Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: the Investigation Into Beneficial Effects of High-dose Interferon Beta 1-a, Compared to Low-dose Interferon Beta 1-a in Moderate to Severe Covid-19

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18

          -  COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed)

          -  at least one of the following: radiation contactless body temperature ≥37.5, cough,
             shortness of breath, nasal congestion/ discharge, myalgia/arthralgia,
             diarrhea/vomiting, headache or fatigue on admission.

          -  Time of onset of the symptoms should be acute (Days ≤ 14)

          -  NEWS2 ≥ 1 on admission (National Early Warning Score 2)

        Exclusion Criteria:

          -  Refusal to participate expressed by patient or legally authorized representative if
             they are present

          -  Patients using drugs with potential interaction with Lopinavir/Ritonavir or
             Interferon-β 1a

          -  Pregnant or lactating women.

          -  History of alcohol or drug addiction in the past 5 years.

          -  Blood ALT/AST levels > 5 times the upper limit of normal on laboratory results.

          -  The patients who were intubated less than one hours after admission to the hospital
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Journey of Patients With Vasculitis From First Symptom to Diagnosis

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of a systemic vasculitis: The V-PPRN includes patients with self-reported
             Behçet's disease, central nervous system vasculitis, cryoglobulinemic vasculitis,
             eosinophilic granulomatosis with polyangiitis (Churg-Strauss Syndrome, CSS), giant
             cell (temporal) arteritis (GCA), granulomatosis with polyangiitis (Wegener's, GPA),
             IgA vasculitis (Henoch-Schönlein Purpura), microscopic polyangiitis (MPA),
             polyarteritis nodosa (PAN), Takayasu's arteritis (TAK), and urticarial vasculitis.

          2. Language requirements: questionnaire will be in English only

        Exclusion Criteria:

          1. Inability to provide informed consent and complete survey in English

          2. Patients with a diagnosis of "other" type of vasculitis

          3. Patients with a "missing" diagnosis -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Ex Vivo Laboratory Assays Application for Therapy Tailoring in Patients With Severe Bleeding Disorders

Eligibility criteria:
Inclusion Criteria:

          -  Informed consent

          -  Validated coagulation disorder

        Exclusion Criteria:

          -  Not consenting to participate

          -  Multiple coagulopathies and comorbidities
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Developing a Biomarker for Monitoring Clinical Outcomes in Children With Spinal Lipoma.

Eligibility criteria:
Inclusion Criteria:

          -  patient with proven spinal lipoma

        Exclusion Criteria:

          -  complex spinal lipomas related to other developmental abnormalities
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception.

Eligibility criteria:
Inclusion Criteria:

          -  Regular menstrual cycles

          -  sexually active and at risk of pregnancy

          -  nonpregnant

          -  normal Pap smear

        Exclusion Criteria:

          -  Presently have or at risk of venous thrombosis or arterial thrombosis

          -  migraines with focal aura

          -  severe hypertension

          -  diabetes mellitus

          -  hereditary dyslipoproteinemia

          -  carcinoma of breast, endometrium or other estrogen-dependent neoplasia

          -  substance abuse

          -  skin conditions

          -  concurrent use of hormone-containing medication

          -  smoking women over 35 years of age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed patient COVID19 positive with clinical signs of acute lower respiratory
             infection with signs of pneumonia or bronchitis: fever and / or cough and / or
             difficulty breathing in the absence of acute respiratory failure (PaO2> 60 mmHg) with
             Plus or less :

               -  Chills

               -  Asthenia, fatigability

               -  Headache

               -  Arthromas myalgia

               -  Dry throat

               -  Rhinorrhea

               -  An anosmia

               -  chest pain

               -  Diarrhea

               -  Nausea and vomiting

                    -  Absence of rhythm disturbance (Qt interval <500ms)

                    -  Patients hospitalized in the medical service

                    -  18 years old <Age <80 years old

                    -  Having given written consent for their participation in the study

        Exclusion Criteria:

          -  Allergy to macrolides, local anesthetics such as lidocaine or amide type and
             betalactamines

          -  Take hydroxychloquine in the previous month

          -  Severe / severe liver failure

          -  Kidney failure (GFR <30 ml / min / 1.73 m2)

          -  Ongoing treatments with colchicine, ergot, rye, pimozide, mizolastine, simvastatin,
             lomitapide, alfuzosin, dapoxetine, avanafil, ivabradine, eplerenone, dronedarone,
             quetiapine, ticagrelor, cisapride, astemizole, terfenadine, ranolazine, domperidone.

          -  Complete branch block

          -  Hypovolemia

          -  Retinopathy including vitreous involvement

          -  Psoriasis

          -  Pregnant or breastfeeding woman

          -  hypersensitivity to chloroquine or hydroxychloroquine or to any of the other
             ingredients of this medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Idiopathic Pulmonary Fibrosis Job Exposures Study

Eligibility criteria:
For cases

        Inclusion Criteria:

          -  New diagnosis of IPF between February 2017 and October 2019

        Exclusion Criteria:

          -  Unable to give informed consent

          -  Ever worked outside of the UK

        For controls

        Inclusion Criteria:

          -  New outpatient department attendee between February 2017 and October 2019

        Exclusion Criteria:

          -  Unable to give informed consent

          -  Ever worked outside of the UK (does not include work outside the UK by members of the
             armed forces or merchant navy)

          -  Diagnosis of IPF
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Study Evaluating the Impact of Mesh Pore Size on Chronic Pain After Lichtenstein Hernioplasty

Eligibility criteria:
Inclusion Criteria:

          -  age ≥18 years

          -  unilateral primary reducible inguinal hernia

          -  elective operation

          -  consent to participate in the study.

        Exclusion Criteria:

          -  age <18 years

          -  irreducible

          -  strangulated

          -  recurrent hernia

          -  inability to understand the questionnaire

          -  unwillingness to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Efficacy of Severe Whitening and Delayed Fading in Acetic Acid-enhanced Endoscopy for Diagnosing Gastric Intestinal Metaplasia

Eligibility criteria:
Inclusion Criteria:

          -  long-lasting upper gastrointestinal symptoms (>15 years)

          -  atrophic gastritis or GIM identified at surveillance endoscopy

        Exclusion Criteria:

          -  presence of advanced adenocarcinoma in the stomach

          -  presence of acute gastrointestinal bleeding

          -  presence of coagulopathy, uncontrolled impaired renal or liver disease

          -  presence of pregnancy or lactation

          -  presence of allergy to acetic acid

          -  age younger than 18 years or older than 80 years

          -  inability to provide written informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Essential Tremor diagnosed by criteria listed in the Consensus statement of the
             Movement Disorders Society on Tremor

          -  Age 18 - 85 years of age

          -  Motor skills allowing for capability to complete evaluations

          -  Medically cleared for undergoing anesthesia and DBS surgery

        Exclusion Criteria:

          -  Dementia per DSM-V criteria

          -  Medical or other condition precluding MRI

          -  History of supraspinal CNS disease other than Essential Tremor

          -  Alcohol use of more than 4 drinks per day

          -  Pregnancy

          -  History of suicide attempt

          -  Currently uncontrolled clinically significant depression (BDI>20)

          -  History of schizophrenia, delusions, or currently uncontrolled visual hallucinations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Care Management for Patients With Alzheimer Disease and Their Family Caregivers

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimers Disease

        Exclusion Criteria:

          -  Inability to understand English

          -  No telephone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Entailment