Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age

Eligibility criteria:
Inclusion Criteria:

          -  Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the
             center of language and learning disorders at Raymond Poincaré hospital;

          -  With severe learning disorders: deficiency in school work, need at least one medical
             appointment and long-term rehabilitation in the center of language and learning
             disorders at Raymond Poincaré hospital;

          -  Affiliated to a social protection schema;

          -  Written informed consent signed.

        Exclusion Criteria:

          -  Absence of learning disorder;

          -  Intellectual deficiency;

          -  Epilepsia;

          -  Patients who will performed follow-up at Chartres city;

          -  Patients under guardianship or curatorship;

          -  Foreign patients under AME schema, a medical help from the state in France.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Entailment