Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluation Of Acceptability And Satisfaction Of Hemophilia Patients Treated With FusENGO

Eligibility criteria:
Inclusion Criteria:

          -  Male adults (aged 18 to 65 years) with Haemophilia A (all severity levels) who
             currently use FVIII treatment either prophylactically or on-demand using traditional
             factor VIII delivery mechanisms.

          -  Patients advised for any reason by their physician to switch to a new factor VIII
             delivery device, namely FuseNGO, before receiving any details about this study or
             Patients who requested to be treated with a new factor VIII delivery device namely
             FuseNGO, before receiving any details about this study.

        Exclusion Criteria:

          -  Patients not previously recommended by their physician to switch to this new factor
             VIII delivery system or Patients who did not previously ask their physician to be
             switched to this new factor VIII delivery system.

          -  Patients for which it is anticipated that 10 infusions will not occur in the 12 months
             following their inclusion in the study.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea

Eligibility criteria:
Inclusion Criteria:

        -Moderate to severe persistent facial erythema associated with rosacea.

        Exclusion Criteria:

          -  Greater than 3 inflammatory lesions on the face

          -  Current treatment with monoamine oxidase (MAO) inhibitors

          -  Raynaud's syndrome, narrow angle glaucoma, orthostatic hypotension, scleroderma or
             Sjogren's syndrome.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Memory and Insulin in Early Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Early Alzheimer's disease

        Exclusion Criteria:

          -  Patients with Late Alzheimer's disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, non smoker, men and nonpregnant nonlactating women

          -  Weighing a minimum of 60 kg and were within 15% of ideal weight for height as
             described in the Metropolitan Life Insurance Height and Weight Standards

          -  Who did not have a history or show presence of drug or alcohol dependence or abuse

          -  And who had, after sitting for 5 minutes, blood pressure between the ranges of 100 to
             150 mm Hg systolic and 50 to 90 mm Hg diastolic. Any decrease in systolic blood
             pressure after standing for 2 minutes had to be less than or equal to 20 mm Hg

        Exclusion Criteria:

          -  History of chronic obstructive pulmonary disease or any other lung disease, such as
             asthma, that would cause carbon dioxide retention

          -  Known allergy or hypersensitivity to fentanyl or other opioids, naltrexone or naloxone

          -  Usage of prescription medication (except for birth control medications, sex-hormone
             replacement or vitamins) within 14 days before Day 1, monoamine oxide inhibitors
             within 21 days prior to Day 1, over-the-counter medication (except for vitamin
             supplements or acetaminophen less than 2 gm/day) or herbal medication within 3 days
             prior to Day 1, alcohol, grapefruit juice, or caffeine within 48 hours before dosing

          -  Consumption of more than 450 mg of caffeine per day (eg, approximately 5 cups of tea,
             3 cups of regular coffee, or 8 cans of cola)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Probiotics in Metformin Intolerant Patients With Type 2 Diabetes

Eligibility criteria:
Inclusion Criteria:

          1. Written informed consent for participation in the clinical trial

          2. Age 18-75 years

          3. Type 2 diabetes mellitus diagnosed at minimum 6 months prior to the study

          4. Metformin intolerance defined as gastrointestinal adverse effects occurrence at the
             daily metformin dose higher than 1500 mg assessed by the Questionnaire adapted from
             Laura J. McCreight et al., which disappeared or decreased to the accepted tolerable
             level after dose reduction to 1500 mg per day.

          5. Metformin treatment in the daily dose not higher than 1500 mg

          6. Stable metformin dose in the last 3 months before inclusion to the study

        Exclusion Criteria:

          1. Estimated Glomerular Filtration Rate (eGFR) < 60 ml /min/ 1.73m2

          2. Elevation of ALT and aspartate aminotransferase (AST) activity in the blood serum,
             three times above the reference value

          3. Chronic bowel disease

          4. Any other acute or chronic disease that may cause gastrointestinal symptoms

          5. Acute or chronic pancreatitis

          6. Chronic alcohol consumption >30 g/day for men and > 20 g/day for women

          7. Antibiotic therapy in the last 6 months prior to the study

          8. Probiotics use in the last 3 months before the study

          9. Chronic use of steroid drugs or other immunomodulators

         10. Heart failure (New York Heart Association (NYHA) III and IV)

         11. Pregnancy or breast feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Intraarticular Ozone Therapy for Pain Control in Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

        - Osteoarthritis of knee

        Exclusion Criteria:

          -  Positive rheumatologic serologic tests

          -  Cognitive impairment

          -  Adjacent osteomyelitis

          -  Bacteremia

          -  Hemarthrosis

          -  Impending (scheduled within days) joint replacement surgery

          -  Infectious arthritis

          -  Joint prosthesis

          -  Osteochondral fracture

          -  Periarticular cellulitis

          -  Poorly controlled diabetes mellitus

          -  Uncontrolled bleeding disorder or coagulopathy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Alveolar Management Following Teeth Extraction

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Indication for tooth extraction resulting in a edentulous gap

          -  Male and female patients with an age range 20-60 years

          -  Caucasian

          -  For female patients: a negative pregnancy test

          -  Normotonic blood pressure (according to the WHO definition):

               -  Men: 110/70 - 140/90 mm Hg

               -  Women: 100/60- 140/90mm Hg

        Exclusion Criteria:

          -  Parallel implantation of another implant

          -  Parallel planned prosthetic restoration of the adjacent teeth

          -  Smoker (less than 5 years non-smoker)

          -  Nursing women

          -  Participation in another clinical trial which dates back to less than 3 months before
             inclusion in this clinical trial

          -  Intake of bisphosphonates

          -  Radiation therapy (medical history or current)

          -  Known Diabetes mellitus

          -  Inflammatory processes in the mouth (PSI> 2)

          -  Presence of autoimmune diseases (Rheumatoid arthritis, Sjögren's syndrome, Systemic
             lupus erythematosus)

          -  Presence of blood coagulation disorders (Haemophilia A/B), or the intake of
             anticoagulants (Warfarin, new oral anticoagulants, aspirin> 100 mg)

          -  Osteogenesis imperfecta

          -  Osteoporosis

          -  Leukemia

          -  Agranulocytosis

          -  Immunocompromised patients

          -  Acute phase and rehabilitation phase of myocardial infarction

          -  Oncogenes diseases

          -  Patients undergoing chemotherapy

          -  Sepsis

          -  Acute and chronic infections: sinusitis, rhinitis, pharyngitis and Otitis media

          -  Wound healing disorders

          -  Seizures

          -  Gingival hyperplasia

          -  Alcohol abuse

          -  Drug abuse

          -  Infectious diseases (HIV, Hepatitis B and C)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Phase 2a Study of AR882 Alone and in Combination With Febuxostat or Allopurinol in Gout Patients

Eligibility criteria:
Key Inclusion Criteria:

          -  History of gout

          -  sUA > 7 mg/dL

          -  Estimated Glomerular Filtration Rate (eGFR) ≥ 60 mL/min/1.73m2

        Key Exclusion Criteria:

          -  Malignancy within 5 years, except for successfully treated basal or squamous cell
             carcinoma of the skin

          -  History of cardiac abnormalities

          -  Active peptic ulcer disease or active liver disease

          -  History of kidney stones

          -  Allergy or intolerance to colchicine, febuxostat, and allopurinol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Chronic Postoperative Pain After Laparoscopic Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

        All laparoscopic TEP and TAPP repairs that have been registered in the SHR from September
        1, 2012, until November 6, 2019.

        Exclusion Criteria:

          -  Open repairs.

          -  Hernioplasties that were converted from laparoscopic to open surgery.

          -  Age < 15 years.

          -  Patients not having a 10-digit state-assigned Patient Identification Number.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Treatment of Dilated Blood Vessels on the Cheeks With a New Yellow Laser and a Traditional Green Laser

Eligibility criteria:
Inclusion Criteria:

          -  The subjects are required to be Finnish speaking adults with symmetrical facial
             telangiectasia, volunteering to participate in the clinical trial.

          -  The subjects have to have a Fitzpatrick skin phototype I-IV.

        Exclusion Criteria:

          -  pregnancy

          -  lactation

          -  hemophilic condition

          -  Fitzpatrick skin phototype V-VI

          -  drug or alcohol abuse

          -  subjects who are under guardianship

          -  subjects with significant tanning less than 6 weeks prior to the treatment day.

          -  unbalanced basic diseases, such as diabetes, heart disease, cancer etc.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment