Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Prevalence Rate of Pulmonary Embolism Among Not Anticoagulated Patients

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female over 75 years-old

          -  Emergency consult resulting on an hospitalization in the geriatric service or in the
             internal medicine service

          -  Hospitalised in the Centre Hospitalier Intercommunal de Toulon for syncope, presenting
             these symptoms:

          -  Loss of consciousness with quick return to normal (less than one minute)

          -  Spontaneous resolution

        Exclusion Criteria:

          -  history of syncope

          -  other loss of consciousness (epilepsy, stroke, head trauma)

          -  anticoagulated treatment

          -  patient's objection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 75 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Registry of Coronavirus Complications - CORRELATION WITH GLYCOMIC PROFILE

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of COVID19 virus infection (buffer/BAL/positive IgG serology)

          -  Age >18 years

          -  Able to express informed consent to participate in the study

        Exclusion Criteria:

          -  patients unable to express consent,

          -  patients aged <18 yr,

          -  with signs and symptoms compatible with Covid-19 but without certified diagnosis by
             swab/BAL or serological examination of presence of COVID IgG antibodies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: A Study of the Pharmacokinetics of Ustekinumab in Chinese Male Subjects

Eligibility criteria:
Inclusion Criteria:

          -  Have no clinically relevant abnormalities

          -  Non smoker

        Exclusion Criteria:

          -  Have or had a history of clinically significant, severe, progressive, or uncontrolled
             renal, hepatic, hematological, gastrointestinal, endocrine, pulmonary, cardiac,
             neurologic, cerebral, or psychiatric disease

          -  Have any underlying physical or psychological medical condition

          -  Be unable or unwilling to undergo multiple venipunctures because of poor tolerability
             or lack of easy access to veins
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn

Eligibility criteria:
Inclusion Criteria:

          1. Experiencing heartburn at least 2 days per week over the past month.

          2. Having heartburn that responds to heartburn medication.

          3. Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
             in the study.

        Exclusion Criteria:

          1. Having history of erosive esophagitis or gastroesophageal reflux disease diagnosed by
             a physician and confirmed by testing (endoscopy).

          2. Be unwilling to take only the study medication, and antacid provided as a rescue
             medication for relief of acute heartburn during the study.

        Other protocol-defined inclusion or exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Resuscitation Plans and Decisions on Escalation and Limitation of Treatment

Eligibility criteria:
Inclusion Criteria:

          -  adults with COVID19 (proven by polymerase chain reaction, or with strong clinical
             suspicion based on clinical features and/or radiodiagnostics)

        Exclusion Criteria:

          -  minors
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Reactivating Specific Memories During Sleep in Conjunction With a Suppression Context

Eligibility criteria:
Inclusion Criteria:

        ---

        Exclusion Criteria:

        Participants with a history of neurological disorders or of sleep disorders will be
        excluded.

        Participants who do not believe they would be able to fall asleep in the lab will be
        excluded.

        Participants with severe asthma requiring hospitalization for treatment, history of
        significant food or non-food allergy, presence of known smell, taste or ear-nose-throat
        disorder, or a history of sinusitis or allergic rhinitis will be excluded.

        Participants who are certain they breathe through their mouths during sleep and those who
        snore (and therefore likely breathe through their mouths as well) will be excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Point Of Care UltraSonography for Risk-stratification of COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patient with COVID-19 confirmed by positive RT-PCR or considered as probable by the
             in-charge physician,

          -  ≥18 years old,

          -  Not requiring respiratory assistance and/or other intensive care

          -  Not subject to a limitation of active therapeutics

        Exclusion Criteria:

          -  History of pneumonectomy

          -  Any reason making chest ultrasonography impossible

          -  Any reason making 14-day follow-up impossible

          -  Patient opposition to research participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Optimising Steroid Replacement in Patients With Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  Male or female patients ≥ 18years of age with Primary Adrenal Insufficiency (Addison's
             disease) confirmed on biochemical testing.

          -  Male or female patients ≥ 18years of age with ACTH deficiency defined by a stimulated
             peak cortisol in response to insulin-induced hypoglycaemia or short synacthen testing
             <400 nmol/l, with known organic pituitary disease, and no adjustment in hormone
             replacement for at least 3 months prior to study entry.

          -  Signed informed consent to participate in the study

        Exclusion Criteria:

          -  Age < 18 years

          -  Patients with acute medical or surgical illness

          -  Patients with advanced cardiac/pulmonary disease

          -  Patients with a terminal illness

          -  Patients on glucocorticoids for purposes other than ACTH deficiency

          -  Patients on agents that interfere with corticosteroid metabolism
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT

Eligibility criteria:
Inclusion criteria

          -  age<40 years,

          -  first ICSI cycle,

          -  third day FSH< 10 mIU/mL,

          -  serum E2 level on day of hCG administration <4,000 pg/mL,

          -  number of ova obtained >15

        Exclusion Criteria:

          -  age 40 years or more,

          -  basal FSH 10 mIU/mL or more ,

          -  eggs retrieved 15 or less ,

          -  E2 level on day of hCG administration 4000 or more pg/ mL or more,

          -  repeat ICSI , need for PGD, presence of myoma , hydrosalpinx (unless disconnected)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Investigating a Von Willebrand Factor (VWF) Functional Screening Assay for Assigning the Phenotypic Variants of Von Willebrand Disease (VWD)

Eligibility criteria:
Inclusion Criteria:

          -  New subjects undergoing evaluation for the diagnosis of VWD determined to have a
             VWF:Ag or VWF: RCo < 50 IU/dl and or a VWF:RCo/VWF:Ag of <0.7. Also subjects will be
             included if Type 2 N VWD is clinically suspected

        Exclusion Criteria:

          -  Those subjects whose lab results do not meet the inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Mirena or Conventional Medical Treatment for Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
             next year

          -  Women complaining of heavy menstrual bleeding over several consecutive cycles

          -  Women without structural or histological abnormality of the uterus, or with fibroids
             less than 3 cm in diameter which are causing no distortion of the uterine cavity
             (eligible for pharmaceutical treatment according to the NICE guideline 2007)

          -  Informed consent (where required by laws or regulations)

        Exclusion Criteria:

          -  The contraindications and warnings of the respective Summary of Product
             Characteristics (Mirena, combined oral contraceptives, oral/injectable progestogens,
             non-steroidal anti-inflammatory drug, or anti-fibrinolytic agent) must be followed.

          -  Women taking hormone replacement therapy

          -  Women with symptoms such as intermenstrual or post-coital bleeding, unless an
             endometrial biopsy has been performed and pathology excluded

          -  Women with fibroids that are palpable abdominally or who have intra-cavity fibroids
             and/or whose uterine length as measured at ultrasound or hysteroscopy is greater than
             12 cm (NICE guideline 2007)

          -  Women on anticoagulative therapy or other treatment (including e.g. Copper IUD use)
             known to cause menorrhagia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment