Perth

Perth is one of the most isolated major cities in the world. The nearest city with a population of more than 100,000 is Adelaide, 2,130 km (1,324 mi) away. Only Honolulu (population 374,660), 3,841 km (2,387 mi) from San Francisco, is more isolated.

Question: is perth western australia the most isolated city in the world
Answer: no