Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain

Eligibility criteria:
Inclusion Criteria:

          -  Chronic (lasting a long time) primary osteoarthritis knee pain, one or two side with
             stage II Kellgen-Lawrence, for more than 3 months with Visual Analogue Scale (VAS)
             more than 4

          -  Good knee deformity, no limit range of motion

          -  Participant who has signed the informed consent form

        Exclusion Criteria:

          -  Skin disease that prevents the use of the transdermal system or which could affect the
             absorption of fentanyl or local tolerability

          -  History or suspicion of alcohol or drug abuse within the past 5 years

          -  History of cardiac, nervous system or respiratory disease which in the investigator's
             judgment prevents participation in the study because of the potential for respiratory
             depression

          -  Confusion, reduced level of consciousness, or concomitant psychiatric disorder which,
             in the opinion of the investigator, could prevent participation in the trial

          -  Participants who do not understand or speak Thai
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of congenital haemophilia A or B with inhibitors development against FVIII
             or FIX, respectively

        Exclusion Criteria:

          -  Prophylactic administration of any haemostatic drug within 3 last months prior to
             entering the trial.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Isolation of the Spermatic Cord in Mesh Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of a primary unilateral inguinal hernia

        Exclusion Criteria:

          -  Medically unfit for surgical repair
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  Patients presenting with a clinical picture that assumes the diagnosis of erosive oral
             lichen planus (bilateral, more or less symmetrical erosive lesions with lacelike
             network of slightly raised gray white lesions (reticular pattern), and a histological
             findings that confirms the diagnosis (liquefaction degeneration of the basal cell
             layer with irregular-saw teeth like rete pegs.

        Exclusion Criteria:

          -  Systemic disorders such as hematological diseases, severe cardiovascular diseases,
             treatment with any drugs that could cause Lichenoid reaction.

          -  Pregnancy or active breastfeeding

          -  Patients who had lesion/lesions with dysplasia

          -  Patients who received topical treatment for Oral Lichen planus in the last 2 weeks
             (Lee et al., 2013) or systemic treatment for OLP in the past 3 months.

          -  Platelet count < 150,000/mm3; Hgb < 11 g/dl.

          -  Immunosuppressed patients

          -  Patients receiving therapy with anticoagulants and use of non-steroidal
             anti-inflammatory drugs in the 5 days before taking the blood sample.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Salivary Catecholamines in Aphthous Stomatitis (Canker Sores)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 or older, both genders

          -  History of recurrent aphthous ulcers with 4 or more episodes per year

        Exclusion Criteria:

          -  History of salivary gland disease including Sjogren's disease, parotitis, and
             sialolithiasis

          -  History of benign or malignant salivary gland tumor

          -  History of celiac disease, ulcerative colitis or Crohn's disease

          -  Patients on medications that affect salivary flow such as anti-depressants and
             anti-cholinergic medications
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients

Eligibility criteria:
Inclusion Criteria:

          -  Subjects who seek medical advice in primary care for symptoms thought to be GERD
             related (GERD is a condition which develops when the reflux of stomach content causes
             troublesome symptoms and / or complications).

        Exclusion Criteria:

          -  Subjects with any clinical GERD treatment (PPI, H2-receptor antagonists) within the
             last 3 months prior to Visit 1.

          -  A history of severe esophagitis or known other complications, with alarm symptoms
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Pilot Study for Imaging of the Esophagus Using a Tethered Capsule OCT Endomicroscopy in the Primary Care Setting

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must be scheduled for non-urgent appointment at primary care practice
             including annual wellness visits and routine follow-up appointments.

          -  Subjects must be over the age of 18

          -  Subjects must be able to give informed consent

          -  Subjects must have no solid food for 4 hours prior to the procedure, and only clear
             liquids for 2 hours prior to the procedure.

        Exclusion Criteria:

          -  Subjects with current symptoms of dysphagia

          -  Subjects with any history of intestinal strictures, prior GI surgery, or history of
             intestinal Crohn's disease.

          -  Subjects with current symptoms of fever, nausea or sore throat at the time of the
             appointment.

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel in Adult Hypogonadal Males

Eligibility criteria:
Inclusion Criteria:

          -  Males between 18-75 years of age

          -  Two fasting serum testosterone levels <300 ng/dL

        Exclusion Criteria:

          -  Previous use of the study drug

          -  History of prostate or breast cancer

          -  Prostate-Specific Antigen (PSA) ≥3 ng/mL

          -  Subject is sexually active and not willing to use adequate contraception
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: An Examination of the Value of Shortwave Diathermy and Hydrotherapy for Patients With Osteoarthritis of Their Knees

Eligibility criteria:
Inclusion Criteria:

          -  Patients had to have a documented diagnosis of osteoarthritis of their knees.

          -  Patients had to be between 50 and 70 years inclusive.

          -  Patients had to have X-ray evidence of osteoarthritis of their knees.

        Exclusion Criteria:

          -  Patients with another rheumatological condition other than osteoarthritis.

          -  Patients who were unable to understand the concepts, assessment and treatment
             involved.

          -  Patients who had received a cortisone injection into the knee in the previous 30 days.

          -  Patients for whom CSWD or hydrotherapy has been contraindicated.

          -  Patients who have had either CSWD or hydrotherapy in the past.

          -  Patients who had undergone a surgical procedure on either lower limb in the past 6
             months.

          -  Patients who were receiving other physiotherapy treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  65 years or older

          -  Diagnosed with osteoporosis (Bone Mineral Density (BMD) T-score <= -2.5 at spine or
             hip) or prior fragility fracture BMD T-score <=-1.5 in at least one of the anatomic
             sites including lumbar spine, total hip, and femoral neck sites

          -  Postmenopausal

          -  Low levels of vitamin D as measured 25-hydroxyvitamin D

          -  Has fallen at least once within the past 12 months

        Exclusion Criteria:

          -  Unable to stand or sit upright for at least 30 minutes

          -  Has a bone disorder other than osteoporosis

          -  Contraindication to the use of FOSAVANCE
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction