instruction which in turn caused the district court to enter summary judgment on infringement and i'd like to address two errors in my time and i'd like to reserve three minutes if i may room as i'm sure the food is where this is a pattern that deals want the list it's a weird line and i don't know where the support in specification comes for that line where you are i believe it comes from several places and what they are is to out to pat and i can give you some examples of the difference between treatment question it is your honor if it has the effect of reducing an f cap and b activity by doing something that is far removed from the signalling pathway that is the entire invention here if i may use an analogy if we were talking about reducing the light in this room as opposed to reducing enough cap of the activity in a set we could turn off the light switch that would be interesting we could go down to the basement of the courthouse and turn off the circuit breaker that that the power to this room that would be extra cellular and it would be part of the signal path where we could blow up the power plant over outside the district that supplies the power to this whole part of the district that would also be extracellular but that would be analogous to what an antibiotic this is not in fact affecting the closed circuit if you will of those of the signalling pathway which is but what right do you want the circuit  respectfully the patent is not limited to only what is inside the cell and that's where the district court made its mistake if i may start with just a few points about why that's wrong as a matter of law i'm a lot more confident about my grammar that i am about my organic chemistry because i was once an english teacher and i would submit your honor and i don't think we could honestly have a fight about this if we do we'll be wrong and i'll be right apprentice usual phrase modifies the term closest to the phrase it does modify the phrase back to earlier in the sentence if i said your hon anywhere i probably might agree but you want a weirdly shaped mine that excludes and i bought it but in captures the infringing devices and i don't understand what's going to patient in this in the claim are you relying on it does too but which limitation in the claim make that a claim limitation as opposed to simply a discussion in the spec right now we turn to claim six shutting down the power plant five miles away could turn off the lights in this room but it has nothing to do with the circulation of electricity in this building which i could affect by turning off the light switch or turning off the circuit breaker i think i think i understand what you're saying so tell me how  effect of preventing the interaction of t n f alpha with the receptor for t n f alpha on the surface it's just like flipping the switch of the circuit breaker it prevents the electricity from getting to the activity to diminish or reduce that's not the case we're talking about here that's what's being distinguished in that state and also you are in charge of that statement it says including particularly again i had to keep going to  talking about english language you know ran under oath nothing for me i'm sorry including your honor doesn't mean excuse doesn't mean that it means including but not limited to it does not mean it does not include the situation in which is an extra cell still be on the grammar and the and the common usage of for example kulu the temperature in a bottle of water by either putting ice in the bottle or putting the bottle and imus either one would cause a cooling of the temperature inside a bottle of water and in the absence of a specific limitation that says it can only be by doing some value in something inside the box the claim would apply to something is being done outside the body and for the reasons i've just tried to describe this plane does not limit itself in fact the only things that are inside the bottle beyond that i ask the court to look at the district court's own claim construction opinion and james principle argument here for limiting the claim to inside the cell is that they say in  tire argument for limited interest in cells is based upon a thousand there is no such limitation remind me again i think you were telling me earlier where the half way that you say i should interpret the n f l happy be mediated interest i understand and thank accomplished by these clients we discussed that in the red briefing pages twenty to twenty one they can't distinguish they came back to their bravery and on page twenty one they say quote antibiotics do i bionics are given to sick people there given to sick people who are already infected with bacteria that are already producing l p s which under their model is already inducing enough capital be active it's not a prophylactic treatment of antibiotics and there's no way to draw a line that says all antibiotics are just before the result yes you're getting rid of the bacteria thereby getting rid of the p s you're not actually getting rid of the l p s that's not in the claims half of b activity in cell which is the only relevant term here wasn't limited so i guess how come that's not a problem here for one case yes it is so broad as to most possibly render it invalid as applied to these claims as well certainly if applied to roads through whiting you hold their feet to the fire and make a move with it here activity that is occurring in the cell why does why does the actor that causes the reduction have to be inside the cell i really don't understand that argument that same thing straight forward twenty one of which are a couple of different reasons first and if care to be activity cells already there for the cells has to relate to the action reduce it and i disagree with mr chester we all time say things work repetition phrases are separated from an action work we did visit the district court i'll do it again cooking dinner in a reduce it the issue is this discussion in connection with the induce and set of limitations and does there need to be prior induction before reduction there needs to be existing in a cabbie activity in order to show reduction and we we doesn't require were that area it wants to impose and just to be clear the reason they want to impose an order is for purposes of their examination it doesn't really deal with the issues here but the point is you can't reduce  the clay language says there's nothing in the specification extracellular anything being part of any pathway and there's there's nothing in the claims about this pathway of the signal transduction after either mr chester is doing something inside the cell to influence the effect of something outside the self that is maintain it isn't isn't limited inside outside distinction it maintains the inside outside distinction and the the pattern talks about the first messenger second messenger system where the first messenger is outside the second messenger is inside and and of captivity is likened to a second messenger which is inside the cell and only inside  to us it's about affecting the south and doing something to the cells response to the stimulus that's what they describe and that it's about and that's that's everywhere it's in the claims it's in the specification it's throughout the reexamination lilly trial and so on that's the way they've characterized this and there really is there isn't a way to construe these claims to reach outside and capture something like campbell it just it it never really touches the  were patent investors wanted to explicitly talk about intervening in the pathway in a particular place they did so and i would ask the court to look at claims thirty two thirty four and thirty five where the exact turning off the light switch which is not what six of eight hundred deal with just one other point i would urge the court in terms of this in cell outside point to look at fourteen sixty one in the record that's part of the prosecution history with respect to clain eighteen which was previously number two hundred one hundred seventy five off and your r s will at that piece of the prosecution history you will see it that the phrase modified by intracellular not reduction and that the patent exempt patent office says that that was merely a formal language change it says that later on the prosecution history so taking out the phrase intracellular activity replacing it with activity in the cells is