bibtext: @InProceedings{ Sør_Spatiotemporal_MICCAI2024,
                   author = { Sørensen, Kristine and Diez, Paula and Margeta, Jan and El Youssef, Yasmin and Pham, Michael and Pedersen, Jonas Jalili and Kühl, Tobias and de Backer, Ole and Kofoed, Klaus and Camara, Oscar and Paulsen, Rasmus },
                   title = { { Spatio-temporal neural distance fields for conditional generative modeling of the heart } },
                   booktitle = {Medical Image Computing and Computer Assisted Intervention -- MICCAI 2024},
                   year = {2024},
                   publisher = {Springer Nature Switzerland},
                   volume = { LNCS 15003 },
                   month = {October},
                   pages = { pending },
                }
abstract: The rhythmic pumping motion of the heart stands as a cornerstone in life, as it circulates blood to the entire human body through a series of carefully timed contractions of the individual chambers. Changes in the size, shape and movement of the chambers can be important markers for cardiac disease and modeling this in relation to clinical demography or disease is therefore of interest. Existing methods for spatio-temporal modeling of the human heart require shape correspondence over time or suffer from large memory requirements, making it difficult to use for complex anatomies. We introduce a novel conditional generative model, where the shape and movement is modeled implicitly in the form of a spatio-temporal neural distance field and conditioned on clinical demography. The model is based on an auto-decoder architecture and aims to disentangle the individual variations from that related to the clinical demography. It is tested on the left atrium (including the left atrial appendage), where it outperforms current state-of-the-art methods for anatomical sequence completion and generates synthetic sequences that realistically mimics the shape and motion of the real left atrium. In practice, this means we can infer functional measurements from a static image, generate synthetic populations with specified demography or disease and investigate how non-imaging clinical data effect the shape and motion of cardiac anatomies.
title: Spatio-temporal neural distance fields for conditional generative modeling of the heart
authors: Sørensen, Kristine Diez, Paula Margeta, Jan El Youssef, Yasmin Pham, Michael Pedersen, Jonas Jalili Kühl, Tobias de Backer, Ole Kofoed, Klaus Camara, Oscar Paulsen, Rasmus