Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Basic Study of Combination Therapy Based on APCC-induced FVllI Activation in Hemophilia A Patients With Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hemophilia A with inhibitors (Inhibitor titer; >0.5 Bethesda U/ml)

          -  Patients with agreement consents with the patients signatures

        Exclusion Criteria:

          -  Patients that do not fill the conditions described above
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Electronic Patient Reported Outcome (ePRO) Mobile Application Pragmatic Trial

Eligibility criteria:
Inclusion Criteria:

          1. a FHT patient at one of the FHT sites selected and is 60 years or older;

          2. physical capability to use a tablet and/or a caregiver who can use the tablet on their
             behalf;

          3. ability to read and write in English and/or the availability of a caregiver who can do
             so on their behalf;

          4. has complex care needs defined as two or more chronic conditions and 10 or more visits
             to their primary health care provider within the last 12 months; and

          5. be thinking about or ready to make changes to support their self-management.

        In addition patients can self-identify and join the study, as well as providers can
        identify other patients they feel fit our eligibility criteria that may not have been
        pulled from the EMR system. This allows eligible patients to enroll into the study that may
        have been missed when identifying patients through the EMR system.

        Exclusion Criteria:

        1. Absence of Inclusion Criteria
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Oral Contraceptives and Body Mass Index

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-35

          -  BMI > 30kg/m2

          -  Proof of a normal breast and pelvic exam within last 9 months

          -  Self reported normal menstrual periods (24-35 days)

          -  Good general health

          -  In the investigator's opinion, are subject's veins suitable the repeat blood draws
             dictated by study protocol

          -  Single progesterone level during screening visit ≥ 3ng/mL

          -  Hematocrit ≥ 36%

        Exclusion Criteria:

          -  Contradictions to COCs (history of deep vein thrombosis,myocardial infection,
             uncontrolled hypertension, pulmonary embolus, diabetes with vascular changes, stroke,
             migraines with neurologic changes, breast cancer, impaired liver function,
             uncontrolled thyroid disease, hypersensitivity or allergy to birth control)

          -  Smoker (must smoke 0 cigarettes)

          -  Actively seeking/involved in a weight loss program

          -  Currently pregnant/seeking pregnancy in the next 6 months

          -  Currently breast-feeding

          -  Past or current diagnosis of polycystic ovarian disease

          -  Recent use of birth control (Depot medroxyprogesterone: 6 months, Progestin implants:
             6 months, Oral contraceptives, patch or ring: 2 months, Hormone impregnated IUD: 6
             months)

          -  Currently taking medication that interferes with COC's (Rifampin, Carbamazepine, St.
             John's Wort)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation

Eligibility criteria:
Inclusion Criteria:

          -  Documented stable refraction for at least 1 year(within 0.5D)

          -  Best spectacle-corrected visual acuity (BCVA) of 20/40 or better

          -  Clear central cornea

          -  -0.5D to -18.0D of myopic refractive error

          -  Normal anterior chamber depth at least 2.8 mm to endothelium

          -  Endothelial cell density (ECD) more than 2000 cell/mm2

          -  Pupil diameter smaller than 7.0 mm under mesopic condition

          -  Discontinued 3 weeks for hard contact lens and 1 week for soft contact lens wear

        Exclusion Criteria:

          -  Preexisting ocular diseases or conditions other than myopia, evidence of progressive
             or acute ocular disease

          -  Evidence of connective tissue disease or other systemic diseases that may confound the
             results of the study;

          -  Narrow angle of anterior chamber

          -  Pregnant, lactating, or planning to become pregnant during the course of the trial
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Vitamins and Minerals for Children With Downs Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Under 7 months of age

          -  Trisomy 21

          -  Live in recruitment Area-i.e. London inside M25, in West Midlands or SW England.

          -  One parent speaks English

        Exclusion Criteria:

          -  No life threatening cardiac disease
No condition on gender to be admitted to the trial.


Subject must be at most 7 Months

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Oxycodone-naloxone in Relieving Opioid-related Constipation

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects at lest 18 years or older with pain.

          -  Subjects must report constipation caused or aggravated by opioids.

        Exclusion Criteria:

          -  Females who are pregnant or lactating.

          -  Subjects with evidence of significant structural abnormalities of the gastrointestinal
             (GI) tract (e.g. bowel obstruction, strictures).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Biomechanical Evaluation of Wrist Ligament Injuries: Diagnostic Tool to Detect Wrist Instability

Eligibility criteria:
Inclusion Criteria:

          -  patients who have suffered ligamentous injuries to their wrists and have been referred
             to the principal investigator

          -  subject selected to undergo surgery

          -  The ethnicity and racial makeup of the group is similar to the demographics of the
             surrounding referral base

          -  There will be no exclusion of any gender, racial or ethnic group

        Exclusion Criteria:

          -  Pregnant women will not be included because of increased anesthetic risks at surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Sleep Disorders and Their Cardiovascular Correlates in Atahualpa.

Eligibility criteria:
Inclusion Criteria: all Atahualpa residents aged 40 years or more -

        Exclusion Criteria: persons not signing the informed consent form

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)

Eligibility criteria:
Inclusion Criteria:

          -  Previously diagnosed (e.g. more than 6 months ago) primary or secondary adrenal
             insufficiency with a stable daily glucocorticoid substitution dose for at least 3
             months prior to study entry

          -  Signed informed consent to participate in the study

        Exclusion Criteria:

          -  acute primary or secondary adrenal insufficiency

          -  clinical or laboratory signs of significant cerebral, cardiovascular, respiratory,
             hepatobiliary, pancreatic disease

          -  clinically significant renal dysfunction

          -  any medication with agents which could interfere with glucocorticoid kinetics
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions.

Eligibility criteria:
Inclusion Criteria:

          -  Speak English

          -  Have a symptomatic form of the disease.

          -  Are at least 18 years of age.

        Exclusion Criteria:

          -  Known or suspected sensitivity to non-steroidal anti-inflammatory medication

          -  History of asthma

          -  History of gastrointestinal ulceration

          -  History of bleeding disorders

          -  Use of anti-inflammatory agents in the last 24 hours

          -  Use of systemic steroid medication in the last 14 days.

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Pain Blocking During Drug Administration or Blood Collection With Needles

Eligibility criteria:
Inclusion Criteria:

          -  Receiving an injection with a needle

          -  Able to score the pain on a scale of 0-10 using the universal pain assessment tool,
             preferably 7 years of age or older

        Exclusion Criteria:

          -  Current pregnancy

          -  Inability to understand and carry out instruction
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment