Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®

Eligibility criteria:
Inclusion Criteria:

          -  May be either male or female

          -  Age: 18 years or older

          -  Subjects with a single-rooted tooth (except mandibular incisors) indicated for
             extraction

          -  Extractions socket walls should either be intact or have no more than one bony wall
             (buccal or lingual) dehiscence extending no more than 50% of the total bony wall
             height

          -  Must be in adequate physical and mental health to undergo routine dental treatment
             including the surgical procedures associated tooth extraction and implant placement

          -  Subjects' treatment plan must include replacement of the tooth to be extracted with
             dental implant supported fixed restoration

          -  Subjects must have read, understood and signed an informed consent form

        Exclusion Criteria:

          -  Mandibular incisors

          -  Acute infection associated with the tooth to be extracted or with adjacent teeth

          -  History of significant heart, stomach, liver, kidney, blood, immune system disease, or
             other organ impairment or systemic diseases that would prevent undergoing the proposed
             treatment or may result in compromised healing (e.g. poorly controlled diabetes,
             active heavy tobacco use [>10 cigs/day])

          -  Subjects with uncontrolled and/or severe metabolic bone diseases or disorders, such as
             osteoporosis, thyroid disorders or Paget's disease

          -  Subjects taking any medication or supplement known to largely influence bone
             metabolism, such as IV bisphosphonates, long-term history of oral bisphosphonates or
             chronic intake of glucocorticoids

          -  Pregnant women or nursing mothers

          -  Subjects that are unwilling or unable to sign the informed consent

          -  History of lack of compliance with dental visits

          -  Subjects unwilling to return for the required number of visits
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment