premise: In foreign affairs, after he had crushed the Duke of Milan's army at Marignano and formed a showy alliance with Henry VIII of England, Francois I's European ambitions were halted by the German Emperor Charles V. Francois even suffered the indignity of a year's imprisonment in Madrid, following a resounding defeat at Pavia in 1525.
hypothesis: After serving time in prison, Francois came back into power.