member of this panel she was not able to be here today she is listening to the argument she does not plan to ask questions during the argument but she is fully participating in the case ok because for example if you look at can penny for ten dollars to twenty three dollars or four it shows a seventy percent response to the weekly point five milligram you're referring to dee and then some number and you know you'll have to forgive me and the way i think about it is you know certain excerpts that i've read from certain references for example c telling me that they were talking about how you can have ministers you to use seven bi weekly intravenously at point five milligrams per kilogram which as i understand it people seem to agree is roughly forty milligrams so forty milligrams taken every other week and and then i see here an explanation that seems to have a pretty positive outcome i understand that it says for those who did not respond i got up dose but it's not so clear to me that that suggests everyone that that point five milligrams per kilogram did not respond goes yeah but that book that says specifically they were up those because it was a study to determine safety and they wanted to give them the larger dose to measure safety well know but what the purpose of it was to measure safety it wasn't to measure efficacies they weren't of banning the thing because it wasn't efficacious they were changing to twelve weeks because they wanted to measure safety at the higher do what i'm talking about the like to keep as many patients as possible in the study for the long term evaluation of safety patients who did not respond well after point five or one milligram received higher doses i'm reading the study itself forget about the characterizations it says because they up close them because they wanted to conduct a long term about humiliation of safety right wh you i'm sorry i'm not understanding where you're getting that from the sense you showed me had to do with patients who are saving people seem right that is for  argument you've made no i don't you can but you have argued is that the these chart shows superiority for the higher doses and what i'm pointing out to you is that that's true study which takes up to twelve weeks you know over twelve weeks result of moderate response and seventy eight percent of the patients right tenuously twenty milligrams forty milligrams eighty milligrams were all statistically superior over placebo and likewise they were all essentially equivalent in terms just accept for now that substantial evidence supports the idea that can penny also supports that that would be give you a good enough response maybe not as good of a response as one milligram well we already know that taking it by weekly is going to get you a decent result at roughly the same amount as forty milligrams that is to say five milligrams per kil so therefore there is a reasonable basis to go from that point five milligram per kilogram to a fixed forty milligram research every other week race or anything to be she even happen i  patients with point five milligram body when you over twelve weeks result in a moderate yes response and seventy percent of patients is there something wrong with that little better is it possible that what's going on in the latter half of that twelve week cycle with the point five member grams is that those data points are now you have two minutes