Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Periodontal Phenotype Study (Tooth Extraction)

Eligibility criteria:
Inclusion Criteria:

          -  Age: 18 to 75 years

          -  Gender: No restriction

          -  Subjects must require a single-rooted tooth extraction (Tooth deemed as periodontally
             and/or restoratively hopeless) in the maxillary anterior region (first premolar to
             first premolar)

          -  Subjects must be able and willing to follow instructions related to the study
             procedures

          -  Subjects must have read, understood and signed an informed consent form

        Exclusion Criteria:

          -  More than 1 mm of recession present on the tooth planned for extraction and inclusion
             in the study

          -  Reported allergy or hypersensitivity to any of the products to be used in the study

          -  Severe hematologic disorders, such as hemophilia or leukemia

          -  Active severe infectious diseases that may compromise normal healing

          -  Liver or kidney dysfunction/failure

          -  Currently under cancer treatment or within 18 months from completion of radio- or
             chemotherapy

          -  Subjects who have a long-term history of oral bisphosphonate use (i.e. 10 years or
             more)

          -  Subjects with a history of IV bisphosphonates

          -  Subjects with uncontrolled diabetes, defined as Hba1c > 7.0

          -  Subjects with severe metabolic bone diseases, such as Paget's disease of bone, will be
             excluded

          -  Pregnant women or nursing mothers

          -  Heavy smokers: Subjects who have smoked >10 cigarettes per day within 6 months of
             study onset

          -  Concomitant medications: Subjects on concomitant drug therapy for systemic conditions
             that may affect the outcomes of the study will not be included in the study.

        NOTE: Occasional, short-term use (7-14 days) of analgesics or common cold medications is
        permitted. Use of such medications will be reviewed and recorded by the investigator.

        - Any other non-specified reason that from the point of views of the investigators will
        make a candidate not a suitable subject for the study (e.g. limited mouth opening).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction