bibtext: @InProceedings{ Xin_Crossconditioned_MICCAI2024,
                   author = { Xing, Zhaohu and Yang, Sicheng and Chen, Sixiang and Ye, Tian and Yang, Yijun and Qin, Jing and Zhu, Lei },
                   title = { { Cross-conditioned Diffusion Model for Medical Image to Image Translation } },
                   booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024},
                   year = {2024},
                   publisher = {Springer Nature Switzerland},
                   volume = { LNCS 15007 },
                   month = {October},
                   pages = { pending },
                }
abstract: Multi-modal magnetic resonance imaging (MRI) provides rich, complementary information for analyzing diseases. 
  However, the practical challenges of acquiring multiple MRI modalities, such as cost, scan time, and safety considerations, often result in incomplete datasets. This affects both the quality of diagnosis and the performance of deep learning models trained on such data. 
  Recent advancements in generative adversarial networks (GANs) and denoising diffusion models have shown promise in natural and medical image-to-image translation tasks. However, the complexity of training GANs and the computational expense associated with diffusion models hinder their development and application in this task. 
  To address these issues, we introduce a Cross-conditioned Diffusion Model (CDM) for medical image-to-image translation. 
  The core idea of CDM is to use the distribution of target modalities as guidance to improve synthesis quality, while achieving higher generation efficiency compared to conventional diffusion models.
  First, we propose a Modality-specific Representation Model (MRM) to model the distribution of target modalities. Then, we design a Modality-decoupled Diffusion Network (MDN) to efficiently and effectively learn the distribution from MRM. Finally, a Cross-conditioned UNet (C-UNet) with a Condition Embedding module is designed to synthesize the target modalities with the source modalities as input and the target distribution for guidance. Extensive experiments conducted on the BraTS2023 and UPenn-GBM benchmark datasets demonstrate the superiority of our method.
title: Cross-conditioned Diffusion Model for Medical Image to Image Translation
authors: Xing, Zhaohu Yang, Sicheng Chen, Sixiang Ye, Tian Yang, Yijun Qin, Jing Zhu, Lei