Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Drug Use Investigation of Kovaltry in Hemophilia A Patients

Eligibility criteria:
Inclusion Criteria:

          -  Male and female hemophilia A patients.

          -  Patients for whom the decision to treat with Kovaltry was determined prior to
             enrollment in the study.

        Exclusion Criteria:

          -  Patients participating in an investigational program with interventions outside of
             routine clinical practice.

          -  Patients with an additional diagnosis of any bleeding/coagulation disorder other than
             hemophilia A
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Effects of Medications in Patients With Hypogonadism

Eligibility criteria:
Inclusion Criteria: hypogonadotropic hypogonadism

          -  decreased serum testosterone concentration below the normal range (serum T <
             300ng/dL),

          -  FSH and LH levels within or below the normal range,

          -  absence of a pituitary or hypothalamic mass lesions on MRI, presence of gonadotropin
             response to repetitive doses of GnRH,

          -  normal smell test and normal karyotypes

        Exclusion Criteria:

          -  previous androgen treatment,

          -  history of smoking,

          -  presence of bilateral anorchia,

          -  intellectual deficiency,

          -  diabetes mellitus,

          -  arterial hypertension or dyslipoproteinemia,

          -  medication of any kind and drug abuse. Because of possible confounding effects,
             patients with other hormone deficiencies were excluded.

        Participants with iron, vitamin B12 or folate deficiency were also excluded.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Hypovitaminosis D : A Link Between Bone/Mineral and Fat/Fuel Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  Elderly subjects (> or equal to 65 years old)without any disease mentioned in the
             exclusion criteria.

          -  BMI ≥ 25Kg/meters squared

        Exclusion Criteria:

          -  Exclusion criteria include: diabetes, subjects with impaired glucose tolerance on
             medication, presence of a chronic disease or major organ failure such as severe heart
             failure, kidney or liver failure, conditions or intake of medications known to affect
             bone metabolism, rickets or osteomalacia, history of kidney stones, a baseline vitamin
             D level of less than 10 ng/ml and history of fragility fractures or an overall
             fracture risk based on FRAX of >10% .

          -  Subjects with impaired glucose tolerance on no medications will not be excluded.

          -  The classification of individuals as diabetics or having impaired glucose tolerance
             will be based on the American Diabetes Association criteria for diagnosis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Structured Non-operative Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Knee-OA detected by x-ray (Kellgren & Lawrence grade 1 or greater)

          -  KOOS4 of ≤ 75

          -  Considered not to be a candidate for Total Knee Replacement (TKR) by the orthopedic
             surgeon.

          -  The participant is > 18 years of age.

          -  The participant can provide relevant and adequate, informed consent.

        Exclusion Criteria:

          -  Prior TKA ipsilateral

          -  Rheumatoid arthritis

          -  Mean VAS > 60mm the last week on a 0-100mm scale

          -  Possible pregnancy or planning pregnancy;

          -  Inability to comply with the protocol;

          -  Inadequacy in written and spoken Danish.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: EFFECT OF FLOW RESTRICTION ON BONE QUALITY WITHIN A MULTICOMPONENT EXERCISE PROGRAM FOR OLDER WOMEN WITH OSTEOPOROSIS.

Eligibility criteria:
Inclusion Criteria:

          -  A woman between 60 and 75 years of age with a medical diagnosis of osteoporosis by
             means of a femur or lumbar densitometry of less than 2.5 standard deviations (SD) of
             peak bone mass.

          -  No history of previous fracture in the last 10 years.

        Exclusion Criteria:

          -  Secondary osteoporosis.

          -  Having suffered a bone fracture in the last year.

          -  Present primary osteoporosis but who presented juvenile osteoporosis in adolescence or
             youth.

          -  Uncontrolled arterial hypertension.

          -  Severe acute respiratory failure.

          -  Uncontrolled orthostatic hypotension.

          -  Diabetes mellitus with acute decompensation or uncontrolled hypoglycemia.

          -  Endocrine, hematological and other associated rheumatic diseases.

          -  Mental health problems (schizophrenia, dementia, depression, etc.) or not being in
             full mental capacity.

          -  Patients with pharmacological treatments of glucocorticoids, anticoagulants and/or
             diuretics.

          -  Patients with coagulation problems or previous cardiac pathology.

          -  People with a body mass index (BMI) equal to or higher than 30.

          -  Subjects who present a systemic disease or any other pathology in which therapeutic
             exercise could be contraindicated.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A 5-Year Follow-up Study Investigating Factors Associated With Osteoporotic Fracture in Chinese Postmenopausal Women

Eligibility criteria:
Inclusion Criteria:

          1. postmenopausal women (normally over 50 years old and years since menopause over than 1
             year) in Peking.

          2. participants without any fracture in 2007 PK-VF study were included in the prospective
             study investigating the association of bone turnover markers/BMD/25(OH)D with fracture
             incidence.

        Exclusion Criteria: participants with years since menopause less than 1 year.
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 108 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Austrian COVID-19 Registry

Eligibility criteria:
Inclusion Criteria:

          -  Age >=18 years

          -  Positive test for SARS-CoV-2

        Exclusion Criteria:

          -  Due to the non-interventional design of the registry there are no specific exclusion
             criteria.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Definite ALS

        Exclusion Criteria:

          -  Primary Lateral Sclerosis (PLS)

          -  Other forms of motor neuron disorders
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: BAY79-4980 Compared to rFVIII-FS in Previously Treated Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Males aged 12 to 70 years

          -  Subjects with severe hemophilia A (< 1% factor VIII [FVIII]:C)

          -  Subjects with equal or greater than 150 exposure days (EDs) with any FVIII in total

          -  Subjects who have been on-demand treatment with a minimum of 1 relevant bleed per
             month or have been on secondary prophylaxis treatment with not more than a 3x/week
             schedule

          -  Subjects with bleeding events and/or treatments during the last 6 months prior to
             study entry which are documented in the subjects medical records

          -  Subjects with no measurable inhibitor activity

          -  Subjects with no history of FVIII inhibitor antibody formation

          -  Written informed consent by subject and parent / legal representative, if < 18 years

        Exclusion Criteria:

          -  Subjects who are receiving primary prophylaxis

          -  Subjects on prophylaxis with documented requirements of > 75 IU/kg/week

          -  Subjects with any other bleeding disease beside hemophilia A (i.e., von Willebrand
             disease)

          -  Subjects with abnormal renal function

          -  Subjects with elevated hepatic transaminases

          -  Subjects on treatment with immunomodulatory agents within the last 3 months prior to
             study entry or during the study

          -  Subjects with known hypersensitivity to the active substance, mouse or hamster
             protein, liposomes or polyethyleneglycol (PEG)

          -  Subjects who require any pre-medication for FVIII injections
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of Kinesio-taping in Knee Osteoarthritis Patients.

Eligibility criteria:
Inclusion Criteria:

          -  Patients with unilateral and bilateral knee OA

          -  O.A with grade 2-3(Kellgren and Lawrence system for classification of osteoarthritis
             of knee)

          -  Experiencing Pain for more than 1 month

        Exclusion Criteria:

          -  Rheumatic diseases, inflammatory arthritis, septic arthritis

          -  Intra-articular corticosteroid injection during the past month

          -  Patients with fracture

          -  Patients with any carcinoma

          -  if patient having any other systemic illness.

          -  Allergic reaction to KT
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment