Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Validation of the Adenomyosis Calculator

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal (defined by having had menstruation the last six month)

          -  If amenorrhea with levonorgestrel intrauterine device, the woman should be < 45 years
             old

          -  Hysterectomy planned due to a benign condition

          -  Hysterectomy does not require morcellation it is allowed to divide the uterus into 2-3
             pieces, given that the orientation of the specimen is still possible for the
             pathologist)

          -  Written consent is given

          -  Can communicate in Norwegian or English at the Norwegian study sites, and Finnish,
             Swedish or English at the Finnish study site.

        Exclusion Criteria:

          -  Gynecological cancer present at the time of inclusion

          -  Use of gonadotropin-releasing hormone agonist or antagonist within the last 3 months
             prior to the ultrasound evaluation

          -  Prior endometrial ablation or resection

          -  Postmenopausal status or no menstrual bleeding for the last 6 months, or amenorrhea
             with levonorgestrel-intrauterine device and age >45 years.

          -  Need for morcellation of the uterus
Female
No healthy subjects accepted to join the trial.

Subject must be at most 52 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Comparison Study of Three Standard Elbow Wrist Hand Orthoses to Limit Forearm Rotation

Eligibility criteria:
Inclusion Criteria:

          -  No prior wrist or elbow injuries on the dominant side of his/her body

          -  Ability to complete study in one sitting of 90-120 minutes

          -  Between the ages of 18 years and 100 years

          -  Ability to follow directions and speak and read English

        Exclusion Criteria:

          -  Prior wrist or elbow injuries on the dominant side of his/her body

          -  Subjects with known rheumatoid arthritis deformities of the wrist or any prior wrist
             surgeries are excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Understanding Pain Perception in Osteoarthritis

Eligibility criteria:
Inclusion criteria:

        Inclusion Criteria for OA patients:

        Study participant will be recruited from rheumatology outpatient clinics and primary care:

          1. fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             knee osteoarthritis

          2. male or female,

          3. symptomatic knee pain

          4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal
             anti-inflammatory drugs

          5. participants between 35 and 90 who will be undergoing knee replacement surgery or
             arthroscopy for osteoarthritis or knee surgery for fractured tibia/femur/fibula with
             osteoarthritis

        Inclusion criteria for Early OA Patients

        Study participant will be recruited from rheumatology outpatient clinics and primary care:

          1. fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             knee osteoarthritis

          2. male or female,

          3. symptomatic knee pain

          4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal
             anti-inflammatory drugs

          5. Participants between 35 and 90 who have osteoarthritis but will not be undergoing knee
             surgery

        Inclusion criteria for Healthy control subjects

        1. Participants aged between 35 and 90 who do not have knee pain or osteoarthritis as a
        comparator group
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Senofilcon A Lenses in Moderate to Severe Dry Eye Disease

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of moderate to severe dry eye associated with either
             Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal
             limbal cell deficiency

          -  A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia

          -  Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning
             perfect ocular comfort and 1 meaning severe ocular pain)

          -  Ability or the resources to insert and remove the study lenses

          -  An OSDI score greater than 42

          -  A willingness to sign an informed consent

        Exclusion Criteria:

          -  No dry eyes or mild dry eyes

          -  A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes

          -  Dry eye comfort score of greater than 50 on a visual analog scale

          -  Unable to insert or remove the study lenses (or have a family member do so)

          -  Have an OSDI score less than 42

          -  Has been diagnosed with neurotrophic keratopathy in either eye

          -  Unwilling to enroll in the study, and unwilling to provide signed informed consent to
             participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: New Patient Support Program in Type 2 Diabetes

Eligibility criteria:
Criteria Inclusion:

          -  age> 18 years,

          -  patients with type 2 diabetes mellitus diagnosis;

          -  able to express consent to the study.

        Exclusion Criteria:

        - Nobody
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effect of Class IV Laser Therapy and Pilates Exercises on Bone Density and Pain in Primary Osteoporosis: A Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Patients with osteoporosis (T-score values below -2.5)

        Exclusion Criteria:

          -  Patients with a history of tumors, ovariectomy, heart disease, renal failure, disc
             prolapse, or any trauma to the back area
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: A Better Way to Decrease Knee Swelling in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Patients diagnosed with knee OA according to the criteria of the American College of
        Rheumatology (ACR), and were considered as stage 2 and 3 according to Kellgren-Lawrence
        criteria.

        Exclusion Criteria:

        Exclusion criteria were previous knee surgery, malignancy, circulation disorder, and
        conditions preventing exercise or causing muscle weakness, pregnancy, diagnosis of mental
        disorder, scar tissue, or metal implants.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease

Eligibility criteria:
Inclusion Criteria:

          -  IgG4-related disease patients or

          -  Sjogren syndrome patients or

          -  Healthy subjects

        Exclusion Criteria:

          -  Presence of autoimmune or inflammatory associated disease

          -  Age less than 18 years
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish

Eligibility criteria:
Inclusion Criteria:

          -  Known or suspected allergy to fish with either positive specific s-IgE or skin prick
             test to one or more fish species

          -  Either positive specific s-IgE or spin prick test to one or more fish species and
             never eaten fish.

        Exclusion Criteria:

          -  Serious chronic disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Mixed Methods Assessment of Exercises for Knee OA

Eligibility criteria:
Inclusion Criteria:

        Patients must elicit 3 of the 6 symptoms to be included:

          -  forty five years of age and over.

          -  stiffness for less than thirty minutes;

          -  crepitus;

          -  bony tenderness;

          -  bony enlargement;

          -  no palpable joint warmth.

        Exclusion Criteria:

          -  previous lower limb joint injection within three months;

          -  previous hip or knee joint replacement;

          -  any severe cognitive, cardio- respiratory, musculoskeletal or neurological - diagnosis
             that prevents participants from exercising;

          -  insoles or braces;

          -  ligament instability;

          -  participants with a body mass index (BMI) over 40 will be issued with a choice of
             completing in the study or being managed by the National Health Service weight
             management service;

          -  other minor health related issues will be assessed prior to the commencement of the
             study to ensure safe practice.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment