Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: P75NTR, Diagnostic Biomarker for Alzheimer's Disease: Quantification Study in Cerebrospinal Fluid

Eligibility criteria:
Inclusion Criteria:

          -  patients with AD

          -  patients with MCI due to AD,

          -  patients with frontotemporal dementia

          -  patients with non-neurodegenerative dementia, according to DSM-V and updated National
             Institute on Aging (NIA) recommendations

        Exclusion Criteria:

          -  patients with Parkinson disease or Lewy body dementia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient's own account: I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Clinical trial: Cushing´s Disease Epidemiology in Sweden

Eligibility criteria:
Inclusion Criteria:

          -  All patients registered with Cushing's Disease in Sweden since 1987 in the statistical
             database for in- and out-patients, at the Swedish National Board of Health and Welfare
             will be included in the study.

        Exclusion Criteria:

          -  No
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

Eligibility criteria:
Inclusion Criteria:

          -  Women with hip and wrist fractures within 2 weeks of presentation

          -  Non-fracture controls

        Exclusion Criteria:

          -  Unable to undergo BMD by DXA or high-resolution peripheral quantitative computed
             tomography (HR-pQCT)

          -  History of skeletal metastasis, primary hyperparathyroidism, Paget's disease, multiple
             myeloma

          -  Treatment with bisphosphonate, estrogen (within previous 3 years), teriparatide
             therapy, calcitonin, selective estrogen receptor modulator (SERMs,within previous 3
             years)

          -  Use of glucocorticoids continuously for more than 3 months, use of anticonvulsants

          -  Prior fracture in adulthood (>age 18) for healthy controls

        Amendment to protocol added Arm 2, to include males >50 years with otherwise similar
        eligibility criteria.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Vibration Response Imaging (VRI) in Management and Evaluation in Patients With Pleural Effusion

Eligibility criteria:
Inclusion Criteria:

          -  Able and willing to read, understand, and provide written Informed Consent;

          -  Male or Female in the age range of 18-85 years;

          -  Subject is suspected to have pleural effusion;

          -  Body mass index (BMI) > 21.

        Exclusion Criteria:

          -  Chest wall deformation;

          -  Spine deformation (including severe scoliosis);

          -  Hirsutism;

          -  Potentially contagious skin lesion on the back;

          -  Skin lesion that would interfere with sensor placement;

          -  Cardiac pacemaker or implantable defibrillator;
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Increased Calorie Intake to Reverse Energy Deficiency in Exercising Women: Impact on Bone and Menstrual Cyclicity

Eligibility criteria:
Inclusion Criteria for Ovulatory Control Volunteers:

          -  18-35 years

          -  BMI 16-25 kg/m2

          -  At least 2 hr/wk of aerobic exercise

          -  Gynecological age >/= 5 years

          -  Weight stable (+/- 2 kg) last 6 months

          -  History of regular menses for 6 months

        Inclusion Criteria for Women with Irregular or Absent Menses:

          -  18-35 years

          -  BMI 16-25 kg/m2

          -  At least 3 hr/wk of aerobic exercise

          -  Gynecological age >/= 5 years

          -  Weight stable (+/- 2 kg) last 6 months

          -  No menses within past 3 months or 6 or less menses in last 12 months

          -  Low to normal bone mass (L1-L4 Z score </=0)

        Exclusion Criteria for all participants:

          -  Hormonal contraceptives in last 6 months

          -  Smoking currently

          -  Current clinical diagnosis of an eating disorder

          -  Use of medications incompatible with measurement of reproductive or metabolic
             hormones, including thyroid medications that may interfere with any of the study
             outcomes.

          -  Dietary habits incompatible with prescribed diet for study

          -  Any metabolic, reproductive or bone disease

          -  Sedentary individuals with less than 120 minutes (2 hrs) of activity per week
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: 24 Hour Esophageal and Electrogastrography to Investigate the Mechanism of Reflux Esophagitis

Eligibility criteria:
Inclusion Criteria:

          -  GERD questionnaire with heartburn or acid regurgitation with a frequency at least once
             weekly.

          -  Endoscopic esophagitis.

        Exclusion Criteria:

          -  A history of esophageal, gastric or abdominal surgery.

          -  Gastric or esophageal cancer.

          -  Esophageal varices.

          -  Concomittant severe systemic disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Effect Sildenafil and Estradiiol Valerate on Endometrial Thickness in Infertile Women

Eligibility criteria:
Inclusion Criteria:

          1. Patients having ovulatory infertility.

          2. Age: 20-35 years old.

          3. BMI less than 30 kg/m2

        Exclusion Criteria:

          1. Women who have any congenital uterine anomaly (e.g., unicornuate uterus or infantile
             uterus) or acquired deformities of the uterine cavity that interfere with embryo
             implantation (as Asherman Syndrome).

          2. Women who have any tubal factor that relates to infertility (e.g., tubal adhesion or
             previous ectopic pregnancy).

          3. Women who have contraindication for estrogen treatment (e.g., history of stroke, DVT
             and Benign liver disease).

          4. Women who have male factor for infertility (e.g., azoospermia, teratospermia).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: The Application of Fluorescence Laparoscopy in the Treatment of Adenocarcinoma of the Esophagogastric Junction

Eligibility criteria:
Inclusion Criteria:

        - 1. All cases should be diagnosed as adenocarcinoma of the esophagogastric junctionncer by
        histology. The tumor is within 1 cm above or 2 cm below the anatomic cardia. The clinical
        stage is T1-3, Nx, M0 for gastric cancer which can undergo the laparoscopic surgery.

        2. Eastern Cooperative Oncology Group (ECOG) scale 0-2 3. Heart, lung, liver, and kidney
        function can tolerate operation 4. Patients and their families are able to understand and
        be willing to participate in this clinical study and to sign informed consent.

        Exclusion Criteria:

        1. history of stomach malignant disease 2. recent diagnosis of other malignant tumors
        (except for papillary carcinoma of the thyroid gland and basal cell carcinoma of the skin)
        3. patients with obstruction, perforation, bleeding requiring emergency surgery 4. a
        history of abdominal surgery (which makes it difficult to perform laparoscopic procedures),
        severe systemic disease such as diabetes, severe chronic lung disease, cirrhosis, other
        malignant diseases 5. combined stomach multiple carcinomas 6. with a history of serious
        mental illness 7. pregnant or lactating women 8. The researchers believe that the patients
        are unsuitable to participate in the researchers with other cases.

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication

Eligibility criteria:
Inclusion Criteria:

          -  18 years old and older

          -  Admitted with pleural effusion that undergoes thoracentesis by medical/pulmonary
             service

          -  Pleural fluid pH <7.3

          -  SICU placed chest tube

          -  Subsequent transfer to SICU

        Exclusion Criteria:

          -  Existing malignancy

          -  Malignant cells from initial pleural fluid sample

          -  End stage liver disease (Child's B or greater)

          -  Coagulopathy

          -  Unable to tolerate surgical procedure

          -  Frank purulent drainage (needs OR regardless)

          -  Recent surgery of abdomen or thorax precluding the use of tPA

          -  Baseline neurologic impairment requiring a proxy for consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: REAL-LIFE DATA OF CONSTITUTIONAL VON WILLEBRAND DISEASE IN WESTERN FRANCE (HOPSCOTcH-WILL)

Eligibility criteria:
Inclusion Criteria:

          -  Constitutional VWD patient, of any severity, with or without inhibitors (according to
             the CRMW criteria*),

          -  Patient included in the research database BERHLINGO

          -  Patient treated or not by desmopressin or VWF/FVIII/by-passing agents available on the
             French market (at baseline)

          -  Patient who agrees to participate in the HOPSCOTcH and followed in one of the 5
             investigator HTC

          -  Patient who are not under guardianship

               -  CRMW criteria for constitutional VWD definition:

        Severe forms: VWF:Ag and VWF:RCo <5 UI/dL VWD 2A or 2M: VWF:RCo/VWF:Ag < 0.7 and/or ratio
        VWF:CB/VWF:Ag < 0.7 VWD 2B: unexplained thrombopenia and/or positive RIPA < 0.8 mg/mL (for
        any value of VWF:RCo/VWF:Ag) VWD 2N: FVIII:C/VWF:Ag < 0.6 and reduced to very reduced
        VWF:FVIIIB VWF:Ag <30 UI/dL (in the absence of every previous criteria)

        Exclusion Criteria:

          -  Patients Under guardianship
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment