Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Treatment With Recombinant Human Growth Hormone Genotonorm (Registered) In Children With Short Stature Secondary

Eligibility criteria:
Inclusion Criteria:

          -  All the patients who have benefit during one year of a treatment by Genotonorm during
             the study 94-8123-014

          -  All patients who have stopped during one year will be included if a signed written
             informed consent

        Exclusion Criteria:

          -  Endocrine disease, except well substituted hypothyroidism

          -  Other severe chronic diseases (e.g. diabetes mellitus, cardiac or liver insufficiency)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effect of Transcutaneous Electric Stimulation on Corneal Nerves and Chronic Ocular Pain

Eligibility criteria:
Inclusion Criteria:

          -  Individuals with dry eye, Ocular pain for more than 3 months, Contact lens users,
             Individuals using topical treatment and/or systemic medication for dry eye syndrome,
             Individuals with history of photo-ablative ocular surgery (Laser-assisted in situ
             keratomileusis (LASIK) , Photorefractive keratectomy (PRK), Small incision lenticule
             extraction(SMILE), Individuals with history of autoimmune disease (Lupus, Rheumatoid
             Arthritis, Sjögrens),

        Exclusion Criteria:

          -  Individuals with pacemakers or implantable defibrillators, Individuals with diagnosis
             of epilepsy, History of facial trauma one month prior to recruitment, Acute facial
             pain with unknown etiology, History of ocular surgery one month prior to recruitment,
             Trigeminal neuralgia, Active Herpes Zoster Ophthalmicus,
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Open-Label Study of ARD-0403 in Testosterone Deficient Men

Eligibility criteria:
Inclusion Criteria:

          -  Testosterone deficiency

          -  Completed study ARD-0403-004

        Exclusion Criteria:

          -  Previous treatment with testosterone replacement therapy within 4 weeks

          -  Moderate-severe benign prostatic hypertrophy or prostatic cancer

          -  Haematocrit >50%
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Esophageal High Resolution Manometry and Dysphagia

Eligibility criteria:
Inclusion Criteria:

          -  Male or female older than 18 years

          -  Patient with unexplained dysphagia

          -  Patient without cause of dysphagia on eso-gastro-duodenal endoscopy

          -  Patient referred for esophageal manometry

          -  Patient with health insurance

          -  Informed consent signed

        Exclusion Criteria:

          -  Patient younger than 18 years

          -  Allergy to one component of manometry catheter

          -  Drug intake which can modify the esophageal motricity within 12 hours preceding the
             realization of the manometry

          -  Patient unable to give his consent or legally incompetent

          -  Patient non qualified according to the investigator

          -  Patient refusal or absence of informed consent signed

          -  Concomitant participation to another study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease

Eligibility criteria:
Inclusion Criteria:

          -  Tympanic membrane perforation without chronic secretion or cholesteatoma

          -  Suspected otosclerosis

        Exclusion Criteria:

          -  Below 12 years of age

          -  Patient not consenting to study

          -  Perioperative findings suggesting chronic otitis or cholesteatoma

          -  Patients not fluent in Norwegian or unable to cooperate in audiometry
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Individualizing Hemophilia Prophylaxis Using Thromboelastography

Eligibility criteria:
Inclusion Criteria:

          -  Males, 5-70 years, inclusive

          -  Plasma FVIII activity <1% documented (Laboratory result or MD documentation of Severe
             Hemophilia A diagnosis)

          -  Currently prescribed prophylaxis treatment regimen infusing ≥3 times a week

          -  Willing to alter their prophylaxis treatment regimen per study protocol

        Exclusion Criteria:

          -  Bleeding disorder(s) other than Hemophilia A

          -  Current inhibitor (>0.6BU)

          -  Thrombocytopenia (platelet count <100,000K/µL since it can alter TEG®/ROTEM® results)

          -  Creatinine >2x the upper limit of normal (indicating potential platelet dysfunction)

          -  Prothrombin time >3 seconds above the upper limit of normal (indicating potential
             liver dysfunction)

          -  Any concurrent clinically significant major disease, frequent bleeding pattern or
             history of non-compliance that, in the opinion of the investigator, would make the
             subject unsuitable for enrollment

          -  Participation within the past 30 days in any other clinical study involving
             investigational drugs

          -  Planned major surgery within 30 days prior to screening or during the study period

          -  Current use of any medication known to have effects on the coagulation system
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Indwelling Pleural Catheter for Trapped Lung

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients, with a clinical confident diagnosis of symptomatic malignant pleural
             effusion, enrolled for VATS exploration but not amenable of VATS talc poudrage because
             of trapped lung (patients with only partial expansion however receiving talc poudrage,
             but needing permanent pleural cathetes, are also eligible)

        Exclusion Criteria:

          -  - Age younger than 18 years

          -  Expected survival of less than 3 months

          -  Chylothorax

          -  Total white blood cell count less than 1000/microL

          -  Pregnancy or lactating mothers

          -  Irreversible bleeding diathesis

          -  Irreversible visual impairment

          -  Contraindications to general anesthesia

          -  Poor general clinical conditions ( ECOG PS >=2)

          -  Patients unable to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Study on Safety and Efficacy of Favipiravir (Favipira) for COVID-19 Patient in Selected Hospitals of Bangladesh

Eligibility criteria:
Inclusion Criteria:

          1. Age: Male or female patients 18 -65 years old

          2. Respiratory samples tested positive for the novel coronavirus.

          3. Initial symptoms will within 7 days

          4. Nonpregnant women (confirmed by urine human chorionic gonadotropin (HCG) test prior to
             enrollment)

        Exclusion Criteria:

          1. Severe clinical condition (meeting one of the following criteria: a resting
             respiratory rate greater than 30 per minute, oxygen saturation below 93%, oxygenation
             index (OI) < 300 mmHg (1 mmHg = 133.3 Pa), respiratory failure, shock, and/or combined
             failure of other organs that required ICU monitoring and treatment).

          2. Chronic liver and kidney disease and reaching end stage. (Serum aspartate
             aminotransferase (AST) and Serum alanine aminotransferase (ALT) will be elevated over
             5 times of normal upper range will excluded).

             (Normal upper limit of Serum AST = 40 units /L, ALT = 56 units /L)

          3. Serum uric acid >7.0 mg/dL in Male and Serum uric acid >6.0 mg/dL in Female will
             excluded

          4. ICU patient

          5. Previous history of allergic reactions to Favipiravir.

          6. Pregnant or lactating women

          7. Women of a childbearing age with a positive pregnancy test.

          8. Miscarriage, or within 2 weeks after delivery

          9. Hypertensive patients, who are taking Calcium Channel Blockers
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Meniere's Disease or Vertigo of Vestibular Origin;

          -  Voluntarily consent to participate in the study;

        Exclusion Criteria:

          -  Female patients who are pregnant or breastfeeding;

          -  Participants presenting uncontroled systolic hipertension (>140/90 mmHg);

          -  Participants presenting uncontroled diabetes (blood glucose >200 mg/dL).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Preliminary Efficacy and Safety of Fispemifene in the Treatment of Hypogonadism: A 4 Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Comparing Daily Oral Doses of 100, 200, and 300 mg Fispemifene and Placebo

Eligibility criteria:
Inclusion Criteria:

          -  Total testosterone level <240 ng/dL

          -  Serum LH and FSH levels within normal limits

        Exclusion Criteria:

          -  Elevated prolactin

          -  Evidence of Benign Prostatic Hypertrophy

          -  History of or current breast cancer, prostate cancer, abnormal DRE or elevated PSA or
             any other malignancy

          -  Clinically significant endocrine/metabolic or cardiovascular disease

          -  Significant polycythemia
Male
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Role of the Microbiota in the Evolution of the SARS-CoV-2 Disease,COVID-19, in Hospitalized Patients

Eligibility criteria:
Inclusion Criteria:

          -  Adult patient with documented SARS-CoV-2 infection requiring hospitalization.

        Exclusion Criteria:

          -  Lack of consent

          -  Patients hospitalized in an intensive care unit

          -  Patient under guardianship or curatorship
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction