Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: How Routine Biomarkers and Blood Leucocytes Count Can Assist Diagnosis of COVID-19 in Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  patient suspected of COVID19

        Exclusion Criteria:

          -  patient unsuspected of COVID19
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities

Eligibility criteria:
Inclusion Criteria:

          -  Mild to moderate IDD (IQ of 74-40).

          -  Sufficient functional ability to understand directions, communicate preferences,
             wants, and needs through spoken language.

          -  Living at home with a parent or guardian who is willing to participate in the
             intervention, with no plans to change this living situation and/or to leave the study
             area in the next 18 mos.

          -  Wireless internet access in the home.

        Exclusion Criteria:

          -  Unable to participate in moderate to vigorous physical activity (MVPA).

          -  Pregnancy during the previous 6 mos., currently lactating, or planned pregnancy in the
             following 18 mos.

          -  Unwilling to be randomized.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Pelvic Floor and Sexual Dysfunction in Women With Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  being between the ages of 18-65

          -  being a woman,

          -  having sex partner,

          -  no smoking, no alcohol

        Exclusion Criteria:

          -  physical, psychological, cognitive impairment,

          -  having a non-Sjögren additional disease,

          -  malignancy,

          -  pregnancy,

          -  no urogenital disease,

          -  sarcoidosis,

          -  AIDS,

          -  anticholinergic drug use,

          -  had a gynecological or urological operation other than cesarean
Female




Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Treatment of Lateral Epicondylitis: Platelet Rich Plasma Versus Steroid Versus Saline Solution

Eligibility criteria:
Inclusion Criteria:

          -  Duration of tennis elbow > 6 months

          -  Doppler activity on ultrasonography

          -  Lateral elbow pain that is maximal over the lateral epicondyle, and increases with
             pressure on the lateral epicondyle, and resisted dorsiflexion and/or middle finger.

        Exclusion Criteria:

          -  Inflammatory disease.

          -  Fibromyalgia.

          -  Pain in hand or shoulder/neck in the same arm as being treated.

          -  Anticoagulation treatment.

          -  Wounds around the elbow.

          -  Treatment with steroids within the last 3 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome

Eligibility criteria:
Inclusion criteria:

        Recruitment inclusion criteria for Systemic diseases participants:

        1. Clinically diagnosed with Primary Sjogren's Syndrome, Rheumatoid Arthritis or Systemic
        Lupus Erythematosus.

        Recruitment inclusion criteria for controls:

          1. NO Dry eye or severe Meibomian Gland Disease

          2. NO current or recent (< 6 months) conjunctivitis, keratitis, uveitis or other
             inflammatory condition affecting eye

          3. NO recent ocular surgery or LASIK (< 6 months)

          4. Frequency of dry eye symptoms is < once/week (burning, tearing, itching, foreign body
             sensation, transient blurring improved by blinking)

          5. NO contact lens wear for the past 1 week

          6. NO systemic conditions of Diabetes Mellitus, Rheumatoid Arthritis, Systemic Lupus
             Erythematosus

          7. Bulbar redness is < 1.5 grading

        Exclusion Criteria:

          1. Known history of thyroid disorders (diagnosed by physician)

          2. No ocular surgery within the last 3 months and LASIK within 1 year.

          3. Ocular surface diseases such as pterygium, or obvious lid/orbital disease with
             lagophthalmos.

          4. Any other specified reason as determined by clinical investigator.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism

Eligibility criteria:
Inclusion Criteria:

          -  Volunteers patients with hypogonadism

        Exclusion Criteria:

          -  Coronary heart disease

          -  Other pituitary/hypothalamic disorders or other non-hypogonadism diseases

          -  None was receiving vitamins, lipid-lowering drugs, or other medications known to
             interfere with PON1 activity, lipid profile, or gonadal function
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Dexamethasone Versus Placebo in Optimizing the Postoperative Period After Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  patients planned for elective laparoscopic hernia repair (TAPP)

          -  Unilateral inguinal or femoral hernia

          -  ASA class I-II

          -  Read and speak Danish

        Exclusion Criteria:

          -  Acute hernia operation

          -  Operation for other hernias with mesh during the same procedure

          -  Endocrine disease (diabetes, adrenal insufficiency etc.)

          -  fever/infection within the first 10 days before operation

          -  Poor compliance

          -  No signed consent form

          -  Daily intake of opioids or anxiolytic drugs

          -  Manic episodes

          -  Use medicine against glaucoma

          -  Use thiazide or loop diuretics

          -  Vaccination within the last 14 days
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: COVID-19 Infection in Cancer Pantients

Eligibility criteria:
Inclusion Criteria:

          -  confirmation of COVID-19 in the laboratory (RT-PCR techniques);

          -  suspected cases of COVID-19; clinically diagnosed based on symptoms (fever> 37.5 °,
             decrease in oximeter saturation by at least 5%, cough, diarrhea, otitis, dysgeusia,
             myalgia, arthralgia, conjunctivitis and rhinorrhea) + close contact a COVID-19 subject
             positive;

          -  asymptomatic cases; diagnosed based on positive swab results but without symptoms even
             dead patients

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Safety, Tolerability and Pharmacokinetics of SAR113945 Following Intra-articular Administration in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion criteria:

          -  Male patients or female patients of non child-bearing potential, aged at least 40
             years with primary knee osteoarthritis having:

               -  X-ray or Magnetic Resonance Imaging (MRI) evidence for Kellgren Lawrence Grades
                  II./III joint space narrowing and osteophyte formation,

               -  Western Ontario MacMaster (WOMAC) score ≦ 72,

               -  American College of Rheumatology (ACR) Clinical and Radiographic criteria for
                  osteoarthritis.

        Exclusion criteria:

          -  Any uncontrolled, chronic condition or laboratory finding which, in the opinion of the
             Principal Investigator, could potentially put the patient at increased risk.

          -  Secondary osteoarthritis.

          -  Moderate/severe renal impairment.

          -  Underlying hepatobiliary disease and/or elevated Alanine Aminotransferase (ALT) > 3
             Upper Limit of Normal range.

          -  Intra-articular injection within 3 months.

          -  Presence of local skin abnormality at the affected knee joint.

          -  Unable to be maintained for at least 2 weeks prior to entry into study on paracetamol
             or metamizole as analgesic.

          -  Any Investigational Product within 3 months.

          -  Any patient unlikely to comply with the requirements of the study.

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder

Eligibility criteria:
Inclusion Criteria:

          -  - Men or women, right handed, 18 to 80 years

          -  Patients with type 1 Narcolepsy according to the criteria of the International
             Classification of Sleep, 3rd version, 2014

          -  Acceptance of the protocol and signature of a written consent

          -  Social security affiliation

        Exclusion Criteria:

          -  Previous history of psychosis or psychiatric disease

          -  History of stroke or vascular lesion on MRI.

          -  Perceptual disorder (vision, hearing) may hinder the realization of the protocols,

          -  Dementia defined by a score across Montreal Cognitive Assessment (MoCA) <26/30.

          -  Major depressive state defined by a score scale Beck Depression Inventory (BDI)> 14

          -  Apathy defined by a score ≥ 14 on the Apathy Scale of Starkstein. Patients with a
             score ≥ this one will be excluded.

          -  Usual contraindications to MRI, knowing that no contrast agent injection is performed.

          -  Pregnant woman.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment