Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Laparoscopic vs Vaginal Hysterectomy for Benign Gynaecological Disease

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing hysterectomy for benign gynaecological disease (e.g., dysfunctional
             uterine bleeding, adenomyosis, fibroids).

        Exclusion Criteria: Women with:

          -  known tubo-ovarian pathology requiring primary laparotomy, e.g. large adnexal masses

          -  known neoplasia requiring pelvic lymphadenectomy

          -  pelvic organ prolapse requiring additional procedures, e.g., uterine procidentia
             (complete prolapse), enterocoele

          -  conditions interfering with laparoscopic surgery, e.g. cardio-pulmonary disease,
             obesity (BMI 30 kg/m2 or more)

          -  large uteri interfering with vaginal hysterectomy (size >16 gestational weeks)
Female
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Treatment Of Supracondylar Fractures Closed Reduction And Circular Ring External Fixation Versus Open Reduction and Internal Fixation

Eligibility criteria:
Inclusion Criteria:

          -  12 and 18 years old

          -  Supracondylar/periarticular humerus fracture needed operative fixation

          -  Fracture is unable to be treated with percutaneous skeletal fixation.

        Exclusion Criteria:

          -  Any previous elbow injury

          -  Osteogenesis imperfecta or another fragile bone disease

          -  Elbow stiffness from another cause

          -  Any pre-existing arm weakness.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Gout Self-Monitoring Aiming to Reach Target

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of gout (as per American College of Rheumatology criteria)

          -  Physician recommendation that escalation of urate lowering therapy with allopurinol or
             febuxostat is appropriate.

          -  Serum urate >0.36mm/L.

          -  Patient has a mobile phone and is able to install GoutSMART application.

        Exclusion Criteria:

          -  Subject is unable to provide consent

          -  Severe renal failure (eGFR <30) or established liver disease

          -  Previous adverse reaction to allopurinol or febuxostat
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient's own account: I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Clinical trial: Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis

Eligibility criteria:
Inclusion Criteria:

        - Patients newly diagnosed with sarcoidosis

        Exclusion Criteria:

          -  Comorbidity responsible for a change in the level of gamma globulin

          -  Other etiology of granulomatosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Comparison of Conservative Methods for the Treatment of Lateral Epicondylitis: A Randomized, Prospective Study

Eligibility criteria:
Inclusion Criteria:

          -  pain over the lateral epicondyle (via palpation over the lateral epicondyle, resisted
             wrist extension, resisted finger extension of the middle finger) for less than
             six-months duration prior to enrollment

          -  conservative treatment of tennis elbow is recommended as standard of care treatment

          -  over the age of 18 and under the age of 65

          -  ability to give informed consent

        Exclusion Criteria:

          -  treatment by a health care profession (MD, physicians assistnat, therapist, or nurse
             practitioner) within the previous 6 months for tennis elbow

          -  congenital deformities, tendon ruptures, or fractures of the elbow within the previous
             12 months

          -  immobility casts or splints within the last 6 months for tennis elbow

          -  co-existing elbow diagnosis (i.e. osteoarthritis or instability)

          -  pregnant women, women trying to get pregnant, or breastfeeding women

          -  under the age of 18 or over the age of 65
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient's own account: I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Clinical trial: Oracea Soolantra Association in Participants With Severe Rosacea

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subject age ≥ 18 years or older;

          -  Subject with a minimum of 20 but not more than 70 inflammatory lesions (papules and
             pustules) of rosacea on the face at Baseline visit;

          -  Subject with severe rosacea with papulopustular lesions (according to the
             Investigator's Global Assessment (IGA) score rated 4);

          -  Female subjects of childbearing potential with a negative urine pregnancy test (UPT);

          -  Female subjects of childbearing potential must practice a highly effective method of
             contraception during the study.

        Exclusion Criteria:

          -  Subjects with particular forms of rosacea or other concomitant facial dermatoses that
             may be confounded with rosacea;

          -  Subjects with more than 2 nodules of rosacea on the face;

          -  Subjects with any uncontrolled chronic or serious disease or medical condition that
             may either interfere with the interpretation of the clinical trial results, or with
             optimal participation in the study or would present a significant risk to the subject;

          -  Subjects with known or suspected allergies or sensitivities to any component of the
             investigational and non-investigational products, including the active ingredients
             doxycycline and ivermectin.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Finhyst 2006: Study on Morbidity of Hysterectomies in Finland

Eligibility criteria:
Inclusion Criteria:

          -  Bening indications for hysterectomy

        Exclusion Criteria:

          -  Malignant indications for hysterectomy

          -  Postpartum hysterectomy
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient's own account: I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Clinical trial: Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Eligibility criteria:
-  INCLUSION CRITERIA:

        Subjects with HPS age 1-80 years are eligible to enroll in this protocol.

        The diagnosis of HPS is based upon a paucity or deficiency of platelet dense bodies on
        whole mount electron microscopy or the identification of pathogenic variants in HPS genes
        by genetic testing. Some subjects who have not been diagnosed with HPS may be admitted to
        the protocol based upon the presence of albinism and a platelet storage pool deficiency.

        Most female subjects who participate in the Obstetrics/Gynecology Questionnaire will be
        enrolled in the protocol.

        Subjects with HPS or family members who are their caregivers participating in the HPS
        Symptom Questionnaire will be at least 18 years of age. These subjects will enroll in the
        protocol and will provide written consent.

        EXCLUSION CRITERIA:

        Infants under age one year are excluded because there is generally no urgency for a very
        early diagnosis and care is more readily provided to older infants at the Clinical Center.

        Pregnant women and adults who are unable to provide consent are excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Year old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Clinical Study on Post Evaluation After Listing of Qizhi Weitong Granules

Eligibility criteria:
Inclusion Criteria:

          1. Metting the diagnostic criteria of functional dyspepsia in Rome IV.

          2. The subjects were informed, and the subjects voluntarily signed informed consent.

          3. The subjects have reading ability.

        Exclusion Criteria:

          1. Patients suffering from gastric ulcer, gastroscopy see bleeding and mucosal erosion,
             pathological examination showed atrophy of gastric mucosa, intestinal metaplasia or
             dysplasia.

          2. Patients with Hp infection positive.

          3. Patients with gastroesophageal reflux disease.

          4. Patients with digestive system organic lesions.

          5. The patient had a history of stomach or abdominal surgery.

          6. Patients had taken the relevant drugs in the past 2 weeks.

          7. Patients suffering from severe illness affecting survival.

          8. Pregnant or lactating women.

          9. Participating in clinical trials of other drugs.

         10. Long term using of sedative hypnotics.

         11. Suspected or true alcohol, drug abuse history.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Dräger COVID-19 Antigen Test Clinical Performance Study

Eligibility criteria:
Inclusion Criteria:

          -  Participants must require SARS-CoV-2 testing for the following reasons:

               -  COVID-19 symptoms (Fever, cough and/or sore throat, fatigue/ general feeling of
                  weakness, loss of sense of smell and/or taste, shortness of breath, muscle
                  stiffness/ body aches, head cold/ running nose, etc.) on the day of testing, or

               -  Known or suspected exposure to SARS-CoV-2 (contact persons etc.), or

               -  Member of a group of high risk of exposure such as healthcare workers etc., or

               -  Require screening for any other reason, e.g. doctor's orders, hygiene directive
                  etc.

          -  Participant must be of legal age and must be able to understand the procedure and
             letter of consent.

        Exclusion Criteria:

          -  Patients younger than 18 years old are excluded from the study.

          -  Pregnant or breastfeeding patients are excluded from the study.

          -  Patients unable to provide written informed consent are excluded.

          -  Patients with bleeding disorder are excluded from the study as a precaution.

          -  Hospitalized patients/inpatients are excluded.

          -  Application of nasal spray within 15 min prior to testing.

          -  Participants with symptoms on the day of testing are excluded, if any of their
             symptoms started more than 14 days prior to testing.

          -  Asymptomatic participants are excluded, if they experienced any symptoms in the 14
             days prior to testing.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment