Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Role of Wrist Based Blood Pressure Monitoring in Clinical Practice

Eligibility criteria:
Inclusion Criteria:

          -  ≥18 years of age

          -  Own an iOS or Android device

        Exclusion Criteria:

          -  Inability to give informed consent

          -  <18 years of age

          -  Inability to understand written English language

          -  Hypertensive urgency or emergency as an admission diagnosis
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Effects of Respiratory Physiotherapy on Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of pleural effusion based on the presence of a consistent radiological
             finding on simple posteroanterior and lateral chest X-rays, and decubitus lateral in
             cases of small PE.

        Exclusion Criteria:

          -  Non diagnosis of pleural effusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Effects of Fear of Falling on Physical Performance and Quality of Life in Children With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with Duchenne Muscular Dystrophy by a pediatric neurologist,

          -  Being volunteer,

          -  Being between 6 and 15 years old,

          -  Being between levels 1-5 according to the Brooke Lower Extremity Functional
             Classification developed to classify lower extremity functions in children with DMD,

          -  Being able to cooperate with the physiotherapist's directives.

        Exclusion Criteria:

          -  Being between levels 6-10 (children who do not have independent ambulatory ability)
             according to the Brooke Lower Extremity Functional Classification,

          -  Not being able to cooperate with the physiotherapist's directives,

          -  End of the volunteering.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Effect of HICT and LIIT on Functional Strength and Weight Efficacy in Overweight and Obese Females

Eligibility criteria:
Inclusion Criteria:

          -  Females with BMI >25 kg/m2.

          -  Females not engaged in routine exercise programs in last 6 months

        Exclusion Criteria:

          -  Females who are using weight loss products.

          -  Females having uncontrolled diabetes, thyroid disease, arthritis, cardiac diseases,
             asthma, hypertension, and recent trauma would not be included in the study.

          -  Females who are pregnant would not be included in the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Study of Depression, Peptides, and Steroids in Cushing's Syndrome

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Patients aged 20 to 60 with spontaneous active Cushing's syndrome

          -  At least 2 weeks since medication with psychoactive effects or influence on cortisol
             metabolism by hepatic hydroxylating enzyme induction

          -  Antihypertensives allowed for severe hypertension

          -  No barbiturates

          -  No phenytoin
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: iBeat Wristwatch Validation Study

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥ 21 years and ≤ 85 years

          2. Able to understand and give informed consent.

          3. Subject is presenting for the following planned procedures:

        3.1 Group A (25 subjects): Subjects presenting for catheter ablation for cardiac
        arrhythmias (e.g. atrial fibrillation, supraventricular tachycardia, or ventricular
        tachycardia) 3.2 Group B (25 subjects): Subjects judged based on the clinical evaluation of
        high, greater than 75%, atrial pacing or ventricular pacing burden or known pacing
        dependence with planned device interrogation for: 1) pacemaker (single or dual chamber), 2)
        implantable cardioverter-defibrillator (single or dual chamber), or 3) cardiac
        resynchronization therapy with or without defibrillator (single or dual chamber plus left
        ventricular pacing).

        3.3 Group C (5 subjects): Subjects for clinically indicated defibrillation threshold
        testing (DFT) (with a transvenous or subcutaneous ICD lead system)

        Exclusion Criteria:

          1. Age < 21 years and > 85 years

          2. Unable to or refuse to give written informed consent

          3. Unwilling or unable to wear the smartwatch device on at least one wrist

          4. Uncorrected severe aortic stenosis or subaortic stenosis (including hypertrophic
             cardiomyopathy) with outflow tract obstruction > 50 mm

          5. New York Heart Association Class IV Heart Failure
No condition on gender to be admitted to the trial.

Subject must be at least 21 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Evaluation of Visual Performance With Contact Lenses

Eligibility criteria:
Inclusion Criteria:

          -  18 to 39 years of age

          -  Best corrected visual acuity of at least 20/30

          -  Spherical equivalent refractive error in each eye of between -0.75 and -6.00 diopters
             sphere after vertexing to the corneal plane

        Exclusion Criteria:

          -  Greater than -1.00 diopter of refractive astigmatism at the corneal plane

          -  Any active anterior segment disease, pathology, or surgery affecting vision,
             refraction, or the ability to wear a soft contact lens

          -  History of ocular trauma or surgery causing abnormal or distorted vision

          -  Current Rigid Gas Permeable (RGP) contact lens wearers

          -  Unwilling to have eyes photographed or video recorded

          -  Pregnant and/or lactating females, by self-report
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Verification of the Efficacy/Safety of the Dual Drug Delivery for Hearing Loss

Eligibility criteria:
Inclusion Criteria:

          -  Sudden hearing loss, ototoxic hearing loss, noise-induced hearing loss, meniere's
             disease patients with 25dB HL in pure tone audiometry

          -  Patients whose hearing has not been restored after standard treatment

          -  Patients do not participate in clinical trials within 6 months

        Exclusion Criteria:

          -  Patients with retrocochlear lesion

          -  Patients with history of hypersensitivity to the substance of this drug
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Biomarkers in Primary Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Patients: cross sectionally patients will be included for clinical suspicion of
             primary SS or with the diagnosis already established in Rheumatology unit.

        The following inclusion criteria will be applied to the study:

          -  Age > 18 years

          -  Informed consent of the patient.

        Exclusion Criteria:

          -  Impossibility of obtaining consent (cognitive impairment, other causes).

          -  Associated systemic autoimmune or rheumatological diseases.

          -  Chronic viral infections (HCV, HBV, HIV).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient's own account: I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Clinical trial: Study of Tongue Strengthening for Swallowing Problems

Eligibility criteria:
Inclusion Criteria:

          -  referral by a physician for swallowing evaluation because of suspected dysphagia

          -  complaint of difficulty swallowing

          -  aspiration or penetration of the laryngeal vestibule with liquids or semisolids OR
             post-swallow residue visible in the oral cavity, valleculae, or pharynx that is
             instrumentally documented by a participating SLP during a standard clinical
             videofluoroscopic swallowing study

          -  between the ages of 21 and 95

          -  ability to perform the exercise protocol independently or with the assistance of a
             caregiver

          -  physician approval of medical stability to participate

          -  decision-making capacity to provide informed consent (confirmed through discussion
             between the participating SLP and the subject's primary physician)

        Exclusion Criteria:

          -  degenerative neuromuscular disease

          -  poorly controlled psychosis

          -  patient unable to complete the exercise program

          -  allergy to barium (used in videofluoroscopic swallowing assessment)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Inflammatory Mediators in Erythema Migrans

Eligibility criteria:
Inclusion Criteria:

          -  erythema migrans in patients > 18 years

        Exclusion Criteria:

          -  pregnancy or immunocompromising conditions

          -  taking antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment