Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Turner Syndrome: Genotype and Phenotype

Eligibility criteria:
-  INCLUSION CRITERIA - for TS Subjects:

        Phenotypic females greater than or equal to 10 years of age

        Evidence of X-chromosomal abnormality

        Those with a karyotype of 45X/46XX must have at least 80% 45X lymphocytes.

        EXCLUSION CRITERIA - for TS Subjects:

        Co-existing autosomal defects

        Pregnancy

        INCLUSION CRITERIA - for the Parents of TS Subjects (for DNA only):

        Biological parent of a TS subject

        Willingness to participate

        EXCLUSION CRITERIA - for the Parents of TS Subjects (for DNA only):

        None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Genes-in-Action - Hepcidin Regulation of Iron Supplementation

Eligibility criteria:
Inclusion Criteria:

          -  Be healthy and over 18 years of age old.

          -  Have provided appropriate ethical consent for involvement in studies relating to
             genetics.

          -  Have available genotype data based on previous or ongoing genetic studies. Fasted
             (overnight)

        Exclusion Criteria:

          -  Indication of infection/inflammation at the time of enrollment as determined by
             self-reporting, medical history or hematology (full blood count)

          -  Severe anemia (HGB<7 g/dL)

          -  Pregnant and lactating women

          -  Carrier of known genetic variants associated with iron metabolism (sickle trait, G6PD
             deficiency variants, HFE polymorphisms
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Documented history of dry eyes for at least 3 months.

          -  Ocular discomfort due to dry eyes.

          -  Presence of corneal and conjunctival staining.

          -  Other protocol-defined inclusion criteria may apply.

        Exclusion Criteria:

          -  Women who are pregnant or lactating.

          -  Contact lens wear within 1 week before Screening and during the study.

          -  Ocular surgery (of any type, including laser surgery) or ocular trauma within the 4
             months prior to Screening.

          -  Punctal plugs or punctal occlusion initiated within 3 months of screening

          -  Other protocol-defined exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Effects of Cranberry Extractive on the Lipid Profiles in Subjects With Type 2 Diabetes

Eligibility criteria:
Inclusion Criteria:

          -  type 2 diabetic subjects

          -  age between 50 and 75 years

        Exclusion Criteria:

          -  glycosylated hemoglobin (HbA1c) less than 7% or more than 10%;

          -  triglyceride more than 4.5 mmol/L;

          -  current insulin treatment;

          -  change of the medications for anti-diabetes, hypertension, hyperlipidemia and
             anti-platelet in recent four weeks;

          -  abnormal renal function (serum creatinine > 177 μmol/L;

          -  abnormal liver function test results (more than two-fold upper limit of normal range);

          -  severe systemic disease such as immune disorder, cancer, acute or chronic inflammation
             disease;

          -  smoking in recent 1 year;

          -  alcoholism (more than two drinks daily);

          -  using steroid or drugs with unknown components;

          -  pregnancy or breast-feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: The Role of Physical Activity for Acute Exacerbations of COPD

Eligibility criteria:
Inclusion Criteria:

          -  COPD GOLD stage B or higher

          -  Written informed consent

        Exclusion Criteria:

          -  Inability to provide written informed consent

          -  Insufficient knowledge of the trial language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Study of Diclofenac Capsules to Treat Osteoarthritis Pain

Eligibility criteria:
Inclusion Criteria:

          -  Primary diagnosis of Functional Class I-III OA of the hip or knee with documented
             osteoarthritis flare at baseline

          -  Chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or acetaminophen for
             OA pain

          -  Discontinued all analgesic therapy at Screening

          -  For women of child-bearing potential: a woman who is not pregnant and not nursing, and
             who is practicing an acceptable method of birth control

        Exclusion Criteria:

          -  History of allergic reaction or clinically significant intolerance to acetaminophen,
             aspirin, or any NSAIDS, including diclofenac

          -  Requires continuous use of opioid or opioid combination products to control OA pain of
             the knee or hip

          -  Clinically significant unstable cardiac, respiratory, neurological, immunological,
             hematological, or renal disease

          -  Significant difficulties swallowing capsules or unable to tolerate oral medication

          -  Previous participation in another clinical study of Diclofenac Capsules or received
             any investigational drug or device or investigational therapy within 30 days before
             Screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection

Eligibility criteria:
Inclusion Criteria:

          1. men and woman age 18 and older;

          2. Not hospitalized;

          3. Has recently tested SARS-CoV-2 (COVID-19 virus) positive.

          4. Currently symptomatic with one or more of one or more of the following symptoms:
             fever, cough, myalgia, mild dyspnea, diarrhea, vomiting, anosmia (inability to smell),
             ageusia (inability to taste), sore throat.

          5. Able to provide informed consent.

        Exclusion Criteria:

          1. Illness severe enough to require hospitalization or already meeting study's primary
             endpoint for clinical worsening.

          2. Unstable medical comorbidities including, but not limited to: Severe underlying lung
             disease (COPD on home oxygen, interstitial lung disease, pulmonary hypertension),
             decompensated cirrhosis, Congestive heart failure (stage 3 or 4 per patient report
             and/or medical records).

          3. Immunocompromised (solid organ transplant, BMT, AIDS, on biologics and/or high dose
             steroids (>20mg prednisone per day)

          4. Unable to provide informed consent (eg moderate-severe dementia diagnosis)

          5. Unable to perform the study procedures
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: A Phase 1/2 Study of Ramucirumab Plus Nivolumab in Participants With Gastric or GEJ Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Advanced or recurrent unresectable gastric or GEJ cancer

          -  Histologically confirmed adenocarcinoma (papillary adenocarcinoma, tubular
             adenocarcinoma or poorly differentiated adenocarcinoma), signet-ring cell carcinoma,
             mucinous adenocarcinoma or hepatoid adnocarcinoma

          -  Patients with normal oral intake

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

          -  Patients who have measurable target lesion

          -  Patients has a refractory or intolerant pretreatment by pyrimidine fluoride anticancer
             agent and platinum-based anticancer agent

          -  Patients with adequate organ function

          -  Patients with no pretreatment history including ramucirumab, nivolumab or other
             therapies targeting control of T cells

          -  Patients with written informed consent

        Exclusion Criteria:

          -  Patients have double cancer

          -  Patients have infection required systemic therapy

          -  Known central vervous system (CNS) metastasis

          -  Patients with history of pneumonitis or pulmonary fibrosis

          -  Patients with history of serious anaphylaxis induced by antibody preparation

          -  Patients who have known active autoimmune disease or history of chronic recurrent
             autoimmune disease

          -  Female who is pregnant, lactating or suspected pregnancy

          -  Patients with psychosis or dementia to interfere to obtain informed consent
             appropriately
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Feasibility Assessment of the Blood Pressure Imager, a Continuous Blood Pressure Monitor

Eligibility criteria:
Inclusion Criteria:

          -  Tests will be performed with any adult volunteer who is physically and mentally able
             to perform the experimental tasks.

        Exclusion Criteria:

          -  We will restrict the experiments to adult volunteers who are physically and mentally
             able to consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Statistical Basis for Hemochromatosis Screening

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Eligibility (NLI label): Entailment