Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Hypermetabolism in ALS Using Six REE Formulas

Eligibility criteria:
Inclusion Criteria:

          -  ALS patients

          -  18 years old or more

          -  IC and nutritional assessment within 1.5 months

          -  delay between diagnosis and IC < 12 months

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Impact of the Combined Treatment of Liposomed Polyphenols With Dutasteride on the ALS Patients

Eligibility criteria:
Inclusion Criteria:

          -  All ALS patients, over 18 years of age and with a clear diagnosis and symptomatology
             of ALS since at least 6 months.

        Exclusion Criteria:

          -  Women under 50 years of age and childbearing age.

          -  Tracheotomy patients.

          -  Patients with invasive or non-invasive ventilation with positive ventilatory pressure

          -  Gastrectomized patients.

          -  Patients with evidence of dementia.

          -  Patients with alcohol or drug abuse dependency.

          -  Patients infected with B or C hepatitis, or HIV positive

          -  Renal patients with creatinine levels twice as high as normal markers.

          -  Liver patients with liver markers (ALT, AST) elevated 3 times above normal levels.

          -  Patients included in other research with drugs or therapies in the experimental phase.

          -  Patients treated with anticoagulants or with haemostatic problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Non-exposure Simple Suturing EFTR (NESS-EFTR) With Laparoscopic Sentinel Lymph Node Navigation for EGC (Senorita3-phase 2)

Eligibility criteria:
Inclusion Criteria:

          -  single lesion of adenocarcinoma in preoperative endoscopic biopsy

          -  clinical stage T1N0 in the preoperative evaluation of endoscopy and computed
             tomography

          -  tumor size: less than 3cm

          -  location: 3cm far from the pylorus or cardia

          -  aged 20 to 80

          -  ECOG 0 or 1

          -  patient who signed the agreement

          -  patient who is suspected to underwent laparoscopy assisted gastrectomy

        Exclusion Criteria:

          -  absolute indication of endoscopic submucosal resection

          -  inoperable due to poor cardiac, pulmonary function

          -  pregnant

          -  having allergic reaction, previous upper abdominal surgery except laparoscopic
             cholecystectomy, previous radiation therapy to upper abdomen

          -  diagnosed as malignancy within 5 years except carcinoma in situ of cervix cancer and
             thyroid cancer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Diagnostic Suspicion of Primitive Syndrome Sjögren's : Brest Cohort

Eligibility criteria:
Inclusion Criteria:

          -  Patients with suspected pSS underwent a standardised evaluation

        Exclusion Criteria:

          -  Opposition of patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Bystanders' Exposure to Electronic Cigarette Aerosol in Confined Settings

Eligibility criteria:
Inclusion Criteria:

        For e-cigarette non-users

          -  Adult (18 years old and above)

          -  Non-e-cigarette user (never user or more than 6 months former e-cigarette user)

          -  Non-smoker or user of any kind of tobacco/nicotine product (never or ex-smoker for >6
             months)

          -  Not being regularly exposed to cigarettes or e-cigarettes at home or other settings

        For the e-cigarette user

          -  Adult (18 years old and above)

          -  Daily user of e-cigarettes (at least 2 months)

          -  Non-user of any other tobacco/nicotine products for at least 2 months

        Exclusion Criteria:

        For all participants:

          -  Pregnancy or breastfeeding

          -  Ongoing or recent illness (<4 weeks prior to the study)

          -  Acute or chronic condition or disease (diabetes, asthma, COPD, congenital heart
             disease, arrhythmia, hypertension or other)

          -  Any type of medication (<2 weeks prior to the study)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Influence on Human Male Fertility of Testosterone After Intranasal (MPP10) or Transdermal (AndroGel™) Application

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than or equal to 50 years but not older than 80 years of age;

          -  Serum testosterone level <13.8 nmol/l;

          -  Sperm concentration > 40 Million/ml;

          -  Willing to give written informed consent.

        Exclusion Criteria:

          -  Testicular diseases or having had any surgical procedures applied to the testes;

          -  History or currently existing serious disease of any type, in particular liver, kidney
             or heart disease, any form of diabetes mellitus, cancer or psychiatric illness;

          -  Current androgen, anabolic steroid or sex hormone treatment or any treatment with such
             compounds in the previous 6 months;

          -  Blood donation within the 12-week period before the initial study dose.

          -  History of, or current nasal disorders (e.g. seasonal or perennial allergic rhinitis,
             atrophic rhinitis, polyposis, abuse of nasal decongestants, clinically relevant nasal
             septum deviation, recurrent epistaxis) or sleep apnea;

          -  Elevated serum PSA levels (> 4 ng/ml for subjects >= 50 years of age);
Male
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Laparoscopic Versus Open Mesh Repair of Bilateral Primary Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with painless uncomplicated primary bilateral inguinal hernias

        Exclusion Criteria:

          -  Immune compromised patients

          -  Coagulopathy

          -  Chronic liver or renal disease

          -  High-risk patients unfit for major surgery (ASA III or IV),

          -  Massive scrotal hernias, Recurrent or Complicated hernias

          -  Groin pain due to any other pathology

          -  Previous infra-umbilical surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis

Eligibility criteria:
Inclusion Criteria:

          -  Men, at least 18 years old

          -  hereditary hemochromatosis C282Y homozygous diagnosed and followed in the service of
             Liver Diseases, University Hospital of Rennes

          -  Maintenance therapy with phlebotomy for at least 1 year with stable iron stock on the
             basis of at least four previous plasma ferritin < 50μg / L,

          -  Written, free and informed consent

        Exclusion Criteria:

          -  Intercurrent illness unrelated to hemochromatosis causing cytolysis or inflammatory
             reaction.

          -  Person with a measure of legal protection (guardianship)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods

Eligibility criteria:
Inclusion Criteria:

          -  Women with no desire to preserve their fertility who have heavy menstrual bleeding
             without organic pathology (DUB) of more than six months duration

          -  Premenopausal follicular follicle stimulating hormone (FSH) level of less than 40
             IU/L.

          -  Associated functional disability (negative impact on life quality).

          -  Lack of response to medical treatment.

          -  Prepared to undergo surgical treatment without general anaesthesia

        Exclusion Criteria:

          -  Women under 25 years

          -  Suspected genital tract infection

          -  Uterine pathology including endometrial pathology on endometrial biopsy (e.g.
             endometrial hyperplasia or carcinoma) and structural lesions (e.g. uterine
             malformations, adhesions, polyps, submucous fibroids or extracavity fibroids > 3cm in
             diameter) as identified on pelvic ultrasound and/or outpatient hysteroscopy.

          -  Uterine cavity length >11cm

          -  Adnexal pathology

          -  Previous open myomectomy or endometrial ablation / resection and classical caesarian
             section

          -  patients considered vulnerable (e.g. current mental illness, emotionally labile,
             learning difficulties, immaturity)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Effects of Lumbar Traction on the Straight Leg Raise Test and Pain

Eligibility criteria:
Inclusion Criteria:

          -  Back pain for less than 3 months

          -  Positive unilateral Straight Leg Raise test which includes reports of back and leg
             pain or paraesthesia below 45-degree hip flexion

          -  At least one additional neurological sign should be present including- (a) Diminished
             Achillis/Hamstring tendon reflex, tested in the supine position or (b) Hyposthesia in
             any of the L4-S2 dermatome, or (c) Muscle weakness in any of the L4-S2 myotome.

          -  MRI evidence of L-4-L5 or L5-S1 disc prolapse or both.

        Exclusion Criteria:

          -  Malignancy, Tuberculosis, Osteoporosis, Osteomyelitis of the vertebral column

          -  Cord compression, Pregnancy, Hypertension, Cardiovascular disease, Joint hyper
             mobility

          -  Subjects who could not tolerate the traction force secondary to being in an acute
             stage of back pain.

          -  Subjects who have taken previous physiotherapy treatment in the last three months for
             back pain.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction