Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI)

Eligibility criteria:
Inclusion Criteria:

          -  Apparently healthy male volunteers (21 - 45 years old)

          -  C-reactive protein (CRP) < 5 mg/L

        Exclusion Criteria:

          -  Blood donation or significant blood loss (e.g. surgery) within the past 4 months

          -  Regular intake of iron and other nutrient supplements within the past 4 months

          -  Regular intake of medication except oral contraceptives

          -  Acute or recent inflammatory or infectious symptoms

          -  Chronic gastrointestinal disorders or metabolic diseases

          -  Smoking

          -  Coeliac disease or gluten-related disorders

          -  Iron deficiency anemia (Hb < 14 g/dL for males) with serum ferritin concentration < 30
             ng/mL)

          -  Non-iron deficiency anemia (serum ferritin concentration within normal range (30 - 300
             ng/mL for males) but low hemoglobin (< 14 g/dL for males)

          -  Iron overload conditions (serum ferritin concentration > 300 ng/mL for males)

          -  Known hereditary disorders of iron metabolism
Male
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients

Eligibility criteria:
Inclusion Criteria:

          -  Consecutive patients diagnosed with definite, probable, or probable laboratory
             supported ALS

          -  Disease duration from first symptoms between 6-24 months to exclude slow and fast
             progression

          -  ALSFRS-R ≥ 30

          -  FVC (%predicted) ≥ 70%

        Exclusion Criteria:

          -  Other medical conditions, like cardiac insufficiency and lung disorders or others
             conditions limiting exercise training;

          -  Heavy smoking habits with laboratorial evidence of significant bronchial constriction;

          -  Signs of associated dementia or psychiatric disorders.

        Note: None of the patients were on tube feeding, invasive or non-invasive mechanical
        ventilation at admission of study protocol (T1).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Study Protocol for CTS and Keyboard Controlled Randomized Trial

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of carpal tunnel syndrome

          -  Completion of a nerve conduction velocity study (NCVS) within the past twelve months
             or a physician waiver of the NCVS

          -  Able to type using all fingers on the keyboard

        Exclusion Criteria:

          -  Do not use all of their fingers when typing

          -  No active symptoms of carpal tunnel syndrome

          -  Unable to type, or flex and extend the fingers, for whatever reason

          -  Unable or unwilling to provide informed consent

          -  Use of pain relievers or medications during study sessions (potentially masking
             symptoms of median nerve entrapment)

          -  Unable to complete the typing activities before their symptoms (swelling associated
             with body ailments or metabolism) changed

          -  Had inconsistent subjective and objective evaluations in the preactivity test

          -  Threaten or abuse the investigator

          -  Unable to perform the activity so as to meet the minimal use requirements

          -  Had such injury as they had no sensation in their hands (i.e. Late stage)

          -  May suffer further injury (as indicated by their medical history) by attempting the
             typing activity

          -  Had non CTS related metabolic problems and upper extremity neurologic conditions,
             current or past, which have similar symptoms to median nerve entrapment, but which
             were not due to median nerve entrapment in the carpal canal
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Effectiveness of Microcurrent for Treatment of Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  symptoms of tennis elbow for at least 3 months

          -  clinical diagnosis of tennis elbow

        Exclusion Criteria:

          -  significant symptom improvement in previous month

          -  receipt of any active treatment for the condition in the previous month

          -  currently under the care of another health professional for tennis elbow

          -  current cervical radiculopathy

          -  other pathology affecting distal upper limb
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: BRAVO Study for Functional Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with functional dyspepsia that fulfill Rome III criteria with inadequate
             relief of dyspeptic symptoms

          -  Age >18

          -  Provision of written consent

        Exclusion Criteria:

          -  Presence of organic pathology identified by upper endoscopy or other investigations

          -  Presence of sliding hiatus hernia as defined by flap valve grade IV disruption of
             morphology at gastro-esophageal junction

          -  Concurrent medications that affect gastrointestinal motility

          -  Presence of acid reflux or heartburn symptoms of more than twice a month

          -  History of gastric surgery

          -  H. pylori infection

          -  Use of PPI or NSAID in the past 4 weeks

          -  Pregnancy

          -  Known hypersensitivity to PPI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Tomographic Findings in COVID-19 and Influenza H1N1

Eligibility criteria:
Inclusion Criteria:

          -  Patients with signed informed consent.

          -  Patients with a positive PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency
             department admission.

          -  Patients with lung CT within 24hrs of specimen collection for PCR test.

          -  Patients with complete 30-day follow-up information.

        Exclusion Criteria:

          -  Patients who are unwilling to undergo a lung CT.

          -  Negative PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency department
             admission.

          -  Patients with a tumor or tumor metastasis on the pulmonary CT.

          -  Patients with a previous or de novo autoimmune disease diagnosis.

          -  Patients with a previous or de novo interstitial lung disease.

          -  Pregnancy.

        Elimination Criteria:

          -  Patients with loss of information on the variables of interest.

          -  Patients without 30-day follow-up information.

          -  Patients who chose to withdraw their participation at any time of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting

Eligibility criteria:
Inclusion Criteria:

          -  adult patients (≥18 years of age) who are undergoing esophago-gastro duodenoscopy
             (EGD) for any reason and are consenting to be enrolled in the study during the study
             period.

        Exclusion Criteria:

          -  the patients who cannot speak English in Canada, who cannot speak Japanese in Japan,
             and cannot speak Persian in Iran.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Inspiratory Muscle Training in Individuals With Cystic Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of cystic fibrosis, confirmed by the sweat test;

          -  14 - 25 years;

          -  Clinical stability;

          -  Absence of bacterial colonization for 4 weeks;

          -  Both sexes;

        Exclusion Criteria:

          -  Inability to perform the protocol established by the study;

          -  Present any intercurrence during data collection;

          -  Being unable to understand and / or perform procedures.

          -  Colonization during study participation;

          -  Patient hospitalization due to worsening of the clinical picture.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with new or previous mild or moderate Alzheimer's disease diagnosed
             by a doctor according to medically-accepted definitions

          -  Patients living in ordinary households (for example in their own home or in the home
             of a family member or friend, not in nursing homes or other long-term care facilities)

        Exclusion Criteria:

          -  Patients who are currently participating in another clinical trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: The Value of PET-CT in Pleural Effusions

Eligibility criteria:
Inclusion Criteria:

          -  Thoracocentesis

          -  Chest X-ray

          -  CT scanning

          -  PET-CT scanning

        Exclusion Criteria:

          -  Missing data

          -  Lung cancer

          -  Thoracic malignancies
No condition on gender to be admitted to the trial.

Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment