Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Patients With Hidradenitis vs Patients With Psoriasis: Psychological Impact

Eligibility criteria:
Inclusion Criteria:

          -  Men and women at least 18 years old at the time of selection.

          -  Subjects diagnosed with psoriasis or hidradenitis suppurativa

          -  Subjects who had completed the questionnaires for psychological impact.

          -  Patients should be able to understand and communicate with the investigator.

        Exclusion Criteria:

          -  Subjects suffering from a serious concomitant illness.

          -  Subjects with a mental illness.

          -  Subjects who are performing psychiatric treatment.

          -  Patients who have alcohol dependence or drug abuse.

          -  Subjects that present legal incapacity or limited legal capacity.

          -  Subjects presenting illiteracy or language barriers.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Dietary Advice on Prescription in Kungsbacka

Eligibility criteria:
Inclusion Criteria:

          -  BMI 28-35

        Exclusion Criteria:

          -  Severe disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of Inhaled TPI 1100 in Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, male or female volunteers aged 18 to 55 years inclusive

          -  Screening/baseline FEV1 greater than 90% predicted,

          -  Body mass index (BMI) of 19 to 28 inclusive,

          -  Clinical laboratory values and/or vital signs within normal reference ranges or not
             considered clinically significant by the Investigator

        Exclusion Criteria:

          -  Airways or systemic conditions that might affect respiratory function, including but
             not limited to clinically significant cardiac problems,

          -  Breast-feeding or pregnancy,

          -  Positive tests for smoking tobacco, alcohol, hepatitis B-surface antigen, hepatitis C
             antibody, and HIV at screening,

          -  History of serious adverse reaction to any drugs,
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Synovial Fluid Bank From Arthritic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Significant joint effusion

        Exclusion Criteria:

          -  Hemorrhagic effusion

          -  Traumatic effusion

          -  Less than 3 ml total of collected fluid (used for routine analysis and culture)

          -  Inability or refusal to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Intervention Study to Improve Life and Care for People With Dementia and Their Caregivers in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  70+ years

          -  must be living at home

          -  screening positive (DEMTECT < 9), indicating dementia

        Exclusion Criteria:

          -  medical conditions not allowing testing
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.
Subject must be at most 120 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Efficacy of L. Plantarum and P. Acidilactici in Adults With SARS-CoV-2 and COVID-19

Eligibility criteria:
Inclusion Criteria:

          -  Women or men, >18y to 60 years

          -  RTq-PCR to COVID positive

          -  Presence of cough, fever, dyspnoea, or headache, onset <= 7 days

          -  Mild severity of COVID-19

          -  Peripheral Oxygen Saturation (SpO2) >90%

          -  Able to read, understand and sign the informed consent

          -  To have at least one family member to collaborate with the follow-up in the clinical
             findings at beginning and throughout of the study.

        Exclusion Criteria:

          -  Severe Obesity (BMI>40)

          -  Uncontrolled Type II diabetes (HbA1C >8.0)

          -  Uncontrolled systolic hypertension (>160mmdeHg)

          -  Acute pancreatitis

          -  Chronic diarrhea or constipation

          -  Inflammatory bowel disease

          -  Blood clotting disease

          -  Immunosuppression derived from Cancer, post-transplantation, auto-immune disease or
             HIV

          -  Severe and active seasonal allergies

          -  Pregnancy or lactation

          -  Glucose 6P-dehydrogenase deficiency

          -  Regular use of probiotic or antibiotic within 2 weeks before entering the trial

          -  Severe or uncontrolled Chronic Respiratory Diseases (Asthma, COPD or Cystic Fibrosis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Evaluating an Emergency Department Observation Syncope Protocol for Older Adults

Eligibility criteria:
Inclusion Criteria:

          -  Age≥60 years

          -  A complaint of syncope or near-syncope (Syncope is defined as a sudden, transient loss
             of consciousness. Near-syncope is defined as a sensation of imminent loss of
             consciousness, without actual syncope.)

          -  Intermediate risk of adverse outcome (see Table)

          -  Patient speaks either English or Spanish as a primary language.

        Exclusion Criteria:

          -  Syncope mimics (intoxication, weakness or dizziness with syncope/ near-syncope,
             hypoglycemia, and cardiac arrest)

          -  New or baseline cognitive impairment or dementia)

          -  Inability to provide follow-up information (e.g. homeless or resides outside of U.S.)

          -  Inability to speak Spanish or English

          -  Low- and high-risk patients (see Table).

        Risk Stratification Guidelines:

          -  High Risk

          -  Serious condition identified in ED

          -  History of ventricular arrhythmia

          -  Cardiac Device with dysfunction

          -  Presentation consistent with acute coronary ischemia

        Intermediate Risk

          -  No High Risk features

          -  Presentation not consistent with orthostatic or vasovagal syncope

        Low Risk

          -  Presentation consistent with orthostatic or vasovagal syncope
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Oxidative Stress and Lipidomics in Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  clinically healthy subjects and clinical healthy subjects with infertility

        Exclusion Criteria:

          -  subjects with endocrine, cardiovascular, metabolic, inflammatory and neurologic
             diseases or cancer

          -  subjects taking medicines and/or supplements
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Thrombin Generation Numerical Models Validation in Haemophilic Case

Eligibility criteria:
Inclusion Criteria:

          -  Signed consent form

          -  Age between 18 and 45 years old

          -  Male

          -  no smoker

        Exclusion Criteria:

          -  other clinical research protocol participation during the 3 months before inclusion

          -  Personal or familial history of hemorrhagic disease (parents, brothers and sisters

          -  Personal history of thrombosis (arterial or venous)

          -  Familial history of thrombosis before 45 years old (parents, brothers and sisters)

          -  Drug treatments of aspirin or anti-inflammatory type during the week before sampling

          -  Surgery the month before sampling

          -  Chronic pathology responsible for inflammatory syndrome

          -  Infectious episode in course
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Functional Gastrointestinal Disorder Screening Program - A Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

        Present with symptoms suggestive of any of the following FGID according to Rome III
        Classification:

          -  Non-erosive gastroesophageal reflux disease (NERD) Weekly symptoms of heartburn or
             acid regurgitation of moderate severity for at least 6 months

          -  Functional dyspepsia (FD) Weekly symptoms of epigastric burning sensation, early
             satiety or postprandial fullness for at least 6 months

          -  Irritable bowel syndrome (IBS)

        Symptoms of abdominal pain or discomfort of at least 3 times a month, in the last 6 months,
        associated with 2 or more of the following:

          -  Improvement with defecation

          -  Onset associated with a change in frequency of stool

          -  Onset associated with a change in form (appearance) of stool

        Exclusion Criteria:

          -  Erosive esophagitis (Still eligible for IBS patients)

          -  Peptic ulcer (Still eligible for IBS patients after complete ulcer healing)

          -  H. pylori positive

          -  Organic causes of symptoms, including malignancy, abnormal thyroid function, and
             inflammatory bowel disease.

          -  Previous gastric surgery

          -  Pregnancy

          -  Illiterate

          -  Unable to sign the written consent form • Abdominal surgery within one year prior to
             joining the program
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Verification of Computerized Sleep-wake Analysis in Sleep Disorders

Eligibility criteria:
Inclusion Criteria:

          -  age 20-50

          -  diagnosed as primary insomnia, periodic limb movement in sleep, simple snores, and
             obstructive sleep apnea

        Exclusion Criteria:

          -  arrhythmia

          -  sleep efficiency<50%

          -  combined other sleep disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction