Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: An Intelligent Evaluation of Wrist Strength for the Elderly People and Its Clinical Application

Eligibility criteria:
Inclusion Criteria:

          -  Between 20 and 75 years old.

          -  No significant upper extremity joint pain or nerve palsy.(patients with tennis elbow
             typical of lateral elbow pain)

          -  Never received surgical treatment of upper limb joints

          -  No significant history of cardiovascular disease

        Exclusion Criteria:

          -  Significant disturbance of consciousness

          -  Unable to communicate with hearing and speech mode

          -  Lack of mental ability

          -  Emotional instability

          -  Significant systemic disease

          -  With upper limb joints or muscles, tendons obvious lesions
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Toward Better Outcomes in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis

          -  Moderate radiographic evidence by Kellgren and Lawrence grade 2-4

          -  Knee pain > 20 on VAS pain scale

        Exclusion Criteria:

          -  Bilateral knee replacements

          -  Unwillingness to take acetaminophen for pain relief
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Mulligan Mobilization With Movement Versus Macquarie Injury Management Group in Function and Pain of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  ACR criteria for knee will be over age 50 less than 30 minutes of morning stiffness,
             crepitus on active motion, Tenderness Enlargment No palpable warmth of synovium.
             Osteoarthritis grade 1 and 2 by Kelly-green and Lawrence method.

        Exclusion Criteria:

        - (a) Any surgical procedure done in past 6 months and metal implants in lower extremity.

        (b) Any infection and neoplastic disorder. (c) Post traumatic knee stiffnes. (d) Secondary
        knee OA peripheral vascular disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Prospective Study of an Human Endometrial Receptivity Test

Eligibility criteria:
Inclusion criteria :

          -  Infertile patients associated with multiple implantation failures.

          -  Signatures consent and non-opposition letter.

          -  Patients with a standard infertility assessment.

          -  Patients with a monitored cycle (ultrasound, hormonal markers) during the mock frozen
             embryo transfer cycle to perform the Win-test and during the embryo transfer cycle.

          -  Patients with complete treatment information during the mock frozen embryo transfer
             cycle to perform the Win-test and during the embryo transfer cycle.

          -  Patients with accurate transfer day information.

          -  Patients for whom we have the outcome (pregnancy, live birth).

        Exclusion criteria:

        More than 24 weeks of amenorrhea
Female
No healthy subjects accepted to join the trial.
Subject must be at least 27 Years old.
Subject must be at most 48 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC)

Eligibility criteria:
Inclusion Criteria:

          -  Patients eligible for enrollment will include all pediatric patients suffering from HD
             at an age of 12 months or younger. All patients will require consent by either parent
             or adult guardian

        Exclusion Criteria:

          -  Patients will be excluded if children that are deemed hemodynamically unstable and
             require immediate operative intervention, age more than one year of age, as this may
             mean very delay in diagnosis and may affect the study results, or infants having major
             congenital anomalies with short life expectancy. Additional exclusion criteria are
             those patients' parents or adult guardian who refuse to undergo randomization.
             Finally, those children who are transferred to another non-participating hospital will
             be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 12 Months

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Tomosynthesis Use in Detecting Subtle Occult Hip Fractures

Eligibility criteria:
Inclusion Criteria:

          -  Men and women aged > 18 years who/se:

          -  Present at the ER with a possible hip fracture and

          -  Have a negative x-ray for a hip fracture

          -  Physician has a high clinical suspicion of a hip fracture

          -  Provide provision of informed consent

        Exclusion Criteria:

          -  Hip prosthesis on the same side of the suspected hip fracture

          -  Other serious medical illness that is likely to interfere with study participation

          -  Significant psychiatric illness, senility, dementia, alcohol or substance abuse, which
             could impair the ability to provide informed consent and to adhere to the trial
             procedures

          -  Pregnant or suspected pregnancy
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed symptom history of heartburn, acid regurgitation, or epigastric pain of at
             least 3 months, while treating with gastric acid modulating therapy (antacids, H2
             receptor antagonists (H2RAs) and/or PPIs).

          -  Heartburn symptoms that average 3 times per week or greater including at least 2
             episodes of nighttime heartburn symptoms per week over the past 30 days.

          -  When heartburn medications were used, subject had heartburn symptoms that were
             responsive to antacids, non prescription H2RAs, or short term non prescription or
             prescription PPIs at approved doses but complete resolution of heartburn was not
             achieved.

        Exclusion Criteria:

          -  A history (past or present) of erosive esophagitis verified by endoscopy.

          -  The need for continuous treatment with H2RAs, PPIs, gastric prokinetic drugs, or
             antacids for any indication through the study (eg, long term prescription therapy).

          -  Subjects requiring continuous intervention by a physician for the treatment of GERD
             (ie, treatment of erosive esophagitis or prevention of relapse of healed esophagitis).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 22 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effects of Intra-uterine Slow-Release Insemination on Pregnancy Rate in Women Designated for Artificial Insemination

Eligibility criteria:
Inclusion Criteria:

          -  Primary or secondary infertility designated for IUI treatment.

          -  Age of candidates: 20-40 years.

          -  Normal uterus x-ray.

          -  Women suffering from infertility on a background of non-ovulation.

          -  Infertility on a background of male problems (over 10 million of motile sperm cells
             per sample).

          -  Infertility on background of unexplained problem

          -  Same sex patients / single patient

          -  Written informed consent

        Exclusion Criteria:

          -  Woman under the age of 20 or over the age of 40 years.

          -  Female infertility on mechanical background (different blockages, irregular uterus).

          -  Infertility on male background of medium to very low level of spermatozoa - less than
             10 million motile sperm cells per sample.

          -  Men and women who are opposed to the random spermatozoa insemination method.

          -  Participants who are not willing to sign the Consent Form.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: BAY14-2222 Continuous Infusion in Surgeries

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A (FVIII:C </=1%)

          -  No history of FVIII inhibitor formation and no current evidence of inhibitor antibody
             (Bethesda Assay < 0.6 BU)

          -  Elective major surgery requiring at least 6 days of rFVIII-FS therapy

          -  Subjects should have been previously treated with FVIII concentrates for at least 150
             exposure days. Previous treatment could have been with any type of rFVIII or with
             plasma-derived FVIII concentrate or cryoprecipitate

        Exclusion Criteria:

          -  Abnormal renal function (serum creatinine >1.3 mg/dL)

          -  Any treatments, which may change the clearance of FVIII (dialysis, plasma exchange)

          -  Anemia (hemoglobin <11 g/dL)

          -  Known AIDS (HIV seropositive patients may be enrolled)

          -  Active liver disease (transaminases > 5 times the upper limit of normal)

          -  History of severe reaction to FVIII concentrates

          -  Interferon treatment within the last 3 months

          -  Thrombocytopenia (< 100,000 platelets/mm3) or other known hematological/bleeding
             problems other than hemophilia A

          -  Intake of other investigational drugs within 1 month prior to study entry

          -  Need for pre-medication for FVIII infusions (e.g. antihistamines)

          -  Diastolic blood pressure >100 mm/Hg, which could not be controlled with
             antihypertensive medications
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction