Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effectiveness of Hylan GF-20 on Joint Reaction Forces and Kinematic Patterns During Gait in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  ambulatory, unilateral knee OA of at leas 3 months confirmed by radiography, pain
             requiring NSAIDS for at least 2 months

        Exclusion Criteria:

          -  no trauma to target knee within last 5 years, prior viscosupplementation therapy,
             allergy to avian products, inflammatory disease, joint sepsis,varus/valgus >12
             degrees, clinically apparent tense effusion, oral corticosteroids, intra-articular
             injection in any joint within the last 3 months, venous or lymphatic stasis in the
             leg, claudication or PVD, major surgery, arthroplasty in the target joint,
             arthroplasty in non-target knee within the last 6 months, current malignancy or
             treatment within the last 5 years, except for non-melanoma skin cancer, planned
             surgery during the study period, diabetes requiring insulin, use of an investigational
             device or drug (including glucosamine and chondroitin sulfate) within 90 days before
             entering the study, significant psychiatric or neurological disorder, active alcohol
             abuse or drug abuse within the past year.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 41 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of amyotrophic lateral sclerosis according to revised El Escorial criteria

          -  minimum of 18 years

          -  minimum of 6 months of residency in Rhinelnad-Palatinate

        Exclusion Criteria:

          -  patients below 18 years

          -  ALS patients outside Rhineland-Palatinate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: A Prospective Study of Post-operative Opioid Use in General Surgery Patients

Eligibility criteria:
Inclusion Criteria:

          -  >= 18 years of age

          -  undergoing one of 9 elective outpatient operations: partial mastectomy, partial
             mastectomy and sentinel node biopsy, melanoma wide excision and sentinel node
             excision, thyroidectomy, parathyroidectomy, open inguinal hernia repair, laparoscopic
             inguinal hernia repair, laparoscopic cholecystectomy OR

          -  an inpatient on the general surgery service who took at least one oral narcotic

        Exclusion Criteria:

          -  allergic to all narcotics

          -  chronic opioid use

          -  history of opioid or benzodiazepine abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia

Eligibility criteria:
Inclusion Criteria:

          -  all patients with primary hiatus hernia type II-IV who are deemed suitable for surgery

        Exclusion Criteria:

          -  inability to understand the nature of the purpose of the study and/or to give informed
             consent.

          -  American Society of Anesthesiologists physical status-system (ASA) I-III

          -  Achalasia or another severe esophageal motor disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Patients with Cadherin-1 (CDH1) germline mutation known to be pathogenic or likely
             pathogenic, which may also be classified as "significant" or "likely significant"
             (patients with variants of "uncertain significance " are excluded)

        or

        -Patients with Catenin Alpha 1 (CTNNA1) and partner and localizer of breast cancer 2
        (BRCA2) (PALB2) germline mutations suspected to be, or reported to be, associated with
        hereditary diffuse gastric cancer (HDGC) syndrome.

        or

          -  In the absence of a germline CDH1 mutation, patients must meet clinical criteria for
             genetic testing due to a history suggestive of Hereditary Diffuse Gastric Cancer
             (HDGC) syndrome

          -  Age greater than or equal to 18 years.

          -  Physiologically able to undergo upper endoscopy.

          -  Ability to understand and the willingness to sign a written informed consent document.

          -  Pregnant women are eligible during second trimester of pregnancy if clinically
             indicated for evaluation of cancer.

        EXCLUSION CRITERIA:

          -  Current use of therapeutic anticoagulation medication

          -  Known bleeding disorder or thrombocytopenia.

          -  Unstable angina or recent (within 3 months) myocardial infarction

          -  Any clinical contraindication to general anesthesia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients

Eligibility criteria:
Patients (men and nonpregnant women) with systemic hypertension and patients with
        hypercholesterolema will be included for this study.

        Patient with aspirin allergies and those with a platelet count less than 50,000 will be
        excluded.

        Volunteers cannot be in any kind of medication while participating in this study.

        No history of diabetes, peripheral vascular disease, coagulopathy, or vasculitis.

        Must be capable of rendering informed consent for all procedures.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Histopathological Diagnosis of Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic
             pain, menorrhagia, metrorrhagia

        Exclusion Criteria:

          -  refusal of the patient to get enrolled in the study
Female
Accepts Healthy Volunteers
Subject must be at least 38 Years old.
Subject must be at most 52 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study on Von Willebrand Disease and Hemophilia in Cuenca, Ecuador

Eligibility criteria:
Inclusion Criteria:

          -  Subjects living at urban and rural parishes from Cuenca district.

          -  Subjects referred from professionals of public and private health services, who have
             filled the initial hemorrhage survey.

          -  Must be referred women who sign the informed consent form.

          -  Patients who answer the standardized bleeding score questionnaire (BS).

          -  Patients who answer the quality of life questionnaire (SF-12).

          -  Patients who answer the socio-economic survey.

          -  Patients who accept to provide a venous blood sample for the initial laboratory tests.

        Exclusion Criteria:

          -  Women with organic or hormonal bleeding etiologies.

          -  Patients taking medicines which may affect the coagulation cascade or the number or
             function of platelets.

          -  Those women who otherwise do not comply with the inclusion criteria.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  Males who meet the criteria of obese, hypogonadotropic hypogonadism defined as:

               -  Patients with a Body Mass Index (BMI) ≥ 30 kg/m2

               -  Patients with a morning serum total testosterone level < 300 ng/dL on at least
                  two separate occasions during the Screening and/or Baseline periods.

               -  Patients with inappropriately low gonadotropins at screening given the low
                  testosterone:

          -  Luteinizing hormone (LH) ≤ ULN

          -  Follicle stimulating hormone (FSH) ≤ ULN

          -  Estradiol within or above the normal range (defined as ≥ LLN of the approved assay)

               -  Normal hypothalamic/pituitary function, including:

          -  Prolactin: within the normal range

          -  Thyroid stimulating hormone (TSH): within the normal range

          -  Ferritin: within the normal range

          -  Patients agree to use a barrier method of contraception (e.g., condom), for the
             duration of the study and for at least 3 months following their Study Completion visit
             to prevent BGS649 exposure to their partners.

        Exclusion Criteria:

          -  Patients with hypogonadism, not related to obesity or as a result of other underlying
             issues

          -  Patients with significant major organ class illness (e.g. kidney or liver disease).

          -  Other protocol-defined inclusion/exclusion criteria may apply
Male
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Safety and Efficacy of Carbohydrate Drink Ingested Two Hours Before Upper Endoscopy Under General Anaesthesia

Eligibility criteria:
Inclusion Criteria:

          -  age >= 18 yrs

          -  undergoing upper endoscopy procedure under general anesthesia without emergency

          -  informed written consent

        Exclusion Criteria:

          -  emergency

          -  might impair gastrointestinal motility (intestinal obstruction, stenosis)

          -  diseases of the central and peripheral nervous system or neuromuscular diseases

          -  drug-induced gastric emptying disorders

          -  pregnancy

          -  ionic disorders (hyponatremia<125mmol/l ; hypokalemia<3,5mmol/l

          -  hemodynamic disorders (systolic arterial pressure <100mmHg)

          -  unstable diabetes (glycemia>2,5g/l) ± insulin- dependent diabetes ± diabetic
             gastroparesis

          -  the potential for difficult airway management

          -  understanding of the information

          -  patient with bad prognosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment