Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  Provision of signed informed consent form

          -  BMI 18.5-35.0, inclusive

          -  Continuous PPI treatment for GERD during the last 4 weeks

        Exclusion Criteria:

          -  Patients that have not experienced any GERD symptoms improvement at all after PPI
             treatment

          -  Unstable or clinically significant disorders including cardiovascular, respiratory,
             renal, hepatic, metabolic, psychiatric, other gastrointestinal and esophageal
             disorders besides GERD

          -  Prior surgery of the upper GI tract
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: CARE Canadian ALS Riluzole Evaluation

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of ALS confirmed by the following definition:

             (a)"Probable" or "Definite" Amyotrophic Lateral Sclerosis (ALS) according to the El
             Escorial criteria(b)"Peripheral" onset form (limb involvement) or a "Bulbar" form of
             ALS with a duration of five years, based on inquiry for the earliest symptoms of the
             disease

          -  A subject who simultaneously presents with bulbar and peripheral signs at onset of ALS
             disease should be stratified to the bulbar onset group. The neurologic progression of
             such subjects matches that of the bulbar onset ALS subjects.

          -  Pulmonary Function: forced vital capacity (FVC) must be 3 60% at study entry.

          -  Females of childbearing potential must be documented to be using acceptable birth
             control methods such as an IUD or oral contraceptives.

        Exclusion Criteria:

          -  Previous treatment with riluzole

          -  Tracheostomy, or expected to undergo a tracheostomy within two months after study
             inclusion

          -  Signs of clinical dementia and/or major psychiatric disorders

          -  Serious concomitant disease or handicap likely to interfere with the subject's
             assessments or impact on the subject's survival

          -  A multiple conduction block has been shown on nerve conduction studies by
             electromyogram

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Predictability of the Ability to Perform an Emergency Stop After Surgery for Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  scheduled surgery for inguinal hernia of the right groin with Lichtenstein procedure

          -  valid driving license

          -  male and female

        Exclusion Criteria:

          -  lacking driving license

          -  pregnancy

          -  neuromuscular disorder (e.g. myopathy, muscular dystrophy)

          -  central neurological disorders/diseases (e.g. apoplexia, psychiatric diseases)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Performance During Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Women

          -  18-35 years of age

          -  BMI 18.5-25.

        Exclusion Criteria:

          -  Smoking

          -  hormonal or metabolic disorders

          -  chronic sickness

          -  use of medication

          -  breast feeding, vegetarians

          -  diet containing a lot of soja based products

          -  injuries which make it impossible to do the tests
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients

Eligibility criteria:
Inclusion Criteria:

          -  Men and women aged between 18 and 75 years.

          -  Signed and dated written informed consent.

          -  History of dry eye syndrome for at least 3 months

          -  Tear Break Up Time (BUT) ≤ 10 seconds or Schirmer I test ≤ 10 mm and ≥ 2mm

          -  Normal ophthalmic findings except dry eye syndrome, ametropia < 6 Dpt.

          -  Recommended use of topical lubricants, but no administration of topical lubricants 4
             weeks preceding the first study day.

        Exclusion Criteria:

          -  History or presence of ocular disease judged by the investigator as incompatible with
             the study.

          -  Any other topical ocular treatment than the study medication in the 4 weeks preceding
             the first study day and during the treatment period.

          -  Wearing of contact lenses.

          -  Symptoms of a clinically relevant illness in the 3 weeks before the first study day.

          -  Participation in a clinical trial in the 3 weeks preceding the first study day.

          -  Pregnancy, lactation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: "Can A Prescribed Walking Program With or Without Monitoring Impact Dizziness in the Older Adults?"

Eligibility criteria:
Inclusion Criteria:

          1. Age 65 years or older referred for physical therapy evaluation for symptoms of
             dizziness, postural instability, or both

          2. Able to walk without the physical help of another person, with or with no assistive
             device

          3. Able to follow commands and execute the examination and intervention instructions in
             the English language

          4. Willing to participate in a phone interview four weeks after discharge

          5. Able to provide informed consent

        Exclusion Criteria:

          1. Unstable medical issues, such as unstable or uncontrolled cardiovascular conditions,
             elevated blood pressure (Systolic greater than or equal to 140mmHg and diastolic
             greater than or equal to 90mmHg), orthostatic hypotension (a fall in systolic blood
             pressure of at least 20mmHg or diastolic blood pressure of at least 10mmHg when a
             person stands from a sitting or lying down position), uncontrolled metabolic disease,
             as determined by the evaluating physical therapist, documented in the Functional
             Comorbidity Index, vital signs and assessment portion of the initial evaluation.

          2. History of falls from syncopal origin

          3. Dizziness of central origin, such as stroke, head injuries, MS or PD;

          4. Active BPPV (patients with positive dix hallpike and/or roll test)

          5. Inability to walk without physical assistance.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Treatment of Heavy and/or Prolonged Menstrual Bleeding Without Organic Cause

Eligibility criteria:
Inclusion Criteria:

        Regular menstrual cycles with BMI (19-29 kg/m2). Heavy and/or prolonged menstrual bleeding
        involving at least last three consecutive menstrual cycles.

        Exclusion Criteria:

          1. Postmenopausal bleeding (over one year since the last menstrual period).

          2. Irregular menses or intermenstrual bleeding.

          3. Organic causes of heavy menstrual bleeding suspected or confirmed by experienced
             abdominal and transvaginal ultrasound after thorough general and gynecological
             examination.

          4. Iatrogenic (treatment-related) causes of heavy menstrual bleeding (e.g.
             non-progestogen-releasing intrauterine contraceptive device, oral contraceptives,
             other hormonal drug use or anticoagulant agent).

          5. Iron deficiency anemia.

          6. History of chronic diseases known to interfere with menstrual bleeding or prevent the
             use of any of the listed drugs e.g previous or current thromboembolic disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Manual Therapy Versus Exercise on Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of knee osteoarthritis.

        Exclusion Criteria:

          -  Inability to ambulate at least 100 feet, ride a stationary bicycle for at least 10
             minutes, or lie in the prone position for at least 10 minutes,

          -  Intra-articular knee injection within one month of study inception,

          -  A history of exercise induced or uncontrolled angina within three months of the study
             entry,

          -  Severe dyspnea at rest,

          -  Previous bilateral total knee arthroplasty,

          -  Pregnancy, OR

          -  The absence of knee pain at the time of recruitment for the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Microarray Analysis in Syndromic Obesity

Eligibility criteria:
Inclusion Criteria:

          -  children (under 18 year-old)

          -  obesity (following IOTF definition)

          -  at least one criteria among :

               -  mental retardation

               -  facial dysmorphism

               -  at least one major malformation (uro-genital, cardiac, skeletal, cerebral,
                  ophthalmologic…)

        Exclusion Criteria:

          -  common obesity

          -  obesity with an identified aetiology
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Web Accessible Population Pharmacokinetics Service - Hemophilia: Sources of Variability

Eligibility criteria:
Inclusion Criteria:

          -  individuals with hemophilia A or B

          -  infusion/PK data is available on the WAPPS-Hemo database

          -  given informed consent to data input on the WAPPS-Hemo database

        Exclusion Criteria:

        - individuals currently undergoing immune tolerance induction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment