Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Pharmacokinetic And Pharmacodynamic Study Of A Single-Dose Of PF-04950615 (RN316) In Combination With Atorvastatin

Eligibility criteria:
Inclusion Criteria:

          -  On stable doses of atorvastatin (40 mg daily) for 45 days prior to Day 1.

          -  BMI 18.5 to 40 kg/m2 inclusive, and body weight equal or lower than 150 kg.

        Exclusion Criteria:

          -  History of a cardiovascular event (e.g., MI ) during the past year.

          -  Poorly controlled Type 1 or Type 2 Diabetes mellitus (definition: uncontrolled
             diabetes is defined as HBIAc >9%).

          -  Poorly controlled hypertension (uncontrolled hypertension is defined as a systolic
             blood pressure greater than 140 mm Hg or a diastolic blood pressure greater than 90 mm
             Hg, even with treatment). Subjects who have hypertension and are controlled on stable
             dosages of anti-hypertensive medications can be included.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Effects of Local Anesthesia on Post-operative Pain During Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 or older with unilateral or bilateral inguinal herna for laparoscopic repair

          -  American Society of Anesthesiology (ASA) Class I and II

        Exclusion Criteria:

          -  Conversion from laparoscopic to open surgery

          -  History of Chronic pain or ongoing treatment for chronic pain

          -  Age less than 18 yrs

          -  Allergy to local anesthetics
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Pain and Convalescence After Laparoscopic Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  planned laparoscopic inguinal or femoral herniorrhaphy

          -  ASA class I-II

          -  speak and read danish

        Exclusion Criteria:

          -  converting to open operation

          -  low compliance (dementia, psychiatric disorder)

          -  use of morphine or similar drugs daily in the last month

          -  complications to the operation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Mitochondrial Functions and Oxidative Stress in ALS Patients

Eligibility criteria:
Inclusion Criteria:

          -  male or female

          -  age > 30 years

          -  definite or probable ALS according to the El Escorial criteria, bulbar or spinal form,
             ALS diagnosis < 1 year and treatment by riluzole.

        Exclusion Criteria:

          -  family history of ALS,

          -  oral, enteral or parenteral nutritional supply,

          -  vitamin or trace element supplementation

          -  confusing illness (cancer, diabetes, chronic infectious or inflammatory
             disease,thyroid disorders, recent surgery...),

          -  current tobacco use,

          -  alcoholism

          -  treatment by corticosteroids,

          -  diuretics,

          -  anorectics

          -  NSAIDs

          -  cytotoxics

          -  anticoagulants...
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Outcome After MTX & Transvaginal Surgery or UAE & Uterine Curettage in Patients With Cesarean Scar Pregnancy

Eligibility criteria:
Inclusion Criteria:

        Increased levels of serum β-hCG and ultrasonography findings. The criteria for diagnosis by
        ultrasonography was the presence of the following: (1) an empty uterine cavity and
        endocervical canal; (2) detection of the placenta and/or a gestational sac embedded in the
        hysterectomy scar; (3) the presence of the gestation sac with or without a fetal pole and
        with or without fetal cardiac activity (depending on the gestational age) in the anterior
        part of the uterine isthmus; and (4) a thin (1-3 mm) or absent myometrial layer between the
        gestational sac and the bladder. All patients had taken Magnetic Resonance Imaging (MRI) to
        clarify the diagnosis . Pregnancy tissues were identified by histopathology examinations of
        the surgical tissues.

        Exclusion Criteria:

        All enrolled patients had no contraindications for transvaginal surgery or UAE, including
        renal failure, active pelvic infection, clotting disorders, or known allergy to the
        contrast material.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: PI3Kβ Selective Inhibitor With Paclitaxel, Advanced Gastric Adenocarcinoma

Eligibility criteria:
Inclusion criteria:

          1. histologically or cytologically confirmed diagnosis of advanced gastric adenocarcinoma

          2. Has a PTEN-deficient tumor as documented from archival or fresh (from biopsy) tumor
             tissue or has shown genomic alterations in PI3K pathway genes (PIK3CB, PI3KR1, PTEN,
             etc.) as assessed in a local laboratory.

          3. Has had no prior taxane exposure (preferred) or at least 6 months since last taxane
             exposure.

          4. Eastern Cooperative Oncology Group performance status of 0 or 1

          5. measurable or evaluable disease as determined by RECIST 1.1.

          6. Is able to swallow and retain orally administered medication

          7. adequate baseline organ function

        Exclusion criteria

          1. prior treatment with any AKT, mammalian target of rapamycin (mTOR) inhibitors or PI3K
             pathway inhibitors

          2. Has any unresolved Grade 2 (per CTCAE v4.0) toxicity from previous anti-cancer therapy
             at the time of enrollment such as neuropathy, except alopecia or Grade 2 anemia (if
             hemoglobin is ≥9.0 g/dL)

          3. Has CNS metastases

          4. Has a QTc interval >450 msec or QTc >480 msec for subjects with bundle branch block
             (BBB)

          5. Has a known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
             chemically related to GSK2636771 or hypersensitivity to drug formulated in polyoxyl 35
             castor oil, NF such as paclitaxel.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Linear Endosonography for the Assessment of Sarcoidosis Stage O

Eligibility criteria:
Inclusion Criteria:

          -  Patient referred to bronchoscopy for tissue diagnosis of discrete enlarged (≥10mm
             short axis diameter) mediastinal/hilar lymph nodes on CT scan that can be sampled by
             E(B)US-NA.

        Exclusion Criteria:

          -  Abnormal chest X-ray showing hilar/mediastinal lymph nodes

          -  Patients with suspected lung cancer

          -  Patients with previous malignancy diagnosed and definitely treated less than 5 years
             previously or, if treated more than five years before but with subsequent evidence of
             recurrence less than 5 years previously.

          -  Patient with concomitant (suspected or confirmed) bronchopulmonary infection or
             treated with antibiotics within the 4 previous weeks

          -  Patients with a contraindication for bronchoscopy and tissue sampling
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Pleural Disease: Phenotypes, Diagnostic Yield and Outcomes

Eligibility criteria:
Inclusion Criteria:

          -  The subject must meet all of the following inclusion criteria to participate in this
             study.

               1. Evidence of pleural disease on chest radiograph or bedside ultrasound or Computed
                  Tomography regardless of underlying aetiology

               2. No age or gender restrictions

               3. Ability to provide informed consent

        Exclusion Criteria:

          -  Subjects who no radiographic evidence of pleural disease or who are unwilling/unable
             to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Trial of An Innovative Smartphone Intervention for Smoking Cessation

Eligibility criteria:
Inclusion Criteria:

          -  age 18 or older

          -  smokes at least five cigarettes daily for at least past 12 months

          -  wants to quit cigarette smoking in the next 30 days

          -  if concurrently using any other nicotine or tobacco products, wants to quit using them
             within the next 30 days

          -  interested in learning skills to quit smoking

          -  willing to be randomly assigned to either condition

          -  resides in US

          -  has at least daily access to their own personal Apple iPhone, Android, or Windows
             Phone

          -  knows how to login and download a smartphone application

          -  willing and able to read in English

          -  not using other smoking cessation interventions (including apps or our other
             intervention studies).

          -  willing to complete all three follow-up surveys

          -  provide email, phone, and mailing address.

        Exclusion Criteria:

          -  The exclusion criteria are opposite of the inclusion criteria listed above.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: NICE Guideline 'Red Flags' to Predict Serious Outcome After Transient Loss of Consciousness

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (>= 16 years) with a complaint of TLoC

        Exclusion Criteria:

          -  Patients needing immediate treatment, with trauma related or drug or alcohol related
             TLoC were excluded, as well as patient with persistent altered level of consciousness,
             simple fall and drop attack
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment