Mathilde/NLI4PR huggingface dataset:
Patient case (clinical description): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient's own account: I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Clinical trial: Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome

Eligibility criteria:
Inclusion Criteria:

          -  patients 15 or more years old

          -  with typical erythema migrans

          -  evaluated between 6/06 and 9/06

          -  evaluated at the Lyme Disease Outpatient Clinic, University Medical Center Ljubljana,
             Slovenia.

        Exclusion Criteria:

          -  history of Lyme disease in the past

          -  pregnancy

          -  lactation

          -  immunocompromising condition

          -  history of a serious adverse reaction to a beta-lactam or tetracycline drug

          -  receiving an antibiotic with known anti-borrelial activity within 10 days

          -  multiple erythema migrans lesions or an extracutaneous manifestation of Lyme disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient's own account: I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Clinical trial: Does Testosterone Improve Function in Hypogonadal Older Men

Eligibility criteria:
Inclusion Criteria:

        age 60-80 yrs serum total testosterone < 300 ng/dL serum bioavailable testosterone < 70
        ng/dL

        Exclusion Criteria:

        unable to provide informed consent history of prostate or breast cancer untreated sleep
        apnea
Male

Subject must be at least 60 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Study to Learn More About the Safety of Drug Jivi Over a Long Period of Time in Previously Treated Patients With Hemophilia A (Bleeding Disorder Resulting From a Lack of FVIII) Who Are Receiving Jivi Regularly at Their Treating Doctors to Prevent Bleeding

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent/assent will be obtained before any study-related activities

          -  PTPs with hemophilia A assigned to Jivi prophylaxis treatment

          -  Negative FVIII inhibitor test before study entry

          -  Decision to initiate treatment with commercially available Jivi has been made by the
             treating physician before and independently from the decision to include the patient
             in this study

        Exclusion Criteria:

          -  Known or suspected contraindications to Jivi or related products

          -  Mental incapacity, unwillingness or other barriers precluding adequate understanding
             or cooperation

          -  Participation in an investigational program with interventions outside of routine
             clinical practice
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient's own account: I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Clinical trial: Effects of Growth Hormone (GH) Treatment on Eating Regulation

Eligibility criteria:
Inclusion Criteria:

          1. Height of at least 2.0 standard deviations below the mean height for chronological age
             and sex according to the 2000 standards from the Centers for Disease Control and
             Prevention (CDC).

          2. Children that have one of the following short stature pathologies:

               1. IGHD or MPHD

               2. ISS

               3. SGA

          3. Proper function of thyroid gland, kidney and liver

          4. Prior to initiating growth hormone treatment

        Exclusion Criteria:

          1. Chronic diseases

          2. Diseases in the digestive system.

          3. Neurological diseases.

          4. Malignant diseases in the past or in the present. Treated with chemotherapy or
             radiation.

          5. Genetic syndromes

          6. Bone diseases

          7. Taking chronic medicine, SSRI type, that effect the appetite and the growth hormone
             signal transduction.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient's own account: I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Clinical trial: Palatability (Energy I Pilot)

Eligibility criteria:
Inclusion Criteria:

          -  You are between the ages of 18 and 50, inclusive, if you are a male or between the
             ages of 18 and 45, inclusive, if you are a female.

          -  your body mass index (BMI) is between 25 and 30 kg/m2, inclusive

          -  For females, if you have regular menstrual periods, with no less than 28 day cycles.

        Exclusion Criteria:

          -  you have a chronic disease that affects body weight, appetite, or metabolism, such as
             diabetes and cardiovascular disease.

          -  You use prescriptions or over-the-counter medications or herbal products that affect
             metabolism or body weight (e.g. weight loss medications such as sibutramine, or
             orlistat).

          -  You have symptoms of depression or excessive dietary restraint.

          -  You have an allergy to one or more of the test foods.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient's own account: I'm a 55-year-old white woman

Clinical trial: A Study Using Imaging Technology to Measure Changes in Bone Structure After Treatment With Teriparatide

Eligibility criteria:
Inclusion Criteria:

          -  postmenopausal (after the "change of life") women with osteoporosis

          -  between the ages of 45-85

          -  have low bone mass as determined by a bone density test

          -  have at least one prior atraumatic vertebral or nonvertebral fracture(with a T-score
             of -2.0 or lower at the lumbar spine, total hip, or femoral neck) or, no prior
             fracture (with a T-score of -3.0 or lower at these same sites)

          -  could have taken up to 5 years total of certain oral osteoporosis medications such as
             alendronate, risedronate, or ibandronate

        Exclusion Criteria:

          -  have conditions that would affect the bone in the region of the wrist or have had a
             previous fracture of either wrist which might affect results of study

          -  have a metal implant or have had a hip replacement in either hip which might affect
             results of study

          -  have an increased risk of osteosarcoma; includes Paget's disease of bone, a previous
             bone tumor, or x-ray treatment to the skeleton

          -  currently have active or suspected diseases that affect the bone, other than
             osteoporosis

          -  have abnormal levels of calcium, parathyroid hormone in blood, or other laboratory
             values
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient's own account: I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Clinical trial: Dental and Periodontal Status of Patients With Sjögren's Syndrome.

Eligibility criteria:
Inclusion Criteria:

          -  Patient with Sjögren Syndrome

          -  Patient > 18 years old

          -  Patient affiliated to a social security system, beneficiary or beneficiary of a right
             other than AME

          -  Patient who speaks and understands French well enough to be able to read and
             understand the study information note.

          -  Patient who does not object to his participation in the study

        Exclusion Criteria:

        - Patient having expressed his opposition to participate in the research
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Eligibility (NLI label): Entailment
Patient case (clinical description): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient's own account: I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Clinical trial: Quality of Life After Laparoscopic Inguinal- Incisional and Umbilical Herniotomy.

Eligibility criteria:
Inclusion Criteria:

          -  elective laparoscopic and open operations for inguinal hernia

          -  elective laparoscopic operation for incisional- and umbilical hernia

          -  primary hernia

          -  uni-bilateral hernias and one or more incisional hernias

        Exclusion Criteria:

          -  expected bad compliance to the study

          -  acute operations

          -  re-operations

          -  secondary operations

          -  primary operation with reoperation within 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Eligibility (NLI label): Entailment
Patient case (clinical description): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient's own account: I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Clinical trial: Treatment of Hemophilia A Patients With FVIII Inhibitors

Eligibility criteria:
Inclusion Criteria:

          -  Male persons with haemophilia A, of any severity, who have a historical inhibitor
             titer ≥ 0.6 BU/mL, including those who have failed previous immune tolerance induction
             (ITI) attempt(s)

          -  Persons undergoing ITI with Nuwiq, octanate, or wilate and/or receiving prophylactic
             therapy with emicizumab, activated prothrombin complex concentrate (aPCC), or
             activated recombinant factor VII (rFVIIa)

          -  Participants or participants' parent(s)/legal guardian(s) must be capable of giving
             signed informed consent and be able to understand the study documents

        Exclusion Criteria:

          -  Participants are excluded from the study if any coagulation disorder other than
             haemophilia A is diagnosed

          -  Partly retrospective patients will be excluded if detailed documentation on treatment,
             all bleeding episodes, inhibitor titers, and FVIII levels is not available for the
             retrospective period
Male
No healthy subjects accepted to join the trial.



Eligibility (NLI label): Contradiction
Patient case (clinical description): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient's own account: I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Clinical trial: Effect of Wearing Personal Protective Equipment (PPE) on CPR Quality in Times of the COVID-19-pandemic

Eligibility criteria:
Inclusion Criteria:

          -  Member of the rescue organization "Croce Bianca"

          -  Aged 18-60

          -  Certified in basic life support (BLS)

          -  No current COVID-19 symptoms, not being tested positive for COVID-19, no COVID-19
             symptoms in the 4 weeks before the tests, no quarantine or unprotected contacts with
             COVID positive patients in the last 4 weeks, body temperature ≤ 37.5°on test days.

          -  Obtained informed consent.

        Exclusion Criteria:

          -  Age <16 or >60 years,

          -  No informed consent

          -  Current COVID-19 symptoms, being tested positive for COVID 19 or symptoms in the 4
             weeks before the tests, quarantine or unprotected contacts with COVID-19 positive
             patients in the last 4 weeks, body temperature ≥ 37.5°on test days.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Eligibility (NLI label): Contradiction
Patient case (clinical description): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient's own account: I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Clinical trial: Predictors of Success of IUI in Unexplained Infertility

Eligibility criteria:
Inclusion Criteria:

          -  These patients had at least 1 tube patent

          -  there were no significant intrauterine or pelvic abnormalities demonstrated on
             pelvic-abdominal ultrasonography, hysteroscopy, and/or laparoscopy

          -  serum follicular stimulating hormone (FSH) level of12 mIU/mL or less

        Exclusion Criteria:

          -  A woman's age of more than 40 years,

          -  ovarian cyst detected in the ultrasound examination

          -  uterine lesions such as submucosal leiomyoma, and a previous diagnosis of moderate to
             severe pelvic endometriosis.

          -  women with body mass index > 35 kg/m2,

          -  PCOS/anovulatory patients

          -  signs of hyperandrogenemia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Eligibility (NLI label): Contradiction