Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Heart Rate Variability in Duchenne Muscular Dystrophy During Computer Task

Eligibility criteria:
Inclusion Criteria:

          -  DMD diagnoses was based on molecular methods and/or muscular protein expression.

          -  TD age-matched with DMD.

        Exclusion Criteria:

          -  subjects with severely dilated myocardium.

          -  subjects with other associated diseases.

          -  individuals with inability to understand task instructions.
Male
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Study to Evaluate the Safety and Efficacy of a Once-Daily CLS001 Topical Gel Versus Vehicle

Eligibility criteria:
Inclusion Criteria:

          1. Healthy, male and non-pregnant female subjects, 18 years of age or older.

          2. A diagnosis of papulopustular rosacea with ≥30 inflammatory facial lesions at
             Baseline. Subjects must have no more than 2 nodular lesions, at Baseline.

          3. Subjects with the presence of telangiectasia at Baseline.

          4. Subjects with an erythema score of at least 2 on the Investigator Assessment of
             Erythema scale at Baseline.

          5. Subjects with severe rosacea on the Investigators Global Assessment scale at Baseline.

        Exclusion Criteria:

          1. Subjects with steroid rosacea or subtype 3 (phymatous rosacea).

          2. Subjects with nodular rosacea.

          3. Standard exclusion criteria.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Effectiveness of Video Based Games on Upper Extremity Functions in Mild Mental Retardation Diagnosed Cases

Eligibility criteria:
Inclusion Criteria:

          -  He / she has been diagnosed with mild mental retardation Being between 5 and 18 years
             of age Ability to adapt to exercises No epileptic epilepsy no cardiac or orthopedic
             disturbance

        Exclusion Criteria:

          -  Being healthy Not be between 5-18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Subject is a male or a female aged ≥ 18 years

          -  Have given their written consent to participate in the study

          -  Use of artificial tears (AT), autologous serum or specific dry eye medications during
             the last 6 months prior to the selection

          -  Willing to not use AT or autologous serum for the study duration

          -  VAS scale for Dry Eye Symptom Score ≥ 40

          -  Total CFS ≥ 5

          -  Schirmer's test with anesthesia < 10 mm/5min

          -  Patients with Sjögren Syndrome

        Exclusion Criteria:

          -  Any concomitant treatment or prior ocular procedure or surgery, or alteration of the
             dose of systemic medications at the time of entry into the study

          -  Use of contact lenses during the study

          -  Significant Eye diseases according to investigator's opinion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: INdividualized ITI Based on Fviii(ATE) Protection by VWF

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of congenital Hemophilia A and baseline FVIII ≤2%.

          2. Weight ≥ 5 kg

          3. History of FVIII inhibitor titer ≥5 BU

          4. Current FVIII inhibitor titer ≥5 BU or ≥0.6 BU and failed ITI defined by FVIII
             recovery <66% normal and half-life <6 hours

          5. Adequate venous access for daily concentrate infusions

          6. For participants <18 years, a parent or guardian willing and able to provide informed
             consent with verbal or written assent from the child if require by the local
             institution. For participants ≥18 years, a willingness and ability to provide informed
             consent from the subject.

          7. Ability to comply with study related treatments, evaluations, and follow-up.

        Exclusion Criteria:

          1. Acquired hemophilia

          2. Congenital or acquired bleeding disorder in addition to Hemophilia A

          3. ITI factor replacement regimen within the past one month unless there is clear
             evidence of ITI failure with no reduction in inhibitor titer over the past two months

          4. HIV positive with viral load ≥200 particles/μL or ≥400,000 copies/mL

          5. Rituximab within the past 3 months

          6. IVIG within the past 1 month

          7. Treatment with other immunosuppressive drugs within the past 1 month (excluding
             intermittent steroid use for asthma)

          8. Concomitant experimental treatment

          9. History of hypersensitivity to plasma-derived VWF- or FVIII-containing concentrates

         10. Elective surgery planned in the next 6 months (excluding vascular access procedure)

         11. Any condition or chronic illness, which in the opinion of the investigator makes
             participation ill-advised

         12. Inability or unwillingness to complete required screening, follow-up, and exit studies
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Effect of Administration of the Combination Bezafibrate More Berberine on Lipid Profile in Patients With Dyslipidemia

Eligibility criteria:
Inclusion Criteria:

        A. Men and women B. Accomplished age 30 to 60 years

        C. Diagnosis of mixed dyslipidemia established to meet the following criteria:

          -  Total cholesterol> 200 mg / dL

          -  Triglycerides> 150 mg / dL 27 D. BMI of 25 kg / m2 to 39.9 kg / m2, weight stable over
             the past three months, defined as a variability in the lower body weight of 5%.

        E. No drug treatment for lipid profile 3 months prior to baseline. F. Women must ensure a
        non-hormonal method to avoid pregnancy during the study period G. written information
        consent

        Exclusion Criteria:

        A. Removal for informed consent letter B. Loss of monitoring C. Presence of serious adverse
        event D. Adherence to treatment <80% E. Consumption of drugs known about lipid profile,
        glucose metabolism, blood pressure and body weight during the intervention period influence
        F. Intolerance or not tolerability or hypersensitivity to the compounds used in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Arthroscopic Diagnosis and Treatment of Dorsal Wrist Syndrome in Patients With Synovial Hypertrophy

Eligibility criteria:
Inclusion Criteria:

          1. Men or women

          2. Age 18-65 years old, both included

          3. Diagnose of primary dorsal wrist syndrome, defined as:

             3.1 Radiocarpal dorsal focal pain 3.2 Pain increases in hyperextension of the wrist
             and in axial load 3.3 X-rays and MRI without significant findings 3.4 Watson test,
             extension finger test, Kleinman shuck test, distal radio-ulnar ballottement test,
             fovea sign all of them negatives and absence of tenosynovitis of the extensor tendons.

          4. Refractory to conservative treatment consisting in at least 3 months of physical
             therapy.

          5. Presence of a hypertrophy of the dorsal synovial of the wrist diagnosed through direct
             visualization in wrist arthroscopy.

          6. Other diagnoses excluded through wrist arthroscopy

        Exclusion Criteria:

          1. Hand or wrist fractures

          2. Arthritis

          3. Carpal boss

          4. Scapho-lunate ligament tears

          5. Luno-triquetral ligament tears

          6. Triangular fibrocartilage tears

          7. Bone necrosis

          8. Systemic arthritis as rheumatoid arthritis, psoriasic arthritis, gouty arthritis,
             etc.)

          9. Dorsal or volar ganglions

         10. Distal radio-ulnar joint injury or instability

         11. Hand or wrist infections or tumors
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis

Eligibility criteria:
Inclusion Criteria:

          -  patients over 18 year old

          -  patients with an acute arthritis defined by an evolution of less than 6 weeks

          -  patients benefiting from joint fluid puncture for diagnostic purposes in the
             rheumatology hospitals participating in the study

          -  patients who received information about the protocol and have not expressed opposition
             to participate

        Exclusion Criteria:

          -  patients opposing the study

          -  protected major (safeguard justice, trusteeship and guardianship) and persons deprived
             of liberty
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Syncope: Pacing or Recording in the Later Years

Eligibility criteria:
Inclusion Criteria:

        -Patients are eligible if they have:

          -  >1 syncopal spell within 1 year preceding enrollment, and

          -  bifascicular block on a 12-lead ECG, and

          -  Age > 50 years and

          -  written informed consent. Syncope will be defined based on history using a
             standardized form.

        Exclusion Criteria:

        -Patients will be excluded if they have criteria related to study strategies, including:

          1. previous pacemaker, ICD, or Implantable Loop Recorder in situ,

          2. ACC/AHA/HRS Class I indication for permanent pacing or ICD implantation,

          3. left ventricular ejection fraction < 35% mandating ICD therapy,

          4. contra-indication to a transvenous pacemaker such as artificial tricuspid valve or
             active sepsis.

             -Patients will also be excluded if a potential competing cause of syncope poses a
             threat to life, such as:

          5. hypertrophic cardiomyopathy,

          6. documented sustained ventricular tachycardia or

          7. inducible, sustained monomorphic ventricular tachycardia on EP study.

             -They will be excluded if they have:

          8. a history of myocardial infarction within 3 months prior to enrollment, and

          9. a major chronic co-morbid medical condition that would preclude 24 months of
             follow-up.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction