Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Corticosteroid and Lidocain Injections for Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  Between 20 and 75 years of age, with lateral elbow pain ≥4 in pain VAS for at least 1
             month

          -  Reproducibility of pain by 2 or more of the following tests: palpation of the lateral
             epicondyle and/or the common extensor origin of the elbow; resisted wrist extension
             (dorsiflexion) and pronation with the elbow in extension

          -  Pain reproduced by static stretching of the pronated wrist in palmar flexion with the
             elbow in extension.

        Exclusion Criteria:

          -  not fulfill inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Confident Birthing: What Influences Women's Confidence for Birth?

Eligibility criteria:
Inclusion Criteria:

          -  given birth within the last two years or are pregnant

          -  consider themselves well enough to take part in the study

          -  have received maternity care from specific NHS Trust

        Exclusion Criteria:

          -  under 18 years old

          -  have not received maternity care from specific NHS Trust
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Couples With Mild Male Factor Infertility

Eligibility criteria:
Inclusion Criteria:

          -  Mild male factor infertility defined as meaning two or more semen analyses that have
             one or more variables which fall below the 5th centile as defined by the World Health
             Organization, and where the effect on the chance of pregnancy occurring naturally
             through vaginal intercourse within a period of 24 months would then be similar to
             people with unexplained infertility or mild endometriosis.

        Exclusion Criteria:

          -  Known allergy to FSH

          -  Other factors of infertility.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Clinical Study to Investigate the PK, Efficacy, and Safety of Wilate in Patients With Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Severe hemophilia A (<1% FVIII:C) according to medical history

          2. Male patients aged ≥12 years

          3. Previous treatment with a FVIII concentrate for at least 150 exposure days (EDs)

          4. Immunocompetence (CD4+ count >200/µL)

          5. Good documentation of the historical bleeding rate (at least for the 6 months
             preceding study start)

          6. Voluntarily given, fully informed written and signed consent obtained by the patient
             (or parent/legal guardian in case of adolescents) before any study-related procedures
             are conducted

        Whenever possible, the interval between the Screening Visit and the PK or Non-PK Visit
        should not exceed 30 days. If the 30-day interval is exceeded, determination of the CD4+
        count is to be repeated and must be >200/µL for patients to be enrolled (i.e., exclusion
        criterion no. 4).

        Exclusion Criteria:

          1. Any coagulation disorders other than hemophilia A

          2. History of FVIII inhibitor activity (≥0.6 BU) or detectable FVIII inhibitory
             anti-bodies (≥0.6 BU using the Nijmegen modification of the Bethesda assay) at
             screening, as determined by the central laboratory

          3. Severe liver or kidney diseases (alanine aminotransferase [ALAT] and aspartate
             transaminase [ASAT] levels >5 times of upper limit of normal, creatinine>120 µmol/L)

          4. Patients receiving or scheduled to receive immunomodulating drugs (other than
             anti-retroviral chemotherapy) such as alpha-interferon, prednisone (equivalent to >10
             mg/day), or similar drugs

          5. Treatment with any investigational medicinal product in another interventional
             clinical study currently or within 4 weeks before enrollment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Herzuma-capecitabine/Cisplatin for Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Gastric or gastroesophageal junction adenocarcinoma

          2. HER-2 immuno-histochemical (IHC) (3 +) stain or her-2 silver in situ
             hybridization(SISH)/fluorescence in situ hybridization(FISH) (+)

          3. Herzuma® -capecitabine/cisplatin combination regimen is planned as a first line
             treatment

        Exclusion Criteria:

          1. Other type of cancer of Gastric or gastroesophageal junction adenocarcinoma (e.g.,
             lymphoma, sarcoma)

          2. HER-2 (0/1+) in IHC or her-2 SISH/FISH (-).

          3. Patients who previously performed stomach cancer treatment as a palliative setting.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Prospective Study of Diagnostic Accuracy of Ultrasound

Eligibility criteria:
Inclusion Criteria:

          -  Women

          -  18 years or older but 60 years or less.

          -  Undergoing hysterectomy for AUB or pelvic pain

        Exclusion Criteria:

          -  known cause of AUB or pelvic pain
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Lifestyle Online Intervention On EB and BMI On Obese Hypertensive Adults

Eligibility criteria:
Inclusion Criteria:

          -  Hypertension

          -  Overweight or obesity (25 ≤ BMI ≤ 35 kg/m2)

          -  Aged between 18-75 years

          -  Being a participant of the program 5 years ago

        Exclusion Criteria:

          -  Not having access to the Internet or lack of information about it.

          -  Treatment with more than 3 antihypertensive drugs.

          -  Meet the criteria of the DSM-IV-TR of a Food Disorder.

          -  Presenting some type of severe psychiatric disorder.

          -  Disability that prevents or hinders physical exercise.

          -  Receiving some treatment for weight loss.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Neuromuscular Transmission in Amyotrophic Lateral Sclerosis

Eligibility criteria:
1. ALS patients:

             Inclusion criteria :

               -  Aged 18 to 75 (inclusive)

               -  Possible, probable (clinically or laboratory) or definite ALS according to the
                  revised El Escorial criteria

               -  Duration of the disease of less then 12 months

               -  Willing and able to provide a written informed consent

               -  With french social insurance affiliation

             Exclusion criteria :

               -  Cognitive changes or psychiatric condition, inability to give informed consent

               -  patient unable to contact or to be contacted by the investigator in case of
                  emergency

               -  women who are pregnant or nursing

               -  concomitant medication contraindicating muscular biopsy (platelet suppressive
                  agents if treatment can not medically be stopped 2 weeks before surgical
                  procedure, oral anticoagulant therapy)

               -  medical condition contraindicating muscular biopsy (hypo-coagulative disease,
                  allergy to anaesthetic drugs)

               -  medical condition susceptible to influence on EMG examination (concomitant
                  neurological or rheumatological disease)

          2. Controls:

               -  adult patients (minimum 18y) without neuromuscular disease

               -  undergoing elbow surgery for local joint or bone disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable Alzheimer's Disease or mild cognitive impairment

          -  Mini Mental State Examination (MMSE) score between 18 and 26

          -  Clinical Dementia Rating (CDR) of 0.5 or 1.0

          -  Fluent in English

        Exclusion Criteria:

          -  Use of lipid lowering medications

          -  Consumption of fish of more than twice a week

          -  Use of omega and alpha lipoic acid supplements

          -  Use of systemic corticosteroids, neuroleptics, anti-Parkinsonian agents, or narcotic
             analgesics

          -  Depression

          -  Any other serious health conditions that may interfere with the study

          -  Enrollment in another clinical trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Botulinum Toxin Versus Active Strength Training in the Treatment of Lateral Epicondylitis

Eligibility criteria:
Inclusion Criteria:

          -  pain at the lateral side of the elbow over 3 months

          -  local tenderness on palpation over the lateral epicondyle

          -  positive Mill's sign

          -  lateral elbow pain progression on resisted wrist and/or middle finger extension

          -  involved in working life

        Exclusion Criteria:

          -  bilateral symptoms or simultaneous medial epicondylitis

          -  verified or suspected cervical radiculopathy or affected limb neuropathy

          -  congenital or acquired deformities of the elbow

          -  previous surgery of the elbow

          -  infection, dislocation, tendon ruptures, or fractures in the area

          -  systemic musculoskeletal or neurological disorders, incl. rheumatic diseases and
             fibromyalgia

          -  allergy, antibodies or other contraindications for botulinum toxin

          -  severe depression, chronic pain syndrome or somatisation disorder

          -  ongoing retirement process

          -  pregnancy or breastfeeding

          -  current participation in other clinical trials
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction