Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Study Evaluating the Timing of Intrauterine Insemination in Relation to Positive Home Ovulation Prediction Kit

Eligibility criteria:
Inclusion Criteria:

          -  All couples consisting of male and female partner undergoing CC or letrozole cycle
             plus IUI at a single infertility center (Midwest Fertility Specialists)

          -  The female partner must be aged 21-39

          -  Infertile couples include those with a diagnosis(s) of unexplained infertility, mild
             male factor, ovulatory dysfunction, or anovulation

          -  Evidence of a normal uterus and at least unilateral tubal patency on saline infusion
             sonogram or hysterosalpingogram within the last 2 years

          -  Semen analysis for male partner must have minimal sperm concentration of 10 million
             per milliliter

        Exclusion Criteria:

          -  Recurrent miscarriages

          -  Nursing mothers

          -  Diagnoses of primary ovarian failure, diminishing ovarian reserve (as indicated by
             blood follicle stimulating hormone >10 milliInternationalUnits/mL and/or
             anti-mullerian hormone level <0.5), abnormal uterine bleeding of undetermined origin,
             ovarian cyst of undetermined origin, stage IV endometriosis, or sex-hormone dependent
             tumors

          -  Documented bilateral tubal obstruction or other uncorrected uterine anomalies (e.g.
             uterine septum)

          -  Previous gonadotropin use and/or previous treatment with in vitro fertilization

          -  Abnormal semen analysis (sperm concentration less than 10 million per mL) or
             ejaculatory dysfunction in male partner

          -  Other uncorrected medical condition in female partner that would be a contraindication
             to attempting elective ovulation induction (e.g., uncontrolled diabetes, intracranial
             lesion, thyroid or adrenal disease)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction