Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient's own account: My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Clinical trial: Identification Genetic, Immunologic and Microbial Markers of Hirschsprung Associated Enterocolitis in Children With Hirschsprung Disease

Eligibility criteria:
Inclusion Criteria:

          -  1. Males and females of all ages with a confirmed diagnosis of HD based on
             standardized histological criteria. Only Males and females ages 0 to 17 with a
             confirmed diagnosis of HD based on standardized histological criteria will be enrolled
             at CSMC.

          -  2. Able to provide written informed assent if between the ages of 7 and 17. If age 6
             and under, able to participate with parental permission.

          -  3. Have consented to have specimens tested for genetics, immune responses, stool
             microflora.

        Case Ascertainment:

        All patients with a confirmed diagnosis of HD are eligible for enrollment. A diagnosis of
        HD for this study will require:

          -  1)Documented histopathology showing absence of ganglion cells and is consistent with
             the diagnosis of HD.

        Exclusion Criteria:

          -  1. Intestinal neuronal dysplasia

          -  2. Pseudo-obstruction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Pelvic Floor Muscle Function in Nulliparous and Primiparous.

Eligibility criteria:
Inclusion Criteria:

        - Nulliparous and primiparous

        Exclusion Criteria:

          -  in G1 (nulliparous) were UI, neurological diseases, previous pelvic surgeries,
             diabetes, smoking and cognitive difficulties. In G2 (primiparas), the same criteria
             were used including women with gestational complications such as diabetes,
             hypertension, vaginal and urinary infection.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 30 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Study of Intravenously or Subcutaneously Administered REGN3500 in Healthy Adult Subjects

Eligibility criteria:
Inclusion Criteria:

          -  Body Mass Index</= 33 kg/m2

          -  In good health based on medical history, physical examination, vital signs, and
             laboratory testing

          -  Normal electrocardiogram (ECG) and blood pressure

          -  Able to comply with clinic visits and study-related procedures

          -  Able to sign an informed consent

        Exclusion Criteria:

          -  Significant abnormalities in hematology, clinical chemistry, urinalysis, medical
             history

          -  Current smoker or recent history (within 3 months)

          -  History of tuberculosis, HIV, or hepatic disease

          -  Known sensitivity to doxycycline or other ingredients of study drug

          -  History of multiple/severe allergies

          -  Pregnant or breastfeeding women, or not currently using adequate contraception

          -  Participation in another investigational drug study within 4 weeks
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Adult persons with average age of 20-60 years.

          -  Persons coming to outpatient clinic and trauma unit complaining Of Chronic Wrist pain

          -  Plain x-ray films Antero-posterior View And lateral views of the Wrist

        Exclusion Criteria:

          -  Persons < 20 years or > 60 years.

          -  Traumatic WristWithFracture

          -  Previous Wrist surgery.

          -  Patient With Condraindication To plain X-Ray
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Workshops for Veterans With Vision and Hearing Loss

Eligibility criteria:
Inclusion Criteria:

          -  Veteran;

          -  Vision loss > 20/70 better eye;

          -  Hearing loss > 40 decibels better ear;

          -  Cognition Within Normal Limits (WNL);

          -  No behavioral flag or psychiatric diagnosis;

          -  Documented psychosocial restrictions secondary to vision and hearing loss

        Exclusion Criteria:

          -  Vision and/or hearing can be corrected by surgical or pharmacological treatment;

          -  Requires use of sign language interpreter
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Determination of the Effectiveness of Certain Physical Methods in the Treatment of Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  radiological evidence of primary OA with Grade 1 and 2 on the Kellgren-Lawrence Scale

          -  knee pain for 3 months

          -  knee osteoarthritis defined by American College of Rheumatology Criteria

        Exclusion Criteria:

          -  surgery on that knee

          -  pacemaker

          -  metallic foreign body in the area of stimulation

          -  thrombophlebitis and thrombosis

          -  skin infection

          -  malignancy,

          -  bleeding disorders

          -  neurological disease

          -  inflammatory rheumatology disease

          -  congenital and acquired knee deformities

          -  contracture of the hips and ankles

          -  grade 3 and 4 osteoarthritis om the Kellgren and Lawrence classification

          -  intraarticular injection in the last 3 months

          -  post-traumatic knee osteoarthritis and osteonecrosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Evaluation of the Relationship Between Air Bubbles Depth and Pregnancy Rate in ICSI Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Women in reproductive period (age 18-38 years).

          -  Infertility due to bilateral tubal block or unexplained infertility programmed for
             ICSI.

          -  BMI < 25 kg/m².

          -  FSH level on cycle day 3 of < 12 mIU/mL

        Exclusion Criteria:

          -  Previous failed ICSI or IVF attempts.

          -  Infertility due to male factors.

          -  Presence of an abnormal uterine cavity due to endometrial polyps, myomas distorting
             the uterine cavity, Mullerian malformations, endometrial synechiae, etc. (assessed by
             transvaginal US and/or hysterography).

          -  Patients with hydrosalpinx or pyosalpinx.

          -  Patients undergoing ET after cryopreservation.

          -  Patients with blood present on the catheter during the transfer procedure.

          -  Patients with difficult transfer or with suspicion of touching the fundus.

          -  Poor responders.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 38 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Gingival Bleeding and Von Willebrand Disease Typ 2 and 3

Eligibility criteria:
Inclusion Criteria von Willebrand Patients:

          -  18 - 80 years old

          -  no other bleeding disorder except 2 and 3 von Willebrand disease

        Inclusion Criteria healthy controls:

          -  no bleeding disorder

          -  no anticoagulative medication

        Exclusion Criteria von Willebrand Patients:

        - requirement of systemic antibiotics for measures that may cause transitory bacteraemia

        Exclusion Criteria healthy controls:

        - bleeding disorder
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Effects of Tranexemic Acid Versus Norethisterone Acetate on Endometrial Vasculature .

Eligibility criteria:
Inclusion Criteria:

          -  Age: 35-49 years old.

          -  Normal gynecologic and breast examination

          -  Women who have sterilization or husband is sterilized or accepts to use a suitable
             barrier contraception during the duration of the study.

          -  Heavy periods (were assessed by validated pictorial blood chart)

          -  Normal ultrasound, hysteroscopy and endometrial biopsy.

          -  Normal coagulation profile and thyroid function.

          -  No contraindication to tranexamic acid or Norethisterone acetate : allergy,History of
             arterial or venous thromboembolic disease,Disturbance of liver function or Severe
             renal impairment.

        Exclusion Criteria:

          -  Women who are less than 35 years old or more than 49 years old.

          -  Women who had organic cause for heavy periods as uterine polypi,fibroids or
             endometriosis.

          -  Women taking hormonal preparation the month before starting the trial.

          -  Women with abnormal findings in pelvic ultrasound,hysteroscopy or endometrial biopsy.

          -  Women who suffer from uncontrolled diabetes or uncontrolled hypertension.

          -  Women with history of breast cancer or precancerous conditions.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Risk Stratification of COVID-19 Patients Discharged From the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic COVID-19 confirmed by treating physician

          -  positive nasopharyngeal swab for SARS-CoV-2 (performed during the ED visit or within
             last 14 days)

          -  First ED visit for suspected or confirmed COVID-19 (within last 30 days)

          -  Home discharge from ED based on treating physician's or patient's decision

        Exclusion Criteria:

          -  Age <18 years

          -  Nursing home resident

          -  Already on home oxygen therapy

          -  Previous ED visit for suspected or confirmed COVID-19 (within last 30 days)

          -  Informed consent denial

          -  Follow-up not feasible
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment