Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Quantitative Diaphragmatic Ultrasound Evaluation in Pleural Effusions : A Feasability Study

Eligibility criteria:
Inclusion Criteria:

          -  Age> 18 years old

          -  Male or female patient

          -  Patient with known lung cancer, regardless of histology or suspected of having unknown
             lung cancer or relapse / progression of lung cancer

          -  Presenting a pleural effusion with clinical necessity of evacuating pleural puncture

          -  Subject who expressed his non opposition to the research

        Exclusion Criteria:

          -  Patient's refusal to participate in the study

          -  History of pleurodesis whatever the indication (pneumothorax or recurrent pleural
             effusion) or the technique used

          -  Permanent chest drain

          -  inability to provide informed information to the subject (subject in an emergency,
             difficulty understanding the subject, etc.)

          -  Subject under judicial protection

          -  Subject under guardianship or curatorship

          -  Pregnant or lactating woman
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.

Eligibility criteria:
Inclusion Criteria:

          -  Patients ≥18 years old

          -  Large volume of pleural effusion (1 liter and more), required evacuation

          -  Systemic therapy with a checkpoint inhibitor (monotherapy or combination with another
             checkpoint inhibitor)

          -  Metastatic cancers (renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC)

        Exclusion Criteria:

          -  Autoimmune disorders

          -  Previous treatment for
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: MURDOCK Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study

Eligibility criteria:
Inclusion Criteria:

          -  MURDOCK Study participants ( Pro00011196) currently residing in North Carolina who
             have a valid email address on file.

        Exclusion Criteria:

          -  MURDOCK Study participants ( Pro00011196) currently not residing in North Carolina

          -  MURDOCK Study participants without a valid email address on file.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: STRETTA ,Radio Frequency Ablation (RFA) v/s Sham Therapy for the Treatment of Refractory GERD

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18years

          -  Small hiatus hernia (< 2-3 cm)

          -  Los Angeles Grade 'A' or 'B' Reflux Esophagitis

          -  LES pressure : 5 - 15 mm Hg

          -  PPI dependent / refractory GERD

          -  24 hr acid exposure study showing abnormal esophageal acid exposure > 4%

          -  DeMeester Score >14.7

          -  Esophageal manometry showing normal peristalsis

        Exclusion Criteria

          -  Age < 18 years

          -  Large hiatus hernia (> 3 cm)

          -  Los Angeles Grade 'C' or 'D' Reflux Esophagitis

          -  LES pressure : < 5 or > 15 mm Hg

          -  Underlying coagulation disorder

          -  Previous Esophageal or Gastric surgery

          -  H/o coronary artery disease (CAD)

          -  Esophageal manometry showing ineffective peristalsis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Menstrual Cycle Symptom Tracking

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Aged 18 years and over

          -  Regular menstrual cycles

          -  Owns a compatible smart phone i.e. iPhones® and AndroidTM phones equipped with
             Bluetooth® 4.0/BLE

          -  Willing to use their own smartphone for the duration of this study and to download and
             install the study app

          -  Willing to give informed consent

        Exclusion Criteria:

          -  Currently trying to conceive

          -  Currently or recently pregnant or breastfeeding

          -  Taking any treatment which may affect the menstrual cycle (e.g. contraceptive pill,
             fertility medications or hormone replacement therapy)

          -  Taking or undergoing any other medical treatment for fertility such as ovulation
             drugs, artificial insemination and assisted fertility such as In vitro fertilization
             (IVF) or Intracytoplasmic sperm injection (ICSI)

          -  Has abnormal liver or kidney function

          -  Taking antibiotics containing tetracycline

          -  Taking clomiphene citrate or other ovulation induction drugs
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  MCI Group: Diagnosis of mild cognitive impairment

          -  AD Family History Group: Confirmed family history of Alzheimer's and concurrent
             enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)

          -  Control Groups: Cognitively healthy and both parents survived past age 70 with no
             memory problems

        Exclusion Criteria:

          -  Claustrophobia

          -  Metallic or electronic implants or devices that are not MRI-safe
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia: A Pilot Study

Eligibility criteria:
Inclusion Criteria:

          1. Males or females with severe AD dementia (MMSE<12) between the ages of 70 to 90 years.

          2. Meet the criteria of AD (NIA-AA).

          3. If on any of the following medications: acetylcholinesterase inhibitors and/or
             memantine, participants must be on a stable dose for at least 60 days.

          4. Clinically stable for at least 3 months.

        Exclusion Criteria:

          1. Current or past history of malignancy.

          2. Previous history of radiotherapy.

          3. Neurological disorder other than AD.

          4. Currently receiving other experimental treatments.

          5. Clinical or imaging evidence of stroke (with more than 1-2 lacunar infarcts on CT scan
             or MRI).

          6. Major depression, bipolar affective disorder or psychosis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Laparoscopic Recurrent Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Recurrent inguinal hernia

        Exclusion Criteria:

          -  complicated inguinal hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 4 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: A Clinical Trial to Study the Safety and Efficacy of Chandrakanthi Choornam in Patients With Low Sperm Count

Eligibility criteria:
Inclusion criteria:

          -  Male infertile Patients with age between 21-45 yrs

          -  Marriage history for >1 year

          -  Abnormal Sperm count 1-15 million/ml

          -  Patients with normal Liver & Renal function test

          -  Willing to give specimen of semen before & at the end of the clinical trial

          -  Informed patients giving written consent

        Exclusion criteria:

          -  Azoospermia - complete absence of sperm cells in the ejaculate

          -  Aspermia - complete lack of semen

          -  Necrospermia- Spermatozoa in semen are either immobile or dead.

          -  Clinical diagnosis of Varicocele & Hydrocele

          -  History of Undescended testis

          -  Inguinal hernia on physical examination

          -  Male accessory gland infection

          -  History of DM, Hypertension and Cardiac disease

          -  Any recent medical or surgical illness

          -  Underwent treatment for promoting Spermatogenic fertility in last 3 months

          -  Other Systemic disease requiring specific therapies

          -  Known Thyroid disease

          -  Past history of Renal, Hepatic or any other chronic illness in the Patient
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction