Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with inflammatory osteoarthritis

          -  In good general health

          -  Stable pattern of anti-inflammatory or pain relieving drug use for 3 months prior to
             study

          -  Ability and willingness to maintain consistent pattern of anti-inflammatory or pain
             relieving drug use during the course of the study, and to not seek any other treatment
             during the study

          -  Ability and willingness to consume juice or placebo drink for 21 consecutive days, and
             to participate in screening measures, including a blood draw, before and after the
             intervention period

        Exclusion Criteria:

          -  Pregnancy

          -  Serious medical conditions such as recent heart attack or stroke, cancer, diabetes
             (type 1 and type 2), or gastrointestinal ulcers

          -  Individuals who have not been on a stable dose of pain medications or pain modalities
             for at least 3 months, including muscle relaxants, tender point anesthetic injections,
             systemic or intrabursal or intraarticular steroids, or any investigational drug/device
             in the prior 90 days

          -  Individuals who have used nonpharmacologic pain therapies including acupuncture,
             ultrasound, or transcutaneous electrical nerve stimulation within the past 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  Women who signed informed consent.

          -  Women who understand the Spanish language.

          -  Women under 40 years

        Exclusion Criteria:

          -  Thrombopenia.

          -  Congenital or acquired uterine malformations that reduce embryo implantation or term
             gestation.

          -  Ovarian tumors.

          -  Benign uterine tumors require surgical treatment

          -  Local acute inflammatory diseases

          -  Patients with malignant tumors requiring chemotherapy.

          -  Patients with acute or chronic infectious or inflammatory diseases requiring active
             treatment with drugs that may interfere with implantation and gestation.

          -  Chronic treatment with NSAIDs (Nonsteroidal anti-inflammatory drugs)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events

Eligibility criteria:
Inclusion Criteria:

          -  All hospitalized patients with cough, fever, myalgia - with confirmed COVID-19
             infection • All patients with a positive SARS-CoV-2 PCR test

        Exclusion Criteria:

          -  Patient refusal

          -  Uncertain tests results

          -  Children
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects

Eligibility criteria:
Inclusion Criteria: - Ambulatory postmenopausal women. - BMD values (g/cm2, Hologic) must
        be lower than 0.714 at lumbar spine, 0.515 at femoral neck, 0.588 at total hip. - BMD
        values must not be lower than 0.535 at the lumbar spine, 0.406 at the femoral neck and
        0.478 at the total hip. Exclusion Criteria: - Oral bisphosphonate treatments, PTH or PTH
        derivatives use within the last 12 months and administration of any of anti-osteoporotic
        treatments within the last 3 months before initial administration of the investigational
        product. - History of hypocalcemia. - More than two moderate vertebral fractures or any
        severe vertebral fracture.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Body Mass Index and Audiology Function

Eligibility criteria:
Inclusion Criteria:

        It will include 50 subjects whose:

          -  Age ranges from 10 to 40 years old.

          -  Body Mass Index more than the 85th percentile.

          -  male and female will be included

        Exclusion Criteria:

          -  External or middle ear disease that causes conductive hearing loss such as otitis
             media, otomycosis, perforated drum, tumors, dislocation of the ossicles.

          -  High environmental noise exposure which causes acoustic trauma such as exploration,
             fire shots and noise in industries.

          -  ototoxic drug intake such as Aspirin, Aminoglycosides, Erythromycin, Vancomycin
             Streptomycin, Kanamycin, Neomycin, Gentamycin, Tobramycin, Lasix, Cisplatin, Nitrogen
             Mustard, and Vincristine, and Quinine.

          -  Major neurological or psychiatric diseases brain tumor, vestibular Schwannoma, stroke,
             acoustic neuroma, encephalitis, meningitis, and depression.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Resolution of Comorbidities & Safety and Efficacy of Greater Curvature Plication in Obese Patients

Eligibility criteria:
Inclusion Criteria:

          1. Subject is willing to give consent and comply with evaluation and treatment schedule

          2. 18 to 65 years of age

          3. Have a BMI > 30 with one or more significant co-morbid medical conditions which are
             generally expected to be improved, reversed, or resolved by weight loss. these
             conditions include but are not limited to:

               -  Hyperlipidemia

               -  Type 2 diabetes

               -  Mild Obstructive Sleep Apnea

               -  Hypertension

               -  Osteoarthritis of the hip or knee

          4. Agree to refrain from any type of weight-loss drug ( prescription or OTC) or elective
             procedure that would affect body weight for the duration of the trial

          5. HbA1C < 11 %

          6. For subjects who have Type 2 Diabetes, the anti-diabetic medication regimen is no more
             complex than oral metformin plus one oral sulfonylurea plus once daily insulin
             injection.

          7. Ability to self-pay for the procedure and follow up.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: Using Online Videos to Supplement Emergency Department Discharge Instructions

Eligibility criteria:
Inclusion Criteria:

          -  Age > 16, or < 16 and accompanied by a legal guardian

          -  Has one of 38 ED discharge diagnoses

          -  Fluent in English, or caregiver fluent

          -  Has access to a computer, with internet access, in the next 4 days

          -  Has access to a telephone

        Exclusion Criteria:

          -  Age < 16 when unaccompanied by a legal guardian

          -  Decreased level of consciousness at ED discharge (eg palliative patient)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparing Pregnancy Outcomes in Good Prognosis Patients Between Fresh and 'Freeze-All' Single Blastocyst Transfers

Eligibility criteria:
Inclusion Criteria:

          -  First IVF cycle

          -  Normal ovarian reserve parameters (antral follicle count > 12, follicle stimulating
             hormone (FSH) < 10 IU/L, AMH (if measured) > 15 pmol/L)

          -  Infertility cause due to tubal factor, male factor with ejaculated sperm or
             unexplained

          -  3 or more fresh transfer or cryopreservation-quality blastocysts on day 5
             post-oocyte-retrieval

          -  GnRH antagonist or long GnRH agonist cycles

        Exclusion Criteria:

          -  Evidence of (or evidence for significant risk of) ovarian hyperstimulation syndrome
             (OHSS) on post-oocyte-retrieval day 5 (in which the standard protocol is not to
             perform a fresh embryo transfer, but rather to freeze all blastocysts for future
             frozen embryo transfers).

          -  Use of a gonadotropin releasing hormone (GnRH) agonist trigger for ovulation and
             resulting intensive luteal phase support protocol.

          -  Women requiring automatic freeze-all approaches (such as for pre-implantation genetic
             testing or cryopreservation for fertility preservation).

          -  Female infertility causes that may adversely affect implantation, such as severe
             endometriosis, fibroids, mullerian abnormalities, or prior uterine procedures
             resulting in a potentially compromised endometrial cavity.

          -  In-vitro maturation of oocytes

          -  Oocyte donation cycles
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Patients with persistent pain (< 6 mo) after open groin hernia repair

          -  Patients with maximal pain area 3 cm or less from the superficial inguinal ring

          -  Patients living in the Capital Region of Denmark (Region Hovedstaden) or the Region of
             Zealand (Region Sjælland)

        Exclusion Criteria:

          -  Known allergy to bupivacaine or other local anesthetics of amide-type

          -  Declared incapable of making his/hers own affairs

          -  Does not comprehend Danish in the written or spoken language

          -  Cognitive impairment to a degree influencing the testing reliability

          -  Known recurrence of the inguinal hernia

          -  Other surgical procedures performed in the groin or on the external genitals

          -  Neuropathy affecting the groin region caused by other conditions, e.g. post-stroke,
             multiple sclerosis, herniated intervertebral disc

          -  Abuse of alcohol or drugs

          -  Unable to cooperate with the sensory examinations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction