Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Ultra-sounded Guided Regional Blockade for Lipoma Excision

Eligibility criteria:
Inclusion Criteria:

          -  Patients between the ages of 18 and 60 years

          -  American Society of Anesthesiologists (ASA) physical status I-III

          -  Superficial subcutaneous lipoma excision surgery (sized from 5 to 7 cm)

          -  Able to provide informed consent

          -  Consent to participates

          -  Single procedure

        Exclusion Criteria:

          -  Unable to consent

          -  Do not consent to participate

          -  Patients with local infections in the skin over lipoma

          -  Patients with history of allergy to local anesthetics

          -  More than one procedure is being performed at the same setting
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: DD Assessment With Diaana #2

Eligibility criteria:
Inclusion Criteria:

          -  Patients presenting to the emergency outpatient unit of Geneva University Hospital

          -  Patients suffering from symptoms localized to the superior or inferior member, the
             back, hand the chest wall.

        Exclusion Criteria:

          -  Strictly dermatologic concerns

          -  Toes and inversion ankle trauma (because the diagnosis of those conditions is
             generally obvious)

          -  Medical condition considered as urgent

          -  Inability to complete de digilatized Diaana form (sight problems, language, inability
             to use a tablet computer)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  long history of GERD symptoms

          -  persistent or recurrent symptoms despite optimal medical treatment

          -  persistent or recurrent complications of GERD

          -  reduced quality of life owing to increasing esophageal exposure to gastric juice

          -  pathological values in the preoperative evaluated functional parameters.

        Exclusion Criteria:

          -  any distinct hiatal hernia detectable by gastroscopy or barium radiography

          -  dysphagia

          -  esophageal strictures

          -  poor physical status (American Society of Anesthesiologists (ASA) scores III and IV)
             and pregnancy.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Safety, Efficacy Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A.

Eligibility criteria:
Inclusion Criteria:

          1. Hemophilia A.

          2. FVIII:C <1%. 3）12 and 65 years old.

        4）Has received FVIII treatment and the treatment exposure days ≥100. 5）Has bleeding
        treatment records of at least 3 months before randomization. 6）FVIII inhibitor assay
        results is negative. 7） Subjects should agree to use an adequate method of contraception
        during the study.

        8）Understood and Signed an informed consent form.

        Exclusion Criteria:

          1. Has a history or family history of blood coagulation factor VIII inhibitor.

          2. Has other coagulation dysfunction diseases in addition to hemophilia A.

          3. HIV positive.

          4. Plan to receive surgery during the trial.

          5. Has used immunomodulator within one weeks before the first dose，and less than 7
             half-life periods.

          6. Known to be allergic to experimental drugs or any excipients.

          7. Severe anemia and need blood transfusion.

          8. Serious liver or kidney damage.

          9. Serious heart disease.

         10. Uncontrollable hypertension.

         11. Has participated in other clinical studies within one month before the first dose.

         12. The researchers believe that it is not suitable for participants.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Spirometric Predicted Values in Bolivia

Eligibility criteria:
Inclusion Criteria:

          -  healthy and non-smokers

        Exclusion Criteria:

          -  unhealthy smokers

          -  subjects unable to understand/sign informed consent unable to understand/perform
             spirometric measurements
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis

Eligibility criteria:
Inclusion Criteria:

        - Postmenopausal women with osteoporosis, defined as low bone mineral density (BMD T-score
        at the total hip or femoral neck of ≤ -2.50)

        Exclusion Criteria:

          -  BMD T-score of ≤ -3.50 at the total hip or femoral neck

          -  History of hip fracture

          -  Any severe or more than 2 moderate vertebral fractures, as assessed by the central
             imaging based on lateral spine x-rays

          -  Use of agents affecting bone metabolism

          -  History of metabolic or bone disease (except osteoporosis)

          -  Vitamin D insufficiency (vitamin D repletion and rescreening is permitted)

          -  Current hyper- or hypocalcemia

          -  Current, uncontrolled hyper- or hypothyroidism

          -  Current, uncontrolled hyper- or hypoparathyroidism
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform

Eligibility criteria:
Inclusion Criteria:

          -  Aged 30 years-old or over;

          -  Both sexes

          -  Affiliated to a social security scheme

        Exclusion Criteria:

          -  severe disease compromising life expectancy at 5 years;

          -  Deprived of their liberty by administrative or judicial decision, or under
             guardianship
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy

Eligibility criteria:
Inclusion Criteria:

          -  Hereditary haemochromatosis patients

        Exclusion Criteria:

          -  Malignancies, severe arrhythmias, congestive heart failure and/or recent angina,
             severe liver disease, epileptic seizures preceding in last 3 months before planned
             treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Desarda and Lichtenstein Techniques in Inguinal Hernia Treatment.

Eligibility criteria:
Inclusion Criteria:

          -  primary inguinal hernia

          -  male adults

          -  signed informed consent

          -  god condition of external oblique aponeurosis (assessed during the operation)

        Exclusion Criteria:

          -  age < 18

          -  recurrent hernia

          -  incarcerated hernia

          -  diagnosed mental disorder

          -  manual reduction of hernia on inpatient

          -  infection at groin area

          -  wound or scar at the groin

          -  no consent
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)

Eligibility criteria:
Inclusion Criteria:

          -  • Patients (between 18 to 60 years of age) with PPI dependent GERD and pathologic
             esophageal acid exposure as documented by percentage time esophageal PH less than 4 of
             more than 4.2% on PH-metry during 24-hrs period while off PPI

               -  Patients who are willing to pay the expenses of the ARMA procedure

        Exclusion Criteria:

          -  • Large Hiatal hernia >3cm

               -  Gr C/D esophagitis

               -  Lower esophageal sphincter (LES) pressure<5 or >15 mm Hg

               -  Paraesophageal hernia

               -  GE flap valve grade IV (Hill's classification)

               -  Barretts esophagus

               -  Esophageal dysmotility

               -  ASA physical status >II

               -  Previous esophageal or gastric surgery

               -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: High-dose Prednisone in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  4 to 10 years of age

          -  Ambulant

          -  Confirmed DMD Diagnosis

          -  Steroid naive

          -  Evidence of muscle weakness by MRC score or clinical functional evaluation

          -  Ability to provide reproducible QMT bicep score

        Exclusion Criteria:

          -  History of significant concomitant illness or significant impairment of renal or
             hepatic function, or other contraindication to steroid therapy

          -  Symptomatic DMD carrier

          -  Positive PPD

          -  Lack of prior exposure to chickenpox or immunization

          -  Use of carnitine, glutamine, Coenzyme Q10, other amino acids or any herbal medications
             within the last 3 months

          -  History of symptomatic cardiomyopathy

          -  Prior attainment of quota for the age group in which the patient belongs
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment