Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product.

Eligibility criteria:
Inclusion Criteria:

          -  Male or female patients, age between 18 to 60 years

          -  With the data of serum uric acid level more than 8.0 mg/dl within 2 weeks before the
             initiation of study

          -  Signed informed consent obtained prior to inclusion into the study

        Exclusion Criteria:

          -  Pregnant women.

          -  Acute onset of gouty arthritis or renal stone

          -  Significant liver or renal dysfunction, hematological disease, oncological disease, or
             other life threatens disorders.

          -  Condition that need the management of diuretics or analgesics agent

          -  Have been administrated by anti-hyperuricemia agent or healthy food with in 4 weeks
             before the initiation of study.

          -  The serum uric acid level could be decrease to lower than 8 mg/dl by diet control.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Celebrex In Acute Gouty Arthritis Study

Eligibility criteria:
Inclusion Criteria:

          -  Acute gouty arthritis meeting the American College of Rheumatology (ACR) criteria for
             acute arthritis of primary gout;

          -  Onset of pain from an acute gouty arthritis attack within 48 hours prior to
             Screening/Baseline (Visit 1);

          -  A rating of moderate, severe, or extreme (2, 3, or 4, respectively) on the Patient's
             assessment of pain intensity in the index joint (5-point scale:0-4) at
             Screening/Baseline.

        Exclusion Criteria:

          -  Diagnosis of any other type of arthritis including those types suspected of being
             infectious in origin in the index joint or presence of any acute trauma of the index
             joint. Patients with osteoarthritis will be included as long as it is mild or moderate
             (according to investigator's criteria) and it does not affect the index joint;

          -  Acute polyarticular gout involving greater than 4 joints or chronic gout.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Mü-opioid Receptor Level and Postoperative Pain in Patients With Gynecological Laparoscopy

Eligibility criteria:
Inclusion Criteria:

          -  Volunteer,

          -  Between the Ages of 18-45,

          -  Least Primary School Graduate,

          -  Not Using Drugs That May Affect Cognitive Functions,

          -  Non-Alcohol Substance Use,

          -  Patients Without Psychiatric and Neurological Disease.

          -  Those with regular and predictable menstrual cycles

        Exclusion Criteria:

          -  Those with known psychiatric disease and drugs,

          -  Those with an important cardiovascular or central nervous system disease,

          -  Patients with pain syndromes or routinely using opioid,

          -  Those whose menstrual cycles last less than 21 days and do not have an irregular and
             predictable menstrual cycle

          -  Very urgent patients
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Liver Biopsy In Haemophilia Gene Therapy

Eligibility criteria:
Inclusion criteria:

          1. Male and aged 18 to 80 years old

          2. Patients who were enrolled and treated in one of the following clinical trials:

               -  AGT4HB (EudraCT No 2005-005711-17) - FIX AAV gene therapy trial (Sponsor: St Jude
                  Children's Research Hospital)

               -  GO-8 (EudraCT No 2016-000925-38) - FVIII AAV gene therapy trial (Sponsor: UCL)

          3. Patients with endogenous FVIII:C/FIX:C expression at >1% after gene transfer that is
             stably maintained for >6 months and associated with normal prothrombin (PT) and
             thrombin times (TT) as determined in a coagulation assay

        Exclusion Criteria:

          1. Patients with a platelet count measured at <140 x109/L

          2. Any condition that, in the opinion of the investigator or Sponsor would prevent the
             patient from fully complying with the requirements of the study and/or would influence
             or interfere with evaluation and interpretation of subject safety or efficacy result.

          3. Patients with abnormal kidney function (estimated GFR <50ml/min)

          4. Patients with a known allergy to iodine-based intravenous contrast agents

          5. Patients with a known allergy to local or general anaesthetic

          6. Patients with a known reaction to FVIII/FIX concentrate infusions

          7. Presence of FVIII or FIX inhibitor (done within 14 weeks of biopsy)

          8. Evidence of any bleeding disorder not related to haemophilia A or B

          9. Patients unable and unwilling to provide and sign an informed consent.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Biomarker(s) for Glucocorticoids

Eligibility criteria:
Inclusion Criteria:

          -  Primary adrenal insufficiency under stable glucocorticoid replacement therapy (15-30
             mg of Hydrocortisone stable dose the last 3 months) due to autoimmune adrenalitis
             (disease diagnosed at least 12 months before inclusion), age 20-60 years, BMI 20-30
             kg/m2, and ability to comply with the protocol procedures.

        Exclusion Criteria:

          -  Glucocorticoid replacement therapy for indication other than primary adrenal
             treatment, any treatment with sex hormones inclusive contraceptive drugs, treatment
             with levothyroxine, diabetes mellitus, renal or liver failure, significant and
             symptomatic cardiovascular disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations

Eligibility criteria:
Inclusion Criteria:

          -  Ages 18-65, Male or Female

          -  Normal exercise tolerance without dyspnea or clinically important limitation of
             exercise tolerance.

        Exclusion Criteria:

          -  Complicated heart or lung disease

          -  Pregnancy

          -  Complex arrhythmias

          -  Severe Anemia

          -  Uncontrolled Diabetes, hypertension, or untreated thyroid disease

          -  Has any of the following symptoms in the last 21 days: sore throat, cough, chills,
             body aches for unknown reasons, shortness of breath for unknown reasons, loss of
             smell, loss of taste, fever at or greater than 100 degrees Fahrenheit.

          -  COVID-19 test positive within 21 days.

          -  Any Disease that the PI feels will markedly increase the risk of CPET testing
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Comparison of Ideal vs. Actual Weight Base Factor Dosing

Eligibility criteria:
Inclusion Criteria:

          -  Hemophilia A

          -  Able and willing to comply with pharmacokinetic testing schedule

          -  Either overweight or obese BMI using CDC definitions by age

        Exclusion Criteria:

          -  Inhibitor of > 0.6 BU twice in the past, or documented abnormal recovery of less than
             66% (of expected) in the past

          -  Known other bleeding disorder

          -  Known other prolongation in aPTT (lupus anticoagulant, FXII deficiency)

          -  Female
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Cytochrome P450 2E1 and Iron Overload

Eligibility criteria:
Inclusion Criteria:

          -  Male patients aged from 18 to 70 years

          -  Hepatic iron overload measured by magnetic resonance imaging [MRI] (> 36 µmol/g and <
             200 µmol/L)

          -  Homozygosity for the C282Y mutation of the HFE or dysmetabolic iron overload syndrome
             (DIOS) based on the presence of at least one of these following metabolic
             abnormalities:

          -  Overweight: BMI > 25 kg/m2

          -  Waist/hip circumference (cm) > 0.90

          -  Diabetes mellitus (fasting blood glucose level >1.25g/L or blood glucose level after 2
             hours > 2g/L) or glucose intolerance (fasting blood glucose level between 1.10 and
             1.25g/L)

          -  Total cholesterolemia > 6.2 mmol/L or HDL-Cholesterol < 0.9 mmol/L

          -  TG>= 1.7 mmol

          -  Written informed consent

        Non-Inclusion Criteria:

          -  Consumption of alcohol > 50 g/day and of any CYP2E1 inhibitor substances

          -  Smoker > 5 cigarets/day

          -  History of blood donation or venesection

          -  Other causes of iron overload: aceruloplasminaemia, haematological disorder (abnormal
             blood counting), late cutaneous porphyria (cutaneous bullous disorders and
             photosensibilisation) , martial treatment, repeated transfusions.

          -  Inflammatory syndrome (CRP > 3ng/ml)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Electro-acupuncture in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          1. Age 45-75 years old, male or female;

          2. Single / bilateral knee pain, duration of more than 6 months;

          3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 6 months;

          4. NRS ≥ 40mm;

          5. Signed informed consent

        Exclusion Criteria:

          1. Surgery history of knee or waiting for surgery (knee replacement or knee arthroscopy);

          2. Knee pain caused by other diseases (such as joint bodies, severe effusion of joint
             cavity, infection, malignant tumors, autoimmune diseases, trauma, etc.);

          3. History of arthroscopy within 1 year or intra-articular injection within 4 months;

          4. History of receiving acupuncture treatment within 3 months;

          5. Severe acute/chronic organic or mental diseases;

          6. Pregnant women, pregnant and lactating women;

          7. Coagulation disorders (such as hemophilia, etc.);

          8. Participation in another clinical study in the past 3 months;

          9. With a cardiac pacemaker, metal allergy or needle phobia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment