Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Eligibility criteria:
-INCLUSION CRITERIA:

          1. An individual, or their family members, with any of the following:

               -  Fulfills clinical criteria for Hereditary Diffuse Gastric Cancer (HGDC) syndrome
                  or Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) syndrome

               -  Clinically suspicious personal or family medical history of gastric cancer or
                  gastric cancer syndrome that warrants genetics evaluation

               -  Current diagnosis of gastric cancer and a germline mutation associated with a
                  known cancer syndrome or an associated family history of gastric cancer

               -  Harbors a pathogenic germline mutation known to predispose to gastric cancer

               -  First-degree relatives, regardless of family history or personal history of
                  cancer, with a documented deleterious germline mutation (including but not
                  limited to CDH1, CTNNA1, SDH) known to predispose to gastric tumors

               -  Diagnosis or suspicion of a premalignant or malignant stomach lesion of suspected
                  hereditary etiology

          2. Age greater than or equal to 18 years; patients under 18 years of age and greater than
             or equal to the age of 2 may participate if the tissue acquisition is performed during
             a clinically indicated surgical procedure, and the sampling of tissue, blood and urine
             collection does not add risk to the clinically indicated procedures.

          3. Ability of subject or legally authorized representative (LAR) to understand and the
             willingness to sign a written informed consent document.

        EXCLUSION CRITERIA:

        -None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Sensory Memory in Speech Motor Learning

Eligibility criteria:
Inclusion Criteria:

          -  right handed adults

          -  no known physical or neurological abnormalities

        Exclusion Criteria:

          -  patients with:

          -  cardiac pacemaker

          -  surgical clips or values on the heart

          -  implants

          -  metal or metallic fragments in any part of the body

          -  pregnancy

          -  claustrophobia

          -  a personal or family history of epilepsy

          -  currently taking antipsychotic drugs

          -  currently taking antidepressant drugs

          -  currently taking antianxiety drugs

          -  history of concussion.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Thrombosis and Covid-19

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Covid-19

          -  non-opposition of the patient to participate

        Exclusion Criteria:

          -  Non-Covid-19 acute respiratory distress syndrome

          -  Non-Covid septicemia

          -  Pregnant women

          -  Breastfeeding women

          -  Protected vulnerable adults
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children

Eligibility criteria:
Inclusion Criteria:

          -  age 3 months to 16 years

          -  hospitalization for expiratory wheezing

          -  written informed consent from the parents

        Exclusion Criteria:

          -  Any chronic disease (other than allergy or asthma), e.g. heart disease, immune
             deficiency, or diabetes

          -  varicella and exposure to varicella if not previously have had it

          -  Systemic glucocorticoid 4 weeks prios to the study

          -  Severe disease that needs treatment in the intensive care unit or oxygen saturation
             below 92% despite of additional oxygen and frequent salbutamol inhalations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Role of Referred Pain From the Retro Trochanteric Region in Patients With Knee Pain

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain

          -  Failure to understand the pain with more conventional diagnosis

          -  Symptoms and retrotrochanteric pain with examination

          -  Pain relief with retro trochanteric local anaesthetic injection

        Exclusion Criteria:

          -  Mental illness

          -  Failure to cooperate

          -  Not adequate Norwegian language skills

          -  Other well known disease explaining symptoms
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: MOBILE Study - A Study of Bonviva (Ibandronate) Regimens in Women With Post-Menopausal Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  women 55-80 years of age;

          -  post-menopausal for >= 5 years;

          -  ambulatory.

        Exclusion Criteria:

          -  malignant disease diagnosed within the previous 10 years (except basal cell cancer
             that has been successfully removed);

          -  breast cancer within the previous 20 years;

          -  allergy to bisphosphonates;

          -  previous treatment with an intravenous bisphosphonate at any time;

          -  previous treatment with an oral bisphosphonate within the last 6 months, >1 month of
             treatment within the last year, or >3 months of treatment within the last 2 years.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: The Blood Pressure Effects of Febuxostat in Patients Previously Treated With Allopurinol: A Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  Patients currently treated at the University of Mississippi Medical Center General
             Internal Medicine/Hypertension or Family Medicine Clinics.

          -  Have a diagnosis of gout.

          -  Taking allopurinol at a stable dose for at least 2 months.

        Exclusion Criteria:

          -  Less than 18 years old.

          -  Severe renal impairment defined as CrCl <30 mL/min.

          -  Previous diagnosis of severe hepatic impairment.

          -  Currently taking azathioprine, mercaptopurine, or theophylline.

          -  Pregnant, breastfeeding, or anticipating pregnancy or breastfeeding.

          -  Arm circumference greater than 50 cm.

          -  Change in antihypertensive medication within the previous 2 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Polycan in Combination With Glucosamine for Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of knee osteoarthritis (OA)

          -  OA ranging from grade 1 to grade 3 by Kellgren and Lawrence system

          -  Agree to participate into the study

        Exclusion Criteria:

          -  OA ranging from grade 4 by Kellgren and Lawrence system

          -  Allergic or contradicted with oral NSAIDs (Meloxicam)

          -  Pregnant and breastfeeding women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Tennis Elbow Patients Undergoing Closed Therapy Can Easily Cause Tendon Tear

Eligibility criteria:
Inclusion Criteria:

          -  All patients with tennis elbows in our hospital

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic knee OA

          -  Kellgren- Lawrence grades I - III OA

          -  no or minimal positive effects of previous conservative treatment (rehabilitation,
             hyaluronic acid injections, steroid injections)

          -  VAS pain level minimum 4 in one knee, VAS pain < 2 in the contralateral knee

        Exclusion Criteria:

          -  Use of local corticosteroids up to three months or hyaluronic acid injections up to
             six months prior to the study

          -  Past or present joint infection

          -  Previous knee arthroscopy surgery up to one year prior to examination

          -  Peripheral inflammatory diseases (rheumatoid arthritis, spondyloarthropathies, etc.)

          -  Total arthroplasty and osteotomy

          -  Ankylosis of the joint

          -  Dermatitis or dermatological disease at the intended injection site

          -  Coexistence of degenerative changes in other limb joints (hip, foot)

          -  Cancer

          -  Oral corticosteroid therapy

          -  Use of medicines that affect blood clotting

          -  Pregnancy or breast-feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Iron Overload in African Americans

Eligibility criteria:
Index subjects as well as male and female first and second degree family members, greater
        than 5 years of age, of index subjects with iron overload.

        In some cases, more distant family members will also be studied.

        No patients less than or equal to 5 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment