Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient's own account: I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Clinical trial: Study of Voncento® in Subjects With Von Willebrand Disease

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of severe type 1, 2A, or 3 VWD where Von Willebrand Factor: Ristocetin
             Cofactor (VWF:RCo) is <20% at screening

          -  Desmopressin acetate treatment is ineffective, contraindicated, or not available for
             subject (type 3 VWD subjects only).

          -  Evidence of vaccination against hepatitis A and B or presence of antibodies against
             hepatitis A and B due to either a previous infection or prior immunization.

          -  Written informed consent given.

          -  Require a VWF product to control a non-surgical bleeding (NSB) event or for ongoing
             prophylactic therapy.

        Exclusion Criteria:

          -  Known history or suspicion of having VWF or FVIII inhibitors

          -  Acute or chronic medical condition, other than VWD, which may affect the conduct of
             the study

          -  Known or suspected hypersensitivity or previous evidence of severe side effects to
             Voncento, VWF / FVIII concentrates, or human albumin.

          -  Participated in another interventional clinical study within 30 days before the first
             administration of Voncento or at any time during the study.

          -  Females who are pregnant, breast-feeding or who have a positive pregnancy test at
             screening

          -  Alcohol, drug, or medication abuse within 1 year before the study.

          -  Currently receiving a therapy not permitted during the study.

          -  Previous participation in a Voncento / Biostate study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Gut Hormone, Nociceptors, Neurotrophic Factors Expression in Functional Dyspepsia

Eligibility criteria:
Inclusion Criteria:

          -  Subjects who completed upper GI endoscopy and questionnaire about gastrointestinal
             symptoms

        Exclusion Criteria:

          -  Daily user of NSAID or anticoagulants

          -  with concomitant systemic diseases such as diabetes mellitus or any malignancy

          -  Participants with major depression, psychosis, eating disorder

          -  Participants with typical reflux symptom

          -  Patients with Benign gastric ulcer or duodenal ulcer

          -  Patients with past gastrointestinal surgery
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department

Eligibility criteria:
Inclusion Criteria:

          -  Consecutive patients aged 18-65 years who go to the gastroenterology clinic presented
             with upper gastrointestinal discomfort, such as heartburn, regurgitation, dysphagia,
             substernal pain, epigastric pain, epigastric burning, early satiety, postprandial
             fullness.

          -  Whose previous symptoms should last for at least 3 months and be at least 3 days per
             week in frequency with moderate severity.

          -  Able to fill in the questionaires.

        Exclusion Criteria:

          -  gastric or duodenal ulcers, upper GI neoplasms on upper endoscopy

          -  severe cardiac or pulmonary diseases, diabetes or rheumatic diseases

          -  history of operations in the upper GI tract

          -  renal failure or abnormal liver function

          -  use of non-steroidal anti-inflammatory drugs (NSAIDs)

          -  allergy to esomeprazole

          -  Pregnancy or lactating mother
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study of Safety And Efficacy Of ReFacto AF In Previously Untreated Hemophilia A Patients In The Usual Care Setting

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects <6 years of age with severe hemophilia A (FVIII:C <1%) based on clinical
             records, including newborns.

          -  No prior exposure to factor products or any blood products.

        Exclusion Criteria:

          -  Presence of any bleeding disorder in addition to hemophilia A.

          -  Treatment with any investigational agent or device within the past 30 days.

          -  Any condition(s) that compromises the ability to collect study-related observations,
             or that poses a contraindication to study participation (these conditions include, but
             are not limited to, inadequate medical history to assure study eligibility; and
             expectation of poor adherence to study requirements).
Male
No healthy subjects accepted to join the trial.

Subject must be at most 6 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Referred to GLA:D by a physician.

          -  Age ≥ 18y

          -  Chronic knee pain for a minimum duration of 6 months.

          -  Pain intensity ≥ 40mm on a 100mm visual analogue scale (VAS).

          -  Radiographic confirmation of osteoarthritis; Grade 2-4 changes according to the
             Kellgren Lawrence classification system

          -  A decrease of ≥ 50 % in VAS scores with diagnostic genicular nerve block.

          -  Written and oral understanding of Danish.

        Exclusion Criteria:

          -  History of systemic inflammatory conditions such as rheumatoid arthritis.

          -  Previous recipient of cryoneurolysis for the knee.

          -  Use of hyaluronic acid within the previous 30 days.

          -  Injection of corticosteroid within the previous 3 months.

          -  Clinical significant structural abnormities affecting locomotion and knee function
             aside from osteoarthritis and which might cause chronic knee pain.

          -  Body mass index ≥ 18 and ≤ 40 kg/m

          -  In treatment for other pain conditions.

          -  Pregnancy

          -  Coagulopathy

          -  Uncontrolled serious disease (cancer, diabetes, etc.)

          -  Disease associated with reactions to cold, such as cryoglobulinemia, cold urticarial
             and Renaud's syndrome.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: The Effect of Dairy on Bone Mass and Body Composition in 4th-8th Grade Boys and Girls

Eligibility criteria:
Inclusion Criteria:

          -  Males and females in 4th-8th grade

          -  Generally healthy

          -  BMI percentile 5-70% for age or >85% for age

          -  Baseline calcium intake less than or equal to 800mg/d

        Exclusion Criteria:

          -  History of any illness known to affect bone mass accrual (diabetes, inflammatory bowel
             disease, childhood malignancy).

          -  A broken bone in the last six months.

          -  Consume more than 800 mg Calcium/d.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 14 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh

Eligibility criteria:
Inclusion Criteria:

          -  Primary unilateral inguinal hernia

          -  Capacitated male person

          -  Age ≥ 18 years

        Exclusion Criteria:

          -  Concurrent femoral hernia

          -  Incarcerated or strangulated inguinal hernia

          -  ASA 4 or ASA 5

          -  Impaired adequate follow up

          -  Participation in another trial
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy

Eligibility criteria:
Inclusion Criteria:

          -  Diagnostic upper endoscopy performed for medical indications

        Exclusion Criteria:

          -  Upper gastrointestinal surgery

          -  Gastric Cancer

          -  Deep sedation with propofol

          -  Indication of therapeutic endoscopy

          -  Emergency endoscopy

          -  Patients with a history of

               -  Upper gastrointestinal bleeding

               -  Caustic ingestion

               -  Pregnancy

               -  Diabetes mellitus

               -  Asthma

               -  Allergic reactions to medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention

Eligibility criteria:
Inclusion Criteria:

          1. Ages: 21 to 80

          2. Microscopically confirmed premalignant oral epithelial disease

          3. No previous history of cancer (with the exception of basal cell carcinoma of the skin)

          4. Tobacco free for at least six weeks prior to entrance in the trial and remain
             tobacco-free for the three month duration of the study

          5. Availability for necessary study follow-up evaluations (every 10 to 14 days during the
             trial)

          6. Capable of providing informed consent.

        Exclusion Criteria:

          1. Previous history of cancer (with the exception of basal cell carcinoma of the skin)

          2. Current use of tobacco products or refusal to remain tobacco-free for the three month
             duration of the study

          3. Lack of microscopically confirmed premalignant oral epithelial changes

          4. Microscopic diagnosis of oral squamous cell carcinoma

          5. Previous history of radiation therapy on same side of the head and neck region

          6. History of allergy to any kind of berry

          7. Women who are determined to be pregnant or plan to be pregnant during the trial

          8. Women who are nursing.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Dissemination of the Cardiovascular Risk Service

Eligibility criteria:
Inclusion Criteria:

          -  Clinical Staff Subjects:

               -  Must be a current clinic or pharmacy service employee who works as a provider,
                  pharmacist, nurse, clerk or administrator

          -  Patient Subjects:

               -  English or Spanish speaking

               -  Seen in the clinic at least once in the previous 12 months

               -  Currently has one of the following diseases:

                    1. Diabetes with HA1c 9.0% or greater and/or

                    2. Hypertension (uncomplicated) with systolic blood pressure 150 mm Hg or
                       greater

          -  Informal Caregiver Subjects:

               -  Person identified by the patient subject who assists the patient subject with
                  activities of daily living or other aspects of the patient subject's healthcare

        Exclusion Criteria:

          -  Study wide exclusions:

               -  Inability to give consent

               -  Nursing home residence

               -  No telephone

          -  Additional patient subject exclusions:

               -  Cancer with a life expectancy less than 24 months

               -  Pregnancy

               -  Diagnosis of dementia

               -  Plans to terminate care from the clinic within 24 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction