Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Histopathological Evaluation of Product of Conception in Sporadic and Recurrent Abortions

Eligibility criteria:
Inclusion Criteria:

          -  all pregnants with clinical symptoms and signs of abortion

          -  fit for medical induction of abortion

          -  fit for surgical procedure

        Exclusion Criteria:

          -  threatened abortion

          -  complete abortion

          -  unfit participants for medical abortion

          -  unfit participants for surgical procedure
Female
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Performance Evaluation of SARS-COV-2 (Covid-19) Antigen Rapid Test

Eligibility criteria:
Inclusion Criteria:

        1. Up to 200 subjects will be screened, consented, and enrolled to obtain a minimum of 60
        eligible candidates. In order to be eligible to participate in this study, an individual
        must meet all of the following criteria:

          1. Provision of informed consent

          2. Subject is a suspected case of COVID-19 by clinical criteria: a patient with acute
             respiratory tract infection (sudden onset of at least one of the following: cough,
             fever, shortness of breath, fatigue, decreased appetite, myalgia) AND with no other
             etiology that fully explains the clinical presentation, with or without a history of
             close contact with a confirmed or probable COVID-19 case in the 14 days prior to onset
             of symptoms.

          3. Subject is an appropriate candidate for Nasopharyngeal sample collection. d/. Subject
             is willing to provide nasopharyngeal swab samples.

        Exclusion Criteria:An individual who meets the following criterion will be excluded from
        participation in this study:

        1. Individuals who present with 10 or greater days of COVID-19 Related Symptoms, (Fever,
        Cough, Fatigue, Decreased Appetite, Shortness of Breath, Myalgia) or post-defervescence
        and/or convalescence.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effects of an Swallowing and Oral Care Program in Patients Following Prolonged Endotracheal Intubation

Eligibility criteria:
Inclusion criteria

          -  Adult patients (50 years old and older)

          -  People who had been extubated for over 48 hours and successfully extubated

          -  People or their legal representative who agree to participate in this study and sign
             the permit

          -  People who can communicate with Mandarin or Taiwanese

        Exclusion criteria

          -  People who have diagnosis of neurological diseases such as cerebrovascular disease,
             Parkinson's disease or spinal injury, etc.

          -  People who have abnormal structure or function of oropharynx such as patients with
             head neck cancer or acquired/ inherited abnormal oropharynx structure

          -  People who currently have endotracheostomy

          -  People who are unconscious or have mental disability, having difficulty following the
             protocol or interacting with others

          -  People who are absolute quarantined. such as patients with open tuberculosis

          -  People who had swallowing difficulties before current intubation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Comparison of Platelet Rich Plasma and Alternative Therapies for the Treatment of Tennis Elbow (Lateral Epicondylitis)

Eligibility criteria:
Inclusion Criteria:

          -  Adult man or woman aged 18 years or greater.

          -  Clinical diagnosis of lateral epicondylitis based on site of pain, pain elicited with
             active extension of the wrist in pronation and elbow extension.

          -  Documented sonographic diagnosis of common extensor tendinosis based on tendon
             thickening, areas of hypoechogenicity, and loss of the normal echotexture.

          -  Chronic symptoms (equal or greater than 3 months).

          -  Pain of at least 5 out of 10 on a visual analog scale (VAS).

          -  Provision of informed consent.

        Exclusion Criteria:

          -  Acute symptom onset (less than 2 months).

          -  History of acute elbow trauma (less than one week).

          -  History of rheumatoid arthritis.

          -  History of malignancy.

          -  Pregnancy

          -  Patients requiring anti-platelet medication for the treatment of heart attack, stroke
             or other medical condition.

          -  Previous surgery for lateral epicondylitis.

          -  Previous local injections, including steroids within the past 6 months.

          -  Signs of other causes for lateral elbow pain (posterior interosseous nerve entrapment,
             osteochondral lesion).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Quantifying and Understanding the Signs and Symptoms of Fever

Eligibility criteria:
-  INCLUSION CRITERIA PHASE I:

        Adult and pediatric medical-surgical patients hospitalized in the Clinical Center, NIH
        admitted to 3NE (oncology/ transplant), 3NW (surgical oncology) and 1NW (pediatrics).

        Oriented to person, time and place at time of interview

        Active fever (body temperature greater than or equal to 38.0 Celsius), treated or
        untreated, within the last 12 hours.

        Willingness to participate in a short interview (15-20 minutes) about their symptoms

        Understands and speaks English

        Age 8 years and older

        INCLUSION CRITERIA FOR STUDY OF FEBRILE ASSESSMENT TOOL:

        Adult (18 years of age or greater) medical-surgical patients hospitalized at the Clinical
        Center and admitted to 3NW.

        Oriented to person, time and place at time of admission

        Willingness to be asked about their symptoms of fever during vital signs assessment

        Understands and speaks English

        INCLUSION CRITERIA PHASE II:

        Inpatients admitted to the Clinical Center

        Age 8 years and older
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with knee osteoarthritis based on clinical and radiographic criteria of
             American College of Rheumatology

          -  Osteoarthritis signals in at least one of the compartments of the knee joint
             (tibiofemoral and / or the patellofemoral joint)

          -  Do not perform regular physical activity - less than three times a week regularly

          -  Grade 2 or 3 according to the criteria of Kellgren & Lawrence knee osteoarthritis
             radiographic examination scale.

          -  Minimum score of 4 cm in Visual Analogue Scale (total 10 cm)

          -  Body Mass Index less or equal to 45 kg/cm2

        Exclusion Criteria:

          -  Physical therapy within 3 months prior to the research project

          -  Corticosteroid injection in the knee (in the previous 6 months)

          -  Medical condition (cardiorespiratory, neurological and / or musculoskeletal)

          -  Previous ankle, knee or hip surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient's own account: I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Clinical trial: Tunneled Pleural Catheter in Partially Entrapped Lung

Eligibility criteria:
Inclusion Criteria:

          -  One-sided malignant pleural effusion, first occurrence, or following repeated
             pleuracentesis

          -  History of dyspnea relieved after pleuracentesis

          -  Patient is suitable for VATS

          -  Surgery is indicated by diagnostic necessity

          -  Ability of subject to understand character and individual consequences of clinical
             trial

          -  Written informed consent must be available before enrolment in the trial

          -  For women with childbearing potential, adequate contraception.

          -  Histological proven pleural carcinosis by immediate sectioning

          -  Intraoperative: partial entrapment of the lung

        Exclusion Criteria:

          -  Prior lobectomy or pneumonectomy on the affected side

          -  The patient is not operable for general reasons or Karnofsky performance score < 50

          -  Intraoperative suspicion of a pleural empyema

          -  Chylothorax

          -  Prior attempts at pleurodesis

          -  Intended or prior intrapleural chemotherapy or radiotherapy

          -  Pregnancy and lactation

          -  Participation in other competing clinical trials and observation period of competing
             trials
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Exercise Versus DDAVP in Patients With Mild Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          -  1) Patients of ≥13 years of age and ≤21 years of age with MHA (FVIII:C level of ≥6% to
             ≤50%).

        Exclusion Criteria:

          1. A currently circulating or a history of inhibitor (0.5 BU on two or more occasions).
             Inhibitor development is rare in MHA.

          2. History of FVIII infusion (both standard-acting and extended half-life products) or
             DDAVP use in preceding 1 week. Patients will be instructed to hold factor use or DDAVP
             for 1-week prior to participation in study, except for management of acute bleeds, in
             which case they will be instructed to inform the PI via telephone or e-mail.

          3. Patients with severe arthropathy (as determined by the principal investigator)
             interfering with ability to exercise. Severe arthropathy is rare in MHA.

          4. Patients on beta-blockers, anti-platelet agents or regular non-steroidal
             anti-inflammatory medications (e.g. Celebrex).

          5. Patients who are active smokers (cigarettes, marijuana).

          6. Patients with a history of a recent bleed (in preceding 2 weeks) in any location or a
             joint/muscle bleed in the lower limbs in the preceding 4 weeks.

          7. Co-existence of a congenital bleeding disorder other than MHA (e.g. VWD).

          8. Patients with an active infectious or inflammatory condition. This includes previously
             identified HIV, active hepatitis B or C as reflected in elevated AST, ALT, RNA
             positivity for hepatitis B or C. HIV, hepatitis B and C are very rare in the age group
             (13-21 years) we hope to accrue in the proposed study.

          9. Patients who for medical reasons should not receive DDAVP [those with renal or CNS
             disease (e.g. brain tumor)] or have previously experienced adverse events with DDAVP
             (e.g. hypotensive event, seizure).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 21 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans

Eligibility criteria:
Inclusion Criteria:

          -  Subject age 18 and older

          -  Subject with a diagnosis of LPP, EDP, or AD

          -  Subject able to understand requirements of the study and risks involved

          -  Subject able to sign a consent form

          -  Subject to have discontinued all topical or oral medications, with the exception of
             sunscreen, used to treat pigmentary abnormalities one month prior to treatment

        Exclusion Criteria:

          -  Personal history of clotting disorder or thromboembolic disease (deep vein thrombosis
             (DVT), stroke, etc)

          -  Active malignancy, excluding non-melanoma skin cancer

          -  Moderate to severe renal impairment

          -  History of migraine with aura

          -  Current anticoagulant therapy

          -  Current use of hormonal contraception or hormone replacement therapy in the last 30
             days

          -  A woman who is lactating, pregnant, or planning to become pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction