Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Knee Usual Care Evaluation Study

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than 30 years and less than 80 years

          -  Knee pain for at least 6 weeks

          -  Pain rate greater than or equal to 4/10 on a visual analog scale

          -  Morning stiffness less than 30 minutes

          -  Crepitus on active motion of the knee, bony tenderness, or bony enlargement of the
             knee

          -  Willing and able to consider all medical treatment options used to manage
             osteoarthritis of the knee

          -  No contraindications to knee radiographs or MRI

          -  Willing to participate in a registry

          -  Able to understand and sign a consent

          -  Able to answer registry questions independently

        Exclusion Criteria:

          -  Diagnosis of a systemic rheumatic disease or crystalline arthritis (ie RA, SLE,
             systemic sclerosis, psoriatic arthritis or psoriasis, gout, pseudogout, lyme
             arthritis, reactive arthritis, viral arthritis

          -  pregnant or nursing

          -  unable to give informed consent

          -  contraindication to MRI such as indwelling paemaker or cochlear implant

          -  requirement of metal equipment (such as oxygen)

          -  known claustrophobia

          -  gadolinium allergy

          -  lack of fluency in English. Unfortunately, we do not have the financial resources to
             offer full translation services
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment