Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Malignant pleural effusion diagnosed by pleural fluid cytology and / or pleural
             biopsy;

          -  Recurrent pleural effusion (new accumulation of fluid after puncture) and symptoms
             (dyspnea and / or chest pain);

          -  Complete lung expansion (> 90%) after puncture emptying confirmed by chest
             radiography;

          -  Karnofsky index (KPS - Karnofsky Performance Status) > 30;

          -  Agreed to participate in the study and sign an informed consent.

        Exclusion Criteria:

          -  Thrombocytopenia or coagulation disorders (prothrombin activity <50% and platelet
             count <80,000 mm3);

          -  Endobronchial obstruction by the neoplasm;

          -  Major pulmonary fibrosis or lymphangitis carcinomatosis ipsilateral to the effusion;

          -  Volume drained <800 mL;

          -  No contact between the pleural surfaces after draining;

          -  Pleural or active systemic infection;

          -  Massive neoplastic infiltration of the skin;

          -  Inability to understand the quality of life questionnaire;

          -  Age less than 18 years;

          -  Previous pleural procedures (except punctures and needle biopsies).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients

Eligibility criteria:
Inclusion Criteria:

          -  Amyotrophic Lateral Sclerosis (ALS) volunteers must be diagnosed within the 3 years
             prior to participation as having possible, probable, or definite ALS, either sporadic
             or familial according to modified El Escorial criteria

          -  Age 18-80, able to provide informed consent, and comply with study procedures

          -  Participants must not have started riluzole for at least 30 days, or be on a stable
             dose of riluzole for at least 30 days, prior to screening (riluzole-naïve participants
             are permitted in the study)

          -  Slow VC test equal to or greater than 50% of the predicted value

        Exclusion Criteria:

          -  The presence of unstable psychiatric disease, cognitive impairment, or dementia that
             would impair ability of the participant to provide informed consent

          -  Exposure to any experimental agent within 30 days of entry or at any time during the
             trial or enrollment in another research study within 30 days of or during this trial

          -  Women who are breastfeeding, who are pregnant or are planning to become pregnant

          -  Renal insufficiency as defined by a serum creatinine > 1.5 times the upper limit of
             normal

          -  Hepatic insufficiency or abnormal liver function (AST and/or ALT greater than 3 times
             the upper limit of the normal range)

          -  Slow VC test less than 50% of the predicted value

          -  ECG finding of QTc prolongation > 450 ms

          -  Patients who had already undergone tracheostomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Low Von Willebrand in Ireland Cohort Study

Eligibility criteria:
Inclusion Criteria:

          -  Two lowest VWF levels (VWF Antigen and/or VWF Ristocetin cofactor activity and/or VWF
             Collagen Binding) >30 IU/dL <50 IU/dL.

        Exclusion Criteria:

          -  Pregnant patients

          -  Hospitalised patients/acutely unwell patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Bisoprolol in DMD Early Cardiomyopathy

Eligibility criteria:
Inclusion Criteria:

          -  Older than(including) 7 years old

          -  A definite diagnosis of DMD with muscle pathology confirming the expression of
             dystrophin lower than 5% and/or confirmed mutations in the DMD gene using a clinical
             accepted technique that completely defines the mutation.

          -  Using ACEI or ARB for more than 1 month

          -  Confirmed myocardial damage in one or more left ventricular segments evident by late
             gadolinium enhancement and preserved left ventricular systolic function(>45%) by cine
             cardiac MR in 45 days

          -  Normal renal function

          -  Holter and blood pressure shows no contraindication of using bisoprolol

        Exclusion Criteria:

          -  Having metal implanted in body

          -  Having claustrophobia

          -  Allergic to gadolinium

          -  Complicated with other cardiovascular diseases

          -  Medical history or Holter show bradyarrhythmia like II/III degree atrioventricular
             block, sick sinus syndrome etc.

          -  Systolic blood pressure lower than 90mmHg or rest heart rate lower than 75bpm

          -  Having COPD or asthma history

          -  Having other complications: tumor, endocrine diseases

          -  Having beta blockers therapy

          -  Planned operation in the future 12 months

          -  Allergic to bisoprolol
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis from GP confirming Lyme disease and/or

          -  Blood test confirming Lyme disease and/or

          -  Symptoms that correlate to Lyme disease without diagnosis from GP. This is called
             "self diagnosis" and because 80% of the trial is focused on treating symptoms and not
             the spirochetes, bacteria or small cysts of Lyme disease, the results are expected to
             be largely the same

        Exclusion Criteria:

          -  Persons currently undergoing antibiotic treatment for Lyme or other conditions

          -  Persons who were prescribed antibiotics but did not or could not take them
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 14 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Strategies for Management of Knee Osteoarthritis : Innovation and Medico-economic Study

Eligibility criteria:
Inclusion Criteria:

          -  moderate or severe knee osteoarthritis

        Exclusion Criteria:

          -  another disease than knee osteoarthritis
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: LD-FUD for Highly Aggressive Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Pathologically confirmed gastric adenocarcinoma;

          -  Bone marrow metastasis confirmed by biopsy;

          -  PLT < 50*10E9/L;

          -  Sufficient liver and renal functions;

        Exclusion Criteria:

          -  treated by cytotoxic or target or I-O drugs;

          -  insufficient cardiac or pulmonary function;

          -  active infection;

          -  no contraceptive measures;
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Infants With Down Syndrome on a Different Surface

Eligibility criteria:
Inclusion Criteria:

          -  Infants aged between 3 and 5 months in both groups

          -  Infants without any neurological, genetic or metabolic disorder diagnosis in the
             control group

        Exclusion Criteria:

          -  Infants whose parents did not want to participate study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Weeks old.
Subject must be at most 19 Weeks

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: A Study of Factor Inhibitors in Adult Patients With Hemophilia and Von Willebrand's Disease in Upper Egypt

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed congenital hemophilia A, Christmas disease, and VWD

        Exclusion Criteria

          -  Patients diagnosed with acquired hemophilia

          -  Patients below 18 years

          -  Patients with other bleeding tendencies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Study About Lymphocytes Change During Menstrual Cycle in Women of Child-bearing Age

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 20-49;

          -  Having a regular menstrual cycle of which the menstrual period is between day 3-7, and
             the period between day 25-35;

          -  Excluding internal and surgical disease (after having variety of physical examination
             such as electrocardiogram/hepatic and renal function/blood routine and urine routine).

        Exclusion Criteria:

          -  Having experienced severe allergies, trauma history and/or operation history within 3
             months;

          -  With a history of mental illness and/or family history of mental illness;

          -  Limb disabled;

          -  Taking medicine within one month;

          -  Suffering major events or having mood swings.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women who are referred to the department

          -  benign condition requiring hysterectomy

          -  Dysmenorrohea/cyclic pelvic pain

          -  Informed consent

        Exclusion Criteria:

          -  Women who are unable to communicate in Norwegian language.

          -  Women with a previous history of cervical dysplasia, with cellular changes suggestive
             of dysplasia in preoperative cervical smear.

          -  Women with atypical hyperplasia or malignancy in preoperative endometrial biopsy.

          -  Women with a substantially enlarged uterus requiring abdominal hysterectomy or not
             suitable for TLH (> 12 week amenorrhea).

          -  Women with a concomitant condition requiring uni- or bilateral oophorectomy.

          -  Postmenopausal women.

          -  Women with no dysmenorrohea/cyclic pelvic pain (<1 on a 10-point visual analogue
             scale).

          -  Women with deep infiltrating endometriosis.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment