Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With Rosacea

Eligibility criteria:
Inclusion Criteria:

        -Moderate to severe persistent facial erythema associated with rosacea.

        Exclusion Criteria:

          -  Greater than 3 inflammatory lesions on the face

          -  Current treatment with monoamine oxidase (MAO) inhibitors

          -  Raynaud's syndrome, narrow angle glaucoma, orthostatic hypotension, scleroderma or
             Sjogren's syndrome.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Erythrocytapheresis Versus Phlebotomy as Maintenance Therapy in Hereditary Hemochromatosis (HH) Patients

Eligibility criteria:
Inclusion Criteria:

          -  homozygous for C282Y

          -  currently treated with phlebotomy as maintenance therapy for at least 6 month

          -  ferritin level between 30-50 micog/L

          -  age 18 years an older

          -  weight more than 50 kg

          -  signed informed consent

          -  willingness to fill out additional questionnaires at three points in time

        Exclusion Criteria:

          -  chelating therapy

          -  forced dietary regime

          -  aged below 18 years

          -  excessive overweight ( BMI more than 35)

          -  pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

        Main inclusion criteria:

          1. Familial or sporadic ALS

          2. Patient diagnosed with probable of definite ALS

          3. Patient treated with a stable dose of riluzole (100 mg/day) for at least 30 days prior
             to screening

        Exclusion Criteria:

        1. Patient who underwent tracheostomy and/or gastrostomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Identification of Risk Factors for Arrhythmia in Children and Adolescents With Hypertrophic Cardiomyopathy

Eligibility criteria:
-  Children and adolescents (less than or equal to 21 years) with HCM who had been
             evaluated in the Cardiology Branch, National Heart Lung and Blood Institute between
             1977 and 2002. HCM was diagnosed by echocardiographic demonstration of a hypertrophied
             non-dilated left ventricle (LV) in the absence of another cause of LV hypertrophy. All
             patients participated in protocols approved by the NHLBI Institutional Review Board,
             and provided informed written consent to participate. The patients participated in the
             following protocols: 98-H-0102, 77-H-0082, 99-H-0150, 01-H-0007, 96-H-0144, 94-H-0001,
             84-H-0232, 98-H-0100, and 99-H-0065.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Study to Evaluate Dietary Modification in Patients With Functional Dyspepsia.

Eligibility criteria:
Inclusion Criteria:

          -  Men and women 18 years and older

          -  Diagnosis of FD with either PDS or EPS as measured by Rome III Criteria

          -  Patients describing inadequate relief of dyspepsia symptoms

          -  Endoscopy performed in the last 3 years and negative for an organic cause for
             dyspeptic symptoms

          -  H pylori negative by non-invasive testing or biopsy. Patients with a history of
             successfully eradicated H pylori will be included if follow-up testing by stool
             antigen, urea breath testing, or biopsy is negative

          -  Celiac disease excluded by serologies or biopsy

        Exclusion Criteria:

          -  Patients with IBS predominant symptoms that are not well controlled

          -  Patients with a diagnosis of GERD who have uncontrolled heartburn

          -  History of esophagitis, ulcer disease, or other organic upper GI disease, including a
             diagnosis of celiac disease, gastroparesis, or vascular disorders of the upper GI
             tract

          -  History of surgery involving the esophagus, stomach, or duodenum

          -  Known lactose intolerance, unless symptoms persist on a lactose free diet

          -  Known fructose intolerance unless symptoms persist on a fructose free diet

          -  Patients undergoing active titration of any medications

          -  Pregnant or breastfeeding women

          -  Prisoners
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: REFRESH: Receptivity Enhancement by Follicular-phase Renewal After Endometrial ScratcHing

Eligibility criteria:
Inclusion Criteria:

          -  Fresh IVF/ICSI cycle

          -  Antagonist down-regulation

          -  Signed informed consent

        Exclusion Criteria:

          -  Other known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting
             the endometrial cavity, Asherman's syndrome, thrombophilia or endometrial
             tuberculosis)

          -  Oocyte donation acceptors

          -  Frozen egg transfers

          -  Embryos planned to undergo preimplantation genetic diagnosis (PGD)

          -  BMI >35 or <18

          -  Women already recruited for another trial on medically assisted procreation during the
             same cycle

          -  Women who have previously enrolled in the trial

          -  Those unable to comprehend the investigational nature of the proposed study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Intra-articular Injection in the Knee of Adipose Derived Stromal Cells and Platelet Rich Plasma for Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  patients age 50 or older who present with symptomatic primary osteoarthritis of the
             knee

          -  daily pain for the previous 3 months

          -  analgesics usage at least once a week

          -  less than 30 minutes of morning stiffness

          -  WOMAC score of ≤ 75 in the target knee

          -  Brandt Radiographic Grading Scale of Osteoarthritis grade 1 and 2

        Exclusion Criteria:

          -  evidence of secondary knee osteoarthritis

          -  severe osteoarthritis (Joint space width - JSW < 2 mm)

          -  prior intra articular injections within the previous one year prior to inclusion

          -  patients with clinically significant systemic disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Idiopathic Pulmonary Fibrosis Registry for Future Studies

Eligibility criteria:
Inclusion Criteria:

          -  any patient referred to the Interstitial Lund Disease clinic who is undergoing
             evaluation and or treatment for a new diagnosis of ILD. This can include patients
             referred for presumed pulmonary fibrosis/interstitial pneumonitis (IPF, UIP, NSIP),
             sarcoidosis, hypersensitivity pneumonitis, cryptogenic organising pneumonia,
             drug-induced, or other idiopathic ILDs.

        Exclusion Criteria:

          -  pregnancy

          -  inability to follow study requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair

Eligibility criteria:
Inclusion Criteria:

          -  Informed consent

          -  Age 18 years or older

          -  Diagnosis of reducible incisional hernias up to 200 cm²

          -  Medically fit for general anesthesia

          -  Comprehension and use of French language

          -  Installed in the geographical region without foreseeable move for two years

        Exclusion Criteria:

          -  Incarcerated hernia

          -  Ongoing chronic pain syndrome, other than hernia origin

          -  Coagulation disorders, prophylactic or therapeutic anticoagulation, unable to stop
             platelet antiaggregation therapy 10 days before surgery

          -  American Society of Anesthesiology Class 4 and 5 patients

          -  Emergency surgery, peritonitis, bowel obstruction, strangulation, perforation

          -  Mentally ill patients

          -  Presence of local or systemic infection

          -  Life expectancy < 2 years

          -  Any cognitive impairment (Psychiatric disorder, Alzheimer's disease etc.)

          -  Morbid obesity (BMI over 40)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Osteoporosis Disease Management Demonstration Project (0000-037)

Eligibility criteria:
Inclusion Criteria:

          -  Members of the Henry Ford Health System

        Exclusion Criteria:

          -  Individuals who are not members of the Henry Ford Health System
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Contradiction