Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Yeahhh Baby! Ointment on Hip and/or Knee Pain in Men and Women

Eligibility criteria:
Inclusion Criteria:

          -  Self-reported joint pain with a minimum pain rating of 3/10 for at least the past 30
             days

          -  Recreationally active (2 or more days per week)

          -  Not obese (BMI < 30kg/m2)

        Exclusion Criteria:

          -  Tobacco users/Smokers

          -  Allergic to coconut, walnuts, oak, olives

          -  Currently using anti-inflammatory medicines or dietary supplements (and not willing to
             cease for one-month prior to participation and throughout study)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Investigation of Kritech Efficacy on Subjects Having Functional Discomfort Associated to Joints and Muscles Disorders

Eligibility criteria:
Inclusion Criteria:

          -  Male and female subjects;

          -  >18 years old;

          -  Complaining functional discomfort associated to joints and/or muscles disorders,
             motility disorders and/or initial SMFA score higher or equal to 15 ;

          -  Able to give a written or verbal informed consent,

          -  Affiliated or beneficiary of social security

        Exclusion Criteria:

          -  IMC>30kg/m

          -  Acute or chronic, progressive joint disorders (arthrosis, rheumatoid arthritis, acute
             articular rheumatism) of first or second degree and correlated treatments;

          -  Subjects refusing of giving their written or verbal informed consent

          -  Subjects deprived of freedom following an administrative or judicial decision

          -  Participation to another clinical trial in the last four weeks;

          -  People who already participated to another research that comprises an exclusion period
             still ongoing at the time of inclusion
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: Active Rehabilitation in Osteoporotic Patients

Eligibility criteria:
Inclusion Criteria:

          -  Proven low bone mineral density (t-score < 1.5) plus radius fracture

          -  The radius fracture must not be older than 2 years, and must be healed by start of
             intervention (no plaster cast)

          -  Postmenopausal women above 50 years

          -  Domicile in the Oslo region

        Exclusion Criteria:

          -  Hip fracture or vertebral fracture

          -  History of more than 3 osteoporotic fractures in different parts of the body

          -  Problems/illnesses indicating that active rehabilitation is not indicated

          -  Physical activity (moderate and hard intensity) for more than 4 hours a week

          -  Does not understand Norwegian, written and spoken
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Does Dehydro Epiandrosterone (DHEA) Improve Pregnancy Rate in Women Undergoing IVF/ICSI With Expected Poor Ovarian Response?

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing IVF/ICSI treatment with expected poor ovarian response according to
             the Bologna criteria

        Exclusion Criteria:

          -  Women with BMI >35 Kg/M2

          -  Women with a single ovary

          -  Known allergy to DHEA

          -  Diabetic women on insulin as insulin lowers DHEA levels and might reduce the
             effectiveness of DHEA supplements
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient's own account: I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Clinical trial: A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease

Eligibility criteria:
Inclusion Criteria:

          -  Mild to moderate AD per NIA-AA.

          -  History of cognitive and functional decline over at least 1 year.

          -  MMSE scores between 11 and 24 (inclusive) at baseline.

          -  Brain MRI scan show the highest possibility of AD.

          -  Have a study partner/caregiver.

        Exclusion Criteria:

          -  Diagnosis of a dementia-related central nervous system disease other than AD.

          -  Major structural brain disease as judged by MRI.

          -  A resting heart rate of < 50 beats per minute (bpm) after 5 minutes of rest in sitting
             or supine position.

          -  Major medical illness or unstable medical condition within 6 months of screening.

          -  Concomitant use of AChEIs and/or memantine within 30 days before first MMSE score, and
             during the study.

          -  Inadequate hepatic function.

          -  Inadequate organ and marrow function.

          -  ECG clinically significant abnormalities.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient's own account: I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Clinical trial: Efficacy and Mechanisms of Energy Medicine to Decrease Chronic Knee Pain in Outpatient Settings

Eligibility criteria:
Inclusion Criteria:

          -  Presence of knee pain lasting for at least six months

          -  No radiation of knee pain

          -  No acupuncture treatments in the previous six months

          -  Failure to respond completely to the medications given by their orthopedic or pain
             management specialist

          -  Knee pain on most days (4 out of 7 days of the week) with average self-reported
             severity of 4 or more out of 10 on a numeric rating scale (NRS)

          -  Complaints of morning stiffness lasting less than 30 minutes

          -  Not be in active physical therapy (PT) for the duration of the trial.

          -  Adult patients ≥18 years of age

          -  English speaking

        Exclusion Criteria:

          -  Any concurrent diagnosis of systemic disease

          -  Other concurrent treatments such as massage, Acupcunture, PT or any kind of Energy
             Medicine

          -  Bleeding disorder

          -  Trypanophobia (fear of needles or injections).

          -  Have medical condition that causes difficulty in saliva production/collection (i.e.:
             Sjogren's Syndrome)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Effects of Mineral Water Consumption on Serum Lipid Parameters

Eligibility criteria:
Inclusion Criteria:

          -  Healthy as based on medical history and physical examination

          -  Fasting serum LDL cholesterol > 100 and/or fasting serum triglyceride > 100

          -  Willing to drink mineral water for 12 weeks

          -  Willing not to serve as blood donor during the study

          -  Informed consent signed

        Exclusion Criteria:

          -  Female subjects who are pregnant or nursing a child

          -  Participation in any clinical trial up to 90 days before Day 01 of this study

          -  Renal or hepatic dysfunction

          -  Heart disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study Evaluating rFIX; BeneFIX in Severe Hemophilia B

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia B

          -  Less than 5 years of age

          -  In the investigator's judgment, the patient and/or caregiver will be compliant to
             study procedures

        Exclusion Criteria:

          -  A currently detectable FIX inhibitor. A family history of inhibitors will not exclude
             the patient.

          -  Impaired liver function

          -  Impaired renal function
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 5 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: World Bleeding Disorders Registry Pilot Study

Eligibility criteria:
Inclusion Criteria:

          -  Patients of participating Hemophilia Treatment Centres with Hemophilia A or B.

          -  Ability to provide data in English

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: The Intervention of Multi-vitamin With Minerals to Hyperuricemia

Eligibility criteria:
Inclusion Criteria:

          -  Under the dietary pattern of normal intake of purine, the level of serum uric acid is
             higher than 420μmol/L for male or 360μmol/L for female (not be detected twice at the
             same day).

        Exclusion Criteria:

          -  Gouty arthritis, tophus or gouty nephropathy.

          -  Complications including diabetes, cardiovascular diseases (angina, myocardial
             infarction) and so on.

          -  Taken hypouricemic medicine in the last week before intervention, including
             allopurinol, benzbromarone, probenecid and so on.

          -  Had an operation in the past year.

          -  Malnutrition or severe obesity, BMI<18.5kg/m2 or >30.0 kg/m2.

          -  Mental diseases, tumor, hepatic cirrhosis or other diseases that may interfere with
             the intervention.

          -  Alcohol abuse (>80g/d)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 22 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction