Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Neoadjuvant Chomotherapy With Paclitaxel-albumin and S-1 for Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. pathologically diagnosed gastric adenocarcinoma

          2. Type II and III esophageal-gastric-junction malignancy

          3. AJCC stage II-III

          4. No contraindications for surgery, radical resection can be expected

          5. KPS>60; ECOG score:0-2

          6. Expactant survival period>6 months

          7. Age 20~75

          8. No other major health issues

          9. Lab results within 7 days before inclusion must satisfy:

               1. neutrophil≥1.5×109/L

               2. PLT≥100×109/L

               3. hemogloblin≥90g/L

               4. ALT,AST<1.5 upper limit

               5. Tbil≤1.0×UNL

               6. serum creatinine<1.5×UNL

               7. PT-INR/PTT<1.7 upper limit

         10. with measurable lesion according to RECIST1.1 criteria

         11. with consent

         12. co-operative

        Exclusion Criteria:

          1. with other major health issue

          2. allergic to relevant drugs

          3. experienced any other drug therapy with 4 weeks before inclusion

          4. experienced any drug therapy for gastric cancer at anytime

          5. diagnosed with any other malignancy within the past 5 years

          6. women at child-bearing age; pregnant or breast-feeding women

          7. with severe heart disease

          8. with upper GI digestion or disrupted absorption

          9. with peripheral neural disease

         10. with transplated organs or organs having been resected for transplantation

         11. known DPD deficiency

         12. with uncontrolled infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement

Eligibility criteria:
Inclusion Criteria:

          -  Patients eligible for inclusion in the study will have had symptoms for at least 9
             months and have failed conservative management.

        Exclusion Criteria:

          -  Significant prior elbow trauma will be excluded alternative diagnoses that better
             explain their symptoms

          -  Patients who have had significant prior elbow trauma or surgery

          -  WSIB patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in IVF-ET

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing frozen embryo transfer.

        Exclusion Criteria:

          -  Women older than 40 years

          -  Women who have any uterine anomaly or intrauterine pathology such as:

        Endometrial polyp or/ and Large fibroid with a diameter >4 cm

          -  Visible hydrosalpinx on transvaginal ultrasound scans

          -  BMI >35
Female

Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Saphenous Nerve Radiofrequency for Knee Osteoarthritis Trial

Eligibility criteria:
Inclusion Criteria:

          -  Will be included patients older than 18 years, who have moderate to strong chronic
             pain in knee on most of the days days for at least 3 months, with osteoarthritis of
             the knee documented by graded radiologically at 3 to 4 in Kellgren-Lawrence rating,
             refractory to medical treatment (physical therapy, oral analgesics, intra-articular
             injections of hyaluronic acid or corticosteroids).

        Exclusion Criteria:

          -  The exclusion criteria are: acute knee pain, prior surgery on the knee, another
             connective tissue disease affecting the knee, psychiatric or neurological disorders,
             intra-articular injection of hyaluronic acid or corticosteroid for less than 3 months,
             pain related to nerve sciatic, use of anticoagulants and pacemaker.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Analysis of Impact on Nasal Obstruction by Commercially Available Internal Nasal Stents

Eligibility criteria:
Inclusion Criteria:

          -  18 years or older

        Exclusion Criteria:

          -  history of nasal surgery, currently using topical nasal steroid spray, over the
             counter decongestant, history of recurrent epistaxis or history of nosebleed within 2
             weeks prior to data collection, currently pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Electrical Impedance Myography and Ultrasound as Biomarkers of Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion criteria (DMD):

          1. Genetically or histologically established diagnosis of DMD

          2. Male, age 2 - 30

        Inclusion criteria (Control):

        1. Male, age 2 - 30

        Exclusion criteria (DMD):

          1. Presence of implanted pacemaker or other electrical device

          2. Presence of a superimposed neuromuscular or other medical condition that substantially
             impacts the individual's health

        Exclusion criteria (control):

          1. Presence or past history of a neuromuscular disorder or other disease that
             substantially impacts health

          2. Presence of implanted pacemaker or other electrical device.
Male
Accepts Healthy Volunteers
Subject must be at least 2 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Influence of Socioeconomic and Environmental Factors on the Natural History of Idiopathic Pulmonary Fibrosis

Eligibility criteria:
Inclusion Criteria:

          -  Man woman over 18 years old

          -  Certain or probable Idiopathic Pulmonary Fibrosis determined by a multi-disciplinary
             discussion ("ATS / ERS / JRS / ALAT" 2018 criteria)

          -  Idiopathic Pulmonary Fibrosis with a diagnosis of less than 12 months

          -  Signed informed consent

          -  Patient affiliated to a social security scheme or universal health coverage or
             benefiting from state medical aid

        Exclusion Criteria:

          -  Known cause of Diffuse Interstitial Lung Disease (including connectivity,
             Hypersensitivity pneumonitis or pneumoconiosis authenticated)

          -  Patient unable to answer questionnaires

          -  Pregnant or lactating woman

          -  Persons under guardianship
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Development of Outcome-measures for Physically Active Patients With Hip and Groin Pain

Eligibility criteria:
Inclusion Criteria:

          -  Hip and/groin pain more than 6 weeks

          -  Physically active

        Exclusion Criteria:

          -  Systemic diseases

          -  Physically inactive
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Nutritional Risk Factors for Hip Fracture: a Case Control Study

Eligibility criteria:
Inclusion Criteria:

        Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric
        femoral fracture.

        Exclusion Criteria:

          -  Hip fracture as part of multi-trauma or high energy trauma (defined as a fall from a
             higher level than 1 metre). One recent fracture in addition to the hip fracture (e.g.
             radius or shoulder) is acceptable.

          -  Regarded as moribund at admittance.

          -  Absence of a valid informed consent or assent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  age 18 years or older

          -  diagnosis of GERD established by either

               -  24-h oesophageal pH monitoring (performed off medications) showing an abnormal
                  OAE (pH < 4 at least 4% of time) and/or

               -  an upper gastrointestinal (GI) endoscopy showing oesophagitis grade A or B in Los
                  Angeles (LA) classification

          -  presence of typical symptoms of GERD (heartburn and ⁄or regurgitation with at least
             three episodes of typical symptoms per week in the absence of PPI therapy),

          -  adequate symptom relief obtained with PPIs,but needing maintenance with at least
             standard dose.

        Exclusion Criteria:

          -  presence of Barrett's oesophagus >3 cm and ⁄or with dysplasia and ⁄or previously
             treated,

          -  presence of hiatus hernia >3 cm,

          -  presence of oesophagitis grade C or D in LA classification,

          -  presence of oesophageal stricture or achalasia,

          -  history of oesophageal or gastric surgery,

          -  presence of gastric or oesophageal varices,

          -  impossibility to stop an anticoagulant therapy or severe coagulopathy,

          -  any contraindication to general anaesthesia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction