Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Ultrasound Examination of Inguinal Lymph Node Used to Evaluate the Effect of Acupuncture on Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          1. Patients who meet the western medicine diagnostic criteria of knee osteoarthritis;

          2. Aged between 50 and 75 years;

          3. Patients in line with the 0-III level of radiological classification for knee
             osteoarthritis degeneration;

          4. Patients who did not use glucocorticoid via oral administration or intramuscular,
             articular, or soft tissue injection four weeks before accepting the test agent;

          5. Normal line of force;

          6. Patients who signed the informed consent and ensured the compliance.

        Exclusion Criteria:

          1. Patients with long-term oral administration of agents for knee osteoarthritis, and
             still in the drug effect period, without elution;

          2. Patients with severe heart, brain, liver, kidney or lung dysfunction;

          3. Patients with other knee diseases found in arthroscopic surgery;

          4. Patients who have accepted other relevant treatments, which may affect the observation
             on the effects of this study;

          5. Patients with mental illness;

          6. Patients with coagulation dysfunction;

          7. Patients with articular surgical treatment;

          8. Patients with a history of abuse of opioid analgesics, sedative hypnotics or alcohol;

          9. Patients with poor compliance, who were unable to meet the requirements for follow-up.

         10. Pregnant and lactating women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Eligibility criteria:
-  INCLUSION CRITERIA:

        Patients with potentially malignant or suspicious lesions, or with biopsy proven lung
        cancers or esophageal cancers, malignant pleural mesotheliomas, mediastinal or chest wall
        neoplasms, thymoma/thymic carcinomas, or thoracic metastases from cancers of non-thoracic
        origin.

        Patients must have an ECOG performance score of 0-2.

        Patients must be 2 years of age or older. Note: Patients >= 2 and < 18 years of age may
        participate in research sample collection if the tissue acquisition is performed during a
        clinically indicated surgical procedure, and the sampling of tissue, blood and urine does
        not add risk to the clinically indicated procedures.

        Patients must be aware of the nature of his/her illness. The patient must be willing to
        undergo standard intervention that may include endoscopic biopsies of tumor and adjacent
        normal tissues, and to provide blood and urine samples to support ongoing laboratory
        research endeavors pertaining to the epigenetics of thoracic malignancies.

        Ability of subject, their parents/guardians or legally authorized representative (LAR) to
        understand and the willingness to sign a written informed consent document.

        EXCLUSION CRITERIA:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population

Eligibility criteria:
Inclusion Criteria:

          1. Asbestosis (defined as diffuse lung scarring based on increased profusion of
             interstitial fibrosis)

          2. Benign pleural disease (defined as thickening or fibrotic plaques on pleural surfaces
             of the lung bilaterally)

        Exclusion Criteria:

          1. Prior systemic chemotherapy, radiation therapy or both.

          2. A current or previous history of primary malignancy.

          3. Known allergy to artichoke.

          4. Known bile duct obstruction.

          5. Known pregnancy or lactating women.

          6. Known psychiatric illness/social situations that would limit study compliance.

          7. Receiving any other investigational agents.

          8. Inability to understand or unable to provide written informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Epidemiological Investigation of COVID-19 in Laos Using a One-Health Approach in Human and Animals

Eligibility criteria:
All permanent residents of the household who meet the inclusion criteria of > 6 months old
        and living in their respective village for at least 6 months will be eligible to
        participate. All people from the anterior LACORIS study (2015-2019), will be invited to
        participate to the study.

        Over a year, active case finding for influenza-like illness (ILI) will be conducted among
        the cohort by staff at CILM. The suspected ILI cases will be first identified using the WHO
        clinical case definition of ILI and Covid 19 as either with:

        Acute onset of fever (> 37.5˚C axillary temperature or > 38˚C tympanic temperature) AND
        cough; OR Acute onset of ANY ONE OR MORE of the following signs or symptoms: Fever, cough,
        general weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnoea, anosmia (loss
        of smell) or ageusia (loss of taste).

        with symptoms with onset within the last 10 days.

        Inclusion Criteria:

          -  Living in their respective village for 6 months or more.

          -  Physically reside in the village for more than 80% of the time during the duration of
             the study.

          -  Study subjects ≥ 6 months of age (no upper age limit).

          -  Consent form signed by patient, or if under 18 years of age or patients with learning
             difficulty or other vulnerability with impaired ability to decide on consent, signed
             by parent or guardian.

          -  Agrees to comply with study requirements.

        Exclusion Criteria:

          -  Study subjects under the age of 6 months.

          -  Study subjects or parents/guardians that do not accept participation.

          -  Study subjects or parents/guardians who refuse to sign informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: The KOMOtini BONE Study: Evaluation of the Osteogenic Potential of Sports

Eligibility criteria:
Inclusion criteria

          -  were 8-12 years and pre-pubertal

          -  were healthy and had no prior bone fractures or related surgical operation

          -  had not been involved in organized sport activities previously

          -  their body fat was <30%, e) had no history of growth irregularities

          -  were not receiving agents or drugs that affect bone tissue (e.g.
             Gonadotropin-Releasing Hormone (GnRH) agonists, antiresorptive, bisphosphonates, etc.)

        Exclusion Criteria:

          -  had prior bone fractures or related surgical operation

          -  had been involved in organized sport activities previously

          -  their body fat was >30%

          -  had history of growth irregularities

          -  were receiving agents or drugs that affect bone tissue (e.g. GnRH agonists,
             antiresorptive, bisphosphonates, etc.)

          -  missed more than 10% of training sessions
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Spleen-Preserving No. 10 Lymph Node Dissection in Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          1. Age from 18 to 80 years

          2. Primary distal gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell,
             or poorly differentiated) confirmed pathologically by endoscopic biopsy

          3. cT2-4a, N0-3, M0 at preoperative evaluation according to the American Joint Committee
             on Cancer (AJCC) Cancer Staging Manual Seventh Edition

          4. No distant metastasis is observed. And the spleen, pancreas or other adjacent organs
             are not involved by the tumor.

          5. Performance status of 0 or 1 on Eastern Cooperative Oncology Group scale (ECOG)

          6. American Society of Anesthesiology score (ASA) class I, II, or III

          7. Written informed consent

        Exclusion Criteria:

          1. Women during pregnancy or breast-feeding

          2. Severe mental disorder

          3. History of previous upper abdominal surgery (except laparoscopic cholecystectomy)

          4. History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal
             dissection

          5. Enlarged or bulky regional lymph node diameter over 3cm by preoperative imaging

          6. History of other malignant disease within past five years

          7. History of previous neoadjuvant chemotherapy or radiotherapy

          8. History of unstable angina or myocardial infarction within past six months

          9. History of cerebrovascular accident within past six months

         10. History of continuous systematic administration of corticosteroids within one month

         11. Requirement of simultaneous surgery for other disease

         12. Emergency surgery due to complication (bleeding, obstruction or perforation) caused by
             gastric cancer

         13. FEV1<50% of predicted values
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Comparison Between Rebamipide 2% Versus Autologous Serum

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of Sjögren's syndrome

          -  dry eye symtoms

        Exclusion Criteria:

          -  history of ocular surface surgery less than one year or intraocular surgery less than
             three months in one or both eyes

          -  chronic use of drops in one of both eyes (e.g. : treatment for glaucoma)

          -  anterior segment disease (ocular scar pemphigoid, Stenvens Jhonson syndrome)

          -  presence of punctung plug (lacrimal plug) inserted in one or both lower lacrimal
             points

          -  systemic viral infections (Hepatitis B, Hepatitis C, HIV)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Study of FYU-981 in Hyperuricemic Outpatients With or Without Gout (Effect on Two Hyperuricemic Types)

Eligibility criteria:
Inclusion Criteria:

          -  Serum urate level:

               -  >= 7.0mg/dL in patients with gouty nodule or with history of gout, or >=8.0mg/dL
                  in patients with hypertension, diabetes or metabolic syndrome, or >= 9.0mg/dL

          -  Disease type in the classification of hyperuricemia: Uric acid-overproduction type or
             Uric acid-underexcretion type

          -  Outpatients

        Exclusion Criteria:

          -  Gouty arthritis within 14 days before randomized allocation
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Contradiction