Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters

Eligibility criteria:
Inclusion Criteria:

          -  No signs and symptoms of pulmonary diseases, normal ventilatory muscle strength and
             agreement to participate and sign the informed consent form.

        Exclusion Criteria:

          -  Presenting neuromuscular diseases, claustrophobia, ruptured eardrum, history of
             spontaneous pneumothorax and playing wind instruments or being a singer. Sample loss
             will be considered as non-attendance at all training sessions.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 24 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Narcolepsy - New Potential Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Diagnosed with narcolepsy (diagnose code G47.4)

          -  16 - 60 years of age

          -  MSLT has shown hypersomnia (sleeping latency < 8 min) & 1 episode REM

          -  HLA-type associated with increased occurrence of narcolepsy

        Exclusion Criteria:

          -  Reduced cognitive function

          -  Other relevant organ disease (that could affect the study results or put the patient
             at risk)

          -  Ongoing bacterial infection in the nose

          -  Comorbidity that can increase the risk of bleeding

          -  Has received treatment with an implantable stimulator or other implantable product in
             the head and / or in the neck

          -  Known pronounced septal deviation

          -  Known allergy to polyvinylchloride or medicinal liquid paraffin

          -  Women not using adequate contraceptives

          -  Participated in a clinical investigational drug trial within the previous 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults

Eligibility criteria:
Inclusion Criteria:

          -  Patients with clinically diagnosed influenza, body temperature ≥ 38 ºС or other acute
             respiratory viral infection, body temperature ≥ 37 ºС, with no less than 2 symptoms of
             catarrhal and intoxication each:

               -  Intoxication symptoms: Dizziness, headache, chills, fever, sweating, fatigue,
                  myalgia, pain while moving eyes, flushing, pale skin, sleep disturbances,
                  decreased appetite, nausea, vomiting, epistaxis, cyanosis, meningeal signs.

               -  Catarrhal symptoms: Sore throat, rhinorrhea and nasal congestion, difficulty
                  swallowing, hoarseness, stridor, wheezing, rattling dry and wet cough,
                  expectoration.

          -  Laboratory confirmation of viral origin of the disease

          -  Uncomplicated influenza and other acute respiratory viral infections

          -  Interval between onset of symptoms and enrollment to the study not more than 48 hours

          -  Have read, understood and signed an informed consent form

        Exclusion Criteria:

          -  Complicated course of influenza and other acute respiratory viral infections
             (secondary bacterial infection)

          -  Pregnancy and Breastfeeding

          -  Severe decompensated or unstable medical or psychiatric conditions (any diseases or
             conditions that threaten the life of the patient or worsen the patient's prognosis)

          -  Cancer, HIV infection, tuberculosis, including those in history

          -  History of alcohol and drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Suspicion of Sjogren's syndrome based on 2016 American College of Rheumatology (ACR)
             criteria;

          -  Age ≥ 18 years

          -  Being affiliated to health insurance

          -  Willing to participate

        Exclusion Criteria:

          -  Pregnant or breastfeeding women,

          -  Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty
             by a judicial or administrative decision, minors, persons of legal age who are the
             object of a legal protection measure or unable to express their consent)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Improve Osteoarthritis Care

Eligibility criteria:
Inclusion Criteria:

          -  Self-reported hip or knee osteoarthritis

        Exclusion Criteria:

          -  Persons who do not understand the Norwegian language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) regular menstrual
        cycles of 24-35 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥8.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  (1) uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus); (2)
             intrauterine adhesions（moderate - severe）, endometriosis, adenomyosis, untreated
             hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm
             and/or endometrial pressure) (3) history of adverse pregnancy (including spontaneous
             abortion, stillbirth, and fetal malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Safety Study of Mini-dystrophin Gene to Treat Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Known null mutation of the Dystrophin gene

          -  Male age of 5 years or older

          -  If taking corticosteroids, must have dose unchanged for the past 3 months

          -  Serum creatine kinase elevation greater than 10x normal value (established by
             Children's Hospital)

          -  Progressive, symmetrical proximal muscle weakness of arms and legs

        Exclusion Criteria:

          -  Unable to cooperate for muscle strength testing

          -  Joint contractures that prohibit muscle strength testing

          -  Concomitant illness

          -  Individuals predisposed to excessive vagal responses (bradyarrhythmia or hypotension)

          -  Controlled substance abuse
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems

Eligibility criteria:
Inclusion Criteria:

          -  Male, 18 - 65 years of age;

          -  Documented testosterone deficiency;

          -  BMI 18 to 33.

        Exclusion Criteria:

          -  Evidence of prostate cancer and benign prostate hyperplasia;

          -  Taking medications that interfere testosterone metabolism;

          -  History of alcohol or drug substance abuse;

          -  Abnormal ECG;

          -  Allergic to transdermal products;

          -  Skin condition that interfere transdermal system application and assessment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluating the Immune Response for COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Positive COVID-19 RT-PCR to the subject or his/her household.

          -  Over 18 years old

          -  Ability to sign an informed consent

        Exclusion Criteria:

          -  Inability to sign an informed consent

          -  Pregnancy
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Recurrent Inguinal Hernia Treatment - Lichtenstein Versus Laparoscopic Totally Extraperitoneal Preperitoneal Hernioplasty

Eligibility criteria:
Inclusion Criteria:

          -  recurrent inguinal hernia

          -  willing to participate

        Exclusion Criteria:

          -  unwilling to participate

          -  bilateral hernia

          -  preference towards either treatment arm
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Evaluation of the Goldstein SonoBiopsy™ Catheter for Diagnosing Endometrial Pathology

Eligibility criteria:
Inclusion Criteria:

          -  Patient with thickened endometrium

          -  Abnormal uterine bleeding

        Exclusion Criteria:

          -  Pregnant

          -  Active pelvic infection

          -  Pelvic inflammatory disease

          -  Blood clotting disorders

          -  Sexually transmitted disease

          -  Uterine perforation

          -  Recent cesarean section
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction