Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: FSH/LH Ratio as a Predictor of IVF Outcome in Young and Older Women

Eligibility criteria:
Inclusion Criteria:

          -  less than 41 years old , with normal menstrual cycle with a range of 24 - 35 days with
             day 3 FSH less than 10 mIU/ml in natural cycle and normal serum prolactin . All women
             had normal uterine cavity determined by previous hysterosalpingography or hysteroscopy

        Exclusion Criteria:

          -  Women with abnormally low Gn as hypothalamic hypogonadism , High LH as PCOS and women
             with abnormal endocrine functions as abnormal thyroid or adrenal functions were
             excluded. Any woman with ovarian cyst or azopermic male partner was also excluded.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Randomized Study of the Effects of Glucose on Cognition in Healthy Young and Elderly People and Parkinson's Disease Patients

Eligibility criteria:
Inclusion Criteria:

          -  Three groups of subjects are eligible for this study: Healthy young adults between
             ages 18 and 30; Healthy elderly adults between ages 60 and 90; AND Anyone diagnosed
             with Parkinson's disease

        Exclusion Criteria:

          -  Prior surgery to remove part of the stomach

          -  Diabetes, Addison's, or Cushing's diseases
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Quantitative Assessment of Distal Radioulnar Joint Stability With Pressure-Monitor Ultrasonography

Eligibility criteria:
Inclusion Criteria:

          -  healthy volunteers

          -  DRUJ instability patients

        Exclusion Criteria:

          -  the participants who had a history of previous wrist trauma and wrist pain will be
             excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Nab-paclitaxel Combined With S-1 Treating Diffuse Type of Stage Ⅲ Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  gastric cancer patients after radical resection

          -  diffuse type gastric cancer stage III

        Exclusion Criteria:

          -  Patients who have metastasis disease

          -  Patients who can not tolerate chemotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Resveratrol for the Treatment of Non Alcoholic Fatty Liver Disease and Insulin Resistance in Overweight Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  13 to <18 years of age

          -  BMI considered overweight (BMI > 25 kg/m2 ) or obese (BMI > 30 kg/m2 )

          -  Confirmed 1H-MRS defined hepatic steatosis (>5.5% fat/water)

          -  Parent/Guardian willing and able to provide written, signed informed consent, and
             subjects willing to co-sign parental consent

          -  Sexually active subjects must be willing to use an acceptable method of contraception

          -  Females of child bearing potential must have a negative pregnancy test at screening.

        Exclusion Criteria:

          -  The use of any chronic medications with the exception of oral birth control and
             natural health products with the exception of multivitamins.

          -  Adolescents with altered insulin sensitivity or tissue lipid content unrelated to
             obesity and the metabolic syndrome, including:

        type 2 diabetes; present or previous malignancy renal disease, hypertension (anyone who has
        BPs over the 99th percentile for age and gender) or liver disease;

          -  significant weight loss (10% in last six months) or enrolled in weight loss program in
             the six months prior to the study;

          -  self-reported history of alcohol consumption of greater than two drinks per day and/or
             drinking alcohol more than once weekly;

          -  report using non-prescription recreational drugs;

          -  allergies or sensitivities to any of the ingredients in the investigational product or
             placebo;

          -  females breastfeeding at screening or planning on becoming pregnant at any time during
             the study;
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Comparison of Salivary and Serum Free Testosterone in Normal and Hypogonadal Men

Eligibility criteria:
Inclusion Criteria:

          -  Normal male subjects aged 20-65 years

        Exclusion Criteria:

          -  Women Smokers, HIV positive, diabetes, hepatatis C positive, subjects currently taking
             testosterone who are unwilling to suspend use for teh duration of the trial, subjects
             taking aldactone or medicines that may interfere with the protocol
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Gracie Diet for Gastroesophageal Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or older at registration.

          -  Patients with ongoing symptoms of GERD: heartburn (pyrosis) mid-sternal chest pain,
             regurgitation of fluid or food, development of esophageal inflammation that may lead
             to swallowing dysfunction, or extraesophageal manifestations (i.e. cough,
             bronchospasms, and hoarseness).

          -  Use of one of the following PPI medications: omeprazole, lansoprazole, pantoprazole,
             rabeprazole, esomeprazole or dexlansoprazole. And/or use of one of the following H2
             blockers medications as well: famotidine, cimetidine, ranitidine or nizatidine.

          -  Willing to comply with the Gracie diet regimen

        Exclusion Criteria:

          -  Age < than 18 years.

          -  Patients unable to speak English.

          -  Pregnancy or nursing.

          -  Complicated oropharyngeal dysphagia or other condition with risk for aspiration from
             oral ingestion.

          -  Exclusion of other causes of symptoms as mechanical gastrointestinal obstruction,
             Barrett's esophagus and cancer of the esophagus by standard radiographic or endoscopic
             test evidenced in the medical record chart.

          -  A prior surgery of the upper gastrointestinal tract.

          -  Failure to give informed consent.

          -  Any other condition, which in the opinion of the investigator would impede compliance
             or hinder the completion of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors

Eligibility criteria:
Inclusion Criteria:Male and female patients ages 18 years and older who are referred to the
        Division of Gastroenterology at the Dallas VA Medical Center for the evaluation of
        heartburn that is refractory to PPI therapy

        Exclusion Criteria:

          1. Patients unwilling or unable to provide informed consent.

          2. Allergy to lansoprazole.

          3. Patients taking warfarin.

          4. Coagulopathy that precludes safe biopsy of the esophagus.

          5. Comorbidity that precludes safe participation in the study.

          6. Pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Study About Patients Using Copper Intrauterine Device

Eligibility criteria:
Inclusion Criteria:

          1. Regularly menstruating women before CIUD insertion.

          2. Age between 18 and 35 years.

          3. Hormonal treatment has not been taken at least two months before the study.

          4. Non steroidal anti-inflammatory drugs has not been taken 24 hours before the
             examination.

        Exclusion Criteria:

          1. Pregnancy.

          2. The presence of pelvic pathology as ovarian cysts, pelvic endometriosis, endometrial
             polyps or fibrosis.

          3. Present or past history of pelvic inflammatory disease.

          4. Patients on hormonal treatment in the last two months before the study.

          5. Patients on non steroidal anti-inflammatory drugs last 24 hours before the
             examination.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women

Eligibility criteria:
Inclusion Criteria:

          -  Women with osteoporosis who already use bisphosphonates.

          -  Women with osteoporosis who are not under bisphosphonates yet, or are not indicated
             for such therapy.

          -  Women with osteopenia either using or not bisphosphonates.

        Exclusion Criteria:

          -  Women with bone diseases other than osteoporosis or osteopenia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Comparison of 3 Diagnostic Strategies of PE: Planar V/Q Scan, CTPA, and V/Q SPECT.

Eligibility criteria:
Inclusion Criteria:

          -  Outpatients with a clinically suspected PE (defined as an acute onset of new or
             worsening shortness of breath, chest pain, hemoptysis, presyncope, or syncope) without
             another obvious apparent cause.

          -  High pretest clinical probability of PE or a non-high pretest clinical probability but
             a positive D-Dimer test.

        Exclusion Criteria:

          -  Age less than 18 years

          -  Patients with already confirmed PE

          -  Patients with a clinically suspected high-risk pulmonary embolism (hypotension or
             shock)

          -  Use of therapeutic doses of anticoagulants for more than 48 hours

          -  Other indication for long-term use of anticoagulants

          -  Contraindication to contrast media (including renal insufficiency with a creatinine
             clearance lower than 30 ml/min)

          -  Life expectancy less than 3 months

          -  Unable/unwilling to give informed consent

          -  Unlikely to comply with study follow-up

          -  Ongoing pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction