Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy

Eligibility criteria:
Inclusion Criteria:

          -  Over 18 years and below 75 years of age

          -  Plan to undergo MCCG examination in Changhai Hospital

        Exclusion Criteria:

          -  dysphagia or symptoms of gastric outlet obstruction, suspected or known intestinal
             stenosis, overt gastrointestinal bleeding, fistulas and strictures;

          -  history of gastrointestinal surgery or suspected delayed gastric emptying;

          -  Implanted metallic devices such aspacemakers, defibrillators, artificial heart valves
             or joint prostheses;

          -  Allergic to high molecular materials such as simethicone and streptozyme;

          -  Pregnancy or mentally ill person;

          -  currently participating in another clinical study;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Real World Evidence for the Cycle of Neoadjuvant Chemotherapy in Gastric Cancer With Shared Decision Making

Eligibility criteria:
Inclusion Criteria:

          1. Histologically proven adenocarcinoma of the stomach

          2. Clinical cT2N+M0,or cT3-4a/N+M0 disease, confirmed by upper gastrointestinal endoscopy
             and abdominal computed tomography (CT) and MRI and laparoscopy.

          3. Receive neoadjuvant chemotherapy in clinical

        Exclusion Criteria:

          1. Contraindication for chemotherapy

          2. Contraindication for surgery

          3. Clinically apparent distant metastasis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Follicle Stimulating Hormone (FSH) to Improve Testicular Development in Men With Hypogonadism

Eligibility criteria:
Inclusion Criteria

          -  no history of spontaneous puberty

          -  clinical hypogonadism

          -  infantile testes (< 3 ml)

          -  no reproductive hormone therapy except testosterone

          -  Complete absence of normal LH pulses during 12-hour baseline frequent blood sampling
             and serum testosterone < 100 ng/dl

          -  Normal testing of the anterior pituitary gland

          -  Negative MRI of the hypothalamic-pituitary area

        Exclusion Criteria

          -  Prior therapy with gonadotropins (FSH, hCG, or GnRH)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Feasibility of Re-TREPP in Patients With a Recurrent Inguinal Hernia After Previous TREPP Repair

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients who had developed a recurrent inguinal hernia and had undergone a
             re-TREPP.

        Exclusion Criteria:

          -  Children (age <18 years)

          -  Exclusion criterium for long term follow up: no informed consent obtained.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Non-Invasive Electrical Stimulation of the Human Brain

Eligibility criteria:
Males and females, ages 18 and over.

        Diverse racial groups.

        Amputees and others with whom we will have no patient-care relationship may also be
        considered to be volunteers.

        Patients will be recruited from those referred to the Human Motor Control Section, NINDS
        who have neurological syndromes that are of interest.

        On rare occasions we may attempt to study children as young as 10 years with TES.

        Individuals without indwelling cardiac lines and pacemakers.

        Patients recruited for study would come from those referred to the EMG laboratory and to
        the Human Motor Control Clinic who would have distinct neurologic syndromes from well
        defined peripheral and central nervous system lesions including hemiplegia from stroke,
        trauma, tumor or focal demyelination (most commonly patients would have hemiplegia from
        stroke), peripheral nerve lesions, amputations, spinal cord injury.

        Normal volunteers, including NIH employees, would be healthy adults without history of
        physical examination evidence of neurologic disease and individuals with different types of
        amputations involving upper and lower extremities.

        Volunteers may also be participants in the electrophysiological protocol (84-N-0196).

        No history of epilepsy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluation of a Simple Pharmacokinetic Tool (myPKFiT™) to Guide Personalized Factor VIII Dosing in Patients With Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of Hemophilia A;

          -  Severe disease (FVIII <2%);

          -  Receiving ADVATE for prevention of bleeding (prophylaxis) or receiving ADVATE on
             demand and a candidate for prophylaxis;

          -  Body weight ≤120 kg; and ≥12kg;

        Exclusion Criteria:

          -  FVIII inhibitor positive (level of ≥0.6 Bethesda Units [BU] per mL using the Nijmegen
             modification of the Bethesda assay). Inhibitor status to be documented as negative
             prior to study enrollment according to the two most recent, consecutive inhibitor
             assays on record. If patients have < 50 exposure days, an assay will be completed
             centrally within a reasonable timeframe (approximately 8 weeks suggested) to make sure
             that they are negative.

          -  Body weight >120 kg or <12kg;

          -  Human immunodeficiency virus (HIV) positivity with cluster of differentiation 4 (CD4)
             count < 200 / microliter;

          -  Significant hepatic dysfunction, alanine aminotransferase (ALT) or aspartate
             aminotransferase (AST) >5 times upper limit of normal

          -  History of recent events that might affect FVIII half-life (e.g., infection, surgery
             or an invasive procedure) within 2 weeks of blood sampling.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Social Cognition and Turner Syndrome

Eligibility criteria:
Inclusion criteria:

          -  Turner syndrome with homogeneous 45,X karyotype.

          -  Age between 8 and 18 years.

          -  Somatic state compatible with the evaluation.

          -  Functional language and IQ ≥ 80 for the transfer tests

          -  Informed consent signed by the holders of parental authority, the patient and the
             mother for her own participation (DNA collection).

          -  Affiliation to Social Security (beneficiary or assignee).

        Exclusion Criteria:

          -  Additional condition associated with an autism spectrum disorder

          -  Turner syndrome not related to an homogeneous 45,X karyotype
Female
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Marfan Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Individual with Marfan syndrome consented in to the Main Atenolol Vs. Losartan NIH
             study.

        Exclusion Criteria:

          -  Subjects in the main PHN Marfan trial who have not achieved the maintenance drug
             dosing or who have stopped taking study drug.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 24 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The Effect of Auricle Position on Tympanic Thermometry

Eligibility criteria:
Inclusion Criteria:

        The patients who were 18 years old or older, conscious, without communication issues,
        volunteers, not diagnosed with otitis media, who did not have a fever.

        Exclusion Criteria:

        havin fever, Being under the age of 18, not volunteers.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Dating Violence and HIV Prevention in Girls: Adapting Mental Health Interventions

Eligibility criteria:
Inclusion Criteria:

          -  Adolescent must be English-speaking

          -  Adolescent must have a lifetime history of physical dating violence perpetration or
             victimization

        Exclusion Criteria:

          -  Current enrollment in an intervention for dating violence or HIV prevention
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Epigenetic Tools as Prognostic Predictors in Covid19

Eligibility criteria:
Inclusion Criteria:

          -  All patients between the ages of 18 and 65 included will suffer from COVID 19, and
             specific treatment should not yet be initiated.

          -  COVID 19 diagnosis of patients will be based on full medical history, thorough
             clinical examination, radiological imaging, laboratory assessment, and SARS-CoV-2
             analysis by RT-PCR.

        Exclusion Criteria:

          -  People with chronic lung disease or previous AC surgery

          -  People with immune deficiency or cancer patients

          -  Patients receiving immunosuppressive therapy for autoimmune disease

          -  People with neurological diseases affecting the respiratory muscles, such as
             hypotonia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment