Input: Relationship: 'be publish in', Argument/Subject 1: 'journal', Argument/Subject 2: 'january'

Answer: In the January 4 , 2007 edition of the New England Journal of Medicine , a paper was published documenting a British study of over 11,000 Parkinson 's Disease patients , which found that two commonly used Parkinson 's drugs derived from ergot , Pergolide and Cabergoline , may increase the risk of leaky heart valves by up to 700 % .