Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: A 48-Week, Open Label, Study to Evaluate the Efficacy and Safety of Casimersen, Eteplirsen and Golodirsen in Subjects With Duchenne Muscular Dystrophy Carrying Eligible DMD Duplications

Eligibility criteria:
Inclusion Criteria:

          -  Is a male with DMD and has an out-of-frame duplication of either exon 45, 51, or 53,
             with a normal copy number of all other DMD exons.

          -  Is above age 6 months of age.

          -  Has sufficient muscle mass in a pair of bilateral muscles that will allow for pre- and
             post-treatment muscle biopsies per PI discretion.

          -  If the subject is ambulant and 4 years old or greater and has been on a stable dose or
             dose equivalent of oral corticosteroids for at least 12 weeks prior to Week 1 the dose
             is expected to remain constant (except for modifications to accommodate changes in
             weight) throughout the study.

        Exclusion Criteria:

          -  Any additional missing exon for DMD that cannot be treated with study drugs.

        Other inclusion/exclusion criteria apply
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Value of 25 mcg Cortrosyn Stimulation Test

Eligibility criteria:
Inclusion Criteria:

          -  hypothalamic-pituitary-adrenal disorders

        Exclusion Criteria:

          -  under 18 or older than 65 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Investigation of Clinical Feature and Brain Function in Narcoleptic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Narcolepsy meet to the international classification of sleep disorder,3rd edition
             (ICSD-3) , and RBD meet to the minimal diagnostic criteria according to the
             international Classification of Sleep, control subjects .

        Exclusion Criteria:

        History of heart disease History of central nervous system organic psychosis AHI>15次/h
        History of alcohol dependence and drug abuse
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Mycophenolate Sodium Treatment in Patients With Primary Sjogren's Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of primary Sjogren' Syndrome based on the American-European Consensus
             criteria

          -  Erythrocyte sedimentation rate >25mm/h and hypergammaglobulinemia (>1500 mg/dl)

          -  Presence of anti-SS-A and /or SS-B antibodies and / or rheumatoid factor

          -  Requirement of artificial teardrops due to symptomatic sicca syndrome

          -  Inadequate response or intolerance of prior treatment with hydroxychloroquine and / or
             azathioprine

          -  Adequate contraception for females of childbearing potential

        Exclusion Criteria:

          -  Age below 18 or above 75 years

          -  Secondary Sjogren's syndrome

          -  History of cancer, severe infections or other uncontrolled diseases

          -  Treatment with concomitant disease modifying anti-rheumatic drugs within the least 8
             weeks before baseline evaluation

          -  Prednisolone dose of > 5mg/d or changes of prednisolone dose within the least 4 weeks
             before baseline

          -  Use of secretagogues (e.g. pilocarpine, cevimeline) or medications that potentially
             diminish exocrine gland function (e.g. tricyclic antidepressants, anti-cholinergic
             drugs)

          -  Pregnant or lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Assessment of the Age, Reasons, Oral Health Status and Dental Treatment Needs of Children in Their First Dental Visit

Eligibility criteria:
Inclusion Criteria:

          -  Children with Primary and mixed dentition.

          -  Children visiting the dentist for the first time (first dental visit

        Exclusion Criteria:

          -  Children with systemic diseases or physical and mental problem.

          -  Children whose parents refuse participation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Transition From Alendronate to Romosozumab (AMG 785)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women, defined as no vaginal bleeding or spotting for ≥ 12 months

          -  Low bone mineral density at screening [defined by a bone mineral density (BMD) T-score
             ≤ -2.0 and ≥ -4.0 at the lumbar spine (L1 to L4; or BMD T-score of evaluable
             vertebrae), total hip, or femoral neck]

          -  Currently taking alendronate (70 mg weekly or equivalent) exclusively for ≥ 1 year
             with verbal agreement that the subject has taken ≥ 80% of their doses with good
             tolerance

        Exclusion Criteria:

          -  History of vertebral fracture, or fragility fracture of the wrist, humerus, hip or
             pelvis after age 50; or recent bone fracture within 6 months prior to screening

          -  History of metabolic or bone disease such as Paget's disease, rheumatoid arthritis,
             osteomalacia, osteogenesis imperfecta, osteopetrosis, ankylosing spondylitis,
             Cushing's disease, hyperprolactinemia, and malabsorption syndrome

          -  Vitamin D deficiency (defined as 25-OH-VitD levels < 20 ng/mL)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Watchful Waiting Versus Open Tension-free Repair of Inguinal Hernia in Asymptomatic or Minimally Symptomatic Men

Eligibility criteria:
Inclusion Criteria: men 18 years of age and older with asymptomatic or minimally
        symptomatic inguinal hernias who give informed consent to be randomized.

        -

        Exclusion Criteria:Presence of pain limiting usual activities, difficulty in reducing
        hernia within last 6 weeks, undetectable hernias, local or systemic infection, ASA physical
        status >3, or participation in another clinical trial.

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Role of Tc 99m MDP SPECT/CT in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Adult patient above 30 years old.

          -  Clinically diagnosed osteoarthritis before treatment.

          -  Patient with refractory active osteoarthritis (not responding to treatment).

          -  Ability to sleep in fixed position for about 25 minutes

          -  Ability to provide informed consent.

        Exclusion Criteria:

          -  Patient with resolved osteoarthritis.

          -  patient with other disease in joints:

               -  Avascular necrosis

               -  Stress fracture

               -  Neuropathic pain
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Risks and Outcomes Among COVID-19 Patients Admitted to Assiut University Hospital.

Eligibility criteria:
Inclusion Criteria:

          -  Cases aged 18 years and over. Cases diagnosed as COVID-19 by radiology or with
             positive PCR. Cases admitted to Assiut University Hospitals.

        Exclusion Criteria:

          -  Cases less than 18 years old. Cases diagnosed as COVID-19 and discharged from
             emergency department for Home Isolation. Cases express a dissent from the use of their
             data in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 120 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Safety & Efficacy of Canakinumab (ACZ885) in Patients With Frequent Flares for Whom Nonsterodial Anti-Inflammatory Drug (NSAIDs) and/ or Colchicine Are Contraindicated, Not Tolerated or Ineffective

Eligibility criteria:
Inclusion criteria:

          -  Meeting diagnosis criteria for acute arthritis of primary gout.

          -  Start of acute gout flare within 5 days prior to study visit 1

          -  History of ≥ 3 gout flares within the 12 months prior to study start

          -  Evidence of contraindication (absolute or relative), or intolerance, or lack of
             efficacy for either NSAIDs and/or colchicines

        Exclusion criteria:

          -  Requirement for administration of antibiotics against latent tuberculosis (TB), e.g.,
             isoniazide

          -  Refractory heart failure (Stage D).

          -  Unstable cardiac arrhythmias or unstable symptomatic coronary ischemia

          -  Secondary gout, chemotherapy induced gout, lead induced gout and transplant gout

          -  Rheumatoid arthritis, evidence/suspicion of infectious/septic arthritis, or other
             acute inflammatory arthritis

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction