Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS

Eligibility criteria:
Inclusion Criteria:

          1. Patients >18 years

          2. Diagnosis of large vessel vasculitis based on Ultrasonographic and/or Computed
             Tomography Angiography and/or Magnetic Resonance Angiography findings or biopsies of
             the temporal arteries

          3. Fulfill the classification criteria for Giant Cell Arteritis /Takayasu Arteritis

        Exclusion Criteria:

          1. Patients <18 years

          2. Moderate to severe kidney failure

          3. Known allergic reactions to contrast agents

          4. Inability to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

Eligibility criteria:
Inclusion Criteria:

        Healthy men:

        Good general health,

          -  Normotensive,

          -  Normal testosterone levels,

          -  No medications known to influence glucose homeostasis or testosterone levels

        IHH men:

          -  Good general health;

          -  Normal thyroid, adrenal, and GH axes;

          -  Normal prolactin levels;

          -  No abnormalities on imaging of the hypothalamic-pituitary region;

          -  No medications known to influence glucose homeostasis;

          -  Must have been off hormone therapy for a suitable washout period depending on the type
             of prior androgen replacement
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Strategies to Treat Osteoporosis Following a Fragility Fracture

Eligibility criteria:
Inclusion Criteria:

          -  Over 50 years of age

          -  Fragility fracture

          -  Consulting an orthopedic surgeon at the CHUS for treatment of the fracture

        Exclusion Criteria:

          -  No Primary Care Practitioner

          -  Severe co-morbidity requiring specialized care

          -  Failure to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Quantum Natural Family Planning Pilot

Eligibility criteria:
Inclusion Criteria:

          -  • Menstrual cycle ranging between 21-42 days

               -  At least 3 cycles after cessation of breastfeeding

        Exclusion Criteria:

          -  • Not currently on medications that affect ovulation and 3 months prior

               -  Not currently pregnant or breastfeeding

               -  No known fertility problems

               -  Not planning on achieving pregnancy during the 3 menstrual cycles of the study
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Men and women from 18 to 80 years old

          -  Patients recruited during the multidisciplinary consultation of Sjogren's Disease,
             filling the criteria of Sjogren's Disease or patients having a salivary recidivate
             pathology and selected players on the basis of their voluntary service to benefit from
             an ultrasound of the main salivary glands

          -  The patients will have to be capable of adhering to the protocol of study and of
             having understood it.

          -  The patients will have to be capable of giving a signed informed consent, the latter
             being obtained before the inclusion

        Exclusion Criteria:

          -  Not cooperative patient and having refused to sign the informed consent.

          -  Patient incapable to understand the protocol, under guardianship or under
             guardianship.

          -  Unaffiliated patients to the Social Security.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture

Eligibility criteria:
Inclusion Criteria:

          -  post-menopausal women

          -  with a normal Bone Mineral Density (T-score >-1.5) at the 3 sites (lumbar spine, total
             hip and femoral neck) or with osteoporosis (T-score ≤ -2.5) at least at one of the 3
             sites.

        Exclusion Criteria:

          -  Current antibiotherapy or in the last 6 months or repeated antibiotherapy

          -  Current corticotherapy or stopped for less than 6 months

          -  Current treatment of osteoporosis or having lasted more than 3 months in the last 5
             years

          -  Current hormonal treatment for menopause

          -  Current or discontinued drugs that may affect bone metabolism (eg anti-aromatase)

          -  Known hepatic, cardiac or respiratory insufficiency

          -  Pathologies that may affect bone metabolism, particularly severe renal insufficiency

          -  Serious illnesses, particularly disabling and chronic diseases of the gastrointestinal
             tract

          -  Diseases characterized by substantial disorders of the gut microbiota (eg severe
             obesity, BMI> 40 kg / m2, depression, poorly controlled diabetes)

          -  Psychiatric pathology hindering understanding

          -  Difficulty understanding oral French

          -  Person protected by law, unable to express her consent, subject to a protective
             measure or deprived of liberty.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Erythrocyte Apheresis Versus Phlebotomy in Hemochromatosis

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis

               -  Individuals who art homozygous for C282Y or H63D or "compound heterozygous" for
                  these tow variants and have ferritin levels higher than 300 micrograms/L or
                  transferrin saturation higher than 50%.

               -  Individuals heterozygous for C282Y or H63D if ferritin levels higher than 500
                  micrograms/L or transferrin saturation higher than 50%.

          2. Requirements to the patient Body weight higher than 65 kg and initial hemoglobin level
             higher than 12 g/dL.

        Exclusion Criteria:

          1. Contra-indications to either treatment modality

          2. Patients who are not able to co-operate

          3. Lack of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Stated-Preferences in Knee Arthroplasty

Eligibility criteria:
Inclusion Criteria:

          -  Age 40-80

          -  Knee Pain

        Exclusion Criteria:

          -  Inability to read, understand and give effective English consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Plasma RBP Levels in Patients With Idiopathic Hypogonadotrophic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

        decreased serum testosterone concentration below the normal range (serum T < 300ng/dL), FSH
        and LH levels within or below the normal range, absence of a pituitary or hypothalamic mass
        lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH, normal smell
        test and normal karyotypes

        Exclusion Criteria:

        previous androgen treatment, history of smoking, presence of bilateral anorchia,
        intellectual deficiency, diabetes mellitus, arterial hypertension or dyslipoproteinemia,
        medication of any kind and drug abuse. Because of possible confounding effects, patients
        with other hormone deficiencies were excluded.

        -
Male
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 26 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Impact of Biological Point of Care Devices Implementation on the Length of Stay of Patients in Emergency Room

Eligibility criteria:
Inclusion Criteria:

          -  Any patient consulting in the emergency department during the study period

        Exclusion Criteria:

          -  Patients attending the emergency departments as part of dressing or trauma follow-up
             consultations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment