Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Regular Physical Exercise in Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Patients with conclusive DMD diagnosis

          -  Written consent

          -  Able to perform physical exercise and answer questions

        Exclusion Criteria:

          -  Lack of consent

          -  Cognitive disabled unable to answer questionnaire, understand instructions, and able
             to know what they participate in.

          -  Language difficulties
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Study to Determine the Effect of Food on the Absorption of an Oral Testosterone Undecanoate Formulation

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  Age 18-65

          -  Morning serum testosterone (T) <300 ng/dL on two occasions

        Exclusion Criteria:

          -  Significant intercurrent disease

          -  Abnormal prostate digital rectal exam, elevated PSA, AUA symptom score >15 or history
             of prostate cancer.

          -  Serum transaminases >2 times upper limit of normal

          -  Serum bilirubin >2.0 mg/dL

          -  Hematocrit <35% or >50%

          -  BMI >36

          -  Untreated, obstructive sleep apnea.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: EBUS vs EUS-B for Diagnosing Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical and radiologic suspicion of sarcoidosis stage I (mediastinal or hilar
             lymphadenopathy) or stage II (lymphadenopathy and interparenchymal abnormalities)

          -  Indication for tissue verification of noncaseating granuloma's

          -  Provision of a written informed consent

        Exclusion Criteria:

          -  Life expectancy of less than 6 months

          -  Obvious organ involvement of sarcoidosis with the possibility to confirm granulomas
             with a minimally invasive diagnostic procedure (eg skin lesion or superficial lymph
             node)

          -  Positive acid-fast bacilli sputum test

          -  Contra-indication for endosonography

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts

Eligibility criteria:
Inclusion Criteria:

          -  Men and women over 18 and under 65.

          -  Household contact with a confirmed case of COVID-19 by PCR for Sars-CoV-2.

          -  Initiate study medication within 4 days from the last close contact with the index
             case.

          -  The patient must not present symptoms suggestive of Covid19 (cough, dyspnea, fever>
             37.5 C, fatigue, sore throat, myalgia, diarrhoea) at the time of admission to the
             study and from previous 14 days.

          -  Informed consent from the patient or legal representative.

        Exclusion Criteria:

          -  History of infection confirmed by SARS-CoV-2.

          -  Positive IgG antibodies test for SARS-CoV-2 at the time of admission.

          -  Have received any dose of nitazoxanide within 7 days prior to screening.

          -  Known hypersensitivity to any of the study medication components.

          -  Use of any investigational or unregistered drug or vaccine within 30 days prior to
             screening, or use planned during the study period.

          -  Inability to comply with study procedures.

          -  Current breastfeeding.

          -  Pregnancy.

          -  Intolerance or inability to take oral medication.

          -  History of severe liver disease (Child-Pugh B or C) and/or chronic kidney disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Does Adding Cryostimulation to Conservative Care Help in Managing Chronic Lateral Epicondylitis? a Pilote Study

Eligibility criteria:
Inclusion Criteria:

          -  Must have pain at lateral elbow (lateral epicondylitis) for at least six months

          -  Pain must not come from trauma

          -  Painful palpation of the lateral epicondyle

          -  At least one out of two positive test: Cozen's, Mill's

        Exclusion Criteria:

          -  Fibromyalgia

          -  Diabetes

          -  Patient taking more than three medications at the time of inclusion

          -  Cervical radiculopathy

          -  Painful shoulder

          -  Cold intolerance / allergies

          -  Smoking

          -  Cortisone infiltration at the painful lateral epicondyle in the month previous to the
             inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients

Eligibility criteria:
Inclusion Criteria:

          1. histologically or cytologically confirmed diagnosis of gastric adenocarcinoma or
             gastroesophageal junction adenoca (i.e. an adenocarcinoma with > 50% extension in the
             stomach)

          2. patients must present with stage IV disease not amenable to surgery, radiation or
             combined modality therapy with curative intent. Patients previously undergoing local
             treatment (surgery and/or radiation) must have subsequently progressed or recurred

          3. measurable or evaluable disease according to RECIST

          4. age, 18 years or older

          5. ECOG performance status 0 - 2

          6. adequate organ function as defined by the following criteria absolute neutrophil count
             (ANC) ≥ 1,500/ul platelets ≥ 100,000/ul AST/ALT ≤ 2.5 x ULN, ≤ 5.0 x ULN if liver
             involvement Total serum bilirubin ≤ 3.0 mg/dL

          7. signed written informed consent

        Exclusion Criteria:

          1. severe co-morbid illness and/or active infections

          2. pregnant or lactating women

          3. active CNS metastases not controllable with radiotherapy or corticosteroids

          4. active and uncontrollable bleeding from gastrointestinal tract

          5. known history of hypersensitivity to study drugs

          6. patients who are already on statin treatment for hyperlipidemia control (if ≥ 1 year
             interval from the last statin dose, the patient is eligible for study entry)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Effects of Joint Effusion on Proprioception

Eligibility criteria:
Inclusion Criteria:

        Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):

          1. Kellgren and Lawrence (K/L) grade ≥II

          2. morning stiffness <30 min in duration

          3. crepitus on movement of the knee joint

          4. bony tenderness at the knee joint margins

          5. palpable or visible bony enlargement

          6. no palpable warmth.

        Exclusion Criteria:

          1. the presence of knee joint effusion determined by ultrasonography

          2. a history of knee injury or surgery

          3. a history of knee injection within 3 months

          4. a history of inflammatory arthritis

          5. taking anticoagulants

          6. balance or gait disturbance

          7. diabetes mellitus.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Fascial Therapy in Elbow Hemophilic Arthropathy

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A and B

          -  Patients adults (over 18 years)

          -  Patients diagnosed with hemophilic arthropathy of the elbow (by clinical assessment
             with the Hemophilia Joint Health Score)

          -  Patients pn prophylactic treatment with FVIII / FIX concentrates.

        Exclusion Criteria:

          -  Patients without ambulation ability

          -  Patients with inhibitors

          -  Patients with neurological or cognitive alterations that impede the comprehension of
             the questionnaires and physical tests

          -  Patients who have not signed the informed consent document.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: The Berkeley Orthokeratology Study

Eligibility criteria:
Myopic volunteers, ages 20 to 35, who had not worn contact lenses were eligible to
        participate in the study if they were free of ocular disease, were in good physical health,
        and were not taking systemic medications that could have ocular side effects. In addition,
        eligibility was limited to persons with corneal curvature between 40.50 and 47.00 D
        (flatter keratometry reading), corrected visual acuity of 6/6 (20/20) or better in each
        eye, astigmatism less than 0.75 D, anisometropia less than 1 D, and myopia between 1 and 4
        D.
No condition on gender to be admitted to the trial.

Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART

Eligibility criteria:
Inclusion Criteria:

          1. Age: between 35 and 40 years of age,

          2. Physiological menstrual cycles (24-35 day cycle),

          3. Normal endocrine function (normal PRL and TSH, FSH ≤ 15 IU / ml),

          4. Transvaginal ultrasound (TVS) without pathological findings,

          5. Free personal medical history,

          6. Indication for IVF / ICSI (NICE, 2016)

          7. 1st or 2nd IVF / ICSI cycle

        Exclusion Criteria:

          1. Endocrine or metabolic disorders, e.g. PCO (S)

          2. Pathology of the uterus and / or endometrium,

          3. Pelvic inflammatory disease (PID),

          4. Basal FSH levels> 15 IU / ml,

          5. Surgery in the ovaries,

          6. Body Mass Index (BMI) ≥ 35 kg / m2,

          7. Age: <35 years &> 41 years old
Female
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction