specifically if inhibiting them for a pathway blocks the production of proteins that promote the formation of the new blood vessels that are needed for r c c tumor growth and the district courts conclusion that a skilled artisan would not reasonably expected success combination does not need to be the best option it does not need to be the most preferred option it's simply needs to be a suitable option from which the prior art does not teach a way to think that the judge here was confused and in referring to selection language you may be thinking top well because this is this is exactly like part b t w i were you have a method it's a method of treatment and you know the question is basically whether a skilled artisan would have been motivated to pursue you know to select that method used to practice that method well i don't think there really is i think under cases like par and under cases like there that when there is a finding in this case where there's a limited set of options the district were described as being stubborn or potential treatment options available that when you have a finding that the the repeated statements that the reasonable expectation of success does not need to be a certain one so that's really i mean it if it's a fact you know i think it's fine if it's if the conclusion is that it's a factual error because the district court threw erroneous lee way the bishan will prevent unfair genesis will prevent the formation of cancer is completely irrelevant because this group isn't about preventing formation where's it's about inhibiting the growth of tumors that already exist and so that finding really has no basis and  six of their brief they concede that that's wrong the drug one thousand nine hundred nine actually looked at only one sample of advanced r c c and found that it showed the highest observed levels of have won over expression and then went on and this is a twenty one ninety of the  specifically identify if one over expression as a feature of advanced r c c and these two findings were very important to the district courts ultimate decision if you look at page twenty two of the appendix the district court specifically noted uncertainty concerning the role of ha same direction you have the strong scientific basis for expecting that and i'm sure inhibitor like overall in this one hit tumor growth you have this this phase one clinical data that the art repeatedly characterized as showing impressive anti tumour activity and the quest you know they effectiveness so that's what those studies are targeted at but that's exactly why a reference after reference in this case found this this showed the showings of effectiveness to be particularly surprising and particularly no the results are particularly noteworthy because they came in a phase phase one study in which route in which effects are often limited and so i think not reference after reference i actually found that the fact that these are a phase one study is to be particularly revealing particularly probative but there's no dispute that dr joe estimates expert here used hindsight started with the patent claim and only looked at every element as he never looked at the art as a whole is this your answer to answer to address  of two seemingly inconsistent fact far news the district court here based its conclusion on the fact that westwards expert performed the wrong legal analysis he used hindsight and he never consider the art as a c well that language is less than clear the judge may have been using an obvious to try type standard in that statement but there's no dispute here and judge that that dr cho used hindsight in his motivation analysis and never that oppose it would have been motivated to select of aromas why was the word select use there was a court referring to some kind of lead compound analysis it's possible that that's what the court was referring to but coming back to my point there's dispute here that dr cho did use hindsight in his motivation analysis and that's not permit and for that reason alone we think the district court's motivation conclusion should stand so i'll turn now to reasonable expectation of success there is no evidence here that the district court applied the wrong legal standard in its reasonable expectation of success inclusion in judge repeatedly and consistently articulated the correct standard for obviousness and never suggested it required certainty and regardless of specific language in individual fact findings that doesn't mean the judge applied the wrong standard in his ultimate conclusion that there was no reasonable expectation of success under the clear and convincing evidence stand that district court the district court's ultimate conclusion took into account the flaws and the knowledge gaps in each aspect of westwards case and those rise far above the level of just some general and certainty they include western's reliance on clinical study data that was subject to many undisputed limitations and it was designed to assess safety and not even powered to evaluate a correctly articulated and applied the correct legal standard for reasonable expectations that i'll turn now to westwards allegation that the district court erred in its factual conclusion of no reasonable success and that conclusion was not clear air it was supported by three categories of fact findings relating to the limitations on the phase one diet study data the differences between m tor and the knowledge gaps in westwards molecular biology argument in nitpicking individual fact linings westword ignores the tally of the evidence that supported the district court's conclusion including the admissions of its own expert dr cho and the first category of those factual findings are those that relate to the phase one data for temps or all of this which is a different drug and the claim drug ever will the district court did not air certainly related ever animals right there is some structural similarity between the two ounce and we do need to look at all of the data points and the data points we need to consider including the statements about the promising data that council referred to  the undisputed limitations of those days when statements the district court found that those studies were designed to test the not efficacy and because they weren't even powered to determine i think you see that's undisputed here the district court didn't air refusing to give the data are statements about that data to be elevated weight that westward suggest that we should get those events or that data the studies were also uncontrolled they reported only a small response or no response at all the data here was only preliminary these trials were still ongoing so we only have interim for a luminary data not final data and those results were subject to change in the final study and one of ordinary skill would have also been aware of the fact that there was a dismal success rate for cancer drugs generally and r c c drugs in her to cure the district court here recognize these undisputed limitations and took them all into account and deciding to reduce the weight afforded to the preliminary pharmacological properties that were relevant to inhibiting growth these included differences between the compounds in terms of their half lives finding to f k b twelve as well as the relationship between dose and area under the turn now to the impact of the half life difference we have so dr berger is no artist as expert here testified that all of those differences taken together would lead one of ordinary skill what specifically my question was function of drug distribution bio transformation and elimination and all of these facts would create different as my story understand correctly that half life is the amount of time that the drug will be in the body or i guess it's metabolized that's correct it's essentially the amount of time the drug is in the body before it's metabolized or eliminated or moved to a different that can have an impact on how it impacts the body and the growth of tumor is that with actually yes and yes that's correct half life in combination with cream compound had never been tested as an anti tumour agent in any tumor and i'll turn now to the molecular biology argument which is the third category of facts that support the district court's  suggested the district court found correctly that there were knowledge gaps in this understanding and only a working hypothesis of r c c as molecular biology is evidence did not rise to the level of with respect to the maxwell statement that westward has emphasized that statement was merely a high hypothesis hypothesis that's the language that the district court used in its decision a hypothesis that hip one activation may be linked to angiogenesis in certain tumors and westwood also referenced a statement in maxwell about the genesis but it's explanation for why that statement is not relevant that's a new argument on appeal that was not presented to the district court it also has no expert support dr childer expert never testified that the genesis was not relevant to the claimed invention samples there were advanced r c c samples when only one of the two samples was an advanced sample that errors hardly it doesn't impact the court statement that the art reported mixed results for him one disputed the district court's reliance on cement in this appeal and even if we were to accept westwards interpretation of the song nine hundred ninety nine its own expert testified that zong would have only suggested that additional investigation of his wine may make it an attractive and a novel target for therapeutics so again its own expert is expressing the opinion that additional research is wired begin well let me just try to take these three in turn i realize i don't have a ton of time but as to the data i think the most important thing here is to look at the way the art itself characterized this data and this is over and over again and we had all the two thousand this is a twenty eleven twelve to eleven thirteen the descaler is in would have expected based on the prevalence of advanced r c c in the population that the number of r c c patients in the sample would be small and that is under but in testimony and it's consistent with what the art itself so it twenty thirty one sorry to have it or might work and one might not and that makes sense because they're doing the same thing now does that mean they're going to have exactly the same because they know and doc that joe acknowledged this is this is at ninety seven but testify that a skilled artisan would have expected the inhibitors to understood them to behave sufficiently similarly that they would an artisan would look at this times are almost data and expected to show that similar results in the context of ever on this and again i think the way the are characterized these references the way the experts testified at all points t same way and the binding affinity and and elimination half life issues are really just they don't count or contradict it on the sense that there's no evidence that any of those differences have any clinical facts so if you look at the drugs are potent and sure actually uses this word at twenty eight so the evidence suggests that while these differences may exist that they don't ask they don't have these clinical facts and all the references and all of the testimony suggests that a skilled artisan would have understood these the way to keep any individual reference points is going to be a factual question but again we think that most of these findings if you actually compare what the district court concluded to the art itself and even to the expert testimony that it just doesn't get to where there's very not clear and convincing right that's right absolutes a lot of very it doesn't we think that this is a case where that evidence exists it's actually unusual to have this kind of clinical data and scientific art that all points in the same direction and notably there's no secondary consideration as evidence here there's no teaching away evidence there's nothing pointing the other what but the trial date was not convinced that all the same action well actually i think he was i think what the trial judge said was that some of it there was some grounds for well respectfully no your honor our our obligation is to show that there was a reasonable a skilled artisan would have had a reasonable expectation not necessarily that it would this court has made that abundantly clear that a reasonable expectation is not a success was at least reasonable i see my time is expired i'm happy to answer any more questions by so there really are too vague ideas while working with one of them and what is reasonable and what did the judges think a skill conducting that inquiry rusted on on several sort of conceded mistakes about what they are actually taught so i think that certainly has to be factored in to the bigger picture as you know whether what is our job to determine whether  and again i point the court to thirteen ninety nine to fourteen o two you can actually look at where he sat you never actually disagreed that a skilled artisan would understand these compounds as behaving similarly and that's really the question it doesn't matter whether they are skilled artisan would view the compounds as identical are having the same