Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: LIWA for Treatment of Alzheimer Patients

Eligibility criteria:
Inclusion Criteria:

          1. Men and women aged 50-85.

          2. Diagnosed with Alzheimer's disease for at least half a year (by the DSM-IV criteria).

          3. Scored 16-26 on the MMSE.

          4. Received drug therapy for their disease, with each treatment having been administered
             at an acceptable dosage for at least 5 weeks.

          5. Existence of a routine therapist for changes or adverse effects reports.

          6. Existence of Alzheimer diagnosis by CT or MRI tests.

          7. Answered in the negative to all questions in the pre-TMS treatment safety
             questionnaire.

          8. Gave their oral and written consent to participate in the trial.

        Exclusion Criteria:

          1. An additional neurological disorder.

          2. Severe psychiatric disorder.

          3. Uncontrolled hypertension, beyond 170/110.

          4. History of epilepsy, seizure, or heat convulsion or History of epilepsy or seizure in
             first degree relatives.

          5. History of head injury or stroke.

          6. History of metal implants in the head (except dental fillings)or History of surgery
             entailing metallic implants or known history of any metallic particles in the eye,
             implanted cardiac pacemaker, cochlear implants, use of neuro stimulators, or any
             medical pumps.

          7. History of migraines in the last six months.

          8. History of drug or alcohol abuse.

          9. Inadequate communication with examiner.

         10. Participation in another clinical study, either concurrent with this trial or in the 3
             months preceding it.

         11. Inability to sign a consent form.

         12. Leukemia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment