Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Prolonged Symptoms and Reasons for Consultation in Town Medicine Associated With COVID-19 Infection in the Hauts de France Region

Eligibility criteria:
Inclusion Criteria:

        A- For COVID cases:

          1. Consultation in a city doctor's office

          2. Positive SARS-CoV-2 RT-PCR result OR positive SARS-CoV-2 serology

          3. Patient symptomatic or not

        Definition of symptomatic :

          1. Anosmia

          2. OR CT scan suggestive of COVID 19

          3. OR ≥ 2 symptoms contemporaneous with virologic sampling among: asthenia, cough,
             dyspnea, fever, myalgias, dysgeusia, diarrhea AND not present previously at diagnosis

        B-. For NON COVID cases:

          1. Consultation in a city doctor's office

          2. No known COVID+ serology

          3. No known RT- PCR SARS-CoV-2

          4. No clinical suspicion of COVID-19 infection

        Exclusion Criteria:

          1. Minor patient

          2. Refusal to participate

          3. Patient under protection

          4. Patient requiring hospitalization for COVID-19 (excluding non-emergency
             hospitalization)

          5. Patient consulted for the following reason only: treatment monitoring, treatment
             renewal or certificate, hospital discharge
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Genetic Causes of Male Infertility

Eligibility criteria:
-  INCLUSION CRITERIA INFERTILE MEN:

        Referred to the Scanian Andrology Centre.

        Age 20-45.

        Partner age less than 40.

        Having had regular sexual intercourse without contraception for a year or more without
        achieving a pregnancy.

        EXCLUSION CRITERIA INFERTILE MEN:

        Klinefelters syndrome.

        Hypogondotropic hypogonadism.

        Y-chromosome microdeletion or abnormality.

        Other genetic cause for infertility.

        Obstructive azoospermia.

        Partner with salpingitis.

        Partner with polycystic ovarian syndrome.

        Partner with disturbance of ovulation.

        Partner with endometriosis.

        History of cancer.

        History of treatment with cytotoxic drugs, irradiation, or sulfasalazopyrine.

        History of cryptorchidism.

        History of mumps orchitis.

        History of vasectomy.

        INCLUSION CRITERIA FERTILE MEN:

        Partner attending Lund University prenatal clinic.

        Age 20-45.

        Partner age less than 40.

        Having fathered one or more pregnancies.

        Having stopped birth control to achieve present pregnancy.

        Having achieved present pregnancy in less than 12 months of unprotected intercourse.

        EXCLUSION CRITERIA FERTILE MEN:

        History of cancer.

        History of treatment with cytotoxic drugs, irradiation, or sulfasalazopyrine.

        History of cryptorchidism.

        History of mumps orchitis.

        Having sought or partner having sought treatment or investigation for fertility.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Validating the Hum Test

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-35

          -  Subjective normal hearing and no previous complaints or history of hearing problems or
             otologic disorders

          -  Subjects will be NYU medical students, NYU resident physicians, or patients from the
             Long Island Cochlear Implant Center

        Exclusion Criteria:

          -  Has not had a URI (assessed by asking patient if they have had fever, cough, sore
             throat, nasal congestion, or runny nose) within one month of study session
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient's own account: I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Clinical trial: Role of Provider-at-Triage on ED Efficiency and Quality of Care

Eligibility criteria:
Inclusion Criteria:

        Participants are eligible to participate in the study if they are:

          -  English speaking

          -  Without hemodynamic or respiratory compromise

          -  Do not have a nurse-assigned triage severity score of Emergency Severity Index 1 (most
             severe illness or injury score).

        Exclusion Criteria:

        Participants will be excluded if they are:

          -  Unwilling or unable to sign an informed consent

          -  In police custody

          -  Too ill to participate in study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 110 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening

Eligibility criteria:
Adults with suspected adrenal disease, such as adrenal adenoma, carcinoma, hyperplasia, or
        Addison's Disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Study of Acamprosate in Fragile x Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Diagnostic confirmation of full mutation FXS

          -  Age ≥5 years and <23 years

          -  General good health as determined by physical exam, medical history and laboratory
             work up.

        Exclusion Criteria:

          -  Use of more than two psychotropic medications (medications affecting behavior).

          -  Unstable dosing of any psychotropic medication (medication affecting behavior)

          -  Problems with kidney functioning

          -  Unstable seizure disorder

          -  Change in any anti-convulsant drug dosing in the 60 days prior to study entry

          -  Prior adequate treatment trial with acamprosate as determined by the study doctor

          -  Pregnant or lactating females
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 23 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Improved Factor VIII Inhibitor Evaluation

Eligibility criteria:
Inclusion Criteria:

          -  hemophilia A

          -  presence of inhibitory antibodies

        Exclusion Criteria:

          -  none
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: CONNECARE-Assuta-Case Study 1

Eligibility criteria:
Inclusion Criteria:

          -  All Maccabi members who arrive at the ER in an unplanned manner

          -  Age over 65

          -  Living in a home and not in a nursing home

          -  LACE> 7

          -  At least three of the following conditions:

               -  Multiple drugs - regular use of four or more drugs

               -  More than one case of hospitalization or visit to the ER in the past year

               -  Malnutrition

               -  Elements of low socio-economic status

          -  The patient and / or the main caregiver speak Hebrew, English or Russian

          -  The patient or primary caregiver has a password to the Maccabi Online website

          -  The patient and / or the primary caregiver have basic technological knowledge in the
             use of the applications

          -  The patient has wireless Internet access at home (via Wifi or through a cellular
             connection)

        Exclusion Criteria:

          -  Patients with cognitive or dementia problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)

Eligibility criteria:
Inclusion Criteria:

          -  Definite or probable disease - revise El Escorial criteria

          -  Normal blood tests

          -  Riluzole treatment during 1 month or more

          -  EMG in accordance with El Escorial criteria

        Exclusion Criteria:

          -  Other diseases (such as PNP)

          -  Both ADM muscles < 3 on MRC scale

          -  Conduction block on nerve conduction tests

          -  Disease duration > 3 years

          -  ALS-FRS < 25

          -  Forced vital capacity - <60%
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.

Eligibility criteria:
Inclusion Criteria:

          -  Patients undergoing acute or elective surgery for symptomatic PEH at Ersta Hospital
             and Karolinska University Hospital

        Exclusion Criteria:

          -  age below 18 years

          -  axial sliding hiatal hernia only (type I)

          -  missing informed consent

          -  previous hiatal hernia surgery

          -  American Society of Anesthesiologists (ASA) score IV or above

          -  achalasia

          -  Zollinger-Ellison syndrome

          -  malignant tumor

          -  inability or unwillingness to complete questionnaires
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction