Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Clinical Application of Non-invasive PGT-A

Eligibility criteria:
Inclusion Criteria:

          -  Infertile women who undergo IVF with PGT

          -  BMI:18~30 kg/m2

        Exclusion Criteria:

          -  Primary ovarian insufficiency

          -  Congenital uterine anomaly

          -  Severe male infertility (azoospermia)

          -  One of the couples with chromosome abnormality

          -  Malignancy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 44 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Vibration and Cold for Pain Relief During Peripheral Intravenous Cannulation in Children With Intellectual Disability

Eligibility criteria:
Inclusion Criteria:

          -  Age 4 to 17 years

          -  Presence of intellectual disability

          -  Need of peripheral IV line or venipuncture

          -  Informed consent signed by parents or legal guardians

        Exclusion Criteria:

          -  Presence of abrasion, infection or break in skin in the area of Buzzy® placement

          -  Cold hypersensibility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Predictors of Driving Performance and Successful Mobility - Rehabilitation in Patients With Medical Eye Condition

Eligibility criteria:
Eye impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Sensory Training for Orientation and Balance

Eligibility criteria:
Inclusion Criteria:

          -  Participants must have self-reported symptoms of visually-induced dizziness

          -  Participants must have normal self-reported cognitive function

          -  Participants must speak English fluently

          -  Weigh less than 225 pounds

          -  Be able to support their body weight in an upright posture for 15 minutes at a time

          -  Be able to follow the guidelines regarding permitted and prohibited additional
             treatments outlined in the study protocol.

        Exclusion Criteria:

          -  Participants must not be participating in vestibular and balance rehabilitation
             therapy

          -  Pregnant or planning to become pregnant while in "on study" status

          -  Best-corrected visual acuity > 20/70

          -  Any self-reported, uncompensated, binocular vision abnormality, such as strabismus,
             amblyopia, or diplopia

          -  Peripheral neuropathy

          -  Self-reported history of frequent syncope (>1/month).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 59 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: Development and Validation of a Regional Multi-scale System for the Prediction of the Patient Flow in the Emergencies and the Need for Hospitalization

Eligibility criteria:
Inclusion Criteria:

          -  All subjects have been recorded as patients in emergency departments between 2010 and
             2015.

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Cardiovascular Risk Factors in Overweight Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  Overweight and obese adolescents in the Trondheim area, referred to medical treatment
             at St. Olav's Hospital

        Exclusion Criteria:

          -  Any coexisting medical illnesses
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Family SuppleMented pAtient monitoRing afTEr suRgery: A Pilot Trial

Eligibility criteria:
Inclusion Criteria:

        Patients:

        • Patients ≥5 years of age undergoing surgery at Mbale Regional Referral Hospital, who
        receive post-operative care in one of four main surgical wards, with a family carer
        prepared to participate in the trial intervention.

        Carers:

          -  All carers will be included in the trial if they feel they are capable of performing
             and documenting the basic vital signs provided they agree to participate in the trial.

          -  The ability to speak English, Luganda, Lugisu, Ateso or Lugwere

          -  The ability to read a digital clock (to measure vital signs)

          -  Numeracy sufficient to write numbers on the basic observation chart

        Exclusion Criteria:

        Patients:

          -  Refusal of informed consent.

          -  Identification of potential participant >24hours after operative procedure has taken
             place

        Carers:

        • Refusal of informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Effectiveness and Adherence to Closed Face Shields to Prevent COVID-19 Transmission

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or older

          -  Negative RT-PCR test at the beginning of the study.

          -  Negative SARS-CoV-2 serological Elecsys Anti-Sars-CoV-2 test at the beginning of the
             study.

          -  Living in a geographic area with active COVID-19 transmission (number of

          -  cases reported locally).

          -  Living in a geographic area that has been determined by the Colombian National
             Statistics Department (DANE) to have a medium, medium-high, and high vulnerability
             index (higher prevalence of comorbidities and social and economic vulnerabilities.

          -  Working outside the home for at least two days a week, during the last week.

          -  Acceptance to participate in the study regardless of the trial arm assignment through
             verbal informed consent.

        Exclusion Criteria:

          -  Retired adults or unemployed

          -  Adults referring previous diagnosis of COVID-19 confirmed by RT-PCR tests or
             serological antibody tests.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Laparoscopic Hernia Repair With Lateral Umbilicus Ligament for Children

Eligibility criteria:
Inclusion Criteria:

          -  unilateral inguinal hernia

          -  age between 2 years and 17 years

          -  no history of abdominal or inguinal operations

          -  the age range was based on the day surgery criteria of our hospital

          -  of male patients, only those with completely descended testes were included

        Exclusion Criteria:

          -  the bilateral hernia

          -  the recurrence hernia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

        Suspected adrenocorticotropin hormone (ACTH)-dependent Cushing's syndrome No pregnant women
        Effective contraception required of fertile women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Survey of Inhibitors in Plasma-Product Exposed Toddlers

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects

          -  Any ethnicity

          -  Age <6 years

          -  Severe haemophilia A (FVIII:C <1%), as confirmed at enrolment by the central
             laboratory.

             o Those patients diagnosed locally as severe but subsequently found to have FVIII
             levels >= 1% on testing at the central laboratory will be separately recorded in the
             screening list.

          -  Previously untreated (0 EDs to any FVIII concentrates or blood products) or minimally
             treated (<5 EDs) with blood components, namely whole blood, fresh frozen plasma,
             packed red blood cells, platelets or cryoprecipitate.

             o Patients not meeting these criteria will be separately recorded in the screening
             list.

          -  Negative inhibitor measurement at both local and central laboratory at screening

          -  Ability to comply with study requirements

          -  Signed informed consent of legal tutors o Patients who will not accept to enter into
             the study or to be randomized will be separately recorded.

        Exclusion Criteria:

          -  Previous history of FVIII inhibitor

          -  Other congenital or acquired bleeding defects

          -  Plasma FVIII level >= 1%, as assayed at the central laboratory

             o Those patients originally diagnosed locally as severe but subsequently found to have
             FVIII levels ranging from 1% to 2% on testing at the central laboratory will be
             separately recorded in the screening list.

          -  Concomitant congenital or acquired immunodeficiency

          -  Concomitant treatment with systemic immunosuppressive drugs

          -  Concomitant treatment with any investigational drug
Male
No healthy subjects accepted to join the trial.

Subject must be at most 6 Years

Eligibility (NLI label): Contradiction