Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonié in the Context of the COVID-19 Pandemic

Eligibility criteria:
Inclusion Criteria:

          1. Adult 18 years-old and older.

          2. Person in employment (on fixed-term or permanent contracts) since (at least) March
             17th, 2020, the date of national implementation of containment measures in response to
             the COVID-19 pandemic.

          3. Signed informed consent.

          4. Person affiliated to a French social security regimen in accordance with Article
             1121-11 of the French Public Health Code).

        Exclusion Criteria:

          1. Report of known active SARS-CoV-2 infection within 10 days prior to the date of
             signing the consent. Known active SARS-CoV-2 infection is defined as a positive result
             on a diagnostic RT-PCR test.

          2. Presence of known symptoms suggestive of COVID-19 within 10 days prior to the date of
             signing consent: fever, fatigue, dry cough, shortness of breath, loss of taste and/or
             smell, headache, body aches, aches and pains, conjunctivitis or colds, digestive
             disorders (vomiting, diarrhea).

          3. A person who is unable to follow and comply with research procedures due to
             geographical, social or psychological reasons.

          4. Pregnant or breastfeeding woman.

          5. Person deprived of their liberty, incapable or incapable of giving their consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          1. Able to comprehend and willing to sign an Informed Consent Form (ICF)

          2. Males or females 18 years of age or older

          3. A diagnosis of familial or sporadic ALS (defined as meeting the possible,
             laboratory-supported probable, probable, or definite criteria for a diagnosis of ALS
             according to the World Federation of Neurology El Escorial criteria)

          4. Maximum voluntary grip strength in at least one hand between 10 & 40 pounds (females)
             and 10 & 60 pounds (males)

          5. Able to swallow tablets with water

          6. Currently taking and tolerating a stable dose of 50 mg BID riluzole

          7. Willing and able to reduce daily dose of riluzole to 50mg QD for 5 weeks

          8. Not currently taking or willing and able to remain off theophylline-containing
             medications during study participation

          9. Patient has a caregiver who is capable of observing and reporting patient status

         10. Upright Slow Vital Capacity (SVC) >50% of predicted for age, height, and sex

         11. Able to perform pulmonary function tests

        Exclusion Criteria:

          1. Life expectancy <3 months

          2. Receipt of investigational study drug within 30 days or 5 half-lives of the prior
             agent, whichever is greater, prior to dosing

          3. Any prior treatment with CK-2017357

          4. Any use of non-invasive positive pressure ventilation (NIPPV), such as Continuous
             Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BiPAP)

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Good Rate of Clinical Response to Cholinesterase Inhibitors in Alzheimer's Disease After Three Months of Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Patients fulfilling the National Institute on Aging and the Alzheimer's Association
             diagnostic criteria of probable AD dementia or the NINDS-AIREN (National Institute of
             Neurological Disorders and Stroke and Association Internationale pour la Recherché et
             l'Enseignement en Neurosciences) diagnostic criteria of AD with cerebrovascular
             disease (AD + CVD)

          -  Patients presenting mild or moderate dementia according to the Clinical Dementia
             Rating (CDR), i.e., CDR 1 or 2, respectively

        Exclusion Criteria:

          -  Patients treated with ChEI or memantine before study entry

          -  Patients diagnosed with frontotemporal dementia, dementia with Lewy bodies or vascular
             dementia,

          -  Patients with CDR 3

          -  Illiterate patients

          -  Patients with different comorbidities, with signs of clinical decompensation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 59 Years old.
Subject must be at most 93 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Integrated Treatment Program for Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          -  Active complaint of knee pain

          -  Diagnosis of knee osteoarthritis according to X-ray

          -  Morning stiffness of less than 30 minutes AND/OR crepitus in active movement

          -  Ability to read Hebrew

        Exclusion Criteria:

          -  Previous participation in physiotherapy treatment program

          -  Gout in knee, rheumatoid arthritis, fibromyalgia

          -  Complaints that appear in a knee which was operated in the past

          -  Dementia

          -  Severe limitations in mobility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: The Aim of This Study is to Estimate the Discontinuation Rate of Low-dose Levonorgestrel-releasing Intrauterine System Due to Self-reported Unacceptable Menstrual Bleeding Pattern in Spanish Women Who Are Using it for the First Time How Intrauterine System for Long Acting Contraception

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 18 to 35 years.

          -  Women who have freely chosen a low-dose LNG-IUS for the first time as contraceptive
             method and it has been successfully inserted previously to invite the woman to
             participate in the study.

          -  Women capable of reading and writing.

          -  Women who signed the informed consent form.

          -  Women who are not participating in an investigational program with interventions
             outside of routine clinical practice.

          -  Women without a mental illness and able to make decisions and follow instructions.

          -  Women without contraindications to a low-dose LNG-IUS according to the local marketing
             authorization.

          -  Women without concomitant medications that may lead to changes in the bleeding pattern
             (e.g. antiplatelet and/or anticoagulants).

        Exclusion Criteria:

          -  None
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia)

Eligibility criteria:
Inclusion Criteria:

          -  male or female subjects 18 years or older

          -  documented diagnoses of hypertension and of hypercholesterolemia or current therapy
             for these conditions

          -  uncontrolled hypertension (SBP >140 mmHg or DBP >90 mmHg) or cholesterol levels above
             their threshold based on their global atherosclerotic risk profile (based on ATP III
             assessment)

          -  ability to give written informed consent

        Exclusion Criteria:

          -  ischemic heart disease, atrial fibrillation, chronic kidney disease and significant
             liver disease

          -  currently prescribed 3 or more drugs to control blood pressure

          -  currently prescribed 2 or more drugs to control hypercholesterolemia

          -  participating in other hypertension/hypercholesterolemia studies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Cytokines and Chemokines in Erythema Migrans

Eligibility criteria:
Inclusion Criteria:

          -  erythema migrans in patients > 18 years

        Exclusion Criteria:

          -  pregnancy or lactation

          -  taking antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Gastric Reflux and Sinonasal Symptoms

Eligibility criteria:
Inclusion Criteria:

          -  Patient aged from18-50 years who have been diagnosed to have gastric reflux by
             gastroenterology departement before the start of treatment, and they also have
             sinonasal symptoms.

        Exclusion Criteria:

          -  Pregnant

          -  Significant nasal cavity malformations

          -  Oncological pathology

          -  Other sinonasal diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women (postmenopausal for at least two years)

          -  Men above 50 years

          -  Treatment for at least two years with denosumab

          -  Last denosumab injection less than five months ago

        Exclusion Criteria:

          -  Low-energy vertebral fracture at any time

          -  Low-energy hip fracture within the last 12 months

          -  BMD T-score < -2,5 (lumbar spine, total hip or femoral neck)

          -  Alendronate treatment for more than three years prior to denosumab treatment

          -  Ongoing treatment with glucocorticoids

          -  Metabolic bone disease

          -  Hormone replacement therapy

          -  Cancer

          -  Estimated glomerular filtration rate (eGFR) < 35 mL/min

          -  Allergy to zoledronic acid

          -  Hypocalcaemia

          -  Contraindications for zoledronic acid according to the SPC
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction