Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Evaluation of the Antalgic Effect of Puressentiel Joints and Muscles - Gel on Joint Pain of the Knee

Eligibility criteria:
Inclusion Criteria:

          -  Subject smust be able to understand the terms of the written informed consent and must
             agree to date and sign it before any study procedure is carried out,

          -  Patient having signed the informed consent

          -  Aged 45 to 90

          -  With chronic osteoarthritis of the knee

          -  Patient with or without analgesic and anti-inflammatory treatment

        Exclusion Criteria:

          -  Patient at the stage of surgical osteoarthritis (grade 4 plus limitation of amplitude)

          -  Patient with a limited walking perimeter (<100m) for any reason whatsoever

          -  Patient allergic to one of the components of the study product

          -  Patient not benefiting from social security

          -  Patient cannot be followed for the duration of the study

          -  Participation in another clinical trial within 30 days before V0

          -  Subjects who cannot understand or perform study procedures.

          -  Pregnant or breastfeeding women

          -  People with a history of convulsive or epileptic disorders

          -  People allergic to salicylates.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications.

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 18 years old

          -  Patients seen in the psychiatry department requiring the prescription of psychotropic
             drugs (antidepressants anxiolytics) for over 6 weeks

          -  Patients complaining of xerostomia

          -  Patients having not taken a palliative therapy against xerostomia for at least 2 weeks

          -  Patients having signed a free and informed consent form

          -  Patients affiliated to a social security system

        Exclusion Criteria:

          -  Patients suffering from psychotic illness

          -  Patients suffering from Sjogren's syndrome

          -  Patients having been treated by radiation therapy for head or neck cancer

          -  Patients having stopped a palliative therapy against xerostomia for less than 2 weeks

          -  Patients under 18

          -  Pregnant or Breastfeeding women

          -  Incapacitated adults

          -  Patients placed under tutorship or curatorship

          -  Patients under judicial protection

          -  Patients suffering from milk allergy or lactose intolerance
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Exercise and Prevention of Syncope: EXPOSE

Eligibility criteria:
Inclusion Criteria: a diagnosis of vasovagal syncope as the cause of loss of consciousness,
        >1 lifetime syncope spell preceding enrolment, >-3 points on the S3 score for structurally
        normal hearts, >18 yrs of age with informed consent -

        Exclusion Criteria: subjects with a negative Physical Activity Readiness Questionnaire
        (PARQ), those who are unable to provide informed consent, those with a VO2max >55ml/kg/min,
        those who exercise more than 30 minutes per day, 3 times per week, other causes of syncope,
        individuals with valvular, coronary, myocardial, or conductive abnormality, significant
        arrhythmia, hypertrophic cardiomyopathy, permanent pacemaker, seizure disorder, heart
        failure, major chronic cardiovascular disease, or renal dysfunction.

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Amnion Bilayer and Stem Cell Combination Therapy on Thin Endometrium Infertile Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients with thin endometrium without scar

          -  Patients with acute thin endometrium post-therapy (medicamentosa)

          -  Patients who are willing to participate in the study

        Exclusion Criteria:

          -  Patients with thin endometrium due to TB

          -  Patients with cancer in the reproductive system
Female
No healthy subjects accepted to join the trial.

Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Comparison of Ultrasound and Videofluoroscopic Imaging Techniques in Diagnosing Dysphagia in Stroke Patients

Eligibility criteria:
Inclusion Criteria:

          -  The Stroke Center inpatients and outpatients with known or suspected dysphagia can be
             included for study as well as patients who are admitted specifically for this
             protocol. (Difficulty swallowing food or pills,changed swallowing ability,coughing or
             choking when eating, shortness of breath during swallowing, food backing up into the
             mouth or nasal passage, fever or voice changes after swallowing, pain when swallowing,
             unexplained loss of weight.

        Exclusion Criteria:

          -  Patients who are severely demented or severely compromised will be excluded if they do
             not have sufficient cognitive ability to follow directions. Non-ambulatory patients
             will be excluded if they cannot be braced or supported within the fluoroscopy unit.
             Highly agitated individuals will also be excluded if they are unable to remain
             confined in the equipment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Tympanostomy Tubes Versus Eustachian Tube Dilation

Eligibility criteria:
Inclusion Criteria:

        Determined to have chronic Eustachian tube dysfunction of at least 3 month duration based
        on a score of ≥ 14.5 on the Eustachian tube dysfunction questionnaire-7 (ETDQ-7),
        regardless of tympanogram status

        Exclusion Criteria:

          -  Insurance that does reimburse for ET balloon dilation

          -  Patients with acute upper respiratory infection

          -  Tympanic membrane perforation

          -  Known middle ear disease such as cholesteatoma, acute otitits media, history of head
             and neck radiation, history of cleft palate, cystic fibrosis, ciliary dyskinesia,
             nasopharyngeal mass and patulous eustachian tube
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: sCAVA - Sleep Assessment Using the CAVA Device

Eligibility criteria:
Inclusion criteria

          -  ≥ 18 years of age

          -  Conversational English and capacity to consent

          -  Availability to take part in the study

        Exclusion criteria

          -  Potential participants who have a diagnosed sleep disorder, ongoing neurological or
             psychiatric disorders, or any potentially life-threatening conditions.

          -  Potential participants who have a history of dermatological disease, fragile skin, or
             damage around the forehead.

          -  Potential participants who have an allergy to plasters and/or medical adhesives
             (similarly to materials used in the device).

          -  Pregnant or nursing mothers.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: DMPA & High Dose Oral Progestin (MPA) Tablets in Outpatient Treatment of Acute Excessive Vaginal Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Age 18- 50

          -  Non-pregnant

          -  Candidate for outpatient management

          -  Able to understand and follow instructions

          -  Vital signs stable

          -  No severe anemia

          -  No medical conditions requiring transfusion

        Exclusion Criteria:

          -  Pregnancy

          -  Breast cancer current or in last 5 years

          -  Allergy to MPA or DMPA

          -  Previous hormonal therapies

          -  Unstable vital signs

          -  Bleeding excessive enough to require surgical therapy or hospital admission

          -  Desire for pregnancy in next 6 months
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effects of Glucosamine on Joint Fluid in Osteoarthritis Patients

Eligibility criteria:
Inclusion Criteria:

          -  are between 30 and 85 years of age

          -  are clinically diagnosed with moderate to severe knee OA

          -  are recommended for synovial fluid aspiration

        Exclusion Criteria:

          -  are clinically diagnosed with inflammatory arthritis

          -  had previous joint surgery in the study knee

          -  had injection in the study knee within the past 12 months

          -  have taken glucosamine and/or chondroitin supplements within the past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Laparoscopic Total Gastrectomy With Versus Without Bursectomy

Eligibility criteria:
Inclusion Criteria:

          -  Primary gastric adenocarcinoma diagnosed pathologically by endoscopic biopsy

          -  Tumor located in the posterior wall of upper and middle third stomach estimated by
             endoscopy and CT scan

          -  Informed consent

          -  Eastern Cooperative Oncology Group (ECOG): 0 ot 1

          -  American Society of Anesthesiologists （ASA） score: Ⅰto Ⅲ

        Exclusion Criteria:

          -  Pregnancy or female in suckling period

          -  Contraindication to general anesthesia (severe cardiac and/or pulmonary disease)

          -  Severe mental disease

          -  Emergency operation due to complication (bleeding, perforation or obstruction) caused
             by primary tumor
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment