Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly

Eligibility criteria:
Inclusion Criteria:

          -  Age 60-85 years' old

          -  Both male and female patients

          -  ASA I-II

          -  Body mass index (BMI) ≤ 30 kg/m2

          -  Elective surgery under general anaesthesia with the use of laryngeal mask airway (LMA)
             / LMA Proseal / LMA Supreme

          -  Type of surgery: Urogynecological, General Surgery, Orthopedics, Eye, Vascular,
             Plastic

          -  Surgery/anaesthesia lasting for 0.5-3 hours

        Exclusion Criteria:

          -  Patients with difficulty in swallowing, preexisting neuromuscular or central nervous
             system disorder

          -  Patients undergoing intra abdominal, thoracic, face, nasal or throat surgery

          -  Known condition interfering with gastric emptying

          -  Patients with cognitive or hearing impairment and inability to provide informed
             consent

          -  ASA III-IV patients

          -  Use of muscle relaxant during the course of general anesthesia

          -  Contraindication or previous adverse response to any of the study drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Observational Study of Patients With Duchenne Muscular Dystrophy Theoretically Treatable With Exon 53 Skipping

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Duchenne muscular dystrophy confirmed by at least genetic testing,
             theoretically treatable by exon 53 skipping.

          -  Age between ≥ 12 and <20 years old.

          -  Non ambulant patients (i;e; inability to walk more than 10 meters without any of
             assistance).

          -  Patients covered by a national health insurance scheme.

          -  Signed informed consent.

        Exclusion Criteria:

          -  Patient incapable of sitting upright in a wheelchair for at least one hour.

          -  Patients with severe intellectual impairment preventing them from fully understanding
             the exercises to be performed.

          -  Recent (less than 6 months ago) upper limb surgery or trauma This criteria is however
             no definitive. Patients who have undergone upper limb surgery or trauma may
             nonetheless be enrolled once the 6 month period is over.

          -  Known immune deficiency.

          -  Contraindications to NMR exams
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Persistent Facial Erythema

Eligibility criteria:
Inclusion Criteria:

          -  Male or female, who is at least 18 years of age or older at screening visit.

          -  Presence of chronic persistent vascular facial erythema for ≥ 3 months by history.

          -  A Clinician's Erythema Assessment (CEA) score of ≥3 at Screening and at Pre-dose (T0)
             on Baseline/Day 1.

          -  A Patient Self Assessment (PSA) score of ≥3 at Screening and at Pre-dose (T0) on
             Baseline/Day 1.

        Exclusion Criteria:

          -  More than 2 facial inflammatory lesions (papules, pustules, and nodules).

          -  Presence of areas of significant scaling or crusting on the face.

          -  Presence of psoriatic lesions on the face.

          -  Presence of any other dermatological condition of the face that, in the opinion of the
             Investigator, may significantly interfere with the interpretation of the clinical
             trial results.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Antiresorptive Effects of a 6-m Treatment Course With Ibandronate Plus Supplementation of Vitamine D and Calcium in Central America

Eligibility criteria:
Inclusion Criteria:

          -  Women with a diagnosis of osteoporosis of at-Risk

          -  Have a medical indication to receive Ibandronate+Vitamine D+Calcium

        Exclusion Criteria:

          -  Osteoporosis due to secondary causes
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
             at least three months

          -  Referred normal menses .Use of the same brand of sanitary protection wear for the
             whole of the period.

          -  BMI between 18 and 30

        Exclusion Criteria:

          -  Abnormal Bleeding Score

          -  Positive gynecological history of fibroids, polyps or malignancy

          -  Treatment with anti-coagulants, antifibrinolytics, non steroidal anti-inflammatory
             agents

          -  Use of oral contraceptives in past three months

          -  Use of intrauterine devices (IUDs) in past three months .Hgb levels <12 g/dl and
             Ferritin <25 ng/ml.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Absorbable Sutures , Non Absorbable Sutures or Biologic Fibrin Glue for Protesic Mesh Fixing in Lichtenstein Technique for Primitive Groin Hernia Repair: a Randomized Prospective Multicentric Trial

Eligibility criteria:
Inclusion Criteria:

          -  primitive inguinal hernia

          -  age > 18 years old

          -  compliancy to the study

        Exclusion Criteria:

          -  reccurent inguinal hernia

          -  age < 18 years old

          -  refusal of the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Diagnostic Accuracy of Optimized Diffusion-Weighted Imaging for Detecting Anterior Ischemic Optic Neuropathy

Eligibility criteria:
Inclusion Criteria:

          -  Patient over 18 years old

          -  Patient with suspected NOIA, evoked after clinical examination by a specialized
             ophthalmologist

          -  For which a brain and visual MRI is planned

          -  Express consent to participate in the study

          -  Affiliate or beneficiary of a Social Security scheme

        Exclusion Criteria:

          -  Contraindication to MRI (electrical device, metallic foreign body, claustrophobia)

          -  Patient benefiting from a legal protection measure

          -  Pregnant or breastfeeding woman
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Effect of Pantoprazole 40mg Daily vs Placebo on Power Spectral Analysis of the Sleep EEG of Patients With GERD.

Eligibility criteria:
Inclusion Criteria:

          -  18 to 80 yrs of age

          -  2 to 3 episodes of GERD/week

          -  erosive esophagitis or abnormal 24 hr pH

          -  able to read and understand, complete questionnaires

        Exclusion Criteria:

          -  barrett's esophagus or peptic stricture on endoscopy

          -  normal EGD and normal 24 hour pH

          -  previous upper GI surgery

          -  comorbidity (cardiovascular, respiratory, renal, hepatic)

          -  use of narcotics or pain medication on regular basis

          -  insomnia, shift work sleep disorder, sleep apnea, restless leg syndrome

          -  diabetes, scleroderma or neuromuscular disorders
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with ACTH independent endogenous Cushing's Syndrome

          -  Available adrenal imaging prior to being treated with Korlym®

          -  Treated with Korlym® and followed for at least 3 months (follow-up data should be
             available)

        Exclusion Criteria:

          -  Diagnosed with adrenocortical carcinoma

          -  Participant in any clinical trial(s) during the observational period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of Anti-gravity Treadmill Training on Knee Osteoarthritis in Geriatric Population.

Eligibility criteria:
Inclusion Criteria:

          -  Male and female

          -  Age group 50-75 years

          -  Knee osteoarthritis GI, GII and G III (Kellgren & Lawrence system).

        Exclusion Criteria:

          -  Traumatic arthritis

          -  Unstable cardiovascular state

          -  Neuro-muscular disorders involving the lower extremity

          -  History of surgery of lower limb
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment