Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Multimodal Biomarkers for Diagnosis and Prognosis in CAA

Eligibility criteria:
Inclusion Criteria:

          -  ICH：

               1. Age：above 20 years old.

               2. Evidence of intraparenchymal hemorrhage on CT or MRI.

               3. Patient agrees to participate in the study and receive neurophsychological
                  examinations, genetic and biochemical markers test, MRI and PET imaging.

          -  AD：

               1. Age：above 20 years old.

               2. Patients who fulfills the clinical criteria of possible or probable Alzheimer's
                  disease (AD).51

               3. Patient agrees to participate in the study and receive neurophsychological
                  examinations, genetic and biochemical markers test, MRI and PET imaging.

          -  Control：

               1. Age：above 20 years old.

               2. Patient agrees to participate in the study and receive neurophsychological
                  examinations, genetic and biochemical markers test, MRI and PET imaging.

        Exclusion Criteria:

          -  ICH：

               1. patients with potential causes of hemorrhage including trauma, structural lesion,
                  brain tumor, or coagulopathy due to systemic disease or medication.

               2. Patients could not receive the PET and MRI studies, including but not limited to
                  poor cooperative agitation impeding adequate study, allergy to contrast medium,
                  hemodynamic instability, implantation of cardiac pacemaker, past history of
                  receiving aneurysm clipping, panic mood to MRI study, impaired kidney function.

               3. Patients with pregnancy or recently having a plan for pregnancy.

               4. Patients with breast feeding or recently having a plan for breast feeding.

               5. Patients with history of allergy to 11C-PiB and 18F-T807, or severe allergy
                  history.

               6. Patient or family who does not agree to participate in the study.

               7. patient with high risk by doctor evaluate.

          -  AD：

               1. Patients could not receive the PET and MRI studies, including but not limited to
                  poor cooperative agitation impeding adequate study, allergy to contrast medium,
                  hemodynamic instability, implantation of cardiac pacemaker, past history of
                  receiving aneurysm clipping, panic mood to MRI study, impaired kidney function.

               2. Patients with pregnancy or recently having a plan for pregnancy.

               3. Patients with breast feeding or recently having a plan for breast feeding.

               4. Patients with history of allergy to 11C-PiB and 18F-T807, or severe allergy
                  history.

               5. Patient or family who does not agree to participate in the study.

               6. patient with high risk by doctor evaluate.

          -  Control：

               1. History of neurological or psychiatric disease, abnormal neurological
                  examination.

               2. Patients could not receive the PET and MRI studies, including but not limited to
                  poor cooperative agitation impeding adequate study, allergy to contrast medium,
                  hemodynamic instability, implantation of cardiac pacemaker, past history of
                  receiving aneurysm clipping, panic mood to MRI study, impaired kidney function.

               3. Patients with pregnancy or recently having a plan for pregnancy.

               4. Patients with breast feeding or recently having a plan for breast feeding.

               5. Patients with history of allergy to 11C-PiB and 18F-T807, or severe allergy
                  history.

               6. Patient or family who does not agree to participate in the study.

               7. patient with high risk by doctor evaluate.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment