Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Evaluation of Furosap in Human Volunteers

Eligibility criteria:
Inclusion Criteria:

          1. Agrees to written as well as audio-visual informed consent.

          2. Ability to understand the risks/benefits of the protocol

          3. Male between 35-65 years of age.

          4. Diagnosed with Symptomatic hypogonadism

        Exclusion Criteria:

          1. Uncooperative Subjects

          2. Impaired hepatic function indicated by SGOT/SGPT >2.5 times the upper limit of normal.

          3. Abnormal liver or kidney function tests (ALT or AST > 2 times the upper limit of
             normal

          4. elevated creatinine, males > 125 µmol/L or 1.4mg/dl, females > 110 µmol/L or1.2mg/dl)

          5. Patients suffering from CAD

          6. History of malignancy

          7. History of hypersensitivity to any of the investigational drugs Receiving any other
             testosterone booster therapy/medication/supplement within the last 2 months

          8. History of coagulopathies

          9. High alcohol intake (>2 standard drinks per day)

         10. History of psychiatric disorder that may impair the ability of subjects to provide
             written informed consent.

         11. Any medical condition, where the investigator feels participation in the study could
             be detrimental to the subjects overall well-being
Male
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn

Eligibility criteria:
Inclusion Criteria:

          1. Experiencing heartburn at least 2 days per week over the past month.

          2. Having heartburn that responds to heartburn medication.

          3. Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
             in the study.

        Exclusion Criteria:

          1. Having history of erosive esophagitis or gastroesophageal reflux disease diagnosed by
             a physician and confirmed by testing (endoscopy).

          2. Be unwilling to take only the study medication, and antacid provided as a rescue
             medication for relief of acute heartburn during the study.

        Other protocol-defined inclusion or exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Sexual Absorption of Vaginal Progesterone

Eligibility criteria:
Inclusion Criteria:

          -  Sexually active 18-40 year old heterosexual couple

          -  Subject willing to take Mircette birth control pills for at least one cycle (one pack)

          -  Willing to have intercourse at the defined times (at least weekly within a 3 week
             interval, and draw blood within 10 hours of intercourse)

          -  IRB signed informed consent

        Exclusion Criteria:

          -  Undiagnosed vaginal bleeding

          -  Contraindication to oral contraceptives

          -  Liver dysfunction or disease

          -  Known sensitivity to Crinone

          -  Known or suspected malignancy of the breast or genital organs

          -  History of or active thrombophlebitis or thromboembolic disorders

          -  Use of condoms during intercourse

          -  Male erectile or ejaculatory dysfunction
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Corticospinal Excitability and Rehab in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Age 19-65

          -  Grade I or II knee Osteoarthritis confirmed by radiographs or other imaging and at
             least one of the following:

               -  Age > 50 years old

               -  Morning stiffness < 30 minutes

               -  Crepitus

          -  Meet at least 3 of 6 diagnostic criteria for osteoarthritis:

               -  Age > 50 years old

               -  Morning stiffness < 30 minutes

               -  Crepitus

               -  Bony tenderness

               -  Bony enlargement

               -  No palpable warmth

        Exclusion Criteria:

          -  BMI > 30

          -  History of traumatic spine or lower extremity injury within the last 6 months

          -  Previous adverse reaction to electrical stimulation (i.e. burns or hypersensitivity)

          -  Cardiac pacemaker

          -  Metal implants in head

          -  Current pregnancy

          -  Neurological disorders

          -  History of seizures

          -  Unable to give consent or understand the procedures of this study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure

Eligibility criteria:
Inclusion Criteria:

        Left ventricular ejection fraction <40% assessed by transthoracic echocardiography or
        cardiac magnetic resonance with at least 3 months.

          -  Serum ferritin < 100µg/L or 100-299µg/L with transferrin saturation < 20%

          -  clinical stability during last 3 months

        Exclusion Criteria:

          -  Use of intracardiac defibrillator or pacemaker.

          -  Severe to moderate valvar heart disease

          -  Clinical instability, acute coronary syndrome and cardiac surgery within 3 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: HYPGENE-Genetics Fitness Obesity & Risk of Hypertension

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels

Eligibility criteria:
Inclusion Criteria:

        All participants who were allocated to the study all had a history of taking tolerable and
        adequate dose of urate lowering therapy including febuxostat 40-80mg daily or allopurinol
        200-300 mg daily for at least 4 weeks and were defined as difficult to treat or refractory
        gout patients. All patients had a negative of rheumatoid factor and antinuclear antibody,
        Hb>100g/L, total leukocyte count≥3.5×109, PLT≥80×109, serum creatinine<133umol/L,
        transaminases<60U/L and fasting urate≥6.0mg/dL.

        Inclusion criteria for the gouty patients were age≥18 years old, BMI(18-30kg/m2). All
        participants enrolled in our study fulfilled American College of Rheumatology criteria for
        primary gout.

        Exclusion Criteria:

        Exclusion criteria included secondary gout (because it is always associated with some
        underlying renal disease), a history of congestive heart failure, serum
        creatinine≥133umol/L (because the patients have underlying risks if NSAID needed) or the
        use of glucocorticoid>15mg daily,colchicine, uricosuric drugs, chemotherapy or
        immunosuppressive therapy in the past three months.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Needlescopic Inversion and Snaring of Hernia in Girls

Eligibility criteria:
Inclusion Criteria:

          -  Bilateral congenital inguinal hernia Unilateral congenital inguinal hernia Hernia
             defect siameter less than 1.5 mm

        Exclusion Criteria:

          -  Recurrent hernia age less than 6 Month Contraindication to laparoscopy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 10 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: IV Iron vs Oral Iron for Treatment of Anemia in Women With Abnormal Uterine Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 18-50.

          -  Heavy menstrual bleeding, defined as self-report of bothersome periods with
             subjectively heavy flow or frequency greater than 7 bleeding days per month.

          -  Anemia with hgb <11.5 g/dL

        Exclusion Criteria:

          -  Suspected/confirmed malignancy

          -  Severe anemia currently requiring transfusion or emergent operative intervention

          -  Allergy or contraindication to either study drug

          -  Known iron overload

          -  Known sickle cell disease
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effects of Primary Sjögren's Syndrome on Female Genitalia and Sexual Functions

Eligibility criteria:
Inclusion Criteria:

        Clinical Diagnosis of pSS healthy females who presented to the gynecology outpatient clinic
        for reasons other than sexual dysfunction -

        Exclusion Criteria:

        Pregnancy hepatic, renal, interstitial lung, gynecological oncological diseases,
        psychiatric disorders communication impairment

        -
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment