Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Phase II Study of IL-11 (Neumega) in Von Willebrand Disease

Eligibility criteria:
Inclusion Criteria:

          -  Males and females 18 years of age or older

          -  Confirmed VWD by 2 of 4 VWD coagulation tests abnormal

          -  A past bleeding history

          -  No hormone, oral contraceptive, estrogen use in past 8 weeks

          -  Willingness to have blood drawn

          -  Willingness to sign informed consent

        Exclusion Criteria:

          -  Presence of other bleeding disorder, e.g. acquired VWD, thrombocytopenia

          -  Use of estrogens, hormones, oral contraceptives in past 8 weeks

          -  Use of immunomodulatory or experimental drugs or diuretics

          -  Pregnant or lactating women

          -  Past cardiac disease, congestive failure, arrhythmia (e.g. atrial fibrillation, atrial
             flutter), hypertension, MI, stroke, or thrombosis

          -  Past allergic reaction to Neumega or DDAVP

          -  Surgery within the past 8 weeks

          -  Inability to comply with study protocol requirements

          -  Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin, or NSAIDs

          -  Treatment with DDAVP, cryoprecipitate, whole blood, plasma, and plasma derivatives
             containing FVIII, VWF within 5 days of study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Post-void Bladder Scanning in Acute Cauda Equina Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Patients with suspected CES

          -  Minimum age 18 years.

          -  Both sexes

          -  Able to provide informed consent for their data to be included in the study

        Exclusion Criteria:

          -  Patients with pre-existing urinary tract pathologies (neuropathic bladder, urologic
             pathologies or surgery, history of urinary incontinence.)

          -  Under age of 18 years.

          -  Patients with urinary catheter for whatever reason.

          -  Prisoners.

          -  Patients unable to provide informed consent for themselves.

          -  Previous spinal surgery

          -  Patients with urinary tract infections

          -  Patients with pre-existing neurological conditions affecting:

          -  Central nervous system such as multiple sclerosis

          -  Peripheral nervous system such as diabetic neuropathy, B12 deficiencies, thyroid
             abnormalities

          -  Autonomic nervous system such as multiple system atrophy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Changes in Bleeding and Clotting During the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Must be female

          -  Aged 18 to 50 years, with regular menstrual cycles.

          -  Healthy volunteers and women with von Willebrand's disorder are both being recruited.

        Exclusion Criteria:

          -  Pregnancy

          -  Use of hormonal therapy including birth control pills

          -  Use of hemostatic agents such as DDAVP or anti-platelet agents.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?

Eligibility criteria:
Inclusion Criteria:

          -  Participant has been implanted with the DBS for ET

          -  Participant has significant voice tremor as determined by our
             laryngology/speech-language pathology team

        Exclusion Criteria:

          -  Participant does not have history of aphasia or other speech/language deficits

          -  Participant does not have history of stroke or multiple sclerosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effects of FRAX+SARC-F Pre-screening on Preventing Fragility Fracture and Fall in Community-dwelling Older Adults

Eligibility criteria:
Inclusion Criteria:

          -  aged ≥ 65

          -  Functional Ambulation Category (FAC) score ≥ 3

          -  able to walk for ≥ 10 meters

          -  living in the community

          -  Montreal Cognitive Assessment-5-minute protocol score ≥ the 16th percentile of the age
             and education adjusted cutoff score (i.e., being cognitively intact)

          -  can communicate effectively in Cantonese.

        Exclusion Criteria:

          -  on prescription anti-osteoporotic medications

          -  have uncorrected vision or hearing impairment

          -  have an unstable condition or terminal disease that is unlikely to resolve and may
             preclude the planned assessments (e.g. malignant arrhythmias).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Study to Evaluate Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ASC42 in Healthy Subjects

Eligibility criteria:
Key Inclusion Criteria:

          -  Healthy male and female subjects between 18 to 65 years of age.

          -  Subjects' weight ≥ 50 kg and BMI within the range of 19 - 29 kg/m2.

          -  Physical examination and vital signs are within normal range or slightly abnormal.

        Key Exclusion Criteria:

          -  History or current liver disease, or liver injuries.

          -  A positive HBsAg, HCV Ab and/or HIV Ab.

          -  Platelet count <150,000/mcL

          -  INR> 1.2
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Use of Facebook as a Motivating Factor in a Weight-reduction Program for Obese and Overweight Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  Adolescents between 13 and 19 years old.

          -  Obese or overweight according to the IOTF.

          -  No physical or medical impediment for performing physical activity.

          -  No risk for eating disorders (SCOFF questionnaire).

          -  Report less than 20 minutes of physical activity per day.

          -  Have an active Facebook account and use it more than 20 minutes per day.

          -  Low-risk in the Gatehouse Bullying Scale.

        Exclusion Criteria:

          -  Physical or medical impediment for performing physical activity.

          -  Answer "yes" at least twice on the SCOFF questionnaire.

          -  Report more than 20 minutes of exercise per day.

          -  Not having an active Facebook account or using it less than 20 minutes per day.

          -  "High Risk" on the Gatehouse Bullying Scale.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 19 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Validity, Reliability and Responsiveness of the Fullerton Advanced Balance Scale in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Individuals diagnosed with knee osteoarthritis II-III level according to the results
             of radiological evaluation by Kellgren and Lawrence

          -  Individuals aged between 40 and 65 years

          -  Individuals who have pain in his/her either of the knees in 3 month period and who
             have a VAS score of 3 or more

          -  Individuals who can walk 10 meters independently (with or without ancillary device)

        Exclusion Criteria:

          -  Individuals with Body Mass Index 35 and above

          -  Individuals with a history of surgery or injury involving the lower limb within the
             last 1 year (knee / hip endoprosthesis, post-fracture surgery, menisectomy, etc.)

          -  Individuals who received hyaluronic acid or corticosteroid injections in the last year

          -  People with severe eyesight, hearing disabilities Individuals with neurological
             deficit or disorder

          -  Individuals with regular exercise habits in the last 6 months

          -  Individuals with inflammatory rheumatic diseases.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Convalescent Plasma vs Human Immunoglobulin to Treat COVID-19 Pneumonia

Eligibility criteria:
Inclusion Criteria:

          -  Patients who are admitted to Hospital Centers with a positive RT-qPCR SARS-CoV-2 test
             or a CT scan compatible with a diagnosis of COVID-19 pneumonia, in addition to one of
             the following two criteria:

               1. Severe respiratory failure [respiratory rate> 25 - <35 x minute, oxygen
                  saturation ≤ 90% with reservoir mask (FiO2 = 100%)]

               2. Requiring invasive mechanical ventilation.

        Exclusion Criteria:

          -  Patients with a viral infection other than COVID-19
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: The ASSESS National Multi-center Prospective Cohort

Eligibility criteria:
Inclusion Criteria:

          -  aged of 18 years or more

          -  Primary Sjögren's Syndrome Patients who have already participated to the study ASSESS

        Exclusion Criteria:

          -  secondary Sjögren's Syndrome (SJ) associated with other autoimmune diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment