Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Efficacy of Levetiracetam in Essential Tremor

Eligibility criteria:
Inclusion Criteria:

          -  History of tremor for 5 or more years

          -  No other neurological problems

        Exclusion Criteria:

          -  Prior stroke or other neurological disease, psychiatric problems

          -  History of renal disease

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe)

Eligibility criteria:
Inclusion Criteria:

          -  Age-matched (18-100)

          -  Healthy normal controls with no known hearing loss

          -  Patients with clinically assessed hearing loss

        Exclusion Criteria:

          -  Complete hearing loss/deafness

          -  Cognitive decline or dysfunction, dementia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Evaluation of a New Blood Pressure Measuring Device.

Eligibility criteria:
Inclusion Criteria:

          -  Male or female, age 18 years or above

          -  Signed written informed consent

        Exclusion Criteria:

          -  A history of cardiac arrythmia

          -  Wrist circumference smaller than 13cm or larger than 19.5cm

          -  Documented peripheral vascular disease

          -  Damage or injury to the left wrist

          -  Participation in any other clinical study

          -  Any acute coronary of cardiovascular illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Treatment of Hemochromatosis

Eligibility criteria:
-  INCLUSION CRITERIA:

        Confirmed diagnosis of HH, defined by the following HFE genotypes: C282Y/C282 or
        C282Y/H63D. Up to 50 percent of the total study population may have received prior
        phlebotomy therapy.

        Elevated transferrin saturation and/or ferritin level, but diagnosis of HH not yet
        confirmed by genotype or liver biopsy.

        Elevated transferrin saturation and/or ferritin level without genotype findings listed
        above, but with elevated hepatic iron index on liver biopsy.

        Family member screening (unknown HH phenotype or genotype)

        EXCLUSION CRITERIA:

        Age less than 15 years.

        Pregnancy.

        Patients requiring therapeutic phlebotomy for reasons other than iron overload
        (polycythemia vera).

        Patients with iron overload not due to HH (e.g. hepatitis C infection, porphyria cutanea
        tarda, Wilson s disease, alpha-1-antitrypsin deficiency, alcohol abuse).

        Other medical illness or condition which, in the opinion of the Investigators, may
        contraindicate participation due to risk to patient or to Donor Center.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Transversus Abdominis Plane Blocks for Infants and Children for Postoperative Pain Control

Eligibility criteria:
Inclusion Criteria:

          -  Children under 8 years of age presenting for hernia repair, hydrocelectomy or lower
             abdominal surgery

          -  Estimated operative time approximately 3 hours

          -  American Society of Anesthesiologists Classification ASA I or II

          -  Parental consent to be included in the study

        Exclusion Criteria:

          -  Any contraindications to local anesthesia but not limited to

               1. Local infection of the abdominal wall.

               2. Allergy to amide local anesthetics

               3. History of significant cardiac disease or uncontrolled seizures.

               4. Allergy to rescue analgesia including acetaminophen and or hydromorphone.

               5. Neonates under 28 days.

          -  Inability for the family to complete the postoperative questionnaire
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 8 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Quality of Recovery After General or Spinal Anesthesia for Inguinal Hernia Repair

Eligibility criteria:
Inclusion Criteria:

          -  ASA physical status I or II , who will be scheduled to undergo unilateral inguinal
             hernia repair

        Exclusion Criteria:

          -  Patients who (i) refuse to participate in the study; (ii) are not able to communicate
             due to alterations in the level of consciousness, or neurologic, or psychiatric
             disease; (iii) present with contraindication to any of the drugs used in the present
             study; (iv) have history of alcohol or drug dependence; (v) are super obese as defined
             by a body mass index (BMI) ≥ 40; and (vi) undergo operation for recurrent,
             strangulated, incarcerated or bilateral hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Effect of Cranial Stimulation and Acupuncture on Pain, Functional Capability and Cerebral Function in Osteoarthritis

Eligibility criteria:
Inclusion Criteria:- Provision of informed consent to participate.

          -  Women with over 18 years old,with chronic pain because of primary osteoarthritis of
             the knee.

          -  Pain stable for at least three months. Score greater than or equal to 3 cm (0 cm = "no
             pain" and "worst possible pain" = 10cm) on Visual Analog Scale (VAS) for pain
             perception at baseline.

          -  No contraindications to electroacupuncture, transcranial direct current stimulation or
             transcranial magnetic stimulation.

        Exclusion Criteria:-Clinically significant or unstable disorder, medical or psychiatric.

          -  Presence of neurological or rheumatic comorbidity.

          -  Pregnancy.

          -  Already having been treated with acupuncture.

          -  Having performed with corticosteroid infiltration in the last six weeks or are using
             this.

          -  Having performed with hyaluronic acid infiltration in the last year.

          -  Previous surgery on the limb to be treated or have surgical program for the next 6
             months.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient's own account: My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Clinical trial: Effects of a PA Intervention for Fatness and Fitness in Adolescents With Intellectual Disability

Eligibility criteria:
Inclusion Criteria:

          -  children with mild ID;

          -  aged 12-18 years old;

          -  overweight or obese;

          -  at least one family member who is able to attend the program with them.

        Exclusion Criteria:

          -  with physical disability;

          -  with a medical predisposition towards obesity (such as genetic syndrome) that could
             interfere with the results of the study;

          -  with contraindications for PA (e.g. severe heart disease).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient's own account: The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Clinical trial: Safety Study for NST-001 and the Neuroject Injection Set to Treat Tinnitus

Eligibility criteria:
Inclusion Criteria:

          -  Patients able to provide voluntary consent.

          -  Severe tinnitus in one ear that began no more than ten years ago.

          -  Ear to be treated must be deaf or have profound hearing loss.

          -  Subjects with cardiac disease or hypertension, must have stable disease for at least 6
             months.

          -  Subject must have intact cochlear nerve on the ear to be treated.

          -  Women of childbearing potential (i.e., not post-menopausal or surgically sterilized)
             must agree to use adequate birth control methods as recommended by the study
             physician.

        Exclusion Criteria:

          -  Current diagnosis of bilateral tinnitus.

          -  Current diagnosis or history of pancreatitis.

          -  Females that are pregnant or lactating.

          -  Use of investigational drugs within the previous 30 days.

          -  History of drug dependency or other substance abuse.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Local Phase IV, Gastroesophageal Reflux Disease (GERD) Sleep Study US

Eligibility criteria:
Inclusion Criteria:

          -  Prior to the run-in period, a history of heartburn or acid regurgitation for 3 months
             or longer or any history of EE;

          -  Prior to the run-in period, nighttime heartburn averaging at least 2 or 3 times per
             week;

          -  Prior to the run-in period, a history of sleep disturbances associated with GERD for 1
             month or more;

        Exclusion Criteria:

          -  Any condition other than GERD that is either the primary cause of, or a significant
             contributor to, the patient's sleep disturbance

          -  Sleep medication (including over-the-counter), antihistamine, benzodiazepine, or
             anti-anxiety medication use that has not been stable (either in dose or regularity)
             for at least 3 months or is not expected to remain stable during the patient's
             participation in the study. Patients on a stable regimen, whose regimen is also
             expected to remain stable throughout the study, are eligible for participation;

          -  Proton Pump Inhibitor (PPI) use within 1 week prior to Screening. The only allowable
             acid modifying rescue medication is GELUSIL® during the run-in period. Only study
             medication and rescue medication (GELUSIL®) is allowed during the treatment period for
             treatment of acid mediated symptoms
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment