Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Study of Imaging Characteristics OCT of Skin Lesions Requiring Biopsy / Resection

Eligibility criteria:
Inclusion Criteria:

          -  patients with suspicious skin lesions of malignant tumor (mostly non-melanoma: basal
             cell carcinoma, epidermoid carcinoma and actinic keratoses, or melanoma: melanoma,
             nevi) requiring biopsy / surgical excision;

          -  consent signed

        Exclusion Criteria:

          -  Any dermatosis, hyperalgesic lesion, and / or infected and / or topography making it
             impossible measurements;

          -  pregnant and nursing women

          -  patients under tutorship or curatorship
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Soft Peri-implant Tissue Around Different Abutment Materials

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years

          -  Absence of Systemic Diseases / Disorders

          -  Smoking ≤ 5 cigarettes per day

          -  Periodontally healthy or treated

          -  Full-mouth plaque score (FMPS) ≤ 15% at baseline

          -  Full-mouth bleeding score (FMBS) ≤ 15% at baseline

          -  Presence of edentulous space needing an all on four or all on six treatment with
             overdenture

          -  Width of the keratinized gingiva ≥ 2 at the level of the crest

        Exclusion Criteria:

        (I) • Pregnancy / lactation

          -  Use of systemic antibiotics in the last 3 months

          -  Use of systemic antibiotics as prophylaxis for endocarditis

          -  A chronically treated patient (i.e. 2 weeks or longer) with medicines known to affect
             periodontal tissues (e.g. phenytoin, calcium antagonists, cyclosporine, warfarin and
             non-steroidal anti-inflammatory drugs) the last month before starting the study

          -  Radiotherapy in the neck-head region

          -  HIV, TB, hepatitis or other infectious diseases

          -  Abuse with drugs or alcohol

          -  Smoked cigarettes> 5 cigarettes per day

          -  Untreated periodontitis

          -  FMPS> 15% at baseline

          -  FMBS> 15% at baseline

          -  Implants with peri-implant history

          -  Width of keratinized tissue over crest <2 mm

          -  Need for bone reconstruction around implants to be inserted
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Echo Systemic Sclerosis

Eligibility criteria:
Inclusion Criteria:

          -  Systemic sclerosis diagnosis established by a rheumatologist and met ACR 2012 criteria

          -  Or primary Gougerot-Sjogren patient who met American-European Consensus Group (AECG)
             classification criteria.

          -  Or patient presenting a sicca syndrome but not met Gougerot-Sjogren criteria

        Exclusion Criteria:

          -  History of radiotherapy on face and neck

          -  Infection such as VIH or Hepatitis C

          -  Sarcoidosis

          -  Amylosis

          -  Wearing contact lenses

          -  Hyper IgG4 syndrome
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Evaluation of Prognosis of COVID-19 Patients With Only CT Findings, Only RT-PCR Positivity and Both of Them Positive

Eligibility criteria:
Inclusion Criteria:

          -  Aaged 18 years and over,

          -  Positive for SARS-CoV-2 PCR test and / or Covid-19 treatment with signs of Covid-19
             disease on CT

        Exclusion Criteria:

          -  Patients with negative SARS-CoV-2 PCR test, pneumonia on CT but not given Covid-19
             treatment by not considering Covid-19 by their doctor will not be included.

          -  Patients whose data are not available
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Study to Examine Insulin Resistance During Growth Hormone Treatment for Short Stature Due to Low Birthweight

Eligibility criteria:
Inclusion Criteria:

          -  height < 5%-ile

          -  birthweight < 10%-ile for gestational age

          -  gestation: ≥ 36 weeks

          -  male or female

          -  age: 8-12 years

          -  BMI = 10-90%-ile

          -  normal childhood activity, no physical or other limitations

          -  bone age ≤ 12 years

          -  normal, balanced diet (20-40% calories from fat)

        Exclusion Criteria:

          -  puberty (beyond Tanner Stage 1)

          -  diabetes in subject or first degree relative

          -  sex steroid therapy

          -  chronic conditions requiring medication

          -  other causes of short stature (e.g., Prader-Willi, intracranial lesions,
             hypopituitarism, Turner syndrome, GHD, etc.)

          -  significant systemic disease (pulmonary, cardiac, renal, or other)

          -  non-removable metal

          -  other conditions judged by the investigator to pose a hazard (including history of
             neoplasm)

          -  simultaneous participation in another medical investigation or trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease

Eligibility criteria:
Inclusion Criteria:

          -  symptoms suggestive of GERD or dyspepsia.

          -  Presence of symptom for longer than 6 month

          -  Provision of written informed consent

        Exclusion Criteria:

          -  Any known upper GI disease, other than reflux esophagitis

          -  Active or healing gastroduodenal ulcer (except scars)

          -  History of esophageal or gastric surgery.

          -  Clinically significant heart, lung, liver or kidney disease

          -  Allergy to proton-pump inhibitor

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Diagnostic Efficacy of CNN in Differentiation of Visual Field

Eligibility criteria:
Inclusion Criteria:

          1. Age≥18;

          2. Informed consent obtained;

          3. Diagnosed with specific ocular diseases;

          4. Able to perform visual field test

        Exclusion Criteria:

        Incomplete clinical data to support diagnosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Bilateral Laparoscopic Repair of Groin Hernias With One Large Self-fixating Mesh (ProGripTM)

Eligibility criteria:
Inclusion Criteria:

          -  patients scheduled for primary bilateral inguinal hernia repair

        Exclusion Criteria:

          -  recurrent groin hernia

          -  open hernia repair

          -  unilateral hernias

          -  concomitant repair of another abdominal hernia e.g. umbilical hernia

          -  hernia repair combined with another surgical procedure

          -  emergency operations, like incarcerated hernias

          -  patients under the age of 18 years or over 80 years

          -  ASA score 4 or more

          -  patients unable to perform the QoL assessment, because of language barrier or
             intellectual incapacity

          -  no informed consent of the patient
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Controlled-Release Oxycodone Versus Naproxen at Home After Ambulatory Surgery: A Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Patients scheduled for painful ambulatory surgery (knee arthroscopy, unilateral open
             or laparoscopic inguinal hernia repair)

          -  American Society of Anesthesiologists (ASA) physical classification I or II

        Exclusion Criteria:

          -  cognitive impairment,

          -  preoperative pharmacologic pain treatment

          -  allergy to or a contraindication for taking the study medication (e.g. paracetamol,
             oxycodone, naproxen or another NSAID)

          -  porphyria

          -  pregnancy or lactation

          -  history of severe renal, hepatic, pulmonary, or cardiac failure

          -  current symptoms or history of gastrointestinal bleeding, ileus or chronic obstipation

          -  history of substance abuse, or use of medication with a suppressive effect on the
             central nervous system
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Day Case Inguinal Hernia Repair in Children. Is Laparoscopic Approach Justified?

Eligibility criteria:
Inclusion Criteria:

          -  unilateral inguinal hernia

          -  age age > 4 months, <16 years

          -  fully descended testes

          -  study consent signed

        Exclusion Criteria:

          -  previous abdominal or inguinal surgery

          -  testes not fully descended

          -  not healthy enough for day surgery

          -  age < 4months or >16 years

          -  study consent not signed
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Months old.
Subject must be at most 16 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Wool Clothing for the Management of Childhood Atopic Dermatitis

Eligibility criteria:
Inclusion Criteria:

          -  mild to moderate eczema as determined by a SCORAD of 1-50 at their initial visit

          -  has a legally acceptable representative capable of understanding the informed consent
             document and providing consent on the participants behalf

          -  is capable of returning for review having had education through the Royal Children's
             Hospital eczema workshop

        Exclusion Criteria:

          -  known reactions to wool products

          -  is unable to attend visits

          -  has unstable eczema defined by treatment escalation or increased topical
             anti-inflammatory use in the preceding 2 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 3 Years

Eligibility (NLI label): Entailment