Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Value of Rapid on Site Evaluation During EBUS-guided TBNA in the Diagnosis of Mediastinal Lesions

Eligibility criteria:
Inclusion Criteria:

          -  Hilar/mediastinal lymph nodes with a short axis more than 1 cm on thoracic CT scan
             and/or PET-CT suspicious for malignancy with or without known lung malignancy.

          -  Hilar and/or mediastinal lymph nodes positive on PET/CT scan without regarding the
             diameter suspicious for malignancy.

          -  Recurrence or restaging of NSCLC after chemotherapy or radiation.

          -  Diagnosis of lung cancer when there is no endobronchial lesion.

          -  Diagnosis of both benign (especially tuberculosis and sarcoidosis) and malignant
             mediastinal lesions (eg. thymoma).

        Exclusion Criteria:

          -  Cardiovascular instability.

          -  Lack of patient cooperation, e.g. intractable cough, inability to remain motionless or
             altered consciousness.

          -  Bleeding diathesis (activated partial thromboplastin time (APTT) ratio or
             international normalized ratio (INR) <1.3 or platelet count of <50000 per mm3).

          -  Respiratory failure and patient on mechanical ventilation.

          -  Severe chronic obstructive pulmonary disease (COPD) (FEV1<1 liter or <35% predicted).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Study of FYU-981 in Hyperuricemia With or Without Gout

Eligibility criteria:
Inclusion Criteria:

          -  Hyperuricemic or gout patients

          -  Serum urate level:

        >= 7.0mg/dL in patients with history of gout, or >= 8.0mg/dL in patients with hypertension,
        diabetes or metabolic syndrome, or >= 9.0mg/dL

        Exclusion Criteria:

          -  Gouty arthritis within two weeks before start of study treatment

          -  Secondary hyperuricemia

          -  HbA1c: >= 8.4%

          -  Uric acid-overproduction type in the classification of hyperuricemia

          -  History of, clinically significant cardiac, hematologic and hepatic disease

          -  Kidney calculi or clinically significant urinary calculi

          -  eGFR: < 60mL/min/1.73m^2

          -  Systolic blood pressure: >= 180 mmHg

          -  Diastolic blood pressure: >= 110 mmHg
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Observatory of Patients With Chronic Lymphocytic Leukemia / Lymphocytic Lymphoma or Waldenstrom Disease Infected With COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of chronic lymphocytic leukemia / lymphocytic lymphoma or Waldenstrom
             disease according to the criteria of the WHO 2016 with a proven or probable infection
             by COVID-19 according to the following criteria:

          -  Proven infection: PCR positive regardless of the radio-clinical picture (Other tests
             made available later and having good diagnostic performance will be accepted)

          -  Probable infection: the diagnosis of probable infection is retained in case of
             negative PCR or not made if presence of at least 2 major criteria or of a major
             criterion associated with at least 2 minor criteria among the following, in the
             absence other documented cause.

          -  Major criteria:

               -  Fever

               -  Loss of smell / taste

               -  At least one respiratory sign among cough, dyspnea, chest pain

               -  Radiological signs suggestive of the scanner (areas or diffuse appearance of
                  frosted glass, condensations including pseudonodular condensations, association
                  of frosted glass and condensation within the same lesion, nodules and
                  micronodules, thickening of the interlobular septa) or on an X-ray of the thorax
                  ( interstitial, alveolo-interstitial or alveolar syndrome, unilateral or
                  bilateral)

               -  Notion of storytelling with a person whose SARS-CoV-2 infection has been formally
                  documented

          -  Minor criteria

               -  Aches

               -  Sore throat

               -  Rhinorrhea

               -  Headache

               -  Diarrhea

               -  Abdominal pain

               -  Frank asthenia

               -  Conjunctivitis

        Exclusion Criteria:

          -  Patient opposition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Fimasartan and Rosuvastatin for Hypertension and Dyslipidemia Control

Eligibility criteria:
Inclusion Criteria:

          -  Hypertension patients who are taking an anti-hypertensive agent, including Fimasartan
             at least 12 weeks or more.

          -  Dyslipidemia patients who are taking dyslipidemia drug, including Rosuvastatin at
             least 12 weeks or more

          -  Patients who has blood pressure and lipid levels (Total cholesterol, LDL-C, HDL-C,
             non-HDL-C, * TG) checks 2 weeks before registration

        Exclusion Criteria:

          -  Patients being hospitalized

          -  Patients who stop taking Fimasartan or Rosuvastatin within 12 weeks 14 or more
             consecutive days

          -  Patients who have more than 400mg/dl triglyceride(TG) at the registration time
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Effect of Electronic Cigarette Use on Cough Reflex Sensitivity

Eligibility criteria:
Inclusion Criteria:

          -  healthy adults (age18 years and above)

          -  nonsmokers

        Exclusion Criteria:

          -  previous smoker

          -  asthma/other respiratory illness

          -  acute viral upper respiratory tract infection (common cold) in previous 4 weeks
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: DECT Study in Allopurinol-Treated Gout Patients

Eligibility criteria:
Inclusion Criteria:

          -  Subject is able to understand the study procedures, the risks involved and willing to
             provide written informed consent before the first study related activity.

          -  Subject is willing to adhere to the visit/protocol schedules.

          -  Subject meets the diagnosis of gout as per the American Rheumatism Association
             Criteria for the Classification of Acute Arthritis of Primary Gout.

          -  Subject has been taking allopurinol at a dose of at least 300 mg daily for at least 12
             weeks prior to Day 1, as the sole uratelowering therapy.

        Exclusion Criteria:

          -  Subject who is pregnant or breastfeeding.

          -  Subject with any other medical or psychological condition, which in the opinion of the
             Investigator and/or Medical Monitor, might create undue risk to the subject or
             interfere with the subject's ability to comply with the protocol requirements
             (including dual energy computed tomography imaging), or to complete the study.

          -  Subject who has received an investigational therapy or has participated in any
             clinical trial or research study within 30 days of Day 1.

          -  Subject who has taken pegloticase (KRYSTEXXA®) or is expected to take pegloticase
             during the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Assessment of Skills and Behaviors in Children With Down Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Down syndrome childrens

          -  Age between 0 and 3 years

        Exclusion Criteria:

          -  Other physical or functional impairment that limits the performance of evaluation
No condition on gender to be admitted to the trial.


Subject must be at most 3 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Unilateral Meniere Disease: Can Double Dose Gadolinium and Delayed Imaging Make the Diagnosis?

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of unilateral Meniere Disease (MD) per the Committee on Hearing and
             Equilibrium of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)

          -  Glomerular filtration rate (GFR) > 90 mls/min/1.73 m2

          -  Creatinine (Cr) level serum < 1.6 mg/dl

        Exclusion Criteria:

          -  Age < 18 years

          -  Diagnosis of bilateral MD

          -  History of prior temporal bone surgery

          -  History of cochlear implant placement

          -  Pacemaker, cardiac implantable electronic device, shrapnel, aneurysm clips or other
             metal objects that are prohibited in the MR suite

          -  GFR < 90 mls/min/1.73m2

          -  Cr level > 1.6 mg/d

          -  Lack of IV access

          -  Contrast allergy to gadolinium agent

          -  Pregnancy

          -  Claustrophobia necessitating parenteral anxiolytics

          -  Patients who are unable to provide informed consent for themselves
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Cardiorespiratory and Muscular Rehabilitation of Children and Young Adults With Marfan Syndrome.

Eligibility criteria:
Inclusion Criteria:

          -  Marfan syndrome according to Ghent criteria.

          -  For minors, signed informed consent of at least one of the holders of the parental
             authority. For majors, signed informed consent.

          -  Patient affiliated to a social security scheme or equivalent.

        Exclusion Criteria:

        - Cardiac contraindications to Personal Training Program: O Severe aorta dilatation (aortic
        diameter> 45 mm) O and / or left ventricular failure (left ventricular ejection fraction
        <45%) O and / or severe mitral leakage ≥ grade 3

        - Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment