Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Restoring Molecular Circadian Rhythm

Eligibility criteria:
Inclusion Criteria:

          -  General good health with the following conditions permissible

               -  cardiovascular risk prevention, intake of low dose aspirin,

               -  hypertension, intake of beta-blockers, ACE inhibitors, diuretics, calcium channel
                  blockers

               -  hypercholesterinemia, intake of statins

          -  Cases: 70-85 years of age

          -  Controls: 20-35 years of age

          -  Patients must be able to read and understand English

          -  Participants must sign the informed consent form

          -  Participants must have a wrist-actigraphy-based average TST (total sleep time) ≥ 6
             hours per night (measured over 7 consecutive days) occurring between 22:00 - 08:00

        Exclusion Criteria:

          -  Known history of severe psychiatric or cognitive conditions, for example mania,
             schizophrenia, or mental retardation

          -  Shift work, defined as recurring work between 22:00-05:00

          -  History of clinically significant obstructive sleep apnea

          -  Transmeridian travel across ≥2 time zones in the two weeks prior to the blood draws
             and one week after,

          -  > 2 drinks of alcohol per day

          -  Use of illicit drugs
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary Fibrosis

Eligibility criteria:
-  INCLUSION CRITERIA:

        Patient:

        Males and females over the age of 18 with a diagnosis of IPF.

        EXCLUSION CRITERIA:

        Patient:

        Female subjects who are pregnant or lactating

        INCLUSION CRITERIA:

        Normal Volunteer:

        Males and females over the age of 18 without IPF.

        EXCLUSION CRITERIA:

        Normal Volunteer:

        Female subjects who are pregnant or lactating
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: Efficacy of a Biodanza Program in People With Alzheimer's Disease.

Eligibility criteria:
Inclusion Criteria:

          -  primary diagnosis of Alzheimer's disease,

          -  never participated in any biodanza session or have knowledge about it.

        Exclusion Criteria:

          -  diagnosis is different from Alzheimer's disease

          -  suffering from a physical or psychological illness that prevents the execution of the
             sessions

          -  do not participate in at least 75% (9 sessions) of the sessions.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Interferon Beta 1a in Hospitalized COVID-19 Patients

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 50

          -  COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed).

          -  Tympanic Temperature of ≥37.5 AND at least one of the following: Cough, Sputum
             production, nasal discharge, myalgia, headache or fatigue) on admission.

          -  Time of onset of the symptoms should be acute ( Days ≤ 10).

          -  SpO2 ≤ 88%

          -  Respiratory Rate ≥ 24

        Exclusion Criteria:

          -  Refusal to participate expressed by patient or legally authorized representative if
             they are present.

          -  Patients with prolonged QT or PR intervals, Second or Third Degree heart block,
             Arrhythmias including torsade de pointes

          -  Patients using drugs with potential interaction with Umifenovir Hydroxychloroquine,
             Lopinavir/Ritonavir or Interferon-β 1a.

          -  Pregnant or lactating women.

          -  History of alcohol or drug addiction in the past 5 years.

          -  Blood ALT/AST levels > 5 times the upper limit of normal on laboratory results.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Development of a Blood Test for Marfan Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Age 4-26 years of age for all participants

          -  Diagnosis of Marfan syndrome, Loeys-Dietz syndrome, vascular Ehlers-Danlos syndrome,
             or Familial Thoracic Aortic Aneurysm and Dissection for inclusion in Marfan and
             Marfan-related disorders groups

          -  Diagnosis of unaffected by Marfan syndrome and Marfan-related disorders for inclusion
             in control group

          -  Able and willing to sign informed consent/assent

          -  Signed HIPPA compliant research authorization

        Exclusion Criteria:

          -  Other known cardiovascular disorder for unaffected controls
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 26 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 18 years of age with atopic dermatitis.

          -  AND presenting active itchy lesions,

          -  Patients with no systemic and / or topical treatment for AD or pruritus.

          -  Patients who gave their written consent

        Exclusion Criteria:

          -  Patients with a physical or psychological disability to sign the consent.

          -  Patients not supported by social security.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Early CPAP in COVID-19 Confirmed or Suspected Patients

Eligibility criteria:
Inclusion criteria:

          1. Adults > 18 years old

          2. Patients living alone or with more than one room at home

          3. COVID confirmed or suspected

          4. To be discharged home or already discharged

          5. One or more of these: fever (>38oC), sore throat, myalgia or flu-like illness

          6. One or more of the following: abnormal chest x-ray, new onset cough, mild hypoxemia
             (saturation between 92-96%), abnormal lung exam, chest tightness or shortness of
             breath

        Exclusion criteria:

          1. Unable to self quarantine for 72 hours if in the CPAP arm

          2. Preexisting pulmonary diseases such as advanced COPD, advanced parenchymal lung
             disease, history of pneumothorax etc.

          3. Claustrophobic and unable to tolerate CPAP mask

          4. Evidence of hypercapnia

          5. Recent heart of lung surgery within 3 months

          6. Individuals without access to smart phones or wireless connection or internet access

          7. Prior history of aspiration

          8. Speech or swallowing impairment (risk of aspiration)

          9. History of stroke with significant neurologic deficit

         10. Advanced symptomatic heart failure

         11. Unable to provide informed consent

         12. household with young children and child care responsibilities

         13. household with high-risk individuals (defined as over 60 or with comorbidities (e.g.
             heart disease, diabetes, pulmonary))
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Comparison of Pureed Rice Using a Gelling Agent and Standard Pureed Rice

Eligibility criteria:
Inclusion Criteria:

          -  hospitalized patients who underwent endoscopic swallowing evaluation at Showa Inan
             General Hospital

        Exclusion Criteria:

          -  an age less than 65 years old or the presence of an acute infection.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Venous Disease Thromboembolic and Amyotrophic Lateral Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  patients with amyotrophic lateral sclerosis defined by revised El Escorial score
             criteria followed in competence centre of Brest Universitary Hospital during 2000 to
             2019

        Exclusion Criteria:

          -  no consent

          -  other neuro-degenerativ diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: A Phase II Multi-centre, Extension Study to Investigate the Long Term Safety of ONO-2506PO in Patients Diagnosed With Amyotrophic Lateral Sclerosis (ALS)

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female patients with diagnosis of ALS over the age of 18 years.

          -  Previous randomization and completion of the last visits in ONO-2506POE014 study.

          -  Patients whom the investigator has no concern and judges tolerable for the continued
             treatment with ONO-2506PO and Riluzole from a risk and benefit point of view.

        Exclusion Criteria:

          -  A clinically relevant medical history or presence of cardiovascular, gastrointestinal,
             renal, hepatic, endocrine/metabolic, neurologic, lymphatic, haematologic, immunologic,
             musculoskeletal, connective tissue, dermatologic, genito/urinary, psychiatric diseases
             or disorders that, in the opinion of the investigator may pose an unwarranted risk to
             the patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Immunomagnetic Detection of Cancer Cells in Pleural Effusion in Lung Cancer Patients as Additional Staging and Prognostic Tool

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 and over

          -  Lung Cancer Patients in the Lung Department or Oncology Department with spread to the
             pleural cavity.

        Exclusion Criteria:

          -  Under age 18
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment