Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

Eligibility criteria:
Inclusion Criteria:

          -  Willing and able to provide informed consent

          -  Established a new diagnosis of IPF by the enrolling subspecialty center (as defined by
             ATS/ERS/JRS/ALAT criteria)

          -  Age 30 years or older, or

          -  Diagnosis of a non-IPF ILD of any duration, including, but not limited to Idiopathic
             Non-Specific Interstitial, Pneumonia (iNSIP), Unclassifiable Idiopathic Interstitial
             Pneumonias (IIPs), Interstitial Pneumonia with Autoimmune Features (IPAF), Autoimmune
             ILDs such as Rheumatoid Arthritis (RA-ILD) and Systemic Sclerosis (SSc-ILD), Chronic
             Hypersensitivity Pneumonitis (HP), Sarcoidosis or Exposure-related ILDs such as
             asbestosis with progressive phenotype

        Exclusion Criteria:

          -  Malignancy, treated or untreated, other than skin or early stage prostate cancer,
             within the past 5 years

          -  Currently listed for lung transplantation at the time of enrollment

          -  Currently enrolled in a clinical trial at the time of enrollment in this registry
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Screening of Fabry Disease in Patients With Left Ventricular Hypertrophy Detected in Echocardiography

Eligibility criteria:
Inclusion Criteria:

          -  unexplained left ventricular hypertrophy

        Exclusion Criteria:

          -  isolated septal hypertrophy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Effects of an Herbal Topical Cream on Osteoarthritis Symptoms, Biomarkers, and Disease Progression in the Knee

Eligibility criteria:
Inclusion Criteria:-Men and women between 40-70 years old

          -  Have a history of knee pain

          -  Exhibit mild osteoarthritis on the knee, as determined by Dr. Gold through MRIs and
             radiographs (if available). Exclusion Criteria:-Outside of age range

          -  Prior knee surgery

          -  History of knee or knee ligament instability

          -  History of intermittent or persistent knee joint swelling

          -  History of trauma to the knee or lower extremities resulting in fracture, tears of
             menisci, ligaments or joint capsule, or cartilage damage

          -  Unable to have MRI scan due to the presence of metallic internal devices that would
             represent a risk factor for MRI and known or suspected pregnancy.

        History of corticosteroid use

          -  Kidney Disease

          -  Knee diameter greater than 17cm and body diameter greater than 60 cm due to the
             physical constraints of the MRI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Bone Age Assessment in Children Using Ultrasound Compared to Wrist X-ray

Eligibility criteria:
Inclusion Criteria:

          -  Children 3.5-18 years old refered to the endocrine pediatric clinic due to short
             stature or other growth abnormalities

        Exclusion Criteria:

          -  Children with bone disease

          -  Children who within the last year took medications which might change bone metabolism
             or mineralization
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 42 Months old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect of Intrauterine Injection of Hcg Before ET on Clinical Outcomes in IVF/ICSI Cycles

Eligibility criteria:
Inclusion Criteria:

          -  infertility, male or female factor

          -  Women undergoing ICSI/IVF

        Exclusion Criteria:

          -  functional azoospermia

          -  submucous uterine myomas or previous myomectomy

          -  endometriosis

          -  hydrosalpinges without prior excision or occlusion of the tubal ostia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Metabolic Syndrome and Male Infertility

Eligibility criteria:
Inclusion Criteria:

          -  18 to 45 years-old man

          -  man consulting for primary or secondary infertility, with or without earlier notion of
             paternity

          -  patient insured with a social security scheme

          -  patient who have had a prior medical consultation

          -  patient who have done informed and written consent to participate in the research
             study

        Exclusion Criteria:

          -  patient with problems understanding French

          -  patient smoking more than two-pack-a-day

          -  patient monitoring for viral risk.

          -  man with an unidiopathic infertility which may be explained by:

             1) identifiable factors in direct questioning at the sperm analysis:

          -  exposure to toxic products

          -  infectious disease history

          -  pathological anatomical background 2) factors identified at the etiologic
             investigation: cytogenetic and genetic
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial

Eligibility criteria:
Inclusion Criteria:

          1. A clinical diagnosis by a study investigator of laboratory-supported probable,
             probable, or definite ALS, according to a modified El Escorial criterion (Appendix 2).

          2. 21 to 80 years of age inclusive.

          3. If patients are taking riluzole for ALS, they must be on a stable dose for at least
             thirty days prior to the baseline visit.

          4. Willing and able to give signed informed consent that has been approved by the
             Institutional Review Board (IRB).

        Exclusion Criteria:

          1. Diagnosis of other neurodegenerative diseases (Parkinson disease, Alzheimer disease,
             etc.).

          2. Clinically significant history of unstable medical illness (unstable angina, advanced
             cancer, etc.) over the last 30 days.

          3. Infection with the human immunodeficiency virus (HIV)

          4. Limited mental capacity such that the patient cannot provide written informed consent
             or comply with evaluation procedures.

          5. History of recent alcohol or drug abuse or noncompliance with treatment or other
             experimental protocols. 6 Receipt of any investigational drug within the past 30 days.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient's own account: I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Clinical trial: Impact of Vasculitis on Employment and Income

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a systemic vasculitis: VCRC Patient Contact Registry includes patients
             with Behcet's disease, CNS vasculitis, Cryoglobulinemic vasculitis (Cryoglobulinemia),
             eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (CSS), giant cell
             (temporal) arteritis (GCA), granulomatosis with polyangiitis (Wegener's) (GPA),
             Henoch-Schönlein purpura (IgA vasculitis), microscopic polyangiitis (MPA),
             polyarteritis nodosa (PAN), Takayasu arteritis (TAK), and urticarial vasculitis.

          -  Age ≥18 years old

          -  Living in USA or Canada

          -  Vasculitis diagnosis made ≥1 year ago

          -  Language requirements: questionnaire will be in English only

        Exclusion Criteria:

          -  Inability to provide informed consent and complete survey
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient's own account: I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Clinical trial: Nutritional Stimulation of Growth in Children With Short Stature Without Growth Hormone Deficiency

Eligibility criteria:
Inclusion Criteria:

          -  Ages 3 to 11 years (inclusive).

          -  Must have had normal growth hormone (GH) response (i.e., peak GH concentration ≥10
             ng/mL) to GH provocative tests such as Arginine Insulin Tolerance Test (AITT) or
             Arginine Clonidine Tolerance Test (ACTT).

          -  Pre-pubertal status (i.e. Tanner stage 1 for breast development for girls and
             testicular enlargement for boys and pubic hair for both sexes).

        Exclusion criteria:

          -  Ages younger than 3 years or older than 11 years.

          -  Medical history of a neurologic, endocrinologic, genetic, or metabolic problem known
             to have a direct effect on height growth. This includes, but is not limited to,
             children with Down syndrome, Turner syndrome, Russel-Silver syndrome, Prader-Willi
             syndrome, Pseudohypoparathyroidism, chronic kidney disease, malabsorptive syndromes,
             cancer survivors, etc.

          -  Currently being treated or previously treated with Growth hormone, or history of oral
             steroid treatment within the last 3 months.

          -  Being in puberty.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 11 Years

Eligibility (NLI label): Contradiction