Has "Existential Angst" truly ever hit you hard?

Rating: 10/10 (30 June 2019)

This film is certainly going to affect different people very differently. My review is going to go down badly with many or most people no doubt. Because I like to avoid spoilers, my reviews tend to concentrate on how they affect me emotionally rather than go into a lot of plot detail. This is, in particular, a "feelings" review. There's a punch line, but it's a little bit of a walk first.
I suffer from a serious genetic disease and am in the middle of cleaning up after an awful family tragedy. I emphatically do not believe that there is a "Big Man in the Sky" (or even, for that matter, a "Flying Spaghetti Monster") looking out for me or any other living thing. There exists no "Grand Plan" that we simply can't comprehend. After all, in my case, I'd have to conclude that God really had it in for me. That's pretty much the definition of a no-win situation.
I have a degree in biology (honestly a minor--just a few classes short of another major--should have just finished it, since I was always at the top of the class), and I continue to read extensively in the field. The world makes sense to me. Unfortunately, it fundamentally isn't nice. (Yes, it's not quite that simple, since human beings are highly social creatures, but I'm talking about the most basic biological level--when we're nice, it's for a reason). As a blatant example of our worst, look no further than our current alpha male President. (Admittedly a very simple evolutionary analysis, but it seems appropriate for a very simple-minded primate who does not appear capable of introspection beyond that of a nonhuman great ape. Frankly, it's an open question whether or not he even actually feels any form of personal pain, although we've got the matter of empathy fully resolved.) "Mother Nature" is a mean old b--ch. (No misogyny intended, only playing off of an ancient, intellectually-juvenile, anthropomorphic interpretation of how the natural world operates.) We don't have to wait for "all to be revealed". Darwin did that quite a while back, and all we've been doing since is tidying up.
If you have my biological problems and my outlook on existence, this movie might really hit you in the gut. If you've ever curled up in a ball contemplating what a brutal and lonely universe we're born into and soon pass out of, you'll totally get this film. On the other hand, if you're confident that there's some great scheme at work behind the scenes that's going to make all of the apparent human and nonhuman suffering ultimately somehow worthwhile, and you have never truly had any significant doubts about that shatter your psyche, then this film might instead seem slow and mostly hit you like water off of a duck.
Who knows, as is currently popular to theorize, maybe I'm (the rest of you don't actually exist) living in some incomprehensibly-deep simulation and somebody or something is pulling strings (writing code?) and there really is some kind of plan. Or, on the other hand, my life is all some kind of cruel or meaningless entertainment. Or, on the third hand (on the internet, nobody knows you're an octopus), maybe it's really as straightforward terrible as it outright appears to be. These are the kinds of thoughts that this film reawakens, if you've ever had them. Obviously these aren't pleasant thoughts, but once you've had them, they never really leave you. That's how this film made me feel.