Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: CoQ10 and Prednisone in Non-Ambulatory DMD

Eligibility criteria:
Inclusion Criteria:

          -  Age 10-18 years

          -  Non-ambulatory (primary mode of transportation is via wheelchair for 3 years or less)

          -  Confirmed DMD diagnosis

          -  Steroid-naive for the 6 months prior to screening

          -  Stable dose of b-blocker or ACE inhibitor medication for the 6 months prior to
             screening, if taking either of these medications

          -  Ability to provide reproducible repeat QMT grip score within 15% of first assessment
             score

          -  Has not participated in other therapeutic research protocol within the last 6 months
             prior to screening

          -  Ability to swallow tablets

        Exclusion Criteria:

          -  Failure to achieve one or more of the diagnostic inclusion criteria cited above

          -  Symptomatic DMD carrier

          -  Use of carnitine, other amino acids, creatine, glutamine, CoQ10 or any herbal
             medicines (this would not include herbal teas unless they are consumed daily with
             intended medicinal effect) within the last 3 months

          -  History of significant concomitant illness or significant impairment of renal or
             hepatic function, or other contraindication to steroid therapy

          -  Positive PPD

          -  No prior exposure to chickenpox and no immunization against chicken pox

          -  Baseline serum CoQ10 level of 5.0mg/ml or greater
Male
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Early Onset Alzheimer's Disease Genomic Study

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of early-onset Alzheimer's disease based on the NIA-AA diagnostic criteria
             as determined by the clinician. (Those patients with severe dementia due to
             Alzheimer's disease or who have impaired decisional capacity, may participate only if
             their legally authorized representative gives their consent.)

          -  Male and female patients ≥40 and ≤65 years of age.

          -  Parents and siblings of the participant with Alzheimer's disease.

        Exclusion Criteria:

          -  Family history of early or late-onset Alzheimer's disease.

          -  Uncontrolled concurrent illness including psychiatric illness or situations that would
             limit compliance with the study requirements or the ability to willingly give written
             or verbal informed consent
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Multidimensional Evaluation Of Daily Living Activities And Quality Of Life In Lung Cancer Patients

Eligibility criteria:
Inclusion Criteria:

          -  To have a diagnosis of lung cancer

          -  Complete chemotherapy

          -  Complete radiotherapy

          -  Coopere,

          -  Accepts participation in the study will be included in the study

        Exclusion Criteria:

          -  Neurological, cognitive or orthopedic diseases that affect the measurements

          -  Acute infection

          -  Individuals with other chronic diseases that may affect their walking will not be
             included in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)

Eligibility criteria:
Inclusion Criteria:

          -  (1) Less than 6mm endometrial thickness before, (2) at least two failed implantations
             before

        Exclusion Criteria:

          -  Abnormal uterine cavity in Hysteroscopy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Growth Hormone in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Definite/probable ALS according to El Escorial criteria

          -  Aged > 40, < 85 years

          -  Progression from onset

          -  Disease duration ≤3 years

          -  Treatment with Riluzole

        Exclusion Criteria:

          -  Rapid disease progression in the first 6 months after diagnosis

          -  Patients with tracheostomy and/or Gastrostomy

          -  Disease duration > 3 years

          -  Patient with exclusive bulbar or 2° motorneuron involvement

          -  Hepatic/renal failure

          -  Pregnant or breastfeeding

          -  Signs of active neoplasia

          -  Complicated Diabetes

          -  Severe hypertension

          -  Unable to undergo MRI exams
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Prednisolone for Pain Reduction in Knee OA

Eligibility criteria:
Inclusion Criteria:

          -  Community-dwelling older adults aged 65 years and above with primary knee OA diagnosed
             according to the ACR criteria for diagnosis of primary OA of the knee

        Exclusion Criteria:

          -  Any inflammatory or serious medical condition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease

Eligibility criteria:
Inclusion criteria:

          -  Confirmed diagnosis of gouty arthritis History of ≥ 3 gouty arthritis flares within
             the previous 12 months

          -  Confirmed diagnosis/ documented history of chronic kidney disease (CKD) Stages 3or4

          -  Onset of current acute gouty arthritis flare within 3 days prior to randomization

        Exclusion criteria:

          -  Hemodialysis CKD Stage 5 Organ transplantation

          -  Rheumatoid arthritis, evidence/suspicion of infectious/septic arthritis, or other
             acute inflammatory arthritis

          -  Live vaccinations within 3 months prior to randomization Other protocol-defined
             inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Three-dimensional Versus Two-dimensional Ultrasound Guided Embryo Transfer in Women Undergoing ART Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing embryo transfer in either fresh or frozen cycles.

          -  Women whose endometrial cavity can be visualised adequately via US

        Exclusion Criteria:

          -  Women aged >42 years

          -  Women whose endometrial cavity cannot be visualised adequately via US, such as large
             fibroids, adenomyosis, BMI>35, significant uterine retroflexion/retroversion
Female
No healthy subjects accepted to join the trial.
Subject must be at least 24 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of the Related Factors Influencing the Stability of Dental Implants

Eligibility criteria:
Inclusion Criteria:

          -  the patients who had undergone tooth extraction within the previous 3 months

        Exclusion Criteria:

          -  those who required bone augmentation simultaneously with implant insertion, and
             patients with any systemic disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Personalized Prediction of Tolerance and Immunogenicity in Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with severe or moderately severe hemophilia A (HA) who have since birth been
             treated with only a single Factor VIII product (i.e., FVIII protein molecules
             containing only one primary amino acid sequence).

        Exclusion Criteria:

          -  HA patients with severities other than severe or moderately severe.

          -  Hemophilia B patients.

          -  HA patients who have been treated with more than one FVIII product.

          -  HA patients who have been treated with more than one FVIII product.

          -  HA patients who do not have verifiable infusion histories.

          -  HA patients who lack documentable inhibitor testing & infusion histories.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: DNA Methylation Biomarkers and Metastasis of Gastric Carcinoma

Eligibility criteria:
Inclusion Criteria:

          -  Histological diagnosis of gastric adenocarcinoma;

          -  Early stage GC without lymph node and distal metastasis;

          -  Availability of frozen, fresh GC and corresponding surgical margin samples;

          -  Available of methylation status of gene CpG island in the extracted DNA sample.

        Exclusion Criteria:

          -  GC with lymph node or distal metastasis;

          -  Quality of the prepared DNA is not good enough for detection of gene methylation;

          -  GC cases were subjected to the neoadjuvant chemotherapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment