Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: The Pathogenesis of Idiopathic Dry Eyes

Eligibility criteria:
Inclusion Criteria:

        Healthy Controls:

        Female over the age of 18, No symptoms of dry eyes, Must be able to read text on the
        computer screen and understand English, and not have a physical impairment that prevents
        you from completing a paper and pencil questionnaire or using a tablet computer

        Fibromyalgia:

        Female over the age of 18, No symptoms of dry eyes, Been diagnosed with fibromyalgia, Must
        be able to read text on the computer screen and understand English, and not have a physical
        impairment that prevents you from completing a paper and pencil questionnaire or using a
        tablet computer

        Dry Eye:

        Female over the age of 18, have symptoms of dry eyes, Must be able to read text on the
        computer screen and understand English, and not have a physical impairment that prevents
        you from completing a paper and pencil questionnaire or using a tablet computer

        Exclusion Criteria:

        Pregnant or breast feeding, use of medicated eye drops in last month (Artificial tears ok),
        diagnosis of autoimmune or rheumatologic disease (e.g. rheumatoid arthritis, crohn's
        disease, lupus, multiple sclerosis, etc), heart condition requiring daily medications (e.g.
        angina, congestive heart failure), COPD or asthma requiring daily inhalers (rescue inhalers
        ok), history of cancer in the past 2 years (skin cancer is ok), use of oral antihistamine
        medications (e.g. benadryl, claritin, clarinex, zyrtec, allegra, etc), use of oral
        anticholinergic medications (e.g. scopolamine, ditropan, detrol, ipratropium, etc)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction