Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Analysis of a Virtual Reality Task in Patients With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of DMD.

        Exclusion Criteria:

          -  presence disorders in cognitive function that would prevent comprehension of the
             experimental instruction.
Male
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 34 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of CKD-333 Tablet

Eligibility criteria:
Inclusion Criteria:

          1. Patients with a mean sitting systolic blood pressure (MSSBP) ≥ 140 mmHg measured on
             selected arms after run-in period

          2. Lipid levels measured after run-in period were:

               -  Group 1: hypertension + dyslipidemia only → fasting LDL-C ≥ 160 mg / dL

               -  Group 2: hypertension + dyslipidemia + cardiovascular risk factor more than 1 →
                  fasting LDL-C ≥ 130mg / dL

               -  Group 3: hypertension + dyslipidemia + coronary artery disease or equivalent or
                  10-year risk assessed by Framingham Point Score greater than 20% → fasting LDL-C
                  ≥ 100 mg / dL

        Exclusion Criteria:

          1. Patients whose blood pressures measured at Visit 2 were:

               -  Patients with MSSBP ≥ 180 mmHg and / or MSDBP ≥ 110 mmHg

          2. Patients who had lipid levels measured at Visit 2

               -  Patients with fasting LDL-C <100 mg / dL or fasting LDL-C> 250 mg / dL and / or
                  TG ≥ 500 mg / dL
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Ages 30-60

          -  Knee pain

          -  Radiographically confirmed knee osteoarthritis

        Exclusion Criteria:

          -  Medical conditions contraindicating moderate aerobic exercise as determined through
             prescreening questions, ie: heart condition, asthma, history of stroke.

          -  Inability to exercise via treadmill or exercise cycle

          -  Contraindication to radiography

          -  Pregnancy

          -  History of recent joint injection (steroid, synvisc, etc.) within 6 weeks of study

          -  History of previous joint arthroplasty

          -  History of inflammatory joint disease

          -  Inability to sign informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Hiatal Interrogation in Sleeve Gastrectomy

Eligibility criteria:
Inclusion Criteria:

          1. Any patient deemed a candidate for Sleeve Gastrectomy.

          2. Age 18 years or older.

          3. Body Mass Index equal or greater to 40 without comorbidities OR Body Mass Index equal
             or greater than 35 with at least one obesity co-morbidity.

        Exclusion Criteria:

          1. The presence of one or more of the following will be reason for exclusion:

               1. Daily Proton Pump Inhibitor or H2 blocker use for typical GERD symptoms during
                  Screening day to Surgery day

               2. GERD Health Related Quality of Life (HRQL) questionnaire score greater than or
                  equal to 15.

          2. Hiatal hernia greater than 2cm by either preoperative endoscopy or Upper
             gastrointestinal (UGI) within one year of evaluation for bariatric surgery.

          3. The Los Angeles classification of the severity of reflux esophagitis: C,D

          4. Barrett's esophagus

          5. Dysphagia with poor esophageal function measured by motility testing.

          6. Does not meet National Institute of Health's weight loss surgery criteria.

          7. Inability to commit to no pregnancy for 18 months post operatively.

          8. Gastroparesis as defined by 4 hour nuclear emptying study.

          9. Previous bariatric surgery.

         10. Eosinophilia esophagitis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

        - Osteoarthritis of the knee requiring the therapy with non-steroidal anti-inflammatory
        drugs (NSAIDs)

        Exclusion Criteria:

        none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Ghrelin Levels in Children With Poor Growth

Eligibility criteria:
Inclusion Criteria:

          -  To be included in the short stature group, subjects must have had short stature,
             defined height less than -2 SD for gender and age or an abnormal growth velocity for
             gender and age).

          -  To be included in the failure-to-thrive group, subjects must have had poor weight
             gain, defined as weight less than -2 SD for gender and age or an abnormal weight
             velocity for gender and age.

          -  Patients in both groups will be evaluated for the presence of chronic gastrointestinal
             symptoms, defined as symptoms of gastrointestinal disease for greater than 6 weeks or
             recurrent symptoms. Patients who were affected in both weight and height will be
             stratified by which measurement was more severely affected, with poor weight gain
             being the primary problem in the "failure-to-thrive" grouping (Group 2) and "poor
             linear growth" being the primary problem in the short stature group (Group 1).

          -  Patients who have had chronic gastrointestinal symptoms, defined as symptoms of
             gastrointestinal disease for greater than 6 weeks or recurrent symptoms, but normal
             stature and growth, will be analyzed separately (Group 3).

        Exclusion Criteria:

          -  Must not have a known diagnosis as an etiology for growth failure or GI symptoms prior
             to presentation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Efficacy and Safety of IL-11 in DDAVP Unresponsive

Eligibility criteria:
Inclusion Criteria:

          -  Males or females >= 18 years of age.

          -  A diagnosis of hemophilia A, moderate (FVIII:C 0.01-0.04 U/ml) or mild (FVIII:C >=
             0.05 U/ml); or a diagnosis of VWD, defined by a low VWF:RCo and past bleeding history.

          -  For those with VWD, an inability to use DDAVP due to i) unresponsiveness defined as
             VWF:RCo or FVIII:C level lower than 50 IU/dl or less than a 3-fold increase after 0.3
             microgram/kg DDAVP; ii) allergic reactions or seizures; or iii) a contraindication to
             DDAVP.

          -  Willingness to have blood drawn.

          -  Willingness to sign informed consent.

        Exclusion Criteria:

          -  Presence of other bleeding disorders, acquired Von Willebrand disease, primary
             thrombocytopenia.

          -  Use of immunomodulatory or experimental drugs, or diuretics.

          -  Pregnant or lactating women.

          -  Previous cardiac disease, congestive failure, arrhythmia (e.g. atrial fibrillation,
             atrial flutter), hypertension, MI, stroke, or thrombosis.

          -  Past allergic reaction to Neumega.

          -  Surgery within the past 8 weeks.

          -  Inability to comply with study protocol requirements.

          -  Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin or NSAIDs.

          -  Treatment with DDAVP, cryoprecipitate, whole blood, plasma and plasma derivatives
             containing substantial quantities of FVIII and/or VWF within five days of study.

          -  Baseline safety and/or hematology lab values outside the normal limits and/or an EKG
             indicating an arrhythmia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Biorepository

Eligibility criteria:
Inclusion Criteria:

          -  The participant is a patient at TUKHS or has agreed to participate in a study approved
             by the KUMC Human Research Protection Program (HRPP).

          -  The participant has a diagnosis of COVID-19 confirmed by COVID-19 PCR.

          -  Patient is 18 years of age or older.

        Exclusion Criteria:

          -  Participant declines to participate (living patients only)

          -  Participant or healthcare surrogate is unable to provide informed consent (living
             patients only)
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Erythema migrans

          -  Over the age of 18

          -  Signing an concent form after information in writing

        Exclusion Criteria:

          -  Allergic to any of the three drugs in the study

          -  Under the age of 18

          -  Pregnancy

          -  Dementia or known drug abuse

          -  Antibiotic treatment last 14 days

          -  Concommitant Chemotherapy or immunomodulating therapy

          -  Concommitant use of medicine with potential interaction (defined in protocol)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Teriparatide (PTH) and Bone Strength in Postmenopausal Women

Eligibility criteria:
Inclusion Criteria:

          -  History of fragility fracture OR

          -  High risk for fractures OR

          -  Very low BMD (T-score ≤ -2.5) OR

          -  Failed or intolerant to bisphosphonates

          -  Baseline serum levels of calcium, urate, ALP, PTH, creatinine and 25-hydroxyvitamin D
             [25(OH)D] must be within acceptable normal limits

        Exclusion Criteria:

          -  History of skeletal irradiation

          -  Those at increased risk for osteosarcoma

          -  Diagnosis of Paget's disease

          -  History of primary hyperparathyroidism

          -  Significant renal impairment

          -  Vitamin D deficiency

          -  On steroids or have other causes of secondary osteoporosis
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment