Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Effects of Emicizumab vs. Factor VIII Prophylaxis on Joint and Bone Health in Severe Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  Male gender

          -  Severe hemophilia A (factor VIII < 1%)

          -  Age ≥ 16 year

          -  Either on prophylaxis with factor VIII or emicizumab with the intention to stay on the
             current regimen for the next 3 years

          -  Willing and able to give written informed consent/assent

          -  Willing to undergo MSKUS, DEXA scan +/- collection of blood sampling for repository
             biomarkers

          -  Willing to come in for baseline and 3 yearly visits

          -  Willing to answer phone survey for bleeding and safety every 3 months

        Exclusion Criteria:

          -  Current FVIII inhibitor of > 0.6 BU

          -  Unable to take FVIII replacement

          -  Other known bleeding disorder

          -  Other rheumatologic disorder affecting joints

          -  Other known neuromotor defect (making physical exam difficult)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Hydrotherapy Intervention in Elderly With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  confirmed clinical diagnosis of knee osteoarthritis

        Exclusion Criteria:

          -  total knee arthroplasty

          -  inability to co-operate or follow instructions.

          -  a major neurological disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Dimensional Alterations of the Edentulous Ridge Following Removal of Multiple Adjacent Teeth

Eligibility criteria:
Inclusion Criteria:

          -  presence of an intact extraction socket following removal of the natural teeth defined
             by: a marginal dehiscence defect of the facial bone wall of < 3 mm no facial
             fenestration present apical of the marginal bone crest

        Exclusion Criteria:

          -  Untreated rampant caries and uncontrolled periodontal disease Uncontrolled diabetes or
             any other systemic or local disease or condition that would compromise post-operative
             healing Unable or unwilling to return for follow-up or unlikely to be able to comply
             with study procedures according to investigators judgement.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 90 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: The Effect of Tamoxifen on Clinical Outcome in Women With Thin Endometrium Undergoing Frozen Thawed Cycle.

Eligibility criteria:
Inclusion Criteria:

          1. Women age ≥20 years and ≤40 years;

          2. patients that have at least 1 high quality blastocysts;

          3. patients who are observed endometrial thickness ≤ 7mm in the past natural cycles or
             hormone replacement cycles repeatedly (twice or even more);

          4. patients intends to continue to attempt another frozen embryo transfer cycle.

        Exclusion Criteria:

          1. patients diagnosed intrauterine adhesions, uterine scarring diverticulum via
             Hysteroscopy or ultrasonography and have history of uterine cavity operation for the
             above indication;

          2. patients have congenital uterine anomalies such as Gemini, the mediastinum in the
             uterus and so on.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Effects of Using Divided Mesh and Using a Non Divided Mesh on Testicular Blood Flow and Volume in Laparoscopic Hernia Repair

Eligibility criteria:
Inclusion Criteria:

        Patients with unilateral inguinal hernia Male patients

        -

        Exclusion Criteria:

        Patients have femoral hernia Patients have bilateral inguinal hernia Patients have
        recurrent inguinal hernia Female patients Patients with history of pelvic surgery Patients
        with history of pelvic major trauma Patients with history of pelvic radiotherapy Patients
        have previous scrotal trauma or surgery history Patients have heavy cardiac diseases,
        pulmonary diseases Patients have benign prostate hyperplasia Patients have history of
        incarceration of inguinal hernia

        -
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Clinical trial: Study of the Effect of Once a Week Risedronate on the Microstructure of Tibia and Radius Using a New Scanning Method

Eligibility criteria:
Inclusion Criteria:

          -  cessation of menstruation (surgical or natural) between 6 and 36 months prior to study
             enrollment;

          -  osteopenic

          -  must have at least 1 evaluable radius and tibia, without history of fracture
             (traumatic or atraumatic)

          -  BMI (body mass index) between 18 and 28 kg/m2 inclusive;

        Exclusion Criteria:

          -  history of any generalized bone disease, including hyperparathyroidism, Paget's
             disease of bone, renal osteodystrophy, or any other acquired or congenital bone
             disease; or any known condition that would interfere with the assessment of DXA
             (dual-energy X-ray absorptiometry) at either the lumbar spine (3 non-evaluable lumbar
             vertebrae at lumbar spine L1 - L4) or the femoral neck.

          -  clinical or radiological evidence of osteoporosis, such as atraumatic vertebral
             compression fracture (* 20% reduction in anterior-to-posterior or middle-to-posterior
             height ratio; or 20% reduction of the anterior, middle, and/or posterior height as
             compared with the adjacent vertebrae) documented by spinal X ray or a history of
             osteoporosis-related atraumatic fracture of the hip or of the wrist;

          -  glucocorticoid-induced osteopenia;

          -  previous bisphosphonate therapy;
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 55 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure

Eligibility criteria:
Inclusion Criteria:

          -  Older than 18 years

          -  Positive COVID-19 PCR analysis in pharyngeal swab or in tracheal secretion

          -  Need oxygen supply to maintain SpO2 ≥ 92 %

          -  Able to comply with continuous measurement of SpO2 by pulse oximetry.

        Exclusion Criteria:

          -  Need of oxygen supply > 10 liters/min at admission
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Dysphagia Handicap Index: A Structured Translation From English to German

Eligibility criteria:
Inclusion criteria: All patients with dysphagia

        Exclusion criteria: Inability to fill in the questionnaire
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient's own account: I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Clinical trial: Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track

Eligibility criteria:
Inclusion Criteria:

          -  2 consecutive spermograms (with ±3 months interval) confirming absence of sperm
             (azoospermia)

          -  diagnosis of non-obstructive azoospermia on the basis of a complete history, physical
             examination, endocrine profile, ultrasound and chromosomal analysis

        Exclusion Criteria:

          -  History of previous testicular surgery, except orchiopexy for undescended testis.

          -  Monochordy

          -  Ultrasound revealed testicular nodule

          -  Y chromosome microdeletions type AZFa and b.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: A Novel Selective Block of the Suprascapular Nerve

Eligibility criteria:
Inclusion Criteria:

          -  Patients with American Society of Anesthesiologists physical status (ASA) I- III

          -  age between 18 and 70 years

          -  body mass index between 20 and 36 kg/m2 scheduled for elective hand surgery.

        Exclusion Criteria:

        We will measure the angle between wrist and horizontal plane while the patient is supine
        and the extended arm 75° abducted.

          -  Patient who are not able to pronate the hand ≤15° before block performance, will be
             excluded from the study.

          -  Patients will also be excluded if they are pregnant, have contraindications to
             regional anesthesia, coagulation disorder, allergy to local anesthetics (LA),
             atrioventricular block, peripheral neuropathy or drug-treated diabetes.

          -  Patients using other anticoagulation drugs than acetylsalicylic acids or dipyridamol
             will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: The Efficacy of Fenugreek Supplementation on Men's Health: A Randomized Controlled Trial

Eligibility criteria:
Inclusion Criteria:

          -  Healthy men between the ages of 21- 45 that were recreationally active.

        Exclusion Criteria:

          -  Above 30% body composition, not in the age range, history of asthma, diabetes,
             hypoglycemia, or took any hormonal supplements such as testosterone or anabolic
             steroids.
Male
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction