Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          1. Appropriate degree of weakness for age, creatine kinase greater than 20 times the
             upper limit of normal, and genetic mutation known to be causative for Duchenne
             muscular dystrophy .

          2. Appropriate degree of weakness for age, creatine kinase greater than 20 times the
             upper limit of normal and genetic or biopsy confirmation of Duchenne muscular
             dystrophy in a primary relative (e.g. brother or maternal uncle).

          3. De-identified, genetic studies will be reviewed by collaborator Kevin Flanigan, MD
             prior to enrollment of subjects.

          4. Age at entry: one month through 30 months.

        Exclusion Criteria:

          -  Prior treatment with corticosteroids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 30 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Characteristics and Health Related Quality of Life in Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  Idiopathic Pulmonary fibrosis will be diagnosed by presence of UIP pattern. Other
             forms of ILD will be diagnosed using HRCT by presence of Reticular abnormality
             Honeycombing with or without traction Extensive ground glass abnormality.

          -  Profuse micronodules.

        Exclusion Criteria:

          -  Patients who refused to participate in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Pulmozyme for Sjogren's Associated Cough

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or above with primary Sjogren's disease (as defined by the American
             European Consensus Group Criteria), and complaint of chronic cough.

          -  Able to give consent and anticipated ability to adhere to the study procedures.

        Exclusion Criteria:

          -  Diagnosis of COPD, emphysema, asthma, chronic bronchitis, other clinically significant
             lung disease that is likely to cause cough. Interstitial lung disease associated with
             Sjogren's is not excluded.

          -  Cigarette use of greater than 20 pack years or regular use within 6 months

          -  Allergy or intolerance to Pulmozyme.

          -  Acute respiratory infection or other acute respiratory illness during the prior month.

          -  LCQ greater than 17 and VAS less than 3 cm at baseline (Visit 1).

          -  Pregnancy or breast feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Adults with Osteoarthritis:

          -  Age 50-80

          -  radiographic evidence of knee osteoarthritis (OA participants)

          -  self-report current non-smoker

          -  willing and able to walk for 30 minutes a day three days a week for six weeks at a
             location that is within 30 minutes from University of Maryland Baltimore

          -  speaks English

        Healthy Controls:

          -  Age 50-80

          -  self-reports no osteoarthritis

          -  self-report current non-smoker

          -  willing and able to walk for 30 minutes a day three days a week for six weeks at a
             location that is within 30 minutes from University of Maryland Baltimore

          -  speaks English

        Exclusion Criteria:

          -  unable to pass the evaluation to sign consent

          -  diagnosis of rheumatoid arthritis

          -  diagnosis of gout

          -  diagnosis of heart failure

          -  diagnosis of chronic obstructive pulmonary disease

          -  diagnosis of diabetes

          -  diagnosis of Parkinson's disease

          -  diagnosis of Alzheimer's disease

          -  diagnosis of autoimmune disease

          -  currently taking long-term steroid medications such as methotrexate

          -  weight less than 110 lbs.

          -  direct employee of the PI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Alzheimer's Disease Reminiscence Quality of Life

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimer's disease

          -  Able to communicate

        Exclusion Criteria:

          -  Active major psychiatric disorders

          -  Acute or unstable chronic medical conditions

          -  Blindness

          -  Deafness
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 87 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Greater than 18 of age

          -  Meet the diagnostic criteria for essential tremor with visible upper limb tremor

          -  Must be either on stable medications to treat tremor for 30 days, or no medications to
             treat tremor

        Exclusion Criteria:

          -  History of seizures

          -  History of chronic pain conditions

          -  Any metal in their body above their shoulders

          -  Use of medications that lower seizure threshold including:

               -  broad classes of drugs such as tricyclic antidepressants

               -  anti-psychotics

               -  neuroeptics

               -  thyroid medications and stimulants

          -  Use of any medications that cause tremor, Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          1. Patients aged 18 years or older with moderate to severe knee effusion associated with
             underlying osteoarthritis (Outerbridge grade II or higher) that undergo therapeutic
             aspiration

          2. Patients with symptomatic primary total knee arthroplasty without infection (as
             verified by prior aspiration) with moderate to severe effusion electing for
             therapeutic arthrocentesis. Must be minimum of 3 months from index surgery to be
             included.

        Exclusion Criteria:

          1. Patients with effusion related to trauma or another underlying condition (ie.
             fracture, ligamentous injury, hemarthrosis)

          2. Patients with known history of gout or with synovial fluid samples testing positive
             for urate of calcium pyrophosphate crystals

          3. Patients with knee effusion associated with septic arthritis or periprosthetic knee
             infection as determined from knee arthrocentesis.

          4. Patients with inflammatory arthritis (ie. JIA, RA, psoriatic arthritis, etc).

          5. Patients with revision knee arthroplasty, unicompartmental arthroplasty or other
             repair/reconstruction surgery

          6. Patients with underlying muscular disorder (ie. Stroke, cerebral palsy, multiple
             sclerosis, polymyalgia, fibromyalgia, muscular dystrophy, etc.)

          7. Patients with symptomatic hip pain

          8. Patients with active cancer in the area

          9. Patients with pacemakers

         10. Patients who are pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Constitutional delay of growth and puberty

          -  Age 14 years or more

          -  mean testicular volume 2.5 ml or more and less than 4 ml

          -  serum testosterone level less than 5 nM OR

        as above, but serum testosterone 1 nM or more with normal DHEAS level, even if the mean
        testicular volume is less than 2.5 ml OR

        as above, but tanner stage G2 and testosterone level less than 3 nM

        Exclusion Criteria:

          -  Chronic diseases

          -  Primary or secondary hypogonadism

          -  Chromosomal anomalies

          -  Chronic medication that potentially adversely affects bone mineralization (excluding
             inhaled corticosteroid treatment)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Strategies for Patients With Osteoarthritis, by Using Assistive Technology and Exercises.

Eligibility criteria:
Inclusion Criteria:

          -  Kellgreen and Lawrence (KL) classification for I to III or painful IV osteoarthritis
             (with the use of orthoses for analgesia, in this case).

          -  Capacity to understand and agree to the consent form and questionnaires and
             evaluations.

        Exclusion Criteria:

          -  Patients who had undergone previous non-medical therapeutic treatment for OA of the
             hands;

          -  Who had undergone some surgical procedure in the region or were involved in another
             clinical trial;

          -  Patients with rheumatoid arthritis or other rheumatologic disease, any neurological
             problems.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux

Eligibility criteria:
Inclusion Criteria:

          -  history of obesity exceeding 5 years

          -  documented previous weight loss attempts,

          -  body mass index (BMI)) of 40-50 kg/m2

          -  age of 18-60 years.

        Exclusion Criteria:

          -  contraindications to pneumoperitoneum

          -  large esophageal hiatal hernia

          -  pregnancy,

          -  drug or alcohol abuse,

          -  psychological disorders (e.g., bulimia, depression)

          -  hormonal or genetic obesity-related disease

          -  previous gastric surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction