Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: CARDIOSPACE Evaluation in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Age : 18 to 40 years

          -  Size : 160 à 180

          -  Weight : BMI between 18 and 24

          -  Medical history :

               -  No history of cardiovascular disease

               -  No chronic treatment

               -  No syncopal events (>2 by year)

          -  Physical examination

               -  Normal cardio-pulmonary ausculation

               -  Normal (DBP [60 - 90] SBP [100 - 140]

               -  Normal heart rate (between 50 and 80 at rest)

          -  Complementary examination

               -  Normal Electrocardiogram

               -  Presence of temporal acoustic window

          -  Capable to understand the objectives and constraints of this study

          -  Covered by health social insurance

          -  Have signed the informed consent

        Exclusion Criteria:

          -  Pregnant woman (beta HCG by urinary test) or breastfeeding

               -  Refusing to sign the informed consent

               -  Don't understand the objectives of this study

               -  Minors or majors protect by the law

               -  Don't Benefit of social insurance

               -  Participation at the time of study enrolment during the present trial period in
                  another clinical trial investigating.

               -  Having reached or surpassed the annual amount of compensation allowed by clinical
                  trials

               -  Receipt of any chronic and regular treatment

               -  Presence of sign cardiovascular diseases during the questioning

               -  Presence of sign cardiovascular diseases during the examination

               -  Presence of sign syncopals events ATCD diseases during the questioning (>2 by
                  year)

               -  Absence of temporal acoustic window with the Transcranial Doppler

               -  Respiratory disorder, asthma

               -  Any troubles preventing the realization of physical activity
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment