Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Pilot Study of Thalidomide to Treat Sjogren's Syndrome

Eligibility criteria:
Primary Sjogren's Syndrome; symptoms of dry eyes and dry mouth; 6 week period off disease
        modifying agents, such as antimalarials or steroids.

        No males.

        No females with childbearing potential.

        No patients with hypersensitivity to thalidomide.

        No confounding medical illness or abnormal laboratory test that in the judgment of the
        investigators would pose added risk for study participants.
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device

Eligibility criteria:
Inclusion Criteria:

          1. Women with no desire to preserve their fertility who have heavy menstrual bleeding
             without organic pathology (DUB) of more than six months duration

          2. Associated functional disability (negative impact on life quality).

          3. Lack of response to medical treatment.

          4. Prepared to undergo surgical treatment without general anaesthesia

        Exclusion Criteria:

          1. Women under 25 years

          2. Suspected genital tract infection

          3. Uterine pathology including endometrial pathology on endometrial biopsy (e.g.
             endometrial hyperplasia or carcinoma) and structural lesions (e.g. uterine
             malformations, adhesions, polyps, submucous fibroids or extracavity fibroids > 3cm in
             diameter) as identified on pelvic ultrasound and/or outpatient hysteroscopy.

          4. Uterine cavity length >11cm

          5. Adnexal pathology

          6. Previous open myomectomy or endometrial ablation / resection and classical caesarian
             section

          7. Patients considered vulnerable (e.g. current mental illness, emotionally labile,
             learning difficulties, immaturity)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Antireflux Efficacy of Hiatal Hernia Repairs in Sleeve Gastrectomy Patients

Eligibility criteria:
Inclusion Criteria:

          -  All obese patients with a BMI between 35-50

          -  Aged 18-65 and undergoing surgery for a Sleeve Gastrectomy in institution's bariatric
             surgery department

        Exclusion Criteria:

          -  hiatal hernias greater than 2 cm,

          -  hiatal repair requiring mesh placement

          -  prior bariatric surgery or any other counterindication to Sleeve Gastrectomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Open, Randomized, Two Way Crossover 40mg, Orally and Intravenously

Eligibility criteria:
Inclusion Criteria:

          1. Heartburn on at least 2 days of the past 7 days prior to screening, with or without a
             history of EE or a documented diagnosis of GERD within 6 months prior to screening,
             with or without a history of EE.

          2. Body mass index (BMI) of ≥18.5 and ≤35 kg/m2. [BMI will be calculated using the
             following formula: weight (kg)/height (m)2.]

          3. Able to communicate with the investigator and to understand and comply with the
             requirements of the study.

        Exclusion Criteria:

          1. History of esophageal, gastric, or duodenal surgery, except for simple closure of an
             ulcer.

          2. History of severe liver disease, including (but not limited to) cirrhosis and acute or
             chronic hepatitis.

          3. Any significant "alarm symptoms", within the past 6 months, such as, unintentional
             weight loss, gastrointestinal bleeding, jaundice or any other sign indicating serious
             or malignant disease.

          4. Abnormal lab test results, as indicated in the protocol.

          5. Other diseases, as indicated in the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Rigid Thoracoscopy Versus CT-Guided Pleural Needle Biopsy

Eligibility criteria:
Inclusion Criteria:

          1. Ages between 18-85

          2. Pleural effusion in conventional radiography

          3. At least 10x10 cm space in pleural space with effusion

          4. No bleeding diathesis

          5. Informed consent

        Exclusion Criteria:

          1. Patients who went under pleural biopsy before

          2. Arrythmia

          3. Hypertensive attack during biopsy

          4. Bleeding diathesis

          5. Hypoxemia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Intranasal Heparin Tolerability Study

Eligibility criteria:
Inclusion Criteria:

        Normal, healthy adults aged 18 to 65 years

        Exclusion Criteria:

          -  Allergy to Heparin

          -  Currently taking any prescription blood thinners or anti-coagulants, or currently
             taking any intranasal medication

          -  Known history of anemia, thrombocytopenia, or other blood disorder

          -  Autoimmune disorders

          -  Known history of Neurologic/Psychiatric disorders

          -  Report of an active infection

          -  Subject is pregnant or breast-feeding, or is expecting to conceive during the study.

        NOTE: Subjects will be instructed to abstain from alcohol for the duration of the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Valvuloplasty as Alternative to Toupet Fundoplication for GERD

Eligibility criteria:
Inclusion Criteria:

          -  Objectively proven GERD (by gastroscopy and/or 24-hour pH and/or impedance monitoring)

          -  Age ≥18

          -  Written informed consent for study participation

        Exclusion Criteria:

          -  BMI ≥ 30

          -  Hiatal hernia >3cm

          -  Achalasia

          -  Previous gastric surgery

          -  Previous esophageal surgery

          -  Inability to understand the Dutch language

          -  Inability to understand and/or fill in the questionnaires
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Study to Evaluate the Safety and Efficacy of Androxal Treatment in Men With Secondary Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Total serum testosterone concentrations < 300 ng/dL at baseline

        Exclusion Criteria:

          -  Presence or history of prostate cancer

          -  Elevated PSA > 3.5 ng/mL

        Additional inclusion and exclusion criteria may apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 68 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Blinded Dry Mouth Spray Crossover Study

Eligibility criteria:
Inclusion Criteria:

          -  biopsy-proven oral cavity, oropharynx, larynx, and hypopharynx carcinoma

          -  who received primary radiation with curative intent (>50 Gray in 20 fractions)

          -  radiation treatment completed greater than 6 months ago

          -  who endorse xerostomia

        Exclusion Criteria:

          -  evidence of metastasis or recurrent disease

          -  Current use of pilocarpine, antidepressants, anticholinergic drugs, or any other
             medication that has an effect on salivation

          -  those who have documented medical conditions associated with xerostomia such as
             Sjogren's Syndrome

          -  those who use oral inhalants for the treatment of respiratory disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Changes in Bleeding and Clotting During the Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Must be female

          -  Aged 18 to 50 years, with regular menstrual cycles.

          -  Healthy volunteers and women with von Willebrand's disorder are both being recruited.

        Exclusion Criteria:

          -  Pregnancy

          -  Use of hormonal therapy including birth control pills

          -  Use of hemostatic agents such as DDAVP or anti-platelet agents.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment