Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia

Eligibility criteria:
Inclusion Criteria

          1. 65 years of age or older

          2. Dysphagia diagnosis based on videofluoroscopic swallow study with observed airway
             invasion (Penetration-Aspiration Scale score of 3 or higher)

          3. Ability to provide consent

          4. Ability to submit oral samples

          5. Ability to swallow sachet of probiotic (dissolved in thickened liquid, as needed)

          6. Ability to return to UWHC for week 2 and week 4 visits.

        Exclusion Criteria

          1. Currently taking antibiotics or probiotics

          2. Actively receiving immunosuppressive therapy

          3. Non-oral feeding with inability to swallow probiotic

          4. diagnosis of head and neck cancer or upper airway disease

          5. prior surgery to the head and neck region that would have affected the muscles of
             swallowing or the salivary glands

          6. history of chemotherapy or radiation to the head and neck region

          7. severe periodontal disease.

          8. currently pregnant or planning to become pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Prophylaxis Versus On-demand Therapy Through Economic Report

Eligibility criteria:
Inclusion Criteria:

          -  age ≥ 12 years and ≤ 55 years

          -  severe haemophilia A (FVIII < 1%)

          -  absence of inhibitors (Bethesda titre < 0.6 BU/ml)

          -  Previous Treated Patients (prior exposure days > 200)

          -  Kogenate Bayer administered 20-30 IU/kg -3 times a week, for the prophylaxis group

          -  ≥ 6 joint bleeds requiring treatment with FVIII concentrates in the previous 6 months
             before enrollment, for on-demand group

          -  written informed consent

        Exclusion Criteria:

          -  concomitant severe and chronic diseases or congenital skeletal malformation

          -  unreliability of patient or likelihood of follow-up failure

          -  presence of inhibitors or history of inhibitors (in the previous 2 years)

          -  currently on immune tolerance treatment

          -  hepatic cirrhosis or liver disease in rapid progression

          -  AIDS

          -  platelet count < 75,000/mm3

          -  presence of conditions that influence negatively patient´s compliance

          -  participation in another study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Doxycycline for Lateral Epicondylalgia - RCT

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-65

          -  Pain at the lateral side of the elbow ≥8 weeks

          -  Local tenderness on palpation of the lateral epicondyle

          -  Pain on resisted extension of the wrist

        Exclusion Criteria:

          -  Rheumatic disorder

          -  History of fibromyalgia or generalised pain

          -  Elbow surgery (on the painful side)

          -  Active infection

          -  Glucocorticoid treatment during the duration of symtoms of epicondylalgia

          -  NSAID use within 1 w before presentation and during the study

          -  Pregnancy

          -  Taking drug that might interact with doxycycline
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Creatine for the Treatment of Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria

          -  Diagnosis of probable or definite ALS

          -  At least 5 of 10 testable upper extremity muscle groups (shoulder and elbow
             extensors/flexors and grip) of Medical Research Council (MRC) grade 4 or better

          -  At least 5 years from onset of symptoms

        Exclusion Criteria

          -  Requires tracheostomy ventilation

          -  History of renal disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Gastric Microperfusion in Patients Undergoing Gastroesophageal Resections

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with adenocarcinoma in the gastroesophageal junction

          -  Patients assumed to be resectable

        Exclusion Criteria:

          -  lack of consent

          -  non-adenocarcinomas
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Financial Incentives for Low Socioeconomic Diabetic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of type 2 diabetes for at least 6 months

          -  Diabetes for a maximum of ten years

          -  Updated HbA1c level of between 8.5 and 11% from the last month

          -  Agreement to participate and sign an informed consent

        Exclusion Criteria:

          -  Pregnancy

          -  Insulin therapy

          -  Psychiatric disorder from the first or second line according to the Diagnostic and
             Statistical Manual of mental disorders (DSM)

          -  Active oncology disease [excluding squamous cell carcinoma (SCC) and basal cell
             carcinoma (BCC)

          -  Planed bariatric surgery for the next 6 months

          -  Cardiac hospitalization in the previous year

          -  A severe hypoglycemia event three months prior to allocation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Double Stimulation in Women With Low Prognosis in ART

Eligibility criteria:
Inclusion Criteria:

          -  Age ≤ 40.

          -  AMH ≥ 0.3 ng/ml and ≤ 1.2 ng/ml.

          -  OR 3 ≤ AFC ≤7.

          -  Normal shape of uterus (based on ultrasound).

          -  Body mass index within 28 - 37 kg/m2

        Exclusion Criteria:

          -  Asherman's syndrome.

          -  Endometriosis.

          -  Leiomyomas distorting the endometrium

          -  Sperm extracted from surgical procedures (i.e. PESA, TESE).

          -  Patients refuse to continue participating in the study.

          -  Patients injected with wrong dose of gonadotropins during the treatment.

          -  Serious complications or accidents arise forcing the patients to discontinue the
             treatments.

          -  Ovarian surgery

          -  Previous chemotherapy or pelvic irradiation
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed consent, demonstrating that the patient understands the procedures
             required for the study and the purpose of the study

          2. Male or female patients of any age (interest is given to children to compare with
             mothers)

          3. Diagnosis of Lyme Disease

        Exclusion Criteria:

          1. Refusal to sign informed consent form

          2. History of bariatric surgery, total colectomy with ileorectal anastomosis or
             proctocolectomy.

          3. Postoperative stoma, ostomy, or ileoanal pouch

          4. Participation in any experimental drug protocol within the past 12 weeks

          5. Treatment with total parenteral nutrition

          6. Any clinically significant evidence of disease that could interfere with the subject's
             ability to enter the trial

          7. Inability to adequately communicate with the investigator or their respective designee
             and/or comply with the requirements of the entire study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Post Covid-19 Cardiopulmonary and Immunological Changes

Eligibility criteria:
Inclusion Criteria:

          -  pcr positive for covid -19 who are survived

        Exclusion Criteria:

          -  dead patient uncooperative
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Total Laparoscopic Hysterectomy vs Minilap Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  Mobile uterus.

          -  Uterine size up to 12 weeks gestation.

          -  Benign lesions.

        Exclusion Criteria:

          -  Enlarged uterus > 12 weeks gestation.

          -  Suspected malignancy.

          -  Large adnexal masses.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient's own account: My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Clinical trial: Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies

Eligibility criteria:
Inclusion Criteria:

          -  Parents with babies with Down Syndrome between 4 and 8 months old.

        Exclusion Criteria:

          -  Parents with babies without Down Syndrome.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)

Eligibility criteria:
Inclusion Criteria:

        - idiopathic RBD (criteria of the international classification of sleep disorders-3)

        For healthy controls : no neurologic or psychiatric disorder

        Exclusion Criteria:

          -  Contraindication to MRI

          -  Do not speak French
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction