Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Basal Joint Arthritis Prospective

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have symptomatic basal joint arthritis.

          -  Patients who are capable of providing informed consent

        Exclusion Criteria:

          -  Patients younger than 18 years old at the time of enrollment

          -  Patients with neuromuscular disease affecting the operated hand, not caused by the CMC
             operation

          -  Patients with known inflammatory arthritic conditions, such as rheumatoid or psoriatic
             arthritis

          -  Patients with a history of or current infection of the basal joint of the affected
             hand.

          -  Patients who are demented or are unable to provide informed consent.

          -  Patients unable to comply with study guidelines.

          -  Patients who have metacarpophalangeal joint hyperextension are NOT excluded. These
             patients will be followed and if they receive a capsulodesis or other procedure at the
             MCPJ at the same time as their basal joint arthroplasty this will be noted in their
             data records.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee

Eligibility criteria:
Inclusion criteria:

          -  Subjects diagnosed with primary Osteoarthritis of the knee.

          -  Have at least 3 months in symptom duration prior to screening visit.

          -  Regular user of a prescribed non-steroidal anti-inflammatory drug (NSAID) or selective
             cyclo-oxygenase II (COX2) inhibitor for management of knee pain.

          -  Pain walking on flat surface within specific interval prior to study start.

        Exclusion criteria:

          -  History of hypersensitivity to NSAIDS.

          -  Allergy to Ibuprofen.

          -  Use of assistive devices other than a cane or knee brace.

          -  History of specified diseases/illnesses.

          -  Abnormal blood tests pre-study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine

Eligibility criteria:
Inclusion Criteria:

          -  Subjects scheduled for laparoscopic unilateral inguinal hernia repair

          -  ASA 1 or2.

          -  Age >18 years.

        Exclusion Criteria:

          -  Pregnancy or lactating

          -  Allergy to NAC

          -  History of chronic pain

          -  Use of opioids or neuropathic analgesics

          -  Use of NAC prior to trial (< 1 month of planned surgery)

          -  Alcoholism

          -  Diabetes Mellitus (insulin therapy)

          -  Asthma or Chronic Obstructive pulmonary Disease

          -  Known renal function disorders (MDRD <ô0)

          -  Known liver failure (bilirubin >1.Sx upper limit of normal)

          -  No written lC by patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Clinical Trial of Low Dose Oral Interferon Alpha in Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  The only subjects to be included in this study are those diagnosed with Idiopathic
             Pulmonary Fibrosis with diagnosis based on the criteria published by the American
             Thoracic Society in the International Consensus Statement.

               1. Exclusion of other known causes of interstitial lung disease.

               2. Abnormal pulmonary function studies.

               3. Bibasilar reticular abnormalities with minimal ground glass opacities on HRCT
                  scan.

               4. Biopsy or lavage showing no features supporting alternative diagnosis.

               5. Patient older than 50 years of age.

               6. Insidious onset of otherwise unexplained dyspnea on exertion.

               7. Duration greater than 3 months.

               8. Bibasilar, inspiratory crackles.

        Exclusion Criteria:

          -  under the age of 50

          -  history of hypersensitivity to interferons

          -  history of hypersensitivity to biological products such as vaccines

          -  pregnant or lactating women

          -  women of child bearing age not pregnancy protected during the study

          -  unresolved serious cardiovascular disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A 21 Day Pharmacokinetics Study in Papulopustular Rosacea

Eligibility criteria:
Inclusion Criteria:

          -  A diagnosis of papulopustular rosacea

          -  Grade 3 or 4 on the 5-point Investigator Global Assessment scale

          -  Presence of telangiectasia

        Exclusion Criteria:

          -  steroid rosacea or subtype 3 (phymatous rosacea)

          -  clinically significant abnormal findings that would interfere with study objective or
             risk to safety for the subject.

          -  nodular rosacea (lesions greater than 5mm with more than 2 modules)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Prognostic Factors in Patients Admitted to an Urban Teaching Hospital With COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          -  Clinical, radiological and PCR positive COVID-19 diagnosis

        Exclusion Criteria:

          -  less than 18 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Gastro-intestinal Tumors

Eligibility criteria:
Inclusion Criteria:

          -  In principle, all patients treated for gastrointestinal tumors will be included (only
             with the permission (informed consent) of the patient)

        Exclusion Criteria:

          -  In case of a known contraindication for MRI (eg pacemaker), the patient will not be
             admitted to the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          1. Heartburn on at least 2 days of the past 7 days prior to screening, with or without a
             history of EE or a documented diagnosis of GERD within 6 months prior to screening,
             with or without a history of EE.

          2. Body mass index (BMI) of ≥18.5 and ≤35 kg/m2. [BMI will be calculated using the
             following formula: weight (kg)/height (m)2.]

          3. Able to communicate with the investigator and to understand and comply with the
             requirements of the study.

        Exclusion Criteria:

          1. History of esophageal, gastric, or duodenal surgery, except for simple closure of an
             ulcer.

          2. History of severe liver disease, including (but not limited to) cirrhosis and acute or
             chronic hepatitis.

          3. Any significant "alarm symptoms", within the past 6 months, such as, unintentional
             weight loss, gastrointestinal bleeding, jaundice or any other sign indicating serious
             or malignant disease.

          4. Abnormal lab test results, as indicated in the protocol.

          5. Other diseases, as indicated in the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Platelet-Rich Protein and the Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing a frozen thawed embryo transfer cycle with poor endometrial response
             to estrogen (< 7 mm) after at least two standard preparation protocols, of which one
             was canceled due to thin endometrium

        Exclusion Criteria:

          -  none
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 54 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Ultrasound Abnormalities of the Salivary Glands in Primary Sjögren's Syndrome According to the Duration of the Disease

Eligibility criteria:
Inclusion Criteria:

          -  Male or female patient ≥ 18 years

          -  Primary sjögren syndrome according of age to 2002 or 2016 classification criteria

        Exclusion Criteria:

          -  Secondary sjögren syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment