premise: It also became a prime base for missionary activity, with its succession of devout followers of different faiths the Franciscans, Augustinians, Dominicans, and the Jesuits which held them in line along with a rigorous Inquisition most notably led by Francis Xavier, who came to Goa in the year 1542.
hypothesis: Francis Xavier came to Goa in 1542 in order to lead an Inquisition.