Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: PET Imaging CCR2 in Lung Inflammation

Eligibility criteria:
Inclusion Criteria:

          -  Men or women 21 years of age or older who have never smoked or current smokers who
             smoked at least 10 cigarettes per day (1/2 pack) and have smoked at least 100
             cigarettes (5 packs) over the past month.

          -  Screening FEV1 and FVC > 80% of predicted

          -  Capable of lying still and supine within the PET/CT and PET/MR scanner for ~1 hour and
             follow instructions for breathing protocol during the CT portion

          -  No illicit drug use or other inhaled drug use (including pharmacologic agents,
             recreational agents, or illicit drugs) within the past year

          -  No known history of cardiac, pulmonary, hepatic or renal disease or diabetes

          -  No history of claustrophobia or other preventing condition that has previously or
             would interfere with completion of protocol specified imaging sessions

          -  Able to comprehend and willing to follow instructions for the study procedures as
             called for by the protocol

          -  BMI ≤ 35

        Exclusion Criteria:

          -  Currently enrolled in another study using an investigational drug

          -  Pregnancy (confirmed by urine pregnancy test)

          -  Active symptoms or history of cardiac, pulmonary, hepatic or renal disease or diabetes

          -  Currently taking any prescription medications

          -  Presence of an implanted device that is incompatible with CT or MRI scanning

          -  Creatinine > 1.30 mg/dL, AST > 50 Units/L, ALT > 55 Units/L, or total bilirubin > 1.2
             mg/dL
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.


Eligibility (NLI label): Contradiction