Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Adherence in Chronic Adrenal Insufficiency

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Patient's written informed consent

          -  Ability to comply with the protocol procedures

          -  Patients with chronic adrenal insufficiency under established stable replacement
             therapy

        Exclusion Criteria:

          -  Age < 18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          1. established diagnosis of definite ALS according to El Escorial criteria

          2. riluzole naive or stable dose for at least 2 months,

          3. life expectancy more than 2 years

          4. patients able to provide written informed consent.

        Exclusion Criteria:

          1. FVC less than 70%

          2. in case of primary bulbar paralysis less than 15 points on Norris bulbar scale,

          3. less than 15 points on Norris spinal scale,

          4. pregnancy, breastfeeding

          5. coagulopathy,

          6. skin infection at the site of bone marrow aspiration or application of the cell
             product,

          7. gastrostomy,

          8. any significant medical condition that would compromise the safety of the patient
             (e.g. recent myocardial infarction, congestive heart failure, renal failure, liver
             failure, cancer, systemic infection, recurrent thromboembolic disease .....),

          9. alcohol or drug abuse

         10. cancer.

         11. women of childbearing potential not using effective contraception (established oral
             contraception, intrauterine device, ligation of the uterine tube) including proven
             contraceptive measures taken by their sexual partners

         12. fertile men not using proven contraceptive measures including effective contraception
             of their partner (established oral contraception, intrauterine device, ligation of the
             uterine tube)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Interprofessional Dementia Care

Eligibility criteria:
Inclusion Criteria:

          -  70+ years

          -  PwD lives at home

          -  existing dementia diagnosis or screening result of DemTect <9

          -  caregiver: main caregiver of a PwD (Hauptversorgungsperson)

        Exclusion Criteria:

        - not able to provide written consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Cervical Mobility and Vestibular Rehabilitation

Eligibility criteria:
Inclusion Criteria:

          -  People from the age of majority (18 years) to 69 years, considered by the population
             division in youth, adults and older people to 69 years according to the World Health
             Organization (WHO) , of both genders, with commitment by diagnosed peripheral
             vestibular disorders clinically by a doctor, including the peripheral vestibular type
             Benign Paroxysmal Positional Vertigo (BPPV), with vestibular symptoms, with higher
             scores than or equal to a spot on the Visual Analogue Scale (VAS) Dizziness or higher
             rank than or equal to 16 points in the questionnaire dizziness Handicap Inventory
             (DHI).

        Exclusion Criteria:

          -  Elderly aged 70 or more, which have visual impairment and/or total hearing, orthopedic
             disorders that limit the realization of the proposed activities, nervous system
             injuries that cause damage engines and/or additional sensitive and diagnostics of
             Ménière's disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 72 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Bilateral Essential Tremor Treatment With FUS

Eligibility criteria:
Inclusion Criteria:

          -  Patients must be ≥ 18 years

          -  The patient has a primary diagnosis of ET or ET plus confirmed by a movement disorder
             neurologist;

          -  The patient previously underwent a MRgFUS (> 6 months ago);

          -  The tremor on the untreated side negatively impacts the patients' quality of life;

          -  The patient wants treatment of the contralateral side.

        Exclusion Criteria:

          -  Clinically relevant gait and/or balance impairment (e.g. wide-based, more than 2
             falls/months, wheelchair, walker, cane use)

          -  Clinically relevant speech impairment (e.g. impairment of intelligibility)

          -  Inability to comply with the follow-up schedule;

          -  Refusal of the treating physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein

Eligibility criteria:
Inclusion Criteria:

          -  Healthy males and females aged 6-60

        Exclusion Criteria:

          -  Known medical condition

          -  Use of inhaled, topical, or oral steroids

          -  Use of oral contraceptive pills or hormone replacement

          -  Menopause

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effect of Transcutaneous Electrostimulation (TENS) on Pain and Physical Function in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Men and women of at least 18 years of age

          -  Clinical or radiological diagnosis of knee OA according to the criteria of the
             American College of Rheumatology

          -  Knee pain lasting for six months or longer

          -  Radiographic evidence of at least one osteophyte at the tibiofemoral joint
             (Kellgren-Lawrence grade ≥ 2) or one or more of the following signs and symptoms in
             the knee; restricted range of motion, pain in motion, crepitations, morning stiffness

          -  Written informed consent

        Exclusion Criteria

          -  Patients diagnosed with rheumatoid arthritis or other musculoskeletal diseases
             affecting lower extremities

          -  Relevant effusion in the index knee

          -  Known current or remittent cancer

          -  Carry cardiac pacemaker or defibrillator in situ

          -  Knee surgery in previous 6 months

          -  Received treatment with arthrocentesis

          -  Intra-articular injection of steroids in previous 3 months

          -  Inability to understand instructions or to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Efficacy and Safety Study of the Combined Modality Therapy in Adenocarcinoma of the Esophago-gastric Junction

Eligibility criteria:
Inclusion Criteria:

          -  patients of both gender, aged more than 18, with histopathologically confirmed
             adenocarcinoma of the esophagogastric junction

          -  medically fit to undergo a major surgery with planned thoracotomy and in general
             condition allowing to tolerate chemo- or chemoradiotherapy (Karnofsky Performance
             Status ≥70, ECOG 0-1).

          -  Carcinoma of the esophagogastric junction defined as adenocarcinoma involving
             esophagogastric junction when its epicenter is localized within 5cm proximally or 5cm
             distally to the anatomical esophagogastric junction with subclassification to 3
             topographic types (type I between 5cm and 1cm above; type II between 1cm above and 2cm
             below; type III between 2cm and 5cm below anatomic junction of the esophagus and the
             stomach).

          -  Potentially resectable, local or locoregional cancer with clinical staging
             cT2-4aN0-3M0.

          -  The intended number of randomized patients has been set as 100: 50 patients randomized
             to each therapeutic arm with assumption, that 80% of randomized patients will complete
             the treatment protocol.

        Exclusion Criteria:

          -  disseminated cancer

          -  poor general condition (KI <70)

          -  adenocarcinoma of the stomach

          -  adenocarcinoma of the esophagus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Middle Cerebral To Umbilical Artery Doppler Ratio And Amniotic Fluid Volume Measurement In Post-date Pregnancies in King Khalid Military Central City

Eligibility criteria:
Inclusion Criteria:

          1. Singleton, viable fetus in the vertex presentation

          2. History of regular menstrual cycles

          3. Gestational age calculated from the first day of last menstryal period or by
             first-trimester or second-trimester (before 20 weeks) ultrasound examination

          4. No obstetric or medical complications of pregnancy apart from post-date pregnancy

        Exclusion Criteria:

          1. Patients unsure of their dates

          2. Medical disorders with pregnancy as (hypertension, diabetes mellitus or Rh
             isoimmunization)

          3. Prelabor rupture of membranes

          4. Polyhydramnios

          5. Women with multiple pregnancy

          6. Congenital fetal anomalies

          7. Antepartum hemorrhage

          8. Previus cesarean section

          9. Fetal malpresentation
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 48 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Different Amoxicillin Treatment Regimens in Erythema Migrans Patients

Eligibility criteria:
Inclusion Criteria:

          -  erythema migrans

        Exclusion Criteria:

          -  pregnancy

          -  extracutaneous manifestations of Lyme borreliosis

          -  immunocompromising state

          -  serious adverse event to beta lactam antibiotic

          -  receiving antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment