Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Essential Hypotension and Allostasis Registry

Eligibility criteria:
Inclusion Criteria:

          -  Any patient regardless of the age of gender

        Exclusion Criteria:

          -  Any non-correctable secondary cause of increase or decrease in blood pressure

          -  or a pathology that alters the prognosis before the entrance of the patient into this
             registry.

          -  nephropathy prior to the admission,

          -  familial dyslipidemia,

          -  previous gastric bypass,

          -  pre-existing heart failure,

          -  chemotherapy-induced cardiotoxicity,

          -  arrhythmogenic right ventricular dysplasia,

          -  long QT syndrome,

          -  hypertrophic cardiomyopathy

          -  restrictive cardiomyopathy or sudden death syndromes other than coronary disease

          -  Down syndrome,

          -  having one single kidney before entering to this registry,

          -  polycystic kidney,

          -  disability to continue with the treatment

          -  organ transplantation (other than cornea),

          -  HIV positive,

          -  homocystinuria,

          -  myelomeningocele,

          -  autoimmune diseases,

          -  paraplegia,

          -  chronic infections (TB),

          -  myocarditis of any cause,

          -  blood dyscrasia with coagulation disorders,

          -  history of pulmonary embolism,

          -  sustained or non-sustained ventricular tachycardia,

          -  idiopathic tachycardia associated with syncope which is not cured by radiofrequency
             ablation,

          -  pulmonary hypertension,

          -  diabetes insipidus,

          -  COPD,

          -  Gitelman syndrome,

          -  Cervical cancer associated with human Papillomavirus,

          -  multiple sclerosis,

          -  hemochromatosis,

          -  not compact ventricle.

        It is important to emphasize that all of these patients, currently excluded from the
        registry, may be studied in the future, they keep on follow-up and taken 6 BP.

        Additionally it is planned to compare the evolution of patients with secondary causes of
        hypertension or hypotension with essential disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction