bibtext: @InProceedings{ Yan_Generalized_MICCAI2024,
                   author = { Yan, Zipei and Liang, Zhile and Liu, Zhengji and Wang, Shuai and Chun, Rachel Ka-Man and Li, Jizhou and Kee, Chea-su and Liang, Dong },
                   title = { { Generalized Robust Fundus Photography-based Vision Loss Estimation for High Myopia } },
                   booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024},
                   year = {2024},
                   publisher = {Springer Nature Switzerland},
                   volume = { LNCS 15001 },
                   month = {October},
                   pages = { pending },
                }
abstract: High myopia significantly increases the risk of irreversible vision loss. Traditional perimetry-based visual field (VF) assessment provides systematic quantification of visual loss but it is subjective and time-consuming. Consequently, machine learning models utilizing fundus photographs to estimate VF have emerged as promising alternatives. However, due to the high variability and the limited availability of VF data, existing VF estimation models fail to generalize well, particularly when facing out-of-distribution data across diverse centers and populations. To tackle this challenge, we propose a novel, parameter-efficient framework to enhance the generalized robustness of VF estimation on both in- and out-of-distribution data. Specifically, we design a Refinement-by-Denoising (RED) module for feature refinement and adaptation from pretrained vision models, aiming to learn high-entropy feature representations and to mitigate the domain gap effectively and efficiently. Through independent validation on two distinct real-world datasets from separate centers, our method significantly outperforms existing approaches in RMSE, MAE and correlation coefficient for both internal and external validation. Our proposed framework benefits both in- and out-of-distribution VF estimation, offering significant clinical implications and potential utility in real-world ophthalmic practices.
title: Generalized Robust Fundus Photography-based Vision Loss Estimation for High Myopia
authors: Yan, Zipei Liang, Zhile Liu, Zhengji Wang, Shuai Chun, Rachel Ka-Man Li, Jizhou Kee, Chea-su Liang, Dong