Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Home Blood Pressure Monitoring and Blood Pressure Control

Eligibility criteria:
Inclusion Criteria:

          -  adults age 18 years and older with essential hypertension.

          -  who are treated with medication to lower their blood pressure.

          -  whose mean daytime blood pressure at enrolment is 135/85 mm Hg or greater.

          -  and who are not currently using HBPM.

        Exclusion Criteria:

          -  a diagnosis of secondary hypertension.

          -  pregnancy.

          -  hypertension management primarily by a consultant.

          -  a disability that precludes use of a home blood pressure monitor.

          -  enrolled in another hypertension trial

          -  white coat hypertension
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Development of a Novel Human In Vitro Sarcoidosis Model

Eligibility criteria:
Inclusion Criteria:

          -  sarcoidosis, subjects (18 - 45 years of age), including 30 sarcoidosis, 15 latent TB
             and 15 healthy controls.

        Exclusion Criteria:

          -  pregnant women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Extension Study of NS-065/NCNP-01 in Boys With Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
Inclusion Criteria:

          1. Completed Study NS-065/NCNP-01-201 through Week 25.

          2. Willing and able to comply with scheduled visits, investigational product
             administration plan, and study procedures.

          3. Stable dose of glucocorticoid (GC), and is expected to remain on the stable dose for
             the duration of the study.

        Exclusion Criteria:

          1. Serious or severe adverse event in Study NS-065/NCNP-01-201 that precludes safe use of
             NS-065/NCNP-01.

          2. Patient had a treatment which was made for the purpose of dystrophin or its related
             protein induction after completion of Study NS-065/NCNP-01-201.

          3. Patient took any other investigational drugs after completion of Study
             NS-065/NCNP-01-201.

          4. Patient was judged by the investigator and/or the Sponsor that it was not appropriate
             to participate in the extension study for other reasons.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients

Eligibility criteria:
Inclusion Criteria:

          -  Adults or adolescents older than 12 years

          -  Patients under Prophylactic treatment with Advate® for at least 1 year

          -  Written informed consent.

        Exclusion Criteria:

          -  History of FVIII inhibitor (titre ≥ 0.6 BU [Bethesda unit]) or detectable FVIII
             inhibitors at screening (titre ≥ 0.4 BU),

          -  Another haemostatic defect

          -  Need for major surgery.

          -  Withdrawal of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis

Eligibility criteria:
Inclusion Criteria:

          -  Hirschsprungs disease confirmed preoperative and postoperative specimen pathology

        Exclusion Criteria:

          -  Other cases of Enterocolitis and constipation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux

Eligibility criteria:
Inclusion Criteria:

        Main inclusion criteria :

          -  Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or
             dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).

          -  Need of upper GI endoscopy and pH monitoring.

          -  Normal propagation of oesophageal persitaltic waves (manometry < 6 months).

          -  Age 18 -70 yrs

          -  Signed informed consent

          -  Normal coagulation

        Exclusion Criteria:

          -  Barrett's oesophagus

          -  Previous oesophageal bleeding

          -  Need of NSAID treatment.

          -  Previous sus mesocolic surgery

          -  Alcool consumption > 40g/d, smoking > 10 cig/j

          -  Pregnancy or lack of contraceptive disposal, breast feeding.

          -  Allergy to Xylocaïne
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma

Eligibility criteria:
Inclusion Criteria:

          -  Subject provides informed consent

          -  Subject is >18 years of age

          -  Subject is deemed competent for making medical decisions

          -  Subject is scheduled to undergo radiation followed by extrapleural pneumonectomy.

          -  Subject is a surgical candidate

          -  A negative pregnancy test is required in women of child-bearing potential, as standard
             of care.

        Exclusion Criteria:

          -  Subject is <18 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Triphasil.

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, nonpregnant women with regular menstrual cycles

          -  sexually active and at risk of pregnancy

          -  acceptable body mass index (BMI)

          -  last term pregnancy at least 42 days prior, nonlactating, with 1 normal menstrual
             cycle since

          -  sitting BP<140mmHg/<90mmHg

          -  1 normal menstrual cycle since removal of IUD or norplant

          -  agreement to use study drug for contraception for up to 13 cycles, except when backup
             contraception is required for disease protection or patch detachment

          -  agree not to use other systemic steroid medication

        Exclusion Criteria:

          -  Presence, history, hereditary predisposition or risk of deep vein thrombophlebitis or
             thromboembolic disorders

          -  cerebral vascular or coronary artery disease, hypertension, or severe migraines

          -  liver tumor resulting from estrogen-containing products

          -  diabetes mellitus

          -  cholestatic jaundice, liver or renal disease

          -  abnormal PAP smear

          -  undiagnosed abnormal vaginal bleeding

          -  thyroid disorder

          -  dermal hypersensitivity

          -  carcinoma of breast, genital tract or other estrogen-dependent neoplasia

          -  received any depot hormone injection within prior 6 months

          -  smoking women over 35 years of age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Immediate Effect Of Whole-Body Vibration And Walk in Osteoporosis/Osteopenia

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of osteoporosis or osteopenia examination of bone densitometry;

          -  Patients without severe neurological disease, vascular disorders, labyrinthitis and
             blindness;

          -  No use of gait auxiliaries;

          -  No history of fractures of the lower limbs in the last year;

          -  Do not be an alcoholic inactive (0 to 5 points) or less active (6 to 11 points)
             accordance with the usual physical activity questionnaire (QAFH).

        Exclusion Criteria:

        -Patients who submit to hypertensive peak, nausea and dizziness during the training
        program.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the
             presence of osteophytes or sclerosis at the Carpometacarpal joint

          -  Patient complaint of unacceptable pain despite modification of activity, a trial of
             splinting and a therapeutic dose of NSAIDS

          -  If bilateral disease, only the most severely involved hand, (as defined by VAS for
             pain), will be entered in the study.

          -  Proficiency in English.

        Exclusion Criteria:

          -  Previous bad injury to the thumb

          -  Previous hand surgery on the study thumb

          -  Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc)

          -  Rheumatoid arthritis or lupus

          -  Bleeding problems

          -  Being on blood thinners (except aspirin)

          -  Known allergies to any of the medications being used

          -  Allergies to chicken products

          -  Current use of oral steroids

          -  Cancer that is not cured or in remission

          -  Severe diabetes

          -  A serious infection somewhere else in the subject's body
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Contradiction