Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Measuring Core Body Temperature Using TempuRing

Eligibility criteria:
Inclusion Criteria:

          1. Participant is willing and able to give informed consent for participation

          2. Females aged 21 to 43 years

          3. Have a body mass index (BMI) above 19 and below 29

          4. Regular menstrual cycles, i.e. no greater than 7 days difference between the shortest
             and longest cycle in the last 6 months

          5. Minimum menstrual cycle 24 days

          6. Maximum menstrual cycle 35 days

          7. Normal pap smear within the last year

          8. Willing to use the fertility device for at least 3 cycles

          9. Willing to fill in online questionnaires

         10. Willing to attend clinic up to 6 times per cycle for transvaginal ultrasound and blood
             tests

         11. Willing to perform LH urine tests at home twice a day from day 8 of cycle until it is
             positive

         12. Willing to document the last day of the previous menses and first day of the following
             menses.

         13. Willing to measure and record oral at the same time each morning.

         14. Normal pelvic ultrasound and blood results obtained during screening tests

        Exclusion Criteria:

          1. Any diagnosed systemic illnesses including thyroid disease, diabetes, yeast infection,
             Chlamydia, gonorrhea, trichomonas, bacterial vaginosis, inflammatory diseases, or are
             in an immuncompromised state

          2. Polycystic ovary disease

          3. Endometriosis or other chronic pelvic pain or pelvic pathology

          4. Taking steroid medication, including oral contraceptives or anti inflammatory drugs

          5. Pregnant
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 43 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Picture-based Computerised Assessment and Training of Cognitive Behaviour Therapy Skills

Eligibility criteria:
Inclusion Criteria:

          -  Intellectual disability

        Exclusion Criteria:

          -  Visual impairments

          -  Auditory impairments

          -  Currently receiving cognitive behaviour therapy

          -  Acute psychosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Rady Children's Institute Genomic Biorepository

Eligibility criteria:
Inclusion Criteria:

          -  All ages, races, genders, ethnicities, and health status will be eligible for
             participation. Enrollment will include that following vulnerable populations: pregnant
             women, neonates, fetuses, those with cognitive disabilities, pediatric patients,
             minorities, and employees.

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: The Anatomic Determinants of Perforation Induced Hearing Loss

Eligibility criteria:
Inclusion Criteria:

          -  Between 18 and 89 years of age

          -  Confirmed diagnosis of conductive hearing loss secondary to tympanic membrane
             perforation

          -  Treated for the above condition by a Duke physician

          -  Received both a CT temporal bone scan interpreted by a Duke radiologist and audiometry
             at a Duke-based facility (both tests performed within four weeks of each other), as
             part of standard pre-operative workup

        Exclusion Criteria:

          -  Temporal CT scan with inadequate resolution as per determination of study staff

          -  Unable to provide written informed consent

          -  Unable to read and understand English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 89 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Comparison Between Desarda and Lichtenstein's Technique for Inguinal Hernia Repair Under Local Anaesthesia

Eligibility criteria:
Inclusion Criteria:

          -  Primary uncomplicated inguinal hernia

          -  Male patients aged more than 18 years and less than 80 years

          -  BMI less than 30kg/sq m

          -  American Society of Anaesthesiologists (ASA) scale less than III

        Exclusion Criteria:

          -  Patients with recurrent, irreducible or strangulated inguinal hernias

          -  Patients unable to interpret VAS or give consent

          -  Patients participating in other clinical trials

          -  Patients with infection in the inguinal region or epididymo-orchitis

          -  Patients allergic to local anaesthetics
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Medication Abortion for Pregnancy of Unknown Location

Eligibility criteria:
Patients with an undesired pregnancy of less than or equal to 42 days gestation based on
        last menstrual period (LMP) who present to Planned Parenthood League of Massachusetts
        (PPLM)'s Greater Boston Health Center seeking medication abortion will be considered for
        study participation.

        Inclusion criteria:

          -  Positive urine or serum hCG test

          -  No evidence of gestational sac on transvaginal ultrasound

          -  Desire for medication abortion as method of pregnancy termination

        Exclusion criteria:

          -  Ineligible for medication abortion at PPLM based on current PPLM clinical guidelines

          -  Reasonable clinical suspicion for ectopic or molar pregnancy, such as abnormal or
             concerning ultrasound findings

          -  High risk for ectopic pregnancy, such as prior ectopic pregnancy, history of tubal
             surgery, concurrent intrauterine device in place during this pregnancy

          -  Exhibiting symptoms of possible ectopic, such as vaginal bleeding or abdominal pain

          -  LMP > 42 days or unknown LMP

          -  Age less than 18 years

          -  Prior participation in this study

          -  Anticipated inability to present for scheduled follow-up visits
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient's own account: I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Clinical trial: Probiotic Bacteria to Infants With Atopic Dermatitis

Eligibility criteria:
Inclusion Criteria:

          -  Atopic dermatitis

        Exclusion Criteria:

          -  Chronic diseases other than atopic dermatitis

          -  Chronic medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 24 Months

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Essential Tremor in Children and Adolescent

Eligibility criteria:
Inclusion Criteria:

          -  Subject whose age is between 3 and 18 years

          -  Subject affiliated to a social security scheme

          -  Parents or subjects who have been informed of the course and consequences of the study
             by an investigator and who have signed the informed consent form for prospective
             inclusion or who have given their non-opposition for retrospective inclusion.

          -  Diagnosis of essential tremor established according to the diagnostic criteria of the
             Movement Disorders Society (1998), by a neuropediatrician or a neurologist, specialist
             in abnormal movements. The diagnosis is based on the presence of the following
             criteria: bilateral action tremor of the hands and forearms, absence of other
             neurological signs.

          -  Availability of an electromyogram for retrospective inclusions.

        Exclusion Criteria:

          -  Abnormal neurological examination outside tremor

          -  Family history or personal dysthyroidism

          -  Existence of a global psychomotor or motor developmental delay

          -  Taking medication that may induce tremor

          -  known poisoning by heavy metals, bismuth, mercury, methyl bromide

          -  Severe appearance of the tremor

          -  Tremor suggestive of a psychogenic origin

          -  Abnormal or non-existent brain MRI if family case
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Use of PRF in Treatment of Dry Socket.

Eligibility criteria:
Inclusion Criteria:

          -  no known medical history of abnormal platelet counts,

          -  patients with symmetric teeth qualified for extraction,

        Exclusion Criteria:

          -  patients treated previously for existing dry socket,

          -  patients allergic to acetylsalicylic acid ,

          -  systemic diseases,

          -  pregnancy,

          -  lactation,

          -  drugs known to affect the number or function of platelets,

          -  abnormal platelet counts,
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Circulating Tumor Cells (CTCs) in Advanced Gastric Cancer

Eligibility criteria:
Inclusion Criteria:

          -  Having signed informed consent

          -  Age≥ 18 years old

          -  Histologically confirmed gastric adenocarcinoma

          -  Preoperative clinical examination and imaging indicating operable disease

          -  complete resection (R0 resection)

          -  D2 or D2+ resection

        Exclusion Criteria:

          -  Other tumor type than adenocarcinoma

          -  Patients who have been given preoperative chemotherapy/chemoradiation.

          -  Staging investigations or intraoperative exploration indicating inoperable disease

          -  R1 or R2 resection

          -  D0 or D1 resection

          -  Patients unreliable for follow up

          -  Past history of malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment