Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: A Single Center Study to Evaluate the Penetration of RO7033877 Into the Lung in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Male or female healthy volunteers, 18 to 55 years of age, inclusive. A female
             participant is eligible to participate if she is of non-childbearing potential defined
             as postmenopausal or surgically sterile

          -  Healthy status is defined by absence of evidence of any active or chronic disease
             following a detailed medical and surgical history, a complete physical examination
             including vital signs, 12-lead electrocardiogram (ECG), hematology, blood chemistry,
             serology and urinalysis

          -  Body mass index (BMI) between 18 and 30 kg/m2 inclusive

          -  Nonsmokers

          -  Healthy male volunteers with female partners of childbearing potential must use
             adequate contraception methods

        Exclusion Criteria:

          -  Evidence of active chronic disease

          -  Regular consumption of drugs of abuse

          -  Infection with human immunodeficiency virus (HIV), hepatitis B (HBV), or hepatitis C
             (HCV)

          -  History of clinically significant hypersensitivity or allergic drug reactions

          -  Clinically significant abnormalities (e.g. cardiovascular, laboratory values)

          -  Abnormal blood pressure or vital signs

          -  Contraindications to bronchoalveolar lavage (BAL)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction