Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

          -  Between the ages of 18 and 85

          -  Diagnosis of sarcoidosis confirmed by either biopsy or by manifestations consistent
             with acute sarcoidosis in absence of other known diagnosis.

          -  Have a suspected diagnosis of sarcoidosis and is scheduled to undergo a biopsy
             procedure to confirm a diagnosis of sarcoidosis.

          -  Able to tolerate and willing to undergo study procedures

        Exclusion Criteria:

          -  Current cigarette smoking or smoking within six months prior to the study

          -  Currently or recently (<6months) on immunosuppressive therapy

          -  Pregnancy

          -  Patient inability to participate in the study, such as undergo venipuncture and or BAL
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Vaginal Sildenafil Citrate on Endometrial Preparation and Outcome in Frozen Thawed Embryo Transfer Cycles

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing their first frozen embryo transfer cycle.

          -  have at least two high quality frozen embryos

        Exclusion Criteria:

          -  1. a history of endocrine diseases. 2. a history of hysteroscopic surgeries. 3.
             cardiovascular, renal and liver diseases. 4. hypotension (blood pressure <90/50 mmHg).
             5. a history of stroke or myocardial infarction.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Clinical Study of Wrist Blood Pressure Monitor in Conformance With the ANSI/AAMI SP10 Standard

Eligibility criteria:
Inclusion Criteria:

          -  male,female,

        Exclusion Criteria:

          -  below 18 years old
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Genes Influencing Iron Overload State

Eligibility criteria:
Inclusion Criteria:

          -  History of ≥ 12 lifetime erythrocyte transfusions who have not yet initiated treatment
             to unload iron (iron chelation or therapeutic phlebotomy), or

          -  History of ≥ 12 lifetime erythrocyte transfusions who have initiated treatment to
             unload iron, but had liver iron content measurement (by R2*MRI) within 3 months prior
             to initiation of iron unloading treatment

        Exclusion Criteria

          -  Known contraindication to performance of MRI (e.g.: presence of MRI-incompatible
             ferromagnetic material in the body)

          -  Prior participation on the St. Jude MRIRON protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study of Recombinant Factor VIIa Fusion Protein (rVIIa-FP, CSL689) for On-demand Treatment of Bleeding Episodes in Patients With Hemophilia A or B With Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects with hemophilia A or B and inhibitors.

          -  Age ≥ 12 and ≤ 65 years.

          -  High responding inhibitor with documented historical inhibitor titer > 5 Bethesda
             Units/mL.

        Exclusion Criteria:

          -  Congenital or acquired coagulation disorders other than hemophilia A or B.

          -  Ongoing immune tolerance induction therapy or planned during study.

          -  Known or suspected hypersensitivity to activated recombinant human FVII or to any
             excipient of CSL689.

          -  Body mass index > 30 kg/m².

          -  Major surgery within 28 days before screening or scheduled major and / or orthopedic
             surgery during the study.

          -  Advanced atherosclerotic disease (ie, known history of ischemic heart disease, or
             ischemic stroke).

          -  Any clinical signs or known history of thromboembolic events, including known deep
             vein thrombosis.

          -  Human immunodeficiency virus (HIV)-positive subjects who have low cluster of
             differentiation 4 (CD4)+ lymphocyte count (200/μL or less) at screening.

          -  Use of the following within the screening period or planned during study: a) plasma or
             coagulation factor concentrates other than rescue therapy or therapy during Part 1, b)
             other platelet inhibitors, c) desmopressin, and d) fibrinolysis inhibitors, except if
             used as local treatment (eg, for oral bleeds).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Chronic Sucrose Intake, Markers of Health and Biomarker Identification

Eligibility criteria:
Inclusion Criteria:

          -  Age 19-64, healthy diagnosis

        Exclusion Criteria:

          -  gastrointestinal issues, doesn't consume sugar
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 64 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Endometrial Injury for Assisted Reproduction

Eligibility criteria:
Inclusion Criteria:

          -  Women who will start assisted reproductive techniques with planned fresh embryo
             transfer.

          -  Age between 18 and 38 years.

          -  Written informed consent.

        Exclusion Criteria:

          -  None
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 38 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Impact of Immediate Point-of-Care Ultrasound on Patients With Cardiopulmonary Symptoms in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  Chief complaint of chest pain, dyspnea (either sudden onset or increased severity of
             chronic dyspnea), syncope, or hypotension (systolic blood pressure <100 or shock index
             [heart rate divided by systolic blood pressure] >1)

        Exclusion Criteria:

          -  <18 years old

          -  Prisoner or ward of the state

          -  Trauma

          -  High acuity requiring treatment in resuscitation room

          -  Obvious cause of symptoms (e.g. acute GI bleed causing hypotension)

          -  Any form of "do not resuscitate" (DNR) order

          -  Roomed in hall of emergency department (location not amenable to ultrasound protocol)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Endometrial Injury and Implantation Rates Before First ICSI Cycle

Eligibility criteria:
Inclusion Criteria:

          1. subfertile women indicated for ICSI.

          2. normal uterine cavity demonstrated by transvaginal ultrasound and hystrogram.

          3. FSH<10mIU/mL on day 3 of her cycle.

        Exclusion Criteria:

          1. presence of endometrial polyp or fibroid distorting the uterine cavity.

          2. hydrosalpinx.

          3. ICSI carried out for preimplantation genetic diagnosis.

          4. FSH>10mIU\mL.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effects of Lagenbone on Bone Mineral Density

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of osteoporosis

          -  Able to read and understand English

          -  Willing to receive routine DEXA scans and comply with supplement schedule

        Exclusion Criteria:

          -  Pregnant, lactating, or having gestational diabetes

          -  Diagnosed with comorbid conditions that they are taking medication for e.g. Acid
             reflux, Hashimoto's/Grave's Disease, Endometriosis, prostate, breast, uterine cancer,
             kidney disease, fibroids, psychological disorders

          -  Use of any medication known to interfere with bone mineral density

          -  Are taking any new medications/supplements/treatments/therapeutic exercise within the
             last two months for osteoporosis or bone density

          -  Involved in health-related litigation, claims

          -  Missing baseline visits

          -  Vegan or vegetarian

          -  Diagnosed with Alzheimer's or demonstrating onset of dementia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Effect of Creatine Supplementation and Exercise on Bone Health

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women

          -  Low or moderate risk of fracture

        Exclusion Criteria:

          -  High risk of fracture

          -  Have taken any bone-altering drugs within the previous 12 months

          -  Have taken creatine monohydrate in the previous 12 months

          -  Currently taking systemic corticosteroids

          -  Have Crohn's Disease or Cushings Disease

          -  Have severe osteoarthritis
Female
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment