Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Prognostic Factors Affecting Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  any male pt diagnosed as duchenne muscular dystrophy by typical clinical picture
             &shooting serum CPK level &EMG study or biopsy & age 10 to 18yrs old

        Exclusion Criteria:

          -  female patient ' age below 10 yrs old or above 18 yrs old .patient with autoimmune
             disease or malignancy
Male

Subject must be at least 10 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Increasing the Accessibility of a Falls Prevention Intervention for Community Dwelling Older Adults With Low Vision

Eligibility criteria:
Inclusion Criteria:

          -  60 and older;

          -  Visual impairment with some remaining reading ability.

        Exclusion Criteria:

          -  Less than age 60;

          -  Complete blindness;

          -  Vertebral osteoporosis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Efficacy and Safety Study of Norethindrone Acetate Transdermal Delivery System in Contraception

Eligibility criteria:
Inclusion Criteria:

          -  Healthy females

          -  18-45 years

          -  Regular, consistent menstrual cycles between 25 and 35 days

          -  Sexually active and at risk of becoming pregnant

        Exclusion Criteria:

          -  History of infertility

          -  Known contraindications to progestogen administration

          -  Pap smear suggestive of a high-grade precancerous lesion(s)

          -  Clinically significant deviation from normal in any of the screening tests or exams
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Endometrial Rejuvenation Study

Eligibility criteria:
Inclusion Criteria:

          1. Patients planning to undergo a frozen-thawed embryo transfer cycle using a single
             euploid blastocyst.

          2. Patients who have previously undergone at least 2 unsuccessful frozen-thawed embryo
             transfer cycles, defined as failure to achieve a clinical pregnancy (visualization of
             intrauterine gestational sac on ultrasound) or a cancelled embryo transfer cycle due
             to inadequate endometrial thickness.

          3. Patients with a diagnosis of thin endometrial lining (less than 6 mm maximum
             thickness) during at least one prior unsuccessful embryo transfer cycle.

          4. Initiation of the most recent unsuccessful frozen-thawed embryo transfer cycle with a
             thin endometrial lining must have occurred after January 1, 2017.

        Exclusion Criteria:

          1. Fewer than 2 prior unsuccessful frozen-thawed embryo transfer cycles.

          2. Most recent unsuccessful frozen-thawed embryo transfer prior to January 1, 2017.

          3. No euploid embryos available for transfer.

          4. Mullerian anomalies, excluding arcuate uterus

          5. Submucosal fibroids

          6. History of uterine surgery, excluding polypectomy, D&C, and Cesarean section

          7. Communicating hydrosalpinx without plans for surgical correction prior to study
             enrollment.

          8. Failure of patient to agree to enrollment in study with written consent.

          9. History of drug sensitivity or adverse reaction to AMD3100 (plerixafor).

         10. Pregnancy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Assessment of the Transfer of Using Levonorgestrel Intrauterine System (LNG IUS) as a Contraceptive to Using it as Part of Hormone Replacement Therapy (HRT).

Eligibility criteria:
Inclusion Criteria:

          -  Women with intact uterus, regular menstrual cycles and no previous or current
             climacteric symptoms.

        Exclusion Criteria:

          -  Pregnancy or lactation.

          -  Previous pelvic infections.

          -  Abnormal bleeding.

          -  Abnormal uterine cavity.

          -  Uterine polyps.

          -  Genital cancer.

          -  Liver diseases.

          -  Alcoholism or drug abuse.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 46 Years old.
Subject must be at most 51 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Sedation During Spinal Anesthesia

Eligibility criteria:
Inclusion Criteria:

          -  Male patients aged from 18 to 40 years old undergoing elective unilateral inguinal
             hernia repair with no neurological, cardiovascular and hepato-renal abnormalities.

        Exclusion Criteria:

          -  Age: younger than 18 or older than 40.

          -  Psychatric or neurological disorders.

          -  Cardiovascular disorders.

          -  Coagulation disorders.

          -  Contraindications to neuraxial block (allergy to L.A, peripheral neuropathy, prior
             spine surgery).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Validation of a Specific Measure for Assessment of Compliance With Treatment in Patients With Hemophilia

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hemophilia A and B

          -  Patients who have previously signed the informed consent document

        Exclusion Criteria:

          -  Patients with other congenital coaghulopatías (eg, Von Willebrand's disease)

          -  Patients with cognitive impairment, or oral or written understanding
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: A Comparison of Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst

Eligibility criteria:
Inclusion Criteria:

          -  Our analysis included boys who were younger than 17 years and possessing one-sided
             inguinal hernia, hydrocele, or cord cyst and who were otherwise healthy.

        Exclusion Criteria:

          -  Patients who had bilaterally inguinal hernia, hydrocele, or cord cyst
Male
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Glucocorticoid Withdrawal Syndrome in Patients With Treated Cushing Syndrome

Eligibility criteria:
Inclusion Criteria:

          1. age 18 and above,

          2. new diagnosis of CS of any of the three subtypes (pituitary, adrenal or ectopic CS),
             and MACS,

          3. planning for a curative surgery

          4. ability to provide informed consent.

        Exclusion Criteria:

          1. systemic supraphysiological GC for any reason within 1 month of enrollment, for more
             than 2 weeks,

          2. inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Assessment of Gastro-esophageal Reflux Using Endo-Flip vs Bravo

Eligibility criteria:
Inclusion Criteria:

          -  Provision of written, fully informed consent to undergo mechanistic procedures:
             Endo-FLIP, endoscopy and biopsy, 4 day wireless pH monitoring by the Bravo system

          -  All subjects should be off acid suppression medication (e.g. PPI, H2RA) for at least 5
             days prior to endoscopy

        Exclusion Criteria:

          -  Significant gastrointestinal symptoms or disease other than reflux

          -  Previous upper GI surgery or interventions such as oesophageal dilatations

          -  Predominant symptoms of motility disorders, e.g. dysphagia

          -  Presence of major oesophageal dysmotility on manometry, e.g. achalasia

          -  Significant co-morbidity requiring ongoing treatment or investigation

          -  Physical, neurological or psychiatric conditions preventing repeated visits to
             hospital or compliance with study procedures (e.g. physical impairment/reduced
             mobility)

          -  Pregnant at the time of enrolment

          -  No haematological abnormalities (no anticoagulants)

          -  No medications influencing gastrointestinal function within 3 days of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Physical Activity Level of Norwegian Boys With Duchenne Muscular Dystrophy

Eligibility criteria:
Inclusion Criteria:

          -  Boys with conclusive diagnosis of Duchenne Muscular disease, attending Norwegian
             pediatric rehabilitation clinics.

          -  Signed written consent

          -  Able to answer questionnaires with help from parents, care giver(s) or health care
             professional with regular follow up of the participants.

        Exclusion Criteria:

          -  Lack of consent.

          -  Language difficulties

          -  Cognitive dysfunction or mental retardation leading to difficulties in answering the
             questionnaires adequately
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment