Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Telerehabilitation Gait Modification

Eligibility criteria:
Inclusion Criteria:

          -  50 years of age or older

          -  Exhibit signs of tibiofemoral osteoarthritis based on a score of ≥2 on the Kellgren
             and Lawrence grading scale predominantly in the medial compartment.

          -  Self-reported knee pain ≥ 3 / 10 on a numerical rating scale of pain (NRS; 0 = "no
             pain" and 10 = "worst pain imaginable") during most days of the previous month

          -  Comfortable walking intermittently for 30 minutes

          -  Fit into the available sizes of sensor shoes (between US women's 5 to men's 13)

          -  Exhibits ≥2% reduction in knee adduction moment impulse at 10 degrees of change in
             toe-in or toe-out during the screening appointment.

        Exclusion Criteria:

          -  Any knee surgery or intraarticular injections within the past 6 months

          -  A history of joint replacement surgery or high tibial osteotomy

          -  Current or recent (within 6 weeks) corticosteroid injections

          -  Use of a gait aid

          -  Currently on a wait list for joint replacement surgery or high tibial osteotomy

          -  Any inflammatory arthritic condition

          -  Any other conditions that may affect normal gait or participation in an aerobic
             exercise program

          -  Cannot attend all required appointments
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Examining the Impact of Tampon Use on the Vaginal Microbiota

Eligibility criteria:
Inclusion Criteria:

          -  regular menstrual cycles lasting 21-35 days

          -  menses lasting for at least 4 days

          -  current tampon user

          -  good self-reported general health

          -  good self-reported vaginal health

        Exclusion Criteria:

          -  currently pregnant

          -  planning to become pregnant in 4 months following enrollment

          -  difficulty using tampons

          -  current toxic shock syndrome

          -  history of toxic shock syndrome

          -  current sexually transmitted infection

          -  current urinary tract infection

          -  currently using antibiotics

          -  antibiotic use in 4 weeks prior to enrollment

          -  current antifungal use

          -  antifungal use in 4 weeks prior to enrollment

          -  autoimmune condition
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium

Eligibility criteria:
Inclusion Criteria:

          -  Women with clomiphene citrate failure (defined as at least prior 5 ovulatory cycles
             with clomiphene citrate, with no conception),

          -  persistently thin endometrium (less than 8 mm in at least 3 cycles).

          -  normal baseline FSH, LH, and free testosterone levels, patent tubes on
             hysterosalpingography, and normal male semen analysis

        Exclusion Criteria:

          -  Women with major medical problems,

          -  male factor infertility,

          -  endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions,

          -  prior ovarian or adnexal surgery, or organic pelvic pathology
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Idiopathic Pulmonary Fibrosis and Serum Bank

Eligibility criteria:
Inclusion Criteria:

          -  Patients seen on an outpatient basis and in stable or acute condition

          -  Patient over 18 years of age.

          -  The inclusion criteria will be those edited by the American Thoracic Society (ATS) and
             the European Respiratory Society (ERS) to diagnosis IPF

        Exclusion Criteria:

          -  Patients who are unable or unwilling to sign the consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: The Plastic Covering Method for Self-gripping Mesh Placement in Laparoscopic Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  Elective laparoscopic inguinal hernia repair

        Exclusion Criteria:

          -  Rejected or withdrawn consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior

Eligibility criteria:
Inclusion Criteria:

          -  US resident age 18+

          -  Member of the partnering consumer research panel conducting the survey

          -  Non-smokers and tobacco cigarette smokers

        Exclusion Criteria:

          -  Age less than 18

          -  Not a member of the partnering consumer research panel conducting the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: A Phase I Study to Assess the Effect of Itraconazole and Rifampicin on Pharmacokinetics Profile of BPI-7711

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged from 18 to 45 years

          -  BMI from 18.5 to 28.0 kg/m2

          -  Medical history, vital signs, physical examination and lab tests are normal or
             abnormal without clinical significance

        Exclusion Criteria:

          -  Subjects with clinical significant diseases

          -  Subjects with allergic disease history

          -  Subjects with gastrointestinal disease history that can affect study drug absorption

          -  Subjects with drug abuse history
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: A Pilot Efficacy and Safety Study of ST101 in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of definite or probable essential tremor (ET) as defined by the Tremor
             Investigational Group with involvement of the hands and arms of at least 2 years
             duration

          -  Tremor severity score of >/= 2 in at least one upper extremity on the
             Fahn-Tolosa-Marin Tremor Rating Scale

          -  Subject who is accessible by telephone

          -  Subject who can comply with study visits, study drug compliance, and study procedures.

        Exclusion Criteria:

          -  Subject whose tremor is adequately controlled on a current treatment

          -  Subject who is pregnant, plans to become pregnant during the study or within 2 months
             of completing the study or who is presently lactating or breast-feeding

          -  Subject with other medical conditions that may cause or explain subject's tremor

          -  Subject with a recent history of hematologic/oncologic disorders

          -  Subject taking medication(s) that might produce tremor or interfere with the
             evaluation of tremor

          -  Subject who has had surgical intervention for their tremor in the past (e.g., ablative
             thalamotomy or gamma knife thalamotomy), or has had a botulinum toxin injection in the
             6 months prior to screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Open-Label Placebo Treatment of Women With Premenstrual Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Moderate to severe PMS

          -  Between 18 and 45 years of age

          -  A regular menstrual cycle, i.e., max. +/- 3 days of difference of cycle range

          -  Menstrual cycle range not longer than 31 or shorter than 24 days

          -  Participants have a general practioner or gynaecologist to consult

          -  At least one premenstrual symptom causes the desire for a PMS treatment

        Exclusion Criteria:

          -  Brest feeding at the moment or during the last three months

          -  Pregnancy

          -  Failing menstruation onset in the course of two consecutive menstrual cycles

          -  An essential mental or somatic disease

          -  Drug or massive alcohol intake or of other psychoactive substances

          -  Uptake of a new medication within the last 30 days

          -  Menopause, premenopausal strain or amenorrhoea

          -  Allergy of one of the ingredients of the placebo dragées (P-Dragees rosa Lichtenstein)

          -  Women who are surgically sterilised, hysterectomised, or ovariectomised

          -  BMI above 30

          -  Actual or recent participation in psychotherapy due to premenstrual symptoms

          -  Parallel participation in another study with investigational drugs or participation in
             another PMS study within the last three months
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Nottingham Osteoarthritis Biomarker Study 2011

Eligibility criteria:
Inclusion Criteria:

        All participants:

          -  Be able to provide written informed consent

          -  Aged 30 and over

        Knee OA patients:

        • Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at
        least one compartment of the knee

        Normal controls:

          -  No knee pain

          -  No clinical or radiographic changes of knee OA
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Eligibility (NLI label): Entailment