Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Electrophysiological Study of the Effects of Limb Cooling on Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Patients with clinical diagnosis of E.T. for at least a year by a movement disorder
             neurologist

          -  A +2 or worse action or kinetic tremor of one or both upper limbs involving at least
             the forearm and/or hand

          -  Ages 18 to 95 years old

        Exclusion Criteria:

          -  (+) sensory loss in the upper extremities

          -  dermatologic lesions in upper extremities (e.g. skin cancer, eczema, fresh or healing
             wounds, abrasions, acne, pustules, abscesses, or skin rash)

          -  known history of sensitivity to cold (i.e., cold urticaria)

          -  known peripheral vascular disease

          -  Raynaud's phenomenon

          -  scleroderma
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Comparative Pharmacokinetic Study of Two Different Strengths of BAY14-2222

Eligibility criteria:
Inclusion Criteria:

          -  Males, age 18 to 65 years

          -  Subjects with Severe hemophilia A with a documented plasma FVIII level of <1%

          -  >/= 150 ED (exposure days) with FVIII concentrates(s) as supported by medical records

        Exclusion Criteria:

          -  Evidence of current or past inhibitor antibody

          -  History of any congenital or acquired coagulation disorders other than hemophilia A

          -  Platelet count <75,000/mm3

          -  Abnormal renal function (serum creatinine >2 times the upper limit of the normal
             range)

          -  Active liver disease verified by medical history or persistently elevated alanine
             aminotransferase (ALT) or aspartate aminotransferase (AST) >5x the upper limit of
             normal or severe liver disease as evidenced by, but not limited to any of the
             following: International Normalized Ratio (INR) >1.4, hypoalbuminemia, portal vein
             hypertension including presence of otherwise unexplained splenomegaly and history of
             esophageal varices
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: A Phase III Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Dry eye patients with Sjögren's syndrome

          -  Corneal and conjunctival damage

        Exclusion Criteria:

          -  Severe ophthalmic disorder

          -  Punctal plugs or surgery for occlusion of the lacrimal puncta
No condition on gender to be admitted to the trial.

Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A Trial of Chronotherapy of Corticosteroids in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Genetically confirmed dystrophin mutation compatible with DMD phenotype. Specifically,
             gene deletion test positive (missing one or more exons) in the central rod domain
             (exons 25-60) of dystrophin, where reading frame can be predicted as 'out-of-frame' OR
             showing complete absence of dystrophin by muscle biopsy.

          -  Ages between 3 years and < 7 years

          -  Steroid-naïve

          -  Signed informed consent

        Exclusion Criteria:

          -  Treatment with CoenzymeQ10, creatine, amino acid supplements within 3 months of study
             entry

          -  Treatment with cardiac medications: beta-blockers, digoxin, and carvedilol

          -  Existing medical condition or physical disability that would alter subject's motor
             development

          -  Existing medical condition that precludes the use of corticosteroids

          -  Inability to swallow sample tablet in bite of soft food*

          -  Investigator assessment that participant or family will not be compliant with
             treatment or study procedures

          -  Been on investigational DMD medication for the past 6 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 6 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A Retrospective Study in Chinese Good Prognosis Patients Undergoing Assisted Reproductive Technology (ART) Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Infertile women who underwent the first GnRH antagonist IVF/ICSI-ET (Embryo Transfer)
             cycle with an available ART outcome

          -  Used Cetrotide in a fixed or flexible antagonist protocol

          -  Age not more than 35 years old

          -  Baseline serum Follicle-stimulating hormone (FSH) level not more than 10
             milliinternational unit per milliliter (mIU/ml)

          -  Body mass index (BMI) not more than 30 kilogram per meter square (kg/m^2)

          -  Normal uterine cavity

        Exclusion Criteria:

          -  Previously underwent 3 or more IVF/ICSI cycles

          -  The total dose of Gonadotropin used was more than 2500 IU in current cycle

          -  Administration of daily 0.125 milligram (mg) Cetrotide

          -  Received an agonist trigger

          -  Use of clomiphene citrate or letrozole during cycles

          -  Presence of endometriosis Grade 3 to 4, confirmed or suspected

          -  Presence of uni-or-bilateral hydrosalpinx

          -  Known history of recurrent miscarriages
Female
No healthy subjects accepted to join the trial.

Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Finacea 15% and Brimonidine 0.33% Gel in the Treatment of Rosacea - A Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female

          -  18 years of age and older

          -  Female subjects of childbearing potential must have a negative urine pregnancy test at
             Baseline

          -  Female subjects of childbearing potential must practice a reliable method of
             contraception throughout the study

          -  Moderate or severe rosacea with an Investigator Global Assessment (IGA) score of 3 or
             4

          -  Able to understand and comply with the requirements of the study and sign Informed
             Consent/Health Insurance Portability and Accountability Authorization forms

        Exclusion Criteria:

          -  Female subjects who are pregnant, breast feeding or who are of childbearing potential
             and not practicing a reliable method of birthcontrol

          -  History of hypersensitivity or idiosyncratic reaction to any component of the test
             medications

          -  Subjects who have not completed the proper wash-out periods for prohibited medications
             and/or procedures

          -  Medical condition that contraindicates the subject's participation in the study

          -  Alcohol or drug abuse is evident within the past 5 years

          -  History of poor cooperation, non-compliance with medical treatment, unreliability

          -  Participation in an investigational drug study within 30 days of the Baseline visit
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: A Study of the Efficacy and Safety of Ulipristal Acetate Intermittent Treatment for Abnormal Uterine Bleeding Associated With Leiomyomas

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women, 18-50 years, inclusive.

          -  Cyclic abnormal uterine bleeding (heavy or prolonged).

          -  Menstrual blood loss (MBL) of ≥ 80 mL as measured by the alkaline hematin method in
             the first 8 days of menses.

          -  Minimum of one discrete leiomyoma observable by transvaginal ultrasound.

          -  Endometrial biopsy without evidence of malignancy or atypical or non-atypical
             hyperplasia.

        Exclusion Criteria:

          -  History of uterine surgery that would interfere with the study endpoints.

          -  Known coagulation disorder including bleeding disorder or clotting disorder.

          -  History of, or current uterine, cervix, ovarian, or breast cancer.

          -  Alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP),
             or total bilirubin two times or greater than the upper limit of normal range.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response.

Eligibility criteria:
Inclusion Criteria:

          -  Women with poor response to ovarian stimulation. The definition of poor response was
             based on the presence of at least one of the following criteria: Age > 40 years old,
             day 2 FSH >9.5 mIU/ml, AMH < 2ng/ml ,at least one previous COH with less than 3
             oocytes retrieved, at least one cancelled attempt due to poor response, estradiol less
             than 500 pg/ml on the day of HCG.

        Exclusion Criteria:

          -  All other women that do not fulfill the above mentioned criteria
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Electrocoagulation Employment During TAPP Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  age ≥18 years

          -  unilateral inguinal hernia

          -  no previous intraabdominal operations

          -  no history of neurological diseases

        Exclusion Criteria:

          -  recurrent inguinal hernia

          -  bilateral inguinal hernia

          -  history of chronic pain syndrome

          -  preoperative ASA classification IV-V
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices

Eligibility criteria:
Inclusion Criteria:

          -  Health volunteers 18 years and above; equal numbers of males and females to address
             Sex As a Biological Variable (SABV); and in sinus rhythm.

          -  Agree to commit to participate in the current protocol.

          -  Provide written informed consent prior to any study procedures being performed (all
             subjects should be able to understand the informed consent form and any other
             documents that subjects are required to read).

        Exclusion Criteria:

          -  Unable or unwilling to provide informed consent

          -  Any other condition that would increase the risk of participation in the study in the
             opinion of the site Investigator.

          -  A difference of >10 mm Hg in left versus right arm oscillometric systolic BP.

          -  Upper extremity arteriovenous hemodialysis shunt.

          -  Wrist distortion or pain from arthritis.

          -  Prior trauma or surgery at the radial artery monitoring site.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment