Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: The Role of Eicosanoids in the Cardiovascular Actions of Inhaled Nanoparticles

Eligibility criteria:
Inclusion Criteria:

          -  Man or woman between 18 to 40 years of age, inclusive

          -  Judged to be in good health based on medical history, physical examination, vital
             signs and laboratory tests

          -  Body mass index (weight kg/m2) between 18 and 35 kg/m2 (inclusive), and body weight
             between 50 kg and 120 kg (inclusive).

          -  Willing/able to donate blood (and meets the site's blood donor criteria).

          -  No severe or significant medical condition and without intercurrent illness (e.g.
             viral cold or flu, chest infection)

          -  Not taking any regular oral or intravenous medication.

          -  Must be willing to abstain from food and caffeine-containing beverages for at least 12
             hours beforehand, and alcohol for 24 hours beforehand.

        Exclusion Criteria:

          -  Smoked tobacco or related products within 1 year prior to the study

          -  Asthmatic

          -  Occupation with high exposure to air pollution or other inhaled irritant

          -  Severe or significant medical condition

          -  Intercurrent illness (e.g. viral cold or flu, chest infection)

          -  Use of any regular oral or intravenous prescription medication, or non-prescription
             (including aspirin, ibuprofen, paracetamol, vitamins and herbal supplements), and not
             at all in the 7 days prior to the study

          -  Allergy or contraindication to vasodilator drugs (e.g. acetylcholine or sodium
             nitroprusside)

          -  Major or traumatic surgery within 12 weeks of screening

          -  Pregnant or still lactating prior to dose administration (women only)

          -  Given blood in the 3 months prior to the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction