Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/UK-506)

Eligibility criteria:
Main inclusion criteria:

          -  Written informed consent

          -  Outpatients of at least 18 years of age

          -  GERD

          -  Patients with symptoms of GERD

        Main exclusion criteria:

          -  Signs, indicating other gastrointestinal diseases

          -  Other concomitant diseases

          -  Special restrictions for female patients

          -  Previous medication

          -  Concomitant medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Effect of Iron Reduction by Phlebotomy for Type 2 Diabetes

Eligibility criteria:
Inclusion Criteria:

          -  Age 35-65

          -  Prediabetes, or diabetes relatively well-controlled (Hemoglobin A1c [HbA1c] ≤ 8.0%)
             with a single oral agent as defined by oral glucose tolerance testing (OGTT) using
             criteria of the American Diabetes Association.

          -  Serum ferritin values in the upper 50% of the normal range, 110-400 ng/mL for males,
             or 80-240 for females.

        Exclusion Criteria:

          -  hereditary hemochromatosis;

          -  cancer (except cases currently with no evidence of disease);

          -  serum creatinine >1.5;

          -  anemia (Hgb < lower limit of normal);

          -  chronic inflammatory conditions (rheumatologic conditions such as rheumatoid arthritis
             or giant cell arteritis, or chronic infections such as hepatitis B or C) that could
             affect ferritin;

          -  erythrocyte sedimentation rate or C-reactive protein>1.5 times the upper limit of
             normal (UNL);

          -  serum transaminases 2 x UNL;

          -  hemophilia,

          -  warfarin therapy,

          -  history of GI bleeding;

          -  current glucocorticoid therapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Exploration of Patient Ethics and Communication Excellence (PEACE) Rounds

Eligibility criteria:
Inclusion Criteria:

          1. An employee of AdventHealth (AH), or a physician with privileges there, who has
             participated in PEACE Rounds at AdventHealth.

          2. Over the age of 18

          3. Able to provide informed consent

          4. Must speak and understand English

        Exclusion Criteria:

        1. Discernable cognitive impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Hearing Study: Sensitivity to Features of Speech Sounds

Eligibility criteria:
Inclusion Criteria:

          -  Normal hearing, mild or moderate symmetric sensorineural hearing loss.

        Exclusion Criteria:

          -  Asymmetric hearing thresholds (more than 15 decibels (dB) threshold difference between
             the two ears at any frequency up to 4 kHz).

          -  Severe hearing loss (greater than 60 dB hearing thresholds at any frequency up to 4
             kHz).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity

Eligibility criteria:
Inclusion Criteria:

          -  Biological profile suggestive of hepcidin deficiency:

               -  increase of transferrin saturation coefficient (> 50 %) verified on at least 2
                  times, and calculated from the transferrinemia.

               -  Proved hepatic iron overload: by the dosage of the iron hepatic concentration
                  either on block hepatic biopsic, or by MRI according to the method of
                  quantification of the iron validated overload (by adopting a threshold of 100
                  µmol /g)

               -  Patient's written consent for examination of genetic characteristics for
                  diagnosis and collection development for genetic and not genetic research within
                  the framework of an abnormality of the iron metabolism

               -  Patient written inform consent.

        Exclusion Criteria:

          -  HFE hemochromatosis: homozygosity C282Y/C282Y

          -  Treatment with iterative phlebotomy

          -  Hematologic diseases with dyserythropoiesis and/or repeated transfusions

          -  Haptoglobin low, below normal directing towards the diagnosis of chronic hemolysis,
             myelodysplasia

          -  Prolonged oral or parenteral iron supplementation

          -  Current or past excessive regular drinking

          -  Patient minor or under legal protection measure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Use of Wearable Tech to Increase Physical Activity in Inpatient Rehabilitation for Patients With Chronic Pain

Eligibility criteria:
Inclusion Criteria:

          -  taking part in inpatient rehabilitation at Unicare Helefort Rehabilitation center for
             chronic pain.

        Exclusion Criteria:

          -  not having a smartphone (will not be able to access the mobile application).

          -  using a wheelchair (the technology will be not able to measure activity correctly)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic hemodialysis

          -  Elevated serum ferritin with low to normal transferrin saturation (TSAT)

          -  Moderate to severe anemia

          -  Receiving epoetin alfa treatment

        Exclusion Criteria:

          -  Known sensitivity to Ferrlecit®

          -  Medical conditions that would confound the efficacy evaluation

          -  Recent blood transfusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Cardiovascular Status in Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  Chronic primary adrenal insufficiency

          -  Adequate hormone replacement therapy (>3 years)

          -  Age >18 years

          -  Patient's informed consent

        Exclusion Criteria:

          -  Hormone replacement therapy with an other glucocorticoid than hydrocortisone

          -  Pharmacotherapy with glucocorticoids

          -  Congenital adrenal hyperplasia

          -  Coronary heart disease

          -  Heart failure

          -  Systemic disease with (potential) cardiac involvement (e.g. amyloidosis, lung
             fibrosis)

          -  Pregnancy

          -  Chronic alcohol abuse

          -  Malignant disease

          -  Arterial hypertension

          -  Chronic renal failure (MDRD <60)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Age group of 3-25 years

          -  Duchenne muscular dystrophy diagnosed on the basis of clinical presentation

        Exclusion Criteria:

          -  Respiratory Distress

          -  Acute infections such as Human Immunodeficient Virus/Hepatitis B Virus/Hepatitis C
             Virus malignancies

          -  Acute medical conditions such as respiratory infections, fever, hemoglobin less than 8
             bleeding tendency, bone marrow disorder, left ventricular ejection fraction < 30%

          -  Pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy

Eligibility criteria:
Main Inclusion Criteria:

          -  Ambulatory or non-ambulatory

          -  Diagnosis of DMD with confirmation of minimal to no dystrophin

          -  Corticosteroid naive or on therapy for at least 12 months (stable dose and regimen)

        Main Exclusion Criteria:

          -  Recent, substantial change in use of cardiac medications or medications affecting
             muscle function

          -  Inability to undergo magnetic resonance imaging (MRI)

          -  Significantly compromised cardio-respiratory function

          -  Prior treatment with another investigational product in past 6 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Entailment