Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Genetic Component of Handedness

Eligibility criteria:
INCLUSION CRITERIA:

        Members of families meeting the following criteria are eligible to participate:

        Have two left-handed siblings.

        Have at least one right-handed parent with no other known left-handed first degree
        relatives.

        EXCLUSION CRITERIA:

        All members of a family may be excluded if the right-handed parents or the left-handed
        siblings will not participate.

        Individuals in families whose left-handed siblings are under the age of eight are not
        eligible to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study)

Eligibility criteria:
Inclusion Criteria:

          -  Ability of the participant or his legally authorized representative (e.g., parent or
             legal guardian) to understand the purpose and risks of the study and provide signed
             and dated informed consent and authorization to use protected health information in
             accordance with national and local participant privacy regulations

          -  Male participants of any age diagnosed with severe hemophilia A (as confirmed from the
             medical record)

          -  Currently diagnosed with high titer inhibitors (historical peak greater than or equal
             to (>=) 5 Bethesda units per milliliter (BU/mL), according to medical records)

          -  Previously treated with any plasma-derived or recombinant conventional or Extended
             Half-Life FVIII

        Exclusion Criteria:

          -  Other coagulation disorder(s) in addition to hemophilia A

          -  Previous immune tolerance induction (ITI)

          -  History of hypersensitivity or anaphylaxis associated with any factor VIII (FVIII)
             administration

          -  Planned major surgery scheduled during the study unless deferred until after study
             completion (minor surgery such as tooth extraction or insertion/replacement of central
             venous access device is allowed)

          -  Abnormal renal function (serum creatinine >1.5 milligram per deciliter (mg/dL) or 2 ×
             upper limit of normal (ULN) for participant age based on local laboratory range) as
             assessed by local laboratory

          -  Serum alanine aminotransferase or aspartate aminotransferase > 5 × upper limit of
             normal (ULN) as assessed by local laboratory
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

Eligibility criteria:
Inclusion Criteria:

          -  verified osteoarthritis (x-ray)of the knee, female,

        Exclusion Criteria:

          -  dementia, inflammatory diseases, regular pain medication
Female

Subject must be at least 55 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: MAgnetic Gastrointestinal Universal Septotome: a Safety and Feasibility Study (MAGUS)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or older.

          -  Patient has got evaluable symptoms (dysphagia, regurgitation, pain, weight loss,
             halitosis or others) associated with one of the following pathology:

               1. Diverticulum of the esophagus;

               2. A pseudo-diverticulum of the upper GI tract;

               3. Candy cane syndrome;

          -  Willing and able to comply with the study procedures and provide written informed
             consent to participate in the study.

        Exclusion Criteria:

          -  Refractory stenosis of the UGI proximal to the septum;

          -  Septum height smaller than 2,5 cm or higher than 6 cm (check through CT scan, Barium
             Swallow or other imaging method);

          -  Coagulation disorders;

          -  Previous implantation of a magnetic-sensitive medical device (including active
             electronic implant, metallic stent, …);

          -  Dysphagia related to motility disorder;

          -  Planned MRI in the following month (30 days) of intervention.

          -  Concurrent medical condition that would affect the investigator's ability to evaluate
             the patient's condition or could compromise patient safety;

          -  Patient went through a surgery less than 8 weeks before implantation of the magnets;

          -  Currently enrolled in another clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Definite, probable, or probable-laboratory supported ALS according to the revised El
             Escorial World Federation of Neurology criteria.

          -  Intake of riluzole 50 mg twice a day (bid)

          -  A disease duration at inclusion of more than 6 months and less than 36 months
             [inclusive] (disease onset is defined as the date of first symptoms excluding muscle
             cramps and fasciculations)

          -  Vital capacity (VC%) ≥ 70% of normal value (slow expiration, best of a minimum of
             three and a maximum of five measurements, with a respiratory function validly
             assessable and a spontaneous, non-assisted ventilation)

          -  Ages 18 - 85 years (inclusive)

          -  Capable of thoroughly understanding the trial information given; has signed the
             informed consent.

        Exclusion Criteria:

          -  Tracheostomy, tracheostomal ventilation of any type, non-invasive ventilation more
             than 16 hours/ day, or supplemental oxygen during the last three months prior to
             inclusion.

          -  Any medical condition or intoxication known to have an association with motor neuron
             dysfunction, which might confound or obscure the diagnosis of ALS.

          -  Presence of any concomitant life-threatening disease or any disease or impairment
             likely to interfere with functional assessment.

          -  Confirmed hepatic insufficiency or abnormal liver function (ASAT, ALAT greater than
             twice the upper limit of normal range).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Early Luteal Hormones and IVF Outcomes After hCG Triggering

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 - 38

          -  BMI < 28kg/m2

          -  Having 4 to 19 follicles with diameter of 12mm or above on the day of hCG triggering

          -  Receiving a standard GnRH-antagonist protocol for ovarian stimulation

          -  Having indication for fresh embryo transfer

          -  Willingness to participate in the study, and to disclose any medical conditions to the
             investigator. The patient must be prepared and willing to comply with the requirements
             of the protocol.

          -  The patient should after appropriate oral and written consent understand the study and
             be informed that she may withdraw consent at any time without prejudice to future
             medical care.

        Exclusion Criteria:

          -  Previous poor ovarian response (≤ 3 follicles) after appropriate FSH stimulation

          -  Hyper-response defined as >20 follicles ≥ 14 mm on the day of trigger

          -  Chronical medical conditions like Diabetes, Crohns disease, Thyroid disease, Hepatitis
             B, Sexually Transmitted Diseases and simultaneous participation in an interventional
             clinical trial.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 38 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Ovulation and Follicular Development Associated With Mid Follicular Phase Initiation of Combined Hormonal Contraception

Eligibility criteria:
Inclusion Criteria:

          -  healthy women, age 18 - 40 years

          -  prior normal and regular interval of menstruation

        Exclusion Criteria:

          -  current breast feeding women

          -  within 1 month period of child-delivery or miscarriage

          -  body mass index 30 kg/m2 or more

          -  contraindicated to use combined hormonal contraception

          -  current using other hormonal drugs that affect ovulation function
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: A Prospective Randomised Multi - Center Trial on the Repair of Large Hiatal Hernias: Absorbable Mesh vs. Pledgeted Sutures vs. Sutures Only

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a large hiatal hernia - admitted for surgery (laparoscopic /
             robot-assisted)

          -  Written informed consent

          -  ≥ 18 years of age

          -  Hiatal hernia documented by barium x-ray and/or gastroscopy and/or manometry by one or
             more of the following criteria:

               -  > 5cm hiatal hernia

               -  1/3 of the stomach in the thorax

        Exclusion Criteria:

          -  Lack of patient consent for study participation

          -  Lack of consent to study due to linguistic or mental incomprehension

          -  Patients in poor general condition (lack of anesthesia ability)

          -  Pregnancy

          -  Prior surgery on the stomach or gastroesophageal junction

          -  Simultaneous surgery because of another illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: The Efficacy of TGF for Treating Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          1. age between 50~75 years old

          2. diagnosis of osteoarthritis: The Clinical/Radiographic classification criteria of
             American College of Rheumatology, ACR

          3. chronic knee pain over 3 months.

        Exclusion Criteria:

          1. the past history with systemic joint disease, such as autoimmune disease

          2. the patient with history of knee surgery or waiting for the total knee replacement

          3. any disease that affect the function of lower extremities, such as trauma, tumor or
             compensation of abnormal posture

          4. the condition that cannot participate this study

          5. the subjects non-compliance with the protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: A Study to Confirm the Accuracy of Locally Advanced Gastric Cancer Diagnosis

Eligibility criteria:
Inclusion Criteria:

          -  Histological prove of adenocarcinoma of the stomach by endoscopy

          -  Preoperative imaging data by contrast-enhanced CT and clinical TNM stages were given

          -  No evidence of stage IV disease

          -  No previous gastrectomy or preoperative treatment.

        Exclusion Criteria:

          -  Discovery of distant metastasis (stage IV) during surgery

          -  Number of retrieved lymph node less than 15
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment