Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Cementation Techniques for Single-tooth Implant Crowns

Eligibility criteria:
Inclusion Criteria:

          -  completed growth and development

          -  periodontally and dentally healthy conditions

          -  missing single molar tooth without free-end edentulism

          -  bone-level standard diameter of a specific implant from one manufacturer

          -  complication free healing period for osseointegration following straightforward
             surgical implant placement

          -  natural dentition or fixed restoration in dental arch

          -  signing of informed consent form

        Exclusion Criteria:

          -  absolute systemic contraindications for implant surgery (e.g. bone cancer, radiation
             therapy)

          -  relative systemic contraindications for implant surgery (e.g. diabetes, steroid
             therapy)

          -  risk factors (e.g. smoking, limited mouth opening)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Evaluation of Endometrial Stromal Cell Apoptosis in Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  women with adenomyosis

          -  at early- to mid-secretory phases

        Exclusion Criteria:

          -  postmenopausal

          -  malignancy
Female
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Effect of Dietary Fiber on Metabolism, Inflammation and Nutritional Status in Patients With Chronic Diseases

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-70y

          -  Be diagnosed with obesity, hyperlipemia or hyperglycemia

          -  Fully understood and voluntarily signed the informed consent

        Exclusion Criteria:

          -  Secondary hyperlipidemia or hyperglycemia

          -  Multiple organ failure

          -  Allergic or intolerant to dietary fiber(dietary supplement)

          -  Have gastrointestinal diseases

          -  Have a history of abdominal diseases

          -  Experienced intra-abdominal surgery

          -  Pregnant and lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Effect of Testosterone Replacement in Patients With Hypogonadotrophic Hypogonadism Due to Opioid Treatment for Non-malignant Disease

Eligibility criteria:
Inclusion Criteria:

          -  Male patients 18-75 years

          -  Treatment with opioid for >3 months, daily dose >50-100 mg

          -  Total testosterone < 12 mmol/L

          -  Follicle Stimulating Hormone (FSH)/Luteinizing Hormone (LH) levels normal og below
             normal laboratory values

          -  Normal prolactin levels

        Exclusion Criteria:

          -  Hematocrit> 54% at screening

          -  Prostate Specific Antigen (PSA) > 3 ng/ml

          -  Severe organic and mental disease

          -  current or present cancer diagnosis

          -  Previous venous thrombotic embolism and cerebrovascular disease

          -  Uncontrolled hypertension

          -  Epilepsy or migraine not adequately controlled by therapy

          -  Severe benign prostate hypertrophy with symptom score >19

          -  Sleep apnea

          -  Alcohol or drug abuse

          -  Implantation of sustained action sex hormone in the last 12 months

          -  Use of oral, buccal or transdermal testosterone in the last two weeks

          -  Treatment with glucocorticoids > 5 mg/day or 5 alfa reductase inhibitors

          -  Hypersensitivity to Nebido
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Human Movement Database

Eligibility criteria:
-  Any volunteer of any age from birth to old age who is deemed medically fit to
             participate and is willing to provide their informed consent will be included in the
             study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Month old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Severe haemophilia A (FVIII < 1 IU/dl)

          -  Currently on prophylactic therapy

          -  The same prophylaxis regimen in the last six months

          -  Age: 2 (with a body weight ≥12.5 kg ) - 45 years

          -  Adequate venous access

          -  Haemophilia patient's diary or equivalent regularly completed

          -  Ability of patient or family (for minors) to give informed consent

          -  Subject with health insurance

        Exclusion Criteria:

          -  Age <2 and >45 years

          -  Haemophilia A with documented inhibitor in the last 12 months

          -  Clinically symptomatic liver disease (historical evidence documented in patient's
             medical file)

          -  Platelet count < 100x109/l

          -  Poor venous access

          -  Presence of a documented target joint

          -  Subject under legal protection measure.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who are ≥ 45 years old

          -  Symptomatic knee OA defined as symptoms of knee pain and/or decreased range of motion
             (ROM)

          -  Classified radiographically as having Grade 2 or 3 Knee OA

          -  Failure of 3-months conservative management (NSAIDs and Physical therapy)

        Exclusion Criteria:

          -  Patients < 45 years old

          -  Pregnant or breastfeeding women

          -  Cancer patients

          -  Rheumatoid arthritis patients

          -  Patients having any autoimmune disease affecting the joint

          -  Patients who have had hyaluronic acid injection <1 year ago

          -  Patients who have undergone lower extremity surgery or trauma on the same side

          -  Hypersensitivity to methylprednisolone (Depo-Medrol®)or any of its components,
             lidocaine/xylocaine or any of its components, and any of the ingredients of Lipogems®
             injection kit

          -  Patients with acute systemic or local infection

          -  Patients on anticoagulants (warfarin, coumadin, heparin, Xeralto, or Plavix)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Thoracic Ultrasound in the Treatment of Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Patients hospitalized or seen in consultation with pleural effusion diagnosed
             clinically or radiologically whatever be its initial management.

        Exclusion Criteria:

          -  Patient with a neoplasia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Rhythmical Massage Compared With Heart Rate Variability Biofeedback in Women With Menstrual Pain (Dysmenorrhea)

Eligibility criteria:
Inclusion Criteria:

          -  At least one year of primary dysmenorrhea (physician-confirmed).

          -  Written informed consent (also from parents/legal guardians of underage girls).

          -  Menarche at least one year ago.

        Exclusion Criteria:

          -  Secondary dysmenorrhea.

          -  Participation in another study.

          -  Mental retardation.

          -  Addiction.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 46 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence

Eligibility criteria:
Inclusion Criteria:

          -  following a diagnostic of chronic sleep disorders responsible to hypersomnolence with
             a score at the Epworth scale better than 10/24

          -  can be treated or not for chronic sleep disorder.

          -  speak and understand french

          -  should have a social security system

          -  should not have infectious or inflammatory pathology

        Exclusion Criteria:

          -  be private of liberty

          -  live in medical institution

          -  be a major protected by law

          -  not have social security system

          -  refuse to participate in protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: IL-11 in Women With Von Willebrand Disease and Refractory Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Females 18-45 years of age

          -  Confirmed type 1 VWD, as defined by low VWF:RCoF or low VWF:Ag and qualitatively
             normal VWF multimers

          -  Menorrhagia refractory to estrogens, hormones, hemostatic agents

          -  Willingness to have blood drawn

        Exclusion Criteria:

          -  Use of immunomodulatory or experimental drugs, or diuretics

          -  Pregnant or lactating women or those unwilling to use contraception during study

          -  Previous cardiac disease, congestive failure, arrhythmia (e.g., atrial fibrillation,
             atrial flutter), hypertension, MI, stroke, or thrombosis

          -  Past allergic reaction to Neumega or DDAVP

          -  Surgery within the past 8 weeks

          -  Inability to comply with study protocol requirements

          -  Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin or NSAIDs

          -  Treatment with DDAVP, cryoprecipitate, whole blood, plasma and plasma derivatives
             containing substantial quantities of FVIII and/or VWF within five days of study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment