and ice and that was construed to cover the molecule that was structural similar rap in mice and it worked there was essentially no meaningful structural limitation as a result this court explaining that mice and there's no reference analogues the definition as precise structural and functional limitations which have to be considered together structural limitation it must have the specific macro cycl character extended the nature of experimentation is that we needed to make use of the invention they put nothing in the record here by contrast when you look at the record here and the declarations  case do you think it's fair to say that your argument would be the same effectively if instead of referring to the what is it five methods of administration in the six or seven of merit but so even if you had didn't have the even a single because you don't really you don't have any evidence that it least human that th idea how to make it happen and nobody in industry ever done it before what is your evidence that he possessed it i know i want to feel we are would be able to do it which i think is the point you just said about a formulator for what what is the evidence  me that when you start up with anachronistically trying ring that is specifically derived from a particular bacteria you given the next person in line a very substantial had started coming up with the that one of the factors that weight on the decision was the fact that the cation itself admitted the infancy of the state of knowledge on my mind and i think it incorrectly lays out that he has to live and die by hi specifically in light of the court's quite construction now focusing on the core stuff in the definition of wrapping life and how many compounds have the characteristics of that definition this is six seven eight six of the record and if i went to a different question and specifically presented with a client construct he started this process where you started the whole discussion half an hour of your own within the twelve hundred dollars limit which is in the limit all the records there's no their own experts say there's anything simple not dictate that and again going back to the cotton reference for example all the analogs we're talking about are changes outside the room or talking about in the less than one hundred dollars range and doctors every single change and make all the difference we know why it hardest tested hundreds to reach a total of three all of the undisputed fact they invented so what is the role of those functional additions how much weight should we attach to them me just backing away from this case and suppose that you have discovered that this compound is effective if there's some way to get it to the  by that is the claim would be construed to come to cover conventional routes routes that people would understand with a particular drug who done nothing exotic such problems by putting a drug in a pill before you swallow it most of the time it was i process but if one of the skill in the art and in fact an expert tells us no no no there's no reason to think that it wouldn't also work here isn't that creating a there was one single if deserve a sentence and investors didn't know one way or the other respectable guesses aren't enough the whole point of the written description requirement if you go to the even though the area of decision is to reward inventors for the difficult work of invention and would be my invention is a full conception of a final and clear plan let me let me make sure i understand that ok with that pessimistic it would depend on how that works and screw if it were to be construed consistent with their invention which is all they knew was that injection for example would work for this large drug for example this were some other drug that was a very small molecule drug that in the literature there was no issues you know getting it through the skin or getting it through that's a different situation but with ra we know that it is incredibly large unstable and virtually insoluble and the state of the art was that for drugs like that you couldn't get it across the skin you couldn't get it across the skin and you have to enable the the skin with this drug and none of them would work and they stopped the program and they said penetration is on life only because of the large insoluble need for this molecule and their expert the best he could do was say well the only thing i could come up with that might work for berman would be if i take the skin off the top layer the skin on all that's not in the  my final thought is that there was no possession here if the service is not enough in light of the state of the art which was essentially nonexistent no one had reached and also as with any drug rec development that's true both as a formulation and as to the project that they had to try to develop these additional drugs and again we have to be very careful when you look at the record here because what you'll find when you look at the refere the reason many of these were discontinued was not that the drugs or the active waiting didn't work but because we couldn't find something better than for all of us i mean that's the difference between commercial development and what's involved in a  of course a company discontinues the program if they can't find something better than the parent drug and that's what the evidence shows here the the bottom line is that because of the factual