Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Adult male subject aged 18 to 65 years inclusive

          -  BMI > 30 kg/m2 and < 50 kg/m2

          -  Serum total testosterone concentration below the normal range

          -  LH levels below the upper limit of normal

          -  Oestradiol levels within or above the normal range of approved assay

          -  At least two symptoms of androgen deficiency present for at least 2 months prior to
             the first Screening Visit, with at least one of these being a sexual dysfunction

        Exclusion Criteria:

          -  Evidence of clinically significant endocrinopathy at screening that may interfere with
             the study assessments

          -  Other types of hypogonadotropic hypogonadism or primary hypogonadism

          -  Any other pituitary or hypothalamic disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Emergency Department Crowding in Relation to In-hospital Adverse Medical Events

Eligibility criteria:
Inclusion Criteria:

          -  All adult (18 years or older) patients presenting to the ED

          -  All adult (18 years or older) patients transferred from the ward to ED for upgrading
             of care

        Exclusion Criteria:

          -  All patients who died on arrival in the ED

          -  Patients transferred from another acute care facility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercise With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Being diagnosed with knee osteoarthritis

          -  To be in the age range of 40-70

          -  No lower extremity surgery in the last 6 months.

          -  Agree to participate in the study

        Exclusion Criteria:

          -  Having had hip-knee replacement surgery

          -  Surgery planned in the last 6 months

          -  Having received physical therapy in the last 6 months

          -  Having uncontrollable hypertension and cardiac problems

          -  Having been diagnosed with rheumatoid arthritis
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss

Eligibility criteria:
Inclusion Criteria:

          1. History of 2 or more unexplained recurrent miscarriage.

          2. Child bearing period (18-35 years old).

          3. Non pregnant state.

          4. Regular menstrual cycles for the previous three months before the study.

          5. No hormonal contraception or intrauterine device.

          6. impaired uterine artery blood flow (PI >2.02) (Mansour et al., 2018).

        Exclusion Criteria:

          -  1-Having any possible causes of abortion: anatomical, genetic, endocrinological,
             infectious, or immunological.

             2- Autoimmune disorders which may affect blood vessels and their blood flow (systemic
             lupus).

             3- Systemic disease that might affect the hemodynamic indices (e.g. thrombocytopenia,
             thyrotoxicosis … etc.).

             4- Diagnosed or treated thrombophilia. 5- Any vascular disease (e.g. coronary artery
             disease). 6- History of oophorectomy. 7- History of consanguinity. 8- Family history
             of chromosomal abnormalities (e.g. trisomy 21, trisomy 13… etc.).
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men

Eligibility criteria:
-  Healthy Men Ages 18-80

          -  All ethnicities eligible

          -  Men with indeterminate erectile dysfunction eligible with normal serum gonadotropin,
             total testosterone, prolactin and TSH concentrations and documented integrity of the
             neurovascular, cardiovascular, hepatorenal systems
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study Evaluating The Efficacy And Safety Of Xyntha In Children Less Than 6 Years Of Age

Eligibility criteria:
Inclusion Criteria:

          -  Male patients less than 6 years of age with moderately severe to severe hemophilia A
             (FVIII less than or equal to 2%).

          -  Treatment history of less than 50 exposure days to prior recombinant or plasma-derived
             FVIII replacement products.

          -  Not receiving treatment for HIV or hepatitis infection, or the patient is on a stable
             antiviral regimen at the time of enrollment in the study.

        Exclusion Criteria:

          -  Presence of any bleeding disorder in addition to hemophilia A.

          -  Inhibitor titer of greater than or equal to 5 Bethesda Units (BU) at screening.

          -  Treated with immunomodulatory therapy during the screening period

          -  Treatment history of more than 5 exposure days (ED) to Xyntha.

          -  Known hypersensitivity to hamster protein.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 5 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Rational Approach to a Unilateral Pleural Effusion2

Eligibility criteria:
Inclusion Criteria:

          1. Patients with recurrent pleural effusion of unknown origin after a first pleural tap
             according to BTS guidelines.

          2. Indication for thoracoscopy according to BTS guidelines.

          3. Patients accept further investigation according to Danish and BTS guidelines.

          4. Have received oral and written consent and agreed.

          5. At the time of inclusion, above 18 years of age.

        Exclusion Criteria:

          1. Female patients: pregnancy or breastfeeding.

          2. Lack of language comprehension.

          3. Legally incompetent patients.

          4. Life expectancy less than 3 month.

          5. Contraindications to pleural tissue sampling.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Internet-based Self-help Program for Vestibular Rehabilitation in Chronic Dizziness

Eligibility criteria:
Inclusion Criteria:

          -  Satisfy diagnostic criteria for persistent positional perceptual dizziness (PPPS) or
             satisfy criteria with a duration of <3 months

          -  Vertigo symptom scale (VSS-SF) >12

        Exclusion Criteria:

          -  Cognitive dysfunction that is so pronounced that it will make participation difficult

          -  Unable to read, understand Norwegian

          -  Severe medical or psychiatric illness (including substance abuse) that reduces the
             patient's ability to follow the VR program
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: TElemedicine for NARcolepsy

Eligibility criteria:
Inclusion Criteria:

        • Adolescents (≥14 years old) and adults with a diagnosis of narcolepsy according to ICSD-3
        criteria at their first ("incident") or with established diagnosis ("prevalent" subjects),
        able to provide consent

        Exclusion Criteria:

          -  inability to read, write, or using a tablet;

          -  major psychiatric disorders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.


Eligibility (NLI label): Entailment