Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Electromoxibustion and Knee Health Education for Knee Osteoarthritis in Older Adults

Eligibility criteria:
Inclusion Criteria:

          1. ethnic Chinese;

          2. aged 60 years or above;

          3. ability to comprehend Chinese;

          4. fulfilling any 3 of the following criteria: i. morning stiffness </= 30 min; ii.
             crepitus on active joint motion; iii. bone tenderness; iv. bone enlargement; or v. no
             palpable joint warmth (This classification yielded 84% sensitivity and 89% specificity
             for OA knee diagnosis (Altman et al., 1986);

          5. having knee pain for at least 3 months;

          6. Knee pain ≥4 on a Likert pain scale from 1-10; and

          7. willing to provide informed consent.

        Exclusion Criteria:

          1. medical diagnoses or conditions that preclude individuals from active participation
             (e.g. dementia, post-stroke syndrome, alcohol or drug abuse);

          2. knee pain related to other conditions (cancer, fracture, rheumatoid arthritis,
             rheumatism) as screened according to the red flags for further investigation or
             referral in the National Clinical Guideline Centre 2014 Guidelines for Osteoarthritis
             of the knee (National Clinical Guideline Centre, 2014);

          3. presence of skin lesions or infections at the treatment sites;

          4. ever had knee replacement surgery or knee joint implant; and

          5. ever received moxibustion, electromoxibustion or steroid injection for knee pain over
             the past 6 months; Further investigation or referral, either at the screening or
             during the study, will be made when necessary.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Factors Influencing Fertility or Pregnancy Health

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  healthy white women aged 21-42 who were planning to become

        pregnant

        -women enrolled in the 1982-1986 North Carolina Early Pregnancy

        Study (EPS) at the time they discontinued all methods of birth control
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Females With Severe or Moderate Hemophilia A or B: an International Multi-center Study

Eligibility criteria:
Inclusion Criteria:

          -  Females with severe (FVIII<0.01u/ml) or moderate (FVIII 0.01≤0.05 u/ml) hemophilia A

          -  Females with severe (FIX<0.01u/ml) or moderate (FIX 0.01≤0.05u/ml) hemophilia B

          -  Willingness to participate in the study.

        Exclusion Criteria:

          -  Subjects who do not meet the inclusion criteria with respect to gender or hemophilia
             severity.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Effect of Swimming on Premenstrual Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. virgins.

          2. Their age ranged from 18 to 25 years old

          3. Their body mass index (BMI) ranged from 18 to 25 kg/m2.

          4. They were clinically and medically stable during the study

          5. Have regular menstrual cycle of 23 to 35 days duration

        Exclusion Criteria:

          1. cardiopulmonary or orthopaedic problems

          2. women taking any hormonal drugs or drugs that affect hormones as antidepressnats
             during the preceding 3 months before participation in the study

          3. any abnormality in ovulation or those with pelvic inflammatory diseases (PID).

          4. Women with endocrine abnormality as thyroid, pituitary or ovarian disorders
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Haemophilia Patients With Inhibitors Being Treated for Acute Joint Bleeds

Eligibility criteria:
Inclusion Criteria:

          -  12 years of age or older (at least 18 years in Croatia, France and United Kingdom
             (UK))

          -  Clinical diagnosis of congenital haemophilia A or B with a current positive inhibitor
             titre and a known peak inhibitor of above 5 Bethesda units (BU) (present or in the
             past) to human FVIII or IX and known antihuman FVIII or IX anamnestic response

          -  Minimum of 2 joint bleeds (haemarthroses of ankles, knees, or elbows) requiring
             haemostatic drug treatment within the previous 6 months, or at least 4 joint bleeds
             (hemarthroses of ankles, knees, or elbows) requiring haemostatic drug treatment within
             the previous 12 months at trial entry

        Exclusion Criteria:

          -  Known allergy to rFVIIa, and/or suspected allergy to trial product

          -  Platelet count lower than 50,000 mm^3 based on medical records at trial entry (visit
             1)

          -  Any clinical signs or history of thromboembolic events

          -  Advanced atherosclerotic disease

          -  Severe liver disease based on medical records within the past 12 months at trial entry
             (Visit 1), as defined by alanine aminotransferase (ALAT) above 3 times the upper limit
             of normal reference range

          -  Known active pseudo tumours (documented bleeding requiring treatment within the last 3
             months

          -  Subject had any (major) surgical procedure in the 30 days prior to screening into the
             trial. a. Catheter, ports and dental extractions do not count as surgeries and will
             not exclude the subject
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoporosis patients

        Exclusion Criteria:

          -  Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids
             or growth hormone within 6 months before trial entry or oral or intravenous systemic
             corticosteroids within 12 months, and any previous use of strontium.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: WheezoMeter® Correlation Study

Eligibility criteria:
Inclusion Criteria:

          -  Patients <= 12 years of age who have wheezing at the time of study as confirmed by the
             physicians' auscultation.

        Control:

          -  Patients <= 12 years of age without history of asthma or other pulmonary conditions,
             and who are without wheezing on physical exam.

        Exclusion Criteria:

          -  Medical problems that would contraindicate Wz% measurement.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 12 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia

Eligibility criteria:
INCLUSION CRITERIA:

        Controls-Group 1:

        Healthy Diagnosis;

        21-80 years;

        No Cigarette Smoking;

        Plasma Cotinine less than 3 ng/mL;

        No olanzapine or risperidone

        Smoker Patients-Group 2:

        Diagnosis of Schizophrenia;

        21-50 years;

        Cigarette Smoking greater than 20 per day and greater than 5 years;

        Plasma Cotinine greater than 100 ng/mL;

        Olanzapine or risperidone greater than 6 mo. and same dose for 2 weeks

        Non-Smoker Patients-Group 3:

        Diagnosis of Schizophrenia;

        21-50 years;

        No Cigarette Smoking;

        Plasma Cotinine less than 3 ng/mL;

        Olanzapine or risperidone greater than 6 mo. and same dose for 2 weeks

        Smoker Controls-Group 4:

        Healthy Diagnosis;

        21-50 years;

        Cigarette Smoking greater than 20 per day and greater than 5 years;

        Plasma Cotinine greater than 100 ng/mL;

        No olanzapine or risperidone

        Non-Smoker Controls-Group 5:

        Healthy Diagnosis;

        21-50 years;

        No Cigarette Smoking;

        Plasma Cotinine less than 3 ng/mL;

        No olanzapine or risperidone
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Efficacy of Fenugreek Supplementation on Men's Health

Eligibility criteria:
Inclusion Criteria:

          -  Healthy men between the ages of 21- 45 that were recreationally active.

        Exclusion Criteria:

          -  Above 30% body composition, not in the age range, history of asthma, diabetes,
             hypoglycemia, or took any hormonal supplements such as testosterone or anabolic
             steroids.
Male
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Allograft Meniscal Arthroplasty for the Treatment of Basal Joint Arthritis of the Thumb

Eligibility criteria:
Inclusion Criteria:

          -  Stage I - III osteoarthritis / traumatic arthritis of the thumb.

        Exclusion Criteria:

          -  Exclusion criteria were diabetes mellitus, kidney insufficiency, OA in the STT joint,
             or malignancy within the past 10 years.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Lactobacillus Reuteri in Children With Constipation

Eligibility criteria:
Inclusion Criteria:

          -  Children 3-7 years old

          -  Occurrence less than three bowel movement per week

          -  Medical history from at least two months]

          -  Ineffective laxative treatment at least two months

          -  The parents approval for child participation in the study and for the treatment

        Exclusion Criteria:

          -  Well-known, organic cause of constipation (i.e. hypothyroidism, Hirschprung disease,
             cystis fibrosis)

          -  Anatomic defects of the alimentary canal

          -  The surgery of the alimentary canal in the past

          -  Treatment of antibiotics/probiotics during last two weeks before start of the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction