Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments

Eligibility criteria:
Inclusion Criteria:

          -  Male between the ages of 18 and 35

          -  Weight of at least 110 pounds

          -  Generally healthy (defined as an absence of a disease or medical condition which could
             potentially be negatively influenced by study participation or confound study results)

          -  Low levels of habitual creatine consumption, defined as consuming an average of <10
             g/week of creatine from all supplemental sources within the three months prior to
             study initiation

          -  Willingness to report to baseline and final assessments with a similar haircut (i.e.
             willingness to replicate baseline haircut prior final assessment, to the best of his
             ability) and one that allows for evaluation of hair growth patterns (e.g., not a
             completely shaved head that disallows visualization of the hairline)

          -  Willingness to adhere to the supplementation protocol for the duration of the study
             (i.e., 6 months of daily supplementation with 5 grams per day of creatine monohydrate
             or placebo) and abstain from additional creatine supplement ingestion during this
             time.

          -  Willingness to abstain from any treatments related to hair loss or hair growth for the
             duration of the study

          -  Willingness to maintain normal practices regarding hair products (i.e. continue to use
             regular shampoo, conditioner, and other products over the duration of the study and
             abstain from switching products during the study if at all possible)

        Exclusion Criteria:

          -  Failing to meet any of the aforementioned inclusion criteria

          -  Presence of pacemaker or any electrical device (due to electrical currents
             administered by bioimpedance devices used to assess body composition)

          -  Individual currently participates in any type of hair loss treatment or procedure or
             has undergone any such treatment or procedure within the last 12 months
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Entailment