United States Numbered Highway System

The route numbers and locations are coordinated by the American Association of State Highway and Transportation Officials (AASHTO). The only federal involvement in AASHTO is a nonvoting seat for the United States Department of Transportation. Generally, north-to-south highways are odd-numbered, with lowest numbers in the east, the area of the founding thirteen states of the United States, and highest in the west. Similarly, east-to-west highways are typically even-numbered, with the lowest numbers in the north, where roads were first improved most intensively, and highest in the south. Major north--south routes have numbers ending in ``1'' while major east--west routes have numbers ending in ``0''. Three-digit numbered highways are spur routes of parent highways but are not necessarily connected to their parents. Some divided routes exist to provide two alignments for one route, even though many splits have been eliminated. Special routes, usually posted with a banner, can provide various routes, such as an alternate, bypass or business route, for a U.S. Highway.

Question: do odd interstate routes run primarily north and south
Answer: yes