Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion

Eligibility criteria:
Inclusion Criteria:

          -  Request for elective abortion

          -  Ability to understand the consent form

          -  A pregnancy of 7 weeks gestation or less on Day 1

          -  Documented by endovaginal ultrasound

          -  Willingness to comply with visit schedules

        Exclusion Criteria:

          -  Haemoglobin less than 90 g/L

          -  Uncontrolled seizure disorder

          -  Active liver disease (aspartate aminotransferase >2x normal)

          -  Renal insufficiency (serum creatinine >120umol/L)

          -  A history of intolerance to methotrexate or misoprostol
Female
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Endoscopic Submucosal Dissection Versus Surgery in the Treatment of Early Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Clinically diagnosed as early gastric cancer

          -  Willing to undergo endoscopic submucosal dissection or surgery for the treatment of
             early gastric cancer

        Exclusion Criteria:

          -  Advanced stage gastric cancer

          -  Not willing to undergo endoscopic submucosal dissection or surgery for the treatment
             of early gastric cancer

          -  Not willing to participate in this study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Eligibility criteria:
Inclusion Criteria:

          -  patients with both unilateral adrenal incidentaloma and hypercortisolism

          -  definition of hypercortisolism

               -  overnight dexamethasone suppression test, serum cortisol>1.8ug/dL

               -  24hr urine cortisol > upper reference limit

        Exclusion Criteria:

          -  patients who took medication influencing cortisol secretion

          -  patients with definite clinical feature of cushing syndrome

               -  moon face

               -  abdominal striae

               -  skin or proximal muscle atrophy

          -  metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure,
             rheumatic disease, hematologic disease

          -  patients who took following medication

               -  insulin

               -  oral hypoglycemic agent

               -  thyroid hormone

               -  anti-hyperlipidemic drug

               -  sex hormone

          -  patients who taking steroid hormone or who took steroid hormone more than 2 weeks
             within 1 year

          -  psychiatric disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study

Eligibility criteria:
Inclusion Criteria:

          1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
             gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
             periods with heavy menstrual bleeding with a PBAC score greater than 100;
             menometrorrhagia is heavy vaginal bleeding occurring at irregular intervals.

          2. PBAC Score greater than 100 for 2 consecutive cycles

          3. Pelvic ultrasound that excludes pelvic pathology that can cause menorrhagia within 12
             months prior to study participation.

          4. Normal external genitalia examination within 6 months prior to study participation.

          5. Normal thyroid stimulating hormone (TSH) in the last 6 months prior to study
             participation.

          6. Negative urine or serum pregnancy test within 4 weeks prior to study participation.

        Exclusion Criteria:

          1. Presence of intra uterine device.

          2. Presence of a diagnosed bleeding disorder based on the standard work-up including
             complete blood count (CBC), prothrombin time, partial thromboplastin time, fibrinogen,
             von Willebrand panel and platelet function analysis (PFA-100) or platelet aggregation.

          3. Intake of medications with increased risk of bleeding

          4. Taking herbal products.

          5. Sexually active status.

          6. Body weight less than 40 kg.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Serum and Peritoneal CEA and CA 19-9 for Gastric Adenocarcinoma

Eligibility criteria:
Inclusion Criteria:

          -  Endoscopically proven gastric adenocarcinoma

          -  Standard gastrectomy and a D2 lymph node dissection;

          -  Desire to attend the study protocol

        Exclusion Criteria:

          -  Metastatic or overt peritoneal disseminated cancer

          -  Undesired reaction to attend the study protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: School-based Physical Activity Intervention for Obesity Among Adolescents With Intellectual Disability in Hong Kong

Eligibility criteria:
Inclusion Criteria:

          -  aged between 12 and 18 years

          -  overweight and obesity

          -  mild or moderate intellectual disability

        Exclusion Criteria:

          -  physical disability

          -  medical predispositions towards obesity (genetic syndrome or drug treatment)

          -  contraindications (e.g. asthma, heart disease)

          -  having participated in other exercise programs in the past 6 months.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Safety/Efficacy of Balicatib (AAE581) in Adults With Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          -  At least one knee with osteoarthritis with Kellgren-Lawrence grade 3

          -  Significant osteoarthritis pain in the knee

          -  Presence of at least one of the risk factors: obesity (BMI > 28), osteoarthritis at
             other sites, knee effusion, family history of total joint replacement

        Exclusion Criteria:

          -  Women with childbearing potential

          -  Secondary osteoarthritis

          -  Treatment with intra-articular or systemic steroids

          -  Inability to undergo MRI acquisition

        Other protocol defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Mechanism Research of Tinnitus Based on Electroencephalogram and Acoustic Therapy Intervention

Eligibility criteria:
Inclusion Criteria:

          1. 18-30 years old, male or female;

          2. PTA (0.5,1,2kHz) ≤25dB HL;

          3. Tinnitus is a major problem faced by patients (except healthy volunteers);

          4. tinnitus course > for 3 months;

          5. Healthy, no history of other ear diseases, no history of hearing impairment;

          6. There are no other medical, psychological or social problems that need urgent
             treatment, and no other problems that interfere with tinnitus-related treatment;

          7. Voluntary tinnitus treatment, and have enough time to cooperate with treatment.

        Exclusion Criteria:

          1. Pulsatile tinnitus;

          2. Acute tinnitus;

          3. Tinnitus is associated with severe hearing loss;

          4. Tinnitus accompanied by vertigo;

          5. Tinnitus accompanied by headache;

          6. Tinnitus is accompanied by somatic symptoms, such as neck pain and temporomandibular
             joint disorder;

          7. Post-traumatic tinnitus;

          8. Tinnitus is associated with serious psychiatric complications;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Patient with bleeding history sent to the Hemophilia Treatment Center in Dijon or
             Nantes University Hospital with abnormal bleeding score (>3 in men and >5 in women

          -  Patient who has provided a signed consent to participate at this study and for blood
             sampling

          -  Affiliation with French social security system

        Non-Inclusion Criteria:

          -  Minors will not be included in the study.

          -  On-going pregnancy and postpartum period (3 months after delivery)

          -  Substitutive treatment with coagulation factor concentrates or desmopressin
             administration within 10 days before sampling.

          -  Ongoing infectious or inflammatory disease that can modify VWF levels.

          -  Diagnosis of obvious hemostasis disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Effect of Genetic Association With Functional Dyspepsia and Mood Disorders

Eligibility criteria:
Inclusion Criteria:

          -  All subject

               -  Age 18-60

               -  Provision of written consent

        Additional to FD patient

          -  Symptoms fulfilling Rome III criteria of functional dyspepsia

          -  Negative upper endoscopy (oesophagogastroduodenoscopy or OGD) finding

        Exclusion Criteria:

          -  All subject

               -  History of cancer

               -  Diabetes mellitus

               -  History of gastric surgery

               -  Acid suppressants or medications that affect motility in past 4 weeks

               -  Organic disease as cause of dyspepsia (for subjects with dyspeptic symptom)

        Additional to healthy volunteer

        • Any gastrointestinal symptoms (including acid regurgitation, heartburn, epigastric pain,
        bloating sensation, constipation, abdominal pain, diarrhea) in the past 4 weeks

        Additional to FD patient

          -  Frequent (once or more per week) acid reflux or heartburn symptoms

          -  Helicobacter pylori (Hp) infection
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction