Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Investigation of Inflammacheck to Measure Exhaled Breath Condensate Hydrogen Peroxide in Respiratory Conditions

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female, aged ≥16 years

          -  A confirmed, clinician made diagnosis of the following (supported by standard accepted
             diagnostic criteria):

          -  Asthma with a ≤10 pack year smoking history (confirmed by spirometry and/or airway
             inflammation and function tests)

          -  COPD (confirmed by spirometry)

          -  Bronchiectasis (confirmed by CT scan)

          -  Interstitial Lung Disease (confirmed by CT scan and MDT/specialist consensus)

          -  has or is eventually proven to have a histological OR radiological and MDT confirmed
             diagnosis of primary lung cancer, and not yet started treatment for this

          -  current pneumonia (confirmed by chest imaging)

          -  Breathing Pattern Disorder, with no other significant respiratory co-morbidity
             (specialist confirmed)

          -  Healthy controls (defined as no current clinical diagnosis of, or be receiving
             treatment for, a lung or other significant medical disorder).

          -  Willing and able to give informed consent for participation in the study.

          -  In a stable state (at least 4 weeks after treatment of an exacerbation of their
             respiratory disease)

        Exclusion Criteria:

          -  Existing co-morbidities that may prevent them from performing spirometry, for those
             with asthma, COPD, or healthy controls, with no spirometry in the previous 12 months
             (at the discretion of the clinical investigator).

          -  Unable to comprehend the study, provide informed consent, and unable to perform any of
             the study procedures.

          -  Requirement of supplemental oxygen (pneumonia participants only)
No condition on gender to be admitted to the trial.

Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction