those patients who
                  were implanted for electrical devices such as cardiac pacemaker, pulse generator
                  of deep brain stimulation,and intrathecal baclofen pump.

               -  Patients who cannot avoid the medication that may potentiate or attenuate tremor
                  such as antihistamines, benzodiazepine, illicit drugs, and thyroid hormone
                  supplement.

        For other tremor patients

          -  Patients with a history of cardiac arrhythmia, renal failure, hepatic failure, and
             pregnancy as well as those who had history of seizure or had the risk for tended to
             become seizure such as those who had focal brain lesions, encephalitis, and stroke
             patients.

          -  Patients with a history of hand surgery and implanted screws or wires in hand area
             that supposed to place a surface EMG or EMS, as well as those patients who were
             implanted for electrical devices such as cardiac pacemaker, pulse generator of deep
             brain stimulation, and intrathecal baclofen pump.

          -  Patients who cannot avoid the medication that may potentiate or attenuate tremor such
             as antihistamines, benzodiazepine, illicit drugs, and thyroid hormone supplement.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment