Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Miromatrix Biological Mesh for Hiatal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  between 18 and 80 years old on the day of study enrollment

          -  able and willing to sign the consent form and comply with all study visits and
             procedures

          -  able to undergo elective laparoscopic hiatal hernia repair

          -  free of cognitive or speech impairment

          -  documented, symptomatic type II or III hernia ≥5cm in the axial/vertical dimension

          -  commit to non-smoking for at least 4 weeks prior to procedure

        Exclusion Criteria:

          -  previous operation of the esophagus or stomach

          -  sensitivity to porcine material

          -  pregnant or plan to be pregnant within next 2 years

          -  immunocompromised or at risk of immunosuppression (i.e. be HIV positive, be
             experiencing organ rejection, be a recent or anticipated chemotherapy recipient) as
             determined by the Investigator

          -  require emergent operation for acute gastric volvulus or strangulation

          -  American Society of Anesthesiology (ASA) class 4 or greater

          -  BMI ≥40

          -  life expectancy of less than 2 years at the time of enrollment

          -  associated gastrointestinal disease that requires extensive medical or surgical
             intervention that might interfere with the quality of life assessment (e.g. Crohn's
             disease)

          -  any condition in the opinion of the Investigator that would preclude the use of the
             study device, or preclude the subject from completing the follow-up requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Phase 2 Dose-finding Study to Evaluate the Effects of BA058 in the Treatment of Postmenopausal Women With Osteoporosis

Eligibility criteria:
Primary Inclusion Criteria:

          -  The patient has a bone mineral density T-score ≤ 2.5 at the lumbar spine or hip
             (femoral neck) by dual energy x-ray absorptiometry (DXA). Women with a bone mineral
             density T-score of 2.0 or lower and a prior low-trauma forearm, humerus, vertebral,
             sacral, pelvic, hip, femoral, or tibial fracture within the past 5 years, or who have
             an additional risk factor such as age 65 or greater or a strong maternal history of
             osteoporosis defined as a fracture related to osteoporosis or osteoporosis itself as
             determined by BMD criteria, are also study candidates.

          -  The patient is in good general health as determined by medical history and physical
             examination and is without evidence of clinically significant abnormality in the
             opinion of the Investigator.

        Primary Exclusion Criteria:

          -  History of bone disorders (e.g., Paget's disease) other than postmenopausal
             osteoporosis.

          -  Prior treatment with approved or as yet unapproved bone-acting investigational agents.

          -  History of carcinoma, nephrolithiasis or urolithiasis within the past five years or
             osteosarcoma at any time.

          -  History of radiotherapy (radiation therapy).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: The Effects of Omega-3 Fatty Acid (OMACOR) on the Low-density Lipoprotein (LDL) Sub-fraction in Type 2 Diabetic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Agreed for informed consent

          -  Age between 40-70 years old

          -  Type 2 diabetes mellitus

          -  Combined hyperlipidemia

          -  Serum triglyceride level between 200-500(mg/dl)

          -  No sudden change of glucose lowering therapies during trial, anticipated

        Exclusion Criteria:

          -  Hypersensitivity to OMACOR(Omega-3 fatty acid)

          -  Alcoholics

          -  Pregnancy

          -  Proliferative diabetic retinopathy

          -  Patients already taking fibrates

          -  Enrolled in other clinical trials during the recent 3 months

          -  Severe ischemic heart disease, liver disease, neurological disease

          -  AST/ALT level 2 folds above the normal reference level

          -  Psychiatric disorder not adequately controlled

          -  Serum creatinine over 2.0 (mg/dl)

          -  Previous pancreatic surgery

          -  Patients who can not maintain regular diet
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Anomalies of Dense Platelet Granules

Eligibility criteria:
Inclusion Criteria:

          -  Adult or child patient ≥ 2 years

          -  Having a hemorrhagic score ISTH > 3 for men, > 5 for women and > 2 for children.

          -  With no abnormal coagulation (defined by normal TP and TCK or activity ≥ 50% of FII,
             FV, FVII, FX, FVIII, FIX, FXI)

          -  no deficiency of Willebrand factor (defined by a cofactor activity with Ristoctin
             (VWF: RCo < 50%))

          -  no a known major thrombocytopenia/thrombopathy linked to a deficiency of one of the
             major platelet receptors

          -  Information of the patient and/or his legal representative present

        Exclusion Criteria:

          -  Inability or refusal of compliance with research requirements

          -  Thrombocytopenia < 100 G/L

          -  Treatments interfering with platelet functions within 10 days prior to inclusion

          -  Malignant hemopathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Studies of Children With Metabolic and Other Genetic Disorders

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Patients with suspected or diagnosed genetic and/or metabolic conditions of all ages
             are eligible for this protocol.

          -  In addition, children with unexplained developmental delay, deafness, dysmorphism,
             congenital malformations, acidosis, failure to thrive, feeding problems, short
             stature, birth defects, and other syndromes of sporadic or unknown etiology will
             qualify for this protocol.

          -  The actual selection of patients most appropriate for research and clinical training
             needs will be made by protocol investigators.

        EXCLUSION CRITERIA:

          -  Patients that their care requires resources not available at the NIH Clinical Center
             will not be eligible for the in-patient part of this study.

          -  There are no exclusions for the out-patient or DNA collection part of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Menstrual Cycle Characteristics of Healthcare Professionals

Eligibility criteria:
Inclusion Criteria:

          -  Working at Covid 19 Pandemic Hospital

          -  Being at between 18 and 47 years old

          -  Having menstruation

        Exclusion Criteria:

          -  Oral contraceptive users

          -  Pregnants

          -  Having malignancy

          -  Having primary amenorrhea

          -  Being at menopause

          -  Lactation
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 47 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Clinical Evaluator Outcomes Reliability Study

Eligibility criteria:
Dystrophinopathy Participant Inclusion Criteria:

          -  Site confirmed genetic diagnosis of a dystrophinopathy

          -  Aged 6 years and older

          -  Able to transfer to testing table

          -  Able to walk 10 meters without an assistive device

        Dystrophinopathy Participant Exclusion Criteria:

          -  Investigator assessment of inability to comply with protocol assessments

          -  Participants who have attention deficient disorder or other cognitive conditions that
             may limit attention span to perform protocol assessments
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Comparison of Postoperative Pain After Gallbladder Retrieval From Umbilical and Epigastric Ports.

Eligibility criteria:
Inclusion Criteria:

          -  All healthy patients without cholecystitis

        Exclusion Criteria:

          -  Acute cholecystits, mucocoele, empyema, carcinoma, peritonitis, ASA 3 and 4
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effect and Essentiality of Vertebroplasty Surgery in Acute Vertebral Compression Fractures

Eligibility criteria:
Inclusion Criteria:

          -  vertebral compression fracture on spine radiograph (minimum 15% height loss)

          -  level of fracture at Th5 or lower; back pain for 6 weeks or less

          -  focal tenderness at fracture level on physical examination

          -  bone oedema of vertebral fracture on MRI

          -  decreased bone density (T scores ≤-1)

        Exclusion Criteria:

          -  severe cardiopulmonary comorbidity

          -  suspected underlying malignant disease

          -  radicular syndrome

          -  spinal-cord compression syndrome

          -  contraindication for radiography exam
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Development of a Nutrigenetic Test for Personalized Prescription of Body Weight Loss Diets (Obekit)

Eligibility criteria:
Inclusion Criteria:

          -  Body Mass Index (BMI) between 25 and 40 kg/m2

          -  Physical examination and vital signs normal, or is considered abnormal, but clinically
             insignificant by researcher.

          -  In the case of individuals with chronic stable dose drug treatment and during the last
             3 previous months at baseline, the investigator will assess their possible inclusion.

        Exclusion Criteria:

          -  BMI less than 25 or higher than 40 kg/m2

          -  Pregnant women

          -  Breastfeeding period. If artificial feeding until 6 months after birth.

          -  Type 1 diabetes

          -  Severe kidney diseases

          -  Severe digestive system diseases

          -  Electrolyte disorders (disorders of sodium, potassium, calcium, chlorine, phosphorus,
             magnesium)

          -  Acute cardiovascular diseases

          -  Cancer

          -  Anemia

          -  Eating disorders

          -  Recent prescription drug treatment (without stable doses scheduled)

          -  Drug therapy that can influence weight loss as corticosteroids.

          -  Some type of cognitive impairment and / psychic

          -  Subjects in which poor collaboration or, in the investigator's opinion, have
             difficulty following the procedures of the study is foreseen

          -  Lack of commitment (at the discretion of the investigator) with the intervention,
             suspected non-compliance, or real difficulties to follow the development of the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment