Blood-C

Blood-C is a horror anime co-produced by studio Production I.G and manga artist group CLAMP. It is the second anime series in the Blood franchise following the 2005--2006 series Blood+. The original 12-episode series aired during 2011, with a movie Blood-C: The Last Dark releasing in Japanese theaters the following year. The anime was subsequently adapted into two manga, a 2011 novelization, a 2015 stage play set between the events of Blood-C and The Last Dark, and two live-action movies.

Question: is blood c a sequel to blood plus
Answer: yes