Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Constipation and Gut Transit in DMD Patients

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a diagnosis of Duchenne Muscular Dystrophy (based on clinical
             presentation and verified by compatible muscle biopsy or known dystrophin gene
             mutation).

          -  Age greater than or equal to 18 years old

        Exclusion Criteria:

          -  None
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: The Motor Network in Essential Tremor: Mechanisms of Therapy

Eligibility criteria:
Inclusion Criteria:

          -  Neurosurgical patient populations with essential tremor (main cohort) and Parkinson's
             disease (control cohort)

        Exclusion Criteria:

          -  Non surgical candidates
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal

          -  Hong Kong Chinese women

          -  diagnosed with endometriosis or adenomyosis.

        Exclusion Criteria:

          -  uterine fibroid more than 5 cm

          -  other premalignant or malignant conditions
Female

Subject must be at least 18 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: The GReek Study in the Effects of Colchicine in Covid-19 cOmplications Prevention

Eligibility criteria:
Inclusion Criteria:

        Patients >18 years old with laboratory confirmed SARS-CoV-2 infection (RT PCR) AND body
        temperature >37.5 degrees centigrade AND at least two of: i. sustained coughing, ii.
        sustained throat pain, iii. anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg.

        Exclusion Criteria:

          -  pregnancy, lactation;

          -  known hypersensitivity to colchicine

          -  known hepatic failure

          -  eGFR<20 ml/min

          -  clinical estimation that the patient will require mechanical respiratory support in
             less than 24 hours

          -  any clinical estimation of the attending physician under which the patient shall be
             excluded

          -  QTc > 450 msec (colchicine is not known to significantly prolong QTc, but may interact
             with other medications which prolong QTc).

          -  participation in another clinical trial

          -  under colchicine treatment for other indications

          -  patient who is not likely to comply to study procedures
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Genetic Studies Spermatogenic Failure

Eligibility criteria:
Inclusion Criteria:

          -  Men with oligozoospermia(<2*10^7/ml) or azoospermia

        Exclusion Criteria:

          -  Abnormal karyotypes

          -  Obvious genital trauma history

          -  Genital hernia

          -  Other recognizable causes of male infertility
Male
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Structured Debriefings After Medical Escape Rooms

Eligibility criteria:
Inclusion Criteria:

          -  Medical students who have completed the fourth year of their studies at the University
             of Copenhagen in Denmark

        Exclusion Criteria:

          -  Participants not available for the entire duration

          -  Symptoms indicating viral respiratory disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient's own account: I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Clinical trial: Interhemispheric Plasticity in Humans

Eligibility criteria:
-  INCLUSION CRITERIA:

        Male and female volunteers ages 18-60 years old will qualify for this study. The subject
        population will be equitable and we will strive to enroll volunteers from all ethnic
        backgrounds.

        EXCLUSION CRITERIA:

          1. orthopedic impairments of the upper extremities

          2. neurological impairments, including current or past peripheral or central nervous
             system dysfunction

          3. being on drugs that may lower the seizure threshold

          4. having a pacemaker, an implanted medication pump, a metal plate in the skull, metal
             objects in the eye or skull (for example after brain surgery or shrapnel wounds)

          5. consumption of more than moderate amounts of alcohol or caffeine
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Lipitor Trial To Study The Effect Of Torcetrpib/Atorvastatin To Atorvastatin Alone.

Eligibility criteria:
Inclusion Criteria:

          -  Statin eligible per NCEP ATP-III guidelines

          -  At least 18 years of age

        Exclusion Criteria:

          -  Women who are pregnant or lactating, or planning to become pregnant

          -  Intolerance to statin therapy

          -  Subjects taking any drugs known to be associated with an increased risk of myositis in
             combination with HMG-CoA reductase inhibitors

          -  Subjects with any other medical condition or laboratory abnormality which could affect
             subject safety, preclude evaluation of response, or render unlikely that the subject
             would complete the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Evaluation of GW406381 in Treating Adults With Osteoarthritis Of The Knee

Eligibility criteria:
Inclusion criteria:

          -  Subjects have a primary diagnosis of osteoarthritis of the knee with symptom duration
             of at least 3 months.

          -  Use pain medication, such as a COX-2 inhibitor or NSAID (non-steroidal
             anti-inflammatory drug) at least 5 days per week.

        Exclusion criteria:

          -  History of hypersensitivity or intolerance to pain medications.

          -  History of gastroduodenal perforations and/or obstructions.

          -  History of upper GI (gastrointestinal) ulceration within the previous 6 months.

          -  History of upper or lower GI bleeding within the previous year.

          -  History of inflammatory bowel disease.

          -  Currently take sucralfate or misoprostol.

          -  Currently taking aspirin daily for the heart.

          -  Other restrictions around the use medications apply and would need to be discussed.

          -  History of coronary artery disease, (angina, MI) or surgery.

          -  History of congestive heart failure or renal artery stenosis.

          -  History of stroke or transient ischemic attack.

          -  History of uncontrolled hypertension.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: The Factors Affecting Atopic Dermatitis in Children Age 1-3

Eligibility criteria:
Inclusion Criteria:

          -  children 1-3 age without rash, without atopic dermatitis

          -  children 1-3 age with recurrent atopic dermatitis

        Exclusion Criteria:

          -  children 1-3 age with non-specific rush

          -  children age 1-2 with atopic dermatitis without rush during previous year
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Year old.
Subject must be at most 3 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Chest Ultrasound of ER Patients With Cough or SOB

Eligibility criteria:
Inclusion Criteria:

          -  Presenting to the Emergency Department with cough, wheezing and/or dyspnea (shortness
             of breath)

          -  Referred for CXR and/or CT scan

        Exclusion Criteria:

          -  Life threatening medical condition requiring immediate treatment

          -  Unable to sit up for a chest ultrasound

          -  Unable to consent

          -  Pregnant

          -  Unable to speak, read and write in English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Posterior Parasagittal In-Plane Ultrasound-Guided Infraclavicular Brachial Plexus Block

Eligibility criteria:
Inclusion Criteria:

          -  patient's age between 18 and 80 years old,

          -  American Society of Anesthesiologists (ASA) physical status I - III,

          -  body mass index (BMI) between 20 and 35 kg/m2 and

          -  planned for surgery of the forearm, wrist, or hand.

        Exclusion Criteria:

          -  patient's inability to give consent to the study,

          -  pre-existing neuropathy,

          -  infection at the site of puncture,

          -  coagulopathy, and

          -  allergy to amides local anaesthetics.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment