and the specification goes into great detail about how the inventors found the binding sites on this very complex enormous trans membrane protein and how they  your specifications suggest that the techniques labeling the mosque and other steps in the claimed are just conventional stuff so well i think you have to look specifically at what specification says and general are massive complex molecules are not like d n a that always works the same way that just as the four base pairs in the same background in the rest of it so how do you determine where an antibody lines of protein that's sort of shown in figure one in the patent and describe later on is different for every protein right you've got to find a specific binding site and then in order to make a protein like musk which is a muscular protein and doesn't exist in can see or more in the blood in order to get it to work in an assay like this you've got to sort of chop it up and make sure that you've got the the right epitope that is that the portion of it to which the antibody specifically binds so that it can be detected and so that you don't interfere with a specific binding and that will be different for every protein i see how that's discussed in detail in your declaration experts declaration where can i day sort of represents the work the inventors did to figure out which fortune of the of the trans membrane proteins are part of the lower the horizontal line there is within the cell and then the i g g regions which make the point that with respect to d n a all these techniques for d n a amplification and so forth were known off the shelf techniques in the mayo case itself doctors have for ever been testing for the site during metaboli the very reason described in those claims and so that was also off the shelf in the same thing was true in the cleveland clinic case with respect to testing for the presence of m p o and that was a decision point in those faces that's why they were decline and they describe a crucial essential that without rich not part of list assaye which didn't exist before you couldn't just you know as in the older cases you know pull a machine off the shelf and well with i say this is i mean it's a method of diagnosing by doing these things i mean you must do these specific things right and in contrast to the earlier cases it's not for example a method of diagnosis by you know to use a language some of the earlier cases like you must use these fragments and you must do it only this way and that's that's all these flames cover and i would also i would further same response to your earlier question that you know methods of diagnosis it's true that the preamble claim is is is cast in those terms but methods of diagnosis are not there are suspect class of invention there's they're still methods and as long as there are concrete steps then the presence of a natural law somewhere within the claim sex at the you know focus and claim seventy or nine and to a lesser extent claim sex so your point is that you don't really know what the status is of claim sex but it's still in play right now that's right and male would self treated claim  in the naturalization ship that was discovered with the patent states about that new assaye that was allegedly discover this is falling and i'm quoting a column three lines thirty three to thirty seven appendix forty four principles but then when they actually the inventors actually went to implement these techniques there are something more to make something work and it and i i understand that's their argument as well first off i point out that it isn't in the claims as that  as the court below found that the complexity described with by their expert for example is not in the claims of the claim simply require these generalized steps and this most specific that they get is the nation that is the most specific step in a rather narrow step if you will just stop but the actual complexity is not in the claims moreover just to be fair that the claims aren't limited to the c described even if you were to somehow read read it in the claims permit the use of full musk so this whole thing of chopping it up into fragments if you will and epa to the claims cover musk apatow or any energetic determent there are so essentially anything that will bind mask so that the complexity is not stated in the claims it's also not fair to characterize the claim to somehow applying to a fragment of muscle but even if that were the case the fact that there's a non difficult to standardize and we have tested an alternative assaye using immuno precipitation i want twenty five miles for this task the purified extracellular domain of mask is i own it using i one twenty specification that these are claims that is or additions if you will that are standard or known per se in the arctic so how does one protect the discovery of the relationship between the they're free to try to get one and if if there's something special about iowa naming or something special that requires human intervention in doing this test they can go get a claim to that and try to artic but what the law prevents as it currently stands is a clay that is directed to a natural law that uses conventional stops to elucidate or observe if you will that natural law discarded materials if if you remember from that case the sira of the mother was typically thrown away and the discovery of that fetal d n a was it was it was a great discovery i did the the patent system has an incentive the fact there's well your honor i beg i disagree with you in the sense that what they have done is discovered the natural ation ship between otto antibodies to mosque and my esteem here products and preempted and claimed a disease that's correct for that and that's the natural association we're talking about and to tie that up with a known test violates the strictures of mayo and the a and p case as well as the sports authorities and cleveland clinic for example as well saying this is medical research product development of fair enough i think that's that's one way of phrasing it just laurie and i think that i'm not going to comment i'm not going to opine about incentives one way or the other whether the incentives in our society exist anough to do medical research versus patents they both have their role which one is better they both have their role i applying a conventional test if conventional technology to this if judge laurie the steps were related to the difficulties they claim which the patent doesn't support but to the extent that the different things to which it's directed like if in fact the claims were directed not only to the natural law but also to something else for example the technique of creating this mosque i don't you claims could certainly have multiple purposes i think in fairness to the lower court judge and the specification i think tells us what these claims are directed to and with hundred sixty one to sixty five which is essentially playing one of the patent and there is provided by a first aspect of the present invention and that first aspect is what ultimately claimed a method of diagnosing neuro of diagnosing the neurotransmission disorder based on the presence of the two antibody to that's what these claims are directed to and that's what the district court so found unless there are further questions i can my client's perspective means it's that issue that it was briefed by us they did not raise arguments in response with respect to plame six so i think the district court was within its power  to say that that claim was invalid as well i think i think also in the first briefing i hope we can provide the appendix a in the first briefing they said and maybe the arguments with respect to thanks for nine applied to claim six as well in the first set of briefing which is where they actually said something about it and then in the second set of reefing they said nothing at all about it so they they responded if you will to make those arguments the first time around and then didn't respond at all the second time around and so i think the district court was proper to to assume that that's all they had  had to say and the order with respect to claim six is proper as well thing because now a whole population of previously on diagnosable patients can be diagnosed and fortunately in the case of m g treated but just because there's a natural law in a claim doesn't mean that the entire claim is directed to the natural method that was freezing and killing the cells a second time but this court found those claims eligible because they applied a natural law same thing in deer right and deer said you can't you can't claim they are any us equation on it's own but if you're using that equation and saw a new and useful method then that doesn't disqualify the claim from eligibility and here inventors discover that correlation and came up with the very first  ust auto antibody detection method no and in order to get there they have to figure out where where the antibodies bound and how to make these fragments in those cases in which where all the methods for doing the so called steps were not only known but in use for those particular reasons already which is why they were trying at this very high level of generality that bordered on an abstraction that is determine whether there's m p o or determine whether there are these five korean metabolites and i'm not going to tell you how because i didn't come up with a method for what i came up with is the correlation you find out and then guess what apply my correlation worth quoting by definition operations even known types of steps on transform subject matter is the stuff of which most processes or methods invention consists applying various known types of procedures to transform its subject matter is not merely applying conventional steps so laws of nature and that's what we have here can't you know as far as manmade goes we are in an p one and not in  because there is nothing natural about what we have synthesised and judge told you asked earlier whether whether our method works only for a for mosque and that's interesting because the court relies in