Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Associated Endothelial Dysfunction Study

Eligibility criteria:
Inclusion criteria :

          -  Adult patient (≥ 18 ans)

          -  Affiliation to the French National Healthcare System

          -  Voluntary patient who have given oral consent

        Cohort C1, COVID19 (+) patients hospitalized in ICU :

          -  Patient admitted to ICU within 72 hours before inclusion

          -  Patient presenting SARS-COV2 pneumonia diagnosed by CT scan or by COVID-19 PCR test.

        Cohort C2, COVID19 (-) patients hospitalized in ICU :

          -  Patient admitted to ICU within 72 hours before inclusion

          -  All COVID19 PCR tests carried out in the 15 days prior inclusion are negative

          -  All the CT scans possibly performed since the acute event do not show COVID19
             pulmonary lesions

          -  Matching with the cases C1 COVID 19 (+) patients on sex, age (threshold at 65 years),
             treated hypertension, treated diabetes mellitus.

        Cohort C3, elective surgery patients who are not hospitalized in ICU :

          -  ASA 1 classification (no major comorbidity, a normaly healthy patient)

          -  Asymptomatic to COVID19 according to French Anesthesiology Society 2020 :

               -  No major symptoms among : measured fever > 38°C, dry cough, shortness of breath
                  or high respiratory rate (>20/min), anosmia, ageusia

               -  No more than one minor symptom among : sore throat, rhinorrhea, chest pain,
                  myalgia, general alteration or severe tiredness, confusion, disorientation,
                  headache, diarrhea, nausea or/and vomiting, rash/ frostbite/cracking on fingers
                  or hand

          -  No positive COVID19 PCR test within 15 days prior to inclusion

        Non-inclusion criteria :

          -  Proven sepsis (Procalcitonin >1.0 µg/l) in the 24 hours prior to inclusion

          -  End-stage kidney disease with dialysis

          -  Patient with haemodynamic failure treated by norepinephrine

          -  Patient with traumatic brain injury

          -  Intubated patient and/or sedated

          -  Pregnant woman, parturient and nursing mother

          -  Person restricted in liberty by an administrative or judicial decision

          -  Patient concerned with admission for psychiatric care

          -  Adult person subject to a legal protection measure or unable to express consent

        Exclusion criteria :

        • Cohorts C2 and C3 : positive COVID-19 PCR test within 5 days after inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction