Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Building a Database of Results From People Without Eye Problems

Eligibility criteria:
Inclusion Criteria:

          -  10 years or older and healthy

          -  No eye diseases

        Exclusion Criteria:

          -  Patients with glaucoma, macular degeneration, diabetic retinopathy, corneal disease,
             eye movement disorders or any eye disease causing vision loss

          -  Patients with visual acuity worse than 20/40

          -  Patients with cataracts or opacities 2+ or greater

          -  Patients with refractive error +6 -6 or greater
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testogel® (Testosterone Gel 50mg/5g) in the Treatment of Male Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Male ages 18-68 years diagnosed as having testosterone deficiency with clinical
             symptoms

          -  A morning (8:00-10:00) serum Total Testosterone concentration of ≤ 300 ng/dL,
             confirmed by a second measurement of morning serum Total Testosterone concentration ≤
             300 ng/dL (samples to be taken 1 - 3 weeks apart)

        Exclusion Criteria:

          -  Abnormal prostate as evidenced by prostatic symptoms, prostatic masses or induration
             on rectal examination, or elevated levels of prostate specific antigen (PSA > 4ng/ml)
             or a maximum urine flow rate of less than 12 ml/sec(of a urine volume greater than
             150ml) (and/or an International Prostate Symptom Score IPSS score >19)

          -  Hematocrit > 50%

          -  Major psychiatric illness

          -  Unable to understand the protocol or to give informed consent

          -  Use of paroxetine and clomipramine

          -  Active alcoholism

          -  History of drug abuse within the past five years;

          -  Use of drugs that might interfere with the results of the study (e.g., antiandrogen,
             estrogens or P 450 enzyme inducers, barbiturates);

          -  BMI < 18 or > 30 according to Chinese BMI references;

          -  Generalized skin disease that may affect absorption of T (e.g., psoriasis) or a known
             skin intolerance to alcohol;

          -  Prolactin > 40 mcg/L;

          -  Untreated severe obstructive sleep apnea;.

          -  Uncontrolled or poorly controlled heart failure
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 68 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Movement Visualization in Pain Management in Patients With Hemophilic Arthropathy.

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A and B

          -  Patients with a medical diagnosis of hemophilic arthropathy and pain

          -  People over 18 years of age

          -  Patients on prophylactic or on-demand treatment regimen with FVIII / FIX concentrates

        Exclusion Criteria:

          -  Patients with neurological or cognitive disorders that impede understanding of the
             questionnaires

          -  Pain free patients

          -  Amputees, epileptics or patients with severe vision problems

          -  Patients who are receiving Physiotherapy treatment at the time of the study

          -  Patients who have not signed the informed consent document
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients with medical refractory essential tremor or tremor-dominant Parkinson's
             disease that are not candidates for deep brain stimulation (DBS), either by
             medical/surgical co-morbidities or by choice.

          -  Patients must have an ECOG status of 0, 1, or 2.

          -  Patients must be at least 18 years of age.

          -  All patients must be given written informed consent.

        Exclusion Criteria:

          -  Patients who have had prior radiosurgery or therapeutic brain radiation therapy.

          -  Patients with medical contra-indications to MRI imaging (e.g. pacemaker).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Half-Dose Flu Vaccine Study in Healthy Adults

Eligibility criteria:
Inclusion Criteria:

        Volunteers may be eligible for this trial if they:

          -  Are able to and have given informed consent.

          -  Are able to understand and comply with all study procedures and to complete study
             diary.

          -  Are aged 18 to 49 years.

          -  Are female, and are not pregnant.

          -  Are available for all study visits.

        Exclusion Criteria:

        Volunteers will not be eligible for this trial if they:

          -  Are allergic to eggs or egg products.

          -  Have a current chronic medical condition for which influenza vaccine is normally
             recommended.

          -  Have received experimental vaccines or medications within 30 days of study entry.

          -  Have received parenteral immunoglobulin within 30 days of study entry.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Individuals (and family members) with early onset osteoarthritis according to the
             following definition:

               -  symptomatic OA before 50 years old

               -  no obvious causes of OA (IMC > 30, dysplasia,joint traumas)

               -  at least three OA locations

        Exclusion Criteria:

          -  Individuals younger than 18 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Specially Designed Eating Plates Effects on Food Intake in Normal Weight and Overweight Children

Eligibility criteria:
Inclusion Criteria:

          -  Over weight / obese children

          -  Normal weight children

        Exclusion Criteria:

          -  Organic disease that cause obesity

          -  Underweight children (BMI percentiles < 5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 13 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Study Assessing Clinical Response

Eligibility criteria:
Inclusion Criteria:

          -  All subjects must have a verifiable diagnosis of ALS of 0.5 to 2 years' duration. The
             diagnosis must be supported by the Revised Criteria of the World Federation of
             Neurology. The grades of diagnosis must be clinically definite ALS or clinically
             probable ALS.

          -  All subjects must be over age 18 and below 65.

          -  The ALS is mildly to moderate based on ALS Health State Scale.

          -  Electrophysiological features show CMAP amplitude of motor nerve normal or mild
             declining.

          -  Serum creatine kinase is normal or mild upper, less than 500U/L.

        Exclusion Criteria:

          -  If anyone of the above eligibility requirements is not met

          -  Use of any other investigational agent within 30 days beginning the treatment phase of
             this study

          -  Severe cardiac, pulmonary, hepatic or/and hematic disease

          -  HIV positivity or signs and symptoms consistent with HIV infection

          -  Pregnant or nursing women

          -  History of cancer with less than 5 years documentation of a disease-free state

          -  History of anaphylactic reaction or hypersensitivity to G-CSF or proteins derived from
             E.coli

          -  Alcohol or drug abuse in recent 1 year

          -  Can't understand or obey the rules of treatment

          -  Blood donor in recent 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Mobile Biosensor for Measuring Vital Signs in Healthcare and Home Settings

Eligibility criteria:
Inclusion Criteria:

          1. Children (≥ 13 years old) and adult male and female subjects who provide written
             informed consent and assent.

          2. Subjects must be willing to use the mobile device and answer questions regarding their
             experience.

        Exclusion Criteria:

        Individuals with prior or recent injury to one or both of their index fingers that would
        prevent or interfere with the use of Maxim biosensor.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Written consent

          -  Age between 18 and 70

          -  Diagnosed with Cushing's syndrome

        Exclusion Criteria:

          -  Suspected malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Study of the Nervous Control of the Anal Sphincter

Eligibility criteria:
Inclusion Criteria:

          -  healthy volunteers

          -  patients with spinal lesion

          -  patients with cauda equina syndrome

        Exclusion Criteria:

          -  pregnant women

          -  pacemaker or other metallic material implanted

          -  epileptic patients

          -  organic colorectal disease

          -  obese patients

          -  previous neurological surgery
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment