Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Osteoarthritis Topical Treatment

Eligibility criteria:
Main Inclusion Criteria:

          -  Male or female patients aged at least 40 years.

          -  Primary osteoarthritis in a single knee joint, grade II/III based on the Kellgren and
             Lawrence classification system.

          -  Radiographic evidence consistent with osteoarthritis carried out within 6 months
             before screening.

          -  pain is currently not adequately controlled with a simple analgesic or an NSAID OR
             would necessitate treatment, but is not yet treated.

        Main Exclusion Criteria:

          -  Concomitant presence of another type of continuous pain that is more severe in
             intensity in comparison with the osteoarthritis target joint pain

          -  Osteoarthritis causing significant pain in any joint other than the identified knee,
             or contralateral knee (≥ 20 mm pain) as confirmed by a separate VAS at visit 1 for any
             other painful joint concerned.

          -  Female patients who are pregnant or breast-feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Proprioceptive Thumb Exercises Program in Patients With Carpometacarpal Joint Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of grade I, II or III thumb CMC joint OA in their dominant hand according to
             the Eaton Classification Stage

          -  Pain rating of 4/10 on the Visual Analogue Scale (VAS) during activities of daily
             living (ADLs) at the time of the therapy initial evaluation.

          -  The ability to read and understand the patient information sheets and exercises

        Exclusion Criteria:

          -  Neurological disorder affecting the upper limb.

          -  Had received specific treatment for hand or thumb pain in the same limb in the last 6
             months including an intra-articular joint injection to wrist, fingers, or thumb; -
             Fractures or a significant hand injury or previous surgery to the wrist or hand;

          -  Tenosynovitis and/or Dupuytren disease
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Study Evaluating 13-valent Pneumococcal Conjugate Vaccine in Healthy Japanese Adults Aged >= 50 Years

Eligibility criteria:
Inclusion Criteria:

          -  Japanese descent male and female adults who do not have the potential to bear children
             >= 50 years of age.

          -  Determined to be eligible for the study based on medical history, physical
             examination, and clinical judgment. Subjects with preexisting stable disease, defined
             as disease not requiring significant change in therapy or hospitalization for
             worsening disease 12 weeks before receipt of study vaccine, are eligible.

          -  Sexually active men must agree and commit to use a medically accepted form of
             contraception during the study and for at least 3 months after vaccination.

        Exclusion Criteria:

          -  History of severe adverse reaction associated with a vaccine.

          -  Receipt of any vaccine within 30 days before study vaccination, except influenza
             vaccine.

          -  Documented S pneumoniae infection within the past 5 years before study vaccination.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone

Eligibility criteria:
Inclusion Criteria:

          1. Either possible, probable, or definite ALS, predominantly lower motor neuron disease,
             predominantly upper motor neuron disease, or bulbar

          2. With or without cognitive involvement

          3. Willing to participate

          4. On no experimental treatment

          5. Ages 18 - 85

          6. No prior exposure to Edaravone (Radicava)

          7. On a stable dose of Riluzole for 30 days or off Riluzole

          8. Male or female

          9. Females of childbearing age must use contraception

        Exclusion Criteria:

          1. Unstable medical illness

          2. Abnormal liver function (>2x ULN)

          3. Unlikely to survive for 26 weeks
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Normal Values for Myocardial Left Atrial Strain

Eligibility criteria:
Inclusion Criteria:

          -  No history of cardiopathy / pneumopathy.

          -  No history of hypertension or mellitus diabetes.

        Exclusion Criteria:

          -  Pregnancy.

          -  Athletes.

          -  Body mass index < 16 or => 30 kg/m2.

          -  Previous treatment with cardiotoxic chemotherapy.

          -  Dilated left ventricle (telediastolic diameter index > 30 mm/m2).

          -  Interventricular septal thickness => 12 mm.

          -  Dilated left atria (volume => 31 ml/m2).

          -  Systolic pulmonary pressure => 35 mmHg.

          -  Moderate or severe valvulopathy.

          -  Incomplete or suboptimal left atrial visualization.

          -  Frame rate < 50 fps.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Safety and Efficacy of Deferasirox (ICL670) in Patients With Iron Overload Resulting From Hereditary Hemochromatosis

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years of age or older

          -  Male or female patients homozygous for the C282Y mutation.

          -  Iron overload as documented by serum ferritin and transferrin saturation

          -  No known allergy or contraindication to the administration of deferasirox

          -  Ability to comply with all study-related procedures, medications, and evaluations

          -  Effective use of birth control measures.

        Exclusion Criteria:

          -  Iron overload not due to hereditary hemochromatosis

          -  Males with hemoglobin <13 mg/dL, females with hemoglobin <12 mg/dL

          -  Desferal treatment within 1 month of the screening visit

          -  Patients currently or previously treated with deferiprone or deferasirox

          -  Significant medical condition interfering with the ability to partake in this study

          -  Presence of a surgical or medical condition that might significantly alter the
             absorption, distribution, metabolism or excretion of any study drug

          -  Clinical evidence of Active Hepatitis B or C

          -  Positive HIV serology

          -  Pregnant or breast feeding patients

          -  Patients treated with systemic investigational drug within 4 weeks prior or with
             topical investigational drug within 7 days prior to the screening visit

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology

Eligibility criteria:
Inclusion Criteria:

          -  Patients with pregnancy of unknown location (PUL) diagnosed 22 - 27 days after oocyte
             retrieval, at first ultrasound routine control (A "pregnancy of unknown location"
             (PUL) is a term used to classify a women with a positive pregnancy test and an empty
             uterus with no signs of an intrauterine or extrauterine pregnancy on a transvaginal
             ultrasound scan.)

          -  Patients with Intrauterine pregnancy : Viable intrauterine pregnancy (IUP) An
             intrauterine gestational sac containing a fetal pole with visible cardiac activity

          -  Patients with Ectopic pregnancy (Tubal ectopic pregnancy): An empty endometrial cavity
             with: (i) an inhomogeneous adnexal mass or (ii) an empty extrauterine gestational sac
             seen as hyperechoic ring or (iii) an extrauterine gestational sac with a yolk sac
             and/or fetal pole with or without cardiac activity
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Experimental Therapeutics in Essential Tremor Using Transcranial Direct Current Stimulation

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years and < 50 years

          -  Important essential tremor (bilateral postural and/or action tremor since more than
             one year)

          -  Normal physical and neurological examination, except for essential tremor

          -  Insufficient efficiency of usual essential tremor's treatment

          -  No treatment altering the cortical excitability

          -  Agreement to use a medically acceptable method of contraception throughout the study
             for female of childbearing potential

        Exclusion Criteria:

          -  Cervical tremor

          -  Current neurological or psychiatric illness other than essential tremor

          -  Individual who is on medication which is known to lower seizure threshold

          -  Previous history of seizure(s), malaise or current active epilepsy

          -  Contraindication for MRI or TMS study

          -  Pregnancy, breast feeding women and women who are of childbearing age and not
             practicing adequate birth control

          -  Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide
             an informed consent

          -  Simultaneous participation in another clinical trial

          -  Patients who are not enrolled at social security
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Deferoxamine for the Treatment of Hemochromatosis

Eligibility criteria:
-  INCLUSION CRITERIA

        Patients studied under this protocol will be at risk for or have evidence of significant
        excess tissue iron.

        Most patients will be on regular blood transfusion secondary to either congenital or
        acquired anemia.

        The majority of patients have homozygous beta thalassemia.

        Patients with sickle cell anemia will be included only when there is an absolute indication
        for regular blood transfusions (e.g., a history of stroke).

        Twenty to thirty adults with acquired anemia and good long-term prognosis will be accepted
        for study if chelation can be initiated early in their transfusion history (less than 30-50
        units).

        EXCLUSION CRITERIA

        Such patients will be excluded from study if they have diabetes or cardiac disease due to
        another cause (coronary artery or valvular heart disease).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.


Eligibility (NLI label): Entailment