bibtext: @InProceedings{ Zha_IHCSurv_MICCAI2024,
                   author = { Zhang, Yejia and Chao, Hanqing and Qiu, Zhongwei and Liu, Wenbin and Shen, Yixuan and Sapkota, Nishchal and Gu, Pengfei and Chen, Danny Z. and Lu, Le and Yan, Ke and Jin, Dakai and Bian, Yun and Jiang, Hui },
                   title = { { IHCSurv: Effective Immunohistochemistry Priors for Cancer Survival Analysis in Gigapixel Multi-stain Whole Slide Images } },
                   booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024},
                   year = {2024},
                   publisher = {Springer Nature Switzerland},
                   volume = { LNCS 15004 },
                   month = {October},
                   pages = { pending },
                }
abstract: Recent cancer survival prediction approaches have made great
  strides in analyzing H&E-stained gigapixel whole-slide images. However, methods targeting the immunohistochemistry (IHC) modality remain largely unexplored. We remedy this methodological gap and propose IHCSurv, a new framework that leverages IHC-specific priors to improve downstream survival prediction. We use these priors to guide our model to the most prognostic tissue regions and simultaneously enrich local features. To address drawbacks in recent approaches related to limited spatial context and cross-regional relation modeling, we propose a spatially-constrained spectral clustering algorithm that preserves spatial context alongside an efficient tissue region encoder that facilitates information transfer across tissue regions both within and between images. We evaluate our framework on a multi-stain IHC dataset of pancreatic cancer patients, where IHCSurv markedly outperforms existing state-of-the-art survival prediction methods.
title: IHCSurv: Effective Immunohistochemistry Priors for Cancer Survival Analysis in Gigapixel Multi-stain Whole Slide Images
authors: Zhang, Yejia Chao, Hanqing Qiu, Zhongwei Liu, Wenbin Shen, Yixuan Sapkota, Nishchal Gu, Pengfei Chen, Danny Z. Lu, Le Yan, Ke Jin, Dakai Bian, Yun Jiang, Hui