Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening

Eligibility criteria:
Inclusion Criteria:

          -  Subject must fail a hearing screening (any threshold >34 decibels hearing level at
             2000 or 3000 Hertz in either ear) or show equivalent or greater degree of hearing loss
             on most recent audiogram.

          -  Free of obvious outer or middle ear disease (as measured by otoscopy)

          -  Between the ages of 45 and 85

          -  Pass a health literacy screening

          -  Pass a thinking skills screening

        Exclusion Criteria:

          -  Experience seeing an audiologist for a hearing evaluation or management

          -  Experience using a hearing aid
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Strontium Ranelate and KOA

Eligibility criteria:
Inclusion Criteria:

        Patients aged ≥ 40 years with symptoms of knee osteoarthritis

        Exclusion Criteria:

        rheumatoid arthritis, spondyloarthropathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 62 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

Eligibility criteria:
Main inclusion criteria include:

          -  Patients diagnosed with laboratory supported probable, clinically probable or definite
             ALS according to the World Federation of Neurology Revised El Escorial criteria

          -  Patient with a familial or sporadic ALS

          -  ALS disease duration from diagnosis no longer than 24 months at the screening visit

          -  Patient treated with a stable dose of riluzole (100 mg/day) for at least 12 weeks days
             prior to the baseline visit

          -  Patient with an ALSFRS-R score progression between onset of the disease and screening
             of > 0.3 per month, confirmed with an ALSFRS-R score progression of ≥ 1 point during a
             12-week run-in period between screening and randomization.

          -  Patient with a score, at screening, of at least 26 overall, including a score of at
             least 3 on item #3 and at least 2 on each of the 12 ALSFRS-R individual component
             items and with a score, at randomization, of at least 2 on each of the 12 ALSFRS-R
             individual component items

        Main exclusion criteria include:

          -  Patient with dementia or significant neurological, psychiatric, systemic or organic
             disease, uncontrolled or that may interfere with the conduct of the trial or its
             results

          -  Patient with a FVC < 60% predicted normal value for gender, height, and age at
             screening and baseline

          -  Pregnant, or nursing female patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 81 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Activity Behaviours in Patients With Malignant Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Patients with an MPE (i.e. one in which malignant cells are identified in the pleural
             fluid or pleural biopsy); or a large exudative pleural effusion without other causes
             in a patient with known disseminated extra-thoracic malignancy

        Exclusion Criteria:

          -  Patients with Age <18 years; pleural infection; pregnant or lactating; inability to
             consent or comply with the protocol; anticipated pleural drainage procedure within one
             week subsequent to recruitment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Program of Physical, Nutritional and Psychological Activities With Overweight Schoolchildren

Eligibility criteria:
Inclusion Criteria:

          -  Are regularly enrolled in municipal schools in the city of Petrolina-Pernambuco;

          -  They are classified as overweight or obese according to the criteria used by the
             researchers;

          -  Do not present restrictions to the practice of physical activities;

          -  Do not use medications that may interfere with your search results.

        Exclusion Criteria:

          -  That they refuse to participate at some point in the data collection;

          -  That they have some restriction to the practices developed in the research, acquired
             during the course of the study;

          -  That they present a number greater than 50% of absences in the proposed activities;

          -  That parents or guardians miss four meetings or more.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 9 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Effectiveness of Additional Self-care Acupressure for Women With Menstrual Pain Compared to Usual Care Alone

Eligibility criteria:
Inclusion Criteria:

          -  Women with dysmenorrhea as defined as cramping pain during every menstrual cycle

          -  Age: 18 to 25 years

          -  Up to now no prior history of a gynecological disease that could be a reason for
             dysmenorrhea

          -  Women with menstruation in the last six weeks and a duration of menstruation cycles
             between 3 and 6 weeks

          -  Women with moderate and severe pain defined as a score equal or higher than 6 on the
             numeric rating scale for the worst pain intensity during the last menstruation.

          -  Written and oral informed consent

          -  Women must be able to complete the baseline questionnaire in paper form, the
             electronic questionnaire via App and a electronic diary via App.

          -  Presence of a Smartphone and agreement to do data entry through the App

        Exclusion Criteria:

          -  Acupressure, acupuncture, shiatsu- or/and tuina massage at the moment or planned in
             the next 8 months

          -  Known or planned pregnancy in the next 8 months.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Outcome Measures in Infant/Early Childhood Lung Disease w/ Chest CT Scanning & Lung Function Testing

Eligibility criteria:
Inclusion Criteria:1) Infants and young children (age <= 3 months to < 5 years) and either
        2) or 3) below.

        2) Respiratory condition (e.g. cystic fibrosis (CF), primary ciliary dyskinesia,
        bronchopulmonary dysplasia, asthma, or other pulmonary condition) and under the care of a
        pediatric pulmonologist at LPCH.

        3) Oncology condition (e.g. young children with or without cancer, who are being screened
        for lung metastasis) and are being followed by pediatric oncologists at LPCH.

        4) For minors, informed consent by parent or legal guardian.

        5) Ability to comply with study visit procedures as judged by the investigator. Exclusion
        Criteria:1) Acute wheezing and/or respiratory distress at Study visit.

        2) Acute intercurrent respiratory infection, defined as an increase in cough, wheezing, or
        respiratory rate with onset in 1 week preceding Study visit.

        3) Oxygen saturation < 90% on room air at study visit.

        4) Any medical condition that in the opinion of the investigator precludes subject
        participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 5 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Corpus Luteum and Uterine Artery Doppler With Serum P and CA125 in Threatened Abortion

Eligibility criteria:
Inclusion Criteria:

          -  patients with pregnancy between 8 to 20 weeks of gestation,

          -  who were diagnosed with threatened abortion.

        Exclusion Criteria:

          -  patients with multiple pregnancies,

          -  molar pregnancy,

          -  ectopic pregnancy,

          -  amenorrhea with different etiologies of pregnancy,

          -  maternal history of systemic diseases and uterine anatomic abnormalities

          -  patients who did not have their outcome data through week 20 of gestation due to
             relocation.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa

Eligibility criteria:
Inclusion criteria:

          -  PLHIV without antiretroviral therapy but with COVID-19 infection

          -  PLHIV with antiretroviral therapy and COVID-19 infection

          -  HIV-negative patients, sex- and age matched, infected with COVID-19;

          -  older than 18 years

        Exclusion criteria:

          -  Those with known co-infections such as hepatitis B and C

          -  with a viral load of HIV RNA >1000 copies/ml under ART or with advanced symptoms of
             AIDS

          -  negative for SARS-CoV-2 RNA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Amphiregulin Versus Non-Amphiregulin Supplementation to Maturation Culturing Medium in IVM.

Eligibility criteria:
Inclusion Criteria:

          -  Having polycystic ovarian morphology: at least 25 follicles (2-9 mm) throughout the
             whole ovary and/or increased ovarian volume (>10ml) (it is sufficient that 1 ovary
             fits these criteria)

          -  No major uterine or ovarian abnormalities

        Exclusion Criteria:

          -  Medical contra-indication for pregnancy

          -  High (>grade 2) grade endometriosis

          -  Cases with extremely poor sperm (OAT)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction