Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: 1-Octanol to Treat Essential Tremor

Eligibility criteria:
INCLUSION CRITERIA:

        Patients with essential tremor with a history or ethanol responsiveness.

        Patients must be off any medications used to treat essential tremor such as mysoline or
        propranalol for at least 2 weeks.

        Patients must withhold ethanol and caffeine from 24 hours prior to starting the study until
        study termination (10 days).

        EXCLUSION CRITERIA:

        Patients with abnormalities on neurologic exam other than tremor.

        Patients with a history of chronic alcohol dependence.

        Patients with chronic medical conditions such as renal failure, hepatic failure and chronic
        lung disease.

        Patients on other chronic medications that cannot be temporarily discontinued for the
        length of the study (10 days).

        Patients, who for moral or religious reasons do not wish to take a potentially intoxicating
        drug.

        Patients with abnormalities on their baseline screening laboratory tests.

        Women who are pregnant or lactating.

        People of Asian decent who may differ pharmocogenetically with respect to alcohol and
        aldehyde dehydrogenase and may have increased sensitivity to alcohols and their metabolites
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Confocal Microscopy and Lacrimal Gland in Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  The Sjögren's syndrome diagnosis was made according to the revised American-European
             consensus criteria.

          -  Briefly, the patients had to have ocular and oral symptoms of dryness,

          -  clinically diagnosed dry eye and dry mouth disease,

          -  serum rheumatoid factor and antinuclear antibody levels ≥1:160,

          -  positive serology for anti SS-A or anti SS-B antibodies,

          -  labial salivary gland inflammatory infiltration focus score ≥2 and consents for
             lacrimal gland biopsy to be included into this study.

        Exclusion Criteria:

          -  Patients with any history of ocular surgery including punctal occlusion,

          -  other ocular or systemic disease

          -  or a history of topical/ systemic drug use or contact lens wear or

          -  other systemic disorders that would cause dry eyes or that would alter the ocular
             surface.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Evaluation of Clot Stability Induced by Solulin: Evaluation of New Solulin Mutants Lacking Protein C Activation Capacity

Eligibility criteria:
Inclusion Criteria:

          -  Patients with congenital blood disorder (hemophilia A and B),

          -  Inform consent

        Exclusion Criteria:

          -  Patients with acquired blood disorder.

          -  Allo-immunisation against blood coagulation factor concentrates (FVIII inhibitor)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: β-RELIEVED - REsponse in Acute fLare and In prEVEntion of episoDes of Re-flare in Gout - Extension 3 (E3)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have completed the second extension studies CACZ885H2356E2 or
             CACZ885H2357E2

          -  Patients treated with canakinumab in the core studies or subsequent extensions

        Exclusion Criteria:

        - Pregnant or nursing (lactating) women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Iron Repletion in Chronic Cough and Iron Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained cough : no detectable trigger for chronic cough identified, such as
             persistent rhinitis, chronic sinusitis, gastroesophageal reflux disease and asthma.

          -  no benefit by prior treatment with antiH1-histaminic drug and proton pump inhibitor.

          -  iron deficiency.

          -  normal lung function tests and chest radiography no relevant systemic disease.

          -  no acute respiratory infection in the last eight weeks.

          -  no pharmacological treatment in the last two weeks.

        Exclusion Criteria:
Female
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: An Open Label, Randomized, Balanced, Three Treatment, Parallel Design, Pharmacokinetic Study of Intranasal TBS-1 Administration to Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  Men with primary or secondary hypogonadism and a serum morning (0900 h ± 30 minutes)
             testosterone levels >100 ng/dl and ≤ 300 ng/dL.

          -  Normal Otolaryngological nasal endoscopy examination.

          -  Normal prostate examination (no palpable prostatic mass), and serum PSA ≤ 4.0 ng/mL.

        Exclusion Criteria:

          -  Current treatment with other androgens (i.e. DHEA), anabolic steroids or other sex
             hormones

          -  Treatment with Estrogens, GnRH antagonists, or Growth Hormone within previous 12
             months

          -  History of nasal surgery, specifically turbinoplasty, septoplasty, rhinoplasty, or
             sinus surgery.

          -  History of nasal disorders (e.g. polyposis, recurrent epistaxis ( > 1 nose bleed per
             month, abuse of nasal decongestants) or sleep apnea.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Trigger-point Blockade in Persistent Pain After Laparoscopical Groin Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Patients with persistent pain (< 6 mo) after laparoscopical groin hernia repair

          -  Patients with maximal pain area 3 cm or less from the superficial inguinal ring

          -  Patients living in the Capital Region of Denmark (Region Hovedstaden) or the Region of
             Zealand (Region Sjælland)

        Exclusion Criteria:

          -  Known allergy to bupivacaine or other local anesthetics of amide-type

          -  Declared incapable of making his/hers own affairs

          -  Does not comprehend Danish in writing or speech

          -  Cognitive impairment to a degree influencing the testing reliability

          -  Known recurrence of the inguinal hernia

          -  Other surgical procedures performed in the groin or on the external genitals

          -  Neuropathy affecting the groin region caused by other conditions, e.g. post-stroke,
             multiple sclerosis, herniated intervertebral disc

          -  Abuse of alcohol or drugs

          -  Unable to cooperate with the sensory examinations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Association Between Mitochondrial DNA Content and Risk of Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  1.histological confirmed gastric adenocarcinoma; 2.receiving surgical resection; 3.no
             preoperative anticancer treatment; 4.alive at least 1 months after surgery.

        Exclusion Criteria:

          -  1.history of other malignancy; 2.blood transfusion within one month or prior bone
             marrow transplantation; 3.patients who reluctant to sign informed consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Trial of Amivita in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria

          -  Patients must be men or women between the ages of 18 and 70 years

          -  Patient is clinical definite or probable ALS by the hospitals listed in the protocol

          -  Women who are of child bearing potential must have a negative pregnancy test

          -  Willing to comply with the study visits

          -  Will not take riluzole during the study period

          -  Be able to sign informed consent document

        Exclusion Criteria

          -  Myotonic dystrophy

          -  Myasthenia gravis

          -  Post-poliomyelitis syndrome

          -  Multifocal motor neuropathy with or without conduction block

          -  Hirayama disease

          -  Kennedy disease

          -  Hereditary spastic paraplegia

          -  Syringomyelia

          -  Spinal cord and brain stem tumors

          -  Paraneoplastic syndromes

          -  Severe liver or kidney disease disease

          -  Infection, severe diarrhea or vomiting

          -  Serious heart or lung diseases or malignant tumor history

          -  HIV infection

          -  Pregnancy or breastfeeding

          -  Have no ability to communicate

          -  Have participated in other clinical trials within 4 weeks

          -  Any form of substance abuse, psychiatric disorder, or other condition that, in opinion
             of the investigator, may interfere with the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment