Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Kinematic-guided BoNT-A Treatment for ET and PD Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Consenting male and female participants, aged 18 years to 80 years

          -  PD individuals diagnosed by UK Brain Bank Criteria with stage H&Y2-3 disease or ET
             with hand tremor in their motor dominant hand

          -  Stable IPD/ET medication management for the 6 month duration prior to their enrollment
             in the study

          -  Individuals with IPD will be eligible for the study only if tremor is their primary
             and most bothersome symptom as determined by clinical exam and patient report

          -  Participants who are botulinum toxin naïve for tremor management

        Exclusion Criteria:

          -  History of stroke

          -  Muscle weakness or any related compartmental muscle syndrome

          -  Smoking

          -  Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic
             agonists (e.g. salbutamol))

          -  Contradictions per the Xeomin® drug monograph

          -  Patients prescribed zonisamide
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effect of Cis-9-cetylmyristoleate in Sub-healthy Subjects Presenting With Knee Joint Pain

Eligibility criteria:
Inclusion Criteria:

          -  sub-healthy persons >18 years of age and knee joint pain with a 0-10 numerical rating
             scale (NRS) pain score ≤ 4.

        Exclusion Criteria:

          -  current medication use related to arthritis;

          -  current use of FAC containing products;

          -  clinical or radiological diagnosis as moderate degree arthritis accompanied by
             peri-articular spur formation, irregular joint margin, and/or subchondral cyst;

          -  previous history of knee surgery;

          -  pregnant, breastfeeding, or practicing contraception with reliable methods, or not
             accepting our guidelines during the research periods;

          -  major pain other than knee joint pain;

          -  current treatment of gastritis or gastric ulcer;

          -  abnormal screening laboratory results;

          -  major cardiac, renal disease, or disability that could affect adverse effect
             assessment or interfere with study completion when enrolled;

          -  history of major procedures or operations that might affect study results;

          -  enrollment in another clinical trial or human application testing; and

          -  judged as unsuitable for human application testing.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Gait and REM Sleep Behavior Disorder

Eligibility criteria:
Inclusion Criteria:

          -  Specific inclusion criteria for RBD patients - to reach the diagnosis criteria of RBD
             (International Classification of Sleep Disorders 2)

          -  Specific inclusion criteria for PD patients - to reach the diagnosis criteria of
             idiopathic PD (Queen Square Brain Bank) - Hoehn Yahr score ≤ 2

        Exclusion Criteria:

          -  Specific exclusion criteria for RBD patients - diagnosis of PD - other pathology
             associated to RBD diagnosis - presence of antiparkinsonism medication

          -  Specific exclusion criteria for PD patients - clinical signs of parkinsonian syndrome-
             Mini Mental State Examination < 24/30- gait disorder clinically observable

          -  Specific exclusion criteria for controls - neurological disease- gait disorder
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Baricitinib Therapy in COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  SARS-Co-V2 positivitity to the nasal-swab by reverse-transcriptase-polymerase chain-
             reaction (RT-PCR) assay tested by the local diagnostic laboratory

          -  Age >18 and <85 years

          -  Presence of at least 3 of the following symptoms as present fever, cough, myalgia,
             fatigue.

          -  Presence of radiological findings of pneumonia assessed by chest radiograph, computed
             tomography, or pulmonary ultrasound.

          -  Peripheral capillary oxygen saturation (SpO2) > 92% on room air at screening

          -  PaO2/FiO2 >100-300 mmHg at arterial blood gas analysis.

        Exclusion Criteria:

          -  Age < 18 and >85

          -  History of thrombophlebitis

          -  Latent tuberculosis infection (based on the positivity to QuantiFERON Plus positivity,
             Qiagen, Germany)

          -  Pregnancy and lactation

          -  History of malignancies over the previous 5 years, current diagnosis of malignancy

          -  Inability or unwillingness to sign a written consent.

          -  Transaminases values 4-fold higher than the upper normal limit.

          -  HBV and HCV positivity.

          -  Current Herpes zoster infection.

          -  Evidence of concomitant bacterial infections.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension

Eligibility criteria:
Inclusion Criteria:

          -  Subjects should be over 60 years of age with essential isolated systolic hypertension
             (stage I-II base on recommendation of JNC-VII) for the hypertension group and normal
             blood pressure in the healthy group. Good communication, independent physical
             activity. The healthy subject should be non-smokers, non-obese, free of any signs or
             symptoms of disease as revealed by medical history

        Exclusion Criteria:

          -  Essential hypertension stage III or secondary hypertension, any history of respiratory
             disease, heart disease, renal disease, blindness, cerebrovascular disease, exercise
             limited by pain
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs

Eligibility criteria:
Inclusion Criteria:

        Known AFF group

          1. A subject must have experienced an incomplete atypical low trauma fracture of the
             femoral shaft;

          2. Is a patient at the UHN osteoporosis clinic.

        Comparison Group

          1. Must be scheduled for a bone mineral density scan at UHN

          2. Have been on any bisphosphonate for 5 years or longer, and;

          3. Have unexplained symptoms of leg, hip, thigh, or knee pain.

        Exclusion Criteria:

          -  There are no exclusions
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Vaginal Hysterectomy Versus Laparoscopically Assisted Vaginal Hysterectomy for Large Uteri

Eligibility criteria:
Inclusion Criteria:

          1. Age between 40 and 70 years.

          2. Uterine weight more than 280gm. the weight will be estimated sonographically using
             algebraic formula by Kung and Chang expressed in weights and measurements: weight(g)=
             50+(4/3 x π(Pi) x L/2 x W/2 x AP/2) where (L) is the length of the uterus from the
             dome of the fundus to the level of the external os and (W) is the maximum width of the
             uterus at the level of the cornua and (AP) is the anteroposterior diameter of the
             uterus . Both (W) and (AP) will be taken perpendicular to the axis of the uterine
             length.

          3. Presence of a benign cause for hysterectomy. e.g: fibroid uterus, simple endometrial
             hyperplasia not responding to medical treatment and adenomyosis.

        Exclusion Criteria:

          1. Patients medically unfit for laparoscopy as severely compromised cardiac patients.

          2. Obese patients (BMI>30).

          3. Presence of endometriosis.

          4. Previous myomectomy

          5. Presence of adnexal mass

          6. Known or suspected gynecological malignancy.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Phase 1/2 Study in Boys With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Written informed consent from parent or legal guardian prior to participation and, for
             patients who are 7 years of age, written assent from patient

          -  Diagnosis of DMD based on a clinical phenotype with increased serum CK and the
             presence of a mutation in the dystrophin gene known to be associated with a DMD
             phenotype

          -  Ability to walk independently (assistive devices are permitted)

          -  Adequate immunization for influenza and varicella

        Exclusion Criteria:

          -  Use of corticosteroids within prior 6 months of treatment initiation or planning to
             initiate steroid therapy within the next 6 months

          -  Other prior or ongoing significant medical conditions

          -  Exposure to another investigational drug (such as eteplirsen or idebenone) within 28
             days prior to start of study treatment or ongoing participation in any other
             therapeutic clinical trial

               -  Note: There are separate criteria for patients who participated in Part A versus
                  newly enrolling patients. New patients must meet all of the Part A entry criteria
                  to participate in Part B.

        Patients who participated in Part A must meet the following criteria to participate in Part
        B:

          -  Completed Part A

          -  Continue to meet all of the Part A entry criteria, including an absence of safety
             concerns (however, patients may be ≥8 years of age)

        There are no entry criteria for Part C; all patients who complete Part B will automatically
        continue in Part C
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Mirvaso® Gel and Dysport® for Erythema and Flushing of Rosacea

Eligibility criteria:
Inclusion Criteria:

          1. Male or female

          2. 18 years of age or older

          3. Clinical diagnosis of rosacea

          4. Moderate to severe persistent facial erythema associated with rosacea at baseline, as
             determined by: a grade of greater than or equal to 3 on the 5 point grading scale1
             (Figure 1)

          5. No known medical conditions that may interfere with study participation

          6. Willingness to not use any products on their face for the duration of the study

          7. Read, understand, and sign informed consent forms

          8. Willingness to sign photography release form

          9. Willing and able to comply with all follow-up requirements

         10. Willingness to undergo treatment using Mirvaso® Gel and Dysport®

        Exclusion Criteria:

          1. Any significant skin disease at treatment area

          2. Any medical condition which could interfere with the treatment

          3. Inability or unwillingness to follow the treatment schedule

          4. Inability or unwillingness to sign the informed consent

          5. Pregnant or lactating

          6. Allergy to cow's milk protein

          7. Previous or current use of Mirvaso® Gel

          8. Known hypersensitivity to Dysport® , Mirvaso® Gel or any of their ingredients

          9. Previous Dysport® treatment 6 months prior to the screening visit
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment