Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient's own account: I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Clinical trial: Accuracy of Commercially Available Heart Rate Monitors

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Able and willing to exercise (walk/jog) for a total of fifteen minutes

        Exclusion Criteria:

          -  Health issues that preclude or contraindicate walking and/or jogging, including
             cardiovascular, orthopedic, pulmonary and other conditions

          -  Presence of a cardiac pacemaker

          -  Known cardiovascular disease

          -  Known heart rhythm disorders

          -  Use of Beta-blockers or antiarrhythmic medications

          -  Tattoos around the wrist area
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study

Eligibility criteria:
Inclusion Criteria:

          -  Ability to speak English (fluency)

          -  Willing to provide information for >1 contact person likely to know their whereabouts
             for follow-up.

          -  Documented HIV antibody by ELISA confirmed by Western Blot or current HIV viral load
             greater than 10,000 (in any medical record); or HIV antibody by 4th generation ELISA
             confirmed by a "Multi-Spot" rapid test for discrimination of HIV-1 from HIV-2
             infection and, if necessary in the case of discordant results, nucleic acid testing
             (NAT) for HIV-1; or any other confirmatory pathway approved by the Massachusetts
             Department of Public Health, U.S. Centers for Disease Control and Prevention or BMC
             Center for Infectious Diseases.

          -  Any past 12 month use of illicit drugs, marijuana (not recommended by a healthcare
             provider), or nonmedical use of prescription medications (assessed using the Tobacco,
             Alcohol, Prescription Medication and Other Substances (TAPS) Tool); OR past 12 month
             alcohol use with positive AUDIT-C score (≥3 for females and ≥4 for males)

          -  OR, an existing participant in the Boston ARCH Cohort

        Exclusion Criteria:

          -  Inability to consent or understand interview (determined by trained research
             assistant)

          -  Under age 18

          -  Plans to leave Boston area in <1 year
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis

        Exclusion Criteria:

          -  WOMAC less than 4

          -  Use of braces

          -  Uncontrolled hypertension

          -  Significant psychiatric or psychotic disorder

          -  Not able to attend 75% of sessions

          -  Any other reason that would prevent participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Pharmacokinetics Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A.

Eligibility criteria:
Inclusion Criteria:

          1. Hemophilia A.

          2. FVIII:C <1%. 3）12 and 65 years old.

        4）Has received FVIII treatment and the treatment exposure days ≥100. 5）Has bleeding
        treatment records of at least 3 months before randomization. 6）FVIII inhibitor assay
        results is negative.

        7） Subjects should agree to use an adequate method of contraception during the study.

        8）Understood and Signed an informed consent form. 9）Has not received an treatment of any
        FVIII within 4 days before the first dose.

        10）Non-bleeding state.

        Exclusion Criteria:

          1. Has a history or family history of blood coagulation factor VIII inhibitor.

          2. Has other coagulation dysfunction diseases in addition to hemophilia A.

          3. HIV positive.

          4. Plan to receive surgery during the trial.

          5. Has used immunomodulator within one weeks before the first dose，and less than 7
             half-life periods.

          6. Known to be allergic to experimental drugs or any excipients.

          7. Severe anemia and need blood transfusion.

          8. Serious liver or kidney damage.

          9. Serious heart disease.

         10. Uncontrollable hypertension.

         11. Has participated in other clinical studies within one month before the first dose.

         12. The researchers believe that it is not suitable for participants.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient's own account: I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Clinical trial: Re-exposure Study of Pegloticase Intravenous (i.v.) in Symptomatic Gout Patients

Eligibility criteria:
Inclusion Criteria:

          -  Previous treatment in studies of pegloticase i.v.

          -  Last exposure to pegloticase i.v. greater than one year prior to study entry

          -  Symptomatic gout

          -  Documented hyperuricemic (SUA ≥ 7 mg/dL)

        Exclusion Criteria:

          -  Prior exposure to Elitek® (rasburicase)

          -  Unstable angina

          -  Uncontrolled arrhythmia or hypertension

          -  Non-compensated congestive heart failure

          -  End stage renal disease requiring dialysis

          -  Concomitant use of SUA lowering agents and use of other investigational drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient's own account: I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Clinical trial: Aquamid Reconstruction for Osteoarthritis of the Knee

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  WOMAC pain score >/= 5

          -  Kellgren and Lawrence radiographic scoring >/= 1

          -  Signed informed consent form

        Exclusion Criteria:

          -  Other diseases affecting the joints such as rheumatoid arthritis

          -  Actual or recurrent infections requiring intravenous antibiotic treatment within the
             last 30 days or oral antibiotic treatment within the last 14 days before inclusion

          -  Less than 12 weeks since injection of HA or corticosteroids in study-knee joint before
             treatment

          -  Pregnancy or lactation

          -  Not able to comply with the requirements of the study

          -  Previous alloplasty
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient's own account: I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Clinical trial: Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency Department

Eligibility criteria:
Inclusion Criteria:

          -  patients evaluated in the Emergency Department for loss of consciousness

        Exclusion Criteria:

          -  identification of cause of loss of consciousness after initial evaluation;

          -  loss of consciousness classified as high risk syncope.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Efficacy of the Standard Days Method of Family Planning

Eligibility criteria:
Inclusion Criteria:

          -  Women

          -  Age 18-39

          -  Married or living with stable partner

          -  At least three cycles (four periods) since last birth

          -  Self reported cycles 26-32 days long

          -  Willing to avoid intercourse 12 consecutive days every cycle

          -  Partners willing to collaborate

          -  No known infertility problems

          -  Not at risk for sexually transmitted infections

          -  No contraindications of pregnancy

          -  No use of hormonal contraceptives in three months prior to admission

          -  Desiring to avoid pregnancy for at least one year

        Exclusion Criteria:

          -  Women who have cycles outside of the 26-32 day range

          -  Women/couples not interested in the method

          -  Women who have not yet had 3 regular cycles after childbirth

          -  Women who have used hormonal contraceptives in the previous 3 months

          -  Those women at risk for sexual transmitted infections

          -  Women/couples who cannot manage the fertile days by avoiding intercourse or using a
             barrier method
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: The Efficacy of Different Doses of Acupuncture in Dysmenorrhea

Eligibility criteria:
Inclusion Criteria:

          1. Women within reproductive age (15 to 49 years)

          2. VAS≧4

          3. Women with a history of regular menstrual cycles (28days±7 days)

          4. Self-reported lower abdominal and pelvic, medial anterior thigh pain or low back pain
             associated with the onset of menses and lasting in 72 hours.

        4.Symptoms: dysmenorrhagia, breast pain, dizziness, bloating, cramps, nausea, vomiting,
        diarrhea, headache, fatigue, etc.

        Exclusion Criteria:

          1. Women with irregular menstrual cycles

          2. Women use of an intrauterine contraceptive device (IUCD/IUD)

          3. Women with uncontrolled neurological diseases

          4. Lactation, pregnant women, or those with plans to get pregnant in the coming half year
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 49 Years

Eligibility (NLI label): Entailment