Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient's own account: I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Clinical trial: Diagnostic Accuracy of Whole Body Magnetic Resonance Imaging in Inflammatory Myopathies

Eligibility criteria:
Inclusion Criteria:

          -  Skin rash typical of dermatomyositis: "lilac" rash (+/- oedemata) of upper eyelids,
             periungual sign, erythematous-scaly eruption occurring over the MCP and IPP, elbow,
             knees (Gottron's signs ands papules), erythema of light-sensitive areas OR

          -  Muscle weakness which is proximal, bilateral and objectifiable by clinical examination
             ≤ 4/5, and CPK≥2N (N<170).

          -  Increase CPK and presence of acquired myositis specific antibody

        AND

        -Onset of troubles ≤3 years

        Exclusion Criteria:

          -  Pregnant female

          -  Proximal motive neuropathy

          -  Refusing participation

          -  Patient under 18 years old

          -  Adult patient under legal protection

          -  Patient with contraindication for MRI, pacemaker

          -  For all other magnetic or ironic implanted equipments, metal workers, must contact PI
             to ensure their eligibility

          -  Ocular muscles weakness, isolated dysarthria,

          -  Patients suffering from toxic myopathy, amyloidosis, inherited muscular dystrophy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Maternal Transcriptomic Regulation of the Preimplantation Embryo

Eligibility criteria:
Inclusion Criteria:

          -  Women with age comprised between 18 and 45 years

          -  Normal uterus (evaluated trough ultrasound 2D/3D and/or hysteroscopy)

          -  Presence of at least one ovary

          -  Body mass index:

          -  Normoweight: 18.0-24.9 kg/m2 and non smokers

          -  Obese ≥30.0 kg/m2 and non smokers

          -  Smokers: Normoweight and smoke at least 10 cigarettes per day

        Exclusion Criteria:

          -  Overweight=25.0-29.9 kg/m2

          -  Patients with Intrauterine device in the last 3 months

          -  Patients who had had hormonal contraceptives in the 2 previous months.

          -  Adnexal or uterine pathologies

          -  Polycystic ovary

          -  Existence of serious or uncontrolled bacterial, fungal or viral infections that could
             interfere with the involvement of the patient in the study or in the evaluation of the
             study results.

          -  Any disease or medical condition that could be unstable or could endanger the security
             of the patient and her compliance in the study.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Lymphocyte Sub-populations and Auto Immune Diseases

Eligibility criteria:
Inclusion Criteria:

          -  autoimmune or infectious disease

        Exclusion Criteria:

          -  No
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Vitamin D Status on Clinical Pregnancy Rates Following Intra Cytoplasmic Sperm Injection

Eligibility criteria:
Inclusion Criteria:

          -  Age between 20 and 35 years old.

          -  Body mass index between 20 - 30.

          -  Unexplained infertility .

          -  Follicle-stimulating hormone level 12 IU/L or lower (baseline level, cycle day 3).

          -  Normal hysteroscopy ( healthy uterus with no fibroids or other growths)

          -  Fresh embryo transfer of 2 or more blastocysts stage.

          -  Embryo transfer on day 5 after fertilization

        Exclusion Criteria:

          -  Women younger than 20 years old or older than 35 years old.

          -  Previous one or more failed IVF.

          -  Uncorrected congenital or acquired uterine anomalies.

          -  Other causes of infertility rather than unexplained infertility.

          -  Less than 2 embryo transfer, cleavage stager frozen embryo transfer.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Symptom-Based Markers for COVID-19 Transmission

Eligibility criteria:
Inclusion Criteria:

          -  Fluent in English

          -  Tested positive for COVID-19

        Exclusion Criteria:

          -  Prisoners

          -  Unable to provide own informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Efficacy and Safety of Odanacatib (MK-0822) in Participants With Involutional Osteoporosis (MK-0822-022)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal woman (for at least 5 years) or men who are aged between 45 to 85

          -  Participant who has low bone mineral density

          -  Participant has anatomy suitable for dual-energy x-ray absorptiometry (DXA) of the
             lumber spine and hip

          -  Participant is ambulatory (can walk)

        Exclusion Criteria:

          -  Participant has secondary osteoporosis or has a metabolic bone disorder other than
             osteoporosis or osteopenia

          -  Participant has received osteoporosis medications or other medications that affect
             bone

          -  Participant is already participating in another drug study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: The Effect of Information on Physical Fitness Measures and Training in Overweight Children

Eligibility criteria:
Inclusion Criteria:

          -  Pre pubertal children

          -  Study group: BMI precentiles over 85 (overweight and obese children)

          -  Control group: BMI precentiles between 5-85 (normal weight children)

        Exclusion Criteria:

          -  Children with organic Disease

          -  Competitive athlete
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 13 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effect of Mobilization With Movement on Pain and Function Among Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Had unilateral or bilateral knee OA

          -  Knee OA K&L grade ≥ 2

          -  VAS = 3 cm over the previous 24 hours

          -  Able to walk ≥ 6-meter distances with or without an aid

        Exclusion Criteria:

          -  Had knee or lower limb surgery

          -  Oral corticosteroid use (current\ 4 weeks)

          -  Altered sensation around knee and shoulder

          -  Exhibited cognitive difficulties

          -  Intra-articular corticosteroid or hyaluronic acid injection within 6 months

          -  Had leg sciatica

          -  Contraindication to manual therapy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Evaluate SAGE-547 in Patients With Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Males and females, 35-75 years old with a diagnosis of essential tremor with symptoms
             clearly present in at least 1 upper limb; patient has had tremor present for at least
             2 years prior to Screening

          -  Off medication, or on a stable dose of medication for their tremor for at least 28
             days prior to Screening

        Exclusion Criteria:

          -  Recent history or active clinically significant manifestations of metabolic, hepatic,
             renal, hematological, pulmonary, cardiovascular, gastrointestinal, musculoskeletal,
             dermatological, urogenital, eyes, ears, nose, or throat, psychiatric, or neurological
             (other than essential tremor) disorders

          -  Medical history of seizures
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Evaluation of Academic and Professional Trajectories of Narcoleptic Patients

Eligibility criteria:
Inclusion Criteria:

        Group "Narcoleptic Patients":

          -  Type 1 or Type 2 narcolepsy

          -  > 18 years

          -  Usually followed at the Lyon Sleep Medicine Center

        Group "Control":

          -  At least one member of each family of cases (siblings, cousins ...)

          -  > 18 years and of the same age as the case if possible (+/- 5 years)

          -  No narcolepsy

        Exclusion Criteria:

          -  uncertain diagnosis (for the "Narcoleptic Patients" Group)

          -  poor knowledge of the French language

          -  Refusal to participate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain most of the days the last month

          -  Over 38 years old

          -  Crepitus on active motion

          -  Morning stiffness less than 30 minutes

        Exclusion Criteria:

          -  Not been diagnosed for current knee pain

          -  Non-traumatic cause due to current knee pain

          -  No other rheumatic, severe somatic or psychological diseases that can affect the
             outcome measures.

          -  Not pregnant

          -  Does not know enough Swedish to answer questionnaires.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 38 Years old.


Eligibility (NLI label): Entailment