Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Improving Quality of Osteoporosis Care Through Patient Storytelling

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Age 65 or older

          -  At least one visit with a primary care physician in the previous 12 months

        Exclusion Criteria:

          -  DXA scan in the previous 5 years
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Umifenovir in Hospitalized COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18

          -  COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed).

          -  Tympanic Temperature of ≥37.5 AND at least one of the following: Cough, Sputum
             production, nasal discharge, myalgia, headache or fatigue) on admission.

          -  Time of onset of the symptoms should be acute ( Days ≤ 10).

          -  SpO2 ≤ 93%

          -  Respiratory Rate ≥ 22

        Exclusion Criteria:

          -  Refusal to participate expressed by patient or legally authorized representative if
             they are present.

          -  Patients with prolonged QT or PR intervals, Second or Third Degree heart block,
             Arrhythmias including torsade de pointes

          -  Patients using drugs with potential interaction with Umifenovir Hydroxychloroquine,
             Lopinavir/Ritonavir or Interferon-β 1a.

          -  Pregnant or lactating women.

          -  History of alcohol or drug addiction in the past 5 years.

          -  Blood ALT/AST levels > 5 times the upper limit of normal on laboratory results.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Comparison of Two Different Wrist Immobilization Methods

Eligibility criteria:
Inclusion Criteria:

          -  Being an office worker between 20-35 years of age

          -  Using a computer for at least 4 hours a day

          -  Working full time for at least 1 year without any upper extremity pathology

        Exclusion Criteria:

          -  Having a body mass index of 30 kg / m2 or more on the day of evaluation

          -  Using muscle relaxants 72 hours before the evaluation

          -  Exercising within the last 48 hours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Deep Brain Stimulation for the Treatment of Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable AD according to the National Institute of Neurological and
             Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders
             Association (NINCDS-ADRDA) criteria

        Exclusion Criteria:

          -  Has significant neurological disease, other than Alzheimer's disease, e.g., multiple
             sclerosis, Parkinson's disease and ischemic stroke, or severe brain atrophy or the
             presence of subdural hygromas or subdural hematomas.

          -  Evidence of substance abuse (alcohol or other drug) abuse or dependence during the
             previous 12 months (DSM-IV Criteria).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Laryngeal Mask Insertion Conditions And Hemodynamic Effects

Eligibility criteria:
Inclusion Criteria:

          -  ASA physical status I or II who were scheduled to minor elective ambulatory surgery
             (e.g. inguinal hernia, undescended testes, umbilical hernia) performed by experienced
             surgeon under general anesthesia.

        Exclusion Criteria:

          -  patients with full stomach

          -  A history of gastric reflux

          -  A history of convulsions, cardiovascular or neuromuscular disease

          -  Allergies to the study drugs

          -  obese children

          -  suspected difficult airway and hyper-reactive airway disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 8 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Eligibility criteria:
Patients:

        Inclusion criteria

          -  18 years and over

          -  Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop
             (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level,
             marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds
             (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes

        Exclusion criteria

          -  Treatment with topical ciclosporin

          -  Autologous serum treatment

          -  Wearer of scleral lenses

          -  Known pregnancy or breastfeeding

        Control subjects:

        Inclusion criteria

          -  18 years and over

          -  Tear Break Up Time > 5 seconds (fluorescein test)

        Exclusion criteria

          -  Wearer of contact lenses

          -  Functional ocular signs

          -  Anomalies of the ocular surface observed during examination with the slit lamp

          -  Fluorescein staining of the ocular surface (cornea, conjunctiva)

          -  Topical ocular treatment

          -  Known pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy of Radial Shockwave Therapy for Treatment of Pain in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical and radiological diagnosis of primary knee diagnosis.

          -  Pain intensity: Visual Analog Scale (VAS) ≥ 6;

          -  One of more failures with conventional treatment (drugs, Non-Steroidal
             Anti-inflammatory Drugs - NSAD, physiotherapy, stretching, acupuncture, orthosis and
             others);

          -  Age over 60 years;

          -  No use of corticosteroids in the prior 48 hours;

          -  No major osteoarthritis events in other joints of lower limbs (waist and ankle) and
             lower back;

          -  No clinical evidence of related neuropathy, including radiculopathy and peripheral
             neuropathy;

          -  Absence of systemic inflammatory disease (Rheumatoid arthritis, Reiter, ankylosing
             spondylitis, generalized polyarthritis, cancer);

          -  Absence of infection or cancer at the application site;

          -  Absence of related endocrine and metabolic diseases;

          -  Absence of fibromyalgia, diagnosed after the American College of Rheumatology, 1999;

          -  Absence of severe blood dyscrasias;

          -  Absence of severe psychiatric disturbances that requires psychiatric assessment;

          -  Availability to comply with the clinic visits and follow up evaluations along the
             treatment

        Exclusion Criteria:

          -  Patients who withdraw the informed consent form at any time
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Assessment of Day-night Secretion of Progesterone and LH Across Puberty

Eligibility criteria:
Inclusion Criteria:

          -  Early and late pubertal girls with normal androgens

          -  Early and late pubertal girls with hyperandrogenemia

          -  All subjects will be girls from pre-puberty (Stage 1 breast development and pubic hair
             growth but at least 7 years old) to 7 years post menarche.

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin <11.5 g/dL for non-African American subjects; Hemoglobin < 11.0 g/dL for
             African American subjects

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism (reflected by persistently abnormal TSH values)

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-OHP > 200 ng/ml (in girls without a previous diagnosis of
             congenital adrenal hyperplasia)

          -  DHEA-S > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 25 kg
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Growth Hormone (GH) Deficiency & Insulin Like Growth Factor 1 (IGF-I)/ Insulin Like Growth Factor Binding Protein 3 (IGFBP-3) Ratio

Eligibility criteria:
Inclusion Criteria:

          -  children presented to Jordan Univeristy Hospital (JUH) outpatient endocrinology clinic
             for the evaluation of short stature (SS)

        Exclusion Criteria:

        (i) their parents could not provide written consent for them; (ii) they were lost to follow
        up; (iii) they could not perform clonidine stimulation tests (CST) or insulin tolerance
        test (ITT) due to a medical contraindication (e.g. cardiac disorder, seizure disorder);
        (iv) they had received GH therapy in the past; (v) they were known to have pituitary
        diseases, hypothyroidism, hypogonadism or discovered to have panhypopituitarism or (vi)
        they have malnutrition, diabetes mellitus, liver disease, or other chronic illnesses.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Novel Therapies for Essential Tremor

Eligibility criteria:
1. Diagnosis of essential tremor.

          2. Tremor rating scale score 3 or one or both upper extremities

          3. Unsatisfactory response to primidone or to propanolol

          4. Not taking tremor-inducing drug

          5. Able to comply with visits
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment