Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Study to Evaluate CORT125134 in Participants With Cushing's Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. Has a confirmed diagnosis of endogenous Cushing's syndrome.

          2. Requires medical treatment of hypercortisolemia.

          3. Meets at least one of the following criteria:

               1. Has type 2 diabetes mellitus.

               2. Has impaired glucose tolerance.

               3. Has hypertension.

        Exclusion Criteria:

          1. Has non-endogenous source of hypercortisolemia

          2. Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism

          3. Has poorly controlled hypertension

          4. Has Stage ≥ 4 renal failure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Trial of L-DOPA as a Treatment to Improve Vision in Albinism

Eligibility criteria:
Inclusion Criteria:

          -  Age 3 to 60 years with albinism

        Exclusion Criteria:

          -  Glaucoma or at increased risk of glaucoma

          -  History of dystonia

          -  History of melanoma

          -  Planning to undergo eye muscle surgery during study time frame

          -  Undergoing vision therapy

          -  Taking iron supplements or vitamins with iron

          -  Taking medication for ADHD

          -  Known liver or gastrointestinal disease

          -  Previous treatment with levodopa

          -  Psychological problems

          -  Ocular abnormalities other than those associated with albinism

          -  Pregnant, nursing or planning to become pregnant during study

          -  Known allergy to levodopa/carbidopa
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: A 12-week Human Trial to Compare the Efficacy and Safety of Polycan on Bone Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  They were required to have reduced bone density but no evidence of osteoporosis or
             osteopenia by Dual-emission X-ray absorptiometry (DEXA) scan (T ≥ -1.0 in the lumbar
             spine).

          -  Perimenopausal women : aged 40-70

        Exclusion Criteria:

          -  Women with a body mass index (BMI) >30 kg/m2 or who were being treated with estrogens,
             corticosteroids, or bisphosphonates, or who had significant illness affecting bone
             metabolism were excluded
Female
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Efficacy and Safety Study for the Treatment of Dysfunctional Uterine Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Women 18 years or older

          -  And with a diagnosis of dysfunctional uterine bleeding without organic pathology

          -  And with at least one of the following symptoms: prolonged, frequent or excessive
             bleeding.

        Exclusion Criteria:

          -  The use of steroidal oral contraceptives, or any drug that could alter oral
             contraception metabolism will be prohibited during the study.

          -  Women with a history of endometrial ablation or dilatation and curettage within 2
             months prior to study start will be excluded.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Electronic Tools to Assist With Identification of and Counseling for Overweight Patients

Eligibility criteria:
Inclusion Criteria (physicians):

          -  Consenting physicians from the Northwestern Memorial General Internal Medicine (NMFF
             GIM) practice

        Exclusion Criteria (physicians):

          -  Study investigators will be excluded from participation (Dr. David Baker, Dr. Joyce
             Tang)

        Inclusion Criteria (patients):

          -  Adults ages 18-65 seen at the NMFF GIM who are patients of consenting physicians

          -  Have at least one appointment at the NMFF GIM clinic between 9/1/09-2/28/10

          -  Body mass index (BMI) 27-29.9 at one or more visits between 9/1/09-2/28/10

        Exclusion Criteria (patients):

          -  Patients without at least one recorded height measurement from any prior visit or
             without weight information from a visit within the 6 month target window will be
             excluded due to inability to calculate BMI.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

Eligibility criteria:
Eligible subjects must have one of the conditions listed below and be enrolled in-person at
        one of the participating clinical centers.Contact the study coordinator at the location
        nearest you for more information about participation.

          -  Marfan syndrome

          -  Turner syndrome

          -  Ehlers-Danlos syndrome

          -  Loeys-Dietz syndrome

          -  FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 genetic mutation

          -  Bicuspid aortic valve without known family history

          -  Bicuspid aortic valve with family history

          -  Bicuspid aortic valve with coarctation

          -  Familial Thoracic Aortic Aneurysm and DissectionsYes

          -  Shprintzen-Goldberg syndrome

          -  Other aneurysms and dissections of the thoracic aorta not due to trauma, <50yo

          -  Other congenital heart disease (e.g., Tetralogy of Fallot, coarctation)

        Exclusion Criteria:

          -  Inability of the patient, parent or guardian to give consent.

          -  Unwillingness to provide a blood or buccal specimen.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: MSCT Chest in Suspected COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  patients presented by fever, myalgia or respiratory symptoms

          -  Close contact with a confirmed COVID-19 patient

        Exclusion Criteria:

          -  pediatric patients

          -  patients refuse any of the following: MSCT chest, taking of nasopharyngeal swabs or
             blood sample

          -  chest MSCT -Angiography was done for suspected vascular complications (e.g., pulmonary
             embolism)

          -  severely dyspneic patients with motion artifact on MSCT images.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Directional Versus Nondirectional DBS for ET

Eligibility criteria:
Inclusion Criteria:

          -  A tremor syndrome of bilateral upper limb action tremor with at least 3 years'
             duration

        Exclusion Criteria:

          -  Patients who have decided not to receive DBS for control of their
             medication-refractory essential tremor.

          -  Patients with secondary tremor (ie not Essential Tremor), such as side effects from
             medications, secondary to another identified neurologic disease (eg multiple
             sclerosis, -----Parkinson's disease, dystonia).

          -  Prior history of deep brain stimulation.

          -  Prior history of thalamotomy.

          -  A history or signs of dystonia, ataxia or parkinsonism.

          -  Task specific tremor.

          -  Orthostatic tremor.

          -  Patients with cardiac pacemakers, defibrillators, or neurostimulators.

          -  Patients who require MRI, ECT, rTMS, or diathermy.

          -  Subjects with other type of neurological disease or injury.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Immunogenetics Predictors With COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Adult subjects (> 18 years old) with COVID 19 infection.The patients will be
             classified on the basis of the severity of the disease.

        Exclusion Criteria:

          -  -patients have symptoms of fever and /or respiratory with negative PCR for COVID-19.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Zonisamide in the Treatment of Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for
             definite or probable Essential Tremor.

          2. Age: 18 years or over.

          3. Willingness and ability to comply with the study requirements and give informed
             consent.

        Exclusion Criteria:

          1. Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or
             Stevens-Johnson syndrome.

          2. Known alcohol or substance abuse in previous 12 months.

          3. Positive pregnancy test.

          4. Unwillingness to use adequate contraceptive methods if of childbearing potential.

          5. Known allergy to sulfonamides.

          6. Laboratory abnormalities prior to onset of trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Outpatient Treatment of Constipation in Children

Eligibility criteria:
Inclusion Criteria:

          -  Children between 2 and 16 years and referral to our out patient clinic with either
             constipation or fecal incontinence.

          -  Patients must fulfill the Rome III criteria of constipation, which mean they must have
             at least 2 of the following characteristics: fewer than 3 bowel movements weekly, more
             than 1 episode of fecal incontinence weekly, large stools in the rectum by digital
             rectal examination or palpable on abdominal examination, occasional passing of large
             stools, display of retentive posturing and withholding behavior, and painful
             defecation.

        Exclusion Criteria:

          -  Children with known organic causes of constipation, including Hirschsprungs disease,
             spinal and anal congenital abnormalities, previous surgery on the colon, inflammatory
             bowel disease, allergy and metabolic or endocrine diseases.

          -  Children receiving drugs known to affect bowel function during a 2 month period before
             initiation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction