Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: ALGRX 4975 in the Treatment of Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  Acute lateral epicondylitis (LE) of less than 3 months duration (subjects with
             recurrent acute LE may be included).

          -  A screening and baseline severity of pain on resisted wrist dorsiflexion score of
             moderate or greater intensity.

          -  Lidocaine responsive.

          -  A systolic and diastolic blood pressure not greater than 140 and 95 mm Hg,
             respectively.

        Exclusion Criteria:

          -  Any clinically significant form of joint disease, elbow trauma or neuromuscular
             disorder at the elbow, other than acute LE.

          -  Physiotherapy treatment within the preceding 2 weeks, prior to Visit 1.

          -  Any systemic or local corticosteroids within the preceding 3 months, except nasal or
             inhaled steroids at less than or equal to 1000 mcg/day.

          -  A medical condition other than LE that requires the use of a pain medication.

          -  A peripheral sensory or motor neuropathy involving the upper extremities.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient's own account: I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Clinical trial: Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with anterior epistaxis

        Exclusion Criteria:

          -  Unable to consent, do not have a valid telephone number, pregnant women, prisoners,
             cognitively impaired individuals, diagnosis of posterior epistaxis, major trauma,
             bleeding disorder (such as thrombocytopenia or hemophilia), hemodynamically unstable,
             or had a known hypersensitivity to study medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Kinematic-based BoNT-A Injections for Bilateral ET

Eligibility criteria:
Inclusion Criteria:

          -  Consenting male and female participants

          -  Diagnosis of 'definite essential tremor' in accordance with the TRIG criteria
             including: ET individuals diagnosed with upper limb tremor in their motor dominant and
             non-dominant hands

          -  Stable ET medication management for the 3 month duration prior to their enrollment in
             the study

          -  Participants who are botulinum toxin naïve for tremor management

          -  Patients will be screened for pregnancy by the physician

        Exclusion Criteria:

          -  History of stroke

          -  Muscle weakness or any related compartmental muscle syndrome

          -  Smoking

          -  History of ALS or Myasthenia Gravis

          -  Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic
             agonists (e.g. salbutamol)

          -  Persons prescribed zonisamide

          -  History of allergic or side effect reaction to botulinum toxin

          -  Contraindications per the Xeomin® drug monograph

          -  Women reporting that they are pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: National Study of Moderate and Severe Von Willebrand Disease in the Netherlands

Eligibility criteria:
Inclusion Criteria:

          1. haemorrhagic symptoms or a family history of von Willebrand disease

          2. vWF antigen ≤ 30%, lowest measurement counts and/or vWF activity (vWF:RCo of vWF:CB) ≤
             30%, lowest measurement counts and/or FVIII:C ≤ 40 %, lowest measurement counts

          3. being known in a hemophilia treatment center or if only the diagnose is made in a
             hemophilia treatment center this must be done after 1987

        Exclusion Criteria:

          1. Hemophilia A

          2. Carriership of hemophilia A

          3. No informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
             evidenced by medical history, at the time of signing the informed consent.

          2. Must have been on prophylactic hemophilia therapy for at least 12 months prior to
             study entry.

          3. Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
             days (EDs).

          4. No previous documented history of a detectable FVIII inhibitor, <0.6 Bethesda Units
             (BU).

          5. Sexually active participants must agree to use an acceptable method of effective
             contraception. Participants must agree to contraception use for at least 12 weeks
             post-infusion.

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid. Up to 25% of subjects may have
             detectable pre-existing AAV5 capsid antibodies, so long as the titer level is below
             the minimum required dilution (< 20).

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Significant renal dysfunction or liver dysfunction, infection or history of hepatic
             malignancy.

          4. Evidence of any bleeding disorder not related to hemophilia A.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Algorithms for Programming DBS Systems for ET

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of ET

          -  medication-refractory tremor

          -  VIM-DBS implant (unilateral or bilateral)

          -  7T MRI pre-operative scan under Dr. Harel's IRB (institutional review board) protocol
             (#1210M22183)

          -  Post-operative CT scan

        Exclusion Criteria:

          -  history of musculoskeletal disorders that affect movement of the limbs

          -  other significant neurological disorder

          -  prior history of stereotactic neurosurgery (other than VIM-DBS surgery)

          -  pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding State

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of congenital haemophilia A or B with a FVIII:C (Activated
             Coagulation Factor VIIa Clotting activity) or FIX:C (Coagulation Factor IX Clotting
             activity) one stage activity, respectively, at less than 5% of normal (based on
             medical records) plus/minus inhibitors (a positive inhibitor status defined as 0.6
             Bethesda units)

          -  Non-bleeding state (i.e. no clinical manifestation of active bleed) at the time of
             administration of trial product

        Exclusion Criteria:

          -  Known or suspected allergy to trial product or any of its components or to related
             products

          -  Known clinically relevant coagulation disorders or insufficiencies other than
             congenital haemophilia A or B

          -  Platelet count below 50,000 platelets/mcL

          -  Received any haemostatic treatment (e.g. Feiba) within the last 7 days prior to
             administration of trial product, except for activated recombinant human factor VII
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms

Eligibility criteria:
<Women with myoma or adenomyosis>

        Inclusion Criteria:

          1. >20 years old.

          2. Myoma: women with >3 cm uterine myoma

          3. Adenomyosis: women with uterus having several dark area (lacunar areas) in one uterine
             wall or thickening uterine wall

        <The control group>

        Inclusion criteria:

          1. >20 years old.

          2. Women without myoma or adenomyosis

        <Both groups>

        Exclusion Criteria:

          1. The patient has a lower urinary tract infection or acute intestinal inflammation.

          2. Previous surgery for the bladder or urethra.

          3. History of urinary tract stones or tumors.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Understanding Tick-borne Diseases

Eligibility criteria:
Inclusion Criteria for patient with an erythema migrans

          -  Age≥18 years

          -  Erythema migrans

          -  Registered with social security

          -  informed and written consent

        Exclusion Criteria for patient with an erythema migrans

          -  Pregnant women

          -  Immunocompromised patients (undergoing chemotherapy, corticotherapy, or biotherapy)

          -  Chronic inflammatory disease

          -  Systemic disease

        Inclusion Criteria for patient with no-erythema migrans:

          -  Age≥18 years

          -  Confirmed tick bite within the last 6 months prior to the appearance of inflammatory
             joint disease verified via joint imaging (MRI or ultrasound)

          -  and/or cerebrospinal fluid cyto-chemical anomalies (meningitis,albuminocytological
             dissociation)

          -  Registered with social security

          -  informed and written consent

        Exclusion Criteria for patient with no-erythema migrans

          -  Pregnant women

          -  Immunocompromised patients (undergoing chemotherapy, corticotherapy, or biotherapy)

          -  Chronic inflammatory disease

          -  Systemic disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Life Plans Intervention Study

Eligibility criteria:
Inclusion Criteria:

          -  resides in Africa Health Research Institute demographic surveillance area,
             specifically bounded structures to be visited during the last trimester of the
             surveillance in the "Southern PIPSA" area.

          -  member of a household in the AHRI demographic surveillance

          -  18 to 25 years of age

        Exclusion Criteria:

          -  <18, >25 years

          -  not a member of a household under surveillance

          -  not resident in the surveillance area
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment