Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of mild-moderate Alzheimer disease (AD)

          -  Mini-Mental State Examination (MMSE) 16-26

          -  Study partner available who has frequent contact with the participant

          -  Good visual and auditory acuity for neuropsychological testing

          -  Education including completion of at least six grades

          -  Must read and speak English fluently

          -  Antidepressants permitted, if stable for 4 weeks prior to screening (and participant
             is not currently depressed and does not have a history of major depression within the
             past 1 year)

          -  Cholinesterase inhibitors permitted, if stable for 12 weeks prior to screening

        Exclusion Criteria:

          -  Any significant neurologic disease other than AD

          -  History of Diabetes Mellitus type I or II

          -  Any contraindications to MRI or PET studies

          -  Major depression, bipolar disorder as described within the past 1 year.

          -  History of schizophrenia

          -  History of alcohol or substance abuse or dependence within the past 2 years

          -  Any significant systemic illness or unstable medical condition, which could lead to
             difficulty complying with the protocol

          -  Current use of specific psychoactive medications

          -  Investigational amyloid lowering therapies are prohibited two months prior to
             screening and for the duration of the trial. Other investigational agents are
             prohibited one month prior to screening and for the duration of the trial.

          -  History of brain cancer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction