Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Histamine Pharmacogenetics in Children With Atopic Dermatitis

Eligibility criteria:
Inclusion Criteria:

          -  Caucasian, Hispanic and African American children ages 6 months to 5 years with a
             diagnosis of atopic dermatitis within the last 12 months will constitute the candidate
             pool for enrollment into the study group. The diagnosis of atopic dermatitis will be
             determined by the presence of at least 3 major diagnostic features (i.e., pruritis,
             rash,relapsing-remitting presentation, family history or atopy) in addition to at
             least 3 minor features (including but not limited to xerosis, elevated serum IgE,
             ocular involvement, food allergy). Healthy Caucasian, Hispanic and African American
             children within the same age range will comprise the pool for enrollment into the
             control group.

        Exclusion Criteria:

          -  Any child with atopic dermatitis who has a documented history of asthma or
             bronchospasm or who is currently receiving treatment for either of these conditions
             will be excluded. Any control subject who has asthma or positive family history of
             allergy or atopic disease in a first-degree relative (biological mother, father or
             siblings) will also be ineligible for enrollment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 5 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Correlates of GERD Symptom Severity

Eligibility criteria:
Inclusion Criteria:

          -  Adults ages 21-70 years old

          -  Heartburn symptoms 3 or more days per week with an average daily symptom severity of 3
             or more on a 7 day baseline symptom diary

          -  English language proficiency

          -  Willingness to be videotaped and connected to physiologic monitoring devices during
             the visit

        Exclusion Criteria:

          -  Diagnosis of Crohn's disease, systemic sclerosis, known active ulcer disease, gastric
             cancer, or untreated/active Barrett's esophagitis based on subject self-report and/or
             medical record review

          -  Heavy alcohol use (> 6 drinks/week for women and > 13 drinks/week for men)

          -  Pregnant women.

          -  Dementia or significant memory difficulties

          -  Severe, unstable psychiatric disease

          -  Greater than 15 doses of nonsteroidal anti-inflammatory drugs (NSAIDS) within the
             prior 30 days (aspirin ≤ 325 mg daily permitted) or ongoing NSAID use at a level
             deemed likely to interfere with the study

          -  Failure to complete the baseline symptom diary for at least 6 of 7 days

          -  Change in GERD treatment regimen within the last 2 weeks (subjects may use antacids,
             H2 receptor blockers, and/or proton pump inhibitors as long as they are symptomatic on
             a stable regimen)

          -  Allergy to adhesives

          -  Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study v1.0

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Patient is > 18 years of age at the time the Informed Consent is signed.

          -  Patient has a pathologically confirmed diagnosis of either Malignant
             Pleural/Peritoneal Mesothelioma (MPM), Serous Ovarian Adenocarcinoma,
             Cholangiocarcinoma, or Non-Small Cell Lung Cancer (NSCLC).

          -  Patient's tumor has been pathologically reviewed by the central laboratory with
             confirmed positive MSLN expression on > 50% of tumor cells that are 2+ and/or 3+ by
             immunohistochemistry.

          -  Prior to gavo-cel infusion, patients must have received at least 1 systemic standard
             of care therapy for metastatic or unresectable disease with more details provided in
             the clinical protocol

          -  Patient has an Eastern Cooperative Oncology Group performance status 0 or 1.

          -  Patient has a left ventricular ejection fraction > 45% as measured by resting
             echocardiogram, with no clinically significant pericardial effusion.

          -  Patient is fit for leukapheresis and has adequate venous access for the cell
             collection.

          -  Patient must have adequate organ function as indicated by the laboratory values in the
             clinical protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effectiveness of Manual Therapy in Dysmenorrhea

Eligibility criteria:
Inclusion Criteria:

          -  Women with menstrual pain of more than 6 months of evolution.

          -  Women with pain equal to or greater than 4 on the visual analogue scale in more than
             half of their one-year menstrual cycles.

        Exclusion Criteria:

          -  Hormone treatment

          -  Contraindication to any of the treatments

          -  Participate in this period of no functional recovery program or physiotherapy
             treatment.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Age 16 or over.

          -  Have documentation of physician-confirmed diagnosis of moderate or severe Hemophilia A
             (severity defined as moderate = FVIII activity 1% to 5% and severe = FVIII activity
             ≤1%).

          -  Signed written informed consent provided by the patient or the patient's parents for
             patients under the age of 18 (dependent of local regulations).

          -  Signed written assent is also required for patients under the age 18 years (dependent
             on local regulations).

          -  Plan to receive at least half of their Hemophilia care at the registry site.

          -  Willing and able to enter data as per the data collection schedule.

          -  Currently receiving prophylactic or on demand treatment (including within last 6months
             for on demand).

          -  Expected life expectancy of at least 2 years.

        Exclusion Criteria:

          -  Patients with Hemophilia B

          -  Patients with von Willebrand disease (vWD)

          -  Patients with other rare bleeding disorders

          -  Unable to comply with the study protocol
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Conventional Versus Virtual Reality Based Vestibular Rehabilitation

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of peripheral vestibular dysfunction and no other neurological
             deficit (confirmed where possible with vestibular function testing; canal paresis
             >20%).

          -  One of the following subjective complaints indicating a failure of vestibular
             compensation; disequilibrium, gait instability, vertigo/dizziness, motion sensitivity.

          -  Not taking medication for vertigo or willing to discontinue with permission from
             consultant physician.

        Exclusion Criteria:

          -  Bilateral peripheral vestibular pathology.

          -  CNS involvement.

          -  Fluctuating Symptoms (Meniere's disease, migrainous vertigo) or active BPPV.

          -  Other medical conditions in the acute phase (orthopaedic injury).

          -  Previous vestibular rehabilitation.

          -  Pacemaker, Epilepsy (as per Nintendo Wii Guidelines).

          -  Unwilling or unable to use a Nintendo Wii.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Hemoglobin and INR Out of Nose Blood

Eligibility criteria:
Inclusion Criteria:

          -  Patients with active nose bleeding

          -  Indication for routine blood sampling

          -  Aged 18 to 99 years

          -  Verbal informed consent before implementation takes place

          -  Written consent of the participating person after investigation and completion of
             treatment

        Exclusion Criteria:

          -  No active bleeding

          -  Routine blood sampling for medical reasons not indicated

          -  Lack of understanding of the study or investigation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers

Eligibility criteria:
Key Inclusion Criteria:

          1. Male or female patients > 18 years of age.

          2. If female, not of childbearing potential by reason of surgery or menopause, or of
             childbearing potential, but using an approved method of contraception since the last
             menstrual period. Females of childbearing potential must have a negative serum
             pregnancy test before starting the study.

          3. Patients must report a history of heartburn at least two days per week over the past
             month.

        Key Exclusion Criteria:

          1. History of erosive esophagitis verified by endoscopy.

          2. History of gastroesophageal reflux disease (GERD) diagnosed by a physician.

          3. Patients who have a history of Barrett's esophagus or esophageal stricture.

          4. Evidence of any medical condition that may interfere with the conduct of the study,
             the interpretation of study results, or the health of the patient during the study.

          5. Patients who require continuous use of proton pump inhibitors, histamine receptor (H2)
             blockers, or prokinetics. Prior intermittent use of these agents is permitted if they
             are discontinued at least three days prior to the run-in phase. The H2 blocker,
             cimetidine (Tagamet®), must be discontinued for at least seven days before the study
             drug is administered.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Contradiction