Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Efficacy and Safety of Recombinant Factor VIII (GreenGene) in Patients With Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Hemophilia A patients at least 12 years of age

          -  At least 150 treatment exposure-days to previous FVIII products

          -  FVIII≤2% at screening or diagnosis (FVIII≤1% for PK study)

          -  CD4 Lympocyte cell count>400/㎕

          -  Patients willing to cooperate for the study

          -  Patient's or legal guardian's consent to participate in the study

        Exclusion Criteria:

          -  FVIII inhibitor(neutralizing antibody to FVIII)≥0.6 Bethesda Units

          -  Coagulation disorders other than hemophilia A (e.g. Idiopathic Thrombocytopenic
             Purpura, von Willebrand Disease)

          -  Platelet count≤100,000㎣

          -  Subjects with clinical evidence of symptomatic HIV disease regardless of
             HIV-seroposive/seronegative

          -  Subjects with rFVIII antibody, mouse IgG antibody, or CHO antibody

          -  Creatinine levels more than 2 times of reference rage, GOT and GPT levels more than 3
             times of reference range, diabetes mellitus or other metabolic disorder

          -  Subjects with diastolic blood pressure≥100mmHg not controlled with antihypertensive
             medications

          -  Anemia(hemoglobin<12g/dL)

          -  Subjects with severe or life-threatening bleeding just before entry into the trial

          -  Subjects with a history of treatment failure due to formation of inhibitor to FVIII

          -  Subjects with a history of severe hypersensitive reactions to FVIII concentrate

          -  Subjects requiring pre-medication for FVIII infusion(e.g. antihistamines, etc)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: T- XELOX in HER2-positive Stage III Gastric Cancer After D2 Gastrectomy

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed-consent form.

          2. Aged 18-80 years.

          3. Had partial or total D2 gastrectomy and achieved R0 resection.

          4. Histologically confirmed gastric or gastro-oesophageal junction
             adenocarcinoma，mucinous adenocarcinoma ，signet-ring cell carcinoma

          5. Pathologic Stage III (IIIA-C).

          6. HER2-positive: (IHC 3+ or IHC 2+ and FISH positive).

          7. Patients must have received no preoperative chemotherapy or radiation therapy.

          8. Eastern Cooperative Oncology Group (ECOG) performance status 0-2 .

          9. Adequate liver/bone marrow function.Blood and biochemical parameters;

         10. Compliant, and can be followed up regularly.

        Exclusion Criteria:

          1. Patients who do not meet the Inclusion Criteria.

          2. Pregnant or breast-feeding female, or not willing to take contraception measures
             during study.

          3. Serious infection requiring antibiotics intervention during recruitment.

          4. Allergic to study drug or with metabolism disorder.

          5. Histologically confirmed small cell carcinoma of the stomach、gastric neuroendocrine
             carcinoma or others.

          6. Uncontrolled brain metastasis or mental illness.

          7. Organ transplant recipients (Autologous transplantation of bone marrow and peripheral
             stem cell transplantation included).

          8. Congestive heart failure, uncontrolled cardiac arrhythmia, etc.

          9. With severe hepatic/kidney/respirator/disease,or chronic disease like uncontrolled
             diabetes,hypertension,etc.

         10. with other malignant tumors.

         11. Can be followed up or obey protocol.

         12. Ineligible by the discretion of the investigator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effectiveness of Hysteroscopy in the Treatment of Intrauterine Trophoblastic Retentions

Eligibility criteria:
Inclusion Criteria:

          -  Major, under 45 years with intrauterine trophoblastic retention after incomplete
             miscarriage in the first quarter (termination of pregnancy < 14 WA),

          -  With desire of pregnancy ;

          -  Intrauterine trophoblastic retention diagnosed by transvaginal pelvic ultrasound
             finding a intrauterine heterogeneous image or intrauterine gestational sac more than
             15 mm in thickness, complicated or not of endometritis ;

          -  Decision to surgical management of incomplete miscarriage by the health care team ;

          -  Patient beneficiary or affiliated to a health insurance

          -  Informed and signed consent

        Exclusion Criteria:

        Will not be included in the protocol patients :

          -  having a uterine malformation known ;

          -  having received surgical treatment for the current intrauterine retention ;

          -  with intrauterine retention diagnosed by transvaginal pelvic ultrasound of more than
             50 mm in thickness ;

          -  requiring a haemostatic act in urgency for heavy vaginal bleeding (miscarriage
             haemorrhage) ;

          -  bearer of intrauterine device ;

          -  having an evolutive pregnancy;

          -  having an ectopic pregnancy;

          -  having a trophoblastic retention following a voluntary abortion ;

          -  having a pregnancy achieved by medically assisted procreation
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 44 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Confocal Laser Endomicroscopy in Pleural Malignancies

Eligibility criteria:
Inclusion Criteria:

          -  ≥18 years of age

          -  Supected intra-thoracic malignancies with pleural involvement and referred for a
             diagnostic procedure by thoracoscopy, CT guided biopsy or endosonography

        Exclusion Criteria:

          -  Inability and willingness to provide informed consent

          -  Patients with known allergy for fluorescein or risk factors for an allergic reaction

          -  pregnancy or lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Neurologic Examination of Wide and Narrow Tourniquets

Eligibility criteria:
Inclusion Criteria:

          -  self defined Caucasian

          -  clinically healthy

          -  BMI of ≤ 30,

          -  a systolic arterial blood pressure ≤190 mmHg,

          -  no rash or dermatologic condition or tattoos which may interfere with the placement
             site

          -  no neurovascular impairment.

          -  all female participants received a pregnancy test at the initial screening visit.

          -  Study population was restricted to Caucasians to enable an assessment of device caused
             redness or skin lesions, not possible in a mixed study population.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Evaluation of Physical and Cognitive Performance After Simulated Road March Combines Physical and Cognitive Load Using a Virtual Reality Environment

Eligibility criteria:
Inclusion Criteria:

          -  aged 18-30

          -  healthy civilians volunteers

          -  with no background illnesses

          -  with history of combat unit service in the IDF.

          -  fit to perform 10 Km moderate march while carrying load.

        Exclusion Criteria:

          -  The existence or suspicion of existing cardiac or respiratory disease.

          -  Hypertension.

          -  Diabetes.

          -  Any muscles or skeleton condition.

          -  Any hormonal disease or any other chronic illness that may inhibit participation in
             the experiment.

          -  Infectious disease 3 days prior to the experiment.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Natural Cycle vs. Modified Natural Cycle vs. Artificial Cycle Protocol for Endometrial Preparation.

Eligibility criteria:
Inclusion Criteria:

          -  Aged of 18 to 45

          -  Having menstrual cycle duration of 24 to 38 days

          -  Undergoing no more than 3 previous IVF/ICSI - FET cycles

          -  Having indications for frozen-thawed embryo transfer

          -  Agreeing to have no more than 2 embryos transferred

        Exclusion Criteria:

          -  Menopausal/ Anovulatory women

          -  Having contraindication for exogenous hormones administration: breast cancer, risks of
             venous thromboembolism

          -  Having embryos from in vitro Maturation or oocyte donation or PGT (pre-implantation
             genetics testings) cycles

          -  Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/
             bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.

Eligibility criteria:
Inclusion Criteria:

          -  Patients with watery eyes who are listed for punctoplasty surgery

          -  Patients with dry eyes secondary to Sjögren's (i.e. presence of anti-Ro/SSA or La/SSB
             autoantibodies, reduced Schirmer's test less than 5mm over 5 minutes without local
             anaesthesia or typical clinical presentation).

          -  Members of staff at our eye clinic with no history of previous ocular surgery or
             watering/dryness.

        Exclusion Criteria:

          -  Previous eyelid or lacrimal surgery

          -  Patients without capacity to consent

          -  Patients unwilling to participate

          -  Age under 18
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Italian Observational Study Assessing the Impact of Gout on Patients Disability and Quality of Life

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of gout

          -  Must be able to understand questionnaires

        Exclusion Criteria:

          -  Diagnosis not validated by rheumatologist

          -  Not able to sign informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction