Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Human Menopausal Gonadotropin (HMG) vs Recombinant Follicle Stimulating Hormone (rFSH) in Gonadotropin Releasing Hormone (GnRH) Antagonist Cycles

Eligibility criteria:
Inclusion Criteria:

          -  women with good physical and mental health

          -  aged 18-37 years

          -  regular menstrual cycles ranging from 25 to 35 days; body mass index (BMI) < 30 kg/m2

          -  normal basal serum FSH (≤ 10 IU/L) and E2 (≤ 75 pg/mL) levels determined on the day 3
             of the cycle previous to COH

          -  no uterine (fibroids, adenomyosis, mullerian malformations), ovarian (endometrioma,
             polycystic ovaries) or adnexa (hydrosalpinx) abnormalities assessed by vaginal
             ultrasound.

        Exclusion Criteria:

          -  patients with a history of recurrent pregnancy loss

          -  any significant systemic disease, endocrine or metabolic disorder

          -  having concomitant medication interfering with the purposes of the study

          -  patients who have received any ovulation induction drug within one month before their
             inclusion in the study.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Prevention of Cystitis.

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
             inclusion criteria may choose to answer the questionnaire in the waiting room of
             general practitioners selected by lot.)

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient's own account: I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Clinical trial: Cough Count Validation

Eligibility criteria:
Inclusion Criteria:

          -  Age 2-80 years.

          -  Patients with significant chronic cough.

          -  Patients in hemodynamic stability. Patient is not in respiratory distress.

          -  Subject or subject's parents/guardians is able to comprehend and give informed consent
             for participation in the study.

        Exclusion Criteria:

          -  Contraindication to the use of the PulmoTrack™ or performing ARM (Acoustic Respiratory
             Monitoring).

          -  Hemodynamic instability and/or SOB.

          -  Concurrent additional major illness.

          -  Concurrent participation in any other study.

          -  Physician objection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Tomographic Findings in COVID-19 and Influenza

Eligibility criteria:
Inclusion Criteria:

          -  Patients with signed informed consent.

          -  Patients with a positive PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency
             department admission.

          -  Patients with lung CT within 24hrs of specimen collection for PCR test.

          -  Patients with complete 30-day follow-up information.

        Exclusion Criteria:

          -  Patients who are unwilling to undergo a lung CT.

          -  Negative PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency department
             admission.

          -  Patients with a tumor or tumor metastasis on the pulmonary CT.

          -  Patients with a previous or de novo autoimmune disease diagnosis.

          -  Patients with a previous or de novo interstitial lung disease.

          -  Pregnancy.

        Elimination Criteria:

          -  Patients with loss of information on the variables of interest.

          -  Patients without 30-day follow-up information.

          -  Patients who chose to withdraw their participation at any time of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient's own account: I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Clinical trial: Platelet-rich-plasma Treating Tennis Elbow

Eligibility criteria:
Inclusion Criteria:

          -  Patient with chronic epicondylitis lateralis who do not react to conservative
             treatment and therefore are send to the orthopedic surgeon

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Traditional Chinese Medicine Formula Liu-Wei-Die-Huang-Wan in the Treatment of Osteoarthritis.

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥20 years old

          -  Written informed consent obtained

          -  Been diagnosed with knee or hip osteoarthritis

          -  The physician interpretation of X-ray identification and joint space narrowing or bone
             spurs confirmed

          -  In randomized trials before entering if used steroids or non-steroid medications
             osteoarthritis stable doses required at least one week

          -  The WOMAC osteoarthritis index of the degree of pain assessment in the past two weeks
             at least> 4ppm pain

        Exclusion Criteria:

          -  Pregnant or breast-feeding women.

          -  Chemotherapy or radiation therapy in cancer patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient's own account: I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Clinical trial: Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hereditary hemochromatosis (HH), homozygous for C282Y, currently treated
             with phlebotomy as maintenance therapy for at least 12 months with ≥ 3 phlebotomies
             per year.

          -  Ferritin level between 50-100 μg/L at start of the inclusion.

          -  Age: 18 years- 60 years and weight > 50 kg.

        Exclusion Criteria:

          -  Patients receiving other therapies such as chelating therapy or forced dietary
             regimen.

          -  Patients younger than 18 years.

          -  HH patients with excessive overweight (BMI > 35).

          -  Patients who are mentally incapacitated.

          -  Women being pregnant or expecting/ planning to become pregnant during the one year
             period of the study.

          -  Patients with a malignancy.

          -  Patients already on PPI treatment.

          -  Patients who experienced side effects of PPI's.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient's own account: I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Clinical trial: Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Verified diagnosis of adrenal insufficiency (Addison's disease)

          -  Stable cortisone acetate replacement therapy

          -  Written informed consent

        Exclusion Criteria:

          -  Malignant disease

          -  Pharmacological treatment with other glucocorticoids

          -  Pregnancy

          -  Current minor disease (ie the flu)

          -  Major disease or accident requiring hospitalization the last three months

          -  Use of grapefruit juice or liquorice the last two weeks before study start

          -  Blood pressure above 150mmHg systolic or 90 mmHg diastolic.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Patiens over 18 years, with primary or secondary Sjogren's Syndrome and xerostomia.

        Exclusion Criteria:

          -  Patiens with cardiac, pulmonary, renal, gastric diseases,

          -  Patients with diabetes, glaucoma, Multipleesclerosis,

          -  Pregnant women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Epi-GERD Study: Epidemiological Evaluation in Patients With Gastro-Esophageal Reflux Disease (GERD)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years

          -  Previous diagnosis of Gastroesophageal Reflux Disease (GERD)

          -  CURRENT treatment with a proton-pump inhibitor (PPI), OR NOT CURRENT treatment with
             some PPI but YES in the last year

        Exclusion Criteria:

          -  Refusal to participate in the study by the patient.

          -  Patients who, in the judgment of the Investigator, do not understand or are not
             willing to adequately answer to the questions.

          -  Mental or psychiatric illness that, in the judgment of the investigator, does not
             allow adequate information to be obtained.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment