Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Management of Acute Ankle Sprain With Sodium Hyaluronate

Eligibility criteria:
Inclusion Criteria:

          -  • 18 years and older

               -  first or second degree lateral ankle sprain within 48 h of administration of
                  study drug

               -  reported moderate (45 - 60 mm) to severe (>60 mm) ankle pain on full weight
                  bearing on the Patient's Assessment of Ankle Pain using a 100 mm VAS

               -  available for the duration of the study (90 days)

        Exclusion Criteria:

          -  • Bilateral ankle sprain

               -  Ipsilateral knee injury

               -  Third-degree sprain

               -  Previous ankle sprain within 6 months

               -  Patients who had recently used anti-inflammatory medications, muscle relaxants
                  psychotropic medications that could confound the results

               -  Patients with a history of severe GI, renal, or hepatic disease

               -  Patients with rheumatic diseases

               -  History of drug or alcohol abuse

               -  Pregnant or lactating, or a woman of childbearing potential not willing to use an
                  acceptable method of contraception during the study

               -  Having received investigational product within 30 days of the Day 1 visit
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri

Eligibility criteria:
Inclusion Criteria:

          -  Women patient aged 30-45 years

          -  Diagnosed adenomyosis by transvaginal ultrasound or MRI or 3D ultrasound

          -  Patient complains of heavy menstrual bleeding or dysmenorrhea or both

          -  Living in a nearby area to make follow-up reasonably possible

          -  Planning for birth spacing for at least 2 years.

        Exclusion Criteria:

          -  Pregnancy or seeking fertility

          -  Severe underlying comorbidities (hepatic, oncological)

          -  Pelvic inflammatory disease

          -  Other cervical or uterine pathologies

          -  Deep venous thromboembolism

          -  Hormonal therapy contraindications

          -  Endometriosis or fibroid
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  We will recruit 30 poor ovarian responders and thin endometrium patients

        Exclusion Criteria:

          -  women with underlying medical diseases, such as diabetes or hypertension
Female
Accepts Healthy Volunteers

Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: MR Guided tDCS in Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimer's Disease, mild and moderate stage

        Exclusion Criteria:

          -  Other neurological diseases or injuries

          -  Stroke

          -  Cancer

          -  Psychiatric disorders (moderate/ severe depression, psychosis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Short Stature Related Distress

Eligibility criteria:
Inclusion Criteria:

        1 Segment 1 :Boys at the age range of 8-13 years 2. Segment 2: Boys at the age range of
        12-17 years 3. Tanner stage 1 (segment 1 only) 4. more than 2 SD's (standard deviation)
        below the average height

        Exclusion Criteria:

          1. Mental retardation,

          2. Psychiatric illness,

          3. Lack of informed consent\assent.

          4. Health status that required chronic treatment with steroids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: the Observance of Emergency Exit Treatments During the Stay of Care at the Exit of Reims Emergencies

Eligibility criteria:
Inclusion Criteria:

          -  adults

          -  consultation during the early stages of care

          -  leaving after consultation

          -  agrees to participate in the study

        Exclusion Criteria:

          -  minor patients

          -  permanently off care

          -  hospitalized patients

          -  refusal to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Evaluation of Patients With Endocrine-Related Conditions

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Adult patients of all ages with endocrine-related conditions will be eligible for this
             protocol.

          -  Both male and female subjects of all ethnic backgrounds are eligible.

        EXCLUSION CRITERIA:

          -  Unstable patients and patients with severe organ failure that may affect/limit the
             endocrine work-up and exhaust Clinical Center and/or NICHD resources will be excluded
             if appropriate. Decisions will be made on a case by case basis by investigators.

          -  Subjects who are unable to provide informed consent will not be accrued; however, if
             patients have previously given consent, they will continue to be seen for ongoing
             clinical care. If they require medically-indicated procedures, we will follow NIH
             policy regarding obtaining consent from next of kin if they have not indicated a
             medical decision maker.

          -  Minor subjects will not be accrued; they will be referred to NICHD protocols or other
             NIDDK protocols for evaluation of eligibility.

          -  Prisoners will not be recruited. If a subject becomes incarcerated during the study,
             s/he may continue to participate so as to not compromise medical care.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Electromagnetic Tracking to Measure Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Adults

          -  Individuals who have undergone or are scheduled to undergo Deep Brain Stimulation
             (DBS) placement

        Exclusion Criteria:

          -  Individuals who have not had or are not scheduled for Deep Brain Stimulation (DBS)
             placement
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Treatment of Tennis Elbow With Botulinum Toxin

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 18 years and up

          -  Pain at the lateral side of the elbow

          -  Pain at the lateral epicondyle during resisted dorsiflexion of the wrist with the
             elbow in full extension

          -  Pain for longer than 3 months

        Exclusion Criteria:

          -  Previous operations (including previous steroid injections for the disorder)

          -  Nerve entrapment

          -  Pregnancy and while breast-feeding

          -  Presence of systemic neuromuscular disorders such as myasthenia gravis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Hemodynamics Response to Upper Airway Obstruction in Marfan Syndrome

Eligibility criteria:
Inclusion Criteria:

        People with Marfan syndrome.

          -  Age ≥ 18yrs

          -  Able and willing to provide informed consent

          -  Willing to sleep connected to research apparatus

        Exclusion Criteria:

          -  Unstable cardiovascular disease (CHF, myocardial infarction or revascularization
             procedures, and unstable arrhythmias)

          -  Uncontrolled hypertension (BP > 190/110)

          -  Underlying obstructive or other intrinsic lung disease

          -  Renal failure on dialysis

          -  Cirrhosis

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: The Safety of Emicizumab SC Injection in Korean Patients With Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Patients with Hemophilia A (congenital factor VIII deficiency) who will receive
             Hemlibra SC inj. according to medical judgement of investigator (Severe for Hemophilia
             A patients without FVIII inhibitors).

          2. Signed informed consent form

        Exclusion Criteria:

          1. Subjects who are hypersensitive to Emicizumab

          2. Subjects who are hypersensitive to mouse or hamster protein

          3. Subjects with myocardial infarction or the history who are prohibited from
             administering L-Arginine containing drug

          4. Subjects who participated in other clinical trials within a month before enrollment
             (or the first administration of Hemlibra SC inj.) (Unable to participate in other
             clinical trials related to Hemophilia A treatment even after enrollment)

          5. Subjects who the investigator deems inappropriate for the study.
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment