Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Genetic Basis of Rosacea

Eligibility criteria:
Eligibility Criteria for Rosacea Group:

        Inclusion criteria for rosacea participants:

          1. Clinical signs and symptoms of rosacea (papulopustular or erythrotelangiectatic
             subtypes) present at enrollment as determined by the investigator

          2. All four grandparents of European descent

          3. Fitzpatrick skin type I or II

          4. Age 18 years or older

        Exclusion criteria for rosacea participants:

          1. Unable or unwilling to provide written informed consent

          2. Concomitant facial or medical condition that obscures diagnosis of rosacea (such as
             malar erythema from lupus erythematosus)

          3. Acne vulgaris

          4. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

          5. Inability for investigator to verify rosacea diagnosis on clinical examination due to
             rosacea treatment(s) leading to complete lack of signs and symptoms (such prior laser
             treatments, systemic tetracycline usage, etc.)

          6. Use of topical prescription medications or procedures to the face within one month of
             enrollment

          7. Women who are pregnant or lactating

        Eligibility Criteria for Non-Rosacea Group:

        Inclusion criteria for control participants:

          1. No history of rosacea

          2. No clinical signs or symptoms of rosacea

          3. No family history of rosacea

          4. All four grandparents of European descent

          5. Fitzpatrick skin type I or II

          6. Age 18 years or older

        Exclusion criteria for control participants:

          1. Unable or unwilling to provide written informed consent

          2. Acne vulgaris

          3. Unable or unwilling to provide peripheral blood sample (a few teaspoons)

          4. Women who are pregnant or lactating

          5. Use of topical prescription medications or procedures to the face within one month of
             enrollment

          6. Skin conditions that might interfere with interpretation of procedure results (at the
             discretion of the investigator)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment