Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis With Early Onset Symptoms

Eligibility criteria:
Inclusion Criteria:

        - Early digital osteoarthritis must combine the clinical AND radiological definition.

        Clinical definition:

        At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a
        digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at
        the time of the first symptoms Clinical symptoms have been changing for less than 3 years

        Radiographic definition:

        The presence of the achievement of at least one PPI and / or IPD. Presence of at least two
        of the following three criteria: pinching, marginal subchondral condensation, marginal
        osteophyte Erosion on radiography is not an exclusion criteria

        - Consent form signed

        Exclusion criteria:

          -  patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other
             inflammatory rheumatism

          -  patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's
             disease; or from congenital disease such as displasie, osteogenesis,

          -  Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score
             (=4) in one joint among the 10 previous sites.

          -  Not able to provide a sample of blood for any reasons

          -  MRI contraindication

          -  Being in exclusion period determined by another previous study

          -  Subject non affiliated to social insurance

          -  Pregnant or lactating women

          -  Vulnerable people based in L1121-5 article of CSP

          -  Elderly subject or protected subjects disabled to give their consent

          -  Subjects private of freedom by court or administrative order
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment