Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: A Trial of EBUS-TBNA Versus Conventional TBNA in Diagnosis of Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

        Consecutive patients presenting with clinicoradiological features suggestive of sarcoidosis
        and an indication for transbronchial needle aspiration

        Exclusion Criteria:

          -  Pregnancy

          -  Hypoxemia (SpO2 <90%) on room air

          -  Poor lung function (forced expiratory volume in first second [FEV1] <1L)

          -  Patients with deranged clotting profile (prothrombin time >3 seconds above control;
             activated partial thromboplastin time >10 seconds above control, platelet count
             <50000/µL)

          -  Patients already initiated on glucocorticoids

          -  Diagnosis of sarcoidosis possible on minimally invasive techniques such as skin biopsy
             or peripheral lymph node biopsy and failure to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases

Eligibility criteria:
Inclusion Criteria:

          -  Provision of signed written informed consent from the patient's guardian

          -  Patients aged ≥ 1 year to 14 years old

          -  Patients who have a diagnosis of or suspected to have GU, DU, AU, NERD, RE or
             Zollinger-Ellison syndrome.

        Exclusion Criteria:

          -  Patients less than 10 kg in weight.

          -  Use of any other investigational compounds or participations in another clinical trial
             within 4 weeks prior to the randomisation/registration.

          -  Significant clinical illness within 4 weeks prior to the registration

          -  Presence of hepatic diseases or other conditions that could interfere with evaluation
             of the study as judged by the investigators.

          -  Positive for pregnancy test by urinary or lactation for post-menarchal females.

          -  Previous total gastrectomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Oral Androgens in Man-4: (Short Title: Oral T-4)

Eligibility criteria:
Inclusion Criteria:

          -  Males between 18 to 55 years of age

          -  In good general health based on normal screening evaluation (consisting of a medical
             history, physical exam, normal serum chemistry, hematology, and baseline hormone
             levels)

          -  Subject must agree not to participate in another research drug study for the duration
             of the study

          -  Subject must agree to not donate blood during the study

          -  Subject must be willing to comply with the study protocol and procedures

        Exclusion Criteria:

          -  Men in poor general health, with abnormal blood results (clinical laboratory tests or
             hormone values)

          -  A known history of alcohol or drug abuse

          -  A history of testicular disease or severe testicular trauma,

          -  A history of bleeding disorders or current use of anti-coagulants

          -  A history of sleep apnea and/or major psychiatric disorders

          -  A body-mass index greater than 35,

          -  A history of or current use of testosterone

          -  Infertility
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Yinhu Qingwen Decoction for the Treatment of Mild / Common CoVID-19

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥18 years at time of signing Informed Consent Form.

          2. Laboratory (RT-PCR) confirmed infection with CoVID-19.

          3. Hospitalised with Fever(≥36.7℃ -axilla or oral temperature ≥ 38.0 ℃ or ≥38.6°C
             tympanic or rectal) and cough;

          4. No difficulty swallowing oral medications.

          5. Must agree not to enroll in another study of an investigational agent prior to
             completion of Day 28 of study.

        Exclusion Criteria:

          1. Allergies, known to be allergic to research drugs or drug excipients;

          2. Patient weight is less than 40 kg;

          3. Respiratory distress-RR≥30 / min on room air,or SPO2≤ 93%, or PaO2/FiO2 ≤300mmHg
             (1mmHg = 0.133kPa)

          4. Shock;

          5. The clinician judges that ICU monitoring treatment is needed;

          6. Patients who have participated in other clinical trials within 1 month;

          7. Known patients with impaired renal function (estimated creatinine clearance <60 mL /
             min (male: Cr (ml / min) = (140-age) × body weight (kg) / 72 × blood creatinine
             concentration (mg / dl); female: Cr (ml / min) = (140-age) × weight (kg) / 85 × blood
             creatinine concentration (mg / dl));

          8. During the screening or within 24 hours before screening, patients were found to have
             any of the following laboratory parameter abnormalities (based on local laboratory
             reference range):-ALT or AST level> 5 times the upper limit of normal range (ULN)
             or-ALT or AST > 3 times ULN and total bilirubin levels> 2 times ULN;

          9. Being pregnant or breastfeeding, or having a positive pregnancy test at the time of
             pre-dose inspection, or planning to become pregnant within 3 months of study
             treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Alzheimer Disease

          -  Living independently at home (not in a care home or similar aged care facility)

          -  Able to complete questionnaires in Norwegian

          -  Able to undergo MRI scans

          -  Able to attend interventions and assessments in the area of Bergen, Norway

          -  Has given informed consent

        Exclusion Criteria:

          -  Hearing impairment that cannot be mended by hearing aids

          -  Conditions that hinder MRI scans, such as claustrophobia or metal objects in body
             (e.g. pacemakers)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Versartis Trial in Pre-pubertal Japanese Children With Growth Hormone Deficiency (GHD) to Assess Long-Acting Growth Hormone (Somavaratan, VRS-317)

Eligibility criteria:
Inclusion Criteria:

          -  Chronological Age ≥ 3.0 years and ≤ 9.0 years (girls) or ≤ 10.0 years (boys)

          -  Pre-pubertal status

          -  Diagnosis of GHD as documented by two or more GH stimulation test results

          -  Height SD score ≤ -2.0 at screening

          -  Weight for Stature ≥ 10th percentile

          -  IGF-I SD score ≤ -1.0 at screening

          -  Delayed bone age

        Exclusion Criteria:

          -  Prior treatment with any growth promoting agent

          -  History of, or current, significant disease

          -  Chromosomal aneuploidy, significant gene mutations (other than those that cause GHD)
             or confirmed diagnosis of a named syndrome

          -  Birth weight and/or birth length less than 5th percentile for gestational age

          -  A diagnosis of Attention Deficit Hyperactivity Disorder

          -  Daily use of anti-inflammatory doses of glucocorticoid

          -  Prior history of leukemia, lymphoma, sarcoma or cancer

          -  Ocular findings suggestive of increased intracranial pressure and/or retinopathy at
             screening

          -  Significant spinal abnormalities including scoliosis, kyphosis and spina bifida
             variants

          -  Significant abnormality in screening laboratory studies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Cough Monitoring Study

Eligibility criteria:
Inclusion Criteria:

        Arm 1: healthy volunteers:

          1. Male and female volunteers 18 years of age and older

          2. No history of chronic or acute cough and throat clearing

          3. Ability to read a 5th grade script written in English for approximately 20 minutes

        Arm 2: patients:

          1. Male and female volunteers 18 years of age and older

          2. Cough as chief complaint

          3. Referred to the GI clinic to evaluate if reflux is the cause of their chief complaint

          4. pH testing for standard of care purposes

        Exclusion Criteria:

          -  Subjects who are not able to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Prevention of Cystitis.

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
             inclusion criteria may choose to answer the questionnaire in the waiting room of
             general practitioners selected by lot.)

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Nociceptors, Neurotrophic Factors and Cytokine Expression in Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  subjects who completed upper GI endoscopy and questionnaires about GERD symptoms

        Exclusion Criteria:

          -  a history of gastrointestinal surgery

          -  Barrett's esophagus

          -  esophageal motility disorder

          -  duodenal ulcer

          -  benign gastric ulcer

          -  gastroduodenal cancer

          -  if he or she had any history of systemic disease requiring chronic medication (except
             for hypertension and diabetes mellitus).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction