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Rating: 8/10 (30 May 2012)

The film's only real weakness can be found in the girlfriend and mother characters. Howard and Huston give the roles their best efforts, but both of them are stuck with stereotypical and predictable character arcs. We know exactly how each of them will behave from the moment we meet them, and they offer little to the overall experience.50/50 was inspired by Reiser's own experiences with cancer in his mid twenties, and if there's a message to the movie it's that laughter really is the best medicine. Clichéd? Sure, but that doesn't make it any less true. Finding the humor in any situation is an often overlooked key to survival, and while the film never shies away from the pain, suffering, and depression associated with an experience like this, it stays true to its core belief. The people who make you laugh, in good times and bad, are the people you want and need to keep close.