Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Camostat With Bicalutamide for COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  >= 60 years of age

          -  COVID-19 infection, confirmed by polymerase chain reaction (PCR) test <=5 days from
             enrollment done in the ambulatory setting

          -  Able to provide informed consent

          -  Symptom related to COVID-19. This includes: fever or chills, cough, shortness of
             breath or difficulty breathing, fatigue, muscle or body aches, headache, new loss of
             taste or smell, sore throat, congestion or runny nose, nausea or vomiting, diarrhea or
             other symptom recognized by the Centers for Disease Control to be a symptom of
             COVID-19.

        Exclusion Criteria:

          -  Patients who undergo asymptomatic screening test that is positive and remain
             asymptomatic during the eligible time window

          -  Patients who have had one or more positive more than 5 days prior to enrollment but
             within 60 days of enrollment (ex. if a patient has a positive test 10 days prior to
             enrollment and then a second positive test the day referred for enrollment, that
             patient would be excluded. If a patient had a positive test 5 months ago, and then
             another positive test the day he/she was referred for enrollment, that patient would
             be eligible)

          -  Unable to take oral medication

          -  Male patients with female partners of reproductive potential who are unable to
             maintain effective contraception during the recommended time period (during treatment
             and for 130 days after the final dose)

          -  Symptoms requiring hospitalization or immediate referral to hospital

          -  Taking bicalutamide, any systemic hormonal therapy, or camostat within one month of
             study entry

          -  Known hypersensitivity to bicalutamide, or camostat, or its components.

          -  On coumadin anticoagulation (because of drug-drug interaction with bicalutamide)

          -  Self-reported past medical history of chronic liver disease or cirrhosis

          -  Self-reported myocardial infarction within 6 months or past medical history of
             congestive heart failure with known ejection fraction < 40%

          -  Taking any other investigational treatment for COVID-19 or COVID-19 prophylaxis
             (COVID-19 vaccines and treatments allowed under FDA Emergency Use Authorization are
             allowed.)

        Women and people from all ethnic and race groups are eligible for this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Entailment