Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: ATP in Alzheimer Disease

Eligibility criteria:
Inclusion Criteria:

          -  1. Men and women aged 55-85 years

          -  2. Diagnosis of possible or probable Alzheimer disease according to NIA-AA 2011
             criteria.

          -  3. Global Deterioration Scale Stadium 5-6 / 15-5 Mini-mental State examination

          -  4. The patient is living with a family as a primary caregiver or a caregiver trained
             to accompany adequate and all intervention and follow-up visits. Patient and caregiver
             knowledge of local languages sufficient.

          -  5. The patient and caregiver willing to participate in the study. There is a high
             probability that patient and caregiver to complete the study.

          -  6. The patient has no sensory deficits preventing evaluation.

          -  7. The patient receives a stable Alzheimer Disease conventional medication. No change
             in treatment at least 90 days prior to selection.

          -  8. The patient receives a conventional stable medication for possible comorbidities.
             No change in treatment at least 90 days prior to selection.

          -  9. The subject or his legal representative give prior informed consent that includes
             genetic studies of Apolipoprotein E and rs11870474.

        Exclusion Criteria:

          -  1. Concomitant severe neurological disease Alzheimer Disease.

          -  2. Presence or history of psychiatric disorders with an emphasis on positive
             behavioral disorders associated with Alzheimer Disease (aggressiveness, agitation,
             delusions, hallucinations, anxiety).

          -  3. Current Severe systemic disease that may prevent completion of the study.

          -  4. History STROKE.

          -  5. History of convulsions and use of anticonvulsants.

          -  6. History of myocardial infarction, angina pectoris, cardiac arrhythmias and other
             serious cardiovascular disorders such as congestive heart failure, and valvular
             aneurysms.

          -  7. Background Diabetes mellitus and / or pictures of hypoglycemia.

          -  8. Uncontrolled hypertension (systolic> 160 mmHg and / or Diastolic> 95 mmHg).

          -  9. Systemic hypotension (SBP <86 mmHg) or bradycardia (<50 beats per minute)

          -  10. Bronchial Asthma History or lung diseases that cause bronchospasm or
             bronchoconstriction

          -  11. Kidney failure (patients with medical restrictions or income parenteral intake of
             fluids).

          -  12. Liver failure.

          -  13. Respiratory failure (need supplemental oxygen supply)

          -  14. Blood donation in the last 90 days or anemia (Hb <10g/dL)

          -  15. Use connection (<30 days prior to screening) of antidepressants, sedatives and
             hypnotics.

          -  16. Using Alzheimer Disease experimental drugs in the last 60 days prior to screening.

          -  17. Women who are pregnant or fertile

          -  18. Inadequate venous access to prevent parenteral administration of infusions.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction