Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Radiological Analysis on Patients With Achondroplasia Disorder

Eligibility criteria:
Inclusion Criteria:

          -  Boys and girls.

          -  Aged from 0 to 18 years old.

          -  Subjects with an Achondroplasia diagnosis.

          -  Patients or parents/ legal guardian must provide non opposition prior to participation
             in the study.

        Exclusion Criteria:

        - Patients or patient's parents or legal guardian whose have an objection for using their
        data.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Clinical Study to Assess the Efficacy and Safety of Amizon® Max in the Treatment of Moderate Covid-19

Eligibility criteria:
Inclusion Criteria:

        Each subject must meet all of the following inclusion criteria to be randomized to
        treatment:

          1. Willing and able to provide written informed consent

          2. Aged ≥ 18 years

          3. SARS-CoV-2 infection confirmed by PCR ≤ 4 days before randomization

          4. Currently hospitalized due to SARS-CoV-2 infection with fever, defined as body
             temperature ≥ 37.8 °C

          5. Modified World Health Organization (WHO) Ordinal Scale for Clinical Status Patient
             state in Covid-19: score 4 i.e. hospitalized, virus-positive, oxygen by mask or nasal
             prongs

        Exclusion Criteria:

        The subject is excluded from the trial if any of the following criteria apply:

          1. Concurrent treatment with other agents with actual or possible direct acting antiviral
             activity against SARS-CoV-2 is prohibited < 24 hours prior to start of IMP treatment

          2. Requiring mechanical ventilation at screening or it is expected within 24 h after
             inclusion

          3. Expected survival time < 72 hours for any reason

          4. Positive pregnancy test

          5. Breastfeeding woman

          6. Presence of renal dysfunction defined as estimated glomerular filtration rate (eGFR)
             <60 mL/min, total bilirubin ≥ 2.0 mg/dL, Thyroid stimulating hormone (TSH) outside
             normal range and / or Aspartate aminotransferase (ASAT)/ Alanine aminotransferase
             (ALAT) above threefold upper limit of normal range (known from patients medical
             history)

          7. Known hypersensitivity to the trial drug, the metabolites, or formulation excipient

          8. History or presence of drug or alcohol abuse

          9. History or presence of diseases of thyroid gland
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Evaluation of the Effectiveness of Internet Based Nutrition and Physical Activity Education Programme in Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  All students who accept to participate in the study

        Exclusion Criteria:

          -  Students who refused to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          1. Older than 55-year-old，male or female.

          2. patients meet the diagnosis of mild cognitive impairment (MCI) or Alzheimer's
             disease(AD) or whose family members were diagnoed with AD

          3. Complete self-rating scale for memory impairment (AD-8 scale)

          4. Those who agree to participate in clinical research and sign informed consent.

        Exclusion Criteria:

          1. Patients with acute cardiovascular and cerebrovascular diseases, acute infections
             (pneumonia, urinary tract infection, oral infection, digestive tract infection),
             severe renal dysfunction, and uremia;

          2. Pregnant or lactating women;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A Pilot Randomized Controlled Trial for Hand Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Enrolled to receive medical care at the Michael E. DeBakey VA Medical Center

          -  At least 3 joints affected by distal interphalangeal (DIP) nodal hand OA

          -  DIP nodal hand OA will be defined as Heberden's nodes on physical exam.

          -  Sufficiently severe frequent pain of at least one DIP

          -  Frequent pain: pain on most days of the month for at least one month in the last year.

          -  Minimum VAS pain severity of 40 on a 0 - 100 scale

        Exclusion Criteria:

          -  History or current inflammatory arthritides (examples: gout, psoriatic arthritis, and
             rheumatoid arthritis)

          -  Prior surgery on the DIP joints

          -  Planned surgery for the DIP joints

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Evaluation of Body Iron Stores in Overweight Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Male,

          -  At least 18 years old

          -  BMI > 25 Kg/m2

          -  Serum ferritin level between 100 et 300 µg/L

          -  Written informed consent

        Exclusion Criteria:

          -  Blood donations in the past two years

          -  Alcohol consumption more than 30 g/day

          -  Inflammatory syndrome (CRP > 10 mg/L)

          -  Inflammatory, dysimmunitary or cancerous disease

          -  Hepatic cytolysis

          -  Transferrin saturation > 45%

          -  Person involved in another clinical trial

          -  Person with a measure of legal protection (guardianship)

          -  Person who reached the annual limit for compensation provided by biomedical research

          -  Hemoglobin < 13 g/dL

          -  Uncontrolled heart failure or coronary insufficiency

          -  Abnormal ECG

          -  Echocardiographic abnormalities contraindicating phlebotomy

          -  Hepatic, renal or respiratory insufficiency

          -  Superficial venous network insufficiency
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Feasibility of a Water-soluble Contrast Application Into Dysphagia Evaluation

Eligibility criteria:
Inclusion Criteria:

          -  All the patients who referred for video-fluoroscopic-swallowing study

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Special Survey for Long Term Application

Eligibility criteria:
Inclusion Criteria:

          -  Achondroplasia without epiphyseal line closure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 15 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Efficacy and Safety of Sirolimus in COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          -  Adults (˃18 years) COVID-19 positive patients (confirmed by PCR).

          -  Moderate infection ( pneumonia ± leucopenia or lymphopenia ).

        Exclusion Criteria:

          -  Severe or life threatening COVID infection: Severe disease is defined as: dyspnea,
             respiratory frequency ≥ 30/min, blood oxygen saturation ≤ 93%, partial pressure of
             arterial oxygen to fraction of inspired oxygen ratio < 300, and/or lung infiltrates >
             50% within 24 to 48 hours. Life threatening disease is defined as: respiratory
             failure, septic shock, and/or multiple organ dysfunction or failure .

          -  Pregnant or lactating females.

          -  Participation in any investigational clinical study, other than observational, within
             the past 30 days; or plans to participate in such a study at any time from the day of
             enrollment until 30 days post-treatment in the current study.

          -  Allergy or hypersensitivity to sirolimus.

          -  Taking immunosuppressive drugs.

          -  Glomerular filtration rate (GFR) < 30 ml/min by CKD-EPI equation.

          -  liver cirrhosis .

          -  Decompensated heart failure.

          -  known active tuberculosis (TB) or history of incompletely treated TB.

          -  Uncontrolled systemic bacterial or fungal infections.

          -  Drugs that may affect sirolimus level: antifungals, diltiazem, verapamil, nicardipine,
             phenytoin, phenobarbital, rifampicin, carbamazepine.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Effect of Woodsmoke on Vascular Function

Eligibility criteria:
Inclusion Criteria:

          -  Non-smoking healthy male firefighters or volunteers

        Exclusion Criteria:

          -  Current smoker or regular users of snus

          -  History of lung or ischaemic heart disease

          -  Malignant arrhythmia

          -  Systolic blood pressure >190mmHg or <100mmHg

          -  Renal or hepatic dysfunction

          -  Previous history of blood dyscrasia

          -  Unable to tolerate the supine position

          -  Blood donation within the last 3 months

          -  Recent respiratory tract infection within the past 4 weeks

          -  Routine medication including aspirin and NSAIDs
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction