Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Treatment of Adrenal Insufficiency in Children

Eligibility criteria:
Inclusion Criteria:

          1. Male and female children less than 6 years of age.

          2. A diagnosis of adrenal insufficiency as confirmed by an inappropriately low cortisol
             usually with other supporting tests.

          3. Receiving appropriate adrenocortical replacement therapy (hydrocortisone with/without
             fludrocortisone).

          4. Adequately hydrated and nourished.

          5. Ability of parents/carers to understand and give written Informed Consent

        Exclusion Criteria:

          1. Clinically evident acute adrenal insufficiency (adrenal crisis).

          2. Inability of the child to take oral therapy.

          3. Concomitant therapy (other than that required to treat adrenal insufficiency, Vitamin
             D, Fluoride, Thyroxine and growth hormone).

          4. Subjects with clinical signs of acute infection or fever on Day 1.

          5. Any surgical or medical condition which in the opinion of the investigator may place
             the subject at higher risk from his/her participation in the study.

          6. Parents/carers of subjects unwilling to consent to saving and propagation of
             pseudonymised medical data for study reasons.

          7. Subjects who are dependent on the investigator or the sponsor.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 6 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

Eligibility criteria:
Inclusion Criteria:

          -  Undergoing liver biopsy for suspected or known hemochromatosis

          -  Undergoing liver biopsy for living-related liver donation evaluation

        Exclusion Criteria:

          -  Contraindication to MRI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Age 30-60, female

          -  Symptomatic (Dysmenorrhea, Palpable mass, Pelvic pain or discomfort, Urinary symptom,
             Increasing size, Menorrhagia) myomas or adenomyosis

          -  Suspected uterine myoma and/or adenomyosis on transvaginal ultrasonography (USG)

          -  At least a 6-month thorough follow-up record available

          -  Informed consent

        Exclusion Criteria:

          -  Endometrial hyperplasia without myoma or adenomyosis

          -  Body Mass Index more than 30

          -  Huge uterus defined by longitudinal uterine diameter larger than 10cm and
             anteroposterior diameter larger than 8cm in USG
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Atopic Dermatitis

          -  Children over 6 months.

          -  Teens lower than 19 years

        No inclusion / Exclusion Criteria:

          -  Diagnostic presence or clinical signs suggesting acute or chronic skin diseases, as
             well as pertinent to the study, which may affect the outcome of the research.

          -  Being in use of drugs that can affect systemically in the course of the disease, such
             as systemic corticosteroids and immunosuppressants, for at least 30 days.

          -  Allergy or severe adverse reactions attributable to the administration of the
             probiotic.

          -  Non adherence to treatment (ie not present regular use, as prescribed) for at least
             one continuous month.

          -  Lack of attendance by more than 50% of ratings (clinical and/or laboratory) to be held
             during the search.

          -  Patient's request (or responsible's request)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 19 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A New Active Vitamin D, ED-71 for Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Osteoporotic patients who meet any of the following condition:

               1. with at least one fragility fracture,

               2. above 70 year-old with bone mineral density below 70% young adult mean,

               3. with bone mineral density below 60% young adult mean

          -  Women three years or more after menopause or men

        Exclusion Criteria:

          -  Current disorders such as primary hyperparathyroidism, Cushing's syndrome,gonadal
             insufficiency, poorly controlled diabetes mellitus or other causes of secondary
             osteoporosis

          -  A history or suspicion of active urolithiasis at any time

          -  Use of bisphosphonates in the past 12 months

          -  Use of medications known to affect bone in the past 2 months

          -  Abnormal serum calcium, urinary calcium, serum creatinine or liver function tests
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Vaginal Cuff Closure in Robotic Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Women scheduled for robotic assisted laparoscopic hysterectomy

        Exclusion Criteria:

          -  Patients who will not consent.

          -  Hysterectomy due to malignant conditions.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Von Willebrand Factor in Pregnancy (VIP) Study

Eligibility criteria:
Inclusion Criteria:

          -  von Willebrand Disease (VWD) patients defined prepartum as Type 1 per National Heart,
             Lung, and Blood Institute (NHLBI) criterion of von Willebrand Factor (VWF) level less
             than 30 percent, or Type 2, or Type 3

          -  VWF and Factor VIII (FVIII) levels obtained in gestational weeks 34-38 will determine
             enrollment in the non-corrector or corrector group:

          -  Patients with gestational week 34-38 VWF:Ag, VWF:Act (or VWF:RCo), or FVIII:Act less
             than 100 percent will be enrolled in the non-corrector group. In patients with an
             isolated VWF:CB type 2 defect, VWF:CB less than 100 percent can also be determined as
             a non-corrector

          -  Patients with VWF parameter levels greater than or equal to 100 percent self-corrected
             at gestational weeks 34-38 will be enrolled in the corrector group

          -  Written informed consent from the patient prepartum, before gestational week 39

        Exclusion Criteria:

          -  Presence of other concurrent disorder of hemostasis, platelet dysfunction, or collagen
             disorders

          -  Presence of liver disease or renal disease, clinical suspicion or diagnosis of
             preeclampsia or eclampsia, HELLP syndrome, TTP, DIC, or other acquired vasculopathy or
             coagulopathy

          -  Age less than 18 years

          -  Inability of the local laboratory to monitor the VWF laboratory tests needed during
             the course of treatment to determine Wilate dosing adjustments
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: the Effect of Chest Expansion Exercises on Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          1. Age of 18 - 60 years.

          2. patients of both genders.

          3. patients diagnosed as pleural effusion by the physician.

          4. patients with asymmetrical chest expansion.

        Exclusion Criteria:

          1. Orthopedic conditions.

          2. Pleural effusion due to transudate conditions like: liver cirrhosis, …. etc.

          3. Malignant conditions.

          4. Cognitive impairments.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers over the age of eighteen that have been recently dismissed from the
             Emergency Department at Mayo Clinic Hospital, Saint Marys Campus.

          -  We will recruit a convenience sample of 100 patients from the Emergency Department who
             have completed their Emergency Department evaluation and treatment and are being
             discharged to home with non-painful conditions.

        Exclusion Criteria:

          -  We will exclude persons under the age of eighteen

          -  Vulnerable populations (pregnant patients and prisoners)

          -  Those with an allergy to any of the study agents

          -  Those with acute pain

          -  Those using antihypertensive or antiarrhythmic agents

          -  Those with significant cardiopulmonary comorbidities (namely history of arrhythmia,
             coronary artery disease, hypertension, and heart failure)

          -  Those with concomitant use of Monoamine oxidase A (MAO) Inhibitors

          -  Those with a diagnosis of angle closure glaucoma or benign prostatic hyperplasia (BPH)

          -  Those with a history of cerebrovascular disease

          -  As well as those with a history of previous nasal surgery or known nasal anatomic
             abnormalities.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment