Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Multi-dimensional Clinical and Pathophysiological Profiles of Patients With Functional Dyspepsia and Effect of Gut Microbiota Manipulation Using Rifaximin for Its Treatment

Eligibility criteria:
Inclusion Criteria:

          -  FD diagnosis by ROME IV criteria (one or more of bothersome symptoms like postprandial
             fullness, early satiation, epigastric pain, and epigastric burning. It must include
             criteria for postprandial distress syndrome and epigastric pain syndrome for the last
             3 months with symptom onset at least 6 months before diagnosis and no evidence of
             structural disease, including upper endoscopy).

          -  No organic disease on upper gastrointestinal endoscopy and ultrasound.

          -  Currently, not on any active therapy during the last two months.

          -  No previous history of Helicobacter pylori eradication.

          -  No antibiotic therapy within the last month.

          -  Not received proton pump inhibitors for a minimum of 4 weeks prior to study
             enrollment.

        Exclusion Criteria:

          -  Presence of alarm symptoms such as GI bleeding, unexplained iron deficiency anemia,
             unintentional weight loss, palpable abdominal mass, family history of colon or stomach
             cancer or symptom onset ≥50 years of age and not yet screened for colon cancer, or
             sudden/acute onset of a new change in bowel habit)

          -  No proper informed consent.

          -  Endoscopic treatment for gastroesophageal reflux.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The Evaluation of Hemostasis in Hospitalized COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  · Confirmed diagnosis of COVID-19 infection using a positive RT-PCR or a positive IgG
             antibody test prior to or during hospitalization or,

             · With a negative COVID-19 RT-PCR test but with symptoms of possible COVID-19
             infection and:

          -  elevated D-dimer and/or

          -  positive imaging results showing unilateral or bilateral pneumonia or ground-glass
             opacity in lungs · The subject or legal authorized representative able to read and
             sign an informed consent document including authorization permitting release of
             personal health information approved by the investigator's Institutional Review Board
             (IRB).

        Exclusion Criteria:

        Subjects will be excluded from entry if ANY of the criteria listed below are met:

          -  Less than 3 years of age

          -  Subject is pregnant

          -  Active treatment for cancer

          -  History of long-term use of immunosuppressive agents

          -  History of severe chronic respiratory disease and requirement for long-term oxygen
             therapy

          -  Patients undergoing hemodialysis or peritoneal dialysis

          -  Patients on full dose anticoagulant at the time of enrollment

          -  Any condition unsuitable for the study as determined by investigators
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Efficacy and Safety of HIP1601 Capsule

Eligibility criteria:
Inclusion Criteria:

          -  19≤ age ≤ 75

          -  Esophago-Gastro-Duodenoscopy LA classification ≥ grade A

          -  Patients experienced heartburn or acid regurgitation within 7 days of screening day

          -  Patients understood the consents and purpose of this trial and signed consent form

        Exclusion Criteria:

          -  Has malignancy in the upper gastrointestinal tract, digestive ulcer, bleeding disorder
             or signs of gastrointestinal bleeding

          -  Has a severe liver disorder(at screening day, AST or ALT level exceeds 3 times more
             than normal upper range)

          -  Has a clinically significant renal failure(at screening day, MDRD eGFP ≤ 59
             mL/min/1.73m2 or Serum creatinine >2.0mg/dL)

          -  Uncontrolled diabetes mellitus

          -  Before screening EGD, a patient who has taken H2-receptor antagonist or PPI within 2
             weeks

          -  Before screening EGD, a patient who has taken drugs containing following list within 1
             weeks : warfarin, anticholinergics for spasmolytic GI, antineoplastic agents,
             salicylates(except 100mg a day for prevention of cardiovascular disease), steroids,
             propulsives, sucralfate, NSAIDs, other antacids(e.g. antacids of prostaglandin
             analogs, antacids of aluminum/magnesium)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Diode Laser Versus Topical Corticosteroids in Management of Oral Ulcers in Behcet's Disease

Eligibility criteria:
Inclusion Criteria:

          -  patients diagnosed with Behcet's Disease according to International Criteria for BD.

          -  patients with active oral ulcers.

          -  patients free from any visible oral lesions other than the oral ulcers of BD.

          -  patients who agreed to take the supplied interventions.

          -  patients who will agree to participate in the study.

          -  patients who will accept to sign the informed consent.

        Exclusion Criteria:

          -  patients not physically able to participate in survey or clinical oral examination.

          -  patients with organ or life-threatening disease.

          -  patients with history of a severe or chronic medical condition including tuberculosis,
             hepatitis and human immunodeficiency virus.

          -  patients under immunosuppressive drugs.

          -  patients with organ transplantation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children

Eligibility criteria:
Inclusion Criteria:

          -  Gastro-oesophageal reflux unresponsive to medical treatment, or those who had serious
             complications (e.g. apnoea, aspiration pneumonia, oesophagitis)

        Exclusion Criteria:

          -  Patients who had previous anti-reflux surgery, previous open abdominal surgery, if
             parents declined to participate into study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Study of the Use of Laser Light to Treat Osteoarthritis of the Hand.

Eligibility criteria:
Inclusion Criteria:

          -  Clinical and radiographic diagnosis of osteoarthritis of the hand.

          -  Hand symptoms such as pain, aching and stiffness present across the prior six months.

          -  Willingness to use only Tylenol to relieve hand symptoms during the study.

          -  Primary spoken language is English.

        Exclusion Criteria:

          -  Current use of narcotics, opiates, morphine, steroids.

          -  Previous surgery to the hand.

          -  Infection or wound in the hand.

          -  Involvement in litigation, worker's compensation claim or receiving disability
             benefits because of osteoarthritis of the hand.

          -  Participation in a research study during the prior 90 days.

          -  Pregnant or lactating.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Use of Platelet Rich Plasma (PRP) for Improving Thin Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  women with thin endometrium

        Exclusion Criteria:

          -  serum positive hepatitis B and C women
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparing Pain After Laparoscopic Hernia Repair Using Two Different Types of Mesh Fixation

Eligibility criteria:
Inclusion Criteria:

          -  Patients scheduled for elective, inguinal hernia repair

          -  18 years or older

          -  Male gender

          -  ASA physical classification system 1-3

          -  Informed consent

        Exclusion Criteria:

          -  Patients with recurrent hernia, except patients operated in childhood without mesh
             application.

          -  Patients with bilateral hernia

          -  Patients with chronic pain

          -  Patients in anticoagulation therapy

          -  Previous major surgery in lower abdomen
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Collaborative Consultation for Participation Among Students With IDD

Eligibility criteria:
Inclusion Criteria:

          1. A diagnosis of moderate IDD

          2. Mobility independence

          3. No secondary diagnosis of autism, nor sensory disabilities such as blindness or
             deafness

          4. Students had been studying at the school for at least one year prior to data
             collection.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Entailment