please the court the fundamental question this case presents is whether the patent trial and appeal board erroneous li found that adding an intentional purpose limitation to an otherwise invalid claim extended sanity's patent monopoly by ten years the three independent legal errors committed by the board when it extended fantasy's patent monopoly are st the board applied the wrong legal standard for obvious cert for public use the board improperly styled to consider evidence that was published after the priority date even though that evidence proved what was written down with specificity before the  foremost the legal standard for obviousness in early two thousand and nineteen this court issued a decision in this case holding that the preamble of the amended claims is limited and requiring that the method be performed with the believe the correct legal standard is the correct legal standard is that in a situation where there is an intentional purpose limitation the question should be whether a person of ordinary skill in the art reasonably with the board said you have undertake these steps with the intent and that you have a reasonable expectation of accomplishing that  yes that reasonable expectation would be that the intentional purpose would be achieved that results would be achieved here demanded claims do not require the result they do not require increasing survival and this this highlights the difference between for instance obviousness what would be required as opposed to invalid that you would necessarily achieve the result of a greater lifespan but that you would reasonably expect that you might do so  don't understand what it is you're finding to be problematic there i mean that's essentially what we see we have said in other cases including the prior sanofi case did we not in the between facts about case and the facts of this case because in that case there was an efficacy requirement the effect the result was actually a claim limitation in the claim language itself decreasing the risk of hospitalization so there was this requirement in the claims of actually achieving a decreased risk of hospitalization that advocacy result was a claim limitation here there is no claim limitation of achieving the result and so this court's decision in intelligent biased systems that results not required by the claims are not relevant a reasonable expectation of success controls success here has to be measured in terms of achieving what is claimed in the patent at issue not in and i'm saying that we have different claim patent and these claims as amended were presented in the st appeal and this court determines the focus of the st appellate decision was whether the preamble was a limitation and this court held that there is a limitation in this preamble it's the intentional purpose limitation so that's one of two differences between the original claims and these amended claims the two differences being the intentional purpose limitation and then a pre treatment regimen and i think the pretreatment regimen is kind of the tail wagging the dog if we focus on not too much the real one the real real question here is focused on the intentional purpose limitation  with this court's guidance but that is a limitation the question then becomes what is required to establish obviousness and it should be the same thing that would be required to prove and for enjoyment and santa see are the let me go back to the santa fe watching case if in there we said that you had you had to have a reasonable expectation of achieving the result but we didn't say that required actually achieving that result right so for instance there if you had a reasonable expectation of a decrease in hospitalization rates for minimum effective amount of the drug it would still infr if in a particular case that didn't happen right maybe that may be the case and i think that case and even the claims in this case highlight the uncertainty surrounding what happens in  patient and an individual patient when you administer the drug it's virtually impossible to tell whether that drug achieved the goal of decreasing the risk of hospitalization because you can't compare the two scenarios where you do and where you administer the drug and that highlights what sanity here is trying to do with the population study results here senna's the is a tendency to say that without the population study results it would be impossible to know to start to reasonably expect an increase in survival and that what's required is phase three clinical trial results since he  that he made a strong distinction between hoping that something would happen and expecting something to happen and in fact kept correcting the questioner during his deposition to make sure that that clarification w and based on this testimony if the hope is not sufficient to reasonably expect that the intentional purpose claim the patient will be met it wouldn't be enough to practice the claim and no doctor could practice it's two sides of the same coin and if a doctor in administrating a drug can only hope that administer not drugs will actually treat the patient effectively well will achieve of the intentional purpose then that physician couldn't that that is exactly what would be required to prove invalidity and this highlights i think the board's misunderstanding guarantee there is no certainty there are no guarantees my nd well the board was very specific that there's no guarantee for any particular patient but after the tropics study there was a reasonable expectation of achieving that for a long survival for the the pate the patient population with this particular illness right yes yes that's right so the holding there is that if i could just finish my thought the whole thing is that the physician has to have this mental state informed by the phase three clinical trial results and only once they have those results and they form the mental state which highlights the idea that there is ineligible subject matter here because the only addition to the claims is this mental a different standard for invalidity infringement and in milans reply brief there are places where milan asserts that increasing survivor that fantasy agrees that increasing survival is not a cl position is that increasing survival is a part of the claims at the limitation and so as part of any infringement analysis it will be santa's fees burden to prove among other things that  nor did they require and in the prior cases is that each cycle of administration so combat attacks or lose is in shoes in in these patients every three weeks so what the claims do not require is that in each cycle a physician makes a specific determination in an individual patient that that patient would not be alive were it not for the combat the tassel treatment this with this prostate cancer that's not a static and doctors say it's as if he has a patient who is living after five cycles about the paxil he says it's safe to say that they're living longer as a result of the therapy milan says in their reply brief that in fact it's so obvious to tell when a patient is having their life along that it's impossible to keep it a secret  are by virtue of the traffic results a position knows that the bag of paxil according to the claim methods increases survival in the patient and so by doing so with with the requisite intent they are practicing increased but they're going to live longer or be able to predict and that's why i use claims are our friend in the way they are do you agree that that with your friend on the other side with respect to his characterization of dr sartorius testimony saying that all he could say was that he hoped that the patients lives would be extended i do not agree with that your honor and i  tropic yes as an investigator in the study he hoped that it would provide increased survival are the results would show increased overall survival but that after the results of the study he then had an expectation he now has an expectation of increasing survival in these patients and therefore can not only now have the requisite intent of increasing survival was really that the board made is that you always only hope with respect to each individual patient that that the that the results that most of the population in the tropics study achieved would be achieved for that particular patient but that doesn't mean that you don't reasonably expect given the tropics study's results that with respect to the broad base of the population that any given one would have that chance any given patient would really have that chance i think there i think your honor there's there is there is area between hope and guarantee and and where where the mind frame of a person of ordinary skill in the art of the considering about the pestle treatment and its potential benefit to a patient where that line solved between hoping and guaranteeing or predicting dramatically from the results of tropic so so having having an expectation which dr starter said he had and i and the board agreed that is prerequisite to having the intent of increasing survival these patients so whether the whether the the  obviousness and now is to as to reasonable expectation of success is rooted in regional expectation of success itself or in the motivation to combine as the bottom line as as the board found one cannot have an intent to increase survival in these patients without that requisite reasonable expectation that it will and that that's particularly true here in the the  apa tex case that you have entirely unpredictable art you have many failures these are patients who are have had failed all therapies including those that paxil which is credited dr sars testimony that prior treatment methods that had shown to have anti cancer activity in these patients ultimately failed to provide any life extension to these patients when studied in phase three one of the things i'd like to address from mr reed is characterizing fantasies physician that it's only after the results of a phase three study that you can render obvious method of treatment claim that's not our position that's what our position is here that there was some minimal information regarding combat attacks of use and potential benefit in light of what i discussed earlier the unpredictability of the  t in this particular case that evidence was not sufficient to provide a reasonable expectation of success which is consistent with the board's findings so in that case yes you could have it could have been a different scenario where you had a phase two study where you had a teaching in the prior art that showed that if you decreased p s a levels in these but those those were not surrogates for increase in survival those are those are very different metrics and that's that that is borne out and highlighted very well in the prior art in those studies where  two or phase one study a particular therapy was found to have anti cancer activity in terms of partial response to the tumor response to p s a reduction but again  evidence supporting such a finding and then the rd bucket evidence opposing such a finding the neutral evidence the board found that the mere existence of the phase three trial was was neutral that it didn't give an indication that that the drug was going to be successful or not as this this court is held before i pop assist does not mean that the outcome is expected believed the traffic study would succeed at the time and said to the extent he resembles a post which of course is not the hypothetical person of ordinary skill in the art the board said that would support a finding of obvious finding that a post that would not have expected the claim treatment method to have resulted in increased survival on the issues of inherent see and  public use an abstract idea as my colleague mr reid used the phrase that applies to both that when you're dealing with a known method issue here the steps of the claims were not a prior art method they were they were not in the prior and the public domain and what what makes that very clear is there is a chart in pages thirty six to thirty nine of my last opening brief the chose where all of the elements are found in the prior art and myla needs no fewer than five different references to find each of the claim limitations and that doesn't even get to of course the intent limitation so this is not an inherent the case and this is not a case where the prior art had a or there was a method in the public domain and there was just an addition of a mental step as  you ok thank you that mystery's you have the last mood thank you very much good feeling i'd like to focus on what mr minion ended on and that is the question of the parents eat and whether it's ok for santa fe to get a patent on the natural result of it public domain math mr mannion suggested that the method was not in the public but it was not part of the prior art when in fact the result of the original and so we have to look at what is different between what was found unpatentable previously and what was added what was added was the intentional purpose limitation and pretreatment regimen t that that one would still not have used the specific combination of treatment elements here well when in deposition yes he was asked about whether he would use all three and he said i think i've used this one but regarding the pretreatment medication regimen the three components two points st there's no evidence that those components increase survival in any respect those are side effect  state doesn't impact what you do next at all it is a purely mental process and the addition of a purely mental process to a prior method is not something that