Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: A Clinical Trial of CoFactor Formulations and Leucovorin Administered Intravenously in Healthy, Adult Subjects.

Eligibility criteria:
Inclusion Criteria:

          -  Males and Females age 18-65 inclusive at screening.

          -  Subject has to agree to practice abstinence or medically accepted contraception and
             not to participate in sperm donation or in vitro fertilization.

          -  Body Mass Index in the range of 18 to 30 kg/m2 and body weight of 45 to 95 kg.

          -  Subject must be healthy as determined by the investigator on the basis of screening
             evaluations.

          -  Subject must be nonsmoker or smoker of fewer than 10 cigarettes per day as determined
             by history. Must be able to abstain from smoking during the in-clinic stay.

        Exclusion Criteria:

          -  Presence of clinically significant illness within 21 days prior to dosing, viral or
             bacterial infection, or documented drug allergies that may affect subject's safety
             during the study.

          -  Laboratory or clinical evidence suggestive of disease.

          -  Clinically significant or predisposing disorder that may interfere with the
             absorption, distribution, metabolism and/or excretion of drugs.

          -  History of drug abuse within 1 year of dosing and/or admitted alcohol abuse or history
             of alcohol use that may interfere with the ability to comply.

          -  Pregnant, lactating, or positive pregnancy test.

          -  Clinically significant electrocardiogram abnormalities.

          -  History of positive test for hepatitis B or C, or HIV.

          -  Positive findings of urine narcotic screen.

          -  History of drug allergy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Does Flushing the Uterine Cavity With Follicular Fluid After Ovum Pick-up Improve Implantation Rates in ICSI Cycles?

Eligibility criteria:
Inclusion Criteria:

          1. Maternal age ranges from 20-38 years.

          2. Basal FSH < 10 mIU/ml.

          3. BMI < 35 kg/m2.

          4. Estradiol level > 1000 at the day of HCG administration.

          5. Estradiol level < 4000 at the day of HCG administration.

        Exclusion Criteria:

          1. Presence of Endometriosis.

          2. Presence of Hydrosalpinx.

          3. Presence of vaginal infection.

          4. Presence of galactorrhea.

          5. Presence of hormonal disorders.

          6. Severe male factor infertility:

             Sperm Count < one million. Marked malformation

          7. history of recurrent abortion.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 38 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors

Eligibility criteria:
Inclusion Criteria:

          -  patients with the Schnitzler syndrome according to criteria established by Lipsker D
             et al. Medicine (Baltimore) 2001;80:37-44

        Exclusion Criteria:

          -  children and pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Analysis of Toxins in Follicle Fluid

Eligibility criteria:
Inclusion Criteria:

          -  healthy females without sterility factors

        Exclusion Criteria:

          -  job-related exposition to pollutants

          -  low responder
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Development of the Danish Prospective Sarcoidosis Registry and Baseline Characteristics of a Danish Sarcoidosis Cohort

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of sarcoidosis

          -  Signed informed consent

        Exclusion Criteria:

          -  Inability or unwillingness to adhere to the study

          -  Inability to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Determining Disease Activity Biomarkers in Individuals With Giant Cell Arteritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of GCA, meeting at least 3 of the following 5 American College of
             Rheumatology (ACR) criteria for the diagnosis of GCA:

               1. At least 50 years of age at disease onset

               2. New onset or new type of localized pain in the head

               3. Temporal artery abnormality (i.e., temporal artery tenderness to palpation or
                  decreased pulsation unrelated to arteriosclerosis of cervical arteries)

               4. ESR of greater than 40 mm in the first hour by the Westergren method

               5. Temporal artery biopsy showing vasculitis characterized by a predominance of
                  mononuclear cell infiltration or granulomatous inflammation, usually with
                  multinucleated giant cells

        Exclusion Criteria:

          -  Unable to give informed consent and sign the consent form
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant Laparoscopic Inguinal or Umbilical Herniorrhaphy

Eligibility criteria:
Inclusion Criteria:

          1. Man ≥18 years

          2. Has a planned unilateral inguinal herniorrhaphy (laparoscopy, transabdominal
             preperitoneal [TAPP] approach or totally extraperitoneal [TEP] approach) or
             laparoscopic umbilical herniorrhaphy to be performed according to standard surgical
             technique under general anesthesia.

          3. Willing to use opioid rescue analgesia.

        Exclusion Criteria:

          1. Has a known hypersensitivity to amide local anesthetics, opioids, or bovine products.

          2. Scheduled for bilateral inguinal herniorrhaphy.

          3. Undergone a prior herniorrhaphy at the location scheduled for repair.

          4. Undergone major surgery within 3 months of the scheduled herniorrhaphy.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Chronic Versus Intermittent Deep Brain Stimulation for Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  individuals with essential tremor who are at least 6 months status-post thalamic
             stimulator placement

          -  maintained a consistent chronic or intermittent stimulation schedule for at least 4
             consecutive weeks prior to study enrollment

          -  no changes in stimulation parameters for at least 2 consecutive months prior to study
             enrollment

        Exclusion Criteria:

          -  patients with clinically significant dementia (i.e., a score less than 24 out of 30 on
             the Mini Mental Status Exam14)

          -  women who are not post-menopausal

          -  patients with other significant neurological or psychiatric disease other than
             essential tremor

          -  patients treated with pallidotomy or thalamotomy

          -  patients with significant psychiatric disturbance as determined by Diagnostic and
             Statistical Manual-IV criteria which would make informed consent/cooperation
             problematic
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  AD patients: clinical dementia rating between 0.5 and 2 free and cued recall test
             (Grober and Buschke) cued-recall < 18/48 and total recall < 40/48

          -  atypical AD : i visual-spatial disorder and respect of episodic memory progressive
             evolution, Balint syndrome ii progressive language disorder constituted of logopenic
             aphasia respect of episodic memory

          -  controls: age over 30 MMSE over or equal to 27 normal neuropsychiatric state for age
             and education level

        Exclusion Criteria:

          -  for every patients : psychiatric disorders age under18 absence of social security
             counter indication to MRI supposed or actual alcoholism or drug addiction pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment