Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: A Clinical Trial to Evaluate the Safety and Efficacy of Traditional Chinese Medicine in Sjögren's Syndrome.

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥20 years old

          -  Written informed consent obtained

          -  Been diagnosed with the diagnostic criteria for Sjogren's syndrome (according to the
             2002 European Classification Standard)

          -  The ESSPRI score of the patient of Sjogren's syndrome at least> 3

        Exclusion Criteria:

          -  Have association disease about heart, lung, nerve or mental

          -  Pregnant or breastfeeding women

          -  Laboratory abnormality:

               1. Serum creatinine ≥2.0 mg/dl

               2. Male: Hb≤9 g/dl;Female: Hb≤8.5 g/dl

               3. Neutrophil or lymphocyte<0.5 x 109/l
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Oral T7 Oral Testosterone in Man

Eligibility criteria:
Inclusion Criteria:

          -  Males between 18 and 50 years of age

          -  In good health based on normal screening evaluation (consisting of a medical history,
             physical exam normal serum chemistry, hematology, and baseline hormone levels.

          -  Must agree to not participate in another research drug study

          -  Must agree to not donate blood

          -  Must be willing to comply with the study protocol and procedures

        Exclusion Criteria:

          -  Men in poor general health, with abnormal blood results (clinical laboratory tests or
             hormone values)

          -  A known history of alcohol or drug abuse

          -  Participation in a long-term male contraceptive study within the past month

          -  History of bleeding disorders or current use of anti-coagulants

          -  History of sleep apnea

          -  History of major psychiatric disorder

          -  Body mass index > 37

          -  Infertility

          -  Hematocrit > 55 or < 30

          -  PSA >4
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Study Of Axitinib In Combination With Cisplatin And Capecitabine In Patients With Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  confirmed diagnosis of stomach cancer

          -  advanced stomach cancer of stage IV

          -  adequate blood chemistry, blood counts and kidney function

          -  willing to participate to study requirements and sign an informed consent document

        Exclusion Criteria:

          -  prior chemotherapy for stomach cancer in its advanced stage

          -  excessive toxicities related to prior therapies

          -  pregnant or breastfeeding patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Screening Questionnaire for Respiratory Muscle Weakness and Sleep-disordered Breathing in Neuromuscular Disorders

Eligibility criteria:
Inclusion Criteria:

          -  proven neuromuscular disease known to be potentially associated with diaphragmatic
             weakness (group 1)

          -  newly diagnosed obstructive sleep apnea with an apnea hypopnea index > 15/h total
             sleep time (group 2)

          -  newly diagnosed narcolepsy, hypersomnia, insomnia or parasomnia in the absence of any
             sleep-related breathing disorder (group 3)

          -  availability of recent diagnostic sleep studies including polysomnography and
             transcutaneous capnography

        Exclusion Criteria:

          -  ongoing CPAP oder non-invasive ventilation

          -  inability to participate in study procedures

          -  severe lung disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Retrospective Chart Review to Evaluate Safety and Tolerability of ADVATE Among Previously Untreated Patients in China With Moderate to Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Previously untreated patient (PUP) in China with moderate to severe hemophilia A.

          2. Investigator prescribed ADVATE as the predominant therapeutic agent for the management
             of hemophilia A

          3. Informed consent form from patient and/or legal representative will need to be signed
             per local regulation

        Exclusion Criteria:

          1. Presence of an inherited or acquired hemostatic defect other than hemophilia A, and
             any other clinically significant chronic disease

          2. Participants who participated in another investigational FVIII drug study, or had
             participated in any clinical study involving an investigational FVIII drug during the
             course of the observation period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Study of 0444 Gel in the Treatment of Inflammatory Lesions of Rosacea

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of rosacea

          -  Good health with the exception of rosacea

          -  Papsules and pustules minimum and maximum requirements

        Exclusion Criteria:

          -  Subjects who are pregnant, nursing, or planning a pregnancy within the study
             participation period.

          -  Subjects who have any systemic or dermatological disorders with the exception of
             rosacea
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Men

          -  Congenital hypogonadism

          -  Treatment Naive

        Exclusion Criteria:

          -  Previous history of androgen replacement

          -  Hypertension

          -  Diabetes mellitus
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 26 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Comparison of Desloratadine Associated With Prednisolone Oral Solution Versus Dexchlorpheniramine Associated With Betamethasone for Cutaneous Rash Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Consent of the patient or legal guardian;

          -  Clinical diagnosis of acute cutaneous rash defined by the presence of erythematous
             papules on healthy skin, different sizes, itchy and fleeting

          -  Children aged between 2 and 11 years and 11 months (up to 30 kg);

        Exclusion Criteria:

          -  Participation in clinical trial in 30 days prior to study entry;

          -  Patients with history of hypersensitivity to desloratadine or prednisolone or with
             corticosteroids use contraindications ;

          -  Patients with any clinically significant disease other than cutaneous rash including
             hematopoietic, cardiovascular, renal, neurological, psychiatric or autoimmune
             disorders;

          -  Patients on treatment with monoamine oxidase inhibitors (MAOIs);

          -  Patients diagnosed with other dermatoses
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Nitric Oxide Donor Isosorbide Mono Nitrate for Induction of Labor With Pre-labor Rupture of Membranes

Eligibility criteria:
Inclusion Criteria:

          -  Singleton pregnancy.

          -  Cephalic presentation.

          -  Bishop score < or = 6.

          -  Average size of the fetus.

          -  Adequate pelvic dimensions.

          -  Prelabour rupture of membranes.

          -  Term or post-term pregnancies with an indication for labor induction either maternal
             or fetal.

        Exclusion Criteria:

          -  Previous uterine scar (e.g. caesarian delivery or unknown uterine incision , previous
             hysterotomy or myomectomy of the uterine corpus involving entry of the uterine cavity
             or extensive myometrial dissection, previous uterine rupture)

          -  Patients with regular uterine contractions.

          -  Malpresentation.

          -  Multifetal gesta1tion.

          -  Established fetal distress ( e.g. thick meconium stained liguor or non reassuring CTG
             changes)

          -  Indication for CS, e.g. Major degree of cephalopelvic disproportion and fetal
             macrosomia.

          -  Placenta previa or vasa previa.

          -  Active genital herpes infection.

          -  Severe maternal illness (e.g. severe preeclampsia).

          -  Laboratory and clinical sign of chorioamnionitis.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Does Tension-Free Herniorrhaphy or Laparoscopic Herniorrhaphy Achieve Equal or Better Recurrence Rates and Lower Costs While Achieving Equivalent Outcomes for Hernia Patients?

Eligibility criteria:
Inclusion Criteria:

        Men with inguinal hernia.

        Exclusion Criteria:
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Genotype and Susceptibility to COVID-19

Eligibility criteria:
Inclusion Criteria:

        - Age > 18 years

        Exclusion Criteria:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment