Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Men

          -  Treatment naive

          -  Hypogonadotrophic hypogonadism

        Exclusion Criteria:

          -  Previous history of androgen replacement

          -  Chronic metabolic disorders
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 26 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Correlation of Oropharyngeal Pepsin and Gastroesophageal (GE) Reflux

Eligibility criteria:
Inclusion Criteria:

          1. Pediatric patients from birth to 18 years (including premature infants) who are deemed
             clinically to require 24 hour esophageal pH/impedance.

          2. Pediatric patients (newborn to 18 years) undergoing MBS who have had or will have
             pH/MII monitoring within 6 months.

          3. Patients' parents or legal guardians will provide written informed consent for the
             protocol. When appropriate, patient assent will be obtained.

        Exclusion Criteria:

          1. Patients with anatomic facial anomalies or facial discomfort precluding nasal
             intubation of the pH/MII catheter.

          2. Patient unable to complete a 24 hour pH/MII study.

          3. Children fed exclusively with nasogastric or nasojejunal (transpyloric) tube at the
             time of study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Trans-inguinal Pre-peritoneal Hernioplasty Versus Lichtnestein's Technique in Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  . Patients with unilateral non complicated inguinal hernia who will undergo
             hernioplasty in surgery department at AUH

        Exclusion Criteria:

          1. Patients who were unfit for operation.

          2. Patients with bilateral or recurrent inguinal hernia

          3. Patients aged below 18 years,

          4. Patients undergoing emergency hernia repairs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux

Eligibility criteria:
Inclusion Criteria:

          -  They complain of symptoms of ear fullness, ear pain, and/or ear pressure, either
             unilateral or bilateral

          -  They are willing to participate in the study.

          -  They are between the ages of 18 to 80

        Exclusion Criteria:

          -  They have had major ear surgery (not including tympanostomy tubes)

          -  They have a medical condition that is another possible etiology of ear pain or acid
             reflux and may require additional medical or surgical intervention such as: Acute or
             chronic otitis externa, Chronic otitis media, Temporomandibular joint dysfunction,
             Upper aerodigestive track neoplasm, History of head/neck radiation therapy.

          -  They are pregnant. Proton pump inhibitors are a Category C drug with unknown pregnancy
             risks.

          -  They do not wish to participate in the study

          -  They are <18 or >80.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Whey Protein on Posprandial Glucose, Insulin GLP-1, GIP and DPP4 in Type 2 Diabetes

Eligibility criteria:
Inclusion Criteria:

          1. Type 2 diabetic patients

          2. Duration of diabetes: 1-10 years

          3. Subjects ≥ 40 and ≤70 years of age

          4. Metformin therapy and all oral antidiabetic medication will be allowed

          5. Overweight or obese (BMI: 25 to 35 kg/m2)

          6. Normal liver and kidney function

          7. Normal thyroid function

          8. Read and understood the informed consent form and signed it voluntarily

        Exclusion Criteria:

          1. Liver, heart, kidney, lung, infectious, neurological, psychiatric, immunological or
             neoplastic diseases.

          2. Type 1 or insulin treated diabetes.

          3. Pregnancy or lactation

          4. Illicit drug abuse or alcoholism

          5. Subject treated with insulin or treatment with degradation-resistant GLP-1R agonists
             (Exendin-4) or similar and DPP4 inhibitors (Januvia)

          6. Subjects taking anoretic drugs

          7. Subjects on steroid treatment

          8. Subjects known by the principal investigator to be unable to cooperate for any reason.

          9. Known hypersensitivity to milk components

         10. Subjects after bariatric surgery.

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Memory and Picture Viewing Study

Eligibility criteria:
Inclusion Criteria:

          -  generally healthy

          -  right-handed non-smokers

          -  between the ages of 18-55

          -  an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100
             ng/mL or less (to confirm a non-smoker)

          -  having smoked < 50 cigarettes in their lifetime

        Exclusion Criteria:

          -  inability to attend all sessions

          -  significant health problems (hypertension, emphysema, seizure disorder, history of
             significant heart problems)

          -  use of psychoactive medications

          -  use of any tobacco or nicotine containing products

          -  current alcohol or drug abuse

          -  use of illegal drugs as measure by a urine drug screen

          -  presence of conditions that would make MRI unsafe (pacemaker, metallic implants
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Platelet Rich Plasma Injection for Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  stage 1-2-3 symptomatic OA patients according to Kellgren / Lawrence staging

          -  mean VAS pain score of >4 of 10 (worst possible pain) over the course of 7 days during
             the previous month

        Exclusion Criteria:

          -  OA secondary to joint inflammatory diseases,

          -  generalized OA,

          -  metabolic diseases of the bone,

          -  coexisting backache,

          -  the presence of hematological disease (coagulopathy),

          -  bilateral symptomatic lesions and advanced stages (grade 4) of OA,

          -  patients who had received intra-articular injections within 3 months or arthroscopic
             lavage in the previous 1 year,

          -  patients who were receiving immunosuppressive,

          -  patients with current use of anticoagulant medications,

          -  NSAIDs used in the 5 days before blood donation,

          -  major axis deviation (more than 15 degree of varus or more than 5 degree of valgus
             deviation),

          -  patients with a hemoglobin level less than 11.5 g/dL,

          -  platelets level less than 100,000/μL,

          -  associated comorbidities, infection, tumor, crystal arthropathies, anemia, tense joint
             effusion and pregnancy or possibility of pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient's own account: I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Clinical trial: Bronchodilators for Wheeze in Young Children Presenting to Primary Care: a Randomised, Placebo-controlled, Multicentre, Parallel Group Trial

Eligibility criteria:
Inclusion Criteria:

          -  Presenting to their primary care physician because of wheezing as confirmed by
             clinical examination (chest auscultation)

          -  A baseline score of 7 or higher on a parent-reported respiratory symptom score

        Exclusion Criteria:

          -  Prematurity (<37 weeks)

          -  Major congenital malformations

          -  Pre-existing pulmonary disease as diagnosed by a paediatrician

          -  Continuous use of inhalation medication

          -  Physician visit because of wheezing in previous two weeks

          -  Use of inhalation medication in the previous two weeks

          -  Wheezing as a result of upper airway obstruction (i.e. laryngitis
             subglottica/pseudocroup)

          -  Severe illness requiring inhalation medication, prescription of antibiotics, or
             hospital referral during the consultation of inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 24 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Effect of Exercise in Pediatric Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with hemophilia (Hemophilia A) by a hematologist

          -  Hemophilia is moderate or severe, without spontaneous bleeding complaints

          -  Having a history of bleeding in the knee joint

          -  Not doing any regular exercise

          -  Willing to continue working and will not start other treatment during the study

          -  Patients whose parents were informed about the study and whose consent form was
             obtained

        Exclusion Criteria:

          -  Those who have undergone another surgery (joint debridement, fracture, knee
             replacement) that will affect lower extremity function

          -  Those with neurological disease or any sensory loss or peripheral nerve injury that
             may affect functional performance and balance
Male
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluate Efficacy and Safety of ADVATE in the Standard Prophylaxis Treatment of Severe or Moderately Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Subject has hemophilia A with FVIII≤2 %.

          2. Previously treated patients (PTPs).

          3. Age from 2 to 18 years.

        Exclusion Criteria:

          1. Subject has known hypersensitivity to the active substance or any of the excipients.

          2. Subject has known allergic reaction to mouse or hamster proteins.

          3. Subject has participated in another clinical study involving an investigational
             product (IP) or device within 30 days prior to study enrollment or is scheduled to
             participate in another clinical study involving another FVIII concentrate or device
             during the course of this study.

          4. Subject is planned, or likely to have surgery during the study period.

          5. Subject has end-stage renal failure or evidence of a severe or uncontrolled systemic
             disease as judged by the investigator.

          6. Subject has full-blown Acquired Immuno Deficiency Syndrome (AIDS),determined by
             cluster differentiation antigen 4+ (CD4+) and clinical presentation.

          7. Subject has active hepatic disease (alanine aminotransferase (ALT) and aspartate
             aminotransferase (AST) levels > 5 times the upper limit of normal).

          8. Subject has clinical or laboratory evidence of severe liver impairment including (but
             not limited to) a recent and persistent international normalized ratio (INR)> 1.4,
             and/or the presence of splenomegaly and/or significant spider angioma on physical
             exam, and/or a history of esophageal hemorrhage or documented esophageal varices.

          9. The subject in the opinion of the investigator is unable or unwilling to comply with
             study protocol

         10. Subject is a family member of the investigator or site staff
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction