Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Determining Airway pH by Compartmental Exhaled Nitric Oxide Levels During Alkaline Buffer Challenge

Eligibility criteria:
Inclusion Criteria:

          -  • Study sample will consist of individuals aged 18-60 with a diagnosis of acute or
             chronic respiratory disorders or normal subjects with no pulmonary disease.

        Healthy subjects may include:

          1. Adult males or females age ≥ 18 and ≤ 60 years at time of enrollment

          2. Non-smokers

          3. Person with no history of asthma, chronic obstructive pulmonary disease (COPD), or
             other chronic lung disease

          4. Person with no history of severe allergic/atopic disease requiring immunotherapy or
             immunomodulators

        Subjects with pulmonary disease may include:

          1. Person with well-documented disease with objective diagnostics such a lung function or
             genetic testing.

          2. Person with FEV1 > 55% predicted on the day of study procedures.

          3. Person who is clinically stable with no significant changes in health status within 4
             weeks.

        Exclusion Criteria:

          -  • Subjects that are mechanically ventilated.

               -  Subjects that are unable or unwilling to cooperate with specimen collection.

               -  Subjects with diagnosis of any medical condition that in the investigator's
                  opinion would make them unsuitable for study participation.

               -  Subjects who experienced a pulmonary exacerbation within the 4 weeks prior to
                  visit.

               -  Subjects requiring continuous oxygen therapy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment