Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH)

Eligibility criteria:
Inclusion Criteria:

          -  For both operation and control groups, women were eligible for inclusion if they had
             regular menstrual cycles and no history of pelvic surgery.

        Exclusion Criteria:

          -  No endocrine disorders (e.g. PCOS).

          -  Received any kind of medication that could affect the results within the preceding 6
             months.

          -  Any woman who had a suspected pathologic lesion in the ovary or menopausal symptoms.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Prophylaxis Versus on Demand Treatment for Children With Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged 2-16yrs

          -  Severe hemophilia A (<1% FVIII:C [Blood Clotting Factor VIII:C] )

          -  Minimum of at least 50 documented ED (exposure day) prior to enrolment

          -  No measurable inhibitor activity at baseline and history of FVIII inhibitor antibody
             formation

          -  Parents or legal guardians document, sign, and date informed consent

        Exclusion Criteria:

          -  Another bleeding disease that is different from hemophilia A

          -  Known hypersensitivity to the active substance, mouse or hamster protein

          -  Thrombocytopenia (platelet count <100 000/mm3) based on previous medical records
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Velocimetric Study of Temporal Arteries in Patients With Horton Disease Using Scan-Doppler

Eligibility criteria:
Inclusion Criteria:

          -  patients with suspicious giant arteritis

        Exclusion Criteria:

          -  patients who have already been treated or diagnosed for giant arteritis
No condition on gender to be admitted to the trial.

Subject must be at least 55 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Anti-Müllerian Hormone (AMH) Measured With Fully Automated Assay Versus AFC in the Prediction of Ovarian Response

Eligibility criteria:
Inclusion Criteria:

        BMI between 18 and 30 kg/m2, basal serum day 3 FSH ≤ 15 IU/l, normal regular menstrual
        cycles, ranging from 25 to 33 days in length, normal thyroid-stimulating hormone (TSH) and
        prolactin levels, normal uterine cavity as assessed by hysteroscopy or sonohysterography or
        three-dimensional ultrasound and presence of both ovaries.

        Exclusion Criteria:

        irregular menstrual cycles, severe endometriosis, defined as stage III-IV of the American
        Society for Reproductive Medicine (ASRM) revised classification, previous ovarian surgery,
        presence of ovarian cysts, polycystic ovary syndrome, use of hormonal contraception in the
        previous 3 months and use of gonadotrophins in the previous 3 months, any known metabolic
        or endocrinological disease
Female

Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Aged 5-12 years

          -  Clinical manifestation, enzymology, electromyogram, gene type confirmed the diagnose
             of Duchenne muscular dystrophy

          -  Sign the consent form and follow the clinic trail procedure

        Exclusion Criteria:

          -  Not Duchenne muscular dystrophy

          -  Any history of hypersensitivity to serum products,or other know drug and food allergy

          -  Combined Pneumonia or other Severe systemic bacteria infection

          -  HIV+, TPPA +， patients diagnosed as HBV or HCV

          -  Tumor Markers +

          -  Severe psychotic patients, cognitive dysfunction

          -  Coagulation disorders

          -  Uncontrolled hypertension after treatment，blood pressure≥180mmHg/110 mmHg

          -  Other severe systemic or organic disease

          -  Enrollment in other trials in the last 3 months

          -  Received any stem cell therapy in past 6 months

          -  Other criteria that investigator consider improper for inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Misoprostol for Second Trimester Pregnancy Termination

Eligibility criteria:
Inclusion Criteria:

          -  Pregnancy 13-24 weeks.

          -  Women with indication for termination of the pregnancy due to intra uterine fetal
             death

        Exclusion Criteria:-Pregnancy before 13 weeks.

          -  Pregnancy beyond 24 weeks.

          -  Women with scared uterus.

          -  Known hypersensitivity for misoprostol.

          -  Refusal of the woman to participate.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial II

Eligibility criteria:
Inclusion Criteria:

          -  Males or females in generally good health at least 40 years of age

          -  Osteoarthritis (OA) of at least one knee, verified by a weight-bearing radiograph

          -  Subject has taken an oral NSAID or analgesic at least 3 days during the past 30 days
             to treat knee OA pain

        Exclusion Criteria:

          -  Females who are pregnant or lactating or who may become pregnant

          -  Hypersensitivity (exacerbations of asthma, rhinitis, or urticaria) to sulfonamides,
             acetaminophen, diclofenac, celecoxib, aspirin, or any other NSAID

          -  History of myocardial infarction, congestive heart failure, stroke, coronary-artery
             bypass graft surgery, or any other significant cardiovascular disease, or is on any
             form of anticoagulation therapy other than low-dose aspirin (no more than 325 mg/day)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: The Effects of Potassium Citrate on Bone Metabolism

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women, more than 2 years post menopause

          -  Osteopenia, defined as a T score at the lumbar spine or total hip between -1.0 and
             -2.5

          -  No history of prior fragility fracture

        Exclusion criteria:

          -  Renal insufficiency

          -  Use of potassium sparing diuretics

          -  Use of potassium supplements

          -  Hyperkalemia

          -  Secondary causes of osteoporosis or metabolic bone disease

          -  Delayed gastric emptying

          -  esophageal compression, intestinal obstruction or stricture

          -  use of anticholinergic medication

          -  active urinary tract infection.
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity

Eligibility criteria:
Inclusion Criteria:

          -  Primary Sjögren's syndrome according to the American-European Consensus Criteria)

          -  Informed and having signed the study consent form

        Exclusion Criteria:

          -  Secondary Sjögren's syndrome

          -  Other systemic autoimmune disease (e.g. rheumatoid arthritis, AntiNeutrophil
             Antibodies (ANCA) -associated vasculitis, mixed connective tissue disease…)

          -  Incapacity or refusal to sign the informed consent form

          -  Incapacity or refusal to perform the follow-up examinations required by the study

          -  Has received abatacept, sifalimumab, rontalizumab, anifrolumab, belimumab, Tumor
             Necrosis Factor (TNF) antagonists or interferon during the 6 months prior to the
             inclusion

          -  Has any current signs or symptoms of active infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Adaptation Among Adolescents and Adults With Klinefelter Syndrome

Eligibility criteria:
-  INCLUSION CRITERIA:

               1. Must have Klinefelter syndrome (47,XXY) by self-report.

               2. Must be 14 years or older.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population

Eligibility criteria:
Inclusion Criteria:

          -  Patient over 18 years old;

          -  Diagnosis of fovea plana in one or both eyes, confirmed by two ophthalmologists
             blinded to each other from OCT-B imaging;

        Exclusion Criteria:

          -  Known Albinism

          -  Known family history of albinism

          -  History of eye surgery other than cataract

          -  Alteration of macular visual function (loss of visual acuity independent of a disorder
             of the environments, central scotoma, metamorphopsies, etc.)

          -  Presence of another anomaly in OCT in addition to the fovea plana (epiretinal
             membrane, damage to the external retina, etc.)

          -  Syndromic fovea plana

          -  Pregnant or breastfeeding woman
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction