Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: A Study in the Use of Home Blood Pressure Monitoring and Telephone Follow-up to Control Blood Pressure

Eligibility criteria:
Inclusion Criteria:

          -  diagnosed with essential hypertension

          -  systolic blood pressure >140 mm Hg (130 if diabetic) OR diastolic blood pressure > 90
             mm Hg (80 if diabetic)on at least 2 clinic visits prior to randomization

          -  BP at time of screening is > than systolic 140 (130 if diabetic) or diastolic 90 (80
             if diabetic)

          -  patient is prescribed at least 1 antihypertensive medication

          -  Patient is fluent in English

          -  Patient is easily accessible by telephone

        Exclusion Criteria:

          -  persons with stage 4 or 5 chronic kidney disease or end stage renal disease on
             dialysis

          -  Patients with a terminal illness

          -  Patients with severe dementia or serious mental illness

          -  Inability to preform self blood pressure monitoring

          -  Patient lacks a functioning home phone or personal cellular phone

          -  Pregnant or planning to get pregnant

          -  Arm circumference exceeds the allowable limit on the largest home BP monitor cuff
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Study for Patients With Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoporosis

          -  No other severe disabling conditions

          -  Should have at least 1 vertebral or non-vertebral prevalent fracture, and bone mineral
             density T-score should be less than -2.5

          -  Ambulatory

          -  Men (aged 40 to 85 years) or postmenopausal women (aged 55 to 85 years)

        Exclusion Criteria:

          -  History of a disease that affects bone metabolism

          -  History of treatment with any drug that may significantly affect bone metabolism

          -  History or presence of liver disease

          -  History or presence of kidney disease

          -  History of excessive alcohol drinking or drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine.

Eligibility criteria:
Inclusion criteria:

          -  Subject must have a Body Mass Index (BMI) from 19-30 kg/m2

          -  Subject does not present with abnormal clinical lab findings

          -  Subject is able to tolerate a nasogastric pH electrode.

        Exclusion criteria:

          -  Subject is Helicobacter-positive on a C13 urea breath test

          -  Subject has a baseline median 24-hour gastric pH>3

          -  For Part B of the study, subjects are CYP 2C19 poor metabolizers.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Menstrual Cycle Phases on Recovery and Cognitive Function

Eligibility criteria:
Inclusion Criteria:

          -  The study included 80 women with ASA I-II,

          -  Aged 18 to 45 years, who were accepted to participate in the study,

          -  were smoking,

          -  did not use oral contraceptives,

          -  had no menstrual irregularity (regular 28 ± 2 days menstrual cycle)

        Exclusion Criteria:

          -  In preop evaluation patients had difficulties in communication,

          -  amenorrhea,

          -  pregnancy,

          -  delirium,

          -  psychological illness,

          -  major depressive disorder,

          -  patients with a history of acute illness (such as in intensive care unit follow-up),

          -  which may affect cognitive function and daily life activities in the last 6 months,

          -  malignancy,

          -  acute renal failure,

          -  substance abuse and patients older than 45 years and male sex will be excluded from
             the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection

Eligibility criteria:
Inclusion Criteria:

        - All emergency department patients with suspected or diagnosed COVID-19.

        Exclusion Criteria:

          -  Negative screening for COVID-19

          -  recent negative COVID-19 test

          -  no indication for isolation in the Emergency Department
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Low Level Laser Therapy (LLLT) for the Treatment of Hand Osteoarthritis.

Eligibility criteria:
**Patients must be able to get care at Nellis Air Force Base (a military installation) in
        order to participate in this study**

        Inclusion Criteria:

          -  Male and Female Active Duty and DoD Beneficiaries aged 18 years or older

          -  Hand pain, aching, or stiffness

        And at least 3 of the 4 following features:

          -  Hard tissue enlargement of 2 or more of 10 selected joints

          -  Hard tissue enlargement of 2 or more distal interphalangeal (DIP) joints

          -  Fewer than 3 swollen metacarpophalangeal (MCP) joints

          -  Deformity of at least 1 of 10 selected joints

        (The 10 selected joints are the first carpometacarpal (CMC), second and third proximal
        interphalangeal (PIP), second and third DIP joints of both hands.)

        Exclusion Criteria:

          -  Known diagnosis of another type of arthritis: rheumatoid, psoriatic, crystalline,
             inflammatory bowel associated arthritis

          -  History of treatment with LLLT in the past 12 weeks Surgery within the past 6 weeks

          -  Hand fracture within the past 6 weeks

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Effect of Alcohol on Tremors

Eligibility criteria:
INCLUSION CRITERIA:

        A total of 20 subjects will be enrolled in the study. 10 normal subjects will be enrolled
        in the study. All will have an 8-12 Hz component of physiologic tremor as determined by
        neurophysiologic studies. Patients will have a prominent 8-12 Hz spike on accelerometry
        recordings that is associated with an EMG spike at the same frequency.

        5 patients with essential palatal tremor and 5 patients with symptomatic palatal tremor
        will be included.

        All participants must be a minimum of 21 years of age.

        EXCLUSION CRITERIA:

        The presence of any medical condition, such as liver disease, history or family history of
        alcoholism, that can reasonably be expected to subject the patient to unwarranted risk or
        compromise the value of the data.

        Any patient with pathologic tremor, such as parkinsonian rest tremor, essential tremor, or
        tremor secondary to medications or structural brain lesions.

        Any clinically significant laboratory abnormalities.

        Lack of effective contraception.

        Patients who are pregnant.

        Inability to understand the nature of the study or its procedures.

        Persons under the age of 21, who are not of legal age to consume alcohol in Maryland.

        Patients taking any psychoactive medications including certain cough or cold medicine
        preparations.

        No one will be excluded or discriminated against based on the grounds of race, creed,
        gender, color, or national origin. Every attempt will be made to include women and
        minorities in the study population.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Strengthening Exercises Versus Proprioception and Balance Exercises in the Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have a diagnosis of knee Osteoarthritis according to the American Society
             of Rheumatology (ACR) criteria,

          -  Between 45 to 75 years of age

          -  Can read and write in Turkish language

        Exclusion Criteria:

          -  Active synovitis

          -  Taking any physical therapy section in the last 6 months

          -  Have a neurological problems that affect walking

          -  Have an arthritis problem in the ankle and hip joint

          -  Have a history of lower extremity surgery

          -  Intraarticular steroid injection in the last 6 months

          -  Use psychoactive drug

          -  Have a severe defect of vision and hearing, speech disorders

          -  Vestibular dysfunction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: To Compare the Octopus 311 and the Humphrey Field Analyzer 700 Series

Eligibility criteria:
Inclusion Criteria:

          -  Prior Visual Field

        Exclusion Criteria:

          -  Scotopic pupil less than 3 mm
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment