Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Cervical Electrical Stimulation for ALS

Eligibility criteria:
Inclusion Criteria:

          -  Age between 21 and 75 years

          -  Diagnosis of probable or definite ALS (or non-disabled volunteer)

          -  Incomplete weakness of left or right wrist or hand muscles:

               -  score of 2, 3, or 4 (out of 5) on manual muscle testing of:

               -  wrist flexion

               -  finger extension

               -  finger flexion

               -  or finger abduction

          -  Detectable F-wave responses of the left or right APB to median nerve stimulation
             and/or ADM to ulnar nerve stimulation

          -  US Veteran or non-Veteran

        Exclusion Criteria:

          -  History of other serious injury or disease of central or peripheral nervous system

          -  History of seizures

          -  Ventilator dependence or patent tracheostomy site

          -  Use of medications that significantly lower seizure threshold

          -  History of head trauma with evidence of brain contusion or hemorrhage or depressed
             skull fracture on prior imaging

          -  History of implanted:

               -  brain/spine/nerve stimulators

               -  aneurysm clips

               -  ferromagnetic metallic implants

               -  or cardiac pacemaker/defibrillator

          -  Significant coronary artery or cardiac conduction disease

          -  History of bipolar disorder or suicide attempt or active psychosis

          -  Heavy alcohol consumption (> equivalent of 5 oz of liquor) within previous 48 hours

          -  Open skin lesions over the face, neck, shoulders, or arms

          -  Pregnancy

          -  Unsuitable for study participation as determined by study physician
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Prospective Study With FLOT in Patients With Locally Advanced, Limited Metastatic or Extensive Metastatic Adenocarcinoma of the Stomach or Esophagogastric Junction

Eligibility criteria:
Inclusion Criteria:

          -  Metastatic or locally advanced gastric cancer or adenocarcinoma of the esophagogastric
             junction

          -  No prior chemotherapy in metastatic state

          -  Adequate blood and biochemistry parameters

        Exclusion Criteria:

          -  Hypersensitivity for 5-FU, Leucovorin, Oxaliplatin or Docetaxel

          -  KHK, cardiomyopathy or cardiac insufficiency

          -  Malignancy <5 years ago

          -  Brain metastases

          -  Severe internal disease or inadequate blood and biochemistry parameters

          -  Pregnancy and lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: An RCT of 19G EBUS-TBNA Needle in Suspected Sarcoidosis

Eligibility criteria:
Inclusion Criteria: All the following

          -  Age at least 18 years

          -  Clinicoradiological suspicion of sarcoidosis where EBUS-TBNA is being planned

          -  Enlarged bilateral hilar and/or mediastinal lymph nodes >10 mm (any axis) on computed
             tomography of the chest

          -  Ability to provide informed consent to participate in the study.

        Exclusion Criteria: Patients with any of the following will be excluded

          -  Asymmetric lymph nodes

          -  Lymph nodes with significant hypodense areas suggestive of necrosis

          -  Tuberculin skin test >10 mm

          -  Hypoxemia (SpO2 <92% on FiO2 of 0.3)

          -  Treatment with systemic glucocorticoids for >2 weeks in the preceding three months

          -  Diagnosis of sarcoidosis possible with another minimally invasive technique such as
             skin biopsy or peripheral lymph node biopsy

          -  Failure to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Microenvironment and Male Fertility

Eligibility criteria:
Inclusion Criteria:

          -  Men diagnosed with infertility who consent to participate in the study

        Exclusion Criteria:

          -  Prior hormone replacement therapy

          -  Antibiotic use in past 6 months

          -  Inability to consent for self, due to age or mental capacity

          -  Infertility attributable to identifiable causes other than hypogonadism
Male

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Control Ovarian Stimulation Timing Test

Eligibility criteria:
Inclusion Criteria:

          -  female Infertility

        Exclusion Criteria:

          -  PCO (polycystic ovary) syndrome women over 42 male factor resulting in sperm samples
             less than 5 millions motile.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 42 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: The Short-term Effects of Instrument-Based Mobilization Compared With Manual Mobilization for Low Back Pain: A Randomized ClinicalTrial

Eligibility criteria:
Inclusion Criteria:

          -  age 20-59 years (commonly affected age range), BMI 18.5-30 kg/m2 (normal to
             overweight), localized NLBP, pain duration <12 months, and pain score ≥3/10 on the
             NPRS.

        Exclusion Criteria:

          -  history of spinal surgery, significant previous back trauma, spinal or lower-extremity
             deformities, LBP associated with peripheral neurological symptoms (paraesthesia,
             anaesthesia, signs of nerve root compression), neurological diseases, systemic
             diseases (diabetes mellitus, rheumatoid arthritis), and any contraindication to manual
             therapy (spinal instability, healing fracture, dislocations, pregnancy in women).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 59 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: X-chromosome Inactivation, Epigenetics and the Transcriptome

Eligibility criteria:
Controls should fore fill the criteria below

        Inclusion Criteria:

          -  Healthy

          -  Age matched

        Exclusion Criteria:

          -  Any chronic or acute illness thought to influence the outcome measures
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of mixed hyperlipidemia

          -  At least 18 years of age

        Exclusion Criteria:

          -  Women who are pregnant or lactating, or planning to become pregnant.

          -  Subjects with a clinically indicated need for statin (HMG-CoA reductase inhibitor)
             therapy other than atorvastatin or other concomitant therapy with known lipid altering
             effects on LDL-C and HDL-C including fibrates and nicotinic acid (high doses)

          -  Subjects taking any drugs known to be associated with an increased risk of myositis in
             combination with HMG-CoA reductase inhibitors

          -  Subjects with any other medical condition or laboratory abnormality which could affect
             subject safety, preclude evaluationof response, or render unlikely that the subject
             would complete the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Esophageal and Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux

Eligibility criteria:
Inclusion Criteria

          -  GERD 1. Documented erosive esophagitis (Patients will be newly diagnosed with
             esophageal erosion at initial visit via esophagogastroduodenoscopy [EGD]) 2.Patients
             with non-erosive esophagitis who have been responsive to PPI

          -  LPR 1. Diagnosed via Head & Neck Institute endoscopists (i.e. patients will be newly
             diagnosed at initial visit via laryngoscopy)

          -  Controls

               1. No complaints or history of heartburn, acid regurgitation, atypical chest pain

               2. Never been seen by GI or ENT for related symptoms

               3. No prior therapy for GERD

               4. Have a medical condition other than reflux for which they need to undergo EGD.
                  These conditions can be diarrhea, peptic ulcer disease, malabsorption, anemia,
                  and dysphagia.

        Exclusion Criteria

          -  Age < 18yrs

          -  Pregnancy

          -  Patients with contra-indications for EGD

          -  Use of antacid (PPI, H2RB) within last 30 days

          -  Use of any/all medications affecting gastrointestinal motility

          -  Known history of: Barrett's esophagus, Peptic stricture, Pyloric stenosis, Gastric
             resection

          -  Patients unable to give informed consent

          -  Patients unable to comply with follow-up

          -  Contraindications to biopsy: Taking anticoagulants other than aspirin (Coumadin,
             Plavix) or allergies to local anesthetic.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans

Eligibility criteria:
Inclusion Criteria:

          -  typical solitary erythema migrans as defined by the United States Centers for Disease
             Control and Prevention. In addition, patients with skin lesion <5 cm in diameter were
             also included if they recalled a recent tick bite at the site of the skin lesion, had
             a symptom-free interval between the bite and the onset of the lesion, and reported an
             expanding skin lesion prior to diagnosis.

        Exclusion Criteria:

          -  Lyme disease previously

          -  pregnancy or lactation

          -  immunocompromised

          -  serious adverse reaction to a beta-lactam or tetracycline drug in the past

          -  received an antibiotic with known anti-borrelial activity within 10 days

          -  multiple erythema migrans lesions

          -  presence of an extracutaneous manifestation of Lyme disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment