Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Various Type of Genetic Events in Patients With Intellectual Disability

Eligibility criteria:
Inclusion Criteria:

          -  Patients with developmental disabilities

          -  No etiologic diagnosis but suspected genetic cause

          -  Fragile X syndrome research negative

        Exclusion Criteria:

          -  Children born to consanguineous couples

          -  Diagnosis already established or suspected

          -  Identification of an independent etiology
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Association Study Between Periodontal Disease and Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Consent to participate in study

        Exclusion Criteria:

          -  Systemic uncontrolled disease
Male

Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Patient and Partner Perception After Remission of Cushing's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Subject, male or female over 18

          -  Subject presenting a hypercortisolism in remission or controlled by a drug treatment
             for more than one year.

          -  Subject with a good understanding of the French language

          -  Non-institutionalized subject

          -  Subject whose informed consent could be obtained

        Exclusion Criteria:

          -  Minor subject or over 80 years

          -  Subject presenting hypercortisolism in remission for more than 20 years

          -  Major cognitive impairment that does not allow answering a questionnaire

          -  Genetic syndrome responsible for hypercortisolism

          -  Mixed adenoma whose corticotropic share is responsible for hypercortisolism

          -  Pituitary carcinoma

          -  Subject refusing to participate in the study

          -  Subject having no close

          -  Subject whose relative refuses to answer the questionnaires
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Risks and Outcomes Among COVID-19 Patients Admitted to Assiut University Hospitals.

Eligibility criteria:
Inclusion Criteria:

        - Cases aged 18 years and over. Cases diagnosed as COVID-19 by radiology or with positive
        PCR. Cases admitted to Assiut University Hospitals.

        Exclusion Criteria:

          -  Cases less than 18 years old. Cases diagnosed as COVID-19 and discharged from
             emergency department for Home Isolation. Cases express a dissent from the use of their
             data in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 120 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effect of Lateral Wedge Insole for Knee Osteoarthritis Patient in Plantar Pressure, Quadriceps Thickness, Gait and Walking Speed

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis patients

          -  Medial knee pain

        Exclusion Criteria:

          -  Unable to walk independently

          -  Ambulation with device

          -  Any neurologic disease

          -  Rheumatoid arthritis, gouty arthritis

          -  History of lower limbs fracture

          -  History of operation for lower limbs

          -  Any infectious disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy of Three Weekly Injections of a Bacterial-- Sourced Hyaluronate on Pain and Function in Patients With Knee Osteoarthritis (OA)

Eligibility criteria:
Inclusion Criteria:

          -  (1) age 40 years or older, presence of a primary knee OA with knee pain for at least 6
             months despite conservative treatment (rest, physical therapy, orthoses or pain
             medications etc.); (2) had average pain on knee movement of at least 3 cm on a 10-cm
             VAS; (3) had a current Lequesne index score (described below) >7 (possible range,
             0-24); (4) were willing to discontinue all nonsteroidal anti-inflammatory drugs
             (NSAIDs) or other analgesic medication (except for rescue medication) for the duration
             of the study; and (5) were willing to not receive physical therapy or trial of shoe
             modifications or orthoses during the study period.

        Exclusion Criteria:Exclusion criteria included previous orthopedic surgery on the spine or
        lower limbs, knee instability or marked deformity on examination, clinically apparent tense
        effusion of the knee, intra-articular steroid or HA injection in any joint within the past
        6 months, and concomitant inflammatory arthropathy or other rheumatologic, neurological,
        cardiovascular or psychiatric disorders that would interfere with the clinical assessment
        during the study period.

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Single-dose Linaclotide for Capsule Endoscopy Preparation

Eligibility criteria:
Inclusion Criteria:

          -  Schedule for video endoscopy at UVHS

          -  Ability to speak, read and write English

          -  Age >18

          -  Able to provide consent

        Exclusion Criteria:

          -  Prisoner

          -  Woman who is currently pregnant or breastfeeding

          -  Allergy to linaclotide

          -  Patients with known or suspected mechanical gastrointestinal obstruction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion

Eligibility criteria:
Inclusion Criteria:

          -  English or Spanish speaking

          -  Gestational age between 16 weeks 6 days and 20 weeks 6 days gestation by ultrasound
             dating on the day of enrollment

          -  Ultrasound used for dating purposes must be within the last two weeks.

          -  Women 18-50 years of age undergoing surgical termination of pregnancy

        Exclusion Criteria:

          -  Spontaneous fetal demise

          -  Ruptured membranes or intrauterine infection

          -  Fibroids that significantly distort the uterine shape

          -  Uterine abnormality such as unicornuate uterus

          -  Prior transmural myomectomy

          -  Severe oligohydramnios

          -  Morbid obesity with BMI>45

          -  Inability to place osmotic dilators
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Individualized Dietetic Intervention-eating Habits in Obese Hispanic Children of Low Socioeconomic Status

Eligibility criteria:
Inclusion Criteria:

          -  Attendance from first to sixth grade

          -  Ages 6-12 years

          -  BMI ≥ 85th percentile for age and sex

          -  Hispanic origin

          -  Both parents Hispanic

          -  Low socioeconomic status

          -  Signed consent from both parents/care givers and active assent from children

        Exclusion Criteria:

          -  Disapproval by the children's physician due to any at-risk medical condition known by
             the parents
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: LNG-IUS for Treatment of Dysmenorrhea

Eligibility criteria:
Inclusion Criteria:

          1. Women have dysmenorrhoea and/or chronic pelvic pain secondary to adenomyosis.

          2. Planning for birth spacing for at least 2 years.

          3. Patient aged between 20-45 years old.

          4. Ultrasonographic and Doppler examination suggestive of adenomyosis.

          5. Living in a nearby area to make follow-up reasonably possible.

        Exclusion Criteria:

          1. Pregnancy

          2. Evidence of defective coagulation.

          3. History or evidence of malignancy.

          4. Hyperplasia in the endometrial biopsy.

          5. Incidental adnexal abnormality on ultrasound.

          6. Contraindications to COCs.

          7. Absolute contraindication of LNG-IUS insertion.

          8. Previous endometrial ablation or resection

          9. Uninvestigated postcoital bleeding

         10. Untreated abnormal cervical cytology
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy

Eligibility criteria:
Inclusion Criteria:

          -  Hemodynamic stability

          -  Initial β-hCG <2000 mIU / mL

          -  Titers of β-hCG in decline in 48 hours before treatment

          -  Adnexal mass <5.0 cm

          -  Desire for future pregnancy

        Exclusion Criteria:

          -  Alive embryo

          -  Ectopic pregnancy other than in tubal location

          -  Pregnancy of unknown location
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction