Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops

Eligibility criteria:
Inclusion Criteria:

          -  SS was diagnosed according to the SS European Criteria

          -  chronic symptoms of burning, foreign body sensation, itching in both eyes

          -  daily need of artificial tears

          -  abnormal Schirmer (ST) I test < 5mm or rose Bengal staining (RBS) ≥ 4, or break up
             time (BUT) < 5 seconds.

        Exclusion Criteria:

          -  any structural abnormalities (lid scarring, entropion, trichiasis, etc.)

          -  any inflammation or active structural change in the iris or anterior chamber

          -  glaucoma

          -  previous eye surgery or punctual occlusion

          -  use of any other topical medication other than artificial tears

          -  any systemic or topical antibacterial or antiinflammatory drug treatment 90 days
             before study entry

          -  contact lens wearer

          -  the presence of any corneal infection

          -  any corneal diseases (marginal ulcer, opacity, scar, bullous keratopathy,
             conjunctivochalasis, symblepharon or tumor)

          -  pregnancy

          -  change in the immunosuppressive systemic therapy 90 days before study entry
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effect of an Education Programme for Patients With Osteoarthritis in Primary Care - a Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoarthritis

        Exclusion Criteria:

          -  Must be able to speak and understand swedish
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A Gene Delivery Study to Evaluate the Safety of and Expression From SRP-9001 in Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
Inclusion Criteria:

          -  Is male at birth, ambulatory and from 4 to under 8 years of age at time of
             randomization.

          -  Definitive diagnosis of Duchenne Muscular Dystrophy based on documented clinical
             findings and prior genetic testing

          -  Ability to cooperate with motor assessment testing.

          -  Stable dose equivalent of oral corticosteroids for at least 12 weeks.

          -  rAAVrh74 antibody titers are not elevated as per protocol-specified requirements.

        Exclusion Criteria:

          -  Has a concomitant illness, autoimmune disease, chronic drug treatment, and/or
             cognitive delay/impairment that in the opinion of the Investigator creates unnecessary
             risks for gene transfer.

          -  Exposure to gene therapy, investigational medication, or any treatment designed to
             increase dystrophin expression within protocol specified time limits.

          -  Abnormality in protocol-specified diagnostic evaluations or laboratory tests.

        Other inclusion/exclusion criteria apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: S-1 and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage III Stomach Cancer

Eligibility criteria:
DISEASE CHARACTERISTICS:

          -  Histologically confirmed gastric adenocarcinoma, including type II or type III
             adenocarcinoma of the esophagogastric junction

               -  Stage III disease

                    -  T3 or T4 and/or N2

                         -  No stage IV disease

               -  Helical CT scan and laparoscopic staging required

          -  Potentially resectable disease

        PATIENT CHARACTERISTICS:

        Age

          -  20 and over

        Performance status

          -  ECOG 0-1

        Life expectancy

          -  Not specified

        Hematopoietic

          -  WBC ≥ 4,000/mm³, but < 12,000/mm³

          -  Granulocyte count ≥ 2,000/mm³

          -  Platelet count ≥ 100,000/mm³

          -  Hemoglobin ≥ 9.0 g/dL

        Hepatic

          -  AST and ALT ≤ 2.5 times upper limit of normal

          -  Bilirubin ≤ 1.5 mg/dL

        Renal

          -  Creatinine clearance ≥ 50 mL/min

        Pulmonary

          -  Arterial oxygen pressure (PaO_2) ≥ 70 mm Hg on room air

        Other

          -  Able to take oral medications

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  Not specified

        Chemotherapy

          -  No prior chemotherapy for gastric cancer

        Endocrine therapy

          -  Not specified

        Radiotherapy

          -  No prior radiotherapy for gastric cancer

        Surgery

          -  No prior surgery for gastric cancer

        Other

          -  No other prior therapy for gastric cancer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

Eligibility criteria:
-  INCLUSION CRITERIA:

        Initial Enrollment:

        -An individual who harbors a pathogenic, or likely pathogenic, CDH1 germline variant.

        Note: individuals with CDH1 variant classified as any of the following are not eligible:

          -  variant of uncertain significance

          -  benign

          -  likely benign.

               -  Age greater than or equal to 18 years.

               -  Physiologically able to undergo upper endoscopy.

               -  Ability of subject to understand and the willingness to sign a written informed
                  consent document.

        EXCLUSION CRITERIA:

          -  Known bleeding disorder or thrombocytopenia that is a contraindication to endoscopic
             biopsy.

          -  Unstable angina or recent (within 3 months) myocardial infarction.

          -  Any clinical contraindication to general anesthesia.

        Re-Enrollment:

        INCLUSION CRITERIA:

          -  Subject must have previously been enrolled on the study and must have undergone
             endoscopy. Note: Subject may re-enroll only once after initial endoscopy performed

          -  Subject must have clinical need for a repeat endoscopy

          -  Prior on-protocol endoscopy must have occurred at least 6 months (+/- 2 weeks) and no
             greater than 18 months (+/- 4 weeks)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Validation of the Aktiia SA PulseWatch OBPM Device at the Wrist Against Invasive Blood Pressure Measurements

Eligibility criteria:
Inclusion criteria:

          -  Age ≥ 18 years

          -  No significant non-invasive systolic blood pressure difference between left arm and
             right arm (difference <20mmHg in systolic arterial pressure)

          -  Patient requires continuous monitoring of diastolic and systolic blood pressure
             continuously via a radial arterial line;

          -  Patient information and informed consent is obtained following the procedures
             described in CIP

        Exclusion criteria:

          -  Arrythmias: tachycardia (resting heart rate > 120/min) at time of study inclusion

          -  Atrial fibrillation

          -  Psychomotor agitation

          -  Significant bruises or trauma on forearm

          -  Intravenous canula around the wrist with impossibility to place the device (Aktiia
             OBPM PulseWatch) around the wrist
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Phase 2B Extension Study of Ataluren (PTC124) in Duchenne/Becker Muscular Dystrophy (DMD/BMD)

Eligibility criteria:
Inclusion Criteria:

          -  Completion of blinded study drug treatment in the previous Phase 2b study
             (PTC124-GD-007-DMD).

          -  Ability to provide written informed consent (parental/guardian consent if
             applicable)/assent (if less than [<]18 years of age).

          -  In participants who are sexually active, willingness to abstain from sexual
             intercourse or employ a barrier or medical method of contraception during PTC124
             administration and the 6-week follow up period.

          -  Willingness and ability to comply with scheduled visits, drug administration plan,
             study procedures, laboratory tests, and study restrictions.

        Exclusion Criteria:

          -  Known hypersensitivity to any of the ingredients or excipients of the study drug
             (Litesse® UltraTM [refined polydextrose], polyethylene glycol 3350, Lutrol® micro F127
             [poloxamer 407], mannitol 25C, crospovidone XL10, hydroxyethyl cellulose, vanilla,
             Cab-O-Sil® M5P [colloidal silica], magnesium stearate).

          -  Ongoing participation in any other therapeutic clinical trial.

          -  Prior or ongoing medical condition (for example, concomitant illness, psychiatric
             condition, behavioral disorder, alcoholism, drug abuse), medical history, physical
             findings, ECG findings, or laboratory abnormality that, in the investigator's opinion,
             could adversely affect the safety of the subject, makes it unlikely that the course of
             treatment or follow up would be completed, or could impair the assessment of study
             results.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein

Eligibility criteria:
Inclusion Criteria:

        patients scheduled to upper digestive endoscopy for diagnostic purposes due to complaints
        of epigastric burning.

        Exclusion Criteria:

        American Society of Anesthesiologists (ASA) score above II, diabetes mellitus, pregnancy,
        renal or hepatic failure, gastroesophageal reflux, acute cholecystitis, use of
        corticosteroids up to 6 months previously, use of any prokynetic drug up to 6 weeks, and
        any noncompliance or violation on the assigned protocol of preoperative fasting.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Phase II Dose-Ranging Study of OrthoDerm Patch for Patients With Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  males >18 yr and < 70 yr

          -  BMI < 38

          -  chronic lateral epicondylitis (symptomatic > 3 mo)

          -  pain on provocation >/- 4 on 11 point scale

        Exclusion Criteria:

          -  patients on other pain medications

          -  bilateral elbow pain

          -  any humerus elbow or forearm fracture or surgery

          -  signs of injury other than lateral epicondylitis

          -  any concomitant disease or pain of the upper extremity

          -  orthostatic hypotension

          -  patients taking MAO inhibitors, phosphodiesterase inhibitors, adrenergic agents

          -  pregnant or nursing women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction