Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Risk Factors for Ectopic Pregnancy: Comparison of Fresh and Warmed Transfers. Analysis of a 10 Years, a Single Center Experience.

Eligibility criteria:
Inclusion Criteria:

          -  Women with diagnosis of EP. Ectopic pregnancy diagnosis was performed with B-hcg
             measurement and imaging visualization of the gestational sac outside the uterus

        Exclusion Criteria:

          -  No case was excluded
Female




Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Does the Volume of the Embryo Culture Medium During Embryo Transfer Affects the IVF Outcomes?

Eligibility criteria:
Inclusion Criteria:

          1. Age ≤ 45y.o.

          2. BMI≤36 kg/m2,

          3. Baseline FSH concentration <15 IU/l,

          4. Ovarian stimulation with the same GnRH antagonist protocol

          5. Normal uterine cavity with endometrium thickness >7mm and trilaminar morphology at the
             Time of transfer and semen

          6. Parameters of >1 million /ml motile spermatozoa with >4% physiological morphology -

        Exclusion Criteria:

          1. PGD cycles

          2. Frozen -thaw cycles

          3. Natural cycles or patients following different ovarian stimulation protocol were
             excluded from the study

             -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Activity and Content of Factor VIII (FVIII) in Human Plasma: The Assessment of a Novel Immunoassay

Eligibility criteria:
Inclusion Criteria:

          -  adults with hemophilia A

          -  factor VIII less that 2%

          -  informed consent signed

          -  absence of an inhibitor

        Exclusion Criteria:

          -  history of a high responding inhibitor anemia
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Multicenter Study on Laparoscopic Distal Subtotal Gastrectomy for Advanced Gastric Cancer (CLASS-01)

Eligibility criteria:
Inclusion Criteria:

          -  Age from over 18 to under 75 years

          -  Primary gastric adenocarcinoma (papillary, tubular, mucinous, signet ring cell, or
             poorly differentiated) confirmed pathologically by endoscopic biopsy

          -  cT2-4a, N0-3, M0 at preoperative evaluation according to the AJCC Cancer Staging
             Manual Seventh Edition

          -  Expected curative resection through distal subtotal gastrectomy with D2
             lymphadenectomy

          -  Performance status of 0 or 1 on ECOG (Eastern Cooperative Oncology Group) scale

          -  ASA (American Society of Anesthesiology) score class I, II, or III

          -  Written informed consent

        Exclusion Criteria:

          -  Women during pregnancy or breast-feeding

          -  Severe mental disorder

          -  History of previous upper abdominal surgery (except laparoscopic cholecystectomy)

          -  History of previous gastrectomy, endoscopic mucosal resection or endoscopic submucosal
             dissection

          -  Enlarged or bulky regional lymph node diameter over 3cm by preoperative imaging

          -  History of other malignant disease within past five years

          -  History of previous neoadjuvant chemotherapy or radiotherapy

          -  History of unstable angina or myocardial infarction within past six months

          -  History of cerebrovascular accident within past six months

          -  History of continuous systematic administration of corticosteroids within one month

          -  Requirement of simultaneous surgery for other disease

          -  Emergency surgery due to complication (bleeding, obstruction or perforation) caused by
             gastric cancer

          -  FEV1<50% of predicted values
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 74 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Progestin Primed Double Stimulation Protocol Versus Flexible GnRH Antagonist Protocol in Poor Responders

Eligibility criteria:
Inclusion Criteria:

          -  1. Indicated infertile women for ICSI of poor responders defined by Bologna criteria
             either two or more of the following:(15) (i) advanced maternal age or any other risk
             factor for POR. (ii) a previous POR ; less than 3-5 oocytes retrieved per cycle. (iii)
             an abnormal ovarian reserve test (ORT): AFC less than 5-7 or AMH is less than 1.1
             ng/ml.

        Or two episodes of POR after maximal stimulation are sufficient to define a patient as poor
        responder in the absence of advanced maternal age or abnormal ORT.

        Exclusion Criteria:

        1. Male factor infertility due to azoospermia. 2. Patients with uncorrected uterine
        pathology. 3. Patients with the diagnosis of severe endometriosis. 4. Patients with BMI
        over 35.

        -
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome

Eligibility criteria:
Inclusion Criteria:

          -  Turner Syndrome or SHOX disorder

          -  SHOX: bone age greater than 10 years for boys, greater than 8 years for girls, Turner:
             bone age greater than 9 years

          -  Height below 3rd percentile or height below 10th percentile and growth velocity below
             25th percentile

          -  Prepubertal: For girls, Tanner stage 1, for boys Tanner stage 1 and testicular volume
             no more than 2 mL

        Exclusion Criteria:

          -  GH deficiency or known insensitivity

          -  Evidence of tumor activity

          -  Diabetes mellitus or history of impaired glucose tolerance

          -  Any severe illness known to interfere growth
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: Activity of Pre-Osteoclasts and Osteoclasts Over Time in Postmenopausal Women Treated With Denosumab or Zoledronic Acid

Eligibility criteria:
Inclusion Criteria:

          1. Women at least 50 years of age who are postmenopausal. Postmenopausal is defined as
             being amenorrheic for at a period of at least 12 months.

          2. Diagnosis of osteoporosis by T score of < -2.5 at either lumbar spine or the
             hip/femoral neck, or osteopenia that qualifies for treatment by FRAX calculation
             (10-year risk of hip fracture > 3% and/or major osteoporotic fracture of > 20%).

        3a. Subjects who have had chronic treatment of denosumab (as defined as > 1 year [at least
        3 6-monthly injections]) or zoledronic acid (defined as ≥ 2 years [at least 2 annual
        injections]) . Note: At the time of treatment initiation, subjects must have met criteria
        for on-label use (e.g. criterion 2 above).

        OR 3b. Subjects who are naïve to treatment with denosumab and/or zoledronic acid.

        Exclusion Criteria:

          1. Renal insufficiency, with glomerular filtration rate (GFR) < 35 ml/min.

          2. Hypocalcemia within 6 months of study initiation.

          3. Known hypersensitivity to denosumab or zoledronic acid.

          4. Medications that could alter bone turnover including prednisone, anti-rheumatic
             medications, anti-metabolites (Cytoxan). Subjects who have been on stable doses of
             thyroid replacement or diabetes medications for more than 3 months are eligible.

          5. Evidence of untreated oral cavities or oral infections. Preventative dental exams
             should be performed before starting denosumab or zoledronic acid. Subjects must avoid
             invasive dental procedures during treatment with denosumab or zoledronic acid.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Prediction of the Efficacy of Activated Recombinant Human Factor VII in Adult Congenital Haemophilia A or B Patients With Inhibitors by Use of Thromboelastography

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of congenital haemophilia A or B with a FVIII:C clot activity or
             FIX:C clot activity, respectively, less than 5%

          -  Presently use of activated recombinant human factor VII (NovoSeven®) as haemostatic
             agent for preventive treatment or treatment of bleeding episodes

          -  A documented historical or present record for the presence of inhibitors to factor
             VIII or IX, respectively

          -  A documented history of 2 or more joint bleeding episodes during the preceding 12
             months

          -  Subjects must be in a non-bleeding state (i.e. no clinical manifestations of active
             bleeds)

        Exclusion Criteria:

          -  Subjects who have received any haemostatic treatment for a bleeding episode within the
             last 7 days prior to this trial

          -  Immune tolerance therapy within the last 30 days prior to this trial

          -  Clinically relevant coagulation disorders other than congenital haemophilia A or B

          -  Thrombocytopenia (platelet count below 60,000 platelets/mcl)

          -  Prophylactic haemostatic treatment within 3 days prior to this trial
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Neuropsychological Assessment of Children and Adolescents With Turner Syndrome

Eligibility criteria:
INCLUSION CRITERIA

        Turner syndrome group :

          -  girls with diagnosed Turner syndrome.

        Isolated GHD group :

          -  girls with diagnosed isolated growth hormone deficiency

        All participants :

          -  age between 7 years to 16 years and 11 months.

          -  informed consent signed by the participant and her parents (or her legal
             representatives)

          -  being registered in the national social security system

        EXCLUSION CRITERIA :

        Turner syndrome group :

          -  patients with chronic pathology other than Turner syndrome.

          -  karyotype : part of a Y chromosome and r(X) cases.

          -  medical treatment other than those usually prescribed in patients with Turner
             syndrome.

        Isolated GHD group :

          -  patients with chronic pathology other than isolated growth hormone deficiency.

          -  medical treatment other than those usually prescribed in patients with isolated growth
             hormone deficiency.

        All participants :

          -  diagnosed intellectual disability (IQ<70) or intellectual giftedness

          -  history of acquired brain injury

          -  sensory disturbances (auditory or visual) incompatible with the achievement of
             neuropsychological tasks.

          -  insufficient French language proficiency
Female
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 16 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Ultra-low Dose Chest Computed Tomography: a Rule-out Tool for Community-acquired Pneumonia

Eligibility criteria:
Inclusion Criteria:

          -  Suspected CAP;

          -  At least one respiratory symptom (new or increasing cough, expectoration, dyspnea or
             chest pain) and

          -  At least one symptom related to infection (fever ≥ 38°C, chills, sweating, myalgia,
             mental confusion or headache) and

          -  Focal auscultatory findings during physical examinations (crackling rales)

          -  No definitive diagnosis possible by clinical judgment.

        Exclusion Criteria:

          -  Score in at least one clinical part of the CURB-65 or PSA scores

          -  Clinical diagnosis of rhinosinusitis and acute nasopharyngitis and who had already
             been treated with antimicrobial therapy for this episode of disease

          -  pregnancy;

          -  the presence of other respiratory diseases such as chronic obstructive pulmonary
             disease (COPD), asthma, interstitial lung disease, chronic diseases or other chronic
             airway conditions;

          -  diagnosis of congestive heart failure;

          -  body mass index (BMI) greater than 30;

          -  inability to hold the breath for at least 10 seconds
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction