Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Osteoarthritis, Kinesiophobia and Physical Activity

Eligibility criteria:
Inclusion Criteria:

        knee osteoarthritis aged 50 to 75 years knee pain lasting for than three months knee pain
        intensity over 20 mm on Visual Analog Scale-VAS

        Exclusion Criteria:

        knee operation, Malignant diseases Systemic infectious diseases inflammatory diseases
        Fibromyalgia syndrome physical therapy and/or a knee injection within the last three months
        antidepressants, pregabalin or duloxetine usage
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Methotrexate Treatment for Ectopic Pregnancy

Eligibility criteria:
Inclusion Criteria:

          -  tubal pregnancy

          -  tubal pregnancy except interstitial pregnancy

          -  a pretreatment β-hCG level <15000 mIU/mL

          -  a gestational sac with a largest diameter <4 cm

          -  hemodynamically stable status

          -  agreement to methotrexate treatment and follow up

        Exclusion Criteria:

          -  heterotrophic pregnancy

          -  a presence of embryonic cardiac motion

          -  clinically or sonographically suspected tubal rupture

          -  laboratory tests showing possible deleterious effects of methotrexate treatment on
             organ functions
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Effectiveness Gastric Balloon in Obese Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  Clinically obese or morbid obese males and females aged 14 - 19 years old (BMI > 3.5
             SD)

          -  Are able to attend biweekly to monthly sessions with our support team and are capable
             of adhering to the lifestyle changes advised

        Exclusion Criteria

          -  Previous esophageal or gastric surgery or history of intestinal obstruction;

          -  History of moderate to severe inflammatory disease of the gastrointestinal tract such
             as esophagitis, gastric or duodenal ulcers or congenital anomalies such as atresias or
             stenosis; gastric or esophageal varices; congenital or acquired intestinal
             telangiectasis

          -  Hiatus hernia >5 cm or <5cm with associated severe or intractable gastro-esophageal
             reflux symptoms (assessed at balloon insertion);

          -  History of significant psychological disorder (permission sought from lead care
             giver).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 19 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: The Efficacy and Safety of Traditional Chinese Medicine (TCM) to the Patient With Dizziness in Emergency Department

Eligibility criteria:
Inclusion Criteria:

          1. Patients with age between 20 to 80-year-old who can cooperate to the whole treatment,
             testing and questionnaire.

          2. The chief complaint is dizziness which diagnosed by the doctor in charge of the
             emergency department, in together to exclude the patients with severe unstable vital
             signs, and then consult for help with Chinese medicine.

          3. Sign the clinical trial agreement sheet.

        Exclusion Criteria:

          1. Inacceptable to the research content

          2. Unable to complete the study process

          3. Unwilling to cooperate with acupuncture and other treatments

          4. Abnormal blood clotting profile

          5. With wound or allergy over the treated acupoint

          6. Unstable vital sign

          7. Post major trauma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF

Eligibility criteria:
Inclusion Criteria:

          -  Patient's preparing for invitro fertilization and embryo transfer with endometrial
             growth of less than 7 mm, unresponsive to standard treatment

        Exclusion Criteria:

          -  Sickle Cell disease

          -  Renal insufficiency

          -  Upper respiratory infection or Pneumonia

          -  Chronic Neutropenia

          -  Known Past or present malignancy
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Emergency Department Safety Assessment and Follow-up Evaluation 2

Eligibility criteria:
Inclusion Criteria:

          -  ED patients >18 years old

          -  Seen in ED triage

        Exclusion Criteria:

          -  patients <18 years old

          -  not seen in ED triage

          -  Adults unable to consent

          -  Prisoners
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A Non-interventional Study to Identify the Patients With Severe Luteinizing Hormone Deficiency in the Daily Practice

Eligibility criteria:
Inclusion Criteria:

          -  Female subjects undergoing stimulation with Pergoveris for the ovarian stimulation
             with VZO or with IUI or in preparation for a technology of the assisted conception
             such as IVF or ICSI

        Exclusion Criteria:

          -  Subjects receiving combination cycles with clomifen, follitropin beta, urinary FSH,
             urinary human menopausal gonadotropin (hMG)
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Adrenal Scans With Radioiodine-Labeled Norcholesterol (NP-59)

Eligibility criteria:
Inclusion Criteria:

          -  Patient with clinical and laboratory suspicions of hypersecretion of adrenal cortical
             hormones

        Exclusion Criteria:

          -  n/a
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Hormone Replacement Therapy to Treat Turner Syndrome

Eligibility criteria:
INCLUSION CRITERIA:

        Girls and women with TS diagnosed by karyotype or other genetic evidence of X-chromosome
        defects and ovarian failure (diagnosed by failure to enter puberty spontaneously by age 18
        or 2nd degree amenorrhea greater than 6 months and FSH greater than 40 mIU/ml)

        Subjects with TS who have been previously exposed to estrogen and progestin effect, either
        endogenous or exogenous by medical treatment, sufficient to establish secondary sexual
        development and menses

        Subjects with TS - ages 14 to 50, who have completed near final height, as demonstrated by
        a bone age of greater than or equal to 14 years

        EXCLUSION CRITERIA:

        Chronological or bone age of less than 14 years

        Chronological age greater than 50 years

        Chromosomal disorders in addition to TS

        Absence of 2nd degree sexual development

        Growth hormone or androgen treatment within 6 months of starting study.

        Testosterone level greater than normal range for age.

        Contraindications to the use of estrogen, progestin or androgens: Neoplasia;
        Hypercoagulation disorder; Pregnancy; Gall bladder, biliary or liver parenchymal disease
        (evidenced by jaundice, gastrointestinal symptomatology, other clinical evidence of
        cholelithiasis or hepatitis); Hypertriglyceridemia (TGs greater than 300); Active coronary
        disease (evidenced by documented MI or coronary angiography.

        Mental or physical disability, which in the estimation of study investigators, prevents a
        candidate from participation in study.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: AMH and Dosing Regimens for Initial IVF Stimulation Protocols

Eligibility criteria:
Inclusion Criteria:

          -  first cycle of IVF with transfer of fresh embryo

        Exclusion Criteria:

          -  use of non-autologous oocytes; prior diagnosis of premature ovarian failure or
             diminished ovarian reserve; BMI>= 40; cryopreservation cycles; smokers; use of
             PGS/PGD; use of surgically retrieved sperm or patients with severe male factor; and
             oocyte- or embryo-banking cycles
Female
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Italian Translation of the Michigan Hand Outcomes Questionnaire

Eligibility criteria:
Inclusion Criteria:

          -  age > 18 years

          -  native Italian speakers

          -  wrist/hand pathology

          -  trauma (fractures, tendon injuries, etc.)

          -  chronic pathology, the pathology has been present for at least 1 month (tenosynovitis,
             chronic arthrosis pain, rheumatic hand or wrist disorders)

          -  in case of hand/wrist surgery: at least 4 weeks have elapsed since surgery to avoid
             that the patient could not perform certain actions evaluated by the scale, for example
             lifting a pan or shopping bags, due to normal post-operative precautions.

          -  full possession of mental capacity

        Exclusion Criteria:

          -  age < 18 years

          -  non-native Italian speakers of Italian, thus also excluding second generation Swiss
             Italians ("secundo")

          -  mental incapacity

          -  upper limb in cast/locked by splint (criterion in Chung's article 98) at the time of
             the evaluation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment