Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Covalent Tolerance Induction to Factor VIII-Prediction of Inhibitors in Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Severe Hemophilia A with an inhibitor level of 0.6 B.U. or higher

        Exclusion Criteria:

          -  Severe Hemophilia A with a negative inhibitor
Male
No healthy subjects accepted to join the trial.

Subject must be at most 99 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin

Eligibility criteria:
Key Inclusion Criteria:

          -  Medically healthy, with no clinically significant medical history, physical
             examination findings, vital signs, or ECG findings

        Key Exclusion Criteria:

          -  Estimated creatinine clearance <90 mL/min

          -  Use of tobacco- or nicotine-containing products

          -  History in the past 90 days of prior trauma to the outer or internal structures of the
             ear or tinnitus

          -  History or family history of vestibular disorder, chronic vertigo (sensation of
             spinning), chronic dizziness

          -  History of hearing loss or a family history of hearing loss, or a prior diagnosis of
             sensorineural hearing loss or Ménière's disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  patients with interstitial lung disorders including IPF

        Exclusion Criteria:

          -  patients younger than 18 years or older than 85,

          -  pregnant women,

          -  patients that present with medical conditions contra -indicated for performing
             bronchoscopy including sedation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female, aged 18 to 60 years, inclusive.

          -  Body mass index 19.0 to 35.0 kg/m2

          -  Intact normal skin without potentially obscuring tattoos, pigmentation, or lesions on
             the upper back in the area intended for infusion

          -  Free from any clinically significant abnormality on the basis of medical/medication
             history or physical examination

          -  Vital signs and clinical laboratory parameters within normal range or, if outside
             normal range, deemed not clinically significant

          -  Negative urine drug and alcohol screens.

        Exclusion Criteria:

          -  Upper back pathology that could interfere with study outcome.

          -  History of congestive heart failure, known coronary heart disease, active or recent
             pulmonary disease, or renal insufficiency.

          -  Rales on lung auscultation.

          -  Known allergy to hyaluronidase or any other ingredient in the formulation of hylenex
             recombinant

          -  Treatment with furosemide, benzodiazepines, or phenytoin.

          -  Pregnancy or breastfeeding.

          -  Exposure to any experimental drug within 30 days prior to study admission, or previous
             participation in this study.

          -  Any other reason which, in the investigator's opinion, would prevent the safe
             participation in the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: A Study of Disposable Transnasal Esophagoscope

Eligibility criteria:
Inclusion Criteria:

          1. aged 20 years or older

          2. endoscopy indicated for reflux symptoms (heartburn, epigastric soreness and/or
             regurgitation), dyspepsia (epigastric discomfort, bloating, early satiety), or
             non-cardiogenic chest pain, or known or suspected to have esophageal varices,
             infectious esophagitis, or other esophageal disease based on their medical history

          3. a written informed consent form

        Exclusion Criteria:

          1. history or symptoms of severe rhinitis and sinusitis

          2. symptoms of acute respiratory inflammation at the time of examination

          3. abnormal anatomy of the nasal cavity or nasopharynx due to nasal tumors or previous
             nasopharyngeal surgery

          4. taking anticoagulants such as coumadin

          5. patients for whom a EGD could not be performed
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Basivertebral Nerve Block During Vertebral Augmentation: An Alternative Approach to Intraprocedural Pain Management

Eligibility criteria:
Inclusion Criteria:

          -  Age >50 years old

          -  Patient must have a diagnosis of osteoporosis on dual energy x-ray absorptiometry
             (DEXA),

          -  Patient must have an acute or subacute single level vertebral compression fracture
             between T10 - L3 as confirmed via magnetic resonance imaging (MRI) or nuclear medicine
             bone scan,

          -  Patient must have an initial pain score of greater than or equal to five using a
             standard 0-10 Visual Analog Scale subjective pain score upon initial consultation.

        Exclusion Criteria:

          -  Pathologic compression fracture, such as due to metastatic disease

          -  Age >90 years old or <50 years old

          -  Pregnancy

          -  Diagnosed Anxiety Disorder

          -  Diagnosed Depression Disorder

          -  Diagnosed Psychotic Disorder

          -  Diagnosed Mental Disease Disorder

          -  Diagnosed Parkinson's disease/other movement disorders/or cerebellar dysfunction

          -  Eastern Cooperative Oncology Group (ECOG) score at baseline prior to compression
             fracture >1

          -  Back Pain scores at time of initial consult <5, using a standard Visual Analog Scale

          -  Illicit drug dependence or abuse

          -  Alcohol dependence or abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Cabergoline on Endometrial Vascularity During IntraCytoplasmic Sperm Injection

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥18 - ≤40 years

          2. Normal serum prolactin level.

          3. Tubal factor of infertility.

          4. Unexplained infertility.

          5. BMI ≥ 30 kg/m2.

          6. Estradiol (E2)>3,500 pg/ml on day of ovulation trigger.

          7. Patients who underwent coasting for OHSS prevention.

          8. More than 20 follicles ≥11 mm on the day of final oocyte maturation.

        Exclusion criteria:

          1. Contraindication of pregnancy e.g.: Somatic and mental diseases, which are
             contraindications for carrying of a pregnancy and childbirth, inborn malformations or
             acquired deformations of uterus cavity which make embryo implantation or carrying of a
             pregnancy impossible ,ovarian tumors.

          2. Severe Male factor infertility.

          3. Hyperprolactinemic patients.

          4. Frozen embryo transfer cycles

          5. Uterine Anomalies.

          6. Uterine synechia.

          7. History of Genital Tuberculosis.

          8. Repeated implantation failure in ICSI.

          9. On medication that is known to alter prolactin levels e.g antipsychotics, Atypical
             agents and risperidone

         10. Thyroid dysfunction.

         11. Medical disorders affecting serum prolactin eg acromegaly ,chronic renal failure and
             hypothyroidism
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Characteristics and Outcomes of Hospitalized Patients With COVID-19 in Spain

Eligibility criteria:
Inclusion Criteria:

          -  Laboratory-confirmed COVID-19 infection by real-time polymerase chain reaction
             (RT-PCR) assay

          -  Hospital admission

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Detailed Pain Pattern After Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  men

          -  18-69 years

          -  uni- or bilateral hernia

          -  ASA I-II

          -  Danish speaking

        Exclusion Criteria:

          -  bad compliance

          -  acute operation

          -  daily intake of opioids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 69 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Exercise Study Including Patients With Hypertrophic Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          1. Ages 18 - 80 years old.

          2. Diagnosis of hypertrophic cardiomyopathy, defined by the presence of unexplained
             left-ventricular hypertrophy (wall thickening) > 13 mm in any wall segment.

          3. Exercise £ 30 minutes, 1 day per week for the previous 3 months.

          4. Agreement to be a participant in the study protocol and willing/able to return for
             follow-up.

        Exclusion Criteria:

          1. History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
             non-sustained ventricular tachycardia).

          2. Medically refractory LV outflow tract obstruction being evaluated for septal reduction
             therapy.

          3. Less than 3 months post septal reduction therapy (surgery or catheter based
             intervention).

          4. Hypotensive response to exercise (> 20 mmHg drop in systolic blood pressure from peak
             blood pressure to post exercise blood pressure).

          5. Pregnancy.

          6. ICD placement in last 3 months or scheduled.

          7. Life expectancy less than 12 months.

          8. Inability to exercise due to orthopedic or other non-cardiovascular limitations.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction