Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study

Eligibility criteria:
Inclusion Criteria:

          -  at least 3 episodes of heartburn and/or regurgitation in a week for at least 3 months.

          -  evidence for an abnormal esophagal acid exposure on impedance-pH monitoring (tested in
             the last 2 years off PPI)

        Exclusion Criteria:

          -  gastric or esophagal surgery

          -  active peptic ulcer disease

          -  malignancy

          -  pregnancy

          -  uncontrolled diabetes mellitus

          -  severe cardiac conditions such as cardiac arrhythmia or ischemia or cardiac
             pacemaker/defibrillator

          -  allergy to adhesives/patches

          -  severe pulmonary disease

          -  obesity (BMI>30)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Survivin as Predictive Biomarker for RA

Eligibility criteria:
Inclusion Criteria:

          -  Patients seeking treatment at the primary health care for problems with their joints
             (pain, stiffness).

        Exclusion Criteria:

          -  Patients diagnosed with RA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of clinically possible, clinically probable laboratory-supported, clinically
             probable or clinically definite ALS (according to WNF EL Escorial diagnostic criteria,
             revised according to the AIRLIE House Conference 1998)

          -  Concomitant standard Riluzole therapy (50mg twice daily)

          -  patients included in ALS reference center

          -  women of childbearing age be non-lactating and surgically sterile or using a highly
             effective method of birth control and have a negative pregnancy test

          -  capable of thoroughly understanding all information given and giving full informed
             consent according to GCP

          -  Patients with gastrostomy

        Exclusion Criteria:

          -  evidence of major psychiatric disorder or clinically evident dementia precluding
             evaluation of symptoms

          -  any medical condition known to contre-indicate lithium treatment (dysthyroid,
             cardiopathy, renal insufficiency)

          -  presence of any concomitant life-threatening disease or impairment likely to interfere
             with functional assessment

          -  known hypersensitivity to any component of the study drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Human Epidermal Growth Factor Receptor 2 (HER-2) Status in Gastric and Gastro-Esophageal Junction (GEJ) Carcinoma

Eligibility criteria:
Inclusion Criteria:

          -  Tumor samples with histologically confirmed gastric or gastro-esophageal junction
             (GEJ) adenocarcinoma, any stage

          -  Samples with sufficient tumor material for centralized analysis

          -  Samples fixed and embedded in paraffin (formalin-fixed paraffin-embedded tissue
             [FFPET] samples).

        Exclusion Criteria:

        - Fixatives not allowed: Bouin's solution
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Between 45 to 70 years;

          -  Unilateral knee osteoarthritis according to clinical and radiological criteria

          -  Grade 2 or Grade 3 according to Kellgren-Lawrance Scale

          -  Right-handed according to Edinburgh Handedness Scale

          -  Chronic pain during the rest or activity above 4 points according to the Verbal Rating
             Scale

        Exclusion Criteria:

          -  Having neurological or psychiatric diseases

          -  Having chronic pain due to another pain disorder

          -  Having rheumatic diseases

          -  Using antidepressant medications or opioids

          -  Knee surgery within one year prior to the study

          -  Intraarticular injection and attend physical therapy within 6 months prior to the
             study

          -  Mini Mental State Examination Scale score below 24
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study

Eligibility criteria:
Inclusion Criteria:

          1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
             gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
             periods with heavy menstrual bleeding with a PBAC score greater than 100;
             menometrorrhagia is heavy vaginal bleeding occurring at irregular intervals.

          2. PBAC Score greater than 100 for 2 consecutive cycles

          3. Pelvic ultrasound that excludes pelvic pathology that can cause menorrhagia within 12
             months prior to study participation.

          4. Normal external genitalia examination within 6 months prior to study participation.

          5. Normal thyroid stimulating hormone (TSH) in the last 6 months prior to study
             participation.

          6. Negative urine or serum pregnancy test within 4 weeks prior to study participation.

        Exclusion Criteria:

          1. Presence of intra uterine device.

          2. Presence of a diagnosed bleeding disorder based on the standard work-up including
             complete blood count (CBC), prothrombin time, partial thromboplastin time, fibrinogen,
             von Willebrand panel and platelet function analysis (PFA-100) or platelet aggregation.

          3. Intake of medications with increased risk of bleeding

          4. Taking herbal products.

          5. Sexually active status.

          6. Body weight less than 40 kg.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 21 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems

Eligibility criteria:
Inclusion Criteria:

          -  Over 18 years of age

          -  At least one target chronic medical condition:

          -  arthritis

          -  asthma

          -  chronic obstructive lung disease

          -  diabetes

          -  heart failure

          -  or hypertension.

          -  Evidence of a behavioral problem or need:

          -  Diagnosis of:

          -  anxiety

          -  chronic pain including headache

          -  depression

          -  fibromyalgia

          -  insomnia

          -  irritable bowel syndrome

          -  problem drinking

          -  substance use disorder

          -  OR persistent use of certain medications used for behavioral concerns:

          -  antidepressants

          -  anxiolytics

          -  opioids

          -  antineuropathy agents

          -  OR persistent failure to attain physiologic control of a medical problem:

          -  blood pressure>165 while on 3 or more medications

          -  A1C > 9% for 6 months)

          -  OR the presence of three or more of the target chronic medical conditions.

        Exclusion Criteria:

          -  Not seeking care at a participating practice

          -  Inability to consent due to cognitive and/or developmental impairment/delays

          -  Living in the same household as a previously enrolled study participant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Follow Fever to Decide

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male or female,

          -  Between 18 and 40 years of age for the WP I and II phases, and between 18 and 80 years
             of age for the WP III phase,

          -  Having an BMI within the range [18.5; 24.9] kg/m² for the Work Package I and II
             phases, and between [18.5; 34.9] kg/m² for the Work Package III phase,

          -  Beneficiary of the social security,

          -  Provided informed consent for participation in the study.

        Exclusion Criteria:

          -  Presenting an acute pathology,

          -  Chronic pathology not followed and balanced,

          -  Having intestinal disorders (diverticles, disorders of the motility of the digestive
             tract, ...) or having undergone surgery at the gastrointestinal level,

          -  With known swallowing disorders,

          -  Having an alcohol dependence (more than 28 alcohol units per week), benzodiazepines or
             any illicit product,

          -  Smoking more than 5 cigarettes per day,

          -  Working nights or shift work,

          -  Simultaneous participation in other clinical research or participation in another
             clinical study for which the exclusion period has not ended.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Fragile X premutation carrier (CGG repeat 55-200)with neurological symptoms; Clinical
             FXTAS Stage 1-5

        Exclusion Criteria:

          -  Previous reaction to memantine
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction