Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: IGG Using in Laparoscopic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy

Eligibility criteria:
Inclusion Criteria:

          1. Age from 18 to 75 years

          2. Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
             poorly differentiated) confirmed pathologically by endoscopic biopsy

          3. cT2-4a, N-/+, M0 at preoperative evaluation according to the AJCC Cancer Staging
             Manual, 8th Edition

          4. No distant metastasis, no invasion of pancreas, spleen or other adjacent organs in the
             preoperative examinations

          5. Performance status of 0 or 1 on the ECOG (Eastern Cooperative Oncology Group) scale

          6. ASA (American Society of Anesthesiology) score I to III

          7. Written informed consent

        Exclusion Criteria:

          1. Women during pregnancy or breast-feeding

          2. Severe mental disorder

          3. History of previous upper abdominal surgery (except for laparoscopic cholecystectomy)

          4. History of previous gastric surgery (including ESD/EMR for gastric cancer)

          5. Enlarged or bulky regional lymph node (diameter over 3cm) supported by preoperative
             imaging.

          6. Other malignant disease within the past 5 years

          7. History of previous neoadjuvant chemotherapy or radiotherapy

          8. History of unstable angina or myocardial infarction within past six months

          9. History of cerebrovascular accident within past six months

         10. History of continuous systematic administration of corticosteroids within one month

         11. Requirement for simultaneous surgery for other disease

         12. Emergency surgery due to complication (bleeding, obstruction or perforation) caused by
             gastric cancer

         13. FEV1 (forced expiratory volume in one second)<50% of predicted values

         14. Diffuse invasive gastric cancer

         15. Preoperatively, tumors involving the squamocolumnar junction or duodenum were
             confirmed

         16. A history of iodine allergy

         17. Refuse laparoscopic surgery
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment