Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Syncope Patient Evaluation in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  (near) syncope

        Exclusion Criteria:

          -  age < 18 years

          -  progressive impairment of consciousness

          -  use of mind-altering drugs

          -  non syncopal loss of consciousness: hyperventilation, hypoglycaemia, metabolic
             disorders, psychogenic pseudosyncope, TIA or stroke, seizure, transient loss of
             consciousness caused by craniocerebral injury
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Stimulate Brain and Reduce Knee Pain Due to Degeneration

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with clinical knee OA according to the diagnostic criteria of ACR
             were included in the study

        Exclusion Criteria:

          -  Unwillingness to participate in the study

          -  Recent history (within the last 3 months) of physical therapy to the same joint

          -  Recent history (within the last 3 months) of intra-articular procedure (injection
             and/or lavage) to the knee

          -  History of knee surgery/fracture

          -  Acute synovitis/arthritis including the infectious conditions

          -  Taking pain relief medications

          -  Any metal implantation near site of stimulation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Effects of Age and Age-Related Diseases on Swallowing

Eligibility criteria:
Inclusion Criteria:

        Age of 65 or older, MD determined medical stability, referred by MD for swallowing
        evaluation because of suspected dysphagia, confirmed dysphagia by x-ray evaluation,
        geographic access to return for clinic appointments, telephone in home, ability to perform
        exercises, capacity to provide informed consent, frailty defined by Winograd et al

        Exclusion Criteria:

        Admitted from a nursing home after a longer than 3 month stay, previously enrolled in this
        study, not able or willing to return for outpatient visits, unable to complete telephone
        interviews, cerebrovascular accident within 90 days, medically unstable as determined by
        MD, claustrophobia, known contraindications to MR imaging (e.g., pacemaker, aneurysm clip),
        more than 2 dental crowns, poorly controlled psychosis, refractory alcoholism, other severe
        disabling diseases resistant to medical management (e.g., class IV congestive heart
        failure, end stage renal disease), allergy to barium, terminally ill (predicted survival
        less than 6 months)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Cushing's Lipodystrophy

Eligibility criteria:
Inclusion Criteria:

          1. Aged 18-70 yrs

          2. Body mass index (BMI) <35 kg/m2

          3. Urine free cortisol (UFC) ≥150ug/d

          4. Pituitary tumor >6mm on MRI or an inferior petrosal sinus sampling with central to
             peripheral plasma adrenocorticotropic hormone (ACTH) gradient

          5. Normal renal and thyroid function

          6. HbA1c ≤8.0.

        Exclusion Criteria:

          1. Smoking

          2. Alcohol >2 drinks/day

          3. Uncontrolled hypertension

          4. HIV given potential for lipodystrophic confounding

          5. Pregnancy and nursing

          6. Use of beta-blockers, β-adrenergic or diabetes medications other than insulin

          7. History of claustrophobia or difficulty lying flat

          8. In-dwelling metal hardware.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: The Role of Igf-1 Generation Test in Diagnosis and Treatment of Short Stature

Eligibility criteria:
Inclusion Criteria:

          -  ability to provide written informed consent

          -  Prepubertal males and females form 5- 11years old

          -  Bone age <11 years in males and <9 years in females

          -  Height SD score<-2.25SD in males and females

          -  IGF-1SD score <-1SD in both males and females

          -  Peak GH level after stimulation >10ng/ml

        Exclusion Criteria:

          -  History of prior chemotherapy and or radiation

          -  Active neoplasm

          -  Pediatric patients with closed epiphyses

          -  Prader-Willi syndrome, Turner syndrome or any other genetic or chromosomal anomaly

          -  Treatment with inhaled or systemic steroids

          -  BMI <5th percentile or >95th percentile

          -  Tanner 2 at clinical or biochemical examination by ultrasensitive LH and FSH
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Measurement and Prediction of Outcomes of Amplification

Eligibility criteria:
Hearing-impaired patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Immune and Scfa Profile of Stunting Children

Eligibility criteria:
Inclusion Criteria:

          -  Children age : 3 - 5 years old (36-60 months)

          -  Live in the research area

          -  Apparently healthy children, after examination by a physician

          -  Involved in a research study (informed consent signed by parent or guardian)

        Exclusion Criteria:

          -  Children age < 36 month and > 60 month

          -  Live outside research area

          -  Unhealthy, after examination by a physician
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 5 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Transferrin Saturation and Asthenia in Hemochromatosis

Eligibility criteria:
-  Inclusion criteria:

               -  homozygous C282Y ;

               -  in the maintenance phase for at least 6 months ;

               -  follow-up at Rennes University Hospital ;

               -  patient who has not expressed his opposition to participate in the study.

          -  Exclusion criteria:

               -  Permanent: any cause of modification of the CST unrelated to hemochromatosis
                  (chronic inflammatory disease, excessive consumption of alcohol ...) ;

               -  Temporary: infectious syndrome within 7 days before bleeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Norplant and Irregular Bleeding/Spotting

Eligibility criteria:
Inclusion Criteria

          -  Regular menstrual periods for the last 2 cycles

          -  Currently not using hormonal contraceptives, including oral contraceptives, patch,
             ring, or Norplant in 2 months prior to study entry, or Depo-Provera in 12 months prior
             to study entry

          -  Currently not using tetracycline-class antibiotics

          -  Normal Pap smear

        Exclusion criteria

          -  Pregnancy or breastfeeding within 2 months of study entry

          -  Chronic migraine headaches

          -  Uncontrolled high blood pressure

          -  Untreated sexually transmitted diseases

          -  Alcoholism or drug abuse within 12 months of study entry

          -  Insulin dependent diabetes

          -  Liver, kidney, or gallbladder disease

          -  Participation in another clinical trial within 30 days of study entry

          -  History of cancer

          -  History of blood clots, strokes, or heart disease
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Pain Sensitization and Outcome Following Physiotherapy in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis diagnosed by American College of Rheumatology clinical criteria

          -  Knee pain must be the primary musculoskeletal complaint participant is seeking
             treatment for

          -  Pain duration greater than 3 months

          -  Pain severity ≥ 5/10 on Numerical Rating Scale

          -  Willing to abstain from simple analgesics and NSAIDs for 24 hours prior to testing

          -  Willing and able to give full consent

        Exclusion Criteria:

          -  Lumbar or cervical radiculopathy,

          -  Systematic inflammatory disease,

          -  Positive screen for diabetic neuropathy

          -  Past medical history

          -  Previous surgery or disease of the peripheral or central nervous system,

          -  Sensory loss secondary to chemotherapy or radiotherapy

          -  Fibromyalgia

          -  Chronic fatigue syndrome

          -  Cognitive or psychiatric disorder interfering with ability to cooperate with
             assessment

          -  Injection or physiotherapy treatment for knee joint within previous 3 months

          -  Taking anti-depressant or anti-convulsant medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction