Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: The END Perioperative Smoking Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  adults (age >18)

          -  any gender

          -  scheduled to undergo elective surgery at the San Francisco Veterans Affairs Medical
             Center (SFVAMC)

          -  daily smoker, based on self-report of at least 2 cigarettes/day and having smoked in
             the last 7 days

          -  presenting to the anesthesia preoperative (APO) clinic at least 3 days preoperatively

        Exclusion Criteria:

          -  emergency surgery (booked <24 hours preoperatively)

          -  consumers of non-cigarette forms of tobacco only (pipe, smokeless tobacco) or
             marijuana only

          -  already enrolled in a smoking cessation trial

          -  current smoking cessation pharmacotherapy

          -  daily user of e-cigarettes

          -  previous adverse reaction to e-cigarette or transdermal nicotine

          -  poor proficiency of English language¸as indicated by need for an interpreter
             (including family members) at the preadmission visit

          -  lacking capacity for consent (e.g. due to mental illness or dementia), as indicated by
             consent for surgery and other medical procedures being obtained from a substitute
             decision maker

          -  pregnant or breastfeeding

          -  unstable cardiac condition (unstable angina, unstable arrhythmia)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer

Eligibility criteria:
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the esophagus, stomach,
        pancreas, colon, or rectum More than 30% positively immunoreactive to monoclonal antibody
        CC49 in the metastatic or primary lesion OR TAG-72 antigen serum level greater than 15
        Measurable or evaluable unresectable or metastatic disease by CT scan

        PATIENT CHARACTERISTICS: Age: 19 and over Performance status: ECOG 0-2 Life expectancy: At
        least 3 months Hematopoietic: WBC greater than 3,500/mm3 Platelet count greater than
        150,000/mm3 Hemoglobin greater than 10 g/dL Hepatic: Bilirubin less than 2.0 mg/dL ALT and
        AST less than 3 times upper limit of normal (ULN) (5 times ULN if liver metastases present)
        PTT less than 37.0 seconds INR less than 2.0 Renal: Creatinine less than 2.0 mg/dL Other:
        No known allergy to murine immunoglobulin No iodine allergy No concurrent illness that
        would preclude study Not pregnant or nursing Negative pregnancy test Fertile patients must
        use effective contraception Must be ambulatory and able to comply with study schedule

        PRIOR CONCURRENT THERAPY: Biologic therapy: No prior murine immunoglobulin Chemotherapy:
        Prior or concurrent chemotherapy allowed Endocrine therapy: Not specified Radiotherapy:
        Prior radiotherapy allowed Surgery: See Disease Characteristics
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement

Eligibility criteria:
Inclusion Criteria:

          -  Knee-OA detected by x-ray (Kellgren & Lawrence grade 2 or greater)

          -  Considered a candidate for TKR by the orthopedic surgeon.

          -  The participant is > 18 years of age.

          -  The participant can provide relevant and adequate, informed consent.

        Exclusion Criteria:

          -  Bilateral simultaneous TKR

          -  Revision of prior TKR, unicompartmental knee arthroplasty or high tibial osteotomy

          -  Rheumatoid arthritis

          -  Mean VAS > 60mm on a 0-100mm scale

          -  Investigator considers that the mental condition of the participant does not allow
             participation.

          -  The participant must not be pregnant or plan pregnancy during the study.

          -  Inability to comply with the protocol;.

          -  Inadequacy in written and spoken Danish.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Physiotherapy as a Complimentary Treatment in Reducing Viral-Load, Complications, Death, Expedite Discharge and Improve Quality of Life, Exercise Endurance and Capacity in Stroke Survivors With CoViD-19: A Clinical-Controlled Study

Eligibility criteria:
Inclusion Criteria:

          -  Stroke survivors with COVID19

          -  Non-stroke individuals with COVID19

        Exclusion Criteria:

          -  Stroke survivors still in inpatient hospital care
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 120 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea

Eligibility criteria:
Main Inclusion Criteria:

          -  Healthy patients with rosacea

          -  Males and females ≥18 years of age

          -  10 to 40 papules and pustules and ≤2 nodules

          -  Score of 2 to 4 on the IGA

          -  Presence of telangiectasia

          -  Moderate to severe erythema

        Main Exclusion Criteria:

          -  Use of topical acne treatments or topical or systemic antibiotics

          -  Use of systemic retinoids within 90 days of baseline

          -  Use of an investigational drug within 90 days of baseline

          -  Pregnant or nursing women

          -  Women of childbearing potential not using an adequate form of contraception

          -  Change in method of contraception within 4 months of baseline

          -  Known hypersensitivity to tetracyclines

          -  Surgeries that bypass or exclude the duodenum or achlorhydria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  All reducible inguinal hernias will be included in the study

        Exclusion Criteria:

          -  Irreducible hernia after anesthesia

          -  Obstructed and strangulated hernias

          -  Pediatric hernias

          -  Associated other hernias like ventral hernias

          -  Unfit for spinal anesthesia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Artelon Metatarsophalangeal (MTP) Spacer

Eligibility criteria:
Inclusion Criteria:

          -  The patient experiences pain and limitations of the great toe dorsiflexion at the
             MTP-I joint.

          -  The patient has a clinically and radiographically verified arthritis in the MTP-I
             joint indicating the need for surgical treatment.

          -  The patient reads, understands and is able to complete the study questionnaires in
             Swedish.

          -  The patient has received written and oral information regarding the study and has
             signed the informed consent form.

        Exclusion criteria:

          -  The patient has a pronounced hallux rigidus without mobility in the MTP-I joint (ROM =
             0°).

          -  The patient has previously received surgical treatment affecting the anatomy of the
             MTP-I joint.

          -  The patient has a systemic rheumatic disease, ongoing infection, hallux valgus or is
             seriously ill.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Single-center Study on Laparoscopic Distal Subtotal Gastrectomy for Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Age from over 18 to under 75 years Primary gastric adenocarcinoma (papillary, tubular,
             mucinous, signet ring cell, or poorly differentiated) confirmed pathologically by
             endoscopic biopsy cT2-4a, N0-3, M0 at preoperative evaluation according to the AJCC
             Cancer Staging Manual Seventh Edition Expected curative resection through distal
             subtotal gastrectomy with D2 lymphadenectomy Performance status of 0 or 1 on ECOG
             (Eastern Cooperative Oncology Group) scale ASA (American Society of Anesthesiology)
             score class I, II, or III Written informed consent

        Exclusion Criteria:

          -  Women during pregnancy or breast-feeding Severe mental disorder History of previous
             upper abdominal surgery (except laparoscopic cholecystectomy) History of previous
             gastrectomy, endoscopic mucosal resection or endoscopic submucosal dissection Enlarged
             or bulky regional lymph node diameter over 3cm by preoperative imaging History of
             other malignant disease within past five years History of previous neoadjuvant
             chemotherapy or radiotherapy History of unstable angina or myocardial infarction
             within past six months History of cerebrovascular accident within past six months
             History of continuous systematic administration of corticosteroids within one month
             Requirement of simultaneous surgery for other disease Emergency surgery due to
             complication (bleeding, obstruction or perforation) caused by gastric cancer FEV1<50%
             of predicted values
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 74 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Laparoscopic Measuring Device Study

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients with hernia defect that requires laparoscopic measurement

        Exclusion Criteria:

          -  Minors
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: The Use of Cyclokapron for Treatment and Management of Women With Bleeding Disorders

Eligibility criteria:
Inclusion Criteria:

          -  all menstruating women regardless of age

          -  Women with heavy periods as measured by pictorial blood assessment chart

          -  Women diagnosed with a bleeding disorder

        Exclusion Criteria:

          -  Acquired defective color vision

          -  Factor VIII, Factor IX, FactorXI levels >250%

          -  An inherited thrombophilic defect detected because of a positive family or personal
             history of thrombosis

          -  Current use of oral contraceptives
Female
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment