Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Endoscopic Ultrasonographic Staging and Conventional Endoscopic Staging for Depth of Invasion for Early Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Patients with early gastric adenocarcinoma undergo both endoscopic staging and
             endoscopic ultrasonographic staging for depth of invasion

        Exclusion Criteria:

          -  patients had previously received neoadjuvant chemotherapy or chemoradiotherapy

          -  patients with obviously advanced gastric cancer by endoscopy

          -  the evidence of distant metastasis or extensive adjacent organ invasion on abdominal
             CT scan
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Biomarker Study of Previously Treated Lyme Disease Volunteers in Comparison to Healthy Volunteers

Eligibility criteria:
Inclusion Criteria:

          1. Males and females ≥18 years of age.

          2. Able to read, understand, and provide signed informed consent.

          3. Willing to provide blood and stool samples.

          4. Able to communicate adequately and to comply with the requirements for the entire
             study.

          5. Must be willing to discontinue antibiotics 2 weeks prior to sample collection.

          6. If participating in the previously treated Lyme Disease arm, the participants must
             meet the following criteria: 1) Diagnosis of prior Lyme Disease supported by either an
             erythema migrans rash (either classic "bull's eye" or irregular) OR a CDC-positive
             Western blot, 2) previously treated with antibiotics for Lyme Disease, 3) remains ill
             six months or more after receiving preliminary treatment with antibiotics for Lyme
             disease (e.g., fatigue, musculoskeletal pain, or neurocognitive symptoms).

          7. If participating in the healthy volunteer arm, the participants must meet the
             following criteria: 1) must not have had a Lyme Disease diagnosis, 2) in generally
             good health

        Exclusion Criteria:

        1. Unwilling or unable to comply with the protocol (e.g., scheduled visits, laboratory
        tests, other study procedures, and study restrictions).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy

Eligibility criteria:
Inclusion Criteria:

          -  The subject is Chinese

          -  The subject is greater than 50 years of age

          -  The subject satisfies one or more of the following criteria:

               -  has (had) a history of dyspepsia of at least 4 weeks or more. Dyspeptic symptoms
                  include bloating, epigastric discomfort and early satiety

               -  has a family history of gastric cancer

               -  has a medical condition for which an OGD is indicated.

          -  Has past history of intestinal metaplasia or dysplasia

          -  The subject must have personally signed and dated the patient informed consent form
             indicating that he/she has been informed of all pertinent aspects of the study.

          -  The subject must be willing and able to comply with scheduled visits and other study
             procedures

        Exclusion Criteria:

          -  patients who cannot undergo gastroscopies

          -  have a personal history of stomach cancer or surgery

          -  any disabling illnesses

          -  are pregnant or breast-feeding

          -  have bronchial asthma or a known allergy to fluorescein

          -  have renal impairment with serum creatinine above the upper limit of normal

          -  have uncorrected coagulopathy or severe thrombocytopenia precluding biopsy

          -  unable to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Cerebello-thalamo-cortical Coupling in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  age below 75 years

          -  diagnosis of essential tremor according to the criteria of the Tremor Investigation
             Group and the Consensus statement of the Movement Disorder Society Group (ref)

          -  health insurance

          -  signed informed written consent

        Exclusion Criteria:

          -  other neurological disorders

          -  medications that interact with or influence brain excitability

          -  significant brain lesions detected in MRI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3

Eligibility criteria:
Inclusion Criteria:

          -  Otherwise healthy adults aged 18 to 50 years, inclusive

          -  No history of significant ME disease

          -  No history of past ME surgeries

          -  Able to comprehend study risks and provide written Informed Consent

        Exclusion Criteria:

          -  Have any chronic health problem

          -  Have ME fluid or otitis media (OM)at the time of presentation

          -  Have drainage through the tympanostomy tube at the time of testing

          -  Taking any prescription drug with the exception of those for birth control that would
             interfere with study per study MD

          -  Have a known or suspected allergy/adverse reaction to any of the study drugs use to
             prepare the tympanic membrane for ventilation tube insertion or the nasopharynx for
             EMG needle insertion

          -  Have a hearing threshold >15 dB or a >10 dB air-bone gap at any of the speech
             frequencies

          -  Pregnant or nursing

          -  Temporary exclusion: expected need for seasonal allergy med during study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

Eligibility criteria:
Inclusion Criteria:

          -  Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology
             (ACR) criteria and confirmed with X-rays and ACR functional class of I to III

          -  Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs
             (NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at
             least 20 days in the past month

          -  Willing to stop all analgesics for OA pain during the study

          -  Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100
             Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm
             following washout of current Osteoarthritis pain medications at screening

        Exclusion Criteria:

          -  Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs

          -  Arthritis of the knee from other causes

          -  Uncontrolled hypertension

          -  Have OA pain that requires treatment with potent opioids, systemic corticosteroids,
             intra-articular injections, duloxetine, or venlafaxine

          -  Moderate to severe renal impairment

          -  Pregnant or lactating
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: The First Therapeutic Intervention in Malignant Pleural Effusion Trial

Eligibility criteria:
Inclusion Criteria:

          1. Clinically confident diagnosis of malignant pleural effusion requiring pleurodesis.
             The diagnosis may be established by one of:

               -  Histologically proven pleural malignancy OR

               -  Typical features of pleural malignancy seen on direct vision during thoracoscopy
                  OR

               -  Pleural effusion in the context of histologically proven cancer elsewhere

          2. Expected survival more than 1 month

          3. Written informed consent

        Exclusion Criteria:

          1. Age < 18 years

          2. Primary lymphoma or small cell lung carcinoma

          3. Patients who are pregnant or lactating

          4. Inability to give informed consent

          5. History of GI bleeding or of untreated peptic ulceration

          6. Known sensitivity to non-steroidal anti-inflammatory drugs
             (NSAIDs)/opiates/acetaminophen

          7. Hypercapnic respiratory failure

          8. Known intravenous drug abuse

          9. Severe renal or liver disease

         10. Known bleeding diathesis

         11. Warfarin therapy

         12. Current or recent (within 2 weeks) corticosteroid steroid therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy and Safety of Tapentadol Extended Release Tablets in the Treatment of Moderate to Severe Pain in Subjects With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with a clinical diagnosis of osteoarthritis of the knee based symptoms and/or
             radiographic criteria present for at least 3 months

          -  Moderate to severe chronic pain due to knee osteoarithritis

        Exclusion Criteria:

          -  Previously opioid treated subject who had a history of withdrawal after cessation of
             the opioid

          -  History of seizure disorder, psychiatric disease and history of head trauma requiring
             evaluation by hospital based staff, or unconsciousness of unknown origin. Subjects
             who, in the investigator's judgment, have well-controlled depression or anxiety
             disorder may participate

          -  Subjects with history of uncontrolled hypertension (systolic blood pressure > 160 mmHg
             or diastolic blood pressure > 95 mmHg)

          -  Intake of tricyclic antidepressants, serotonin norepinephrine reuptake inhibitors,
             barbiturates, neuroleptics, monoamine oxidase inhibitors, and antiparkinsonian drugs
             within the 30 days prior to the screening visit
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Acute Effect of Inferential Therapy (IFT) and Short Wave Diathermy (SWD) on Balance in Subjects With Knee Pain

Eligibility criteria:
Inclusion Criteria:

          1. Non-specific Knee pain,

          2. osteoarthritis,

          3. chronic ACL and meniscus injury,

          4. patellofemoral knee pain

        Exclusion Criteria:

          1. Recent major surgeries within 6 months,

          2. Limb Length discrepancies, amputation,

          3. any musculoskeletal or neurological limitation preventing evaluation,

          4. vitamin deficiency (B12),

          5. neuropathy,

          6. cancer-related patients,

          7. rheumatoid arthritis,

          8. Osteoporosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 68 Years

Eligibility (NLI label): Entailment