Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Exercise and Muscle Stimulation in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  patients with grade I or grade II knee OA (based on the Kellgren-Lawrence
             classification;

          -  which was diagnosed by a medical traumatologist;

          -  radiographic changes that demonstrated a reduced joint space in at least one of the
             compartments of the knee;

          -  subchondral bone sclerosis;

          -  consent to participate in the study

        Exclusion Criteria:

          -  patients who had grade III and grade IV knee OA (based on the Kellgren-Lawrence
             classification);

          -  who were involved in another rehabilitation program outside the center;

          -  who presented with clinical symptoms that would prevent them from participating in the
             exercises;

          -  who had heart disease;

          -  cardiac pacemakers;

          -  periarticular metal implants;

          -  who experienced changes in sensitivity;

          -  who had a previous history of knee injury (meniscus, ligaments, sprains);

          -  who had uncontrolled diabetes;

          -  neurological disorders with cognitive impairments;

          -  rheumatic diseases;

          -  history of knee trauma in the last six months;

          -  prior knee surgery;

          -  three consecutive unexcused absences.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment