Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Study of Serum Hepcidin Rate Variations During Menstrual Cycle

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged over 18 and under 45 years,

          -  Having given free and informed written consent,

          -  Having regular cycles (defined by a constant interval between periods of 28 to 30
             days),

          -  Having periods for a duration of 4 + / - 1 days

          -  Not using contraception or using oral oestroprogestative contraception.

        Exclusion Criteria:

          -  Contraceptive IUD

          -  Metrorrhagia

          -  Pregnancy,

          -  BMI under 18 kg / m² and above 30 kg / m²,

          -  Presence of at least one of the following abnormalities in serum iron balance :
             Hemoglobin <11.5 g / dl, transferrin saturation under 15% or greater than 50%, serum
             ferritin under 15μg / l or greater than 150 µg / l

          -  Active smoking or quit within the last 6 months

          -  Drinking more than 20 g of alcohol per day ,

          -  Iron supplementation or blood transfusion within 12 months before inclusion

          -  Blood donation within 3 months before inclusion,

          -  Stay in altitude> 1500 m in the previous month before inclusion

          -  Chronic inflammatory disease,

          -  Incapable people over 18 (judicial protection, guardianship) and persons deprived of
             their liberty.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Motivational Interviewing to Increase PrEP Uptake (MI-PrEP)

Eligibility criteria:
Inclusion Criteria:

          -  HIV-negative

          -  Identify as Black and/or African American

          -  Age 18 or older

          -  Cis-gender Female

          -  English speaking

          -  Is capable of completing and fully understanding the informed consent process and the
             study procedures and

          -  Meets the Center for Disease Control's indications for PrEP use (17): (a) any sex with
             opposite sex partners in the past 6 months and (b) not in a monogamous partnership
             with a recently tested HIV-negative partner or (c) any injection of drugs not
             prescribed by a clinician in the past 6 months AND (d) at least one of the following:
             (i) infrequently uses condoms in sex with one/more partners of unknown HIV status (ii)
             in a sexual relationship with an HIV-positive partner or (iii) any sharing of
             injection/drug preparation equipment in past 6 months.

        Exclusion Criteria:

          -  Not capable of completing/fully understanding the consent process and the study
             procedures.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Study to Evaluate Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ASC42 in Healthy Subjects

Eligibility criteria:
Key Inclusion Criteria:

          -  Healthy male and female subjects between 18 to 65 years of age.

          -  Subjects' weight ≥ 50 kg and BMI within the range of 19 - 29 kg/m2.

          -  Physical examination and vital signs are within normal range or slightly abnormal.

        Key Exclusion Criteria:

          -  History or current liver disease, or liver injuries.

          -  A positive HBsAg, HCV Ab and/or HIV Ab.

          -  Platelet count <150,000/mcL

          -  INR> 1.2
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: TAPP Inguinal Hernia Repair With Self-fixating Parietex™ ProGrip™ Mesh

Eligibility criteria:
Inclusion Criteria:

          -  The following diagnosis will be included:

               -  Inguinal hernia: unilateral or bilateral

        All subjects must meet the following inclusion criteria:

          -  ≥18 years of age

          -  Had undergone elective (non-emergent) primary surgical repair of the above diagnosis
             with Parietex ProGrip™ by Laparoscopic Transabdominal preperitoneal inguinal hernia
             repair between September 2008 to March 2010

          -  Post-operative follow-up ≥ 12 months or recurrence which occurs within the 12 months
             post-surgery (If subject has a known incidence of recurrence before the 12 months
             follow up, the subject will be included in the study.)

        Exclusion Criteria:

          -  Subjects who meet any of the following exclusion criteria are not eligible for study
             participation:

               -  Patients with previous laparoscopic Inguinal hernia repair

               -  Emergency procedures

               -  Patients with incarcerated hernias
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Health Related Quality of Life of Youth and Young Adults With Haemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Signed consent form.

          2. Adults, adolescents and children (12-25 years old) with haemophilia A with ABR ≥ 2 on
             at least one-year SHL FVIII prophylaxis.

        Exclusion Criteria:

          1. Patients who have had hypersensitivity reactions to efmoroctocog alfa or other
             constituents of the product.

          2. History of Factor VIII inhibitors.

          3. Patients who have other haemostatic disorders.

          4. Patients participating in interventional studies.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 25 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: Effects of Continuous Combined Hormone Replacement Therapy and Clodronate on Bone Mineral Density (BMD) in Osteoporotic Women

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal

          -  BMD T-score <-2.5sd

        Exclusion Criteria:

          -  None
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 70 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Efficacy and Safety of HuZhen Capsule for Treatment of Patients With Acute Gout

Eligibility criteria:
Inclusion Criteria:

          1. Score is equal to or larger than 40cm on the 0-100cm VAS pain scale.

          2. Acute attack of gout no longer than 2 days.

          3. Participant with acute gout is diagnosed as "damp-heat retention" by Traditional
             Chinese medicine.

          4. Age 18-65 years with informed consent.

        Exclusion Criteria:

          1. Chronic gouty arthritis.

          2. Pseudogout, acute rheumatic fever and suppurative arthritis, traumatic arthritis,
             erysipelas, meander rheumatism and other arthritis.

          3. Anti-inflammatory medication for the treatment of acute gout.

          4. Pregnant or breastfeeding women.

          5. History of severe allergy, including diclofenac sodium.

          6. Serum creatinine is higher than the upper normal limit. ALT or AST is higher than the
             upper normal limit for two times.

          7. Fever ( T>38.5 ℃)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Combined Endoscopic and Laparoscopic Surgery (CELS) for Early Colon Cancer in High Risk Patients

Eligibility criteria:
Inclusion Criteria:

          -  UICC stage 1 colon cancer

          -  ASA score min. 3 and/or WHO PS score min. 1

          -  CELS eligible resection

          -  Biopsy show adenocarcinoma or suspicious lesion

          -  No preop chemo or radiotherapy

          -  Accept inclusion

        Exclusion Criteria:

          -  Hereditary cancer

          -  Rectal cancer

          -  Radiation downstaging
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Efficacy and Safety of ADVATE Standard Prophylaxis to Hemophilia A

Eligibility criteria:
Inclusion Criteria:

          1. Subject has hemophilia A with FVIII≤2 %.

          2. Previously treated patients (PTPs).

          3. Age from 2 to 18 years.

        Exclusion Criteria:

          1. Subject has known hypersensitivity to the active substance or any of the excipients.

          2. Subject has known allergic reaction to mouse or hamster proteins.

          3. Subject has participated in another clinical study involving an investigational
             product (IP) or device within 30 days prior to study enrollment or is scheduled to
             participate in another clinical study involving another FVIII concentrate or device
             during the course of this study.

          4. Subject is planned, or likely to have surgery during the study period.

          5. Subject has end-stage renal failure or evidence of a severe or uncontrolled systemic
             disease as judged by the investigator.

          6. Subject has full-blown Acquired Immuno Deficiency Syndrome (AIDS),determined by
             Cluster Determinant 4+(CD4+) and clinical presentation.

          7. Subject has active hepatic disease (alanine aminotransferase (ALT) and aspartate
             aminotransferase (AST) levels > 5 times the upper limit of normal).

          8. Subject has clinical or laboratory evidence of severe liver impairment including (but
             not limited to) a recent and persistent international normalized ratio (INR)> 1.4,
             and/or the presence of splenomegaly and/or significant spider angioma on physical
             exam, and/or a history of esophageal hemorrhage or documented esophageal varices.

          9. The subject in the opinion of the investigator is unable or unwilling to comply with
             study protocol

         10. Subject is a family member of the investigator or site staff
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient's own account: I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Clinical trial: Study of a Dietary Supplement for Reflux During Sleep

Eligibility criteria:
Inclusion Criteria:

          1. A medical diagnosis of GERD

          2. Awakening with a taste of refluxed stomach acid in the mouth

          3. Heartburn during sleep

          4. Voice hoarseness upon awakening

          5. Antacid use at night

          6. Dry mouth at bedtime or during the night

          7. Experience difficulty chewing, swallowing, and speaking because of dry mouth

        Exclusion Criteria:

          1. Under 18

          2. Prior history of any of these conditions:

               1. coronary artery disease

               2. gallbladder disease

               3. gastric or esophageal cancer

               4. peptic ulcer disease

               5. esophagitis, whether eosinophilic, infectious, or pill based

               6. esophageal motility disorders

          3. A history of thoracic, esophageal, or gastric surgery

          4. No medical examination in the prior year
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment