Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: MCE Direct Visualization of Drug Behavior in Upper-gastrointestinal Tract

Eligibility criteria:
Inclusion Criteria:

          -  With or without gastrointestinal complaints

          -  Scheduled to undergo a capsule endoscopy for both stomach and small bowel

          -  Signed the informed consents before joining this study

        Exclusion Criteria:

          -  Suspected or known gastrointestinal stenosis

          -  Obstruction or other known risk factors for capsule retention

          -  Pregnancy or suspected pregnancy

          -  Pacemakers or electromedical devices implanted

          -  Any other contraindications determined by endoscopists
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Effects of Testosterone on Prostate Tissue (ACYP-1)

Eligibility criteria:
Inclusion Criteria:

          -  Males between 35 and 55, normal serum testosterone levels, normal gonadal function

        Exclusion Criteria:

          -  History of prostate cancer, PSA>2.0, AUA BPH symptom score >10, History of
             testosterone or anabolic steroid use, chronic medical illness or prostate disease,
             active serious infection or immunosuppression, history of a bleeding disorder or need
             for anticoagulation, abnormal digital rectal exam, abnormal prostate ultrasound, first
             degree relative with history of prostate cancer
Male
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Sublingual Versus Vaginal Misoprostol In Medical Treatment of First Trimestric Missed Miscarriage

Eligibility criteria:
Inclusion Criteria:

          -  All women above 18 years of age

          -  Less than 12 weeks of gestation.

          -  Pregnancy is confirmed by pregnancy test or ultrasound scan.

          -  missed abortion

          -  Normal general and gynecological examination.

          -  The size of the uterus on pelvic examination was compatible with the estimated
             duration of pregnancy

        Exclusion Criteria:

          -  Hemodynamically unstable.

          -  Suspected sepsis with temperature 38 °C.

          -  Concurrent medical illness e.g. hematological, cardiovascular, thromboembolism,
             respiratory illnesses, recent liver disease or pruritus of pregnancy.

          -  Presence of intrauterine contraceptive device (IUCD).

          -  Suspect or proven ectopic pregnancy.

          -  Failed medical or surgical evacuation before presentation.

          -  Known allergy to misoprostol.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Individualized Comprehensive Rehabilitation Program in Chronic Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of primary symptomatic KOA according to the criteria of the American College
             of Rheumatology

          -  Women aged older than 65 years

          -  Pain predominantly over the last 3 months

          -  Kellgren and Lawrence score ≥2.

        Exclusion Criteria:

          -  Ankle, hip or foot severe disorders

          -  Chronic back pain

          -  Alzheimer's disease, Parkinson's disease, motor neuron disorders.

          -  Diabetes mellitus

          -  Cardiac or respiratory insufficiency

          -  Inability to understand the procedure
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Efficacy and Safety of a a Biofunctional Textile in the Management of Atopic Dermatitis

Eligibility criteria:
Inclusion Criteria:

          -  clinical diagnosis of Atopic Dermatitis

          -  older than 12 years old

        Exclusion Criteria:

          -  other specific forms of eczema such as contact eczema, seborrheic eczema, nummular
             eczema, occupational dermatitis, hand eczema

          -  systemic diseases that can be accompanied by immunological skin abnormalities as
             psoriasis;

          -  clinically significant chronic infectious disease(s) (eg, HIV, hepatitis B or C);

          -  breastfeeding,pregnant/intending to become pregnant during study;

          -  participation in any other clinical study;

          -  part of the staff personnel involved with the study;

          -  family member of investigational/study staff.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Test to Determine the Effectiveness of Moisturizing Balm Used on Babies With Dry, Itchy Skin

Eligibility criteria:
Inclusion Criteria:

          1. Able to comprehend and follow the requirements of the study (including availability on
             scheduled visit dates)

          2. Male or female of any race or ethnicity, 6 months to 47 months of age;

          3. Diagnosed as having eczema

          4. Willing to stop use of all non-assigned moisturizers and/or creams for the entire
             duration of the study

          5. Child must have bedtime/sleep issues due to their dry, itchy skin

        Exclusion Criteria:

          1. Use of a therapeutic (over-the-counter or prescription) body wash that contains an
             active ingredient for eczema

          2. Participation in any clinical study within 30 days of Visit 1

          3. Active infection of any type at the start of the study

          4. Diagnosed as having severe eczema

          5. Atopic Dermatitis requiring systemic, super-potent (Class I) or potent (Class II or
             III) topical corticosteroids

          6. Child wakes up 3 or more times during the night

          7. Child is awake more than 60 minutes during the night

          8. Child sleeps for less than a total of 9 hours (during the day or night)

          9. Child requires greater than 2.0 mg per day of inhaled or intranasal corticosteroids
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 47 Months

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Three-dimensional Kinematic Motion Analysis of Finger and Wrist During Daily Activities

Eligibility criteria:
Inclusion Criteria:

          -  Volunteers of 20 healthy, right dominant hands

          -  10 patients with tendon pathologies

          -  10 patients with Dupuytren disease

          -  10 patients with osteoarthritis of the wrist

          -  Patients older than 18 years

          -  Patient willing and able to give written informed consent to participate in the study

        Exclusion Criteria:

          -  Inflammatory disease (e.g. rheumatoid arthritis)

          -  Pregnant women

          -  German language barrier to complete the questionnaires

          -  Any disease process that would preclude accurate evaluation (e.g. neuromuscular,
             psychiatric or metabolic disorder)

          -  Legal incompetence

          -  Participation in any other medical device or medicinal product study within the
             previous months that could influence the results of the present study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft

Eligibility criteria:
Inclusion Criteria:

          -  Patient currently a patient at dental school or eligible for treatment at dental
             school

          -  Patient resides within 50 mile radius of dental school

          -  A single rooted tooth that has been identified by dental faculty as requiring
             extraction

          -  Have adequate restorative space for a dental implant-retained restoration

          -  Have at least 10mm of alveolar bone height, without impinging on the maxillary sinus
             or inferior alveolar canal.

          -  Have a dehiscence of the buccal or lingual bony plate of the tooth socket extending no
             more than 50% of the total depth of the socket.

          -  Female patients who have undergone a hysterectomy, tubal ligation, or menopause, and
             non-pregnant women of child-bearing potential.

        Exclusion Criteria:

          -  not meeting inclusion criteria above

          -  Active localized or systemic infection other than periodontitis.

          -  Inadequate bone dimensions or restorative space dimensions to place a dental implant

          -  Presence of a disease entity, medical condition or therapeutic regimen which decreases
             probability of soft tissue and bony healing, e.g., poorly controlled diabetes,
             chemotherapeutic and immunosuppressive agents, autoimmune diseases, history of
             bisphosphonate use or long-term steroid therapy.

          -  Positive medical history of endocarditis following oral or dental surgery.

          -  Sensitivity or allergy to Bacitracin, Gentamicin, Polymyxin B Sulfate, alcohol and/or
             surfactants (per package insert)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Liquid Meal Replacements in Conjunction With Lifestyle Intervention in Overweight Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  BMI >85th% for age and sex

          -  Weight gain over the last 6 months of >5% than expected on the growth curve

          -  12-17 years of age

        Exclusion Criteria:

          -  Subjects with intolerance to dairy products (e.g., lactose intolerance) will be
             excluded from entering into the study.

          -  Subjects must not have a history of clinically significant cardiac disease, congenital
             heart disease, any clinically significant abnormal cardiac condition, or be known to
             have a clinically significantly abnormal ECG. Specifically excluded conditions include
             coronary artery disease, clinically significant cardiac arrhythmias, and congestive
             heart failure.

          -  Subjects must not have a history of anorexia nervosa, untreated hypothyroidism (TSH
             greater than 4.0 mU/L for a second generation test), malignancy, pathophysiologic or
             genetic syndromes associated with obesity (i.e., Cushing's syndrome, Turner's
             syndrome, Prader Willi syndrome), major psychiatric illness such as bi-polar disorder,
             ADD, major depression, bulimia, schizophrenia, or psychosis.

          -  Subjects may not participate in any weight management program, except for that in this
             study, during this pilot. Subjects may not use prescription or over-the-counter (or
             herbal) weight control medication during the trial.

          -  Subjects must not have a history of alcohol or drug addiction or substance abuse
             within the previous 2 years.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Italian Validation of the Beaumont Behavioural Inventory (BBI)

Eligibility criteria:
Inclusion Criteria:

          -  possible, probable or definite ALS according to El Escorial revised criteria

        Exclusion Criteria:

          -  Any other clinically significant cardiovascular, gastrointestinal, hepatic, renal,
             neurological or psychiatric disorder or any other major concurrent illness that in the
             opinion of the investigator could interfere with the interpretation of the study
             results
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment