Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Improvement of Aerobic Capacity in Cystic Fibrosis Patients With a One-year Home Training Period

Eligibility criteria:
Inclusion Criteria:

          -  Man or woman with cystic fibrosis whose diagnosis was documented on clinical history
             and a test for detecting genetic or sweat test positive

          -  Patient who signed the informed consent (or parents for patients minors)

          -  Elderly aged 15 and over

          -  Patient affiliated with a social security

          -  Patient against non-cardiac indication of physical

          -  Patient in stable condition on a respirator with a higher FEV to 1000 ml

          -  In the case of insulin-dependent diabetes, it must be balanced

          -  Patient had been informed of the results of the medical examination

          -  Women of childbearing age have achieved a pregnancy test on urine negative.

        Exclusion Criteria:

          -  Diabetic patient unbalanced known cardiac pathology

          -  Patient on transplant list

          -  Patient major protected

          -  Patient under guardianship or trusteeship

          -  Safeguard patient justice
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness

Eligibility criteria:
Inclusion Criteria:

          -  Endometrial thickness < 7 mm under estrogen replacement therapy or repeated
             implantation failure

          -  Age between 18 and 46 years

        Exclusion Criteria:

          -  Age < 18 and > 46 years

          -  Pregnancy

          -  Bleeding diathesis

          -  Previous uterine surgery (miomectomy, cesarean section, etc...)

          -  Platelet count < 105/μL

          -  Hemoglobin < 10 g/dL

          -  Presence of a tumor in the wound bed or metastatic disease

          -  Current diagnosis of cancer

          -  Other concomitant active infections
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 46 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Cetrorelix and Ganirelix Flexible Protocol for (IVF)

Eligibility criteria:
Inclusion criteria :

          -  18-39 hyears old with regular menstrual cycles (25-35 days in length);

          -  Body Mass Index between 18-29 kg\m2

          -  Basal follicle-stimulating hormone levels within normal range (<30 mUI\mL)

          -  Absence of clinically relevant anomalies at transvaginal ultrasound examinatio

        Exclusion Criteria:

          -  Patients affected by grade III or IV endometriosis according to American Society for
             Reproductive Medicine (ASRM)

          -  History of Ovarian Hyperstimulation Stimulation (OHSS)

          -  History of poor response in previous IVF\ICSI cycle: ≤ 3 oocytes retrieved

          -  ≥ 3 prior consecutive IVF\ICSI cycle without a clinical pregnancy.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Teledermatology Versus Usual Care on Delay Before Diagnosis and Treatment of Dermatologic Conditions

Eligibility criteria:
Inclusion Criteria:

          -  Consultation with a general practitioner for any motive during which, the general
             practitioner deems necessary to obtain a dermatologic expertise for a skin lesion (for
             diagnosis or treatment)

        Exclusion Criteria:

          -  Emergency, assessed by the general practitioner (needs care or quick telephonic advice
             in the next 24 hours)

          -  Patients for which diagnosis and/or treatment are known by the general practitioner
             (the GP needs a dermatologic advice for a specific treatment (for example= laser,
             instrumental treatment...))

          -  Patient cannot go the dermatologic consultation by himself (for example: dependant
             patients...)

          -  Cognitive or psychiatric impairment (cannot give informed consent)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Bone Age Assessment in Children Using Ultrasound Compared to Wrist X-ray

Eligibility criteria:
Inclusion Criteria:

          -  Children 3.5-18 years old refered to the endocrine pediatric clinic due to short
             stature or other growth abnormalities

        Exclusion Criteria:

          -  Children with bone disease

          -  Children who within the last year took medications which might change bone metabolism
             or mineralization
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 42 Months old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Tracking IUD Bleeding Experiences: An Evaluation of Bleeding Profiles in New Intrauterine Device Users

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women ages 18-40 years with regular, normal menses (lasting between 3-7 days)
             and who are initiating an IUD

          -  Women who can provide bleeding information for 3 cycles off of any hormonal
             contraception (or non-hormonal IUD) and are willing to track bleeding for 180 days

          -  Women who are between 6 and 12 months postpartum (if they have had normal menses the
             last 3 cycles)

        Exclusion Criteria:

          -  Use of any hormonal contraceptive method in the previous 3 months

          -  Irregular duration of menstrual cycles in the last 3 cycles (<21 or >35 days)

          -  Recent history of menstrual bleeding lasting less than 3 days or greater than 7 days
             based on self report of the last 3 cycles

          -  Contraindication to use of the ParaGard® T380A IUD

          -  Mucopurulent cervicitis at the time of IUD insertion

          -  Unable to speak, read, and write in English

          -  Currently pregnant

          -  Plans for or desire for pregnancy in the next 6 months

          -  Currently breastfeeding

          -  Women who are <6 months postpartum

          -  Participation in any clinical investigation utilizing an investigational drug or
             medical device or requiring invasive gynecologic procedures within the 30 days prior
             to enrollment

          -  Wilson's disease

          -  Known coagulopathy or bleeding disorder
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Genetic Aspects of Neurologic and Psychiatric Disorders

Eligibility criteria:
INCLUSION CRITERIA:

        Individuals with selected psychiatric and neurologic disorders, including childhood onset
        schizophrenia, atypical psychosis, mental retardation, bipolar affective disorder, and
        ADHD.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Primary Fascial Closure With Laparoscopic Ventral Hernia Repair: A Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          1. Patient desires an elective surgical repair,

          2. patient is able to give informed consent,

          3. diagnosis of a midline ventral hernia with a fascial defect width on clinical
             examination or CT scan of 3-10 cm in size,

          4. body mass index <40kg/m2,

          5. candidate for LVHR based upon surgeon assessment.

        Exclusion Criteria:

          1. acute or urgent presentation,

          2. multiple defects defined as defects from two separate incisions,

          3. patient has loss of domain assessed,

          4. patient has a severe co-morbid condition likely to limit survival to <2 years,

          5. contamination noted pre-operative or intra-operative,

          6. patient is pregnant or intends to become pregnant during the study period.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment