Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effect of TA Contraction on Gait in Patients With Knee OA

Eligibility criteria:
Inclusion Criteria:

          -  those with medical diagnosis (providing written evidence from a physician, physician
             assistant, or nurse practitioner) of knee OA unilaterally or bilaterally.

        Exclusion Criteria:

          -  bilateral total knee arthroplasty, requirement of an assistive device or assistance
             with ambulation, spinal diagnoses which contraindicate participation in spinal
             stabilization activities, and those currently limited by another lower extremity
             pathology at the time of participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Hormonal Effects on the Uterus and Endometrium

Eligibility criteria:
-  INCLUSION CRITERIA:

        Healthy volunteers will be in excellent health.

        Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms,
        diaphragm) or sterilization methods of contraception will be included.

        Only women with a negative pregnancy test, normal physical examination and laboratory
        results, and a luteal phase progesterone value of greater than 4 ng/mL will be entered into
        this study.

        Women with endometriosis will be recruited from those with histologically-proven
        endometriosis. Except for this diagnosis they will meet criteria for healthy volunteers as
        stated above.

        Women may participate in the study on more than one occasion, but biopsies may not be
        performed in a "baseline" cycle.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Setting the Shortest Examination Time of Gastroscopy to Improve the Detection Rate of Upper Gastrointestinal Tumors

Eligibility criteria:
Inclusion Criteria:

          -  No history of benign and malignant tumors (including carcinoma and adenoma) of upper
             GI (including esophagus, stomach and duodenum)

          -  undergo gastroscopy with intravenous anesthesia (or conscious sedation)

        Exclusion Criteria:

          -  Subjects with focal lesions detected by gastroscopy within 1 year

          -  Subjects that cannot stand the gastroscopy procedure or cannot cooperate with
             endosccopists

          -  Emergency endoscopy and therapeutic endoscopy

          -  Subjects with history of esophageal or stomach surgery or endoscopic surgery

          -  Pregnant

          -  Subjects that taking antiplatelet or anticoagulant drugs which contradicts endoscopic
             biopsy

          -  Subjects with other serious complications that affect the speed of gastroscopy

          -  Subjects that refuse to cooperate with data collection or sign the informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Obesity Surgery During 2020 Italian Pandemic

Eligibility criteria:
Inclusion Criteria:

          1. Primary bariatric surgery;

          2. Compensated DMT2;

          3. Controlled hypertension;

          4. Patients with OSAS can only be admitted if therapy with home CPAP is effective

          5. Laparoscopic standard bariatric procedure;

          6. Procedure duration less than 120 minutes;

          7. Official SICOB's surgical informed consent given, including Covid-19 addendum.

        Exclusion Criteria:

          -  previous Covid-19 infection;

          -  patients who may need an extended stay or intensive care (BMI > 60).

          -  concomitant procedure;

          -  previous major abdominal surgery
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: DHEA Versus Placebo in Women With Poor Ovarian Response

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing IVF/ICSI treatment with expected poor ovarian response according to
             the Bologna criteria

        Exclusion Criteria:

          -  Women with BMI >35 Kg/m2

          -  Women with a single ovary

          -  Known allergy to DHEA

          -  Diabetic women on insulin as insulin lowers DHEA levels and might reduce the
             effectiveness of DHEA supplements
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Repair of Tympanic Membrane Perforation Using Tachosil Under Local Anesthesia

Eligibility criteria:
Inclusion Criteria:

          -  chronic tympanic membrane perforation

          -  dry ear at least 4 weeks before the procedure

          -  no evidence of cholesteatoma

          -  hearing test in the last 3 months

          -  signing informed consent

        Exclusion Criteria:

          -  age under 18 years

          -  pregnant

          -  breastfeeding

          -  a known sensitivity for any ingredient

          -  a perforation that is more than one third of the tympanic membrane area.

          -  new onset perforation (less than 3 months)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Effects of Growth Hormone (GH) Treatment on Eating Regulation

Eligibility criteria:
Inclusion Criteria:

          1. Height of at least 2.0 standard deviations below the mean height for chronological age
             and sex according to the 2000 standards from the Centers for Disease Control and
             Prevention (CDC).

          2. Children that have one of the following short stature pathologies:

               1. IGHD or MPHD

               2. ISS

               3. SGA

          3. Proper function of thyroid gland, kidney and liver

          4. Prior to initiating growth hormone treatment

        Exclusion Criteria:

          1. Chronic diseases

          2. Diseases in the digestive system.

          3. Neurological diseases.

          4. Malignant diseases in the past or in the present. Treated with chemotherapy or
             radiation.

          5. Genetic syndromes

          6. Bone diseases

          7. Taking chronic medicine, SSRI type, that effect the appetite and the growth hormone
             signal transduction.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children

Eligibility criteria:
Inclusion Criteria:

          -  Serous Otitis Media for More Then 3 months

          -  Conductive Hearing Loss of More Then 15 decibels.

          -  Tympanometry type B or C.

        Exclusion Criteria:

          -  No History of Tympanostomy Tube Insertion or Adenoidectomy

          -  No Cranio or Facial Malformations

          -  No Acute Upper Respiratory Tract Infection or Acute Otitis Media
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Promoting Female Empowerment at the Household Level Among Couples in Ibadan, Nigeria

Eligibility criteria:
Inclusion Criteria:

          -  Women ages 18-35 years who live with their husbands or partners within the
             pre-selected study clusters

          -  Consent from husband/partner as well as eligible woman

          -  Women in polygynous unions, if the wife co-resides with her husband

        Exclusion Criteria:

          -  Either woman or partner does not give consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  Primary diagnosis of Functional Class I-III osteoarthritis (OA) of the hip or knee

          -  Chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or acetaminophen for
             OA pain

          -  Discontinued all analgesic therapy at Screening

          -  For women of childbearing potential: a woman who is not pregnant and not nursing, and
             who is practicing an acceptable method of birth control

          -  Ability to ambulate

        Exclusion Criteria:

          -  History of allergic reaction or clinically significant intolerance to acetaminophen,
             aspirin, or any NSAIDs, including meloxicam

          -  Requires regular (more than 2 doses per week) use of opioid or opioid combination
             products to control OA pain of the knee or hip

          -  Clinically significant unstable cardiac, respiratory, neurological, immunological,
             hematological, or renal disease

          -  Significant difficulties swallowing capsules/tablets or unable to tolerate oral
             medication

          -  Previous participation in another clinical study of Meloxicam Capsules or received any
             investigational drug or device or investigational therapy within 30 days before
             Screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment