Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Treatment of Inherited Factor VII Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent by the patient or next of kin or legally acceptable
             representative to collect data on treatment of a given bleeding episode, surgical
             event or prophylactic regimen as specified in the protocol.

          -  If informed consent is provided by the next of kin or legally acceptable
             representative, consent must also be obtained from the patient as soon as he/she is
             able to do so.Informed consent should preferentially be obtained before initiation of
             treatment or as a minimum before entry of data into the database. 2.Males and females
             0 to 90 years of age. 3. Any patient with a FVII deficiency for whom treatment of
             bleeding episodes, prevention related to surgery and primary/secondary prophylaxis is
             considered necessary by the treating physician can be enrolled.

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin

Eligibility criteria:
Inclusion Criteria:

          -  Molecular diagnosis of DMD

          -  Patients 7 - 10 years of age at time of screening

          -  Ambulant

        Exclusion Criteria:

          -  Previous (3 months or less) or concomitant participation in another therapeutic trial

          -  Use of L-arginine, L-citrulline or metformin within the last 3 months

          -  Known individual hypersensitivity to L-citrulline or metformin

          -  Other chronic disease or clinical relevant limitation of renal, liver, heart function
             according to discretion of the investigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 10 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males

Eligibility criteria:
Inclusion Criteria:

        healthy males

        Exclusion Criteria:

        use of anabolic steroids, use of narcotics,
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Effects of Chronic Ozone Exposure on Lung Function

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects aged 50-80 years.

          -  Lives with a significant other.

          -  Has subjective memory complaints. Verbal verification of this subjective memory
             complaint will be obtained from the significant other.

          -  Has no severe, uncontrolled medical condition.

          -  If receiving treatment for a medical condition, that treatment has been stable for at
             least 2 months before entering the trial and to remain stable throughout the trial.

        Exclusion Criteria

          -  Aged less than 50 years or greater than 80 years.

          -  Lives alone.

          -  Has any medical condition not adequately controlled, or likely to interfere with
             performance of the study procedures.

          -  Medication for a medical condition has been changed in the last 2 months or during the
             trial.

          -  Administration of acetylcholinesterase inhibitors and gingko biloba within 2 months
             prior to entering the study.

          -  Has evidence of depression or anxiety

          -  Meets DSM-IV criteria for Alzheimer's or vascular dementia.

          -  Has participated in an investigational drug trial in the previous 30 days.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort

Eligibility criteria:
Inclusion Criteria:

          -  Danish adult patient with GERD-diagnosis verified by upper endoscopy 1997-2014

        Exclusion Criteria:

          -  Any diagnosis of cancer in the gastrointestinal tract during follow-up

          -  Patients with GERD-diagnosis within previous four years or with concomitant diagnosis
             requiring independent anti-secretory treatment will be excluded (DK25.0-9, DK26.0-9,
             DK27.0-9, DK22.7 & DE16.4B).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy

Eligibility criteria:
Patients of either gender, aged 18-80 years.

        NYHA functional class III/IV, or syncope, or greater than or equal to 2 presyncope despite
        verapamil and/or Beta-blocker therapy.

        LV outflow tract gradient greater than or equal to 30 mm Hg at rest or greater than or
        equal to 50 mm Hg following isoproterenol infusion to a heart rate of greater than 100 bpm.

        No patients with mid-cavity obstructive HCM.

        No patients with LV septal wall thickness less than 15 mm estimated by echocardiography.

        No patients with greater than 50 percent luminal narrowing in a major coronary artery
        vessel.

        No patients with chronic atrial fibrillation.

        No patients with a positive pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol

Eligibility criteria:
Inclusion Criteria:

          -  Adult Taiwanese outpatients with type 2 diabetes mellitus and high cholesterol

          -  Hemoglobin A1c levels of ≤10%, LDL-C levels of ≥130 mg/dL, and serum triglyceride
             levels of <400 mg/dL

        Exclusion Criteria:

          -  Type I diabetes mellitus

          -  Secondary causes of high cholesterol

          -  Elevated liver enzymes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Male ≥18 years of age

          -  Severe hemophilia A (past evidence of circulating FVIII activity of < 1% normal)

          -  Treated or exposed to FVIII concentrates or cryoprecipitate for at least 150 exposure
             days

          -  ≥12 bleeding episodes if receiving on-demand therapy over the preceding 12 months

          -  Agree to use double barrier contraceptive until at least 3 consecutive semen samples
             are negative for AAV 2/6 after SB-525 infusion

        Exclusion Criteria:

          -  Presence of neutralizing antibodies

          -  Current inhibitor, or history of FVIII inhibitor (except for transient low titer
             inhibitor detected in childhood)

          -  History of hypersensitivity response to FVIII

          -  History of Hepatitis B or HIV-1/2 infection

          -  History of Hepatitis C, unless viral assays in two samples, collected at least 6
             months apart, are negative

          -  Evidence of any bleeding disorder in addition to hemophilia A

          -  Markers of hepatic inflammation or overt or occult cirrhosis

          -  History of chronic renal disease or creatinine ≥ 1.5 mg/dL

          -  Presence of liver mass on magnetic resonance imaging (MRI), or, positive alpha
             fetoprotein

          -  Presence of > grade 2 liver fibrosis on elastography for subjects with history of
             treated Hepatitis C or suspicion of chronic liver disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients

Eligibility criteria:
Inclusion Criteria:

          1. 18 years old

          2. Both sexes

          3. Patients that diagnosis in sjogren in treated in Meir Medical center in the years
             2003-2014 And treated in Hydroxychloroquine at least a month.

        Exclusion Criteria:

          1. Minors and special populations

          2. Patients that treated in Hydroxychloroquine at less than a month.

          3. Patient that participate in clinical trial and treat with investigational product
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Can Ideal Mesh Size be Standardized in Open Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Male patients over 18 years of age who applied for inguinal hernia surgery

        Exclusion Criteria:

          -  Patients under the age of 18

          -  Complicated hernias

          -  Recurrent hernias

          -  Those undergoing laparoscopic hernia repair
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment