it please the court the pen claims on appeal concern and extremely surprising invention that with meat over twenty years ago no one would have believed that time that you could arrest tumor cells  does not set forth a universal r as a cancer therapy not particularly surprising but perceiving a therapy like radiation with another one that was expected to impede its efficacy that is particularly surprising indeed it is completely lost in the final written decision nowhere to be found that very sentence shows that the boyfriend construction cannot be correct to the board could only reach that claim construction by completely ignoring the prosecution history even if we disclose a site a static a fact and then you get everything else through the combination they did and not and that to turn to that's correct and supported by substantial evidence then would you agree the claim destruction does was not successful in fact after that these men submitted a pretty extensive i d s with references that showed that that wasn't necessarily the case and as a result they had they commended the claim  limitations so it was a critical limitation that was added to the claim that then resulted in allowance and it was error for the board to read the claim as if it wasn't there and i will add that the analysis in the context of obviousness and even though the final written decision said that they were following pens construction they weren't they completely omitted the fact that  during prosecution from the cytotoxic fact they are not the same they are not one and the same going back to the point that you raised about the two different kinds of inherent doesn't doesn't argue that the site is static a fact a limitation is was unexpected there for honeywell is not relevant i think they completely missed the point that there there is a sequence of events and i think it was laid out very well on the where first you need to determine whether the claimed limitations are in the references and then consider whether said whether there was a reasonable expectation of success in the claimed invention i don't see any lights on so i think i'm still within my time i'd like to return to the three buckets of inherent sea air but there it was in the context of the  seventeen and twenty now do you agree that's all of them i think there might have been one more i don't have the list in front of me if i had but they were set forth at the beginning  decision lacks substantial evidence but just i mean if ignoring just means they didn't believe it and so it can't just be ignoring it it has to be there what the weight of the evidence is and while you're while you're answering that how's the how is that decision employing a new legal theory rather than making making factual findings ok let's talk about the heat of an incision and presented at least away it's whether the ords actual determinations on these key points lack substantial evidence and we're looking at we're not looking exclusively at what you think we should have decided because we're not the trier of fact why aren't you concentrating on the evidence cited by the bore against you and why it's such fission rather than repeating your arguments about why you should have prevailed in the first place because i think that the bo that's what you have to do you have to show us that the evidence the board relied on is insufficient to support its findings under the substantial evidence standard not that yours was good enough to reach the contrary result ok will point a censure asking about the evidence i think that it references the combination of the references always already show us that inherently did not  even if you were to take pains construction or found that there was a side of static a fact based primarily on the golfer reference which is prior art and shows an inhibition of growth of the a four thirty what's your response to your friends i think what would be their argument that that's not enough to show and hear and see because it's the record also shows that there's a slight oh i can't keep these  and i'd also like to point out as well that it isn't even part of their construction my friend said that the court misapply pens construction because it didn't deal with whether or not there was a site of toxic effect but i turned the court's attention to page seventy five a start page thirty one of their opening brief in which they specifically state what the debt their definition of cyto static was and it was inhibiting growth by year in end of pharmaceuticals that you can that simply because a property was not known or appreciated by a person of skill in the art and the time of the invention does not mean that it can't be used as part of an inherent c analysis even in the context of obviousness would would that undermine the purpose of an obviousness analysis which looks to the to what a pussy that knew it at at the time the invention was me not in this case because  honeywell the mexican case in which you were talking about forming a refrigerator by combining two different chemicals together and although the properties of that combination were inherent you would have a person to this art and why the term was correct serious if there were correct in saying that nonetheless the claims are invalid in this about that a little bit and that was relying on the goldstein reference and out the end salvi to which showed that you have met all three portions that you arrested cell growth by what was already known in the prior art doesn't take away from the substantial evidence supporting or china action in i'd like to turn then to that the question of the he  evidence as teaching that a four thirty one cells do in fact express p one eighty five and it reach specific lee rejected pens evidence as not addressing the issue so there is very strong factual it's page twenty eight forty two i'm sorry i think i get confused with all the stuff but the problem i think their argument is not the problem but it shows that are outside of our but it doesn't show that the c g twenty five does whatever their finds disrupts dima formation and i believe this is page nine of their patent on a response in footnote they specifically acknowledged so again that's not an issue that was board but again i just want to make the point that this was not a new legal theory this was a factual argument that penn raced for the first time in their patent on a response exact same references the exact same teachings within those references so this is not a situation where there was some new art or some some new legal theory that was put forward for the first time it's exactly the same legal limit the board's ability based on its own legal conclusions based on a fact that has been admitted by the actor and that's exactly  radiation it was not reading a sense of time which is not a surprise because it was not straight or static i'd like to respond to another point that they made about genzyme here i think there's a distinction between new evidence and forward even if they properly raise the obvious this argument based upon selling gold for that they don't show so whatever the heterodyne or issue part of that reference you showed me an octave about it so that something you agree with what it means that the problem is that it does it even though it might it's for us paradigm errors it still doesn't teach using it was illegally improper for the board to dismiss these results as merely inherent after combining references that teach neither the claimed limitations one or the unexpected effect for th respectfully ask that this court reversed the decision of the board and i still have twenty seconds if there's any remaining let me no questions