Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Circulating Exosomes As Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study")

Eligibility criteria:
Inclusion Criteria:

        Subjects eligible for enrollment must meet all of the following criteria:

          1. Provide signed informed consent. The subject is capable of understanding and complying
             with parameters as outlined in the protocol and able to sign informed consent,
             approved by the Independent Ethic Committee (IEC)/Institutional Review Board (IRB)
             prior to the initiation of any study-specific procedures

          2. Men or women aged >= 18 years.

          3. Eastern Cooperative Oncology Group Performance Status (ECOG) <= 2.

          4. Histologically confirmed adenocarcinoma of the stomach, gastroesophageal junction or
             esophagus.

          5. Metastatic disease or locally advanced disease not amenable to curative surgery.

          6. Radiographically assessable, non-measurable disease or measurable disease as per
             RECIST criteria.

          7. Life expectancy of at least 12 weeks from the time of enrollment.

          8. No other malignancy within the past 5 years except adequately treated basal cell or
             squamous cell skin cancer or carcinoma in situ of the cervix.

          9. No prior chemotherapy for advanced disease.

        Exclusion Criteria:

        Subjects meeting any of the following criteria must not be enrolled in the study:

          1. Gastric carcinoid, sarcomas, or squamous cell cancer.

          2. Pregnant or lactating females.

          3. Significant neurological or psychiatric disorders (psychotic disorders, dementia or
             seizures) that would prohibit the understanding and giving of informed consent.

          4. Active Hepatitis B or C or history of an HIV infection.

          5. Active uncontrolled infection.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones

Eligibility criteria:
Inclusion Criteria:

          -  Women 18-29 years old

          -  Unprotected vaginal or anal sex with at least one man that they perceive as engaging
             in risky behavior OR

          -  Unprotected vaginal or anal sex with more than 1 man regardless of perceived partner
             risk

          -  Can understand written and spoken English

        Exclusion Criteria:

          -  Women younger than 18 years old

          -  Women older than 29 years old

          -  Cannot understand written or spoken English

          -  Previously participated in the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 29 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Physical Performance of Women at Different Stages of the Menstrual Cycle, and Photobiomodulation Therapy

Eligibility criteria:
Inclusion Criteria:

          -  Women

          -  18 to 35 years

          -  Healthy

          -  Physically Active (150 min / week)

        Exclusion Criteria:

          -  Eating disorders;

          -  Hormonal disorders;

          -  Amenorrhea;

          -  Pregnancy;

          -  Polycystic ovary;

          -  Endometriosis;

          -  Tumors;

          -  Musculoskeletal injury in the last 6 months;

          -  Cardiorespiratory disease;

          -  Use of alcohol and illegal drugs during the study.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: A Study of RSLV-132 in Subjects With Primary Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. Meet 4 of 6 criteria of 2002 American-European Consensus Group (AECG) criteria for
             Primary Sjogren's Syndrome

          2. Presence of anti Ro autoantibodies

          3. Presence of interferon signature

        Exclusion Criteria:

          1. Use fo hydroxychloroquine within 30 days of baseline

          2. Use of cyclophosphamide within 180 days of baseline

          3. Use of oral corticosteroids greater than 10 mg/day

          4. Known IgG4-related disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Epithelial Damage in GERD

Eligibility criteria:
Inclusion Criteria:

          -  Typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn
             or acid regurgitation)

          -  abnormal pH-parameters (pathological acid exposure and/or symptom association)

        Exclusion Criteria:

          -  Age <18 years

          -  Previous esophageal or gastric surgery

          -  Severe esophageal motility disorder on manometry

          -  Histological evidence of Barrett's mucosa

          -  Severe co-morbidities (including cardiopulmonary disease, portal hypertension,
             collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a
             gastroscopic procedure)

          -  Use of anticoagulant or immunosuppressive drugs

          -  Inability to stop medication that can influence the test results, like PPI, for at
             least 10 days before tests

          -  Excessive alcohol consumption (>20 units per week)

          -  Patients unable to give informed consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Prevalence and Impact on Quality of Life of Airway Disease in Patients With Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  IPF patients

        Exclusion Criteria:

          -  Patients on systemic steroid

          -  Patients with acute exacerbation within the last 6 months

          -  PFT+BDR, MBPT contra-indication

          -  SpO2 < 90%
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Impact on Energy Intake by Implementing Recommended Food Texture Through Dietary Guidance

Eligibility criteria:
Inclusion Criteria:

          -  Signed consent form

          -  Newly refered patients to FEES examination

          -  Score 1-4 on FEDSS-scale

          -  Consumes 50% energy or more orally

          -  Consumes less energy than calculated energy need (Harris-Benedict)

          -  Individuals of full legal capacity

          -  Individuals above 18 of years

          -  That the patient is capable of executing examinations

        Exclusion Criteria:

          -  Individuals with known eating disorders

          -  Ineligible individuals

          -  Individual in need of translator

          -  Individuals participating in another trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study of Prophylaxis, ACtivity and Effectiveness (SPACE) in Hemophilia Patients Currently Treated With ADVATE or RIXUBIS

Eligibility criteria:
Inclusion Criteria:

          -  13 to 65 years old at the time of screening

          -  has moderately severe or severe hemophilia A or B (FVIII/FIX level

             ≤2%), with or without transient inhibitors

          -  Hemophilia A patient currently prescribed ADVATE (FVIII) or Hemophilia B patient
             currently prescribed RIXUBIS (FIX)

          -  previously treated with plasma-derived FVIII/FIX concentrates or recombinant FVIII/FIX
             for ≥150 documented exposure days (EDs)

          -  is willing and able to comply with the requirements of the protocol

          -  is proficient in the English language to allow for use of the SPACE eDiary

        Exclusion Criteria:

          -  inhibitor titer ≥0.6 Bethesda units or currently being treated for an inhibitor

          -  has participated in another clinical study involving a medicinal product or device
             within 30 days prior to enrollment or is scheduled to participate in another clinical
             study involving a medicinal product or device during the course of this study

          -  is a family member or employee of the investigator

          -  elective major surgery is planned within 6 months after enrollment which may interfere
             with activities of daily living (at investigator's discretion)

          -  continuously require walking assistance devices (eg, wheelchair, crutches, etc.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Physical Therapist as Primary Assessor for Patients With Knee Pain in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  Age >38 years old

          -  Knee pain most of the days the last month

          -  Crepitus on active motion

          -  Morning stiffness, duration less than 30 minutes

          -  The patient has to understand the Swedish language to follow test instructions and to
             complete the self-administered questionnaires.

        Exclusion Criteria:

          -  Already been assessed/diagnosed by a healthcare provider for current knee pain.

          -  knee pain due to a traumatic cause

          -  other rheumatic or systemic diseases

          -  severe somatic or mental disease

          -  pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 38 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: A Longitudinal Study of Hermansky-Pudlak Syndrome Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  Individuals ages 12-90 years with confirmed diagnosis of HPS as defined by
             verification of reduced or absent platelet dense granules by electron microscopy
             and/or genetic diagnosis

          -  Ability to provide informed consent, or consent of parent/guardian and assent for
             minors

        Exclusion Criteria:

          -  Status-post lung transplantation

          -  Perceived unsuitability for participation in the study in the opinion of the
             investigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction