Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Clinical and Genetic Study of Familial Sarcoidosis (SARCFAM)

Eligibility criteria:
Inclusion Criteria:

          -  patient affected by sarcoidosis, as defined by clinical criteria such as : chest X-ray
             staging, pulmonary function tests, biological variables: serum calcium and creatinine,
             bronchial alveolar lavage cell count and when available, an histological confirmation
             of the granuloma by biopsy. The disease may be expressed initially as uveitis,
             cutaneous or other anatomical sites involvement, which must be also confirmed as
             sarcoidosis-related granuloma by competent pathologists.

        Exclusion Criteria:

          -  Any other disease suggesting sarcoidosis and expressed by similar symptoms, as for ex.
             hilar lymphadenopathy, other forms of uveitis, restrictive pulmonary syndromes .. etc
             ….

          -  Any patients for which the follow-up was not available over the 8 year program of the
             GSF SARCFAM

          -  age < 8 years old or > 80 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Coronavirus (COVID-19) Outcomes Registries in Immunocompromised Individuals Australia (CORIA)

Eligibility criteria:
Inclusion Criteria:

          1. Presenting (in person or via telemedicine) for evaluation because they:

               -  Have clinical symptoms consistent with for COVID-19:

               -  Fever (≥ 37.8 °C) on examination OR patient reported fever (≥ 37.8 °C) or
                  feverishness (felt febrile but did not take temperature) OR any of, cough, sore
                  throat, shortness of breath, rhinorrhoea, headache, chills, generalise myalgia,
                  malaise, fatigue, confusion, diarrhea, nausea or vomiting

               -  Have been contacted because they have been identified as a contact to a confirmed
                  case

               -  Have been contacted and told they tested positive for COVID-19

          2. Have one of the following conditions affecting immune function:

               -  Known or suspected primary immunodeficiency, defined as a predisposition to
                  infection associated with an apparent or presumed deficit of immune function

               -  On immunosuppressive therapy

               -  Treatment with immune checkpoint inhibitors within 36 months of enrolment date

               -  HIV infection

               -  Diagnosis of cancer within 36 months of enrolment date, excluding superficial
                  basal cell and squamous cell carcinomas

               -  Solid organ transplantation

          3. For optional biobanking only, ability to provide informed consent

        Exclusion Criteria:

          -  Nil
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Pleural Manometry in Thoracocentesis

Eligibility criteria:
Inclusion Criteria:

          1. age between 18 and 85 years,

          2. pleural effusion occupying at least one-third of the ipsilateral hemithorax in P-A
             chest radiograph (CXR)

          3. no contraindications for therapeutic thoracentesis

          4. general health condition allowing prolonged procedure of therapeutic thoracentesis.

        Exclusion Criteria:

          -  patients with very small amounts of pleural effusion

          -  patients on mechanical ventilation

          -  patients using anticoagulant therapy

          -  patients refusing to be subjected to thoracocentesis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Efficacy Study of Amazing Me Program

Eligibility criteria:
Inclusion Criteria:

          -  Educators teaching 4th and 5th graders. Thus students will be on average between 9 and
             11 years old.

        Exclusion Criteria:

          -  None.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Behavior, Environment And Treatments for Covid-19

Eligibility criteria:
Inclusion Criteria:

          -  People who are feeling sick and have tested positive for COVID-19

          -  People who are feeling sick but have not tested positive for COVID-19

          -  People who are not feeling sick but want to participate

        Exclusion Criteria:

        • People who are unwilling or unable to provide informed consent
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Efficacy and Safety of a Single Dose of Canakinumab (ACZ885) in Hospitalized Patients With Acute Gout

Eligibility criteria:
Inclusion Criteria:

          -  score over 50 on the 0-100 VAS pain scale

          -  acute, confirmed gout flare for no longer than 3 days

        Exclusion Criteria:

          -  Treatment with biological anti-tumor necrosis factor (anti-TNF) within the past 3
             months

          -  Anti-inflammatory medication for the treatment of acute gout within the previous 24
             hours

          -  Pregnant or breastfeeding women

          -  Major surgery with high infection risk

          -  History of severe allergy to food or drugs

          -  History or risk of tuberculosis

          -  Active infection

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Lessons Learned: the Outcome of TOMEKA® Project is to Teach

Eligibility criteria:
Inclusion Criteria:

          -  Fulfill Inclusion criteria and accept

          -  COVID-19 patients confirmed

          -  be regular on appointments

        Exclusion Criteria:

          -  COVID-19 suspected clinically

          -  Children

          -  refuse to participate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Impact of Menstrual Cycle on Antiretroviral Pharmacokinetics in Healthy Women

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, HIV negative, nonsmoking females between 21 and 40 years of age.

          -  Subjects must be within 20% of their ideal body weight and have a regular menstrual
             cycle, defined as at least 10 cycles per year occurring approximately every 28 ± 4
             days and cycle length varying by not more than 7 days.

          -  Subjects must be willing and able to provide written informed consent.

          -  Subjects cannot be breast feeding, pregnant or be taking hormonal contraception within
             3 months prior to study enrollment. However, they must agree to use an effective
             non-hormonal method of contraception during the study.

        Exclusion Criteria:

          -  Subjects receiving prescription or over-the-counter products which may interact with
             the study medication will be excluded from the study.

          -  Subjects with a Grade 3 or higher laboratory liver, renal or hematology abnormality as
             specified below in accordance with the DAIDS Table for Grading the Severity of Adult
             and Pediatric Adverse Events (DAIDS AE Grading Table) Version 1.0, Dec 2004, will be
             excluded.
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: New Approach for Treatment of Behavioral Disorders in Alzheimer's Disease (Alzheimer's Behavioral and Cognitive Disorders)

Eligibility criteria:
Inclusion Criteria:

          -  Person with Alzheimer's disease.

        Exclusion Criteria:

          -  Bedridden patients.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Gynecomastia Extension Study

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must have entered Trial 1033US/0006 and completed 6 months of treatment and
             one month of follow-up.

          -  Subjects must have gynecomastia, with one breast measuring at least 3 cm in diameter.

        Exclusion Criteria:

          -  Subjects who have been given medications known to cause gynecomastia within the
             previous 3 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 11 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Malignant pleural effusion diagnosed by pleural fluid cytology and / or pleural
             biopsy;

          -  Recurrent pleural effusion (new accumulation of fluid after puncture) and symptoms
             (dyspnea and / or chest pain);

          -  Complete lung expansion (> 90%) after puncture emptying confirmed by chest
             radiography;

          -  Karnofsky index (KPS - Karnofsky Performance Status) > 30;

          -  Agreed to participate in the study and sign an informed consent.

        Exclusion Criteria:

          -  Thrombocytopenia or coagulation disorders (prothrombin activity <50% and platelet
             count <80,000 mm3);

          -  Endobronchial obstruction by the neoplasm;

          -  Major pulmonary fibrosis or lymphangitis carcinomatosis ipsilateral to the effusion;

          -  Volume drained <800 mL;

          -  No contact between the pleural surfaces after draining;

          -  Pleural or active systemic infection;

          -  Massive neoplastic infiltration of the skin;

          -  Inability to understand the quality of life questionnaire;

          -  Age less than 18 years;

          -  Previous pleural procedures (except punctures and needle biopsies).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment