Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Follicle-Stimulating Hormone (FSH) and the Onset of Puberty

Eligibility criteria:
Inclusion Criteria:

        Early Puberty Children who have early puberty may participate in this study. Children must
        be between 6 and 10 years of age and be healthy with the exception of having early puberty.
        For early puberty, girls should have had the onset of breast development prior to 8 years
        of age and boys should have the onset of pubic hair growth or genital growth prior to 9
        years of age.

        Inclusion Criteria for Delayed Puberty Children who have late (delayed) puberty may
        participate in this study. Children must be between 12 and 17 years of age and be healthy
        with the exception of having late puberty. In order to have late puberty, boys and girls
        should have short stature compared to their family with at least one year delay in bone age
        as determined by bone age x-ray and/or have the onset of secondary sexual characteristics
        (breast and pubic hair growth) at 12 years of age or later for a girl or 13 years of age or
        later for a boy.

        Exclusion Criteria:

        Early Puberty Children with known genetic disorders, chronic medical conditions requiring
        the use of steroids, and use of medication for puberty within the last 3 months are
        excluded.

        Delayed Puberty Children with known genetic disorders with the exception of possible
        hypogonadotropic hypogonadism, chronic medical conditions requiring the use of steroids,
        and use of medication for puberty within the last 3 months are excluded.

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 17 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Wearable Sensor to Monitor COVID-19 Like Signs and Symptoms

Eligibility criteria:
Inclusion Criteria:

          -  Ages between 18-95 years old

          -  Currently experiencing any COVID-like signs and symptoms such as fever, cough,
             shortness of breath, trouble breathing, persistent pain or pressure in the chest,
             confusion or inability to arouse, bluish lips or face.

          -  Individuals who are not experience any COVID like signs and symptoms (will be asked to
             be healthy control)

          -  Able and willing to give written consent and comply with study procedures.

        Exclusion Criteria:

          -  Inability to understand instructions and follow a three step command.

          -  The subject is pregnant, nursing or planning a pregnancy.

          -  Inability to provide written consent.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 95 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient's own account: I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Clinical trial: Physiology of Weakness in Movement Disorders

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Both patients and healthy volunteers will be between age 18 and 80.

          -  Patients will be evaluated in the Human Motor Control Clinic at NINDS.

          -  The definite diagnosis of the disease may not be completely established at the time of
             recording.

          -  Patients have clear and reproducible symptoms of give way weakness of either upper or
             lower extremities.

          -  Patients have to be able to resist against the examiner for at least two seconds
             before giving way.

          -  Healthy volunteers are right handed adults without history of neurological disease or
             severe head trauma.

        EXCLUSION CRITERIA:

          -  Subjects (patients or volunteers) who cannot understand the instructions and consent
             forms of the protocol will be excluded.

          -  Subjects who cannot follow the instruction during the entire recording for whatever
             reason will be excluded.

          -  Patients with a documented organic central nervous system lesion may be excluded from
             the study. This will be discussed in detail for each individual subject at the Human
             Motor Control Clinic.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Routine Pathological Examination of Hernia Sac; Is it a Workload or Necessary?

Eligibility criteria:
Inclusion Criteria:

          -  Emergency operated patients

          -  Elective operated patients

        Exclusion Criteria:

          -  Hernia repairs without pathology examinations
No condition on gender to be admitted to the trial.




Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with clinically uncertain Parkinsonian Syndromes or monosymptomatic, atypical
             or incomplete presentation of tremor, rigidity, bradykinesia or postural instability.

          -  Onset of clinical manifestations within the last 5 years

        Exclusion Criteria:

          -  Differential diagnosis between Parkinsons´s Disease and Progressive Supranuclear Palsy
             or between Parkinson´s Disease and Multiple System Atrophy

          -  Subjects with an established/certain movement disorder clinical diagnosis

          -  Presence of known causes of tremor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia

Eligibility criteria:
Inclusion Criteria:

          1. Adult patients

          2. Patients physically able to participate in the clinical trial.

          3. Patients diagnosed with Sjogren's syndrome using 2016 ACR/EULAR classification
             criteria (Shiboski et al., 2017).

          4. Secondary sjogren patients with rheumatoid arthritis.

          5. Patients with clinical oral dryness positive scores.

        Exclusion Criteria:

          1. Patients with previous radiotherapy.

          2. Patients not approved to participate in the clinical trial.

          3. Patients didn't complain from xerostomia.

          4. Patients with diabetes mellitus.

          5. Patients taking drugs caused xerostomia as antidepressants, anticholinergics,
             antihistamines, and anxiolytics and antihypertensives (Campos et al., 2019).

          6. Patients with symptomatic oral lesions
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Testosterone in Bariatric Patients

Eligibility criteria:
Inclusion Criteria:

          -  Eligible for bariatric surgery according to the Danish national criteria (i.e. aged
             18-60 years, BMI >35 kg/m2 with specific secondary disease or BMI >40 kg/m2 with
             significant health issues assessed by the multidisciplinary bariatric team) [42]

          -  Caucasian men

          -  Total testosterone < 12.0 nmol/l

          -  No contraindications for testosterone treatment

        Exclusion Criteria:

          -  Previously diagnosed with prostate, mammae or liver cancer. Any other cancer within
             the last 5 years.

          -  Hypersensitivity to the active substance or to any of the excipients in Nebido®

          -  Symptomatic heart disease NYHA >2

          -  Recently thromboembolic disease <3 months

          -  PSA >4.0 ug/l or PSA>3.0 ug/l and lower urinary tract symptoms

          -  Disability that severely affect the ability to perform exercise training

          -  EVF > 52%
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient's own account: I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Clinical trial: A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus

Eligibility criteria:
Key Inclusion Criteria:

          -  Written informed consent, authorize release and use of protected health information

          -  At least 18 years of age

          -  Diagnosis of moderate to severe mucosal lichen planus

          -  No systemic (oral or injectable) treatment of lichen planus for 4 weeks prior to
             starting study drug.

          -  Willing to forgo changes in topical treatment (creams) for 4 weeks before receiving
             the study drug and during the course of the study.

          -  Off of topical tacrolimus or pimecrolimus for 4 weeks prior to starting the study drug

          -  CD4+ T lymphocyte counts must be above the lower limit of normal laboratory value

        Key Exclusion Criteria:

          -  Clinically significant abnormal laboratory values

          -  Skin lesions currently undiagnosed, but suspicious for malignancy

          -  Other skin disease that might interfere with lichen planus status assessments.

          -  History of malignancy other than basal cell carcinomas or fewer than 3 squamous cell
             carcinomas

          -  Exposure to systemic therapy for lichen planus within 4 weeks prior to enrollment.

          -  Previous exposure to alefacept
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Earlier Triggering in Rec-FSH/GnRH Antagonist Cycles

Eligibility criteria:
Inclusion Criteria:- Age ≤ 39 years

          -  Body mass index between 18 and 29 kg/m²¬

          -  Presence of both ovaries

          -  Basal levels of estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the
             cycle

          -  Treatment with IVF/ICSI

          -  Embryo transfer on day 3 (1 or 2 embryos)

          -  Patients can enter in the study only once

        Exclusion Criteria:

          -  Presence of endometriosis stage ≥3(AFS)

          -  Polycystic ovarian syndrome (Rotterdam criteria)

          -  Need for preimplantation genetic diagnosis (PGD)

          -  Azoospermia testicular sperm extraction (TESE)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient's own account: I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Clinical trial: Progenitor Cells in Human Esophagus

Eligibility criteria:
Inclusion Criteria:

          -  ≥ 18 years old

          -  Esophagus surgery at Mayo Clinic

        Exclusion Criteria:

          -  <18 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment