laboratory and on practical poultry farmers were required to develop subsequent oxalis commonly known as ask you to the point where it could be produced economically so that older men could use simple practical low cost methods for note that on this fourth day after inoculation with cock city else is the unprotected bird show little change in appetite on the first day however the multiplication of parasites in the cells causes bleeding to start note the bloody droppings in the unprotected group some birds have begun to droop and show the typical ruffling of the feathers some combs are beginning to turn pale carries the first dead bird and another and another active with appetites as keen as ever there are one or two birds that appear listless bleeding continues through the sixth day it's on the fifth and sixth days when most of the deaths occurred some of the droopy birds will be stunted the birds that survive the attack will develop an immunity as proven when tests are made with large doses of all assists at a later date and here's the score at the end of the test based on conservative estimates cost for feed and care were identical for both blocks they only add cost was one dollar and twelve cents for subsequent actual and preventive medication which is sufficient s q to raise one hundred birds to full market weight and here's what resulted from that dollar and twelve cent investment death score only one percent dead in the s q protected flock as against eleven percent dead  unprotected slot in dollars and cents this adds up to a loss of thirty cents per dead bird which covers fifteen cents for the original cost of the chick plus another fifteen cents for normal marketing profit if the bird had survive standing score only one percent started in the s q protected block as against ten percent started in the unprotected slot the additional feed cost of bringing the started birds up to full market weight is estimated at six cents per chick remember this extra profit two dollars and forty two cents is for one hundred birds only in an average broiler plant grazing ten thousand birds the extra profit would be two hundred and forty two dollars more over s q protected birds way more on less feed and have superior market finish hundreds of commercial broiler flocks and millions of birds have been thus protected with no severe outbreaks of single or protected these birds by permitting a mild infection to develop so the birds may acquire an immunity this prevents the damaging effects of uncontrolled has proved to be relatively nontoxic experiments have shown that many times the recommended preventive level has been used without harmful effects with such a large margin of safety there is little danger of overdosing it has been successfully use the year around under a wide variety of climatic conditions the grower who waits until cock city also strikes loses in two ways first in death and second in stunted birds even if a breakthrough does occur due to overcrowding and poor sanitation the cushioning effect of the preventive medication will keep the deaths and starting loss to a very small percentage compared to birds not found the preventive medication when an outbreak of cock city osis occurs in an unprotected block quick action is essential for the disease may spread rapidly between the time of infection and the recognition of the symptoms the first objective is to control the deaths little can be done for severely affected birds but for the rest of the flock the best results can be obtained by using  as possible but why wait until a third day when the infection will have had a four day start s q preventive medication works for you night and day many outbreaks can be satisfactorily controlled by following the two three two three two schedule fill in at the higher levels recommended for the control of outbreaks for three today periods with no treatment during the two intervening periods of three days each as soon as the disease is recognised subsequent actual and should be given as directed on the tag are on the label this two three two three two schedule is not just a group of numbers pulled out of a hat this program has been scientifically developed to break up the cycle of reproduction of the parasite during these twelve of days the birds in many blocks will have developed a satisfactory immunity a bird which has developed an immunity to one type of to permit adequate exposure and reduce the need for medication to a minimum do not change the litter during an outbreak unless absolutely necessary this infected litter is important in developing immunity stir the litter if it has a tendency to cake if water is spilled from the drinking fountain replace the wet litter the experience of a large poultry grower with preventive medication in commercial broiler production showed no severe outbreaks of it should not be considered a cure all there are many complicating diseases which are not controlled by salva can actually or any other cock city as that and there are other poultry diseases which have symptoms similar to and can cause loss of appetite and a reduction of food intake under these conditions the birds getting sulfur can actually in their feed will not be getting the proper concentration for adequate protection from in such cases the concentration in the feed should be increased or the software cannot fill in should be administered in the drinking water since sick birds may drink even when they refuse to feed the occasional appearance of a actually protected flock should be no cause for alarm since this indicates that the birds are building an immunity because it is important to mix the proper concentrations of in the feed uniformly and scientifically the distribution of the drug to poultry growers has been limited to commercial feed manufacturers and veterinary pharmaceutical manufacturers feed manufacturers for example have the equipment and the know how developed through years of experience in blending by them and such is riboflavin in large amounts of feed they are able to mix minute amounts of a drug uniformly with a tonne of feed through a series of progressively larger plans and they can check the thoroughness of the final results with tests required by government regulation the poultry grower can be sure of the proper concentrations as and when needed either in the soluble powders and tablets poultry profits originate with good stock good feed wise management management whose motto is start clean keep clean and these profits can be protected with some to twenty percent broiler is way more on less speed than a hundred birds the flocks maintain greater uniformity and better market quality the drug has no adverse effect on egg production fertility or hatchability there's been no severe outbreak of single or intestinal cox city oh says the raising of hundreds of millions of birds by some of the largest growers in the country it is a fact of the year round under a variety of climatic conditions and it protects the birds while they build immunity the development of subsequent oxalis is an important milestone in the merck resurgent production program devoted not only to more effective disease prevention but also to continuing