Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Measurement and Evaluation of Total Lung Capacity (TLC) in the Field of Pulmonary Functional Testing (PFT)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is at least 18 years of age.

          2. Subject is cooperative and capable of following instructions.

          3. Healthy subjects:

               1. Never smokers.

               2. No known history of respiratory, cardiovascular, hepatic, renal or metabolic
                  disease.

               3. BMI < 35.

               4. No persisting respiratory symptoms during the last 12 months. (e.g., dyspnea,
                  chronic cough, wheezing or phlegm).

               5. No history suggesting upper respiratory infection during the three weeks prior to
                  testing.

          4. Patients with known disease affecting the respiratory system, with previous
             documentation of obstructive, restrictive, or mixed obstructive plus restrictive
             ventilatory abnormality.

        Exclusion Criteria:

          1. Subjects who are unable to satisfactorily perform routine, full lung function
             testing(due to non-compliance or claustrophobia).

          2. Subjects unable or unwilling to give informed consent.

          3. Subjects who have performed any significant physical activity during 1 hour prior to
             the Study.

          4. Patients with a tracheostomy.

          5. Pregnant women.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction