Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Endoscopy Survey

Eligibility criteria:
Inclusion Criteria:

          -  physicians working in endoscopy units worldwide

        Exclusion Criteria:

          -  physicians not working in endoscopy units worldwide
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Wrist-used Blood Pressure Monitor Clinical Test (Cuff Range: 14cm-25cm)

Eligibility criteria:
Inclusion Criteria:

          -  wrist circumference: 14 cm-25 cm

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 23 Years old.
Subject must be at most 81 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Short Stature Related Distress

Eligibility criteria:
Inclusion Criteria:

        1 Segment 1 :Boys at the age range of 8-13 years 2. Segment 2: Boys at the age range of
        12-17 years 3. Tanner stage 1 (segment 1 only) 4. more than 2 SD's (standard deviation)
        below the average height

        Exclusion Criteria:

          1. Mental retardation,

          2. Psychiatric illness,

          3. Lack of informed consent\assent.

          4. Health status that required chronic treatment with steroids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Study on Laparoscopic D2 Lymphadenectomy Plus Complete Mesogastrium Excision（D2+CME）for Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

        Age from over 18 to under 75 years Primary gastric adenocarcinoma (papillary, tubular,
        mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by
        endoscopic biopsy cT2-4a, N0-3, M0 at preoperative evaluation according to the AJCC Cancer
        Staging Manual Seventh Edition Expected curative resection through gastrectomy with D2
        lymphadenectomy Performance status of 0 or 1 on ECOG (Eastern Cooperative Oncology Group)
        scale ASA (American Society of Anesthesiology) score class I, II, or III Informed consent
        obtained from patients or their appointed agent

        Exclusion Criteria:

        Patients treated with neoadjuvant chemotherapy or radiation therapy; Patients with history
        of upper abdominal surgery; History with other severe comorbidities and cannot tolerate
        laparoscopic surgery, such as severe heart and lung diseases, heart function below clinical
        stage 2, pulmonary infection, moderate to severe COPD, chronic bronchitis, severe diabetes
        and / or renal insufficiency, severe hepatitis and / or function below the rank of CHILD B
        grade, and severe malnutrition, etc; Patients suffering from malignant diseases before the
        study or with other gastric malignant diseases, such as lymphoma and stromal tumors, etc.;
        Pregnant woman and woman during lactation; Patients with mental sickness; The patient
        compliance is bad or the researcher expect there will not be good patient compliance;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Phase I/II Study of SRP-4053 in DMD Patients

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with DMD, genotypically confirmed.

          -  Intact right and left biceps muscles or an alternative upper arm muscle group.

          -  Stable pulmonary and cardiac function.

          -  Minimum performance on 6MWT, North Star Ambulatory Assessment, and rise (Gowers) test
             as specified in the study protocol.

          -  On a stable dose of corticosteroids for at least 6 months.

        Exclusion Criteria:

          -  Previous treatment with the experimental agents BMN-195 (SMT C1100) or PRO053.

          -  Current or previous treatment with any other experimental treatments within 12 weeks
             prior to study entry.

          -  Major surgery within the last 3 months.

          -  Presence of other clinically significant illness.

          -  Major change in physical therapy regime within the last 3 months.

        Other inclusion and exclusion criteria may apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria (1 of the following):

          -  Completed insulin tolerance testing (ITT) at University of Michigan from 2012 to
             present.

          -  Are scheduled to complete ITT.

          -  Are clinically suspected to have adrenal insufficiency but have not undergone ITT.

        Exclusion Criteria:

          -  Female patients who are of child-bearing potential (defined as a sexually mature woman
             who has not undergone hysterectomy, bilateral oophorectomy bilateral salpingectomy or
             bilateral tubal ligation/occlusion, at least 12 weeks prior to screening, or who has
             not been naturally postmenopausal for at least 24 consecutive months prior to study
             enrollment) and not using non-hormonal contraception.

          -  Female patients not willing to use non-hormonal contraception for one month following
             treatment.

          -  Women who are pregnant or breast feeding.

          -  Patients with an existing diagnosis of adrenal insufficiency who are on any
             glucocorticoid replacement other than oral hydrocortisone or prednisone.

          -  Patients on medications that are strong CYP3A

          -  Patients taking other medications metabolized by CYP3A

          -  Patients who have a history of QT prolongation and patients with any recent abnormal
             electrocardiogram (ECG).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Healing of Post-ext Sites Using Bovine Bone Mineral: a CBCT and Histologic RCCT

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adult patients with one or more teeth to be extracted, from premolar to
             premolar

        Exclusion Criteria:

          -  Heavy smokers (more than 10 cig per day)

          -  Current Pregnant patients

          -  History of malignancy

          -  History of radiotherapy or chemiotherapy in the past 5 years

          -  Long term steroidal or antibiotic therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Effect of CoVid-19 (CoronaVirusDisease-19) and Exercise on Myocardial Fibrosis and Ventricular Arrhythmias

Eligibility criteria:
Inclusion Criteria:

          -  Athletes (professional or recreational but aiming to compete at a national or
             international level), performing mixed-type or endurance sports as defined by
             Pelliccia et al. who:

               1. have recovered from a proven (either by PCR (Polymerase Chain Reaction), serology
                  or chest Computed Tomography) COVID-19 infection

               2. are more than 1-month post onset of symptoms or the first positive PCR and

               3. are willing to start (or are) exercising again

        Exclusion Criteria:

          1. known prior cardiac fibrosis

          2. known or newly diagnosed coronary artery disease

          3. allergy or contraindications for gadolinium contrast.

          4. unwillingness or impossibility to give informed consent

          5. Presence of edema on the CMR
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Use of a TGA and TEM in the Assessment of the Efficacy of Treatment With APCC or rFVIIa

Eligibility criteria:
Inclusion Criteria:

          -  patients with acquired haemophilia

          -  patients with congenital haemophilia A with inhibitor

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: High-intensity Focused Ultrasound in Treatment of Uterine Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  Age >40 years old, with no future childbearing plans

          -  Age >30 years old, who has tubal sterilization

          -  Significant symptoms related to adenomyosis, intractable to standard medical therapy,
             or patient considering radiological intervention (uterine fibroid embolization) or
             surgery.

          -  Clinical uterine size less than 20 weeks gestation

          -  Localized adenomyotic lesion or adenomyoma identified of less than 10 cm in diameter
             as judged by contrast MRI, involving only anterior or posterior uterine wall and not
             both.

          -  No laparotomy scars.

          -  Women should be able to give consent.

        Exclusion Criteria:

          -  Other pelvic or uncontrolled systemic diseases

          -  Confirmed or suspected pregnancy

          -  Patients who are unable to communicate with researchers during the treatment

          -  Patients who are contraindicated for MRI examination

          -  Patients with thick abdominal wall (>5 cm, as measured by MRI)

          -  Presence or history of acute pelvic inflammatory disease or any pelvic malignancy

          -  History of lower abdominal surgery, known severe pelvic endometriosis and/ or
             extensive pelvic adhesion

          -  Presence of significant sized fibroids which may interfere with the treatment or
             affect the outcome measures
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment