Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Multi-omics Study of Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed adenomyosis and/or endometriosis

          -  Signed an approved informed consents

          -  Feasible for biopsy

        Exclusion Criteria:

          -  Not meeting all of the inclusion criteria
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Socialization of Adult Men With Congenital Hemophilia A or B

Eligibility criteria:
Eligibility criteria for person with congenital bleeding disorder(PWCBD, men with
        congenital hemophilia):

          -  Known diagnosis of congenital hemophilia A or B with or without inhibitor (defined by
             a plasma factor VIII or factor IX level below lower limits of normal and medical
             history consistent with diagnosis).

          -  Male age 21 years or older

          -  Willing to indicate if they have a spouse or significant other.

          -  Able to read, write and participate in interview on site.

        Exclusion Criteria for PWCBD:

          -  Other bleeding disorder besides congenital hemophilia A or B

        Eligibility criteria for spouses/significant other (SSO) participants in the study:

          -  A person in a relationship for a minimum of 9 months with the PWCBD participating in
             the study.

          -  PWCBD partner must be participating in the study.

          -  Willing to participate in questionnaire and interview on site.

        Exclusion criteria for SSO:

        - Biologically related to PWCBD participant (that is, not a parent, sibling, child or other
        biologically-related caregiver).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss

Eligibility criteria:
Inclusion Criteria:

          -  Patients with unexplained RPL.

          -  Patients with abnormal immunological profile, including ANA, RF, anti-DNA,
             antilymphocyte, anticardiolipin, antithyroid and lupus anticoagulant antibodies that
             have no other clinical manifestation.

          -  Women with three or more pregnancy losses (before 24 weeks of gestation) who referred
             to the RPL clinic in Soroka hospital.

          -  An age above 25 years.

          -  The women agreed to participate in the study and signed on a consent form.

          -  women with index pregnancy.

        Exclusion Criteria:

          -  Presence of any genetic impairment, Mullerian anomaly, endocrine or metabolic
             disorders, or a luteal-phase defect (as determined by a timed endometrial biopsy).

          -  Diabetes mellitus diagnosed by symptoms of diabetes plus random glucose concentration≥
             200mg/dL or fasting plasma glucose≥ 126mg/dL or hemoglobin A1C≥5.8% or 2-h plasma
             glucose≥ 200mg/dL during an oral glucose tolerance test.

          -  Previously untreated tuberculosis, as determined by an abnormal chest film in the
             previous year or a positive tuberculin skin test.

          -  Prednisone therapy during pregnancy for other reasons.

          -  Sensitivity to prednisone.
Female
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy persons aged ≥ 18, and able to give informed consent

          -  Patient is admitted to hospital

          -  Primary reason for hospital admission is clinical suspicion of a new episode of ARI

          -  Onset of the following symptoms within the last 7 days: i. Sudden onset of
             self-reported fever OR temperature of ≥ 38°C at presentation AND ii. At least one
             respiratory symptom (cough, sore throat, runny or congested nose, dyspnoea) AND iii.
             At least one systemic symptom (headache, muscle ache, sweats or chills or tiredness).

        Exclusion Criteria:

          -  Patient lacks capacity to provide informed consent

          -  Patient has been transferred from another hospital

          -  Patient has been previously enrolled in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Mexican Initiative of Patients With Osteoarthritis and Rheumatoid Arthritis (IMPACTAR)

Eligibility criteria:
Inclusion Criteria:

          -  Patients > 18 years with diagnosis of OA or RA according to the criteria of the
             American College of Rheumatology (ACR).

        Exclusion Criteria:

          -  Patients with precedents of fractures; carrying patients of chronic diseases who limit
             them in the functional capacity.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Effect of Oral Zinc Supplementation as an Adjuvant to Topical Corticosteroid in Oral Lichen Planus Patients

Eligibility criteria:
Inclusion Criteria:

          1. Clinically and histopathologically proven cases of erosive and atrophic OLP.

          2. Patients who are willing to participate in the study.

        Exclusion Criteria:

          1. Patients with reticular form of OLP and OLP with muco-cutaneous involvement.

          2. Patients consuming drugs for the treatment of OLP in the past 6 months.

          3. Suspected lichenoid reaction associated with drugs and restorations.

          4. Patients whose histopathological findings indicate moderate to severe dysplasia.

          5. Patients with acquired and congenital immuno-deficiency disorders like AIDS,
             chemotherapy, addiction to injectable opioids like hemophilia and blood dialysis.
             These patients are excluded because of difficulty in their biopsy procedure, control
             of infection, possible interaction with clinical findings of OLP, and their potential
             doubtful cooperation.

          6. Patients with systemic diseases involving the gastro-intestinal tract.

          7. Known cases of Acrodermatitis enteropathica where difficulty in zinc absorption
             persists.

          8. Presence of factors that can alter the absorption of zinc like consumption of calcium
             tablets, iron supplements and high protein diet.

          9. Pregnancy and lactation phase

         10. Alcoholic patients, since alcoholism results in intracellular zinc deficiency.

         11. Recorded allergy to zinc and/or corticosteroids.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
Inclusion Criteria:

          -  Ages 2-17 years old with a confirmed diagnosis of DMD. Has an appointment in MDA
             clinic at the Ann & Robert H. Lurie Children's Hospital of Chicago.

        Exclusion Criteria:

          -  Is less than two years old and does not have a confirmed diagnosis of DMD.
Male

Subject must be at least 2 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women

          -  Regular menstrual cycles (23 -35 days cycle length)

          -  No systemic or intrauterine steroid hormone use

        Exclusion Criteria:

          -  Psychiatric disorder (DSM IV Axis I or WHO ICD-10 diagnostic classification).

          -  Prior or present neurological or other severe medical condition including substance
             abuse.

          -  No drug intake suspected to influence results

          -  Conditions that may increase risk by participating in the study program including
             ovarian cysts

          -  Pregnancy during the last year

          -  Delivery during the last 2 years

          -  Presently wishing to obtain pregnancy

          -  Breast feeding

          -  Not fluent in Danish or severe visual or hearing impairments

          -  Earlier or present learning disabilities

          -  Claustrophobia (due to MRI scans)

          -  Metal implants (excludes MRI)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial

Eligibility criteria:
Inclusion Criteria:

          1. Pregnant females >= 18 years of age

          2. Confirmed VWD, as defined by VWF:RCo < 0.50 IU/dL and previous history of bleeding

          3. Willingness to have blood drawn

          4. Willing to be randomized to one of two treatments at delivery and for 2 days
             postpartum.

          5. Willing to keep a diary for 3 weeks of postpartum bleeding by pictorial assessment
             chart (PBAC) and any blood products, transfusion, or medications taken.

          6. Willing to return at 21 days for final blood draw and review of diary.

        Exclusion Criteria:

          1. Any bleeding disorder other than VWD; or past thrombotic disease of other bleeding
             disorders.

          2. Previous thrombosis, cardiac disease, congestive failure, arrhythmia, hypertension,
             MI, or stroke.

          3. Platelet count < 100,000/ ul.

          4. Past allergic reaction to VWF or tranexamic acid.

          5. Surgery within the past 8 weeks.

          6. Inability to comply with study protocol requirements.

          7. Concomitant use of antiplatelet drugs, anticoagulants, aspirin or NSAIDs.

          8. Treatment with DDAVP, cryoprecipitate, whole blood, plasma or plasma derivatives
             containing substantial quantities of VWF within 5 days of study.

          9. History of renal disease.

         10. Inability to comply with study requirements.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of definite or possible ALS by the El Escorial Criteria

          -  No previously known gastrointestinal problems

        Exclusion Criteria:

          -  Patients or controls who have evidence of previous gastrointestinal disease

          -  Patients unable to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment