Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Luxembourg Cohort of Positive Patients for COVID-19: a Stratification Study to Predict Patient Prognosis

Eligibility criteria:
Inclusion Criteria:

          -  SARS-CoV-2 infection as determined by PCR, performed by one of the certified
             laboratories in Luxembourg

          -  Signed informed consent form

          -  Age ≥18 years old

          -  Hospitalized or at home

        Exclusion Criteria:

          -  Patients not understanding French or German

          -  Patients already included in an interventional study on Covid-19 (Discovery or other)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of ALS and

          -  A confirmed COVID-19 infection determined by:

               1. positive SARS-CoV-2 viral RNA PCR test and/or

               2. positive serology antibody testing for SARS-CoV-2

        Exclusion Criteria:

          -  No ALS diagnosis

          -  No confirmed COVID-19 infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study v1.0

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Identification of the Sick Patient in the ED

Eligibility criteria:
Inclusion Criteria:

          -  Presenting to Royal Preston Hospital Emergency Department

        Exclusion Criteria:

          -  Trauma, purely psychiatric or obstetric presentation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Short Infusion Versus Prolonged Infusion of Ceftolozane-tazobactam Among Patients With Ventilator Associated-pneumonia

Eligibility criteria:
inclusion criteria

          -  patients with ventilator associated-pneumonia to Pseudomonas aeruginosa

          -  patients hospitalized in intensive care units

          -  Pseudomonas aeruginosa susceptible to ceftolozane-tazobactam

          -  Simplified Acute Physiological Score II (SAPS II () > 20

          -  Expected duration of survival > 7 days

          -  Informed consent of the patient or, failing that, the patient's close or trustworthy
             person

          -  Affiliated to a social security scheme or equivalent

        Non inclusion criteria:

          -  history of allergy to one of the two molecules

          -  history of allergy to betalactamines

          -  Strain Isolated resistant to Ceftolozane-Tazobactam combination

          -  Renal insufficiency with a glomerular filtration rate evaluated by Chronic Kidney
             Disease Epidemiology Collaboration (CKD-EPI) < 50 ml/min

          -  Patient on dialysis or under continuous hemodiafiltration

          -  pregnant or nursing women

          -  patient benefiting from a system of legal protection for adults

          -  patient with active immunodepression.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Immunologic Reaction to Polypropylene Mesh in Inguinal Hernioplasty

Eligibility criteria:
Inclusion Criteria:

          -  All patients affected by primary inguinal hernia

        Exclusion Criteria:

          -  Diabetes

          -  Corticosteroids treatment

          -  Immunosuppressive drugs

          -  Cirrhotic patients

          -  Chronic inflammatory disease

          -  Neoplastic patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Hospitalary Chronic Obstructive Pulmonary Disease Registry

Eligibility criteria:
Inclusion Criteria:

          -  Patients older than 40 years with a chronic obstructive pulmonary disease diagnosis
             according to global obstructive lung Global initiative for chronic Obstructive Lung
             Disease criteria.

          -  Follow up at the Hospital Italiano de Buenos Aires.

        Exclusion Criteria:

          -  Refusal to participate or to agree to the informed consent.

          -  Known non chronic obstructive pulmonary disease respiratory disease (ej: Lung Cancer,
             Tuberculosis, Pulmonary Fibrosis, Neumoconiosis, Cystic Fibrosis, Sarcoidosis, etc)

          -  Severe alpha-1 antitripsin deficit (typr SZ or ZZ)

          -  Previously thoracic surgery (ej: lung volume reduction, lung transplantation).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Experience of an Emergency Intensive Care Unit During COVID-19 Pandemic

Eligibility criteria:
Inclusion Criteria:

          -  All patients who followed up in emergency department ICU with the diagnosis of
             COVID-19

          -  Accepted to participate with an informed consent

        Exclusion Criteria:

          -  Patients under the age of 18 or more than 50 years

          -  declined to participate

          -  deaths caused by other than COVID-19
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study to Evaluate Rituximab and Bortezomib in Patients With Newly Diagnosed Acquired Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Must be ≥ 18 years;

          2. Understand and voluntarily sign an ICD prior to any study related
             assessments/procedures are conducted;

          3. Diagnosis of acquired hemophilia A；

          4. acute bleeding episodes(≥once).

        Exclusion Criteria:

          1. Uncontrolled systemic infection;

          2. Allergy to rituximab;

          3. Positive for Lupus anticoagulant;

          4. Life expectancy < 3 months;

          5. Pregnant and breastfeeding women;

          6. Neuropathy>Grade 1;

          7. Positive for Hepatitis B surface antigen or hepatitis C antibody or human
             immunodeficiency virus（HIV）antibody;

          8. Patients with poor compliance；

          9. Patient who is considered by the investigator not suitable for clinical study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Relationship Between the Menstrual Cycle and Heart Disease in Women

Eligibility criteria:
Inclusion Criteria:

          -  Normal menstrual cycles of 25-35 days in length for at least previous 3 cycles

          -  21-40 years of age

          -  BMI > 18, < 30

          -  Serum P4 > 9 ng/ml on single sample collected between days 18-25 of self-reported
             menstrual cycle

          -  Flexible schedule allowing morning blood draws on less than 48 hour notice

          -  In good general health

          -  Commit to remain on stable diet during study period (no changes to normal dietary
             habits)

          -  Commit to using non-hormonal contraceptive methods during study period except those
             prescribed in the experimental protocol

          -  No objections to taking study drugs

        Exclusion Criteria:

          -  Oral contraceptive use or other hormone supplement within the preceding 2 months

          -  Long-acting hormonal contraceptive use in the past 12 months (e.g., Depo-Provera®)

          -  Contraindications to study drugs

          -  Current or past pregnancy within the previous 6 months or currently trying to conceive

          -  Desiring to conceive in the next 8 months

          -  Breastfeeding in the past 2 months

          -  Diagnosed Diabetes or Metabolic Syndrome

          -  Current or previous use of cholesterol lowering drugs within the preceding 12 months

          -  Diagnosed Polycystic Ovary Syndrome

          -  History of, or self-reported, substance abuse

          -  Smoker

          -  Previous infertility treatment excluding male factor issues

          -  Use of an investigational drug within the past 2 months
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment