The meaning

Rating: 10/10 (11 July 2002)

Please note that this is my personal interpretation of the movie.
The first half of the movie - before Rita/Camilla (RC) is sucked into the blue box - is how Betty/Diane (BD) wanted her life to go. She came to Hollywood, got a role in a movie, got to knew the everlovely girl RC, which she had a healthy lesbian relationship with. Everything went the way she wanted it to go.
The other half of the movie, is how it really went. BD came to Hollywood - the city of dreams, wealthy successful lives - but got her dreams crushed. She just gets s****y roles in random movies, and RC ditches her, to the advantage of Adam Kesher. She sees no other way but hiring a hitman to kill her. When the job is done, she finds the blue key on her table, and she is driven to death by the old (f***ing scary!) couple. Sort of because she had done one/several of the seven deathsins.
The movie's message is how dreams are broken in Hollywood. On the screen we see happy people, all healthy and successful, but in the reality, most people are tuned down, and end their lives in anger and despite for broken dreams.
The only way to fix it all, is to flush it all away. See you down in Arizona bay.