Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: The BD Odon DeviceTM for Assisted Vaginal Birth: a Feasibility Study to Investigate Safety and Efficacy

Eligibility criteria:
Inclusion Criteria:

          -  The woman is ≥18 years of age

          -  The woman has a singleton pregnancy

          -  The pregnancy is ≥28+0 weeks' gestation

          -  There is a negative antenatal screen for HIV and Hepatitis B

        Exclusion Criteria:

          -  The woman does not fulfil all of the inclusion criteria listed

          -  There is a diagnosis of a fetal skull abnormality precluding AVB (i.e. macrocephaly)

          -  There is a known osteogenesis imperfecta affected pregnancy

          -  There is suspicion of a fetal bleeding disorder (von Willebrand's disease, AITP,
             haemophilia)

          -  There is an intrauterine fetal death in the current pregnancy

          -  The woman is sensitive to latex

          -  The woman is currently serving a prison sentence

          -  The woman lacks capacity to consent

          -  The woman has a lack of ability to read or understand French as this would preclude
             successful completion of questionnaires

          -  The woman has received intramuscular or intravenous opiates (i.e. pethidine or
             morphine) within the past 6 hours

          -  The woman is in established labour (≥ 4cm cervical dilatation) without regional
             analgesia in place
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement

Eligibility criteria:
Age 18-45.

        Males.

        No current mood symptoms.

        No past psychiatric history.

        Not taking ongoing medications.

        No medical illnesses.
Male
Accepts Healthy Volunteers



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Endoscopic Treatment for Zenker's Diverticulum

Eligibility criteria:
Inclusion Criteria:

          -  patients with symptomatic ZD treated by endoscopic procedures

        Exclusion Criteria:

          -  pregnancy and breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Collection of Blood in Normal Subjects and Subjects With Von Willebrand Disease (VWD)

Eligibility criteria:
Inclusion Criteria:

          1. Normal subjects:

             - study individuals will be taken from those enrolled in Weill-IRB protocol
             #0005004439 entitled "Evaluation of the Lungs of Normal (Smokers, Ex-smokers,
             Non-smokers) Individuals with Segmental Bronchopulmonary Lung Lavage, Bronchial
             Brushing, and Bronchial Wall Biopsy"

          2. Subjects with von Willebrand Disease

               -  a definitive diagnosis on VWD from a patient's physician

               -  all subjects should be able to provide informed consent

               -  males or females 18-70 years of age

        Exclusion Criteria:

          1. Normal individuals

               -  individuals with a history of bleeding disorders

               -  individuals with anemia (defined as females with an Hgb concentration less than
                  12 and males with an HgB concentration less than 12.5)

          2. Subjects with VWD

               -  females who are pregnant will not be accepted into the study

               -  individuals with anemia (defined as females with an Hgb concentration less than
                  12 and males with an Hgb concentration less than 12.5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Variability of Whole Blood Clotting Time Measurements in Ex Vivo Human Blood Samples Spiked With Anticoagulants

Eligibility criteria:
Inclusion Criteria:

          1. Signed and dated informed consent form

          2. Healthy male and female subjects aged 18 to 65 years (inclusive) with suitable veins
             for venipuncture -

        Exclusion Criteria:

          1. Subjects who cannot communicate reliably with the Investigator

          2. History of major bleeding or major trauma within the 6 months prior to signing
             informed consent

          3. Propensity to bleeding (i.e. due to recent trauma, surgery, peptic ulcer,
             gastrointestinal bleeding or hemorrhoids)

          4. Significant infection or known inflammatory process in the 2 weeks prior to screening

          5. Active smoker or current use of any tobacco products or use within 3 months prior to
             signing informed consent

          6. Treatment with any investigation product or therapy within 30 days prior to screening

          7. Received non-steroidal antiinflammatory drugs or medications (including anticoagulants
             or aspirin) with a direct effect on hemostasis within 7 days of blood sampling

          8. Unwilling to comply with the procedures in the protocol

          9. Currently enrolled in any other study -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: REAL-LIFE DATA OF CONSTITUTIONAL VON WILLEBRAND DISEASE IN WESTERN FRANCE (HOPSCOTcH-WILL)

Eligibility criteria:
Inclusion Criteria:

          -  Constitutional VWD patient, of any severity, with or without inhibitors (according to
             the CRMW criteria*),

          -  Patient included in the research database BERHLINGO

          -  Patient treated or not by desmopressin or VWF/FVIII/by-passing agents available on the
             French market (at baseline)

          -  Patient who agrees to participate in the HOPSCOTcH and followed in one of the 5
             investigator HTC

          -  Patient who are not under guardianship

               -  CRMW criteria for constitutional VWD definition:

        Severe forms: VWF:Ag and VWF:RCo <5 UI/dL VWD 2A or 2M: VWF:RCo/VWF:Ag < 0.7 and/or ratio
        VWF:CB/VWF:Ag < 0.7 VWD 2B: unexplained thrombopenia and/or positive RIPA < 0.8 mg/mL (for
        any value of VWF:RCo/VWF:Ag) VWD 2N: FVIII:C/VWF:Ag < 0.6 and reduced to very reduced
        VWF:FVIIIB VWF:Ag <30 UI/dL (in the absence of every previous criteria)

        Exclusion Criteria:

          -  Patients Under guardianship
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients

Eligibility criteria:
Inclusion Criteria:

          1. Presence of symptomatic (BDI < 6), and moderate sized (> 1/3 of hemithorax) MPE

          2. Persistent malignant pleural effusion that is free flowing

          3. Life expectancy of at least 2 months (approximate duration of follow-up for the study)

          4. Age greater than 18

          5. Consent to undergoing TPC treatment for recurrent MPE

        Exclusion Criteria:

          1. Prior attempted chemical pleurodesis on ipsilateral side

          2. Active pleural or pulmonary infection

          3. Currently hospitalized for reasons other than MPE or in hospice care

          4. Life expectancy estimated at less than 2 months

          5. Inability to complete questionnaires (English or French)

          6. Refusal to give informed consent

          7. Pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Characteristics and Outcome of Coronavirus Disease 2019 (COVID-19) in Egypt

Eligibility criteria:
Inclusion Criteria:

          -  Patients with diagnosis of Covid-19 .

        Exclusion Criteria:

          -  Patients refuse to participate in the study
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Knee Brace and Biomechanical Footwear in the Treatment of Knee Osteoarthritis.

Eligibility criteria:
Inclusion Criteria:

          -  moderate or severe knee pain (>40mm on a VAS scale 0-100mm)

          -  radiographic knee osteoarthritis (Kellgren-Lawrence grades 1-3)

          -  age between 45 and 70 years

        Exclusion Criteria:

          -  inflammatory joint disease

          -  acute (<6 months) knee trauma

          -  arthroscopic surgery in the past six months

          -  a planned knee replacement surgery or other planned surgical treatment of the knee

          -  knee injections in the past 3 months

          -  superficial wounds at the knee area

          -  arterial insufficiency

          -  severe varicosities

          -  impaired vision

          -  postural difficulties

          -  body-mass index (BMI) >35kg/m2

          -  fibromyalgia

          -  rheumatoid arthritis or other active rheumatoid inflammatory disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Movement of Epiglottis During Swallowing

Eligibility criteria:
-  INCLUSION CRITERIA:

        Included subjects will be healthy adults age 18-65 years with normal swallowing function,
        as determined with a medical history and physical examination by an otolaryngologist.

        EXCLUSION CRITERIA:

        Exclusion criteria include the following circumstances:

          -  Subjects must not have a history of chronic swallowing difficulty or dysfunction.

          -  Pregnant volunteers will be excluded due to risks associated with radiation exposure.

          -  Women who are nursing will be excluded.

          -  Subjects must not currently be suffering from a psychiatric disorder other than
             depression, as evidenced by being under the care of a psychiatrist, or on medications
             for treatment of a psychiatric disorder.

          -  History of brain injury or neurological disease.

          -  History of epileptic seizure.

          -  History of Rheumatic fever, mitral valve prolapse, heart murmurs, or cardiac
             arrhythmias as determined by medical history, physical and EKG will disqualify a
             subject.

          -  Subjects must not be taking any medications, including herbal types that can affect
             coagulation.

          -  Subjects will be excluded if they have a history of allergies to lidocaine or any
             other anesthetic medication.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction