Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss

Eligibility criteria:
Inclusion Criteria:

          -  Women ages 18-50 who are English or Spanish speaking

          -  First trimester pregnancy (less than 13 weeks and 0 days)

          -  Desires medical management of an early pregnancy loss with misoprostol

          -  Diagnosed with an early pregnancy failure by UCSD Radiology or diagnosed early
             pregnancy failure defined by any of the following criteria (Bourne 2013):

               -  Crown-rump length > 7mm with no cardiac activity

               -  Mean gestational sac diameter of > 25 mm and no embryo

               -  Absence of an embryo with heartbeat > 2 weeks after a scan showing a gestational
                  sac without a yolk sac

               -  Absence of embryo with heartbeat > 11 days after a scan showing a gestational sac
                  with a yolk sac

        Exclusion Criteria:

          -  Evidence of infection, acute hemorrhage, or hemodynamic instability

          -  Hemoglobin less than 9.5 including use of point of care Hgb testing

          -  Known allergy to misoprostol

          -  Underwent surgical or medical abortion during current pregnancy

          -  Currently breastfeeding

          -  Currently has intrauterine device in place

          -  Suspicion of ectopic or gestational trophoblastic disease

          -  History of clotting disorder or on anticoagulant therapy (excluding aspirin)

          -  Unreliable for follow up
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Hydrocodone For Pain Control in First Trimester Surgical Abortion

Eligibility criteria:
Inclusion Criteria:

          -  Aged 18 years or older

          -  Voluntarily requesting surgical pregnancy termination

          -  Pregnancy with intrauterine gestational sac up to 10 weeks 6 days gestation, dated by
             ultrasound

          -  Eligible for suction curettage

          -  English or Spanish speaking

          -  Good general health

          -  Able and willing to give informed consent and agree to terms of the study

        Exclusion Criteria:

          -  Gestational ages 11 weeks or more

          -  Incomplete abortion

          -  Premedication with misoprostol

          -  Use of any opioid medication within the past 7 days

          -  Use of heroin within the past 7 days

          -  Requested opioids or IV sedation prior to start of the procedure

          -  Patients who refuse ibuprofen or lorazepam

          -  Contraindications or allergies to HC/APAP, lidocaine, ibuprofen, or lorazepam

          -  Significant medical problem necessitating inpatient procedure

          -  Adnexal mass or tenderness on pelvic exam consistent with pelvic inflammatory disease

          -  Known hepatic disease
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Web-based Application for the Population Pharmacokinetic Service - Phase 1

Eligibility criteria:
Inclusion Criteria:

          -  Patients with severe or moderate Hemophilia A or B

          -  Informed consent to data processing

        Exclusion Criteria:

          -  Non measurable plasma factor VIII due to high titre inhibitor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Tissue Factor Pathway Inhibitor (TFPI) and Haemorrhagic Manifestations in Haemophilia A and B Patients

Eligibility criteria:
Inclusion Criteria:

          -  Haemophilia A and B patients between 18 and 65 years old, whatever the severity of
             their disease, who have signed the informed consent form

          -  On-demand or on prophylactic therapy.

          -  Regular monitoring in investigator center.

        Exclusion Criteria:

          -  - Haemophilia patients under 18.

          -  Presence of an inhibitor at any time before or during the study period.

          -  Patients who received factor VIII concentrate less than 72 hours or factor IX
             concentrate less than 96 hours before blood collection

          -  Patients who refused to sign informed consent

          -  Patient data over the last 5 years at least not available.

          -  No regular monitoring in haemophilia center (required at least one visit every 18
             months for severe or moderate hemophiliac patients).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Treatment of Tendon Injury Using Mesenchymal Stem Cells

Eligibility criteria:
Inclusion Criteria:

          -  clinically diagnosed as lateral epicondylitis (tennis elbow)

          -  recurrent pain in spite of conservative treatment such as physical therapy,
             medication, steroid injection

          -  symptom duration is over 6 months

          -  defect in common extensor tendon can be observed under ultrasound

          -  patient that can understand the clinical trials

        Exclusion Criteria:

          -  patient that underwent other injection treatment within 6 weeks

          -  some associated diseases (such as arthritis, synovitis, entrapment of related nerve,
             radiculopathy to the target lesion, generalized pain syndrome, rheumatoid arthritis,
             pregnancy, impaired sensibility, paralysis, history of allergic or hypersensitive
             reaction to bovine-derived proteins or fibrin glue)

          -  patient that enrolled other clinical trials within 30 days

          -  history of drug/alcohol addiction, habitual smoker
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Bullying in Youth With Muscular Dystrophy and Congenital Myopathies

Eligibility criteria:
Inclusion Criteria:

          -  Muscular dystrophy or congenital myopathy diagnosis

          -  10-19 years old

          -  Speaks and reads English or French

        Exclusion Criteria:

          -  N/A
No condition on gender to be admitted to the trial.

Subject must be at least 10 Years old.
Subject must be at most 19 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of sarcoidosis

          -  Signed informed consent

        Exclusion Criteria:

          -  Inability or unwillingness to adhere to the study

          -  Inability to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: Study to Evaluate Efficacy of Odanacatib (MK-0822) on Bone Mineral Density (BMD) and Bone Micro-architecture and Overall Safety in Postmenopausal Women (MK-0822-031)

Eligibility criteria:
Inclusion Criteria:

          -  Participant has been postmenopausal for 3 years

          -  Participant has BMD t-score at the total hip, hip trochanter, femoral neck, or lumbar
             spine ≥ -1.5 but > -3.5

          -  Participant has 2 hips that are evaluable by dual-energy X-ray absorptiometry (DXA)
             and quantitative computed tomography (QCT), e.g. contain no hardware from orthopedic
             procedures

          -  Participant is ambulatory

        Exclusion Criteria:

          -  Participant has had a previous hip fracture

          -  Participant has had >1 prior clinical vertebral fracture AND is a candidate for
             osteoporosis therapy

          -  Participant has been treated with oral bisphosphonates, strontium, parathyroid hormone
             (PTH) or other agents with an effect on bone

          -  Participant has had metabolic bone disorder other than osteoporosis

          -  Participant has renal stones, Parkinson's disease, multiple sclerosis (MS) or active
             parathyroid disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: A Controlled Comparison of Two DBS Targets for Upper Extremity Action Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Min 5-yr duration chronic action tremor of upper limb(s), w/ or w/out tremor of
             head/neck, trunk, lower limbs, who have insufficient relief from adequate trials of
             recommended medications. The arm tremor must be so severe that it interferes with the
             patient's work performance or activities of daily living, such as drinking/eating,
             dressing/hygiene, and/or writing. Clinical diagnosis (according to criteria defined by
             the Consensus Statement of the Movement Disorders Society) include Essential Tremor,
             Dystonic Tremor, Cerebellar Tremor- idiopathic or secondary (to e.g.MS or SCA), or
             severe PD tremor (who are not eligible for DBS of the subthalamic nucleus).

        Exclusion Criteria:

          -  Brain MRI showing so marked general atrophy, or supra-tentorial white matter changes,
             that the safety of the procedure is affected. Co-morbidity of dementia or other severe
             neuropsychiatric disorder (major depression or anxiety disorder, active/recent
             psychosis, drug or other substance abuse). Increased risk of bleeding, cancer at
             advanced/not stabilized stage, other severe co-morbidity (e.g. With chronic pain,
             short life expectancy,). Other surgical contraindications.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A RCT of Supportive Finger Tape for PIPJ Osteoarthritis

Eligibility criteria:
Inclusion criteria:

        All adult patients (≥18 years old) with chronic osteoarthritis of the PIPJ of any finger.

        Exclusion criteria:

        Patients meeting any of the below criteria will be excluded:

          -  Patients lacking capacity to consent (unable to understand, retain, weigh up or
             communicate their decision)

          -  Patients (and/or their carers) who lack the dexterity to cut and apply the Suture
             Strips to the painful finger.

          -  Patients with active infection or unhealed wounds on the same hand as this may
             confound the level of pain experienced.

          -  Dermatological conditions or vulnerable dorsal finger skin on the proposed trial
             finger, which may be exacerbated or damaged respectively by the applicable/removal of
             tape
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment