A cathartic scene makes me want to see the movie again.

Rating: Null/10 (8 October 2011)

One thing not mentioned in any of the other reviews is Howard's portrayal of the girlfriend.
She is a metaphor of the cancer -- a malignancy that has been sucking the life force out of Adam for a long time without his realizing it.
The scenes where she is finally cut out of his life are some of the most satisfying and cathartic moments in film.
If only everyone could cut such toxic people and all the surrounding infected tissue out of their lives with such firmness and finality.
Even though some of his darkest days are still ahead of him, Adam's healing begins with that emotional "surgery." I plan to see the movie again just to enjoy those scenes. Seth Rogan says it all for you.