Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Predictors of Cardiovascular Risk in Covid-19 Patients During Acute Disease and at Short Term Follow-up

Eligibility criteria:
Inclusion Criteria:

          -  Positivity to the test for COVID-19 and / or chest Xray or CT positive for
             interstitial pneumonia compatible with infection with this virus, regardless of the
             severity of the infection and the need or not for hospitalization

          -  Informed consent freely granted also verbally

        Exclusion Criteria:

          -  Failure to satisfy the inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparison of Tracheal Intubation vs Laryngeal Mask Airway in Laparoscopic Total Extraperitoneal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

        Clinical diagnosis of unilateral inguinal hernia

        Exclusion Criteria:

        Clinical diagnosis of incarcerated inguinal hernia Clinical diagnosis of inguinal hernia
        with pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Not Invasive Monitoring of Pleural Drainage

Eligibility criteria:
Inclusion Criteria:

          -  patients with pleural effusion undergoing pleural drainage

          -  male and female patients aged at least 18 years

        Exclusion Criteria:

          -  pregnancy or breast feeding

          -  implanted pacemaker / Cardiac Resynchronization Therapy (CRT) / Implanted Cardioverter
             Defibrillator (ICD) except Medtronic Device "OptiVol".

          -  patients not being able to consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Bindex for Osteoporosis Diagnostics

Eligibility criteria:
Inclusion Criteria for all:

          -  Postmenopausal status

          -  Age at 50 years or over

          -  Caucasian or Hispanic race (number shall be controlled, 140 in each group)

          -  Body mass index (BMI < 35)

        Additional criteria for Osteoporotic group

        - T-Score (NHANES database) -2.5 or lower at femoral neck or total femur

        Additional criteria for non-osteoporotic group

        - T-Score (NHANES database) > -2.5 at femoral neck or total femur

        Exclusion Criteria:

        for non-osteoporotic groups (Hispanic or Caucasian)

          -  Previous osteoporosis diagnosis

          -  Previous or current use of anti-fracture medication
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Collection and Analysis of the Clinical and Biological Characteristics of Patients Treated for Giant Cells ARTEitis (Horton's Disease)

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 45 years or older

          -  Patients with giant cell arteritis according to ACR criteria or revised criteria
             incorporating imaging parameters,

          -  Patients managed at the University Hospital of Carémeau in Internal Medicine from
             01/01/2011 to 01/01/2020.

        Exclusion Criteria:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Role of Proteomics in Diagnosing Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of pulmonary sarcoidosis stage I-IV

        Exclusion Criteria:

          -  Non-smoking

          -  No treatment for extra-pulmonary symptoms of sarcoidosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Impact of Bloodletting on Iron Metabolism in Type 1 Hemochromatosis

Eligibility criteria:
Inclusion Criteria:

          -  Men

          -  Age 18 years or older

          -  Homozygosity for the C282Y mutation of the HFE gene

          -  With an indication of treatment by bloodletting (in accordance with the French HAS
             guidelines)

          -  Ferritinemia ≥ 500µg/L

          -  Transferrin saturation ≥ 75%

          -  Never treated by bloodletting

          -  Written informed consent

        Exclusion Criteria:

          -  Contraindication to bloodletting

          -  Chronic inflammatory or dysmetabolic or neoplastic disease

          -  Major cardiovascular disease

          -  Excessive consumption of alcohol (≥ 3gr/day)

          -  Treatment by iron chelators, C or E vitamins

          -  Stay in altitude> 1500m in the month preceding the period Day 1

          -  Patients under guardianship

          -  Blood donation in the 3 past months

          -  Night / shift workers
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  Children aged 8-18 who are overweight or at risk for overweight (defined as BMI
             >85%ile for age and gender referred for evaluation and treatment of sleep apnea.

        Exclusion Criteria:

          -  Children with underlying craniofacial anomalies, chromosomal abnormalities,
             neuromuscular disorders and metabolic disorders except diabetes will be excluded.
             Children and parents who do not speak or write English will be excluded. Children with
             neuropsychiatric disabilities severe enough to preclude sufficient cooperation with
             overnight polysomnography will also be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Neuromodulation Techniques in the Treatment of Chronic Tinnitus With Hearing Loss

Eligibility criteria:
Inclusion Criteria:

          -  chronic tinnitus

          -  hearing loss

        Exclusion Criteria:

          -  neurological diseases

          -  use of drugs affecting the central nervous system

          -  evidence of dementia

          -  clinical diagnosis of depression
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: BAY81-8973 Pediatric Safety and Efficacy Trial

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  PTPs (previously treated patients): aged <= 12 years

          -  PUPs (previously untreated patients) / MTPs (minimally treated patients): aged < 6
             years

          -  Severe hemophilia A defined as < 1% FVIII concentration (FVIII:C)

          -  PTPs: >= 50 exposure days (EDs) with any FVIII concentrate, no current evidence of
             inhibitory antibody, and no history of FVIII inhibitor formation

          -  PUPs: no prior exposure to any FVIII product

          -  MTPs: having no more than 3 EDs with any FVIII product, no current evidence of
             inhibitory antibody and no history of FVIII inhibitor formation

        Exclusion Criteria:

          -  With another bleeding disorder that is different from Hemophilia A

          -  With thrombocytopenia (platelet count < 100 000/mm^3)

          -  Creatinine > 2x upper limit of normal or Aspartate aminotransferase (AST)/Alanine
             aminotransferase (ALT) > 5x upper limit of normal

          -  Without a negative inhibitor testing at screening (except for PUPs)

          -  Receiving chemotherapy, immune modulatory drugs, has received another investigational
             FVIII product within the last month, or received another experimental drug within the
             last 3 months

          -  Requires any pre-medication to tolerate FVIII treatment

          -  Known hypersensitivity to active substance, mouse, or hamster protein
Male
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Extended Clomiphene Citrate Regimen in Women With Polycystic Ovary Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Age: between 18-35 years

          -  Period of infertility > 2 years

          -  Serum level of FSH <10 U/L in the early follicular phase

          -  All women were CC-resistant PCOS, as they failed to ovulate with a dose of CC of 150
             mg/day for 5 days per cycle for at least three consecutive cycles

          -  All women had patent Fallopian tubes proved by hysterosalpingography or laparoscopy
             and their partners satisfied the normal parameters of semen analysis according to the
             modified WHO criteria

        Exclusion Criteria:

          -  Infertility due to causes other than CC- resistant PCOS or due to combined factors

          -  Body mass index (BMI) ≥35 Kg/m²

          -  The use of metformin, gonadotropins, hormonal contraception or diet regimen within the
             last 6 months

          -  Women with congenital adrenal hyperplasia, hyperprolactinaemia or abnormal thyroid
             function

          -  Hypersensitivity or contraindications to Letrozole or clomiphene treatment

          -  Previous LOD
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction