Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Cases of knee joint degeneration diagnosed by orthopedics, rheumatology and immunology
             physicians.

          -  X-ray interpretation (kellgren & Lawrence grade) grades 1 to 3 or mild to moderate
             patients.

          -  Willing to sign written consent form.

          -  Pain Index (VAS) ≧ 4/10.

          -  Men and women over the age of 55.

          -  Body mass index (BMI) ≧ 27 kg/m^2.

        Exclusion Criteria:

          -  Unable to act on your own.

          -  X-ray interpretation (kellgren & Lawrence level) is greater than level 3 or is a
             serious level.

          -  Patients who have undergone knee arthroplasty on one or both feet.

          -  Patients with terminal liver and kidney disease.

          -  Those who are unable to perform physical function measurement after severe diagnosis
             of heart and lung disease after diagnosis by the physician.

          -  High blood pressure with poor control (systolic blood pressure greater than or equal
             to 180 mmHg at the time of return).

          -  Pregnant women or breastfeeding women.

          -  Those who have coronary stents, cardiac rhythms, or other metallic substances in the
             body are not recommended for total body composition analysis.

          -  Those with severe hip, knee, and lower back pain who are unable to perform exercise,
             other neuromuscular, skeletal joints, or rheumatic diseases may be exacerbated by
             exercise. Or those who have musculoskeletal injuries in the past six months (such as
             bruises, fractures, etc.).

          -  Unable to cooperate with the test or halfway through the test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment