to focus my argument this morning on three issues that flow directly from the scope of the asserted claims and which require a conclusion that they are invalid as a matter of law and those are our failure to comply with the written description requirement of section one twel the failure to comply with the written district description requirement flows from the contrast between the incredible scope of these claims which in compass any and all means of reducing and if kept to be activity in any and all you carry out a core human cells contrasted with the description of the actual structures of agents that are suitable for that purpose in the specification they really are that instead such agents are prophetically described by step here which is the reduction of an f kappa b activity is not limited in any way in terms of how it is done it can be done by can collegiates it can be done by physical manipulations none of which are described it can be done by i gather he treatment none of which is described to patent it when the trial judge looked at it she said gee it discloses what the result is but it doesn't tell you what the method is and that's exactly the problem there's is it covers absolutely every way you can possibly imagine doing and when you look at the specification for how you're supposed to do that you see a functional description well if you could make this this would do it if you could make that would do it if it had that function and we know from fears lily and amazon that that's not enough if you're relying on function you need some correlation between the function and the structure and there's nothing in the patent there's no correlation given between structure and function because there isn't any indeed when you look at the prosecution history dr baltimore himself submitted a declaration precisely for the purpose of showing how structurally diverse these molecules are that have this function and indeed the expert testimony at trial from both sides was in accord with that as we pointed out in our brief now what happens in that circumstance we have guidance for exactly this kind of process rochester alarms and in the carnegie mellon case all processes involving use of undescribed materials in rochester tells us that simply giving some way by which you might find them is not enough and alonzo says giving away you might find them in giving one concrete example isn't enough to describe it in sleep popularly jesus and carnegie mellon actually provides the rule of decision for this case it's this the genus in compass is substantial variation as this one does since the genus is unlimited that is legally impossible to do now the claim construction there isn't people who are thought with lily at least initially advocating a claim construction that with near zero in op so that the written description would have been one actually addressed the issue now they have a knowledge of human response they contend we don't need to describe agents because we don't use the word agents in the claim and your honors that's by design th claims right before they were allowed acquired the use of agents just like rochester and they have been consistently rejected for lack of written description under this court so that when they were allowed they were glad because  word agents was removed but that problem of the claim that did not exclude agents from the claim it left agents within the claimant left all these other undescribed techniques within the claim and indeed the claim is almost indistinguishable to reduce gene expression and the lizard tech case which we contend is controlling in this issue sites are riley versus morse as an example where the written description is not commensurate in scope with the cleaning and results in a finding  cover every conceivable beings of achieving a result and since the time of o'reilly versus moore's critics they recognize that by definition a necessarily such a claim must in compas things which  was not commensurate in scope with the claim why because the disclosure in such circumstances is necessarily finite and the scope of the claim in such circumstances is limitless and infinite and there must as a matter of l of an example might very well be sufficient and might satisfy the enablement requirement even though the claim might be much broader than the single embodiment disclose well why is there a difference in the after disclosed three ways of making that they had a body and it was some dispute about whether some of them worked but there was no dispute that one of them worked there was a way of making the end of bodies interest by the claim that one moved enable practice of the invention throughout its full scope and under that circumstance you're exactly right your honor one way of making an article is sufficient to support a claim directed to that article but it is not a law claim a family of articles and some of which are enabled and some of which aren't you have the same problem when twelve lack of correspondence between the enabling disclosure but if i kind of remembered of object by dumping them and willing water and the graphic described every kind of go here and subsequently there's a microwave microwave invented which will water and i haven't covered the described anything about the microwave does that mean  not at all in the court has focused on the distinction between predictable technologies and unpredictable technologies it has been the law well it not so much the law but the fact that in relatively simple predictable will or what structural features are required to do it and it's that kind of unpredictability where you have a diverse genus that you have to have a nothing samples throughout the school with a genius law of nature it happened for millennia they may have discovered something about it but it's always been there and it's always the way it's been and the claim that they've got actually preempts all practical applications and principles lie because the applications that are of interest are the ones in human medicine it preempts all uses of that principle in all human cells now it is tantamount to a p characters he didn't print any particular characters he didn't print them any particular way and the fact that people did clean the method are pretty characters and the more restricted that to a particular application so that it wasn't a preemption for that idea then the limitation in this claim of restricting the use to reducing it if can't be to reduce gene expression that's what reducing it capital b does that's the only environment in which it exists and up rates the limitation the claim doesn't prevent it from preempting all practical uses and indeed i think that those court recognized that limiting the preemption to a particular field use doesn't solve the problem so if we believe that the same type of mental facts basically b activity one of thousands of transcription factors that exist in the cells and they disclosed multiple classes of compounds that can be used for this but it's not used in the  because it's just a small piece of d n a and connected with a gene and kept in b instead of binding to a gene will buy into the deep water molecule but even if we accept your argument with respect to the decorum argue all the claims are that they described inhibitors they provided an example of a screen for that they described of the interfering molecules this is more then the disclosure that bill gave in the telephone cases the the paragraph beginning line and then they reference a recent publication by these inventors where they had described partial purification of i can't believe so that was one example of a specific inhibitor which the patent describes by referencing a publication and then the patent brand and you think that that constitutes disclosure of the molecule that's right because you're used to that constitutes written description thing there is the written description for the poor of the molecule that would fall into the inhibitor class could you identify three separate classes which if they are disclosed in the past and this is the sum total of what there is for this there are three different truly pioneering patent and it's clear that they invented something i mean no one even knew what an f kappa be was when this came along and there's no question about that but how given this is the difficulty unfortunately for pioneering that enable you to do that and pointing out additional ways to achieve that just as bill pointed out an additional way to achieve to lessen the having provided only one type of every reaganite you can emulate needs that to written script flung light and antibiotics why don't they do the same thing while antibiotics don't change the way the sil responds to the stimulus what they did was they remove the stimulus instead and that's a critical distinction so in sepsis you may have a better infection you can treat with antibiotics it will take some time until the bacteria go away and the stimulus is removed from the cell in the meantime patients often die this is a completely different way under the influence of the stimulus seemed to me there were some argument it based in the context inherent in anticipation and infringement as to whether the longer responding to it that's what happens in nature what happens in these the claims in soup here are that the cell is being stimulated and you're changing the response but it's not the functioning of this invention that the  that's what that means in that place so again you have a cell which is being stimulated by one or inducing substances outside the cell and you're changing the way this is a response you doing it by one way  do sing and if cattle the activity and the consequence is such that expression of said genes that refers back to the preamble the genes which are to be activated by the extra overfilling and it said it rejected that as well it said it may be that electricity cannot be used at all for the transmission of speech except in the way bill has discovered but that does not make his claim as a regal proposition a full plane go according to our president must be enabled you can then tell me you don't think that that's the situation here but i'm just wondering do you disagree with that statement of our existing president  one way of reducing and it had to be activity that there is no difference in labeling john wayne arms tell me where i'm wrong about this because the difference there is the scope of the claim is the composition so the full scope of the claim is in fact unable because the scope is the composition if not the method of manufacturing if that claim in contrast had covered every method of manufacturing and you would only disclosed one and you would have been able no problem and why isn't that your stimulus that maybe other applications people give us with that that would not for within the scope of these claims here but you claim inhibitor you claim it at least for things aren't covered by your claim right decoys inhibitor what entitled to the this may be a different situation because here claiming a method of producing a certain result and that encompasses virtually any way in which  result is a cheat your honor there are thousands of different transcription factors interfering with any one of them could be a way of changing the way that in which is a response to stimulus the  inventors confined their claims to what they had invented and described namely the way which consists of interfering with end of captivity they provided at least one mode of achieving that they  yes in in order those cases dealt with methods they've literally recited claim elements that were generic and were not and that this visit it's these investors because they were by providing one practical way of achieving what they claimed just as built it had they not being such pioneers they would have had to claim it and the little of generality putting more elements in the claim and that would have triggered a corresponding  respond to the comments with regard to bil changing the way the cell is responding to its environment the way that studies with using it happen so in before application of the invention the cell is receiving the stimulus and is responding in one way it's why if you like in one particular way you not interfered with that mechanism and changed it you've reduced the end of that would be activity and so the still different way specifically by step by changing the way to can critical point written description and enablement are dictated by the scope of the play what's in compass why not the words that are used and it's clear from loser tech loser tech was a case where it absence from the claim of any words describing how the method was to be done that caused it to run afoul of the written description requirement when there was no disclosure in the patent on how to do it your english has nothing to do with what the actual molecules are described in that i do not believe they are and in fact they are not the fact of the matter is our arguments on the one twelve first paragraph are in description maybe we win on that whether they are or not because there's so much else  what about the analogy to the competition claim that he raised about the notion that when you have a composition claim you need only enable one method or certainly i and i understand i stand that we don't agree when you claim a thing you need only disclose a way of making the thing if you claim eight family of things you must disclose a way of making all of the family and when you claim this claim is to a family of methods it is a very clear there is no different standard of enablement for buying your pets there may be a different standard of scope of equivalence that's where the pioneer patent comes into play in terms of the claims go there is no exemption from the disclosure requirements even for and turning to the claims this is been a recurring problem throughout this case which is the area that has repeatedly tried to read limitations into these claims you know in order to avoid inherited  dissipative problem in order to be able to prove infringement it's been a somewhat of a moving target the plain ordinary being of those claims indicates that all you have to do is to reduce and if keppel be an activity whereby the response is altered there's nothing in here that requires in the continuing presence of an inducer they could put that in the claim in their zeal to preempt the future before it had arrived rushing to get these claims out before that time expired this was right because if they'd had to reply that they would lost virtually all the patent term because of the gap provisions they him made these claims as broad as all outdoors and they have picked up the sword and indeed must perish by sort as a result contemplated drugs if you look in column three of the bat you'll see they mention drugs and there is nothing in this path that leads you to determine which drugs do this and which don't which isn't part of the fundamental unfairness here are products i described in patents that were filed before this bad as in the drugs themselves were recognized in described for human use and it's only subsequent tests after the products are fully in development that even reveals the fact that now