Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography

Eligibility criteria:
DMD-Patients

        Inclusion Criteria:

          -  Histologic or genetically proven DMD

          -  Age 3-10 years

        Exclusion Criteria:

        -

        Healthy controls

        Inclusion Criteria:

          -  Male

          -  Age 3-10 years

        Exclusion Criteria:

          -  Suspected muscular disease/myopathia

          -  missing informed consent
Male
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203

Eligibility criteria:
Inclusion Criteria:

          -  Successful completion of ZA-203

          -  Ability to understand and provide written informed consent

          -  Agreement to use a condom, and with a fertile female partner, another form of
             contraception

          -  Agreement to provide semen samples in the clinic

        Exclusion Criteria:

          -  Any condition which, in the opinion of the Investigator, would make the Subject an
             unsuitable candidate for enrollment in the study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study of Meloxicam Capsules to Treat Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  Primary diagnosis of Functional Class I-III OA of the hip or knee

          -  Chronic user of nonsteroidal anti-inflammatory drugs (NDAIDs) and/or acetaminophen for
             OA pain

          -  Discontinued all analgesic therapy at Screening

          -  For women of child-bearing potential: a woman who is not pregnant and not nursing, and
             who is practicing an acceptable method of birth control

        Exclusion Criteria:

          -  History of allergic reaction or clinically significant intolerance to acetaminophen,
             aspirin, or any NSAIDs, including meloxicam

          -  Requires continuous use of opioid or opioid combination products to control OA pain of
             the knee or hip

          -  Clinically significant unstable cardiac, respiratory, neurological, immunological,
             hematological, or renal disease

          -  Significant difficulties swallowing capsules or unable to tolerate oral medication

          -  Previous participation in another clinical study of Meloxicam Capsules or received any
             investigational drug or device or investigational therapy within 30 days before
             Screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy

Eligibility criteria:
Group 1:

        HCM patients, aged grater than 20 years of either gender who received DDD pacemakers at the
        NIH at least 4 years ago, for relief of LVOT obstruction and drug-refractory symptoms.

        Group 2:

        HCM patients selected from Group 1 who at the follow-up cardiac catheterization are
        demonstrated to have either (1) no significant LVOT obstruction (less than 30mm HG at rest
        and less than 50mm HG with Isuprel); or (2) a substantial reduction of the LVOT obstruction
        (greater than 50% reduction in LVOT gradient).

        Patient who have developed a heart block will be excluded from group 2.

        Females must have a negative pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Cryotherapy Associated With Exercise in Pain Control and Physical Function in Individuals With Knee Osteoarthritis

Eligibility criteria:
Main Inclusion Criteria:

          -  Diagnosed with knee osteoarthritis based on clinical and radiographic criteria of
             American College of Rheumatology

          -  Grade 2 or 3 according to the criteria of Kellgren & Lawrence knee osteoarthritis
             radiographic examination scale.

          -  Minimum score of 4 cm in Visual Analogue Scale (total 10 cm)

          -  Medical prescription, showing that the participant is capable of performing physical
             activities

        Main exclusion Criteria:

          -  Physical therapy within 3 months prior to the research project

          -  Corticosteroid injection in the knee (in the previous 6 months)

          -  Medical condition (cardiorespiratory, neurological and / or musculoskeletal)

          -  Previous ankle, knee or hip surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Lansoprazole for Subgroups of Functional Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  Dyspeptic adult outpatients

          -  Characteristic dyspeptic symptoms according to Rome III criteria (bothersome
             postprandial fullness, early satiation, epigastric pain, or epigastric burning)

          -  Upper gastrointestinal endoscopy excluding structural diseases

        Exclusion Criteria:

          -  aged less than 20 years old,

          -  organic lesions such as peptic ulcer, tumor of any kind, stricture or structural
             deformity, erosive esophagitis, or vasculopathy on endoscopy

          -  typical and predominant reflux symptoms (heartburn or acid regurgitation)

          -  comorbidity with malignancy, diabetes mellitus, liver cirrhosis, renal failure, or
             porphyria

          -  history of intra-abdominal surgery

          -  concurrent use of aspirin, non-steroidal anti-inflammatory drug or proton pump
             inhibitor

          -  history of allergy or severe side effects to lansoprazole

          -  pregnant or lactating women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Relief From Side Effects: Clinical Use of Electrodes With Direction

Eligibility criteria:
Inclusion Criteria:

          -  Participants must have been implanted with the DBS

          -  Participants must have been diagnosed with Essential Tremor

          -  Participants must experience negative side effects from their DBS which limit control
             over their tremor

          -  Participants must be able to receive benefit from their stimulator, but at the cost of
             negative side effects

        Exclusion Criteria:

          -  All individuals who meet criteria outlined in "inclusion criteria" may be eligible for
             this study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Regression of Hamstring Flexibility and Performance in Children With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  To be a Duchenne Muscular Dystrophy diagnosis,

          -  Being in the ambulatory period and climbing four steps independently,

          -  to be Level 1 and Level 2 according to Brooke Lower Functional Classification Test

          -  To be able to cooperate

          -  No any severe contracture in the lower limbs which may prevent assessments,

        Exclusion Criteria:

          -  Children who fail to meet these criteria study.
Male

Subject must be at least 5 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected
             to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2
             major criteria and at least one minor criteria.

        Major criteria : Age > 50 ans ; headache ; intermittent jaw or tongue pain ; visual
        impairment ; ESR > 50 mm at 1h and/or CRP > 8mg/l.

        Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever
        >38°C, weight loss >10%, anorexia, fatigue.

        Exclusion Criteria:

          -  Autoimmune disease

          -  Active infectious condition

          -  Malignant disease

          -  Condition counterindicating one or several of the protocol's imaging procedures :
             allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic
             foreign body...
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of ALS

          -  Taiwanese and used traditional Chinese(Mandarin).

          -  If they were older than age 20 years.

        Exclusion Criteria:

          -  Frontotemporal dementia, severe depression, or schizophrenia.

          -  If they cannot complete the questionnaire with researchers or family members help.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment