User: Based on the text, please give me a brief summary of the history of the DTES neighbourhood in Vancouver
Assistant: The DTES has transformed from the focal point of Vancouver’s cultural and commercial life at the start of the 20th Century to an impoverished neighbourhood with many socio-economic problems by the 1980s. Since the 1990s, the DTES has been home to a public health emergency due to drug overdoses, HIV infection, a housing crisis, and mental health problems.