Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: A Study to Evaluate the Efficacy of Teprenone On Chinese Patients With Chronic Non-Atrophic Erosive Gastritis

Eligibility criteria:
Inclusion Criteria:

          1. 18-65 years old

          2. Have been diagnosed as chronic non-atrophic erosive gastritis by endoscopy within 1
             weeks before enrollment, and the modified Lanza score ≥ 2

          3. Have at least two symptoms in four major symptoms (epigastric pain, epigastric
             burning, early satiety, belching) and total symptom score ≥ 4 (Rome Ⅲ for Functional
             Gastrointestinal Disorders)

        Exclusion Criteria:

          1. Suspected upper gastrointestinal malignancy by endoscopy

          2. Peptic ulcer and bleeding by endoscopy

          3. Severe cardiac, hepatic or renal insufficiency

          4. Severe neurological or psychological disease

          5. Pregnant or lactating women

          6. Have taken drugs which may affect evaluating the efficacy of study drug within two
             weeks before enrollment (includes but not limits to: Proton pump inhibitors such as
             omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, H2 receptor
             antagonists such as cimetidine, ranitidine, famotidine, antacids such as calcium
             carbonate, gastric mucosal protectants such as colloidal bismuth potassium citrate and
             other bismuth products, sucralfate, aluminum phosphate, teprenone, gefarnate, aluminum
             magnesium carbonate, glutamine, rebamipide, ecabet, misoprostol, antibiotics such as
             amoxicillin, clarithromycin, tetracycline, ofloxacin, levofloxacin, furazolidone,
             metronidazole, tinidazole, Non-Steroid Anti-Inflammatory Drugs such as aspirin,
             ibuprofen, loxoprofen, naproxen, diclofenac, indomethacin, meloxicam, acetaminophen)

          7. History of allergic reaction to the medications used in this study

          8. Patients that investigators consider ineligible for this study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction