Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: The Effectiveness and Cost-effectiveness of Mental Wellness Youth Hub

Eligibility criteria:
Inclusion Criteria:

          -  For hub-user group (experimental group): 12 - 24 year- old hub users who receive
             community-based mental wellness youth hub services for young people.

          -  For non-hub user group (active control group): 12 -24 year- old youths who do not
             receive the community-based mental wellness youth hub services but other generic youth
             services in the community.

          -  For non-hub user group (passive control group): 12 -24 year- old community youth who
             do not receive any youth services in the community.

        Exclusion Criteria:

          -  Youths with known diagnosis of psychiatric disorders (including Depression,
             Generalized Anxiety Disorder, Panic Disorder, Phobia, Obsessive Compulsive Disorder,
             Bipolar Disorder, Eating Disorder, Personality Disorder, Post-Traumatic Stress
             Disorder and Psychotic Disorder)

          -  Youths who receive psychiatric medication (including antidepressants, antipsychotics
             and antiepileptic drugs)

          -  Youths who have limited comprehension due to epilepsy or mental retardation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 24 Years

Eligibility (NLI label): Contradiction