Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Treatment of Sexual Dysfunction in Hypogonadal Men With Epilepsy With Testosterone and Either Anastrozole or Placebo

Eligibility criteria:
Inclusion Criteria:

          -  Subject must be a male between the ages of 18 and 50 years.

          -  Subject must have localization-related epilepsy with complex partial and/or secondary
             generalized seizures.

          -  Subject will meet criteria for hypogonadism (abnormally low bioactive testosterone
             levels and abnormally low scores on questionnaires of reproductive and sexual
             function).

          -  Subject will have had a normal urogenital and rectal/prostate exam during the year
             prior to entry.

          -  Subject will have had documentation of therapeutic range serum AED levels, a normal
             CBC, and hepatic enzyme (ALT,AST, alkaline phosphatase) levels that are less than
             twofold elevated during the 6 months prior to entry.

        Exclusion Criteria:

          -  Subject that has taken hormones, major tranquilizers or antidepressants in the three
             months prior to entry.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Prospective Study of an Investigational Daily Disposable Contact Lens

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with normal eyes who are not using any ocular medications.

          -  Be of legal age of consent and sign Informed Consent document. If under legal age of
             consent, legally authorized representative must sign Informed Consent document and
             subject must sign Assent document.

          -  Willing and able to wear spherical contact lenses for at least 5 days per week.

          -  Willing and able to wear spherical contact lenses within the available range of powers
             of -1.00 diopter(D) to -6.00D in 0.25D steps.

          -  Best spectacle-corrected visual acuity greater than or equal to 20/25.

          -  Manifest cylinder less than or equal to 0.75D.

          -  Other protocol-defined inclusion criteria may apply.

        Exclusion Criteria:

          -  Any active anterior segment ocular disease that would contraindicate contact lens
             wear.

          -  Any use of systemic medications for which contact lens wear could be contraindicated
             as determined by the investigator.

          -  History of refractive surgery or irregular cornea.

          -  History of pathologically dry eye.

          -  Eye injury within twelve weeks immediately prior to enrollment for this trial.

          -  Currently enrolled in any clinical trial.

          -  Participation in a contact lens or contact lens care product clinical trial within the
             previous 30 days.

          -  Other protocol-defined exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Simple Decompression Versus Anterior Transposition of the Ulnar Nerve

Eligibility criteria:
Inclusion Criteria:

          -  Men or women aged 16 to 60 years of age

          -  Displaced, distal humerus fracture (OTA 13A or 13C) as seen in radiographs

          -  Fractures ≤ 28 days post injury

          -  Closed fractures

          -  No history of previous ulnar neuropathy or elbow pathology

          -  Provisin of informed consent

        Exclusion Criteria:

          -  Vascular injury

          -  History of previous ulnar neuropathy or elbow pathology

          -  Fractures more than 28 days post-injury

          -  Limited life expectancy due to significant medical co-morbidity or medical
             contraindication to surgery

          -  Inability to comply with rehabilitation or form completion

          -  Likely problems, in the judgement of the investigators, with maintaining follow-up
             (i.e. patients with no fixed address, patients not mentally competent to give consent,
             etc.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: The Effects of Radial and Focused Extracorporeal Shock Wave Therapies on Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of lateral epicondylitis

          -  be aged ≥18 at the time of diagnosis

          -  be give informed consent

        Exclusion Criteria:

          -  be have not completed the assessment process.

          -  elbow deformity

          -  psychological illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: EffeKt Taiwan- Efficacy and Safety of Long-term Treatment With KOGENATE® FS in Taiwan

Eligibility criteria:
Inclusion Criteria:

          -  Patients with diagnosis of hemophilia A, independent of age, treated with KOGENATE FS
             as their only source of FVIII, decision taken by the investigator to administer
             KOGENATE FS. For pretreated patients with more than 100 exposure days an inhibitor
             assessment within three months prior to enrollment should be available; for pretreated
             patients with less than 100 exposure days an inhibitor assessment at baseline should
             be available.
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Overweight Management and Social Inequalities

Eligibility criteria:
Inclusion criteria

          -  Attending grade 9 or 10 in one of the 35 state-run school of the Vosges department and
             be in a general, technological or vocational course,

          -  Aged ≤ 18 years old,

          -  not giving written refusal to participate in the trial,

          -  able to complete a questionnaire,

          -  overweight or obese according to the IOTF criteria (for BMI) and the McCarthy criteria
             (for waist circumference) and/or have a high eating disorder score, and/or express the
             need for management of excess weight,

          -  confirmed as corresponding to the 4 previous inclusion criteria by the physician, with
             elimination of adolescents with false-positive BMI (particularly athletic
             adolescents),

          -  agree to an overweight and obesity care management program.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A Randomized, Double-blind, Placebo-controlled Study of SRP-9001 for Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
Inclusion Criteria:

          -  Established clinical diagnosis of DMD and documented dystrophin gene mutation of DMD
             phenotype.

          -  Indication of symptomatic muscular dystrophy by protocol-specified criteria.

          -  Ability to cooperate with motor assessment testing.

          -  Stable dose equivalent of oral corticosteroids for at least 12 weeks.

        Exclusion Criteria:

          -  Impaired cardiovascular function on ECHO.

          -  Prior or ongoing medical condition on physical examination, ECG, or laboratory
             findings that could adversely affect subject safety, compromise completion of
             follow-up, or impair assessment of study results.

          -  Exposure to another investigational drug or exon skipping medication within 6 months
             of screening.

          -  Exposure to an investigational or commercial gene therapy product.

          -  Abnormal liver or renal function by protocol-specified criteria

        Other inclusion/exclusion criteria apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Efficacy of TGF for Treating Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          1. age between 50~75 years old

          2. diagnosis of osteoarthritis: The Clinical/Radiographic classification criteria of
             American College of Rheumatology, ACR

          3. chronic knee pain over 3 months.

        Exclusion Criteria:

          1. the past history with systemic joint disease, such as autoimmune disease

          2. the patient with history of knee surgery or waiting for the total knee replacement

          3. any disease that affect the function of lower extremities, such as trauma, tumor or
             compensation of abnormal posture

          4. the condition that cannot participate this study

          5. the subjects non-compliance with the protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Mesh Position and Outcomes Following Inguinal Hernia Repair Using an MRI Visible Hernia Mesh

Eligibility criteria:
Inclusion Criteria:

          -  Male patients with a primary symptomatic unilateral inguinal hernia.

          -  Patients eligible to undergo hernia repair either by minimally invasive (TEP, TAPP) or
             open techniques (e.g. Lichtenstein) as judged by the treating surgeon

          -  Written informed consent

        Exclusion Criteria:

          -  Previous inguinal hernia repair

          -  Bilateral inguinal hernia

          -  Femoral hernia repair

          -  Repair in local anesthetics,

          -  Previous abdominal surgery

          -  Children

          -  Emergency surgery, e.g. incarcerated hernias

          -  Contraindication for MRI scans (e.g. Pacemakers and similar implants, cochlea
             implants, claustrophobia)

          -  Contraindications to usage of mesh e.g. known hypersensitivity or allergy

          -  Women who are pregnant or breast feeding

          -  Inability to follow the procedures of the study, e.g. due to language problems,
             psychological disorders, dementia

          -  American Society of Anesthesiologists (ASA) classification higher or equal to 3
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment