Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effectiveness of the Numerous Educational Strategy Interventions Seeking to Increase the Water Consume in Child

Eligibility criteria:
Inclusion Criteria:

          -  Healthy children

          -  Both girls and boys

          -  Children whose parents agree to participation in the study through verbal informed
             consent

          -  Children whose parents sign a privacy notice

        Exclusion Criteria:

          -  Children who present with any pathology that interferes with the free consumption of
             water or with the proper execution of the study

          -  Children for whom it is not possible to obtain a baseline record of beverage
             consumption
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Eligible participants must:

               -  Have a dermatologic condition, as determined by the PI or AIs, OR be at risk for
                  developing a dermatologic condition, as determined by the PI or AIs, OR be a
                  family member of a person with a dermatologic condition OR be a healthy
                  volunteer, as defined as a person with no known significant health problems.

               -  Be willing to provide biospecimens for research and clinical studies, and for
                  storage to be used for future research.

               -  Subjects of age greater than or equal to 2 years old are eligible.

               -  Ability of subject or Parents/guardian to understand and the willingness to sign
                  a written informed consent document.

        EXCLUSION CRITERIA:

          -  Presence of conditions that, in the judgment of the investigator, may put the subject
             at undue risk or make them unsuitable for participation in the study.

          -  Inability to comply with the requirements of the protocol.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Oral Huzhang Granules for Acute Gouty Arthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of acute gout arthritis as defined by the American College of Rheumatology
             1977 preliminary criteria;

          -  Male or non-pregnant, non-nursing female;

          -  18-70 years of age;

          -  Gout attack less ≤48 hours;

          -  In the week before this observation, non-steroidal anti-inflammatory drugs and
             analgesic drugs and drugs affecting uric acid metabolism were not taken;

          -  Subjects capable of giving informed consent;

        Exclusion Criteria:

          -  failing to meet the diagnostic criteria;

          -  Evidence of uncontrolled concomitant cardiovascular, nervous system,hepatic or
             gastrointestinal disease. Potential participants who have active concomitant disease
             can only be eligible after discussion and agreement with the treating medical team;

          -  the patient is in critical condition and it is difficult to evaluate the effectiveness
             and safety of the clinical observation;

          -  severe deformity, stiffness and labor loss of patients with advanced arthritis;

          -  known allergic to the drug used in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Exhaled Breath Condensate pH in Patients With Cough Caused by Gastroesophageal Reflux

Eligibility criteria:
Inclusion Criteria:

          -  age > 18 years old

          -  able to speak and read English

          -  chronic cough

        Exclusion Criteria:

          -  Cigarette smoking within the past 6 months, or greater than 10 pack year history of
             prior smoking

          -  Any self-reported or clinically diagnosed form of active lung disease, including
             asthma and emphysema

          -  Symptoms of persistent rhinitis within the past three months

          -  Dysphagia

          -  Symptoms of acute viral upper respiratory tract infection or sinusitis within one
             month of entry into the study

          -  Pregnancy - based on self report

          -  Abnormal chest radiograph
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A Proof-of-Concept Study Assessing NEO6860 in Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index (BMI) between 18.0 and 35.0 kg/m2 inclusive;

          -  Patients diagnosed with osteoarthritis of the knee, according to American College of
             Rheumatology (ACR) guidelines, by meeting at least 3 of the following: age > 50,
             morning stiffness < 30 minutes, crepitus on active motion, bone tenderness, bone
             enlargement, no palpable warmth of synovium;

          -  Grade I, II or III using Kellgren-Lawrence classification on an X-Ray of the knee

          -  WOMAC pain subscale ≥ 8

          -  R square of the Focused Analgesia Selection Task (FAST) outcome value greater than
             0.70

        Exclusion Criteria:

          -  Patients with, or with a history of, any clinically significant disorders (including
             fibromyalgia and other painful disorders) which may interfere with the primary
             objectives of the study

          -  Patients treated in the previous 3 months with topical capsaicin or intra-articular
             corticosteroids;

          -  Patients with a contra-indication for the use of Naproxen or acetaminophen;
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Patient- and Physician-Based Osteoporosis Education

Eligibility criteria:
Inclusion Criteria For Patients:

          -  PACE beneficiaries who filled at least one prescription for a drug of any type in the
             year prior to the study

          -  At high risk for osteoporosis: women and men 75 years or older, patients taking
             glucocorticoids or psychoactive medications, patients diagnosed with rheumatoid
             arthritis, and patients with a past fracture

          -  Have had an outpatient visit with a participating doctor based on Medicare outpatient
             claims

        Inclusion Criteria For Physicians:

          -  Primary prescribing physicians for PACE beneficiaries
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature

Eligibility criteria:
Inclusion Criteria:

          -  Girls, with Turner syndrome or ISS; height standard deviation score (SDS) ≤ -2

          -  Bone age ≤ 12 years

          -  Normal birthweight

          -  Body mass index (BMI) = 10th-90th percentile

          -  Normal childhood activity; no physical or other limitations

          -  Normal, balanced diet (20-40% calories from fat)

        Exclusion Criteria:

          -  Puberty (beyond Tanner Stage 1)

          -  Diabetes in subject or first degree relative

          -  Sex steroid therapy

          -  Chronic conditions requiring medication (treatment for hypothyroidism is permissible)

          -  Significant systemic disease (pulmonary, cardiac, renal, or other)

          -  Non-removable metal
Female
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Safety Study of STSP-0601 in Adult Patients With Hemophilia A or B With Inhibitor

Eligibility criteria:
Inclusion Criteria:

          -  18 years old ≤age≤65 years of age,male.

          -  Hemophilia A or B patients with inhibitors.

          -  Peak historical inhibitor titer ≥ 5 BU and a positive inhibitor test when enrolled.

          -  Establish proper venous access.

          -  Provide signed informed consent.

        Exclusion Criteria:

          -  Have any coagulation disorder other than hemophilia A or B.

          -  Treat with prophylactic treatment of coagulation factor.

          -  Treat with anticoagulant within 7d of the time of study drug administration.

          -  Have an active, ongoing bleeding for which the patient is being treated, or treatment
             for a bleeding was stopped within 7d of the time of study drug administration.

          -  Have a history of arterial and/or venous thromboembolic events.

          -  Have platelet count <100,000/mL.

          -  Severe liver or kidney disease.

          -  Accept major operation or blood transfusion within 1 month of the time of screening.

          -  HIV antibody positive.

          -  Have a known allergy to Blood product.

          -  Participate in other clinical research within 1 month of the time of study drug
             administration.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Early Convalescent Plasma Therapy for High-risk Patients With COVID-19 in Primary Care (the CoV-Early Study)

Eligibility criteria:
Inclusion Criteria:

          -  RT-PCR-confirmed COVID-19.

          -  Symptomatic (e.g but not limited to fatigue, fever, cough, dyspnoea, loss of taste or
             smell, diarrhea, falls or confusion)

          -  70 years or older OR 50-69 years and 1 or more of the risk factors described in the
             protocol

        Exclusion Criteria:

          -  Life expectancy <28 days in the opinion of the treating physician

          -  Patient or legal representative is unable to provide written informed consent

          -  Symptomatic for 8 days or more

          -  Being admitted to the hospital at the informed consent procedure

          -  Known previous history of transfusion-related acute lung injury

          -  Known Immunoglobulin A (IgA) deficiency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: The Potential Effects and Mechanisms of Flax Lignans on Type 2 Diabetes Mellitus

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed type 2 diabetes

          -  Age: 50-79 years old

          -  LDL-cholesterol more than 2.9 mmol/l

        Exclusion Criteria:

          -  Current or previous (within 6 months) use of estrogen therapy

          -  Cancer

          -  Chronic gastrointestinal diseases

          -  Current use of antibiotics

          -  Any severe liver or renal diseases

          -  Systolic blood pressure more than 180 mmHg or phase 3 hypertension

          -  Any severe mental diseases

          -  Severe cardio- or cerebro-vascular diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Entailment