Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Pain Expectations in Subjects With Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Osteoarthritis of the knee or hip

          -  Adult (ages 18-80)

          -  Moderate pain (verbal score of ≥ 4 ≤ 7 on 0-10 scale for average pain intensity with
             normal activity)

          -  American Society of Anesthesiologists physical status 1-3

          -  Healthy subjects without pain

        Exclusion Criteria:

          -  Pregnancy;

          -  Currently taking gabapentin

          -  Currently taking a narcotic prescription medication that is > 50 mg morphine
             equivalents/day

          -  Advanced or unstable cardiac, pulmonary, renal or hepatic dysfunction

          -  History of previous eye surgery

          -  Psychotic disorder or a recent psychiatric hospitalization
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Point-of-Care Ultrasound in the Emergency Department Evaluation of Syncope

Eligibility criteria:
Inclusion Criteria:

          -  18 years and older presenting to the ED with acute syncope (defined as transient loss
             of consciousness) or near syncope (sensation of impending but not actual loss of
             consciousness) as a reason for ED visit.

        Exclusion Criteria:

          -  persistent altered mental status

          -  alcohol or illicit drug-related loss of consciousness

          -  definite seizure, and transient loss of consciousness caused by head trauma.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Optical Coherence Tomography Comparative Study

Eligibility criteria:
INCLUSION CRITERIA:

          1. Patient must understand and sign the informed consent.

          2. Patient must be at least 18 years of age.

          3. Pupillary dilation to at least 6 mm must be possible.

          4. Ocular media must be sufficiently clear to allow for quality images.

        EXCLUSION CRITERIA:

        1. Any condition such as corneal opacifiation that precludes adequate slit lamp examination
        and photography of the fundus.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of knee or hip osteoarthritis with history of pain at the reference
             joint for at least 3 months or clinical diagnosis of low back pain of benign origin
             for at least 3 months

          -  Must be dissatisfied with their current analgesic therapy (e.g. Non-steroidal
             anti-inflammatory drugs NSAIDS, COX-2 inhibitors, opioids, paracetamol/acetaminophen

          -  Have a pain intensity >4 on Numerical Rating Scale

        Exclusion Criteria:

          -  Life-long history of seizure disorder or epilepsy

          -  Any of the following within one year: mild/moderate traumatic brain injury, stroke,
             transient ischemic attack, and brain neoplasm

          -  Severe traumatic brain injury within 15 years (consisting of more than one of the
             following: brain contusion (injuries resulting in hemorrhage), intracranial hematoma,
             unconsciousness or post traumatic amnesia lasting for more than 24 hours) or residual
             sequelae suggesting transient changes in consciousness

          -  History of malignancy within past 2 years, with exception of a successfully treated
             basal cell carcinoma

          -  Presence of significant pain associated with conditions other than osteoarthritis or
             low back pain that could confound the assessment or self-evaluation of pain
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: RCT Novasure Versus Novasure + Mirena IUS in the Treatment of Menorrhagia

Eligibility criteria:
Inclusion Criteria:

          -  Anybody suitable for novasure ablation

        Exclusion Criteria:

          -  Mirena IUS is indicated as treatment
Female
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: The KEN SHE Study on HPV-vaccine Efficacy

Eligibility criteria:
Inclusion Criteria:

          -  Born female

          -  Age 15 to 20 years

          -  HIV-negative

          -  No history of HPV vaccination

          -  Sexually active: history of 1-5 lifetime partners

          -  Resident within study area without plans to move away in the next 37 months

        Exclusion Criteria:

          -  Allergies to vaccine components or latex,

          -  Pregnancy

          -  Hysterectomy

          -  Autoimmune, degenerative, and genetic diseases

          -  Investigator discretion
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study of Pain Catastrophizing

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic knee OA

        Exclusion Criteria:

          -  Younger than 45 years of age or older than 85 years of age

          -  Prosthetic knee replacement or other clinically significant surgery to the arthritic
             knee

          -  uncontrolled hypertension (>150/95)

          -  Heart disease including heart failure

          -  Peripheral neuropathy in which pain testing was contraindicated

          -  Systemic rheumatic disorders including rheumatoid arthritis, systemic lupus
             erythematosus, gout, and fibromyalgia

          -  Neurological diseases such as Parkinson's, multiple sclerosis, stroke with loss of
             sensory or motor function, or uncontrolled seizures

          -  Significantly greater pain in body sites other than in the knee

          -  Daily opioid use

          -  Hospitalization within the preceding year for psychiatric illness

          -  Currently pregnant or nursing/breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Study to Evaluate the Safest Dose Range for FEIBA in Hemophilia A Patients With Inhibitors on Emicizumab

Eligibility criteria:
Inclusion Criteria:

          1. Male patients with congenital hemophilia A of any severity and any age.

          2. History of high titer factor VIII inhibitor (Bethesda unit >5)

          3. Currently prescribed bypassing agent therapy for bleed management.

          4. Current treatment with emicizumab for a minimum of 2 months without interruption.

        Exclusion Criteria:

          1. Active bleed requiring factor therapy at screening.

          2. Treatment with rFVIIa or aPCC 7 days prior to screening.

          3. Surgical procedure 14 days prior to screening.

          4. Current use of any medication other than emicizumab that could affect the coagulation
             system e.g. aspirin, anticoagulants, etc.
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Patient Education Manual on Patients With Knee Osteoarthritis.

Eligibility criteria:
Inclusion Criteria

          -  Idiopathic knee OA-I, II, &III

        Exclusion Criteria:

          -  Post Traumatic OA Knees

          -  Ligament instability

          -  Condromalacia patellae

          -  Knee replacements

          -  Cognitive impairment

          -  Rheumatoid arthritis

          -  Meniscus injury
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of Modified Treatment Regimens for Treatment of Heavy Menstrual Bleeding Using the HerOption® System

Eligibility criteria:
Inclusion Criteria:

          -  Pre-menopausal adult women 30 years of age or older who have completed childbearing

          -  Heavy or prolonged menstrual bleeding

          -  Willing and able to complete all follow-up exams as required by protocol

        Exclusion Criteria:

          -  Known or suspected endometrial cancer or pre-malignant change of the endometrium

          -  Untreated cervical dysplasia

          -  Hereditary malformations of the uterine cavity that would prevent insertion and/or
             placement of the cryoprobe

          -  Uterine myomas > or = to 3 cm in diameter

          -  Past history of invasive treatment for abnormal uterine bleeding or uterine myomas

          -  History of classical (not low transverse incision) cesarean section

          -  Active genital or urinary tract infection or acute pelvic inflammatory disease (PID)

          -  Intrauterine device (IUD) in place

          -  Other medical conditions could be exclusionary upon evaluation for study treatment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Pain and Quality of Life After Inguinal Hernia Repair: Laparoscopic Versus Open Repair.

Eligibility criteria:
Inclusion Criteria:

          -  primary inguinal hernia

          -  unilateral hernia

        Exclusion Criteria:

          -  bilateral hernia

          -  recurrent hernia

          -  incarcerated hernia

          -  large scrotal hernia

          -  known femoral hernia

          -  need for associated procedures

          -  not able to understand the questionaire

          -  immunosuppression (including corticosteroids, radiotherapy, chemotherapy)

          -  chronic renal failure (hemodialysis)

          -  active infection

          -  pregnancy

          -  allergy to polypropylene or cyanoacrylate

          -  patient's refusal and/or absence of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment