Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Study About Lymphocytes Change During Menstrual Cycle in Women of Child-bearing Age

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 20-49;

          -  Having a regular menstrual cycle of which the menstrual period is between day 3-7, and
             the period between day 25-35;

          -  Excluding internal and surgical disease (after having variety of physical examination
             such as electrocardiogram/hepatic and renal function/blood routine and urine routine).

        Exclusion Criteria:

          -  Having experienced severe allergies, trauma history and/or operation history within 3
             months;

          -  With a history of mental illness and/or family history of mental illness;

          -  Limb disabled;

          -  Taking medicine within one month;

          -  Suffering major events or having mood swings.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Randomized Controlled Trial Assessing the Efficacy of Lianhua Qingwen as an Adjuvant Treatment in Patients With Mild Symptoms of COVID-19

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥21 years

          2. Positive laboratory test for COVID-19 by RT-PCR methods

          3. Presenting with at least one symptom (symptoms include fever, dry cough, sore throat,
             nasal congestion, malaise, headache, muscle pain, anosmia, and diarrhoea)

          4. Length of time between date of onset of symptoms and the date of recruitment should
             not exceed 5 days to ensure that trial participants are in the early stages of
             infection

          5. No clinical or radiographic evidence of pneumonia

          6. Able to provide informed consent

        Exclusion Criteria:

          1. Individuals with underlying primary diseases such as cardiovascular, respiratory,
             liver, renal, diabetes, hepatitis A/B/C, gout or endocrinological diseases and
             neurological disorders which put them at a higher risk of developing severe disease

          2. Individuals with compromised immune systems such as malignant tumors, organ or bone
             marrow transplants, HIV, or have taken immunosuppressants in the past three months.

          3. Women who are pregnant or on lactation.

          4. Individuals with mental illness.

          5. History of allergy to any drug or food, or herb ingredient observed in this trial.

          6. Individuals who are deemed not able to comply with trial procedure or follow-up
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes

Eligibility criteria:
Inclusion Criteria:

        - primary Addison's disease in combination with long-standing Type 1 diabetes

        Exclusion Criteria:

          -  cardiovascular disease

          -  active malignant disease

          -  pregnant women

          -  pharmacological treatment with glucocorticoids or drugs that interfere with cortisol
             metabolism (antiepileptics, rifampicin, St. Johns war, estrogens)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia

Eligibility criteria:
Inclusion Criteria: Infertile men with azoospermia on at least two semen analyses separated
        by at least one week, and no pregnancy with partner with normal cycles and normal
        hysterosalpingogram despite >1 year of unprotected intercourse.

        -

        Exclusion Criteria: hypogonadotropic hypogonadism (that might respond to gonadotropin
        injections); use of anabolic steroids,illicit drugs, or consumption of more than 4
        alcoholic beverages daily; current therapy with retinoic acid (eg Accutane) or vitamin A-
        of use of isotretinoin within eight weeks of start of dosing;phenytoin, or medication
        containing tetracycline; personal history of serious psychiatric disorders, score of
        greater than 15 on the PHQ9 (mood) questionnaire; elevated serum serum triglycerides or
        other abnormal serum chemistry values; history of inflammatory bowel disease or bone
        disease; not living within catchment area; participation in another clinical trial

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Design and Implementation of a Nutritional Intervention in Patients With Oropharyngeal Dysphagia

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Oropharyngeal Dysphagia.

          -  Patients who have primary caregiver.

          -  Agreeing to participate in the study.

        Exclusion Criteria:

          -  Critically ill patients.

          -  Chronic kidney disease with Glomerular Filtration Rate <30 ml / min or in renal
             replacement therapy

          -  Liver failure.

          -  Cancer with active radiotherapy or chemotherapy treatment.

          -  Patients who are participating in another study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: The Stork OTC: Collection, Placement & Delivery

Eligibility criteria:
Inclusion Criteria:

          -  Literacy must be in English (able to understand Informed Consent)

          -  In general good health

          -  Heterosexual, monogamous couples, of any race or ethnicity, who are sexually active
             (as a couple)

          -  18 - 50 years of age

          -  REALM-SF Test Results demonstrate 6th grade literacy or above

          -  Past experience with using condoms

          -  Trying to conceive or using a non-vaginal birth control with which they do not
             normally use a condom.

          -  Signed Informed Consent

        Exclusion Criteria:

          -  Vaginal prolapsed (female)

          -  Hysterectomy (female)

          -  Erectile Dysfunction (male)

          -  Colposcopy with biopsy surgery within the last three (3) months (female)

          -  Treatment for dysplasia surgery within the last three (3) months (female)

          -  Vaginal/cervical surgery within the last three (3) months (female)

          -  Current Pregnancy (female)

          -  Unable to read and understand English
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Platelet Rich Plasma vs Open Surgery in the Treatment of Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

        Any patient who:

          -  Has experienced more than 6 months of symptoms from tennis elbow (pain on the lateral
             elbow that radiates down the forearm, point tenderness over the origin of the extensor
             muscles or at its close proximity (within 2.5cm) and pain on resisted extension of the
             Wrist).

          -  Patients must also have failed conservative treatment (a course of physiotherapy and
             activity modification)

          -  Baseline elbow pain >3/10 on VAS during resisted elbow extension.

        Exclusion Criteria:

          -  Presence of a full tendon tear on pre-intervention ultrasound

          -  Unfit for surgical intervention

          -  Have undergone previous elbow surgery,

          -  Have previously undergone PRP injection therapy

          -  Systemic autoimmune rheumatological disease

          -  Receiving immunosuppressive treatments

          -  Received local steroid injection within 3 months of randomization

          -  Unable to comply with follow-up.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          1. Symptomatic Hypertrophic Cardiomyopathy patients

          2. Abnormal Peak VO2

          3. No significant LVOT obstruction at rest (gradient < 30mmHg)

          4. Sinus rhythm

        Exclusion Criteria:

          1. Abnormal LFT.

          2. Concomitant use of amiodarone

          3. Pre-existing evidence of peripheral neuropathy.

          4. Women of childbearing potential.

          5. Patients with ICD's will be excluded from the MR part of the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children

Eligibility criteria:
-  Short stature and/or constitutional growth delay

          -  No epilepsy or risk of epilepsy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain

Eligibility criteria:
Inclusion Criteria:

          -  Participants diagnosed with osteoarthritis and chronic low back pain

          -  3 months of persistent moderate to severe pain levels

          -  More than 3 times a week frequency or daily moderate to severe pain

          -  Moderate to severe pain at Baseline (at least a score of 4 in the 11-point numerical
             pain scale) Exclusion Criteria

          -  History of allergy to fentanyl transdermal patch or its components and history of
             illicit drug use for the past 3 months

          -  Active skin disease preventing application of the transdermal system

          -  Chronic pulmonary disease (lung disorder)

          -  Participants susceptible to intracranial (inside the skull) effects of carbon dioxide
             retention

          -  Pregnant and breastfeeding mothers
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction