User: What is the difference between a Fender Strat and Gibson Les Paul guitar?
Assistant: The main difference is the pickups used in each of these guitars. Fender Strat has single coil pickups which give it a brighter sound while the Gibson Les Paul uses humbucker pickups which give it a more thicker, deeper sound. Eric Clapton mostly uses Strats while Slash of Guns and Roses fame uses a les paul.