Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Trial of Vertebroplasty for Painful Chronic Osteoporotic Vertebral Fractures (Vertos V)

Eligibility criteria:
Inclusion Criteria:

          -  VCF on X-ray of the spine (minimal 15% loss of height)

          -  level of VCF Th5 or lower

          -  back pain ≥ 12 weeks at time of X-ray

          -  ≥ 50 years of age

          -  bone edema on MRI of the fractured vertebral body

          -  focal tenderness on VCF level

          -  decreased bone density T-scores ≤ -1

        Exclusion Criteria:

          -  severe cardio-pulmonary condition

          -  untreatable coagulopathy

          -  systemic or local infection of the spine (osteomyelitis, spondylodiscitis)

          -  suspected alternative underlying disease (malignancy)

          -  radicular and/or cauda compression syndrome

          -  contra-indication for MRI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Comparison of Delta-Shaped and Billroth II After TLDG

Eligibility criteria:
Inclusion Criteria:

          -  carcinoma located in the lower 1/3 of gastric body or antrum of stomach

          -  diagnosed by endoscopy ,endoscopic ultrasonography and abdominal CT scan

          -  diameter of the tumor <3cm

          -  no pyloric obstruction

        Exclusion Criteria:

          -  diameter of the tumor ≥3cm

          -  associated with obstruction, bleeding, emergency surgery or surgical intervention

          -  tumor with extensive metastasis

          -  patient had previously undergone gastrostomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS)

Eligibility criteria:
Inclusion Criteria:

          -  Patient has primary Type II hyperlipidemia or mixed dyslipidemia.

          -  If the patient is currently taking a lipid modifying medication other than Zocor &
             he/she is willing to discontinue this medication

          -  LDL-C levels and/or non HDL-C levels above normal.

          -  Reasonable compliance with a standard cholesterol-lowering diet for a minimum of 4
             weeks prior to screening and for the duration of the study.

        Exclusion Criteria:

          -  Patient has an allergy, hypersensitivity, or intolerance to niacin, statins, or their
             derivatives.

          -  HbA1c ≥ 9% in diabetic patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction

Eligibility criteria:
Inclusion Criteria:

          -  Patients scheduled for dental extraction and treated with edoxaban, apixaban,
             rivaroxaban or dabigatran

          -  Not having taken the direct oral anticoagulant on the day of the extraction

          -  Provision of signed and dated informed consent form

          -  Stated willingness to comply with all study procedures and availability for the
             duration of the study

        Exclusion Criteria:

          -  Subjects with any condition that as judged by the Investigator would place the subject
             at increased risk of harm if he/she participated in the study.

          -  Pregnancy or lactation

          -  Known allergic reaction to tranexamic acid
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: The Incidence and Progression of Myopia: Cohort Study

Eligibility criteria:
Inclusion Criteria:

          -  Volunteer subject, , willing to follow the protocol and able to read, comprehend and
             sign the informed consent form,

          -  Age between 17 and 23 years

        Exclusion Criteria:

          -  Vulnerability of the subject,

          -  Participation in another study which might have an influence on vision or interfere
             with study assessments,

          -  Aphakic or pseudophakic (intraocular lens)

          -  Participants who are wearing ortho-K lenses, or undergone any kind of myopia control
             treatments or undergone refractive surgery.

          -  Any current or evolving pathology manifested in the eye or the appendages which might
             have an influence on vision, or interfere with study assessments (e.g. AMD,
             glaucoma…),

          -  Any previous ocular surgery which might have an influence on vision or interfere with
             study assessments (e.g. iridectomy, refractive surgery…),

          -  Any untreated and/or uncontrolled systemic condition which might have an influence on
             vision, or interfere with study assessments (e.g. uncontrolled diabetes, uncontrolled
             high blood pressure…),

          -  Any medical treatment or medication which might have an influence on vision or
             interfere with study assessments (e.g. antidepressants, drugs with atropinic
             effects…),
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 17 Years old.
Subject must be at most 23 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients?

Eligibility criteria:
Inclusion Criteria:

          -  Age >=18 years

          -  Diagnosis of cirrhosis

          -  Admission to hospital

        Exclusion Criteria:

          -  Age < 18 years

          -  Prior enrollment in study (i.e. readmission)

          -  Prisoner

          -  Pregnancy

          -  Prednisone or Hydrocortisone use in last 24 hours
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 110 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis

Eligibility criteria:
Inclusion Criteria:

          -  Women who are 60 to 90 years of age may be eligible to participate

          -  Bone mineral density (BMD) T-Score at hip or spine must be less than -2.5

        Exclusion Criteria:

          -  BMD T-Score at the hip or the spine of less than -4.0

          -  Patients with any severe or more than two moderate vertebral fractures on spinal x-ray
             at entry
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Misoprostol for Non-Viable Pregnancies

Eligibility criteria:
Inclusion Criteria:

          -  Pregnant patients with nonviable pregnancy document by ultrasound

          -  Gestation at or less than 13 weeks by ultrasound measurements

          -  Clinically stable as determined by provider

          -  Afebrile

          -  Hematocrit > 30

          -  Over 18 years of age

        Exclusion Criteria:

          -  History of allergy to, or intolerance of, misoprostol

          -  Refusal to abstain from intercourse for 72 hours

          -  Significant vaginal bleeding (> 2 pad/hr)

          -  History of inflammatory bowel disease
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  18 years or over male patients;

          -  Absent or incomplete puberty development;

          -  Serum testosterone values below 3.47 nmol/L by low or normal serum LH and FSH
             concentrations.

          -  at least two or more pituitary hormone deficiencies

          -  Brain MRI showed absent and thin pituitary stalk, or pituitary hypoplasia and/or
             ectopic posterior pituitary.

        Exclusion Criteria:

          -  cryptorchidism history

          -  other causes of hypopituitarism or severe systemic disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population

Eligibility criteria:
Inclusion Criteria:

          1. Intellectual disabilities (ID) group:

               -  children with mild to moderate intellectual disabilities.

               -  able to walk independently

               -  can follow simple commands

          2. Typical developed children:

               -  age-matched TD children

        Exclusion Criteria:

          1. fracture or receive orthopedic surgery within six months.

          2. Participate in regular soccer training.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment