Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Turkish Acquired Haemophilia Registry

Eligibility criteria:
Inclusion Criteria:

          -  Acquired haemophilia diagnosis, written consent

        Exclusion Criteria:

          -  Being unable to give written consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone

Eligibility criteria:
Inclusion Criteria:

          -  Female volunteers in early to mid-puberty (i.e., late Tanner I [estradiol level > 20
             pg/mL], Tanner II, or Tanner III)

          -  Premenarcheal

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin less than 12 g/dl and hematocrit less than 36%

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism, reflected by persistently abnormal
             thyroid-stimulating hormone (TSH) values

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-hydroxyprogesterone > 200 ng/ml (in girls without a previous
             diagnosis of congenital adrenal hyperplasia)

          -  Dehydroepiandrosterone sulfate (DHEA-S) > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 26 kg.
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Evaluation of Two Types of PRP in Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

        Patients with Osteoarthrits

        Exclusion Criteria:

          -  diabetes, rheumatoid arthritis, axial deviation (varus> 10 degrees valgus> 10
             degrees), blood disorders (coagulopathy and platelet changes), cardiovascular
             diseases, infections, immunosuppression, patients on anticoagulant therapy or
             antiplatelet use of nonsteroidal anti-inflammatory 5 days before blood collection,
             patients with hemoglobin concentrations <11 and platelet count <150,000 mm³.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Study Evaluating the Safety and Efficacy of Autologous Non-Hematopoietic Peripheral Blood Stem Cells in COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  RT-PCR Laboratory confirmation of COVID-19.

          -  Male or female aged ≥ 18 years.

          -  Interstitial lung change ≥ 3 judged by "Lungs Lobar based scoring" according to
             computed tomography (CT) scans.

          -  Hospitalized and symptomatic patients, referring one or more of the following symptoms
             (fever, cough, or shortness of breath), in association with (at least one): tiredness,
             runny nose, headache, sore throat, chills, muscle pain, or new loss of taste or
             smell).

          -  Ability to comply with test requirements and peripheral blood stem cells collection.

          -  The patient or legal representative agrees to participate in the study, and signs the
             SENTAD-COVID Study informed consent form.

        Exclusion Criteria:

          -  Pediatric patients (aged < 18 years).

          -  Diagnosis of any kind of shock.

          -  Organ transplants in the past 3 months.

          -  Patients receiving immunosuppressive therapy.

          -  Diagnostic of Hepatitis B Virus (HBV) infection.

          -  Diagnostic of Human Immunodeficiency Virus (HIV) infection or Acquired
             Immunodeficiency Syndrome (AIDS).

          -  Current diagnosis of cancer.

          -  History of malignancies in the past 5 years.

          -  Pregnant or lactating women.

          -  Have participated in other clinical trials in the past 3 months.

          -  Inability to comply with test requirements and peripheral blood stem cells collection.

          -  Inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Validation Study of Physical Measurement of Tophi

Eligibility criteria:
Inclusion Criteria:

          -  Must have at least 1 palpable gouty tophus nodule in the foot/ankle, hand/wrist, or
             elbow, confirmed as gouty by prior diagnosis according to ACR criteria.

          -  The tophus must be solid, round, non-tender, intact, and larger than 10mm in both
             length and width.

          -  Joints nearest and immediately adjacent to the selected tophus must not be acutely
             inflamed.

          -  Must be on stable treatment for gout with no medication changes in the past 30 days.

        Exclusion Criteria:

          -  Must be able to return to the clinical site within 10 days.

          -  Must not have allergy to ink.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Autologous Human Adipose-Derived Mesenchymal Stem Cells in Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  The patient is diagnosed with later stage of Alzheimer Disease with sever cognitive
             disability.

          -  All current anti-Alzheimer medicines cannot prevent disease progression and the
             patient's mental and physical ability persistently declined

          -  Patient's legal guardian and caregiver must voluntarily sign an approved written
             consent form after ample explanation of the proposed therapy.

        Exclusion Criteria:

          -  Current diagnosis of malignancy

          -  Renal/liver dysfunction: Exceed two times as normal subject

          -  Pregnant or nursing

          -  Received other trial drugs within 30 days after participation of this study

          -  Experienced major surgery or trauma in the last 14 days
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Zinc Sulfate in the Treatment of Rosacea: A Randomized, Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of facial rosacea made or confirmed by one of the investigators.

          -  Severity of signs of rosacea "greater than mild" at the time of enrollment.

        Exclusion Criteria:

          -  Treatment for rosacea during the 3 months prior to enrollment.

          -  Use of zinc dietary supplement > 25 mg per day during the 3 months prior to enrollment
             ( Most patients taking multivitamins with Zinc, often 15 mg per day, will not be
             excluded, whereas most patients taking additional Zinc supplements, often 25-50 mg per
             day or more will be excluded.)

          -  Diagnosis of rosacea fulminancy.

          -  Pregnant or breast feeding.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
             at least three months

          -  Referred normal menses .Use of the same brand of sanitary protection wear for the
             whole of the period.

          -  BMI between 18 and 30

        Exclusion Criteria:

          -  Abnormal Bleeding Score

          -  Positive gynecological history of fibroids, polyps or malignancy

          -  Treatment with anti-coagulants, antifibrinolytics, non steroidal anti-inflammatory
             agents

          -  Use of oral contraceptives in past three months

          -  Use of intrauterine devices (IUDs) in past three months .Hgb levels <12 g/dl and
             Ferritin <25 ng/ml.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: A Clinical Trial to Test the Saftey and Success Rate for a Cerrumen Cleaning Device - "Wondertip".

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 1 year old who have cerumen impaction.

        Exclusion Criteria:

          -  external ear infection

          -  chronic otitis media with perforation of the tympanic membrane

          -  past ear surgery

          -  otorrhea

          -  inflamation of the auricle or the periauricular region

          -  temporal bone neoplasm

          -  deafness in the contralateral ear (single sided deafness).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Inpatient Physical Activity Function Through Enhanced Participation Levels in Animal-Assisted Therapy Programs

Eligibility criteria:
Inclusion Criteria:

          1. Are being rehabilitated as an inpatient for Parkinson's, stroke, or generalized
             weakness deconditioning (muscle weakness);

          2. Are able to give informed consent or communicate either verbally or in writing;

          3. Are able to follow instructions;

          4. Are at least 18 years old; and

          5. Choose to participate.

        Exclusion Criteria:

          1. Have a fear/dislike of dogs;

          2. Show noticeable cues of resistance/discomfort to dogs;

          3. Are allergic to dogs;

          4. Are immunocompromised;

          5. Are not being rehabilitated for Parkinson's, stroke, or generalized weakness
             deconditioning (muscle weakness);

          6. Are not able to give informed consent or communicate either verbally or in writing;

          7. Are not able to follow instructions;

          8. Do not speak English;

          9. Are not at least 18 years old; and

         10. Do not choose to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction