Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: EEG Characteristics in Youth POTS and/or Syncope

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 9-21 years

          -  Referred to the neurology POTS and Syncope clinic at Nationwide Children's Hospital
             for clinical tilt table testing

          -  Has prior diagnosis or signs/symptoms of POTS (with or without syncope) or syncope
             (without POTS)

        Exclusion Criteria:

          -  Cognitive, somatic or psychiatric illness that precludes tilt table testing, prolonged
             standing, or EEG lead placement

          -  Known seizure disorder

          -  Scalp or skull defect that could affect EEG amplitudes

          -  Pregnancy

          -  Non-English speaking
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 9 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Endometrial Injury in Couples With Unexplained Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained infertility ( 1ry & 2ndry infertility) : *

               -  Normal hormonal profile of infertile woman.

               -  Normal hystrosalpingogram.

               -  Normal laparoscopy.

               -  Normal investigation of the cervical factor

               -  Fertile semen analysis (according to world health organization criteria 2015).

        Exclusion Criteria:

          -  • Infertile semen analysis.

               -  Abnormal HSG.

               -  Abnormal laparoscopic findings.

               -  Disturbed hormonal profile.

               -  Evidence of cervical factor.

               -  Known genetic disorder

               -  Known autoimmune disease
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 36 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Assessment of Ovarian Reserve After Laparoscopic Cystectomy Versus Aspiration/Electrocoagulation in the Treatment of Ovarian Endometrioma

Eligibility criteria:
Inclusion Criteria:

          -  Female with age between 18-40 years.

          -  Regular menstrual cycles

          -  Female diagnosed by ultrasound with unilateral ovarian endometrioma ≥4cm and ≤6cm.

        Exclusion Criteria:

          -  Hormone, Gonadotropin-releasing hormone analogues or contraceptive therapy within 6
             months before the current surgery and 6 months after surgery.

          -  Suspected or proven ovarian malignancy.

          -  Previous ovarian surgery.

          -  Evidence of polycystic ovary syndrome.

          -  Evidence of premature ovarian failure or premature menopause.

          -  Endocrinological diseases affecting ovarian reserve e.g. Diabetes mellitus,
             hypothyroidism.

          -  Pregnancy test is positive.

          -  Lactation.

          -  Unable or unwilling to give written consent.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years

Eligibility criteria:
Inclusion Criteria:

          -  Young girls with turner syndrome proved by karyotype

          -  Growth hormone secretion confirmed with ornithin stimulation test

          -  Normal glucidic metabolism confirmed by assessment of HbA1c

          -  None associated severe pathology which could have impact on growth (i.e. renal
             insufficiency, decompensated heart failure)

          -  No previous or associated treatment with anabolic or sexual steroids

          -  Known parental height

        Exclusion Criteria:

          -  Severe associated pathology with impact on growth

          -  Concomitant treatment with impact on growth

          -  Previous or associated treatment with anabolic steroids

          -  Associated growth hormone deficiency
Female
No healthy subjects accepted to join the trial.

Subject must be at most 4 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain

Eligibility criteria:
Inclusion Criteria:

          -  Age: greater than 18 years

          -  Weight: less than 300 lbs.

          -  Diagnosis: osteoarthritis

          -  Type of Surgery: unilateral knee replacement

        Exclusion Criteria:

          -  No pacemaker or defibrillator.

          -  No infection of the affected knee.

          -  No previous open surgery of the affected knee.

          -  No history of Rheumatoid Arthritis.

          -  No more than 2 narcotic pills per month in the last 6 months for pain.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: ASC618 Gene Therapy in Hemophilia A Patients

Eligibility criteria:
Inclusion Criteria:

          -  Male ≥18 years of age

          -  Severe or moderately severe hemophilia A (FVIII activity ≤ 2 IU/dL) as evidenced by

          -  medical history

          -  Received FVIII prophylactic or on-demand replacement therapy for ≥ 150 accumulated

          -  days (exposure days)

          -  ≥12 bleeding episodes if receiving on-demand therapy over the preceding 12 months

          -  BMI ≤ 30

          -  Agree to use double-barrier contraceptive until at least 3 consecutive semen samples
             are negative after ASC-618 infusion

        Exclusion Criteria:

          -  Pre-existing immunity to AAV8 vector as defined by AAV8 total antibodies and
             neutralizing antibodies qualified tests.

          -  Current inhibitors, or history of high titer FVIII inhibitors

          -  Presence of > Grade 2 liver fibrosis on elastography/Fibroscan or comparable imaging
             methodology

          -  History of chronic renal disease

          -  Active infection or any immunosuppressive disorder

          -  History of cardiac surgery and need anticoagulant therapy

          -  Any cardiovascular / genetic risk factors for thromboembolic disorders

          -  Evidence of active Hepatitis B, Hepatitis C, Human Immunodeficiency Virus (HIV)-1/2 or
             syphilis infection.

          -  Receipt of any vector or gene transfer agent

          -  Current antiviral therapy for hepatitis B or C
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of Bleeding Score in Egyptian Patients With vWD Type I and Correlate it With Laboratory Parameters

Eligibility criteria:
Inclusion Criteria:

          -  type 1 vWD patients

          -  healthy subjects with no known problem with bleeding or bruising were also recruited

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Predictive Value of Complement C3 in Patients With Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Pathological diagnosis of gastric adenocarcinoma

          -  Radical operation and adjuvant chemotherapy endurable

          -  Informed consent approved

        Exclusion Criteria:

          -  Age <18 or >75 years old

          -  Pregnancy or lactating woman

          -  Any primary diagnosis other than gastric cancer

          -  Confirmed complement deficiency due to immunity dysfunction or other disease

          -  Required blood transfusion, plasmapheresis, or emergent operation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effects of Tranexemic Acid Versus Norethisterone Acetate on Endometrial Vasculature .

Eligibility criteria:
Inclusion Criteria:

          -  Age: 35-49 years old.

          -  Normal gynecologic and breast examination

          -  Women who have sterilization or husband is sterilized or accepts to use a suitable
             barrier contraception during the duration of the study.

          -  Heavy periods (were assessed by validated pictorial blood chart)

          -  Normal ultrasound, hysteroscopy and endometrial biopsy.

          -  Normal coagulation profile and thyroid function.

          -  No contraindication to tranexamic acid or Norethisterone acetate : allergy,History of
             arterial or venous thromboembolic disease,Disturbance of liver function or Severe
             renal impairment.

        Exclusion Criteria:

          -  Women who are less than 35 years old or more than 49 years old.

          -  Women who had organic cause for heavy periods as uterine polypi,fibroids or
             endometriosis.

          -  Women taking hormonal preparation the month before starting the trial.

          -  Women with abnormal findings in pelvic ultrasound,hysteroscopy or endometrial biopsy.

          -  Women who suffer from uncontrolled diabetes or uncontrolled hypertension.

          -  Women with history of breast cancer or precancerous conditions.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results

Eligibility criteria:
Inclusion Criteria:

          -  Age 30-75 years

          -  Men

          -  Primary inguinal hernia

          -  ASA I-III

        Exclusion Criteria:

          -  > 75 years

          -  Females

          -  ASA IV

          -  Previous ipsi-lateral hernia surgery

          -  Drug or alchol abuse

          -  Severe illness
Male
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Magnetic Resonance Imaging in Subjects With Gouty Tophi

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with gout and at least one tophi.

        Exclusion Criteria:

          -  Unable to undergo MRI.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction