Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Comparison of Blood Levels of Two Formulations of the Selective Hormone Receptor Modulator CDB-2914

Eligibility criteria:
INCLUSION CRITERIA:

        General inclusion criteria:

        Female gender--to evaluate effects in the target population for clinical trials.

        In good health. Chronic medication use is acceptable except for glucocorticoid use. Other
        chronic medication use may be acceptable at discretion of the principal investigator.
        Interval use of over-the-counter drugs is acceptable but must be recorded.

        Hemoglobin greater than 10 g/dL.

        Willing and able to comply with study requirements.

        Age 18 to 50.

        Additional inclusion criteria for pre-menopausal women:

        Using mechanical (condoms, diaphragms), abstinence, oral contraceptive, IUD or
        sterilization methods of contraception for the duration of the study. Because the effect of
        CDB-2914 on IUD efficacy is not known, women using this form of birth control will be
        advised to use barrier methods during the cycle(s) in which they participate.

        Negative urine pregnancy test within one week of the first study. If the second study
        occurs in a subsequent cycle, the pregnancy test will be repeated.

        EXCLUSION CRITERIA:

        Significant abnormalities in the history, physical or laboratory examination

        Pregnancy

        Lactation

        Use of oral, injectable or inhaled glucocorticoids or megesterol within the last year

        Unexplained vaginal bleeding

        History of malignancy within the past 5 years

        Use of anti-epileptic agents
Female
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Effects of 650nm Low Energy Light on Human Retina and Choroid Microcirculation

Eligibility criteria:
Inclusion Criteria:

          1. Age from 7 to 17 years old or from 18 to 45 years old;

          2. Meet the diagnostic criteria for patients with simple low or moderate myopia, with
             diopter < -6.0d and eye axis < 26.0mm;

          3. Transparent refractive stroma, no other eye diseases except nearsightedness;

          4. Agree to participate in the clinical study and sign the informed consent.

        Exclusion Criteria:

          1. Other ocular lesions, such as uveitis, retinal/choroidal vascular lesions, congenital
             ocular lesions, glaucoma, high myopia (ocular axis > 26cm), degenerative retinal
             disease, optic neuropathy, etc.;

          2. Another eye with low vision

          3. Corneal edema/epithelial detachment, corneal opacity;

          4. Redness, pain, dry eye, photophobia, difficulty in opening eyes;

          5. Had a history of eye surgery in recent 3 months;

          6. Severe impairment of liver and kidney function and/or serious systemic diseases (such
             as cardiovascular, respiratory, digestive, nervous, endocrine, genitourinary, etc.);

          7. Women who are already pregnant, preparing for pregnancy during the study period and
             lactating;

          8. A history of substance abuse or alcohol abuse;

          9. Receiving prevention and control treatment for myopia other than glasses within the
             first 30 days;

         10. Any situation in which the study physician believes that the patient's condition will
             interfere with the clinical study (e.g., the patient is prone to nervous tension,
             uncontrollable emotions, depression, etc.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effects of Joint Effusion on Proprioception

Eligibility criteria:
Inclusion Criteria:

        Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):

          1. Kellgren and Lawrence (K/L) grade ≥II

          2. morning stiffness <30 min in duration

          3. crepitus on movement of the knee joint

          4. bony tenderness at the knee joint margins

          5. palpable or visible bony enlargement

          6. no palpable warmth.

        Exclusion Criteria:

          1. the presence of knee joint effusion determined by ultrasonography

          2. a history of knee injury or surgery

          3. a history of knee injection within 3 months

          4. a history of inflammatory arthritis

          5. taking anticoagulants

          6. balance or gait disturbance

          7. diabetes mellitus.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner

Eligibility criteria:
Inclusion:

          -  2-6 years old

          -  complete ophthalmic examination including cycloplegic refraction conducted on the same
             day or within 3 months

          -  strabismic, anisometropic, or normal (normal eye examination and refractive error
             according to AAPOS guidelines)

          -  parent provides informed consent

        Exclusion:

          -  other ocular disease (includes media opacities, anomalous optic nerve, ptosis, lid
             hemangioma, conjunctivitis, blepharitis, symptomatic NLD) or systemic disease (JIA,
             JRA, neurofibromatosis)

          -  developmental delay

          -  strabismus surgery in the past 6 months
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.
Subject must be at most 6 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Elastic Abdominal Binder After Open Abdominal Surgery for Benign Gynecologic Conditions

Eligibility criteria:
Inclusion Criteria:

          -  Women, diagnosed with benign gynecologic conditions, undergoing open abdominal surgery

        Exclusion Criteria:

          -  Surgeries performed for cancer

          -  Intraoperative accidental injury to urinary or gastrointestinal organs

          -  Postoperative admission to intensive care unit (ICU)

          -  Postoperative intraperitoneal drain placement

          -  Unable to understand and follow oral/written instructions

          -  Severe neuromuscular or circulatory disorders
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Primary Ventral or Incisional Hernias

          -  Scheduled to undergo hernia repair through an open approach

          -  Hernia repair performed in an elective setting

          -  Hernia repair performed through a midline incision

          -  Hernia repair performed in a clean wound

          -  Hernia repair performed with mesh placed in the retromuscular position

        Exclusion Criteria:

          -  patients with less than 18 years old of age

          -  patients scheduled to undergo a minimally invasive hernia repair

          -  patients where hernia repair is planned to be performed with mesh placement in a
             different position than retromuscular

          -  patient undergoing hernia repair with a clean-contaminated, contaminated or infected
             wound

          -  patients undergoing hernia repair in an non-elective fashion

          -  patients with allergy, hypersensitivity or contraindication to bupivacaine

          -  patients with history of chronic liver disease with moderate or severe impairment in
             liver function defined as a Child-Pugh class B or C

          -  patients with chronic kidney disease on dialysis

          -  chronic opioid users, defined as daily or near daily use of opioids for at least 90
             days in the past year

          -  patients unable to provide informed written consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: To Verify the Efficacy of Z-338 in Subjects With Functional Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  Subjects showing at least one of the 4 symptoms (upper abdominal pain, upper abdominal
             discomfort, epigastric pain, epigastric burning) for at least 6 months before
             obtaining informed consent

          -  Subjects showing two or more of the following symptoms: upper abdominal pain, upper
             abdominal discomfort, post-prandial fullness, upper abdominal bloating, early satiety,
             nausea, vomiting and/or excessive belching for at least 3 months (one of them should
             be post-prandial fullness or early satiation)

          -  Bothersome symptoms should be post-prandial fullness, upper abdominal bloating or
             early satiety at the time of obtaining informed consent

        Exclusion Criteria:

          -  Subjects with structural disease that is likely to explain the symptom (e.g., GERD,
             erosion, ulcer, hiatal hernia, bleeding, malignancy or Barrett's esophagus) confirmed
             by upper endoscopy at the obtaining informed consent

          -  Subjects have heartburn in last 12 weeks before obtaining informed consent

          -  Subjects with irritable bowel disease (IBS)

          -  Subjects with diabetes mellitus requiring treatment

          -  Subjects with serious anxiety disorder

          -  Subjects with depression and/or sleep disorder

          -  Subjects with biliary tract disease and/or pancreatitis (including chronic
             pancreatitis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: SPI-1005 for the Treatment of Meniere's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Adult males/females, 18-75 years of age at the time of enrollment.

          -  Diagnosis of definite Meniere's Disease by AAO-HNS Amended 2015 Criteria.

          -  Hearing loss of ≥30 dB at 250, 500, or 1000 Hz at study enrollment.

          -  At least two of three active symptoms (tinnitus; aural fullness; vertigo or dizziness)
             of Meniere's disease by AAO-HNS Amended 2015 Criteria, within 3 months of study
             enrollment.

        Exclusion Criteria:

          -  Current, or within 60 days prior to study enrollment, use of IV ototoxic medications

          -  History of otosclerosis or vestibular schwannoma.

          -  History of significant middle ear or inner ear surgery in the affected ear.

          -  Conductive hearing loss with air-bone gap ≥15 dB, otitis media, or mixed hearing loss.

          -  Significant cardiovascular, pulmonary, hepatic, renal, hematologic, gastrointestinal,
             endocrine, immunologic, neurological, or psychiatric disease.

          -  Current use or within 30 days prior to study enrollment systemic steroids.

          -  Current use or within 7 days prior to study enrollment intratympanic steroids.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment