Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Safety and Efficacy Study of IGF-1 in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  DMD diagnosed with mutational testing and/or complete absence of dystrophin on muscle
             biopsy

          -  Proximal pelvic girdle weakness (Gower's maneuver, difficulty with arising from floor
             and going up steps)

          -  Male

          -  Age > 5 years of age

          -  Bone maturation (assess by bone age x-ray): </= 11 years of age

          -  Daily GC (prednisone or deflazacort) therapy for > 12 months

          -  Ambulatory

          -  Informed consent

          -  Willingness and ability to comply with all protocol requirements and procedures

        Exclusion Criteria:

          -  Current or prior treatment with growth hormone or IGF-1 therapy

          -  Non-ambulatory

          -  Pubertal (based on clinical Tanner staging examination)

          -  Congestive cardiac failure

          -  History of intracranial hypertension

          -  Daytime ventilatory dependence (non-invasive or tracheostomy)

          -  Concomitant therapy - any other medications/supplements that would be considered, in
             the opinion of the investigators, to affect muscle function, need to have been started
             3 months prior to enrollment

          -  Patients enrolled in other clinical drug trials

          -  Any physical or mental conditions which may, in the investigators'opinions, render the
             subject unable to complete the tasks of the study appropriately

          -  There will be no selection by ethnicity
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: TEP Versus Open Repair of Sportsman's Hernia

Eligibility criteria:
Inclusion Criteria:

          -  males/females professional or non-professional athletes

          -  age 18-50 years

          -  unilateral or bilateral groin pain lasting > 6 weeks

          -  physical examination and MRI indicating sportsman's hernia

          -  pain above inguinal ligament in the deep inguinal ring

          -  grade I-II edema at pubic symphysis on MRI scan is allowed

        Exclusion Criteria:

          -  patients not willing to participate

          -  inguinal or femoral hernia

          -  MRI reveals other major pathology

          -  former surgery to the actual groin

          -  allergy to polypropylene or other contra-indication to surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Use of COLD-fX to Prevent Respiratory Infections in Community Dwelling Seniors

Eligibility criteria:
Inclusion Criteria:

          -  Age 65 years of age and older

          -  current season influenza immunization

          -  available for follow-up visits

          -  willing and able to sign written informed consent

        Exclusion Criteria:

          -  HIV infection

          -  malignancy (under active observation or treatment)

          -  unstable cardiovascular diseases

          -  renal abnormalities (serum creatine >200umol/l)

          -  pulmonary disease (chronic bronchitis, emphysema, or asthma requiring treatment in the
             last 3 months with oral steroids - prednisone >10mg/day, other chronic respiratory
             illness)

          -  acute or active chronic liver disease

          -  neurologic or psychiatric disease (progressive or currently under treatment

          -  active tuberculosis

          -  multiple sclerosis

          -  bleeding disorders

          -  planned surgery over the course of the trial

          -  on immunosuppressive therapy

          -  taking oral steroids at dose = to prednisone 10 mg/day or more

          -  taking phenelzine, pentobarbital, haloperidol, warfarin, heparin

          -  use of natural health products(except the study product and vitamins and minerals with
             a dose <600 mg/day of vitamin E and containing no vitamin K) including echinacea or
             ginseng-containing products (tea, capsules, extracts, tablets)

          -  current alcohol/drug abuse

          -  major surgery in the past 6 months

          -  allergies to ginseng
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Depot Medroxyprogesterone Acetate as Emergency Contraception

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women of reproductive age (18-39 years old) with BMI 18-30 kg/m2

          -  Regular menses for the last 3 months

          -  Cycle duration 24 to 35 days

          -  Women using copper IUD, sterilization, or barrier methods as current or preferred
             birth control method, and women reporting exclusive sex with women

          -  English- or Spanish-speaking

        Exclusion Criteria:

          -  Any contraindications to progesterone contraception per teh CDC Medical Eligibility
             Criteria (Category 3 or 4)

          -  On medications that can alter, or be altered by, progesterone contraceptive steroid
             hormone (e.g., aminoglutethimide or other anti-steroid medication)

          -  Use of any hormonal contraceptive pill, patch, or vaginal ring in the month prior to
             recruitment

          -  Use of depot-medroxyprogesterone acetate in teh 10 months prior to recruitment

          -  Currently pregnant and/or breastfeeding

          -  History of allergic reaction to depot medroxyprogesterone acetate (rash, urticaria,
             anaphylaxis)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Subcapsular Orchiectomy in Men With Klinefelter Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Klinefelter

          -  15-40 years of age

        Exclusion Criteria:

          -  inability to understand the study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Acceptability, Feasibility and Preliminary Impact of OurPlan, an mHealth HIV Prevention Intervention for Male Couples

Eligibility criteria:
Inclusion Criteria for both partners of the male couple:

          -  self-reported that currently self-identifies as a male

          -  self-reported in a sexual relationship with another self-identified male

          -  self-reported relationship length between 1 and 12 months

          -  self-reported anal sex with relationship partner in past 2 months

          -  owns and uses an Internet-connected smartphone or tablet

          -  resides in the U.S.

          -  self-reported ability to read and understand English-language

        Exclusion Criteria:

          -  Does not meet one or more the inclusion criteria
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Nutritional Stimulation of Growth in Children With Short Stature Without Growth Hormone Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Ages 3 to 11 years (inclusive).

          -  Must have had normal growth hormone (GH) response (i.e., peak GH concentration ≥10
             ng/mL) to GH provocative tests such as Arginine Insulin Tolerance Test (AITT) or
             Arginine Clonidine Tolerance Test (ACTT).

          -  Pre-pubertal status (i.e. Tanner stage 1 for breast development for girls and
             testicular enlargement for boys and pubic hair for both sexes).

        Exclusion criteria:

          -  Ages younger than 3 years or older than 11 years.

          -  Medical history of a neurologic, endocrinologic, genetic, or metabolic problem known
             to have a direct effect on height growth. This includes, but is not limited to,
             children with Down syndrome, Turner syndrome, Russel-Silver syndrome, Prader-Willi
             syndrome, Pseudohypoparathyroidism, chronic kidney disease, malabsorptive syndromes,
             cancer survivors, etc.

          -  Currently being treated or previously treated with Growth hormone, or history of oral
             steroid treatment within the last 3 months.

          -  Being in puberty.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Characteristics of Patients and Healthcare Workers With COVID-19 in Meta State, Colombia

Eligibility criteria:
Inclusion Criteria:

          -  Patients admitted to participant institutions with respiratory symptoms or diagnosed
             as compatible with COVID-19.

        Exclusion Criteria:

          -  None.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 120 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Sensitivity and Specificity of Color Doppler Directed Temporal Artery Biopsy as Compared to Standard Random Biopsy in the Diagnosis of Temporal Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from signs and symptoms consistent with TA and who have not
             undergone previous temporal artery biopsy will be included.

        Exclusion Criteria:

          -  Patients suffering from isolated polymyalgia rheumatica will be excluded.

          -  Patients who are already undergoing steroid treatment will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)

Eligibility criteria:
Inclusion Criteria:

          -  Willing to self-identify an ethnic group, such as Caucasian, Asian, Afro-Caribbean.

          -  Have a firm clinical diagnosis of GCA or PMR, or (for patients identified
             prospectively) GCA or PMR should be more likely than any alternative explanation for
             the patient's symptoms.

          -  Able and willing to give informed consent. Patients will be 50 years of age or over,
             unless both biopsy-proven and a clinically classical case of GCA.

        Exclusion Criteria:

        • Patient unwilling or unable to give fully informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Wrist Arthroscopy Study

Eligibility criteria:
Inclusion Criteria:

          1. Age > 18 years.

          2. Wrist pathology based on clinical examination/imaging studies undergoing wrist
             arthroscopy for further evaluation/treatment.

          3. Willingness to participate in the study

        Exclusion Criteria:

          -  1. Age < 18 years.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment