this year and the supreme court changed the birds they changed the bird was applied by the district court and actually the burden that reflects the prevailing view in this school what the likely the plaintiffs movement must be deemed likely to prevail or that the are saying substantial question what should the burden therefore be should it be the same burden that exists on trial identical it should be a overcome the showing in that case by the dissent on its affirmative defense and in that case the evidence was in ecuador is according to the supreme court and who had the burden where the patient is live or in a chair with a pump of waiting we understand a method is limited to helping the liver impaired and the one of the just thing that's a different group than the broader group but the method that's the the genus and then you're saying well there's a species where we only administer out of that group to those who are living room why doesn't that like my time in diagram tends to show respectfully first of all if we you're going to claim the geniuses if it was practice end to end on all pages which is the descendants of argument if that were true then every genus would anticipate every single species member in a genius but that is not the lawyer brian reed of the group that they had ministered to was a patient as you point out but that could have been a patient with liver impairment  so i submit that there are two major problems with the runners phillips stuff first that you would be throwing it out the here and you're throwing out i submit the rules that say possibility is not enough it's only a remote possibility that when you practice to go back to your vendor to win when you practice the in that possibility is exactly what is being held over and over again in the not suspicion does that mean that you could really always defeat the outcome in shearing the sharing case it was there was not a nun and that the actual administered and development of the metabolite was the end recognised benefit but if you claimed that as a part of your claim you then have overridden the effect of sharing the anticipatory effect exactly in your last phrase we're selection inventions are quote it is so you still have a big obviousness threshold and i submit in the case that your honor has all the respect that partially put there might be a big obviousness problem here and we have other races that i'm not going to get into about our particular situation obviously well you're going to claim unexpected results and a whole bunch of other secondary considerations like that's not the law and it hasn't been normal and as i said it's been said over and over again your honor started with an attack like a square that argument is called holy narratives by the school you there requires us to dismiss patient populations and targeted therapies which i submit this court should want to encourage that it's where particular groups of people have problems they are a member and if you are not going to throw out the legion of cases the say possibilities like the remote possibility here the one percent possibility here is not enough then completely consistent with and which is completely consistent since all the burden was placed on the defendant to show a substantial question with respect to the the patent and what this court precedents have said is that if a defendant makes that show demonstrates a substantial question then it happened he can no longer rest on the presumption of libby if the patentee wants an injunction he needs to come forward with some evidence to cast doubt on whether or not there is a  people to to continue experiment with drugs that even a drug that has a deficiency like exoplanet dean and find out that for one group of people new use of the drug or don't know this is the same use it just had a different group and so and they claimed it as such so that we know we're just dealing with this minor group now this case and the group of chemical compounds a range of standards are now they've come in and said but we're not going to do that anymore we're not going to give it to everybody now we're only administering it to the liver impair the fact that they want  the species will always fall within the genus that's the definition of a species it's within the genus and so i went to the and in this case but our law says if it's a species genus it's not anticipat people he would say it applies only to a patient your honor i think that the teaching of prior patents a question of fact and it is a patient question of fact in parents it's a question of fact each of those back terminations was made by the district court here