Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia

Eligibility criteria:
Inclusion Criteria:

        - AD diagnosis or AD with CVD according the criteria of National Institute on Aging and the
        Alzheimer's Association workgroup and the National Institute of Neurological and
        Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders
        Association (NINCDS-ADRDA)

        Exclusion Criteria:

          -  Patients with mild cognitive impairment;

          -  Other types of dementia, such as pure vascular dementia, frontotemporal dementia,
             dementia with Lewy bodies, corticobasal degeneration;

          -  Severe dementia (CDR 3)

          -  Those who were already taking ChEI,

          -  If there have not been agreement between the first researcher and the treating
             physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 59 Years old.
Subject must be at most 92 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  primary or scondary Sjogren's syndrome

        Exclusion Criteria:

          -  allergy to milk derivatives previous intake of antifungals
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Study of N-acetylcysteine in Patients With COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          -  Documented COVID-19 infection (either performed on site or documented external report)

          -  Age ≥ 18

        Arm A:

          -  Admission to an intensive care unit at MSK (M-11) and/or receiving mechanical
             ventilation

          -  Absolute lymphocyte count ≤ 1.0/mm3

          -  As the ALC of patients with lymphoid malignancies is unreliable, they may be enrolled
             at the discretion of the treating physician after review of their blood work.

        Arm B:

          -  Arm B:Requiring 2L or more of supplemental oxygen by nasal cannula or higher to
             maintain SpO2 of 95%

        Exclusion Criteria:

        Arm B:

          -  requiring mechanical ventilation or admission to an intensive care unit at MSK (M11)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1

Eligibility criteria:
Inclusion Criteria:

          -  DSM-IV diagnosis of nicotine dependence with psychological dependence

          -  Smokes at least 15 cigarettes per day for the three months prior to enrollment

          -  Currently not seeking treatment for nicotine dependence

          -  Medically healthy on the basis of physical examination and medical history, vital
             signs, EKG, and laboratory tests

          -  Females must use an effective method of contraception for the duration of the study

        Exclusion Criteria:

          -  DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine

          -  Current Axis I diagnosis or current treatment with psychotropic medications within the
             three months prior to enrollment

          -  History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety
             disorders

          -  Currently seeking treatment for nicotine disorders

          -  On parole or probation

          -  History of seizures or head trauma with loss of consciousness, brain contusion, or
             fracture

          -  History of significant recent violent behavior

          -  Blood pressure greater than 150/90

          -  History of eating disorders

          -  History of allergic reaction to any of the study medications

          -  Pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  ALS

          -  FVC >=50%

          -  Abnormality in upper and/or lower extremity motor function

          -  Not pregnant

          -  Disease duration <5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Quality of Life and Physical Performance After Novel Coronavirus Infection (COVID-19);

Eligibility criteria:
Inclusion Criteria:

          -  Hospitalized at the Kantonsspital Winterthur (KSW) due to COVID-19 infection
             (laboratory-confirmed),

               -  with or without mechanically assisted ventilation

               -  being at risk to obtain severe illness caused by the COVID-19*

               -  individuals without defined risk factors but requiring oxygenation during
                  hospitalisation

          -  Agree to general consent or specific consent to subsequent use of his/her personal
             health data for research purpose

          -  German-speaking

        Exclusion Criteria:

          -  Presence of mental disability or impairments to reasoning or judgment

          -  Individuals who are immunocompromised due to medical treatment

          -  A documented objection of subsequent use of personal health data

        Specific exclusion criteria for presence at the hospital (for evaluation and training);
        criteria will be verified during the phone-based screening process. After two weeks of a
        COVID-19 positive diagnosis and with four entire days the patient reports no signs of:

          -  fever >37.3° C

          -  sore throat,

          -  cough (productive or non-productive)

          -  common cold

        Also, treatment-based immunocompromised patients are excluded for on-site evaluation and
        training.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Home-Based Covid-19 Rehabilitation Program

Eligibility criteria:
Inclusion Criteria:

          1. Age 18 and older.

          2. Symptoms suggestive of Covid-19 infection (fever, cough, chest discomfort or loss of
             smell/taste).

          3. Covid-19 screening done.

          4. Ambulatory without assistive devices (such as cane or walker).

          5. Access to PT-Pal app via cellular phone, iPad or computer (e.g. Zoom™).

        Exclusion Criteria:

          1. Severe symptoms requiring referral to the Emergency Department.

          2. Contraindications to exercise (cardiac disease such as diagnosed arrhythmias, on home
             oxygen, or end stage organ failure).

          3. Known history of poorly controlled diabetes or hypertension.

          4. Active neurological or psychiatric illnesses.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage

Eligibility criteria:
Inclusion Criteria:

          -  pregnant women between 20-40 years. Pregnancy between 6-10 weeks. single intrauterine
             spontaneous pregnancy. vaginal bleeding or bloody vaginal discharge with or without
             pelvic pain for patients with threatened miscarriage.

        Exclusion Criteria:

          -  medical disorders with pregnancy. History of recurrent miscarriage. Any maternal
             disease that would cause an increase in CA125 level. Local gynecological disorders
             e.g. fibroid. Presence of any uterine malformation. History of congenital
             abnormalities in previous pregnancy Presence of multiple pregnancy. Presence of
             anembryonic sac. Absent fetal heart pulsation.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Efficacy and Safety of QL1206 in the Treatment of Postmenopausal Osteoporosis With High Fracture Risk

Eligibility criteria:
Inclusion Criteria:

          1. Subject is willing to provide written informed consent.

          2. Ambulatory woman between the age of 50 and 85 years, inclusive.

          3. The subject has a BMD absolute value consistent with a T-score<-2.5 and >-4.0 at
             either the lumbar spine or total hip

          4. All subjects must have at least one of following additional the risk factors:history
             of fracture（after 40 years）,parental history of hip fracture, low Body mass index
             (BMI≤19kg/m^2), elderly (age≥65year)，current smoker

          5. Postmenopausal defined as >2 years postmenopausal, which can be >2 years of
             spontaneous amenorrhea or >2 years post surgical bilateral oophorectomy.

        Exclusion Criteria:

          1. Bone/metabolic disease:a. Any metabolic bone disease, e.g., osteomalacia or
             osteogenesis imperfecta,which may interfere with the interpretation of the findings.

             b. Paget's disease c. Cushing's disease d. Hyperprolactinemia

          2. Current hyperparathyroidism or hypoparathyroidism by medical record

          3. Thyroid condition: Hyperthyroidism or hypothyroidism.

          4. Rheumatoid arthritis

             -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Imaging in the Diagnosis of Parkinson's Disease and Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Parkinson´s disease patients according to UK Parkinson´s Disease Brain Bank Criteria

          -  Essential Tremor Patients according to Movement Disorder´s diagnosis consensus
             criteria.

          -  Healthy Volunteers: paired with PD patients by age and gender.

        Exclusion Criteria:

          -  Contraindication to MRI

          -  Claustrophobia.

          -  Serious structural brain anomalies.

          -  Condition or situation in which, in the opinion of the investigator put the patient at
             significant risk, which can confound the results, or substantially interfere with the
             individual's participation in the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment