Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Effect of Low Intensity Ultrasound Therapy on Chronic Pain Due to Osteoarthritis of the Knee.

Eligibility criteria:
Inclusion Criteria:

          1. Osteo-arthritis of knee joint diagnosed through X-Ray evaluation

          2. Moderate or sever level of pain due to knee osteoarthritis and no other known reason

          3. Male of Female patients of 18 to 85 years old

          4. Pain interfering with activities of daily life

        Exclusion Criteria:

          1. Cancer pain or any other concurrent cancerous condition

          2. History of Knee replacement surgery in the study joint

          3. Local infection or any kind of inflammatory or allergic skin lesion

          4. Rheumatoid arthritis

          5. Mobility disorders or not being able to walk
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study

Eligibility criteria:
Inclusion Criteria:

          -  to present with GI symptoms that are secondary to EMD such as dysphagia, regurgitation
             and/or non-cardiac chest pain.

          -  the EMD patients to be recruited under this study are achalasia type I, II and III;
             OGJ outflow obstruction; distal oesophageal spasm, hypercontractile oesophagus or
             disorders not fulfilling Chicago Criteria v3.

          -  Receive a treatment such as POEM, neumatic dilatation, LHM, botox injection.

        Exclusion Criteria:

          -  Exclusion criteria are the inability to fill in symptom questionnaires, intolerance of
             pre or post procedure test, incomplete therapeutic procedures or technical failure of
             baseline manometry investigation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-35

          -  Normal menstrual periods (24-35 days)

          -  Good general health

          -  Willing to use a non-hormonal form of contraception for the entire study (Acceptable
             forms of contraception include condoms, spermicide, sexual contact with a sterilized
             partner, subject is surgically sterile, same-sex partner, Copper IUD and abstinence)

          -  Willing and able to return to clinic for bi-weekly blood tests

        Exclusion Criteria:

          -  Pregnant or breast feeding

          -  Polycystic ovarian disease

          -  Gastrointestinal conditions (i.e.gastric ulcer)

          -  Currently using birth control

          -  Known allergy to aspirin, non-steroidal anti-inflammatory drugs (NSAIDS) or
             Sulfa-drugs

          -  Diabetes

          -  Cardiac disease or hypertension

          -  Moderate to severe heartburn (GERD)

          -  Obesity (BMI greater than 30)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Lcr35 for Children With Functional Constipation

Eligibility criteria:
Inclusion Criteria:

          -  Children below 5 years of age

          -  Functional constipation according to Rome III criteria i.e. 1 month of at least 2 of
             the following:

               -  Two or fewer defecations per week

               -  At least 1 episode per week of incontinence after the acquisition of toileting
                  skills

               -  History of excessive stool retention

               -  History of painful or hard bowel movements

               -  Presence of a large fecal mass in the rectum

               -  History of large- diameter stools that may obstruct the toilet

        Exclusion Criteria:

          -  Irritable bowel syndrome

          -  Mental retardation

          -  Endocrine disease (e.g. hypothyroidism)

          -  Organic cause of constipation (e.g. Hirschsprung disease)

          -  Spinal anomalies

          -  Anatomic defects of the anorectum

          -  History of previous gastrointestinal surgery

          -  Functional nonretentive fecal incontinence

          -  Use of drugs that influence gastrointestinal motility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 5 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo

Eligibility criteria:
Inclusion Criteria:

          -  hand arthritis

          -  pain over 40/100

          -  stable treatment since 4 weeks at least with non-steroid analgesic

          -  between 45 et 85 years

        Exclusion Criteria:

          -  pregnancy or breast feeding women

          -  hyaluronic acid injection within the past 6 months

          -  cortisonic derivated injection within the past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: A Prospective Cohort Study for Patients With Adrenal Diseases

Eligibility criteria:
Inclusion Criteria:

          -  Adults, male or female aged 19 years or older

          -  newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma,
             primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma

        Exclusion Criteria:

          -  previous or current history of adrenal diseases

          -  using oral or intravenous steroids

          -  history of major depressive disorder

          -  history of chronic alcoholics

          -  history of any cancer with suspicious adrenal metastasis

          -  those with acute illness (ex- patients with acute coronary syndrome within 4 weeks,
             acute febrile disease)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Both ovaries are present

          -  Day 2 FSH <10 mIU/L

          -  Day 2 Estradiol <50 pg/L

        Exclusion Criteria:

          -  Polycystic ovarian syndrome (PCOS)

          -  Abnormalities affecting the uterine cavity

          -  Uncontrolled diabetes

          -  Allergy to gonadotrophins

          -  Cancelled cycles during the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Pulsed Dye Laser (PDL) vs. Microsecond 1064-nm Nd:YAG Laser for Treatment of Diffuse Facial Redness

Eligibility criteria:
Inclusion Criteria:

          -  Healthy patients 18-55 years of age with erythematotelangiectatic rosacea (as verified
             by the the PI).

          -  Subjects who are willing to provide informed consent for participation in the study.

        Exclusion Criteria:

          -  Pregnant or lactating individuals

          -  Subjects who are unable to understand the protocol or to give informed consent.

          -  Subjects who have a known history of photosensitive conditions (e.g. Systemic lupus,
             polymorphous light eruption)

          -  Subjects who have facial telangiectasia of diameter greater than 2 mm.

          -  Subject who have significant (as determined by the PI) acute inflammatory papules,
             pustules, and vesicle involving the central face.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Degree-of-worry and Illness Perception in Patients Suffering From Acute Illness in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  ≥18 years of age

          -  cognitively intact

          -  consent to participation.

        Exclusion Criteria:

          -  patients arriving to the ED regarding injury

          -  patient with the highest triage level

          -  demented patients

          -  intoxicated patients
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Management of Acute Pain in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

        Any patient admitted to our Emergency Department who is

          -  age > 16 years

          -  pain lasting =< 1 week or

          -  no pain on admission but pain during the ED stay

        Exclusion Criteria:

          -  life-threatening condition requiring immediate admission in the OR or ICU

          -  no pain or pain lasting >1 week

          -  inability to give informed consent (intoxicated, psychiatric disorder, language
             problem, prisoner)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction