Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: A Phase IIb Multicentre, Double-Blind, Dose-Ranging, Randomised, Placebo-Controlled Study Evaluating Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Adult male subject aged 18 to 65 years inclusive

          -  BMI > 30 kg/m2 and < 50 kg/m2

          -  Serum total testosterone concentration below the normal range

          -  LH levels below the upper limit of normal

          -  Oestradiol levels within or above the normal range of approved assay

          -  At least two symptoms of androgen deficiency present for at least 2 months prior to
             the first Screening Visit, with at least one of these being a sexual dysfunction

        Exclusion Criteria:

          -  Evidence of clinically significant endocrinopathy at screening that may interfere with
             the study assessments

          -  Other types of hypogonadotropic hypogonadism or primary hypogonadism

          -  Any other pituitary or hypothalamic disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus

Eligibility criteria:
Inclusion Criteria:

          -  clinically and histologically confirmed painful Erosive or Atrophic OLP

          -  free from any systemic diseases using medical questionnaire guided by Cornell Medical
             Index

        Exclusion Criteria:

          -  history of drug induced lichenoid lesions

          -  potential treatment of OLP for less than 2 weeks by topical and 4 weeks systemic
             therapy before study start

          -  pregnant or breast-feeding women,

          -  smoking and

          -  known hypersensitivity or severe adverse effects to the treatment drugs or to any
             ingredient of their preparation

          -  loss of paliability or flexibility in the tissues involved by the oral lesions or
             histological signs of epithelial dysplasia or lichenoid lesions within the biopsied
             sites.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Effectiveness Intraarticular Corticosteroid

Eligibility criteria:
Inclusion Criteria:

          -  patients with established RA

          -  age between 18 and 65 years

          -  disease modifying anti-rheumatic drugs (DMARDs) stable for at least 3 months

          -  synovitis in wrist with pain visual analogic scale (VAS) between 4 and 8cm

        Exclusion Criteria:

          -  patients with overlap syndromes

          -  polyarticular synovitis

          -  diabetes mellitus or uncontrolled hypertension and those with suspected local or
             systemic infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Long-term Lifestyle Change and Testosterone Replacement

Eligibility criteria:
Inclusion Criteria:

          -  Overweight/obese (BMI = or > 27 kg/m2)

          -  Older (65-85 yr)

          -  Male veteran patients being seen at the PI's endocrine clinic and receiving standard
             of care consisting of diet and regular exercise counseling

          -  Diagnosed with hypogonadism on current or previous testosterone replacement at the
             PI's endocrine clinic

          -  Willing to provide informed consent

        Exclusion Criteria:

          -  Failure to provide informed consent

          -  Unstable cardiopulmonary disease (e.g. recent MI, unstable angina, stroke) or unstable
             disease (Class III or IV congestive heart failure).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Rapid HIV Testing Program in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

        One of the following conditions:

          -  Sexually transmitted disease evaluation or prior history of sexually transmitted
             disease

          -  Pregnancy

          -  Clinical condition that suggests possible immunodeficiency

          -  History of illicit drug use

          -  History of chronic viral hepatitis

          -  Patients with unexplained pneumonia or recurrent pneumonia

          -  Male patients who have a history of sex with men

          -  Abdominal pain in a sexually active woman or urethritis in a man

          -  Trauma.

          -  Age 18 years old or older.

        Exclusion Criteria:

          -  Age less than 18 years.

          -  None of the above conditions.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Study on the Correlation of Free Vitamin d With BMD and Fracture

Eligibility criteria:
Inclusion Criteria:

          -  patients with a diagnosis of osteoporosis and with or without fracture

          -  post- menopausal women

          -  age > 48 years

        Exclusion Criteria:

          -  vitamin D supplementation in recent 6 months

          -  patients on steroid

          -  age < 48 years

          -  patients with chronic diseases such as liver cirrhosis, renal failure, hypertension,
             hyperparathyroidism
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 48 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Targeted Next Generation Sequencing and Intellectual Disability

Eligibility criteria:
Inclusion Criteria:

          -  Moderate or severe intellectual disability

          -  Availability of patient and parent DNA

          -  No etiologic diagnosis with standard approaches: negative fragile X, normal pangenomic
             180K and 1M array-CGH

          -  Informed consent of person having parental authority

        Exclusion Criteria:

          -  Non availability of parent DNA

          -  Patient lost to follow-up
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  age more than 20 years old and less than 70 years old

          -  typical gastroesophageal reflux symptoms (heart burn and acid reflux)

          -  outpatient

          -  complete upper gastrointestinal endoscopy

        Exclusion Criteria:

          -  age less than 20 years or more than 70 years old

          -  receive medication for reflux disease (including proton pump inhibitor, histamine type
             2 receptor blocker, prokinetic agents) in previous one month

          -  pregnant women

          -  history of abdominal surgery

          -  severe comorbidity with cirrhosis, end-stage renal disease, heart failure

          -  no written informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Dry Needling for Patients With Back Pain

Eligibility criteria:
Inclusion Criteria:

          -  Primary complaint of back pain

          -  Modified Oswestry Disability Index > 10 points=20%

        Exclusion Criteria:

          -  Red flags noted in the patient's Low Back Medical Screening (i.e. tumor, fracture,
             metabolic diseases, Rheumatoid Arthritis, prolonged history of steroid use, pregnancy,
             ankylosing spondylitis, cauda equina).

          -  Use of high doses of blood thinners

          -  Evidence of central nervous system involvement, to include hyperreflexia, sensory
             disturbances in the lower extremity, intrinsic muscle wasting of the hands,
             unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of
             the face, altered taste, the presence of pathological reflexes (i.e. positive
             Hoffman's and/or Babinski reflexes), etc.

          -  Workers compensation or pending legal action regarding their back pain

          -  Insufficient English language skills to complete all questionnaires

          -  Inability to comply with treatment and follow-up schedule
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Observational Study in Diagnosed Patients COVID-19, Supported on an Outpatient Basis. (COVID-PSL)

Eligibility criteria:
Inclusion Criteria:

          -  Age >18 years

          -  COVID PCR + patient: Patient screened positive by PCR on nasopharyngeal swab

          -  or COVID-like patient: Patient not screened, but considered COVID + because contact
             with a COVID PCR + person, and presenting symptoms suggestive of COVID-19 among:

          -  Influenza-like illness (fever, body aches, arthralgia, etc.)

          -  Respiratory form: dyspnea, cough, rhinitis

          -  Gastrointestinal form: diarrhea, nausea, vomiting

          -  Anosmia and / or ageusia

          -  or patient COVID PCR-: If patient tested negative by PCR on nasopharyngeal swab, but
             showing signs suggestive of COVID-19.

        Exclusion Criteria:

          -  Patient objecting to the use of their data for research purposes

          -  Patient under justice or deprived of liberty.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment