Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: The Spine Kinematics and Center of Pressure Excursion During Functional Task Vertebral Compression Fractures Subjects

Eligibility criteria:
Vertebral compression fracture Inclusion Criteria:

        older than 65 years osteoporosis diagnosed by a bone mineral density test of the lumbar
        spine (T-score < -2.5; T: peak bone mass) thoracic-lumbar VCF on radiography without
        displacement

        Vertebral compression fracture Exclusion Criteria:

        other spinal diseases that might also cause back pain (such as scoliosis, lumbar
        spondylolisthesis, lumbar disk disease, and spinal stenosis) a history of diabetes a
        history of neurological disease (such as cerebral vascular disease, peripheral neuropathy
        and vestibular disease).

        Control Inclusion Criteria:

        None the control participants had evidence of gait, postural, or spine disorders.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Evaluation, Treatment, and Follow-up of Patients With Lyme Disease

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Clinical diagnosis of active Lyme disease at the time of the initial NIH evaluation
             based on the CDC case definition. Study physician will review history to confirm
             probable cases.

          -  Subjects must maintain a private physician for non-protocol related medical complaints
             and for emergency medical treatment required for these or other of their disorders.

        EXCLUSION CRITERIA:

          -  Post treatment Lyme disease syndrome.

          -  Unacceptably poor compliance, which, in the opinion of the investigator, would
             interfere with one's ability to study or provide quality medical care for the patient.

        ELIGIBILITY CRITERIA TO UNDERGO APHERESIS:

          -  Age 18 years or above.

          -  Weight greater than 110 pounds.

          -  No known heart, lung, kidney disease, or bleeding disorders.

          -  Negative HIV, HCV and HBsAg serologies.

          -  Female subjects should not be pregnant or nursing.

          -  Patients will have a CBC performed up to 2 weeks before the procedure. In order to be
             able to undergo the procedure, patient must fulfill all of the below:

               -  Hemoglobin greater than 11 g/dL for males and greater than 10 g/dL for females.

               -  Platelets greater than 150 k/mm(3).

               -  WBC greater than 3.5 x 10(3) uL.

               -  MCV above 80.

        Women who are able to conceive children must have a negative pregnancy test within 2 weeks
        before the procedure.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Comparison of Hand Functions and Wrist Proprioception in Patients With and Without Psoriatic Arthritis

Eligibility criteria:
Inclusion Criteria:

          -  to be diagnosed according to CASPAR or ACR/ EULAR 2010 criteria for patient groups

          -  taking regular medication for patient groups,

          -  have complaints related to hand / wrist joints for patients groups,

          -  have no complaints related to upper extremity for asymptomatic healthy group.

          -  have any rheumatologic disease and OA diagnosed according to traditional criteria

        Exclusion Criteria:

          -  finger infection and / or finger amputation,

          -  using orthoses,

          -  to report a diagnosis of neurological disease,

          -  to report a history of trauma or surgery involving the upper extremity,

          -  to report a psychiatric and / or cognitive problem
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Biomechanical Analysis of Gait in Individuals With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of DMD

          -  Male.

          -  Four years of age or older.

          -  Ability to walk independently for five minutes to 10 minutes at self-selected speed.

          -  Ability to cognitively understand directions for testing procedures.

        Exclusion Criteria:

          -  Female

          -  Nonambulatory
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee osteoarthritis presenting to physician's office

          -  Radiographic evidence of knee osteoarthritis

          -  Age 18 years or older

          -  Failed minimum of 3 months of non-operative treatment, including, but not limited to,
             Tylenol, anti-inflammatory medication, cortisone injection, physical therapy, bracing,
             and/or heel wedge

          -  Symptoms for at least 3 months

        Exclusion Criteria:

          -  Associated ligamentous instability

          -  History of deep knee infection

          -  Candidate for total knee arthroplasty or arthroscopy

          -  Peripheral neuropathy.

          -  X-rays that are completely negative and only MRI evidence or arthroscopic evidence
             (from previous arthroscopy) of OA.

          -  Prior HA injections at any point in the past

          -  Chondrocalcinosis

          -  Patients with precautions or contraindications for viscosupplementation use

          -  Cortisone injection within past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  18-75 years old

          -  groin hernia repair

          -  written consent

          -  ASA 1-3

          -  BMI 18-35

        Exclusion Criteria:

          -  unable to communicate in Danish

          -  relevant drug allergy

          -  pain medication in the last 24 hours

          -  pregnancy

          -  alcohol or/and drug abuse

          -  daily opioid intake

          -  infection at injection site
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Dynamic 4DCT to Examine Wrist Carpal Mechanics

Eligibility criteria:
Inclusion Criteria:

          -  fluent in English, capacity to provide consent,

          -  over the age of 18 years old, with no previous injury to either hand or wrist

        Exclusion Criteria:

          -  pregnancy and presence of neurological disorders, rheumatoid arthritis or comorbid
             health conditions that preclude completion of study measures
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Optimization of VIM Targeting in Essential Tremor Surgery

Eligibility criteria:
Inclusion Criteria:

          -  Severe essential tremor despite the optimal medical management

          -  Age between 18 and 75 years

          -  Normal MRI scan

          -  Mattis Dementia Rating Scale (MDRS) score ≥ 130

          -  Affiliation to the social security

          -  Signed informed consent

        Exclusion Criteria:

          -  Depression (Beck Depression Inventory scale > 20)

          -  Contra-indication to surgery or general anesthesia

          -  Cerebral atrophy on MRI scan

          -  Pregnant or breastfeeding women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of DMD confirmed

          -  Ambulant

          -  Corticosteroid therapy for at least one year prior to study day 1 and on a stable dose
             and schedule for at least 6 months prior to study day 1

          -  Evidence of muscle weakness by clinical assessment

        Exclusion Criteria:

          -  Any previous treatment with another investigational product within 6 months prior to
             study day 1

          -  Any clinically significant cardiac, endocrine, hematologic, hepatic, immunologic,
             metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, renal, and/or
             other major disease that is not related to DMD

          -  Inability to perform a whole body dual x-ray absorptiometry (DXA) scan
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples

Eligibility criteria:
Inclusion Criteria:

          -  Males with no elongated spermatids or spermatozoa present but with round spermatids
             present on TESE (Testicular Sperm Extraction)

          -  Male diagnosed with non-obstructive Azoospermia

          -  Male partner ≥18

          -  Female partner greater than 18 years of age and less than 38 years of age or Anti
             Mullerian Hormone (AMH) greater than 2 ng/ml.

        Exclusion Criteria:

          -  Males with obstructive azoospermia

          -  Males with presence an adequate number of elongated spermatids or spermatozoa
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction