Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator

Eligibility criteria:
Inclusion criteria:

          -  Patients with the diagnosis of Osteoarhtritis of the knee, graded according to
             Kellgren as grade 1-4

        Exclusion criteria:

          -  Patients that suffer from acute septic arthritis.

          -  Patients that treated with coumadin and/or other anti-coagulant drugs

          -  Patients that show mental or physical conditions, which preclude compliance with study
             and/or device.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital

Eligibility criteria:
Inclusion Criteria:

          -  all cases of syncope.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.

Subject must be at least 1 Year old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis

Eligibility criteria:
Inclusion Criteria:

          1. Age 18-75 years

          2. Either gender

          3. Patients with chronic liver disease with iron deficiency anemia with transferrin
             saturation<20% and Hemoglobin in Non-pregnant women (15 years of age and above)
             <12g/dl and in men <13g/dl -

        Exclusion Criteria:

          1. Those who do not consent to participate in the study

          2. Inability to obtain informed consent from patient or relatives

          3. Severe preexisting cardiopulmonary disease

          4. Renal dysfunction (S. Creatinine ≥ 2mg/dL)

          5. Pregnancy/Lactation

          6. Post liver transplant patients

          7. HIV infection

          8. Patients who are on psychoactive drugs, like sedatives or antidepressants

          9. Patients who are too sick to carry out the protocol
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Syncope Decision Aid for Emergency Care

Eligibility criteria:
Inclusion Criteria:

          -  Emergency Department patient

          -  Age 30 years or above

          -  Chief complaint of syncope

          -  Capacity to make medical decisions

          -  Speak and read English

          -  Working phone number and fixed address

        Exclusion Criteria:

          -  Altered Mental Status

          -  Cognitive Impairment

          -  Serious acute diagnosis:

             (e.g. clinically significant cardiac dysrhythmia, structural heart disease,
             gastrointestinal hemorrhage, myocardial infarction, pulmonary embolism, pneumonia,
             arterial dissection, serious infection, ectopic pregnancy, subarachnoid hemorrhage, or
             stroke.)

          -  Hemodynamic instability

          -  Inability to read or speak English

          -  Major communication barrier

          -  Lack of phone number or fixed address

          -  Too high risk as per physician judgment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Clinical Study of in Situ Regeneration of Endometrium

Eligibility criteria:
Inclusion Criteria:

        1.Patients with thin endometrium (4mm≤ EMT <7mm )or scarred endometrium (scarred area≤70%)
        which is nonresponsive to estrogen stimulation 2.Infertile patients with clear fertility
        desires 3.20-42 years old 4.Normal ovarian function or with frozen embryos 5.Willing to
        participate in follow-up

        Exclusion Criteria:

          1. Endometrial thickness <4mm or scarred endometrial area>70%

          2. Uterine cavity out of shape and the cavity depth<6.5mm

          3. Abnormal chromosome karyotype

          4. Uterine diseases including large intramural myomas, severe endometriosis, severe
             adenomyosis, severe congenital uterine malformations, endometrial tuberculosis,
             vaginitis and endometritis

          5. Systemic diseases: hypertension, diabetes, and so on

          6. Contraindications to pregnancy

          7. Contraindications to hormone replacement therapy

          8. Medical history of pelvic tumors or receiving pelvic radiotherapy 9 .Involved in other
             clinical studies

        10. Unable to adhere to the follow-up
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: A Difference-In-Differences Analysis of New Persistent Opioid Use After Surgery

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (18 years and older)

          -  Patients undergoing one of the following procedures: laparoscopic cholecystectomy,
             laparoscopic appendectomy, minor hernia repair (including laparoscopic or open
             inguinal, femoral, umbilical, and epigastric hernia repair), open and laparoscopic
             ventral/incisional hernia repair, laparoscopic colectomy, open colectomy, vaginal
             hysterectomy, laparoscopic hysterectomy, and open abdominal hysterectomy

          -  Patients who underwent surgery between January 1, 2013 and December 31, 2019

        Exclusion Criteria:

          -  Patients who are not opioid-naive at the time of surgery, defined as filling 1 or more
             opioid prescriptions between the 12 months to 31 days prior to surgery

          -  Patients without continuous insurance enrollment for at least 12 months before and at
             least 6 months after the date of surgery

          -  Patients still in the hospital on postoperative day 30

          -  Patients not discharged home after surgery

          -  Patients who underwent another surgery within 6 months of their index operation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Identification and Characterization of the Biomarker in Synovial Fluid for Hyaluronic Acid Therapy in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoarthritis

          -  Accept the intra-articular HA injection therapy

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  GERD patients:

               -  typical symptoms of reflux, such as heartburn and/or regurgitation;

               -  gastro-esophageal reflux assessed by 24-h pH-impedance monitoring or a positive
                  symptom association or;

               -  esophagitis assessed by upper GI endoscopy with careful evaluation of the
                  presence and extent of a hiatal hernia (HH).

          -  GERD/FD overlap:

               -  FD symptoms according to the Rome III criteria. The symptoms of FD include one or
                  more of: bothersome postprandial fullness occurring after normal sized meals,
                  early satiation that prevents finishing a regular meal, epigastric pain, and
                  epigastric burning at least several times per week during the last 6 months.

        Exclusion Criteria:

          -  Healthy volunteers:

               -  history of any upper gastrointestinal (GI) symptoms or GI surgery;

               -  psychological disorders;

               -  any drug history;

               -  use of medication altering GI motility;

               -  pregnant or nursing women.

          -  GERD patients:

               -  psychological disorders;

               -  any drug history;

               -  use of medication affecting GI motility;

               -  pregnant or nursing women;

               -  history of GI surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Marigot Osteoarthritis Nutritional Intervention (MOANi) Trial

Eligibility criteria:
Inclusion Criteria:

        The project will focus on patients with a diagnosis of a mild-moderate KOA (level 1-3
        Kellgren and Lawrence and WOMAC in the lower two quartiles), in the target knee, (Frestedt
        et al., 2008) and a BMI between 20 and 30 kg/m2.

        Exclusion Criteria:

        [1] rheumatoid arthritis [2] gout [3] pseudo gout [4] Paget's disease [5] seizure disorder
        [6] insulin dependent diabetes mellitus [7] uncontrolled hypertension [8] unstable
        cardiovascular disease [9] active hepatic or renal disease [10] active cancer and/or HIV
        infection, involved in other clinical trial or experimental treatments in the past 3
        months; pregnant, lactating, or at risk of becoming pregnant; intramuscular/systemic
        corticosteroid injection within 4 weeks; intra-articular corticosteroid injection within 2
        months; or inter-articular hyaluronic acid injection within 4 months prior to enrollment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Study to Evaluate the Efficacy of Seasonique for the Treatment of Cyclic Pelvic Pain

Eligibility criteria:
Inclusion Criteria:

          -  Sexually naïve and agree to abstain from sex during the study

          -  Moderate to severe menstrual-related pelvic pain

          -  Regular spontaneous menstrual cycles

        Exclusion Criteria:

          -  Any contraindication to the use of oral contraceptives

          -  Treatment with an oral contraceptive within the previous 3 months

          -  Previous treatment failure with an extended oral contraceptive regimen
Female
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Eligibility (NLI label): Contradiction