Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: A Prospective Observational Study of the Clinical Performance of Zarin in Madagascar

Eligibility criteria:
Inclusion Criteria:

          -  be a participant of the MSM service evaluation and continue using Zarin at 3 months

          -  agree at the time of Zarin insertion to be contacted regarding an opportunity to
             participate in more research related to the implant

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Treatment With a Spinal Orthosis Compared to Equipment Group Training and a Control Group

Eligibility criteria:
Inclusion Criteria

          -  Woman aged ≥ 60 years

          -  Osteoporosis according to DXA (Dual X-Ray Absorptiometry) hip (femoral neck or total
             hip) or lumbar spine.

          -  Back pain.

        Exclusion Criteria

          -  Diagnosed symptomatic spinal stenosis

          -  Difficulty to participate in the activities included in the study due to health
             problems.

          -  Difficulty to participate in equipment training group.

          -  Inability to be able to complete wearing the spinal orthosis.

          -  Language difficulties

          -  Cognitive difficulties

          -  Visual problems
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Long-term Effect of Electromagnetic Field in Treatment of Patients With Osteopenia or Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a T-scores of ≤ ˗1.5, all patients received the same medical treatment
             for osteoporosis and the same average blood glucose level, sufficient ability to
             understand the nature and potential risks of the study.

        Exclusion Criteria:

          -  Diabetes mellitus, ischemic heart disease, arrhythmia, uncontrolled thyroid disease,
             cardiac pacemaker, tuberculosis, neuropsychiatric disorders (dementia, cerebrovascular
             disease, alcohol abuse, severe depression, panic disorder, bipolar disorder, or
             psychosis), and malignancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: True Short Esophagus in Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients submitted to primary minimally invasive surgery for gastroesophageal reflux
             diseases or hiatus hernia.

          -  Age > 18 years.

        Exclusion Criteria:

          -  Patients already submitted to minimally invasive surgery for gastroesophageal reflux
             diseases or hiatus hernia for recurrence of the disease.

          -  Patients submitted to open surgery for gastroesophageal reflux diseases or hiatus
             hernia.

          -  Patients affected by other esophageal diseases.

          -  Age < 18 years.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with a definite diagnosis of sarcoidosis according to international ATS and
             WASOG guideline

        Exclusion Criteria:

          -  Ongoing CPAP treatment

          -  Psychiatric disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Hormonal Regulation of Puberty and Fertility

Eligibility criteria:
-  INCLUSION CRITERIA:

        Since hypogonadotropic hypogonadism is a rare condition, with an incidence of 1/10,000 to
        1/86,000 for isolated GnRH deficiency (34, 35), this protocol remains open to enrollment so
        that we may study all subjects that are both qualified and interested in participating.

        Males or females who are greater than or equal to 14 years old with clinical findings of HH
        as outlined above will be included. In certain circumstances, a patient under the age of 14
        years may be considered for baseline evaluation if there is sufficient evidence suggestive
        of HH, such as any two of the following: anosmia, history of cryptorchidism or
        microphallus.

        EXCLUSION CRITERIA:

        -Because HH represents a spectrum, where associated clinical findings may provide
        phenotypic clues to the assessment of inheritability and underlying physiology, exclusion
        criteria are very limited:

          -  Patients who have additional pituitary deficiencies, effectively ruling out isolated
             GnRH deficiency, whether these deficiencies are congenital or acquired (e.g. secondary
             to malignancy, infection, or irradiation).

          -  Patients who are taking medications known to cause HH, such as corticosteroids or
             continuous opiate administration.

          -  Pregnancy or lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients

Eligibility criteria:
Inclusion Criteria:

          -  male or female

          -  age of 20-75 years

          -  patients with GERD who have to receive PPIs for four weeks

        Exclusion Criteria:

          -  Suffering from peptic ulcer, gallstones, cancer, and Barrett's esophagus

          -  previously underwent the esophagus, stomach or duodenum surgery

          -  Lactating women or pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Efficacy of Combined Contraceptive Vaginal Ring(NuvaRing)in Women With Idiopathic Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Women with heavy menstrual bleeding based on PBAC score over 185 (mean of two control
             cycles)and desire contraception

        Exclusion Criteria:

          -  Menorrhagia of endocrine or systemic origin

          -  other pathology e.g. patients with fibroids of any size, adenomyosis, endometriosis,
             pelvic inflammatory disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Biomarkers in Giant Cells Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Patient suffering from giant cells arteritis.

          -  Inclusion while discovery of symptoms, or during relapse.

        Exclusion Criteria:

          -  Healthy volunteer

          -  Treatment with corticosteroid since more than 8 days for a patient suffering from
             giant cells arteritis, exept for patients under corticosteroid for a polymyalgia
             rheumatica.

          -  Other diseases than giant cells arteritis that could introduce an inflammatory
             symptom, especially a tumoral process in progress or a chronic inflammatory disease
             (any other one than giant cells arteritis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  A history of heartburn or acid regurgitation for 3 months or longer or any history of
             erosive esophagitis.

          -  Nightime heartburn averaging at least 2 or 3 times per week and a history of sleep
             disturbances associated with GERD for 1 month or more.

          -  Nightime heartburn graded as moderate or severe on 3 of the last 7 days of the run-in
             period and sleep disturbances associated with GERD as documented in the run-in diary
             card on at least 3 of the last 7 days of the run-in period..

        Exclusion Criteria:

          -  Any condition other than GERD that is either the primary cause of, or a significant
             contributor to the patients sleep disturbance.

          -  Shift workers who work between 12am (midnight) and 6am.

          -  Sleep medication, antihistamine, benzodiazepine, or anti-anxiety medication use that
             has not been stable for at least 3 months or is not expected to remain stable during
             the patients participation in the study.

          -  Other diseases / conditions as listed in the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment