would you mind going to the third point first because that's the one i think this is has most have to add thank you you're on a very lovely it's recognized in specification and on in the board's opinion page forty next that pulmonary edema was a known life threatening side effect that could occur when patients with left interest or dysfunction were treated with a hill knife or exactly so claimed nine consists of a recommend a recommendation and under the board's construction a based on that recommendation step which involved constructing a doctor to discontinue a known life prevent winning no life threatening side effect of that frequent results and discontinuing the pregnant is the only distinguishing factor over claims that have been held invalid yes you are that's correct and really from our perspective  simply commonsense it's the first principle of medicine first of all do no harm when a life threatening treatment results doctors don't need to be instructed a life threatening side effect results doctors don't need to be instructed that one of the options available to board found a functional relationship between the recommendation to discontinue treatment and the discontinuing of the treatment based on its construction of in accordance with as require a causal link between the two and so for that  treatment based on another known side effect of hell nitric oxide therapy so under k s r when physicians are looking at the options available to them when a known side effect of hell i forgot side therapy a curse one does not teach or suggest the discontinuing step supported by substantial evidence well if there's a life threatening of that so what this patent after the added limitation is if there's some life threatening occurrence based on the dosage then you discontinue i mean i know commonsense has been somewhat of a controversial motion and some of our case thought here with regard to k s r but isn't this really common sense common occurrence i think that there's a functional relationship between that printed matter and the remaining steps of the method for a multitude of reasons but what's a functional relationship well that's a that's a very good question there are i think a functional relationship is one that's making a recommendation doesn't make something happen they don't work together well they do other but i think that there's two interesting examples in the specification that establish that there is a functional relationship other words a causal functional relationship between the information of c one remember play one specifies that the information has to be sufficient to cause a physician who's otherwise considering using the nitric oxide gas to elect not to treat one of more of the units that's sufficient to cause after the protocol was revised they were given the gas with a different set of exclusion criteria and there was an impure called it a benefit in terms of substantial increase in safety the reduction in the number of adverse events that was set forth in the clearing dr rosenthal's operation explaining that empirically the information caused a benefit in terms of reduction in adverse events so i don't think that that alice would it would take the doctor  physician in other words a physician who is otherwise considering giving the drug to a patient with l b d l lacks not to treat them so that's a that's a physical reaction and i think that that's not abstract at all think that's that's you're not you're not claiming a well i don't agree in the sense that if you look at the study you might call it an abstract idea but it resulted in a physical change of more steps in other words the physician stopped treating those patients that have pre safer is to change position behavior with information you can't make the drug itself any safer and sew it up in a real world sense not an abstract sense the way that safety gets implemented in the medical field is by educating  this is necessarily required it says to elect to avoid i think it's i think sufficient cause is both causal and establishes a functional relationship the information has to be sufficient to cause a reaction by the physician and we think that well neither party thought there was or honor in the boarded up to the construction that neither party had proffered and frankly we don't see in any case law more interestingly that the board didn't cite in the affirmative evidence for its construction it dealt with our evidence intrinsic an extra is acceptable in terms of toxicity of a roving term that could be changed just based on the science and the information and that's what was troubling about adding that particular chair upright i think that was the reason i think it's misguided because the construction never changes be that it's pharmaceutical grade i don't think that that's a reasonable construction morpheme you know i can hand somebody morphine it might be pharmaceutical grade or field that doesn't make it pharmaceutical acceptable without information thank you your honor but i heard from my friend an argument about sufficient to cause actually requiring the result to actually take place and claim one is i think a claim construction that i certainly didn't see a must actually require a medical kreider to like to avoid treating it when you look at the language of claim one the steps there are simply obtaining a cylinder computer containing compressed nitric oxide supplying the cylinder and providing information there's no requirement in claim one that actually requires a patient to be treated much less a provider to actually make a decision to treat or not to treat based on the information they need to provide information that is sufficient to cause that result but claim one doesn't actually require that result and until today melodramas never argued that it has now been the other we're going to hear from my friend is that a functional relationship can be shown in jerkily that is you can look at how pattern is actually practiced and see whether information in practice changes the results of one's job changes decisions that are made by physicians this quarter rejected that and in rake out it's six thirty nine f thirty two fifty seven it's a case that we're relied on and we think it's the right guidance for how this quarter and the board should conduct a functional relationship analysis if a functional relationship relates to information does that survive alice if the information has a functional relationship actually causes a physical change in the active steps of other information try to change physical step well i think on the boards construction of claim nine is probably one which is a functional analysis was correct again we think the border area and it's obvious obviousness under claimed nine and we think the board aired its construction of it accordance with it but under the board construction the physician actually has to make a decision to treat or not free as a result of its consideration of information and at least in this court's precedent when you have that link between the information and the accomplishment of physical anyway without it actually affecting you so when you look at the cow case that's another case where excuse me the claims of hard providing information and providing a thoroughly therapeutically effective amount of it or released is and therefore you can come up with some sort of functional relationship even though there's not really one of the claims and this court rejected it actually in for sized in the opinion was nothing in the claims requires that the dosage be adjusted in response to the providing of information so not present claimed any sort of change in what the physician does so how does out a little because our cases and even one of our cases may be king where the case initially went down by the district court on a one  analysis our court changed the analysis i think it was king and went into an obvious and some else and obviously judge laurie and i agree with them there's a feel of a one a one here in a male claim with respect information so how would you recommend that we resolve this sudden traditional printed matter of functional relationship or necessarily because of male and recent supreme court cases we should add in a mental step analysis i think you should resolve it as a form of of the patent and in that regard let me actually turn to my friends discussion from a suitably acceptable because judge where we agree wholeheartedly with the construction that you suggested which is what we think the board that's no obviously we don't believe farm simply examples limiting it all but if it's going to be limiting the work construed as the right way which is simply a physically safe physically nontoxic well is that the conception your friend is making at first everett in the first instance of procedural i'm trying to figure out how pharmaceutical acceptable makes your canister different than any other canister that's out there and what he answered was it's the information that goes with it so motherfucking sayings pharmaceutically supple doesn't mean physically safe it means safe because you are given information that allows it to be safely at present is consistently opposed that primarily by arguing that the preamble is not limiting and not critically here this is not a with respect to claim time where both parties agreed with the construction in the institution decision and then at the hearing the board proposed a new construction notice there was no construction pharmaceutically acceptable  simply found them wanting in that regard we do think this is perhaps most similar to the intellectual ventures to versus erickson case of this court's may seventeenth or sorry mate the decision from the seventeenth so we don't see any procedural issues here with construction  malaprops hasn't attempted to make that link so in our view however even a string from suitably acceptable if you accept the board's view it's not a printed matter limitation that's a physical interaction but there's no functional relationship between that physical limitation and the informational steps except malaprops construction well printed matter becomes informational stuff and there's no functional relationship between that informational stuff and the physical steps of obtaining and supplying what has the support obviously never had to the you know council made a point about not transforming the canister of the cylinder gas and i think that's a misguided point this is not a product claim the printed matter doesn't have to transform the product it's a method claim and so the question is whether the information of printed matter transforms the known method of supplying the gas and we know that it did because prior to the transformation of the printed matter being given to the physicians in the study they were it was criminally giving the drug to patients but whether or not they had function there were a series of adverse events that were substantially higher than expected the printed matter went with the gas with the revision supplied the gas to the same physicians with the printed matter of the said don't