Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Osteoporosis Screening Trial

Eligibility criteria:
Inclusion Criteria:

          -  Females

          -  Postmenopausal women

          -  Outpatients screened for osteoporosis

          -  Women > 45 years

          -  Women < 45 years under menopause

          -  Women obtained their consent to be measured

        Exclusion Criteria:

          -  Premenopausal females

          -  Women without any symptom of menopause

          -  Women not obtained their consent to be measured
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: The Natural History of Atopic Disease in Thai Children and Association With Atopic March

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of AD by physician at birth-15 years old

          -  Diagnosed by physician by Hanifin and Rajka criteria: itching, dry skin, chronic
             dermatitis : at face, extensor area (infant), flexor area (children and adult), with
             or with out history of atopy in family

          -  Follow at allergy clinic once a year or can ask current symptom via telephone
             interview.

          -  Evaluate severity of the disease by SCORAD (Scoring Atopic Dermatitis )

        Exclusion Criteria:

          -  Onset of atopic dermatitis more than 15 years old.

          -  Other disease: skin, cardiovascular, liver disease, endocrine, neurology, ect

          -  Not complete data collection in case record form in out patient record.

          -  Cannot be reach current symptom of patient.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Effectiveness of Steroid Injection in Treating Patients With Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  age 18 to 65 years

          -  confirmed lateral epicondylitis

          -  had not received any treatment prior to enrolment

        Exclusion Criteria:

          -  symptoms lasting less than 6 weeks

          -  history of acute trauma, fracture, and/or surgery within 12 months

          -  patients who had received corticosteroid injection, physiotherapy, splint or casting
             during the past 6 months

          -  bilateral involvement and history of cervical disk herniation, radiculopathy or
             abnormal electrophysiologic study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Horses and Education as Arthritis Therapy

Eligibility criteria:
Inclusion Criteria:

        - Ages 45 and older

        Joint pain inclusion will be considered with a mild [Mild pain (0-44)] to moderate pain
        level [Moderate pain (45-74 mm)] (Hawker, Mian, Kendzerska, & French, 2011) not completely
        relieved by medications.

        Measured decreased range of motion by 20% (back, shoulder, knee and hip) and hip abduction
        wide enough to straddle a horse without discomfort.

        Written physician's or advanced practice registered nurse's (APRN) clearance to ride a
        horse.

        Ability to read and understand English as evidenced by the capacity to follow verbal and
        written directions at the screening interview.

        Exclusion Criteria:

        Self-reported: fear of horses.

        Self reported allergies to horses.

        Self reported osteoporosis.

        Inability to abduct hips wide enough to straddle a horse comfortably.

        Lack of transportation to the Therapeutic Riding Center.

        Horse riding for the previous six months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Safety and Immunogenicity of Inactivated Vaccine Against COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

        -Healthy healthcare workers

        Exclusion Criteria:

          -  Healthy healthcare workers' refusal.

          -  Pregnancy and lactation.

          -  Confirmed acute cases of SARS-CoV-2 Infection

          -  Having a history of SARS-CoV-2 infection in the past 3 months.

          -  Fever (body temperature > 37.0 ℃), dry cough, fatigue, nasal obstruction, runny nose,
             pharyngeal pain, myalgia, diarrhea, shortness of breath and dyspnea occurred within 14
             days before vaccination.

          -  History of allergy to any vaccines

          -  Previous vaccination within the last 30 days
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  healthy males, who are not taking Tamsulosin regularly who are undergoing elective
             inguinal hernia repair (laparoscopic, open, and robotic assisted)

        Exclusion Criteria:

          -  Patients who are already taking tamsulosin, terazosin (alpha blocker treatement for
             BPH) , finasteride, dutasteride ( both 5 alpha reductase inhibitors), sulfa allergy,
             and lactose allergy
Male
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Pain Phenotypes in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Age 50-85

          -  Diagnosed with Knee Osteoarthritis by a physician or by ACR clinical criteria

        Exclusion Criteria:

          -  sensory dysfunction due to injury (i.e. known nerve damage)

          -  neurological diagnosis affecting sensory or motor function (e.g. stroke, Parkinson's
             Disease, multiple sclerosisetc.)

        Healthy Volunteers eligibility criteria:

          -  Age 50-85

          -  Do not possess knee osteoarthritis diagnosis

          -  do not have knee pain

          -  do not have a history major knee trauma or lower extremity trauma or surgery

          -  do not have any other pain condition
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hemophilia A who have been treated with factor VIII on demand or on
             prophylaxis and who have developed inhibitors to factor VIII

          -  ≤ 2 years from the time of first inhibitor detection.

          -  High-responding inhibitors (historical peak > 5 BU/mL)and known anamnestic response in
             case of negative inhibitor titre.

          -  Candidates to start daily ITI with FVIII doses ranging from 50 IU/Kg/day to 200
             IU/Kg/day

          -  Maximal two bleedings in the same joint within the last 6 months before entering the
             study or maximal six joint bleeds in the same joint within 2 years

          -  Adequate venous access for daily infusion and capable (caregiver) of reconstituting
             and injecting the study drug

          -  Informed consent by parents or legal guardians.

        Exclusion Criteria:

          -  ITI already started

          -  Known or suspected hypersensitivity to the active substance or to any of the
             excipients of the study drug

          -  Administration of any investigational product within 30 days prior to randomisation

          -  Other coagulation disorders than congenital hemophilia A.

          -  Family history of thrombosis at an early age (< 40 years), known thrombophilia, any
             previous thrombosis including catheter-related deep vein thrombosis, previous neonatal
             thrombosis.

          -  Known pseudo tumours

          -  Known severe liver disease

          -  Platelet count < 50,000 platelets/µL at screening

          -  Surgery within one month or planned major and/or orthopaedic surgery.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 8 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic with COVID illness (either RT-PCR test confirmed or highly suspect
             clinical symptoms)

          -  Call into office within the first 7 days of illness

          -  Have any of the following high risk conditions:

               -  Age >60

               -  HTN, CAD, or chronic heart disease

               -  Diabetes

               -  Chronic kidney disease

               -  Chronic lung disease

               -  Active or recent chemotherapy for malignancy

               -  Organ transplant

               -  Taking Immune-suppressing medications

               -  HIV with CD4 <200 cells/mm3

          -  Experiencing at least one of the following high risk symptoms:

               -  Severe cough

               -  Fever 100.0F or greater

               -  Diarrhea

               -  Shortness of Breath

               -  Hypoxia

        Exclusion Criteria:

        • HCW not meeting high-risk criteria or those with a contraindication to HCQ will not be
        offered HCQ
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: SuPRA: Using Wearable Activity Trackers With a New Application to Improve Physical Activity in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Have a physician confirmed diagnosis of knee osteoarthritis OR are both 1) over 50,
             and 2) have experienced 4 weeks of pain, aching, or discomfort in or around the knee
             during the last year (equal to or more than 28 separate or consecutive days).

          -  Have no previous diagnosis of inflammatory arthritis (e.g., rheumatoid arthritis,
             psoriatic arthritis, ankylosing spondylitis), connective tissue diseases, or gout.

          -  Have no history of using disease-modifying anti-rheumatic drugs, such as
             hydroxychloroquine, sulfasalazine, methotrexate, biologic agents (e.g., Humira,
             Enbrel), or gout medications.

          -  Have no prior knee arthroplasty, and not on a waiting list for total knee replacement
             surgery.

          -  Have no history of acute injury to the knee in the past 6 months.

          -  Have not had surgery in the back, hip, knee, or ankle joints in the past 12 months.

          -  Have an email address and use online/mobile applications.

          -  Are able to attend one 1.5-hour education session.

        Exclusion Criteria:

          -  Have received a hyaluronate injection in a knee in the last 6 months.

          -  Have received a steroid injection in a knee in the last 6 months.

          -  Are at risk when exercising, as identified by the Physical Activity Readiness
             Questionnaire.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment