Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic adenomyosis

          -  irregular menstrual bleeding and dysmenorrhea .

        Exclusion Criteria:

          -  asymptomatic patients -

          -  non-lactating patient

          -  not desire for pregnancy

          -  no hormonal treatment more than 6 month even contraception e.g IUD

          -  no focal lesion of uterus (malignancy ,fibroid or adenxal mass )
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes

Eligibility criteria:
Inclusion Criteria: To be in the study, the participant must meet the following criteria

          1. Diagnosis of hereditary aortopathy based upon:

               -  Confirmation of a disease causing mutation in a known aortopathy disorder OR

               -  Confirmation of disease based on published clinical criteria

          2. Participants is male or female and greater than 30 days old

          3. Participants are able to undergo standard of care cardiac monitoring including an
             echocardiogram

          4. Willing and able to provide written informed consent by parent(s) or guardian(s) after
             the nature of the study has been explained and prior to any research related
             procedures

          5. Signed HIPPA compliant research authorization

        Exclusion Criteria: Participant will be excluded from the study for any of the following
        criteria

          1. Diagnosis of a hereditary aortopathy can not be confirmed

          2. Existence of an additional comorbid condition- including a co-existing genetic
             syndrome, heart failure, renal disease, rheumatologic disease, history of malignancy,
             thyroid disease, recent stroke, other life-limiting illness not related to
             cardiovascular disease.

          3. Extreme prematurity, <28 weeks gestational age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream

Eligibility criteria:
Inclusion Criteria:

          -  mature (above 18 years old) patients that suffer tinnitus (unilateral/bilateral) with
             sensorineural hearing loss

        Exclusion Criteria:

          -  patients that are treated for tinnitus( psychological treatment, hearing aid)

          -  drugs that affect the CNS

          -  sensitivity to amide anaesthetic

          -  hepatic failure

          -  usage of antiarrhythmic drugs

          -  severe depression any patients that develops during the trial local/ systemic symptoms
             such as rash, pain, itching, fever, nervousness,palpitations will be omitted from the
             study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Effect of Curcumin on Iron Metabolism in Healthy Volunteer

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index between 18 et 25 Kg/m²

          -  Non smoker

          -  No swallowing disorders

          -  Normal clinical exam

          -  Normal ECG

          -  Normal values for routine biological tests : serum iron, transferrin saturation,,
             hemogram ferritin, C Reactive Protein, AST, ALT, HDL and LDL cholesterol,
             triglycerides

          -  No C282Y mutation within the HFE gene

          -  Affiliation to social security

          -  Written informed consent obtained

        Exclusion Criteria:

          -  Chronic or evolutive disease

          -  Infection during the 7 days before each sequence

          -  Drug or alcohol (>30g) abuse

          -  Current treatment

          -  Known food allergy

          -  stay at altitude (> 1500m) in 2 months

          -  Positive serology for hepatitis B or C virus or HIV.

          -  Transfusion or blood donation during the last three months.

          -  Exclusion period on the healthy volunteer National File.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effectiveness of Cane in Osteoarthritis (OA) Patients

Eligibility criteria:
Inclusion Criteria:

          -  Primary Knee osteoarthritis (ACR criteria)

          -  VAS for knee pain between 3 and 7

          -  No changes the NSAID intake or physical activity in the previous 3 months

        Exclusion Criteria:

          -  Symptomatic heart or pulmonary disease

          -  Severe systemic disease

          -  Other symptomatic disease in the lower limb or in the upper limb that will carry the
             cane

          -  Joint injection in the previous 3 months

          -  PT in the previous 3 months

          -  Previously cane use

          -  Start regular physical activity in the last month
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Effects of Gastrostomy on Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  patients > 18 years-old

          -  ALS certain or probable

          -  vital capacity (respiratory) > 70 %

          -  under riluzole

        Exclusion Criteria:

          -  ALS in family

          -  other conditions affected survival and QoL

          -  cognitive impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Selective Neurectomy and Mesh Removal for Chronic Postherniotomy Pain

Eligibility criteria:
Inclusion Criteria:

          -  Adult ( more than 18 years old) patients with chronic pain after groin hernia surgery,
             and pain related impairment of everyday function. The pain should have occurred after
             previous open surgery.

          -  The patient should be able to locate to a specific area with maximum pain. Patients
             should be able to understand and use pain scales, and the AAS-scale.

        Exclusion Criteria:

          -  All that contradicts the above
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Transversus Abdominis Plane Block and Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

        ASA I-III patients undergoing inguinal hernia repair with a mesh

        age between 18 and 75 years old

        ability to read and write greek

        -

        Exclusion Criteria:

          -  Inability to consent to the study

          -  BMI >40kg/m2

          -  Skin infection at the puncture site

          -  Contraindication to mono-amide local anaesthetics, paracetamol, NSAID's (parecoxib)

          -  Preoperative use of opioids or NSAID's for chronic pain conditions
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: A Comparison of Accelerometers for Measuring Daily Activity in Sarcoid

Eligibility criteria:
Inclusion Criteria:

          1. Male or Female aged over 18

          2. Diagnosed with sarcoidosis by either; biopsy confirming non-caseating granulomas
             consistent with sarcoidosis, or multi-disciplinary interstitial lung disease meeting
             diagnosis of sarcoidosis.

          3. Ambulatory patient (not wheelchair or bed-bound)

          4. Able to provide written informed consent

        Exclusion Criteria:

        1. Unable to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

        Turner's syndrome-compatible karyotype No Y material in peripheral karyotype Bone age no
        greater than 11 years --Prior/Concurrent Therapy-- No more than 12 months of prior
        estrogen, androgen, or growth hormone
Female
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: The Positively Quit Trial for Smoking Cessation

Eligibility criteria:
Inclusion Criteria:

          -  greater than or equal to age 18 (as NRT is not FDA approved for adolescents)

          -  self-report smoking cigarettes

          -  positive cotinine test

          -  motivated to quit

          -  own a smart phone, laptop, desktop, or tablet computer

          -  able to join group from a private space with Internet access

          -  demonstrate the ability to connect to the HIPAA-compliant videoconferencing system,
             Zoom, over the internet h) speak English i) can provide Florida residency
             (state-issued identification or mail with person's name and Florida address) j) living
             with certain health conditions

        Exclusion Criteria:

          -  pregnant, breastfeeding, or have other contraindications to NRT

          -  receiving other tobacco treatment, or

          -  inability to communicate coherently in English during the video-conferencing test or
             other pre-enrollment interactions
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction