Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Serum IL-17 Correlated With Inflammatory Changes in Osteoarthritis and Rheumatoid Arthritis

Eligibility criteria:
Inclusion Criteria:

          -  A patient is considered having definite RA if he/she scores at least 6 points in the
             established classification system

          -  A patient is considered having Hand OA if he /she Hand pain, aching, or stiffness plus
             3 or 4 of hard tissue enlargement of 2 or more of 10 selected joints or hard tissue
             enlargement of 2 or more DIP joints or fewer than 3 swollen MCP joints, or deformity
             of at least 1 of 10 selected joints which are are the second and third distal
             interphalangeal (DIP), the second and third proximal interphalangeal, and the first
             carpometacarpal joints of both hands

        Exclusion Criteria:

          -  Any subject with liver diseases, coronary artery diseases, kidney diseases or other
             inflammatory conditions was excluded from the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Gastric Cancer Registry for Epidemiology and Molecular Risk Factor

Eligibility criteria:
Inclusion Criteria:

          -  The patients who were diagnosed of primary gastric adenocarcinoma and drew up
             agreement for understanding and enrollment of this study.

        Exclusion Criteria:

          -  Being treated (surgery, endoscopic resection and chemoradiation) after the diagnosis
             of gastric cancer; metastatic gastric cancer; refusal to participation of this study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effects of Resistance Training in Body Composition and Body Image Perception of Women Throughout the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Sedentary or Active

          -  18.5-34.9 kg/m2 BMI

          -  Normal menstrual cycle defined as 28 to 30 days and a duration of 3 to 7 days

          -  Age range is 18-45 years old

          -  The inclusion of other participants may alter the results as an increase in body fat
             has been linked to known changes in different hormonal levels and those changes might
             influence substrate utilization

          -  Changes in the hormonal status of pre-menopausal women may appear without symptoms

          -  Younger females also display variations in their hormones since they are going through
             the process of development

        Exclusion Criteria:

          -  Previous physiological and mental health history

          -  Pregnant females

          -  Males

          -  Irregular menstrual cycle, menstrual dysfunction or unusual sex hormone levels

          -  Musculoskeletal injuries

          -  Contraceptives, a medication that alters hormonal or cardio-respiratory responses

          -  Pre-menopausal symptoms

          -  On moderate to high-intensity exercise regime more than 2 days/week
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Targeted Dose Finding of Canakinumab (ACZ885) for Management of Acute Flare in Refractory or Contraindicated Gout Patients

Eligibility criteria:
Inclusion Criteria:

          -  History of at least 1 gout flare prior to the Screening Visit

          -  Meeting the American College of Rheumatology (ACR) 1977 preliminary criteria for the
             classification of acute arthritis of primary gout.

          -  Presence of acute gout flare for no longer than 5 days.

          -  Baseline pain intensity > or = to 50 mm on the 0-100 mm VAS.

          -  Contraindicated for, intolerant or unresponsive to NSAIDs, colchicine or both.

        Exclusion Criteria:

          -  Rheumatoid arthritis, evidence/suspicion of infectious/septic arthritis, or other
             acute inflammatory arthritis.

          -  Presence of severe renal function impairment

          -  Contraindication to intramuscular injection

          -  Known presence or suspicion of active or recurrent bacterial, fungal or viral
             infection at the time of enrollment

          -  Evidence of active pulmonary disease

          -  Live vaccinations within 3 months prior to the start of the study

          -  Use of forbidden therapy

        Other protocol-defined inclusion/exclusion criteria applied
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Von Willebrand Disease in the Netherlands

Eligibility criteria:
Inclusion Criteria:

          -  Historically lowest VWF:Ag and/or VWF:RCo and/or VWF:CB ≤ 0.30 IU/mL and/or FVIII:C ≤
             0.40 IU/mL

          -  Treatment at a Hemophilia treatment center in the Netherlands

          -  All types of VWD

          -  All ages

        Exclusion Criteria:

        - Other known bleeding disorders present.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Association Between the Menstrual Cycle and Weight Loss

Eligibility criteria:
Inclusion Criteria:

          -  Healthy females between the ages of 18-40 (inclusive)

          -  BMI between 26.5-35.4 kg/m² (inclusive)

          -  Regular menstrual cycle (28 ± 3 days)

          -  Weight stable (within ± 3-kg) 2 months prior to study inclusion

          -  Must use barrier contraception (e.g. male/female condom) for the study's duration

          -  Must be willing to follow the prescribed diet/exercise plan for the study's duration

        Exclusion Criteria:

          -  On hormonal contraceptives or any other daily use of medications which can make the
             subject unsuitable for inclusion in the study.

          -  Any significant health problem (history of cancer, HIV/AIDS, Diabetes, cardiovascular
             disease, untreated hypothyroidism, etc.)

          -  Restrictions against participating in cardiovascular exercise and strength training

          -  Any condition, which in the opinion of the investigator makes the subject unsuitable
             for inclusion in the study.

          -  Women who are pregnant, lactating, or planning to become pregnant during the study
             period
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained infertility

          -  Both ovaries are present

          -  Day 2 FSH <10 mIU/L

          -  Day 2 Estradiol <80 pg/L

        Exclusion Criteria:

          -  Known other cause of subfertility

          -  Expected poor responders according to Bologna criteria (9)

          -  Abnormalities affecting the uterine cavity

          -  Uncontrolled diabetes

          -  Allergy to gonadotrophins

          -  Cancelled cycles during the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Effects of Aerobic Exercise for Treating Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable or possible Alzheimer's disease (AD);

          -  15≤ Mini-Mental State Examination (MMSE) score ≤26;

          -  Clinical Dementia Rating score 0.5-2;

          -  Community-dwelling, e.g., homes and assisted living;

          -  Age 66 years and older;

          -  English-speaking;

          -  Verified exercise safety by the primary care providers and the cardiologists if
             subjects have significant cardiac history;

          -  Stable on AD drugs >1 month if AD drugs are prescribed.

        Exclusion Criteria:

          -  Resting heart rate (HR) ≤50 or ≥100 beats/min;

          -  Neurological disorders in the past 5 years;

          -  Psychiatric disorders in the past 5 years;

          -  Alcohol or chemical dependency in the past 5 years;

          -  Contraindications to exercise;

          -  New symptoms or diseases that have not been evaluated by a health care provider, e.g.,
             hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein
             thrombosis, hernia, unhealed sores, joint swelling, pain or trouble walking;

          -  Cardiac ischemia or serious arrhythmia on the electrocardiograph during the screening
             exercise test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 66 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of GCA, meeting at least 3 of the following 5 American College of
             Rheumatology (ACR) criteria for the diagnosis of GCA:

               1. At least 50 years of age at disease onset

               2. New onset or new type of localized pain in the head

               3. Temporal artery abnormality (i.e., temporal artery tenderness to palpation or
                  decreased pulsation unrelated to arteriosclerosis of cervical arteries)

               4. ESR of greater than 40 mm in the first hour by the Westergren method

               5. Temporal artery biopsy showing vasculitis characterized by a predominance of
                  mononuclear cell infiltration or granulomatous inflammation, usually with
                  multinucleated giant cells

          -  Corticoid treatment since less than 14 days

          -  Signed informed consent

          -  Affiliation to the social security system

        Exclusion Criteria:

          -  Dementia

          -  Predictable non observance

          -  Neoplasia since less than 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment