Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Vital Signs Patch Early Feasibility and Usability Study

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Patient Computer Dialog in Primary Care

Eligibility criteria:
Inclusion Criteria:

          -  Request for an initial appointment with a primary care physician at Beth Israel
             Deaconess Medical Center who has agreed to participate in the study

          -  English as first language

          -  Internet access at home

        Exclusion Criteria

          -  Under 18 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient's own account: I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Clinical trial: Fertility Preservation in Cases of Klinefelter Syndrome.

Eligibility criteria:
Inclusion Criteria:

          -  Klinefelter Syndrome with 47,XXY non-mosaic

          -  Androgenotherapy stopped since more than 6 months

        Exclusion Criteria:

          -  Antecedent of Radiotherapy or chemotherapy

          -  Psychological trouble

          -  Treatment interfering with spermatogenesis

          -  Androgenotherapy non stopped
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: MRI Findings in Inguinal Hernia

Eligibility criteria:
Inclusion Criteria:

          -  age < 50 years

          -  painful inguinal hernia

        Exclusion Criteria:

          -  conditions that do not allow the use of MRI

          -  conditions that prevent general anesthesia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Gout in the ED and Improving Research Participation

Eligibility criteria:
Inclusion Criteria:

          -  Gout diagnosis meeting 2015 American College of Rheumatology and European League
             Against Rheumatism classification criteria,99,140

          -  Adult > 18 years of age, 3) Able to communicate and understand English language (a
             future objective, with additional resources, will include Spanish translation of all
             study materials).

        Key exclusion criteria:

          -  History of specialty care visit for gout (e.g. rheumatology) in the past 2 years

          -  Life expectancy of < 6 months

          -  Past use of pegloticase (as a marker of past extensive gout care)

          -  Current critical illness leading to admission to high acuity medical care unit (ICU,
             stepdown unit) or requiring surgical intervention (general anesthesia) in the 2 weeks
             after ED visit

          -  Concomitant rheumatic disease including infectious arthritis, rheumatoid arthritis, or
             seronegative spondyloarthropathy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient's own account: I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Clinical trial: A Programme for Amyotrophic Lateral Sclerosis Care in Europe

Eligibility criteria:
Inclusion Criteria:

          -  A diagnosis of definite, probable, laboratory supported or possible ALS according to
             the El Escorial criteria.

        Exclusion Criteria:

          -  Patient cognitive impairment to the extent that they cannot complete an informed
             consent process
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Cardiac Autonomic Dysfunction in Diabetics Patients With Syncope

Eligibility criteria:
Inclusion Criteria:

          -  patients with diagnosis of vaso vagal syncope, and left ventricle ejection fraction
             >55%.

        Exclusion Criteria:

          -  patients with neuropathy, arterial hypertension, indications of heart failure and
             coronary heart disease or depression of left ventricle ejection fraction (LVEF < 55%).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Recombinant Factor VIIa (NovoSeven) on Restoring Coagulation Activation

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients with hemophilia A and current antibodies to factor VIII -

        Exclusion Criteria:

          -  Life-threatening hemorrhage

          -  Severe liver failure

          -  Any other severe co-morbidity (including diabetes mellitus, renal failure, cancer,
             septicemia, disseminated intravascular coagulation, crush injury)

          -  Exposure to other haemostatic drugs during the previous 7 days

          -  Hypersensitivity to hamster, mouse or bovine proteins

          -  Known or suspected allergy to NovoSeven or any of its components
Male

Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Effects of Simultaneous Balance and Resistance Training in Older Adults

Eligibility criteria:
Inclusion Criteria:

          -  ability to walk independently without any gait aid

        Exclusion Criteria:

          -  pathological ratings of the Clock Drawing Test (CDT),

          -  Mini-Mental-State-Examination (MMSE, < 24 points),

          -  Falls Efficacy Scale - International (FES-I, > 24 points),

          -  Geriatric Depression Scale (GDS, > 9 points),

          -  Freiburg Questionnaire of Physical Activity (FQoPA, < 1hour)

          -  Frontal Assessment Battery (FAB-D, < 18 points)

          -  any neurological, musculoskeletal or heart-related disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Needlescopic Inversion and Snaring Versus Ligation of Hernia Sac in Girls

Eligibility criteria:
Inclusion Criteria:

          -  Female patients with congenital inguinal hernia (unilateral or bilateral) Hernia
             defect less than 1.5 cm. Age: from 6 months to 10 years old

        Exclusion Criteria:

          -  Male patients Female patients with recurrent inguinal hernia Females below 6-Month
             Hernia defect more than 1.5 cm.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Examining the Feasibility of Collaborative Care Treatment for Overweight Adolescents

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index 90th percentile or greater

          -  One or both parent(s) willing to participate in study assessments and parent sessions

        Exclusion Criteria:

          -  Body mass index 99th percentile or greater

          -  Significant cognitive impairment

          -  Current pregnancy

          -  Congenital heart disease that limits activity

          -  Serious asthma requiring oral prednisone

          -  Taking medications that increase appetite
Female
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 15 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Post-Marketing Non-Interventional Safety Evaluation of Obizur in the Treatment of Bleeding Episodes for Patients With Acquired Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Participant is ≥18 years of age at the time of informed consent.

          2. Participant has AHA, and is being treated/was treated with Obizur.

          3. Participant or the participant's legally authorized representative is willing and able
             to provide informed consent, unless informed consent is not required

        Exclusion Criteria:

          1. Participant has a known anaphylactic reaction to the active substance, to any of the
             excipients, or to hamster protein.

          2. Participant has a concomitant bleeding disorder(s) other than acquired hemophilia A
             (AHA).

          3. Participant has participated in another clinical study involving a medicinal product
             or device within 30 days prior to enrollment or is scheduled to participate in another
             clinical study involving a medicinal product or device during the course of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction