Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 50 years

          -  ACR criteria for Giant cell arteritis (HUNDER 1990)

          -  Positive Temporal artery biopsy

          -  Plus standard inclusion criteria for Humira protocols

        Exclusion Criteria:

          -  Prednisone treatment for a different disease at a dose >15 mg/day

          -  Corticoid treatment for GCA more than 10 days

          -  GCA treatment with prednisone > 1 mg/kg whatever period of time

          -  GCA treatment with an anti-TNF, MTX, cyclosporine, cyclophosphamide, dapsone or
             steroid bolus

          -  Recent, permanent or transient visual loss due to GCA and the presence of any specific
             visual abnormality (diplopia, hallucination)

          -  Plus standard exclusion criteria for Humira protocols
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of Medicines Use Review in Slovenia

Eligibility criteria:
Inclusion Criteria:

          -  at least one prescription medicine for a chronic condition for at least six months

          -  deemed to be suitable for MUR by a pharmacist, certified to provide the MUR service;

          -  ability to communicate in Slovenian; The inclusion of patients was performed in
             accordance with the SOP MUR, to reflect how patients are generally offered MUR service
             in Slovenia.

        Exclusion Criteria:

          -  urgent need of MUR (the service delay due to randomization would risk their health);

          -  referred for MUR by a healthcare professional (general practitioner, nurse, etc.);

          -  the patient's carer, rather than the patient themselves, was able to attend the
             interviews and receive MUR;

          -  previously received MUR or an advanced medication review;

          -  difficulties understanding, communicating or other issues (vision, hearing) that might
             affect study outcomes.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: The Factors Associated With the Recurrence in Patients With Cushing Disease

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosed Cushing's disease

        Exclusion Criteria:

          -  Already received treatment in other hospital

          -  Ectopic Cushing's syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Antecedents of Bronchopulmonary Dysplasia

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

Eligibility criteria:
Inclusion Criteria:

          -  Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written
             informed consent

        Exclusion Criteria:

          -  • hypothyroidism of other origin

               -  pregnancy and lactation

               -  oral contraception

               -  glucocorticoid therapy during the last 2 months

               -  History of malignancy or chronic infections (Hepatitis, HIV)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: The Clinical Study of Sex Chromosome Variants

Eligibility criteria:
-  INCLUSION CRITERIA:

               1. Patients previously identified through outside research or diagnostic labs as
                  having sex-chromosome variants causing deletion/duplication of sex-linked genes
                  or entire sex chromosomes, male and female.

               2. In the event that a patient with a sex-chromosome variant self-refers to the
                  protocol, medical records will be reviewed by a committee to include Dr. David
                  Page, Dr. Maximilian Muenke, and others to decide whether the patient is
                  appropriate for enrollment in the protocol.

               3. Willing family members of subjects enrolled may be enrolled as control subjects.

        EXCLUSION CRITERIA:

          1. Anyone unwilling to provide informed consent or assent.

          2. We reserve the right to exclude patients with medical conditions that would place a
             potential participant at high risk of complications if managed at the NIH clinical
             center (ex. dialysis dependency, unstable cardiac conditions, unstable severe
             depression/suicidality).

          3. We reserve the right to exclude cases that are clearly not related to Ychromosome
             variants, infertility or our direct research interests (e.g. infertility with clearly
             non-genetic etiology). This almost never happens, and we would attempt to make
             referrals to a more appropriate investigator.

        It is our intention to try to remove as many economic, cultural, geographic, racial, and
        gender barriers as we reasonably can to promote a diverse participation of infertility
        cases for research purposes.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  American Indian ethnicity

          -  Membership in the White Mountain Apache community. (Although the investigators
             anticipate the vast majority of participants will be White Mountain Apache tribal
             members, study participation is open to all American Indian individuals who live on
             the Fort Apache Indian Reservation or on/near the border).

          -  Participants ages 11+ must have parent/legal guardian consent

          -  Adult participants must sign written informed consent

        Exclusion Criteria:

          -  Inability to participate in full intervention or evaluation (e.g., planned move,
             residential treatment, etc.)

          -  Unwilling to be randomized
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 11 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage

Eligibility criteria:
Inclusion Criteria:

          -  Singleton Pregnancy.

          -  Age20-35years.

          -  Gestational age between6 to 8weeks.

          -  Threatened miscarriage is diagnosed by vaginal bleeding, closed cervix and positive
             fetal life.

          -  Patients who are sure of their dates (three regular menstrual cycles before conception
             without the use of hormonal contraception.

        Exclusion Criteria:

        Patients with recurrent miscarriage or pregnancy of unknown location (PUL).

          -  Patients had ovulation induction medications or on progesterone treatment.

          -  Patients with past medical history of diabetes mellitus or chronic hypertension.

          -  Patients who are unsure of the last menstrual period date or with irregular menstrual
             cycle.

          -  Pregnancy associated with presence of ovarian cyst.

          -  Molar pregnancy.

          -  Those who had a history of maternal disease which would cause an increase in
             CA-125level. These diseases include chronic pelvic infection, endometriosis, myoma
             uteri, endometrioma and lung, kidney and hepatic diseases.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Fragile X Syndrome, who are at least moderately ill based on a Clinical
             Global Impression Severity score of at least 4 and have qualifying scores on the ABC-C
             and IQ test at Visit 1

        Exclusion Criteria:

          -  Advanced, severe or unstable disease that may interfere with the study outcome
             evaluations

          -  Cancer within the past 5 years, other than localized skin cancer

          -  Current treatment with more than two psychoactive medications, excluding
             anti-epileptics

          -  History of severe self-injurious behavior

          -  Weigh less than 32 kg

          -  Females who are sexually active

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Diagnostic Accuracy of FDG PET/CT of Cranial Arteries in GCA

Eligibility criteria:
Inclusion Criteria:

        Cases:

          -  1) age ≥50 years, 2) CRP>15mg/l or ESR>40mm/h, 3) either a) cranial symptoms, b)
             new-onset extremity claudication or c) weight loss >5 kilograms or fever>38oC for >3
             weeks and a clinical diagnosis of giant cell arteritis judged by expert
             rheumatologist.

        Controls:

          -  age-(+/-3 years) and sex-matched malignant melanoma (MM) patients

          -  follow-up metastatic-disease-free FDG PET/CT ≥6 months after MM resection

        Exclusion Criteria:

          -  Previous diagnosis of polymyalgia or giant cell arteritis

          -  immunosuppresive treatment within last month
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment