Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: HMB- Data Collection Methods

Eligibility criteria:
Inclusion Criteria:

        Patients who are presenting for gynecologic visits or well-woman examinations who still
        have an intact uterus and are between the ages of 18 and 51 years, have abnormal uterine
        bleeding, and can read and write in English.

        Exclusion Criteria:

          -  Women who are presently on a treatment for abnormal uterine bleeding.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 51 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          1. Gender:Male or female.

          2. Age: from 20 y/o to 75 y/o.

          3. The diagnosis is Gastroesophageal Reflux Disease.

          4. With the symptoms of heartburn or acid regurgitation.

          5. After explaining thoroughly the whole research purpose or process, the clients are
             willing to sign the agreement.

        Exclusion Criteria:

          1. Exclude peptic ulcer, gall bladder stone (including intraheptaic and common hepatical
             duct) and major diseased of cancer.

          2. Barrett's esophagus or esophagus stricture.

          3. The operation history of esophagus or gastroduodenoal regions.

          4. Tarry stool suspected GI tract bleeding.

          5. With the history of alcohol or drug abuse.

          6. The clients with the history of study drug allergy.

          7. The clients with psychologic cannot cooperate with each other.

          8. The pregnant woman or the lactating women.

          9. Abnormal liver function such as GOT, GPT elevated over double the normal range.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Study on Ultrapro vs Polypropylene: Early Results From a Multicentric Experience in Surgery for Hernia

Eligibility criteria:
Inclusion Criteria:

          -  Elective surgery

          -  Males and females

          -  Adults over 18

          -  All primitive inguinal hernia

        Exclusion Criteria:

          -  Emergency surgery

          -  Impossibility to complete the follow-up

          -  Patients with acquired immunodeficiency symptoms

          -  Patients with relapsed inguinal hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Assessment of Iron Deposition in Major Organs of Hemodialysis Patients

Eligibility criteria:
Inclusion Criteria:

          -  patients for study are > 50 years of age,

          -  on chronic hemodialysis for at least one year,

          -  with serum ferritin levels > 2000 ng/ml and TSAT > 30%.

        Exclusion Criteria:

          -  malignancies,

          -  any active infection requiring systemic antibiotic therapy, and

          -  hospitalization within the two weeks before screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Continuous Measurement of the Activity for Clinical Evaluation at Home, for Non-ambulant Neuromuscular Patients

Eligibility criteria:
Inclusion Criteria:

          -  age over 10 years

          -  neuromuscular disease documented by genetic testing or by muscle biopsy

          -  not able to walk 10 meters without support

          -  capable of sitting upright in a wheelchair for at least 3 hours

          -  subject affiliated to a social security system

          -  subject who signed an informed consent

        Exclusion Criteria:

          -  severe intellectual impairment limiting the comprehension of the demanded tasks

          -  acute neurologic, inflammatory, infectious, endocrine, orthopedic disease in the month
             preceding the inclusion

          -  surgery scheduled within 3 weeks after enrollment

          -  surgery at upper limbs in the three months preceding the inclusion

          -  pregnant or nursing women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Comparation of Endoscopic Biopsy and Postoperative Specimen for the Molecular Diagnosis of Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Lower age limit of research subjects 18 years old and upper age limit of 75 years old.

          2. Histologically proven primary gastric adenocarcinoma (Diagnostic biopsies must be
             collected within 12 months prior to enrollment).

          3. Written informed consent from the patient.

          4. Patients planned for radical R0 gastrectomy.

        Exclusion Criteria:

          1. Female in pregnancy or lactation.

          2. Patients with gastric cancer who can not undergo tumor resection

          3. Suffering from other serious diseases, including cardiovascular, respiratory, kidney,
             or liver disease, complicated by poorly controlled hypertension, diabetes, mental
             disorders or diseases.

          4. Patients with poor compliance or considered to be poor compliance.

          5. Patients received any anticancer drugs, biotherapy, radiotherapy or immunotherapy
             within 4 weeks before or after enrollment.

          6. Patients after organ transplantation, long-term need to take immunosuppressants,
             autoimmune diseases.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with ET by a Movement Disorder Neurologist.

          -  Tremors that improve with alcohol.

          -  Ability to abstain from drinking alcohol or caffeine for at least 2 days before both
             the screening and fMRI visits

          -  Over the age of 21.

        Exclusion Criteria:

          -  Significant non-ET related abnormal findings during neurological exam.

          -  Presence of a tremor at rest.

          -  Pregnant or nursing.

          -  Unable to safely undergo MRI based on completion of a safety questionnaire.

          -  History of dementia, brain tumor, stroke, head trauma or a vascular malformation based
             on history or MRI findings.

          -  Severe active medical condition, such as cardiovascular disease, that prevents subject
             from lying flat for up to 120 minutes.

          -  Unable or unwilling to provide informed consent.

          -  Claustrophobia (a fear of tight spaces) or other restrictions that prevent subject
             from undergoing an MRI in a confined space for up to 120 minutes.

          -  Unable to temporarily stop taking medications that may influence liver metabolism or
             brain function.

          -  Tremors so severe that subject cannot safely and effectively undergo MRI

          -  Past/current problems with alcohol abuse or dependence.

          -  Unwillingness to take alcohol (ethanol), which is a potentially intoxicating drug

          -  History of deep brain stimulation or thalamotomy surgery.

          -  Sinus bradycardia, bronchial asthma, or a known allergy to propranolol (Inderal).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Differences in Coagulation Test Kits

Eligibility criteria:
Inclusion Criteria:

        Routine control patients receiving and not receiving oral anticoagulant therapy

        Exclusion Criteria:

        Hemolytic and/or lipemic samples were excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Losartan Versus Atenolol for the Treatment of Marfan Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. Subjects must conform to the diagnostic criteria for MFS;

          2. Subjects must be between 12 and 25 years;

          3. Subjects must have technically suitable echocardiographic windows to obtain the images
             needed to calculate the biophysical properties listed as outcome measures;

          4. Subjects must provide informed consent and/or assent.

        Exclusion Criteria:

          1. Patients with significant aortic or mitral valve regurgitation;

          2. Patients with a medical condition that would preclude them from taking either of the
             study medications or be taken off either medication for a brief period of time;

          3. Female patients who are pregnant, planning to become pregnant, or breast-feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Sperm Parameters and Sexual Quality of Life

Eligibility criteria:
Inclusion Criteria:

          -  Male patient presenting infertility status

        Exclusion Criteria:

          -  none
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment