Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Clinical Trial of Several Contact Lenses in Extended Wear

Eligibility criteria:
Inclusion Criteria:

          -  Be of legal age, and be between 18 and 39 years of age.

          -  Signed Written Informed Consent and Investigator to record this on Case Report Form
             (CRF) in appropriate space.

          -  Require a visual correction in both eyes (Monovision not allowed)

          -  Require a soft contact lens spherical correction between -0.50 and -9.00D.

          -  Have an astigmatic correction less than 1.50D in both eyes.

          -  Be able to wear the lens powers available for this study.

          -  Be able to regularly wear the lenses on a 7 day/6 night extended wear basis (e.g. does
             not regularly swim more than once a week)

          -  Be correctable to a visual acuity of 20/30 or better in each eye.

          -  Have normal eyes with no evidence of abnormality or disease. For the purposes of this
             study a normal eye is defined as one having:

          -  No amblyopia.

          -  No evidence of lid abnormality or infection.

          -  No clinically significant slit lamp findings

          -  No other active ocular disease.

          -  No previous ocular surgery.

        Exclusion Criteria:

          -  Requires concurrent ocular medication.

          -  Any systemic illness which would contraindicate lens wear or the medical treatment of
             which would affect vision or successful lens wear.

          -  No Clinically significant (Grade 3 or 4) slit lamp findings including corneal edema,
             corneal vascularization, corneal staining, tarsal abnormalities, bulbar injection, or
             any other abnormality of the cornea that would contraindicate contact lens wear.

          -  Diabetic.

          -  Infectious disease (e.g., hepatitis, tuberculosis) or an immunosuppressive disease
             (e.g., HIV).

          -  PMMA or RGP lens wear in the previous 8 weeks.

          -  Has had refractive surgery. Has had eye injury/surgery within 8 weeks immediately
             prior to enrolment for this study.

          -  Abnormal lacrimal secretions.

          -  Pre-existing ocular irritation that would preclude contact lens fitting.

          -  Keratoconus or other corneal irregularity.

          -  Pregnancy, lactating or planning a pregnancy at the time of enrollment only.

          -  Participation in any concurrent clinical trial.

          -  Currently wearing B&L PureVision, Ciba O2 Optix, Ciba Night & Day, CooperVision
             Biofinity, Vistakon ACUVUE® OASYS, or Vistakon ACUVUE®2 on an EW basis

          -  Has had previous adverse event(s) contraindicating EW e.g. MK or greater than 2
             corneal scars which appear to be contact lens related (e.g. not trauma related).

          -  Has had an eye injury or surgery within the last eight weeks.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Entailment