Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Visual Performance Measures in a Virtual Reality Environment for Assessing Clinical Trial Outcomes in Those With Severely Reduced Vision

Eligibility criteria:
Inclusion Criteria:

          1. Male and female participants

          2. Age 20-50

          3. Bilateral sight impairment due to Stargardt's disease, retinitis pigmentosa or
             albinism.

          4. Sight impairment criteria are as follows:

               -  Visual acuity of 3 / 60 to 6 / 60 with a full field of vision.

               -  Visual acuity of up to 6 / 24 with a moderate reduction of field of vision

        Exclusion Criteria:

          1. Any physical impairment that would make use of the virtual reality headset difficult
             or unsafe.

          2. A history of vertigo or dizziness.
No condition on gender to be admitted to the trial.

Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Understanding Adaptive Challenges Associated With Male-factor Infertility

Eligibility criteria:
Inclusion criteria:

        Men:

          -  in a partnered relationship with a female

          -  have been trying without success to conceive a pregnancy

          -  have been referred due to suspected or diagnosed male-factor infertility

          -  have the ability to read and write English

        Female Partner:

          -  18 to 40 years of age

          -  ability to read and write English

        Exclusion criteria:

          -  living children, either biological or adoptive

          -  history of vasectomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: A Post Marketing Surveillance Program for NutropinAq® in Paediatric Growth Disorders

Eligibility criteria:
Inclusion Criteria:

          -  Children of either sex who are treated with NutropinAq® for the treatment of growth
             failure

          -  Patients who are willing to comply with follow-up appointments throughout study
             participation

          -  Written informed consent signed by both parents or by the liable parent or by the
             legal guardian when applicable, and by the child when applicable

        Exclusion Criteria:

          -  Patients not treated with NutropinAq®

          -  Patients with closed epiphyses

          -  Patients with active neoplasia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function

Eligibility criteria:
Inclusion Criteria:

          -  documented circulating FVIII level of ≤1%

          -  age 3 - 20 years

          -  may be on primary or secondary prophylaxis

          -  granting of informed consent

        Exclusion Criteria:

          -  measurable inhibitor level at the time of enrollment

          -  ingestion of aspirin/supplement known to influence platelet function within 14 days of
             blood sampling, or ibuprofen within 3 days
Male
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer

Eligibility criteria:
-  INCLUSION CRITERIA

               1. Patients older than 16 years with well-differentiated papillary or follicular
                  thyroid cancer stage I or II, according to the NTCTCS classification at time of
                  surgery

               2. Patients younger than 45 years with any size of primary papillary or follicular
                  tumor

               3. Patients older than 45 years with:

                    1. primary papillary tumor less than 4 cm or

                    2. primary follicular tumor less than 1 cm

          -  EXCLUSION CRITERIA

               1. Patients with postsurgical thyroid remnant more than 5 g

               2. Patients with distant metastases

               3. Patients above 45 years of age having:

                    1. known cervical lymph nodes metastases

                    2. microscopic multifocal follicular cancer

                    3. microscopic extraglandular invasion of follicular cancer

                    4. gross extraglandular invasion of papillary or follicular cancer

               4. Patients with confirmed histological subtypes of well-differentiated thyroid
                  cancer such as Hurtle cell carcinoma, insular and tall cell variants of papillary
                  cancer.

               5. Pregnant or lactating women

               6. Patients with renal impairment defined as repeat serum creatinine concentrations
                  above 1.5 mg/dl on thyroid hormone

               7. Patients on chronic lithium therapy for psychiatric illness

               8. Patients with current unstable cardiovascular conditions

               9. Patients with severe chronic medical conditions (liver failure, severe
                  debilitation, dehydration, sodium depletion, any other cancer requiring therapy,
                  etc)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Frequency of Metabolic Syndrome in Down Syndrome Patients

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Down syndrome

        Exclusion Criteria:

          -  History of congenital cardiac defects requiring open-heart surgery

          -  History of gastroenterologic anomalies requiring bowel resection and/or ongoing
             medical intervention

          -  History of leukemia or other cancer

          -  History of hypothyroidism requiring thyroid hormone replacement
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 24 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Growth Response in Girls With Turner Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Turner syndrome

          -  If age below 3 years, either body height below - 1 SD (standard deviation) with
             average growth velocity according to chronological age or body height below 0 SD with
             growth velocity below -1 SD according to chronological age

          -  If age above 3 years, body height below - 1 SD with average growth velocity according
             to chronological age

          -  Measured parental height available

          -  Written informed consent
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Randomized Study of Daytime vs. Delayed Eating: Effect on Weight and Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  Adults of all races and ethnicities

          -  Age 21-45; BMI 20-27 kg/m2

          -  stable weight (+/- 10 lbs) over the previous 6 months

          -  Women must be pre-menopausal with regular menstrual cycles.

        Exclusion Criteria:

          -  Regular exercise more than 3 d/wk, for 30 min measured by exercise logs and actigraphy

          -  normal activity levels are required throughout the study (+/-30 min/wk of baseline
             level).

          -  Unstable, serious medical conditions

          -  use of medicine linked to weight gain/loss

          -  cancer, diabetes, or autoimmune disease

          -  use of illicit drugs, melatonin, diuretics or hypnotics

          -  current weight loss program; presence of a sleep disorder (determined by surveys and
             actigraphy)

          -  night shift work; extreme chronotypes (extreme larks or night owls)

          -  habitual waking outside of 0600 h-0930h

          -  habitual bedtime outside of 2200h to 2400h

          -  sleep duration outside of 6.5 to 8.5 h/night.

          -  Psychiatric exclusions will be depression (Patient Health Questionnaire-9 score 9),
             lifetime bipolar disorder, psychosis, or lifetime eating disorder; or any other severe
             psychiatric disorder judged to interfere with study adherence as assessed by the
             Structured Clinical Interview for the DSM-IV.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Dienogest for Treatment of Adenomyotic Uteri

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 20-40 years

          -  Women with ultrasonographic evidence of adenomyosis

          -  Woman complains of vaginal bleeding or pelvic pain related to adenomyosis

        Exclusion Criteria:

          -  Women with a history of malignancy or histological evidence of endometrial hyperplasia

          -  any adnexal abnormality on ultrasound

          -  undiagnosed vaginal

          -  contraindication to receive Vissane or gynera .
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Tragal Perichondrium Versus Pretragal Fascial (SMAS) Graft for Endoscopic Myringoplasty

Eligibility criteria:
Inclusion Criteria:

          1. Above 16 yrs old and less than 50 yrs old.

          2. Clinically diagnosed central tympanic membrane perforations or chronic suppurative
             otitis media (tubo-tympanic).

          3. Dry ear: no otorrhea without medication for at least 1 month.

          4. Hearing loss gap not more than 50dB

        Exclusion Criteria:

          1. Age less than 16 or more than 50.

          2. Discharging (active) central perforations.

          3. Unsafe CSOM with cholesteatoma.

          4. Suspected ossicular pathology in safe CSOM if the gap > 50dB.

          5. Previous ear surgery.

          6. Patients unfit for surgery or having chronic medical illness.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Intraperitoneal Chemotherapy and Systemic Chemotherapy Versus Systemic Chemotherapy After Curative Resection of Serosa-positive Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. histologically proven adenocarcinoma of the stomach

          2. preoperative suspicion of serosal invasion on the radiological examination

          3. candidate for curative resection of the stomach with D2

          4. age from 19 to 70 year old

          5. Eastern Cooperative Oncology Group Performance status :0, 1, or 2

          6. absolute neutrophil count≥1,500/microliter, hemoglobin≥9.0g/dL, and
             platelet≥100,000/microliter

          7. serum Creatinine<1.5mg/dL

          8. total bilirubin <2 x upper normal limit, transaminase<3 x upper normal limit

          9. patients without previous administration of chemotherapeutic agent

         10. patients who agreed and signed to the informed consent form

        Exclusion Criteria:

          1. malignancy of the stomach except for adenocarcinoma

          2. history of hypersensitivity to 5-fluorouracil or mitomycin

          3. concomitant infectious disease

          4. active hepatitis or chronic liver disease

          5. history of psychotic disorders

          6. patients with disorders in the central nervous system

          7. history of other malignancy within 5 years

          8. history of clinically significant heart disease (congestive heart failure, symptomatic
             coronary artery disease, symptomatic arrhythmia, myocardial infarction)

          9. patients with increased bleeding tendency

         10. pregnant or lactating female patients

         11. patient who did not agreed and signed to the informed consent form
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment