Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: 5-Alpha Reductase and Anabolic Effects of Testosterone

Eligibility criteria:
Inclusion Criteria:

          -  Age > 60 years males

          -  Primary care at the Malcolm Randall VA Medical Center in Gainesville, Florida.

          -  Consenting subjects who have a morning (between 6:00 AM and 10:00 AM) serum total
             testosterone 300 ng/dL or bioavailable testosterone concentration 70 ng/dL and no
             exclusion criteria will be randomized to receive either testosterone or placebo.

        Exclusion Criteria:

          -  Subjects with cognitive impairment will be identified by the Mini-Cog test and
             excluded. The Mini-Cog has high sensitivity and specificity for cognitive impairment,
             and is not affected by level of education.

          -  We will also exclude subjects with receptive aphasia, or a contraindication to
             testosterone replacement (i.e., history of or active prostate or breast cancer, severe
             benign prostatic hyperplasia as assessed by elevated American Urologic Association
             Symptom Index (AUASI) score > 25), congestive heart failure (Class 3 or 4), sleep
             apnea syndrome, polycythemia (Hct > 55%), or prostate specific antigen (PSA) > 2.6
             ng/mL) will be excluded.

          -  Obese subjects (BMI > 35) will also be excluded.

          -  Subjects currently receiving testosterone supplementation or subjects who have an
             allergy to testosterone will also be excluded.

          -  Subjects previously receiving testosterone replacement therapy must be off such
             medication for at least four weeks.
Male
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effects of Acupuncture on Sjögren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Adults ≥ 18 years old, both genres, who consent to participate of the study

          -  Patients who were diagnosed with SJ according to the criteria of the American College
             of Rheumatology and the European League against Rheumatism

        Exclusion Criteria:

          -  Patients who have undergone head and neck radiation therapy;

          -  Patients with a history of neoplasias and salivary gland infections;

          -  Patients with acquired immunodeficiency virus infection, sarcoidosis, viral hepatitis,
             diabetes mellitus and smokers;

          -  Patients with inability to undergo total saliva collection by established techniques;

          -  Patients who can not attend regular acupuncture sessions;

          -  Patients who had a change in the dosage of medications in use within 6 weeks before
             the start of the study.

          -  Patients who received acupuncture therapy up to 6 weeks prior to the start of the
             study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Effect of Preoperative Inflammation-based Scores on Postoperative Morbidity and Mortality for Laparoscopic Gastrectomy

Eligibility criteria:
Inclusion Criteria:Age from 18 to 75 years

          -  Primary lower third gastric adenocarcinoma (papillary, tubular, mucinous, signet ring
             cell, or poorly differentiated) confirmed pathologically by endoscopic biopsy

          -  cT2-4a, N0-3, M0 at preoperative evaluation according to the American Joint Committee
             on Cancer (AJCC) Cancer Staging Manual Seventh Edition

          -  No distant metastasis is observed. And the spleen, pancreas or other adjacent organs
             are not involved by the tumor.

          -  Performance status of 0 or 1 on Eastern Cooperative Oncology Group scale (ECOG)

          -  American Society of Anesthesiology score (ASA) class I, II, or III

          -  Written informed consent

        Exclusion Criteria:• Women during pregnancy or breast-feeding

          -  Severe mental disorder

          -  History of previous upper abdominal surgery (except laparoscopic cholecystectomy)

          -  History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal
             dissection

          -  Enlarged or bulky regional lymph node envelop important vessels

          -  History of other malignant disease within past five years

          -  History of previous neoadjuvant chemotherapy or radiotherapy

          -  History of unstable angina or myocardial infarction within past six months

          -  History of cerebrovascular accident within past six months

          -  History of continuous systematic administration of corticosteroids within one month

          -  Requirement of simultaneous surgery for other disease

          -  Emergency surgery due to complication (bleeding, obstruction or perforation) caused by
             gastric cancer

          -  FEV1<50% of predicted values
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: The Beneficial Effects of a Protein-rich Breakfast on Appetite Control & Cognition in Overweight and Obese Adolescents

Eligibility criteria:
Inclusion Criteria:

        The participants must meet the following inclusion criteria:

          -  Female

          -  Age range 15-20 y

          -  Overweight to obese (85th -99th percentile for BMI for age; BMI: 25-39.9 kg/m2

          -  No metabolic, psychological, or neurological diseases/conditions

          -  Not currently/previously on a weight loss/other special diet

          -  Frequently eats lunch ( ≥ 5 eating occasions/wk)

          -  Consistently skips breakfast every week day (i.e., 5 week days/week)

          -  Right-handed (necessary for the fMRI analyses)

        Exclusion Criteria:

        The participants will be excluded from participation in the study if they meet the
        following exclusion criteria:

          -  Male

          -  Age >20 y and <15 y

          -  Under Weight (<5th percentile for BMI for age; BMI: <18 kg/m2)

          -  Normal Weight (6th-84th percentile for BMI for age; BMI: 18-24.0 kg/m2)

          -  Morbidly Obese (BMI: >40 kg/m2)

          -  Clinically diagnosed with diabetes (Type I or Type II), having an eating disorder, or
             having any other metabolic, psychological, or neurological diseases/conditions that
             would influence the study outcomes.

          -  Not currently/previously on a weight loss or other special diet (in the past 6 months)

          -  Skip lunch ( ≥ 2 eating occasions/wk)

          -  Consume breakfast (≥ 2 eating occasions/wk)

          -  Left-handed

          -  Claustrophobic (≥ 2 past bouts of claustrophobia when exposure to small spaces)

          -  Do not meet the fMRI criteria established by the MU-BIC (regarding metal implants,
             etc.)

          -  Pregnant
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 20 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Parents/Caregivers:

          -  Parent or caregiver of child with DMD and child without DMD

          -  Lives with child that does not have DMD

          -  18 or older

          -  Reads/Writes English

        Siblings:

          -  Sibling of child with DMD

          -  Lives in same household as individual with DMD

          -  13-18 years of age

          -  Reads/Writes English
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Efficacy of Surgical Treatment After Neoadjuvant Chemotherapy Plus Intraperitoneal Immunotherapy Versus Chemotherapy Alone for Patients With Positive Wash Cytology Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  ECOG 0-2

          -  Histologically proven gastric cancer T2-3 N+, T4a with any N (0,+) with free cancer
             cells in the abdominal cavity and no macroscopic canceromathosis and no other distant
             metastases (TNM classification 7th edition)

          -  Histological forms: gastric adenocarcinoma and signet ring cancer

          -  Blood characteristics (creatinine <150 mg/l, total bilirubin < 50 mkmol/l, neutrophils
             < 1500/mkl, hemoglobin >90 g/l, thrombocytes > 100000/mkl)

        Exclusion Criteria:

          -  Clinically apparent distant metastasis (besides free cancer cells)

          -  Synchronic or metachronic malignant tumors

          -  Previous systemic or surgical or combined therapy for gastric cancer

          -  Complications of gastric cancer (obstruction 0-1 GOOSS scale and/or gastric bleeding)

          -  Adhesions in abdominal cavity

          -  Gastrooesophageal junction cancer or gastric cancer with spreading on oesophagus.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  GERD patients:

               -  typical symptoms of reflux, such as heartburn and/or regurgitation;

               -  gastro-esophageal reflux assessed by 24-h pH-impedance monitoring or a positive
                  symptom association or;

               -  esophagitis assessed by upper GI endoscopy with careful evaluation of the
                  presence and extent of a hiatal hernia (HH).

          -  GERD/FD overlap:

               -  FD symptoms according to the Rome III criteria. The symptoms of FD include one or
                  more of: bothersome postprandial fullness occurring after normal sized meals,
                  early satiation that prevents finishing a regular meal, epigastric pain, and
                  epigastric burning at least several times per week during the last 6 months.

        Exclusion Criteria:

          -  Healthy volunteers:

               -  history of any upper gastrointestinal (GI) symptoms or GI surgery;

               -  psychological disorders;

               -  any drug history;

               -  use of medication altering GI motility;

               -  pregnant or nursing women.

          -  GERD patients:

               -  psychological disorders;

               -  any drug history;

               -  use of medication affecting GI motility;

               -  pregnant or nursing women;

               -  history of GI surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Late Clinical Events Associated With COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          -  History of symptomatic CoV-2-SARS infection as defined by :

             o Positive RT-PCR SARS-CoV-2 RT-PCR result OR positive SARS-CoV-2 serology

             o Associated with at least one event : x Anosmia occurring after February 2020 x OR
             COVID 19 evocative scanner x OR ≥ 2 contemporary symptoms of the virological sample
             from: asthenia, cough, dyspnea, fever, myalgia, dysgeusia, diarrhea AND not present
             prior to diagnosis

          -  AND persistence of at least one symptom present in the first 3 weeks of a COVID-19,
             more than 8 weeks away from the first symptoms of COVID-19. OR late onset of at least
             one new symptom a minimum of 3 weeks and a maximum of 6 months after the first
             symptoms of a CoV-2 SARS infection.

          -  First symptoms less than 6 months old on the day of inclusion

          -  To benefit from a State Health Insurance or Medical Aid plan

          -  Have signed an informed consent for inclusion.

        Exclusion Criteria:

          -  Minor patient

          -  Patient under protection of justice

          -  Patient who required intensive care management :

               -  more than 5 days

               -  OR requiring orotracheal intubation

               -  OR having required high flow ventilation (optiflow)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Von Willebrand Disease in the Netherlands

Eligibility criteria:
Inclusion Criteria:

          -  Historically lowest VWF:Ag and/or VWF:RCo and/or VWF:CB ≤ 0.30 IU/mL and/or FVIII:C ≤
             0.40 IU/mL

          -  Treatment at a Hemophilia treatment center in the Netherlands

          -  All types of VWD

          -  All ages

        Exclusion Criteria:

        - Other known bleeding disorders present.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction