Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Safety and Pharmacokinetics of Subcutaneous Injection of OCTA101 in Adult Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Severe hemophilia A (<1% FVIII:C) as documented in medical records

          2. Males ≥18 years of age

          3. Subjects who have had ≥150 exposure days (EDs) with a FVIII product

          4. Written informed consent for study participation obtained before undergoing any study
             specific procedures

        Exclusion Criteria:

          1. Previous participation in this trial

          2. Use of an Investigational Medicinal Product within 30 days prior to the first OCTA101
             injection

          3. History of FVIII inhibitors titre ≥0.6 BU/mL defined by medical records

          4. Inhibitors to FVIII (≥0.6 BU/mL) at screening measured by Nijmegen modified Bethesda
             method at central laboratory

          5. Human immunodeficiency virus (HIV) positive subjects with a CD4+ count <200/mL

          6. Clinically significant anemia at screening (hemoglobin <8 g/dL)

          7. Presence of any significant comorbidity (at the discretion of the investigator) that
             might confound the interpretation of the study data and/or that might put the patient
             at undue risk by participating in the trial

          8. Any coagulation disorder other than hemophilia A

          9. AST or ALT levels >3 times the upper limit of normal

         10. Creatinine >120 μmol/L

         11. Platelet count <100,000 μL

         12. BMI ≥30 kg/m²
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Single Escalating Dose and Multiple Dose Study of BAY 1093884 in Subjects With Severe Hemophilia Types A or B, With or Without Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Males with severe congenital Hemophilia A or B defined as <1% FVIII or Factor IX (FIX)
             concentration by measurement at the time of screening or from reliable prior
             documentation

          -  For subjects in Cohorts I-IV, I-SC1 and I-SC2; If history of inhibitors is evident,
             inhibitor titer of ≥5 Bethesda Units (BU) at screening or prior to screening at any
             time from medical records.

          -  Age: 18 to 65 years of age at screening

          -  Body mass index (BMI): 18 to 29.9 kg/m²

        Exclusion Criteria:

          -  Subjects with known bleeding disorders (such as von Willebrand factor [vWF]
             deficiency, FXI deficiency, platelet disorders, or known acquired or inherited
             thrombophilia etc.) other than congenital Hemophilia A or B with or without inhibitors

          -  History of angina pectoris or treatment for angina pectoris

          -  History of coronary and/or peripheral atherosclerotic disease, congestive heart
             failure, disseminated intravascular coagulopathy, or stage 2 hypertension defined as
             systolic blood pressure (SBP) ≥160 mmHg or diastolic blood pressure (DBP) ≥100 mmHg
             even if controlled

          -  History of thrombophlebitis, venous / arterial thromboembolic diseases (particularly
             deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction,
             cerebrovascular accident, ischemic heart disease, transient ischemic attack)

          -  Known or suspected hypersensitivity of the immune system, history of anaphylactic
             reaction, known (clinically relevant) allergies, non-allergic drug reactions, or
             multiple drug allergies
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Body Weight Assessment in Swiss Primary School Children: Trend Analysis Over 10 Years

Eligibility criteria:
Inclusion Criteria:

          -  age 6-12 years

          -  child is attending one of the selected classrooms

        Exclusion Criteria:

          -  age below 6 or above 12 years
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Effect of Smoking Exposure on Smoking Relapse Following Brief Abstinence - 2

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of nicotine dependence with psychological dependence

          -  Smokes at least 15 cigarettes per day for the three months prior to enrollment

          -  Currently not seeking treatment for nicotine dependence

          -  Medically healthy, on the basis of physical examination and medical history, vital
             signs, EKG, and laboratory tests

          -  Females must use an effective method of contraception for the duration of the study

        Exclusion Criteria:

          -  Diagnosis of abuse or dependence on alcohol or drugs other than nicotine

          -  Current Axis I diagnosis or current treatment with psychotropic medications within the
             3 months prior to enrollment

          -  History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety
             disorders

          -  Currently seeking treatment for nicotine disorders

          -  On parole or probation

          -  History of seizures or head trauma with loss of consciousness, brain contusion, or
             fracture

          -  History of significant recent violent behavior

          -  Blood pressure greater than 150/90

          -  History of eating disorders

          -  Pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Ultrasound and Videofluoroscopy for Diagnosing Swallowing Disorders

Eligibility criteria:
INCLUSION CRITERIA:

        Any Clinical Center inpatients and outpatients with known or suspected dysphagia on any
        other NIH institute protocol can be included for study as well as patients who are admitted
        specifically for this protocol.

        Those patients at risk for oropharyngeal dysfunction will be screened initially by
        completing a self-assessment swallowing questionnaire, and by an interview with staff
        and/or family members. Patients who demonstrate appropriate signs and symptoms of dysphagia
        and oral motor impairment on the screening assessment will be considered for the protocol:

        Difficulty swallowing food or pills.

        Changed swallowing ability.

        Coughing or choking when eating.

        Shortness of breath during swallowing.

        Food backing up into the mouth or nasal passage.

        Fever or voice changes after swallowing.

        Pain when swallowing.

        Unexplained loss of weight.

        EXCLUSION CRITERIA:

        Patients who are severely demented or severely compromised will be excluded if they do not
        have sufficient cognitive ability to follow directions.

        Patients who are non-ambulatory will be excluded if they can not be braced or supported
        within the fluoroscopy unit.

        Highly agitated individuals will also be excluded if they are unable to remain confined in
        the equipment.

        Infants and children under age 3 will be excluded due to radiation risk on the developing
        visual system.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Nitroglycerin Ointment for Preventing Bone Loss in Postmenopausal Women

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal for a minimum of 13 months

          -  Lumbar spine T-score of 0 to -2.5 (0 to -2.0 if over 60 years old) by Dual Energy
             X-ray Absorptiometry (DEXA) (i.e., evidence of normal bone mass or osteopenia)

          -  Body Mass Index (BMI) between 18 and 32

          -  Planning to live in the greater New Brunswick, NJ, area for at least 3 years

        Exclusion Criteria:

          -  Radiographically or DEXA-morphometrically proven vertebral or hip fracture

          -  Conditions requiring routine use of sublingual, transdermal, or oral nitrates

          -  Significant postmenopausal symptoms that require estrogen therapy

          -  Metabolic bone diseases other than postmenopausal bone loss (e.g., active
             hyperthyroidism, hyperparathyroidism, Paget's disease of bone, etc.)

          -  Insulin-dependent diabetes mellitus

          -  Significant migraine headaches

          -  History of renal calculi

          -  Cancer within 5 years prior to study entry

          -  Any condition causing an anticipated life expectancy of less than 3 years

          -  Failure to maintain 75% to 125% compliance with open-label calcium with vitamin D
             regimen during the screening period
Female
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Osteoporosis Coordinator for Low Volume Community Hospitals

Eligibility criteria:
Inclusion Criteria:

          1. Cluster site (hospital) level: Hospitals with no dedicated osteoporosis coordinator
             that treat more than 60 patients/year in their Emergency Department and who have a
             Telehealth studio.

          2. Patient level: Patients 40 years old and over (men and women) presenting with a low
             trauma fracture of the hip, forearm and wrist, rib(s), sternum, thoracic and lumbar
             spine, shoulder and upper arm, pelvis, lower leg and ankle. Subjects without previous
             medication as well as subjects on osteoporosis medication and presenting with a
             fracture will be included.

        Exclusion Criteria:

          1. Hospitals that have an Osteoporosis Strategy fracture clinic coordinator

          2. Fractures associated with major trauma; fractures due to malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery Biopsy

Eligibility criteria:
Inclusion Criteria:

          -  positive artery biopsy between january 1st 2000 and july 25th 2019

        Exclusion Criteria:

          -  orther vascular biopsy than temporal artery biospy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease

Eligibility criteria:
Mild to moderate Alzheimer's disease. Ability to cooperate with MRI scanning and
        neuropsychological testing. Live at home or in the community and a caregiver capable of
        accompanying the patient on all clinic visits and visiting the patient at least 5 times per
        week.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment