Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Primary osteoarthritis of the knee, verified radiographically

          -  Moderate flare of pain in the knee after washout of stable therapy

          -  If female, non-pregnant

          -  Ability to swallow moderately-sized tablets

        Exclusion Criteria:

          -  Secondary osteoarthritis of the knee

          -  Major knee surgery at any time, or minor knee surgery in previous year

          -  Severe uncontrolled heart, liver or kidney disease

          -  Ulcer or bleeding from the stomach

          -  Corticosteroid use

          -  Fibromyalgia

          -  Skin disorder of the knee
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Rational Approach to a Unilateral Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          1. Patients with recurrent pleural effusion of unknown origin after a first pleural tap
             according to BTS guidelines.

          2. Indication for thoracoscopy according to BTS guidelines.

          3. Patients accept further investigation according to Danish and BTS guidelines.

          4. Have received oral and written consent and agreed.

          5. At the time of inclusion, above 18 years of age.

        Exclusion Criteria:

          1. Female patients: pregnancy or breastfeeding.

          2. Lack of language comprehension.

          3. Legally incompetent patients.

          4. Life expectancy less than 3 month.

          5. Contraindications to pleural tissue sampling.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Mesenchymal Stem Cells Enhanced With PRP Versus PRP In OA Knee

Eligibility criteria:
Inclusion Criteria:

          1. Grade 1 or Grade 2 Osteoarthritis knee as per Ahlbacks radiographic staging

          2. Patients willing to give consent

        Exclusion Criteria:

          1. Osteoarthritis secondary to joint inflammatory diseases (eg- rheumatoid arthritis,
             ankylosing spondylitis etc)

          2. Patients with other diseases, affecting the knee joint like crystal arthropathy,
             symptomatic chondrocalcinosis, acute synovitis, excessive joint effusion(>100ml),
             cystic disease around the knee joint(eg-popliteal cyst)

          3. Advanced stage of osteoarthritis

          4. Bone marrow suppression

          5. Co morbidities like pregnancy, cancer, immunosuppression,

          6. Osteoarthritis secondary to trauma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Intra-venous Zoledronic Acid Once Yearly

Eligibility criteria:
Inclusion Criteria:

          -  Patient is an ambulatory female 45 years of age or older

          -  Postmenopausal women with diagnosis of osteoporosis

          -  Prescription of zoledronic acid or any OBP as per the current Canadian monograph

          -  Must provide informed consent

        Exclusion Criteria:

          -  Any prior use of iv bisphosphonates within the last 2 years

          -  Known secondary osteoporosis of any aetiology (hypogonadism in premenopausal women or
             premature menopause, malabsorption, chronic liver disease, inflammatory bowel disease)

          -  Metabolic bone diseases such as primary or secondary hyperparathyroidism,
             hypoparathyroidism, Paget's disease of bone, Fibrous dysplasia..

          -  Non-corrected hypocalcaemia at the time of zoledronic acid infusion

          -  Creatinine clearance < or = 30 ml/min

          -  Unwillingness or inability to comply with the study requirements

          -  Concurrent participation in a clinical trial of an investigational drug, or within the
             last 30 days

        Other protocol-defined inclusion/exclusion criteria may apply.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation

Eligibility criteria:
Inclusion Criteria:

          -  bilaterally intact tympanic membranes

          -  flyer or diver with middle-ear symptoms

          -  flyer or diver without middle-ear symptoms (controls)

          -  generally good health

          -  no recent history of non-activity related otitis media

        Exclusion Criteria:

          -  existing middle-ear disease

          -  allergic rhinitis symptoms or "cold" on day of testing

          -  syndrome predisposing to otitis media

          -  history of ossicular reconstruction
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          1. Patients with a symptomatic MPE*

          2. Predicted survival of more than 6 months

          3. Eastern Cooperative Oncology Group (ECOG) score = Peformance status defined as a
             patient's level of functioning in terms of their ability to care for themselves, daily
             activity, and physical ability (walking, working, etc. ECOG 0-1 (or ECOG greater than
             or equal to 2 if it is felt that removal of pleural fluid would improve their status
             to 0 or 1).

               -  MPE is defined as histologically/cytologically proven pleural malignancy or an
                  otherwise unexplained pleural effusion in the context of clinically proven cancer
                  elsewhere.

        Exclusion Criteria:

          1. Age <18yrs;

          2. Unfit to undergo a surgical procedure (American Society of Anaesthesiologists Score
             >/=4); 3. Pleural infection;

        4. Chylothorax; 5. Pregnancy or lactation; 6. Uncorrectable bleeding diathesis; 7. Previous
        ipsilateral lobectomy/pneumonectomy; 8. Inability to consent or comply with protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Therapy in Amyotrophic Lateral Sclerosis (TAME)

Eligibility criteria:
Inclusion Criteria:

          1. Age 18-85

          2. Male or Female

          3. Clinically definite, probable, probable lab-supported, or possible ALS by El Escorial
             criteria

          4. ALSFRS-R > 25

          5. Must be willing to undergo longitudinal blood draws for biomarker analysis

          6. Must have a caregiver

          7. Availability and willingness to complete the study

          8. Capable of providing informed consent and complying with trial procedures

          9. If patients are taking riluzole and/or Radicava, they must be a on a stable dose for
             at least thirty days prior to the baseline.

        Exclusion Criteria:

          1. Patients with FVC ≤ 60%

          2. History of liver disease

          3. Severe renal failure

          4. History of intolerance to memantine

          5. Onset of weakness for greater than 3 years

          6. Any other co-morbid condition which would make completion of the trial unlikely

          7. If female, pregnant or breast-feeding; or, if of childbearing age, an unwillingness to
             use birth control.

          8. Taking any trial medications. Non-trial medications are not cause for exclusion.

          9. Unwillingness to provide consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Spinal Manipulation and Spinal Mobilization Effects in Participants With and Without Back Pain

Eligibility criteria:
Inclusion Criteria:

          -  presenting or not a history of chronic nonspecific back pain

        Exclusion Criteria:

          -  History of back trauma or surgery

          -  Severe osteoarthritis

          -  Inflammatory arthritis

          -  Vascular conditions

          -  Contraindication to the use of spinal manipulation or spinal mobilization

          -  Pregnancy

          -  Scoliosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction