Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Propranolol and Botulinum Toxin for Essential Vocal Tremor

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of essential voice tremor

          -  Patients who have received or are planning to receive botulinum toxin injections for
             essential voice tremor

          -  Patients who give informed consent to be contacted for research

        Exclusion Criteria:

          -  Patients who are already on a beta blocker

          -  Patients who suffer from hypotension, bradycardia, or otherwise have a medical
             contraindication to beta blocker therapy (eg. moderate to severe bronchial asthma)

        If the patient has received botulinum toxin injections for EVT previously, a three-month
        washout period is necessary before participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient's own account: I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Clinical trial: Normative Database for Pattern Electroretinogram (PERG) and Flash Electroretinogram (FERG)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers age 18 years

          -  older with normal eye exam

        Exclusion Criteria:

          -  spherical refraction outside + 5.0 Diopters and cylinder correction outside + 3.0
             Diopters.

          -  IOP (intraocular pressure) ≥ 22 mm Hg (millimeters of mercury)

          -  history of any type of glaucoma in either eye.

          -  Intraocular surgery in study eye (except non-complicated cataract or refractive
             surgery performed more than 1 year before enrollment).

          -  Best corrected visual acuity worse than 20/40.

          -  Evidence of diabetic retinopathy, diabetic macular edema, or other vitreo-retinal
             disease in either eye.

          -  Evidence of optic nerve, macula and/or retinal nerve fiber layer abnormality in either
             eye.

          -  Evidence of reproducible (false positives, fixation losses and false negatives ≤ 25%
             with no observable testing artifacts).

          -  Standard Automatic Perimetry (SAP) abnormality in either eye, defined as Pattern
             Standard Deviation < 5% level, and/or abnormal Glaucoma Hemifield test result, and/or
             any other pattern of loss which is consistent with a neurologic and/or ocular disease.

          -  Current or recent (within the past 30 days) use of an agent (by any administering
             method) known to affect visual function.

          -  Inability to obtain reliable PERG/FERG (Pattern Electroretinogram/Flash
             Electroretinogram) results.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Clinical Performance Evaluation of KnowNow SARS-CoV-2 Test for the Detection of COVID-19 Antigen

Eligibility criteria:
Inclusion Criteria:

          1. Male or female aged 18 years or over (or age of adult consent in some states within
             the United States).

          2. Suspected COVID-19 infection and / or presenting with at least 1 recognised symptom
             Fever or chills. ie: Cough. Shortness of breath or difficulty breathing, fatigue,
             muscle or body aches, headache, new loss of taste or smell, sore throat

          3. Be willing and able to comply with study procedures.

          4. Be able to give written informed consent.

        Exclusion Criteria:

          1. Inability to give written informed consent.

          2. Vaccinated against SARS-CoV-2

          3. Adults unable to undertake the requirements of the nasopharyngeal or saliva sample
             collection for physical or psychological reasons

          4. Subjects with other significant disease, condition, or at the Clinician's discretion.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Oval-8 Splinting Versus Standardized Treatment With Tee Pee or Forearm Based Thumb Spica Splinting

Eligibility criteria:
Inclusion Criteria:

          -  Carpometacarpal (CMC) osteoarthritis

          -  greater than or equal to 35 degrees of passive thumb interphalangeal (IP) joint
             hyperextension on physical exam

        Exclusion Criteria:

          -  History of hand surgery to affected hand

          -  Prior surgical treatment for thumb carpometacarpal (CMC) osteoarthritis.

          -  Patients with diagnosis of an autoimmune arthritis and post traumatic arthritis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient's own account: I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Clinical trial: Effect of Simethicone on Eustachian Tube Dysfunction

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 to 50 years

          -  Healthy subjects other than current upper respiratory tract infection ("cold")

          -  Jackson Score of 6 on screening

          -  Subject reports symptom onset within 4 days of entry visit

          -  Unilateral or bilateral middle-ear pressure <-50 mmH2O

        Exclusion Criteria:

          -  Otoscopic diagnosis of unilateral or bilateral otitis media

          -  Presence of tympanostomy tubes or tympanic membrane perforations bilaterally

          -  Asthma or any chronic medical disease or condition

          -  Use of an "over the counter" medicine within 24 hours of study or prescription within
             4 weeks of the study day (except birth control)

          -  Use of an experimental drug within 3 months of study

          -  An unusual or allergic reaction to simethicone, food dyes, or preservatives

          -  Pregnancy or breast feeding

          -  Ear surgery other than tympanostomy tube insertion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient's own account: I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Clinical trial: Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder

Eligibility criteria:
Inclusion Criteria:

          -  Meets criteria for RBD as determined by screening PSG's

          -  steady bed partner for completion of RBD questionnaire

        Exclusion Criteria:

          -  Hepatic impairment

          -  RBD associated with narcolepsy

          -  use of fluvoxamine, rifampin, fluconazole or ketoconazole

          -  current alcohol or drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient's own account: I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Clinical trial: Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

Eligibility criteria:
Inclusion Criteria:

          -  Meets criteria established in the locally applicable Directions for Use (DFU) for
             Essential Tremor

          -  Is at least 18 years old

        Exclusion Criteria:

          -  Meets any contraindication in locally applicable Directions for Use
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient's own account: I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Clinical trial: Comparative Study of the Magnetically Guided Capsule Endoscopy Versus High Definition Gastroscopy

Eligibility criteria:
Inclusion Criteria:

          -  Patients with gastric focal lesions (Group A)

          -  Patients with gastric symptoms and indicated for Upper GI endoscopy (Group B)

          -  Age of 18 years to 75 years"

        Exclusion Criteria:

          -  Patients with dysphagia or symptoms of gastric outlet obstruction

          -  Patients with suspected or known intestinal stenoses

          -  Overt GI bleeding

          -  Known large and obstructing tumors of the upper GI tract

          -  Patients after upper GI surgery or abdominal surgery altering GI anatomy

          -  Patients under full anticoagulation

          -  Patient in poor general condition (ASA III/IV)

          -  Patients with claustrophobia

          -  Patients using equipment that may be affected by radio transmission

          -  Patients using equipment that may be affected by magnetic field

          -  Pregnancy or suspected pregnancy "
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: A Direct-to-patient Intervention to Increase Rates of Osteoporosis Care

Eligibility criteria:
Inclusion Criteria:

          -  Self-reported history of fracture

        Exclusion Criteria:

          -  Self-reported current prescription osteoporosis treatment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: A Modified Technique for Laparoscopic Subtotal Hysterectomy

Eligibility criteria:
Inclusion Criteria:

          -  patients aged 20 years old and above with symtomatic uterine myomas or adenomyosis

          -  complete medical record

        Exclusion Criteria:

          -  patients aged below 20 years old

          -  uterine malignancy

          -  incomplete medical record
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Microbiome and Endometrial Receptivity in Obese Infertile Women

Eligibility criteria:
Inclusion Criteria:

          -  Infertile patients undergoing artificial cycle with HRT.

          -  Normal uterus confirmed by ultrasound (absence of uterine pathology such as submucosal
             or intramural myomas> 4 cm that deform cavity, endometrial polyps or Müllerian
             anomalies, or adnexal as communicating hydrosalpinx).

          -  Negative serological tests for HIV, HBV, HCV, RPR

        Exclusion Criteria:

          -  Taking prescribed antibiotics or using IUDs or contraceptives 3 months prior to taking
             the sample. NOTE: Patients who have taken prophylactic antibiotics for ovarian
             puncture may be included at least 1 month before taking the sample.

          -  Age> 45 years

          -  Uncorrected uterine pathology, uncorrected hydrosalpinx

          -  Recurrent miscarriage (≥2 spontaneous abortions) or failure of implantation (transfer
             of 6 embryos in day 3 or 4 blastocysts in a cycle of IVF or donation of oocytes
             without gestation)

          -  Existence of serious or uncontrolled bacterial, fungal or viral infections that, in
             the opinion of the principal investigator, could interfere with the participation of
             the patient in the study or in the evaluation of the results of the study.

          -  Any disease or medical condition that is unstable or could endanger the patient's
             safety and compliance in the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 44 Years

Eligibility (NLI label): Contradiction