LiteFold/PDB huggingface dataset:
PDB entry 4hxd: Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases
Classification: hydrolase/viral protein
Source organism: Dugbe virus (isolate ArD44313); Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.85 Å
Deposited: 2012-11-09
Authors: Capodagli, G.C., Pegan, S.D.
PDB entry 4hxe: Pyrococcus horikoshii acylaminoacyl peptidase (uncomplexed)
Classification: HYDROLASE
Source organism: Pyrococcus horikoshii
Experimental method: X-RAY DIFFRACTION
Resolution: 1.91 Å
Deposited: 2012-11-09
Authors: Tichy-Racs, E., Hornung, B., Radi, K., Menyhard, D.K., Kiss-Szeman, A., Szeltner, Z., Domokos, K., Szamosi, I., Naray-Szabo, G., Polgar, L., Harmat, V.
PDB entry 4hxf: Acylaminoacyl peptidase in complex with Z-Gly-Gly-Phe-chloromethyl ketone
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Pyrococcus horikoshii
Experimental method: X-RAY DIFFRACTION
Resolution: 1.601 Å
Deposited: 2012-11-09
Authors: Kiss-Szeman, A., Menyhard, D.K., Tichy-Racs, E., Hornung, B., Radi, K., Szeltner, Z., Domokos, K., Szamosi, I., Naray-Szabo, G., Polgar, L., Harmat, V.
PDB entry 4hxg: Pyrococcus horikoshii acylaminoacyl peptidase (orthorhombic crystal form)
Classification: HYDROLASE
Source organism: Pyrococcus horikoshii
Experimental method: X-RAY DIFFRACTION
Resolution: 2.7 Å
Deposited: 2012-11-09
Authors: Kiss-Szeman, A., Menyhard, D.K., Tichy-Racs, E., Hornung, B., Radi, K., Szeltner, Z., Domokos, K., Szamosi, I., Naray-Szabo, G., Polgar, L., Harmat, V.
PDB entry 4hxi: Crystal structure of KLHL3/Cul3 complex
Classification: PROTEIN BINDING
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 3.513 Å
Deposited: 2012-11-10
Authors: Ji, A.X., Prive, G.G.
PDB entry 4hxj: Crystal structure of SH3:RGT complex
Classification: BLOOD CLOTTING, SIGNALING PROTEIN
Source organism: Homo sapiens; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 2012-11-11
Authors: Xiao, R., Meng, G.
PDB entry 4hxk: Brd4 Bromodomain 1 complex with 6,7-DIHYDROTHIENO[3,2-C]PYRIDIN-5(4H)-YL(1H-IMIDAZOL-1-YL)METHANONE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.61 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxl: Brd4 Bromodomain 1 complex with 3-CYCLOHEXYL-N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}PROPANAMIDE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.52 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxm: Brd4 Bromodomain 1 complex with N-{3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)-5-[(THIOPHEN-2-YLSULFONYL)AMINO]PHENYL}BUTANAMIDE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxn: Brd4 Bromodomain 1 complex with 4-(2-FLUOROPHENYL)-1,3-THIAZOL-2(3H)-ONE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.49 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxo: Brd4 Bromodomain 1 complex with 3-{[(3-METHYL-1,2-OXAZOL-5-YL)METHYL]SULFANYL}[1,2,4]TRIAZOLO[4,3-A]PYRIDINE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.76 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxp: Brd4 Bromodomain 1 complex with 4-(2-OXO-1,3-OXAZOLIDIN-3-YL)BENZAMIDE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.73 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxq: Crystal structure of human Arginase-1 complexed with inhibitor 14
Classification: Hydrolase/Hydrolase Inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.45 Å
Deposited: 2012-11-12
Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett, P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.
PDB entry 4hxr: Brd4 Bromodomain 1 complex with N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]THIOPHENE-2-SULFONAMIDE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.53 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxs: Brd4 Bromodomain 1 complex with N-[3-(2-OXO-2,3-DIHYDRO-1,3-THIAZOL-4-YL)PHENYL]-1-PHENYLMETHANESULFONAMIDE inhibitor
Classification: PROTEIN BINDING/INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.43 Å
Deposited: 2012-11-12
Authors: Chen, T.T., Cao, D.Y., Chen, W.Y., Xiong, B., Shen, J.K., Xu, Y.C.
PDB entry 4hxt: Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR329
Classification: DE NOVO PROTEIN
Source organism: artificial gene
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95 Å
Deposited: 2012-11-12
Authors: Vorobiev, S., Su, M., Parmeggiani, F., Seetharaman, J., Huang, P.-S., Maglaqui, M., Xiao, X., Lee, D., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
PDB entry 4hxv: Crystal structure of 3'(2'),5'-bisphosphate nucleotidase1 from Entamoeba histolytica in complex with AMP and metal ions
Classification: HYDROLASE
Source organism: Entamoeba histolytica
Experimental method: X-RAY DIFFRACTION
Resolution: 2.6 Å
Deposited: 2012-11-12
Authors: Tarique, K.F., Abdul Rehman, S.A., Gourinath, S.
PDB entry 4hxw: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: Isomerase/Isomerase inhibitor
Source organism: Enterococcus faecalis
Experimental method: X-RAY DIFFRACTION
Resolution: 1.69 Å
Deposited: 2012-11-12
Authors: Bensen, D.C., Trzoss, M., Tari, L.W.
PDB entry 4hxx: Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.09 Å
Deposited: 2012-11-12
Authors: Gabelli, S.B., Zhang, F., Liu, J., Amzel, L.M.
PDB entry 4hxy: PlmKR1-Ketoreductase from the first module of phoslactomycin biosynthesis in Streptomyces sp. HK803
Classification: OXIDOREDUCTASE
Source organism: Streptomyces sp. HK803
Experimental method: X-RAY DIFFRACTION
Resolution: 1.68 Å
Deposited: 2012-11-12
Authors: Whicher, J.R., Smith, J.L.
PDB entry 4hxz: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: isomerase/isomerase inhibitor
Source organism: Francisella tularensis subsp. holarctica
Experimental method: X-RAY DIFFRACTION
Resolution: 2.7 Å
Deposited: 2012-11-12
Authors: Bensen, D.C., Creighton, C.J., Kwan, B., Tari, L.W.
PDB entry 4hy0: Crystal structure of XIAP BIR3 with T3256336
Classification: LIGASE/LIGASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.84 Å
Deposited: 2012-11-12
Authors: Snell, G.S., Dougan, D.R.
PDB entry 4hy1: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: isomerase/isomerase inhibitor
Source organism: Francisella tularensis subsp. holarctica
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9 Å
Deposited: 2012-11-12
Authors: Bensen, D.C., Creighton, C.J., Kwan, B., Tari, L.W.
PDB entry 4hy2: Crystal structure of Plk1 Polo-box domain in complex with PL-42
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Homo sapiens; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 2012-11-12
Authors: Lee, W.C., Song, J.H., Kim, H.Y.
PDB entry 4hy3: Crystal structure of a phosphoglycerate oxidoreductase from rhizobium etli
Classification: OXIDOREDUCTASE
Source organism: Rhizobium etli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.8 Å
Deposited: 2012-11-12
Authors: Kumaran, D., Chamala, S., Evans, B., Foti, R., Gizzi, A., Hillerich, B., Kar, A., Lafleur, J., Seidel, R., Villigas, G., Zencheck, W., Almo, S.C., Swaminathan, S., New York Structural Genomics Research Consortium (NYSGRC)
PDB entry 4hy4: Crystal structure of cIAP1 BIR3 bound to T3170284
Classification: LIGASE/LIGASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.249 Å
Deposited: 2012-11-12
Authors: Dougan, D.R., Mol, C.D., Snell, G.P.
PDB entry 4hy5: Crystal structure of cIAP1 BIR3 bound to T3256336
Classification: LIGASE/LIGASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.752 Å
Deposited: 2012-11-13
Authors: Dougan, D.R., Snell, G.P.
PDB entry 4hy6: Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ1
Classification: Chaperone/Chaperone Inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.649 Å
Deposited: 2012-11-13
Authors: Yang, M., Li, J., He, J.H.
PDB entry 4hy7: Structural and biochemical characterization of a cytosolic wheat cyclophilin TaCypA-1
Classification: ISOMERASE/INHIBITOR
Source organism: Tolypocladium inflatum; Triticum aestivum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.2 Å
Deposited: 2012-11-13
Authors: Sekhon, S.S., Jeong, D.G., Woo, E.J., Singh, P., Pareek, A., Yoon, T.-S.
PDB entry 4hy8: Structures of PR1 and PR2 intermediates from time-resolved laue crystallography
Classification: LUMINESCENT PROTEIN
Source organism: Halorhodospira halophila
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6 Å
Deposited: 2012-11-13
Authors: Jung, Y.O., Lee, J.H., Kim, J., Schmidt, M., Vukica, S., Wulff, M., Moffat, K.
PDB entry 4hy9: Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZZ (residues 1 to 11)
Classification: CHAPERONE, PEPTIDE BINDING PROTEIN
Source organism: Escherichia coli; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 1.55 Å
Deposited: 2012-11-13
Authors: Zahn, M., Straeter, N.
PDB entry 4hya: HYALURONIC ACID, THE ROLE OF DIVALENT CATIONS IN CONFORMATION AND PACKING
Classification: TEXTURE OF CONNECTIVE TISSUE
Experimental method: FIBER DIFFRACTION
Resolution: 3 Å
Deposited: 1977-11-20
Authors: Arnott, S.
PDB entry 4hyb: Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZI (residues 1 to 10)
Classification: CHAPERONE, PEPTIDE BINDING PROTEIN
Source organism: Escherichia coli; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-13
Authors: Zahn, M., Straeter, N.
PDB entry 4hyc: Structure of a presenilin family intramembrane aspartate protease in P2 space group
Classification: MEMBRANE PROTEIN
Source organism: Methanoculleus marisnigri JR1
Experimental method: X-RAY DIFFRACTION
Resolution: 3.95 Å
Deposited: 2012-11-13
Authors: Li, X., Dang, S., Yan, C., Wang, J., Shi, Y.
PDB entry 4hyd: Structure of a presenilin family intramembrane aspartate protease in C2221 space group
Classification: MEMBRANE PROTEIN
Source organism: Methanoculleus marisnigri JR1
Experimental method: X-RAY DIFFRACTION
Resolution: 3.8 Å
Deposited: 2012-11-13
Authors: Li, X., Dang, S., Yan, C., Wang, J., Shi, Y.
PDB entry 4hye: Crystal structure of a response regulator spr1814 from Streptococcus pneumoniae reveals unique interdomain contacts among NarL family proteins
Classification: TRANSCRIPTION ACTIVATOR
Source organism: Streptococcus pneumoniae
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-13
Authors: Park, A.K., Moon, J.H., Chi, Y.M.
PDB entry 4hyf: Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.8 Å
Deposited: 2012-11-13
Authors: Perdreau, H., Ekblad, B., Voronkov, A., Holsworth, D.D., Waaler, J., Drewes, G., Schueler, H., Krauss, S., Morth, J.P.
PDB entry 4hyg: Structure of a presenilin family intramembrane aspartate protease in C222 space group
Classification: MEMBRANE PROTEIN
Source organism: Methanoculleus marisnigri JR1
Experimental method: X-RAY DIFFRACTION
Resolution: 3.32 Å
Deposited: 2012-11-13
Authors: Li, X., Dang, S., Yan, C., Wang, J., Shi, Y.
PDB entry 4hyh: X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-13
Authors: Fischmann, T.O.
PDB entry 4hyi: X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.399 Å
Deposited: 2012-11-13
Authors: Fischmann, T.O.
PDB entry 4hyj: Crystal structure of Exiguobacterium sibiricum rhodopsin
Classification: PROTON TRANSPORT
Source organism: Exiguobacterium sibiricum
Experimental method: X-RAY DIFFRACTION
Resolution: 2.3 Å
Deposited: 2012-11-13
Authors: Gushchin, I., Chervakov, P., Kuzmichev, P., Popov, A., Round, E., Borshchevskiy, V., Dolgikh, D., Kirpichnikov, M., Petrovskaya, L., Chupin, V., Arseniev, A., Gordeliy, V.
PDB entry 4hyk: Dbh Ternary Complex (substrates partially disordered)
Classification: TRANSFERASE/DNA
Source organism: Sulfolobus acidocaldarius; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 2.802 Å
Deposited: 2012-11-13
Authors: Pata, J.D., Wilson, R.C.
PDB entry 4hyl: The crystal structure of an anti-sigma-factor antagonist from Haliangium ochraceum DSM 14365
Classification: TRANSCRIPTION REGULATOR
Source organism: Haliangium ochraceum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.751 Å
Deposited: 2012-11-13
Authors: Tan, K., Chhor, G., Clancy, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
PDB entry 4hym: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: Isomerase/Isomerase inhibitor
Source organism: Francisella tularensis subsp. holarctica LVS
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9 Å
Deposited: 2012-11-13
Authors: Bensen, D.C., Creighton, C.J., Kwan, B., Tari, L.W.
PDB entry 4hyn: X-ray crystal structure of Thermotoga maritima FliY
Classification: SIGNALING PROTEIN
Source organism: Thermotoga maritima
Experimental method: X-RAY DIFFRACTION
Resolution: 2.5 Å
Deposited: 2012-11-13
Authors: Crane, B.R., Sircar, R., Bilwes, A.M.
PDB entry 4hyo: Crystal Structure of MthK Pore
Classification: METAL TRANSPORT
Source organism: Methanothermobacter thermautotrophicus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.65 Å
Deposited: 2012-11-13
Authors: Posson, D.J., McCoy, J.G., Nimigean, C.M.
PDB entry 4hyp: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: Isomerase/Isomerase inhibitor
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.6 Å
Deposited: 2012-11-13
Authors: Bensen, D.C., Creighton, C.J., Tari, L.W.
PDB entry 4hyq: Crystal structure of phospholipase A1 from Streptomyces albidoflavus NA297
Classification: HYDROLASE
Source organism: Streptomyces albidoflavus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.75 Å
Deposited: 2012-11-14
Authors: Murayama, K., Sugimori, D.
PDB entry 4hyr: Structure of putative Glucarate dehydratase from Acidaminococcus sp. D21 with unusual static disorder
Classification: LYASE
Source organism: Acidaminococcus sp. D21
Experimental method: X-RAY DIFFRACTION
Resolution: 1.84 Å
Deposited: 2012-11-14
Authors: Hegde, R.P., Toro, R., Burley, S.K., Almo, S.C., Ramagopal, U.A., New York Structural Genomics Research Consortium (NYSGRC)
PDB entry 4hys: Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 2.415 Å
Deposited: 2012-11-14
Authors: Kuglstatter, A., Janson, C.
PDB entry 4hyt: Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site
Classification: HYDROLASE/MEMBRANE PROTEIN
Source organism: Sus scrofa
Experimental method: X-RAY DIFFRACTION
Resolution: 3.404 Å
Deposited: 2012-11-14
Authors: Laursen, M., Yatime, L., Nissen, P., Fedosova, N.U.
PDB entry 4hyu: Crystal structure of JNK1 in complex with JIP1 peptide and 4-{4-[4-(3-Methanesulfonyl-propoxy)-indazol-1-yl]-pyrimidin-2-ylamino}-cyclohexan
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 2.152 Å
Deposited: 2012-11-14
Authors: Kuglstatter, A., Ghate, M.
PDB entry 4hyv: Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium, PEP and F26BP
Classification: TRANSFERASE
Source organism: Trypanosoma brucei brucei
Experimental method: X-RAY DIFFRACTION
Resolution: 2.3 Å
Deposited: 2012-11-14
Authors: Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
PDB entry 4hyw: Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium and F26BP
Classification: TRANSFERASE
Source organism: Trypanosoma brucei brucei
Experimental method: X-RAY DIFFRACTION
Resolution: 2.35 Å
Deposited: 2012-11-14
Authors: Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
PDB entry 4hyx: Crystal Structure Analysis of the Bacteriorhodopsin in Facial Amphiphile-4 DMPC Bicelle
Classification: PROTON TRANSPORT
Source organism: Halobacterium salinarum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.99 Å
Deposited: 2012-11-14
Authors: Lee, S., Stout, C.D., Zhang, Q.
PDB entry 4hyy: Filament of octameric rings of DMC1 recombinase from Homo sapiens
Classification: RECOMBINATION
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.603 Å
Deposited: 2012-11-14
Authors: Du, L., Luo, Y.
PDB entry 4hyz: Crystal structure of a DUF3887 family protein (RUMGNA_01855) from Ruminococcus gnavus ATCC 29149 at 2.25 A resolution
Classification: STRUCTURAL GENOMICS, UNKNOWN FUNCTION
Source organism: Ruminococcus gnavus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.25 Å
Deposited: 2012-11-14
Authors: Joint Center for Structural Genomics (JCSG)
PDB entry 4hz0: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
Classification: Isomerase/Isomerase inhibitor
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-14
Authors: Bensen, D.C., Trzoss, M., Tari, L.W.
PDB entry 4hz1: Crystal Structure of Pseudomonas aeruginosa azurin with iron(II) at the copper-binding site.
Classification: ELECTRON TRANSPORT
Source organism: Pseudomonas aeruginosa
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-14
Authors: McLaughlin, M.P., Retegan, M., Bill, E., Payne, T.M., Shafaat, H.S., Pea, S., Sudhamsu, J., Ensign, A.A., Crane, B.R., Neese, F., Holland, P.L.
PDB entry 4hz2: Crystal structure of glutathione s-transferase xaut_3756 (target efi-507152) from xanthobacter autotrophicus py2
Classification: TRANSFERASE
Source organism: Xanthobacter autotrophicus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5 Å
Deposited: 2012-11-14
Authors: Patskovsky, Y., Toro, R., Bhosle, R., Hillerich, B., Seidel, R.D., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Zencheck, W.D., Imker, H.J., Al Obaidi, N.F., Stead, M., Love, J., Gerlt, J.A., Armstrong, R.N., Almo, S.C., Enzyme Function Initiative (EFI)
PDB entry 4hz3: MthK pore crystallized in presence of TBSb
Classification: METAL TRANSPORT
Source organism: Methanothermobacter thermautotrophicus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-14
Authors: Posson, D.J., McCoy, J.G., Nimigean, C.M.
PDB entry 4hz4: Crystal structure of glutathione s-transferase b4xh91 (target efi-501787) from actinobacillus pleuropneumoniae
Classification: TRANSFERASE
Source organism: Actinobacillus pleuropneumoniae
Experimental method: X-RAY DIFFRACTION
Resolution: 1.62 Å
Deposited: 2012-11-14
Authors: Patskovsky, Y., Toro, R., Bhosle, R., Hillerich, B., Seidel, R.D., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Zencheck, W.D., Imker, H.J., Al Obaidi, N.F., Stead, M., Love, J., Gerlt, J.A., Armstrong, R.N., Almo, S.C., Enzyme Function Initiative (EFI)
PDB entry 4hz5: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Classification: Isomerase/Isomerase inhibitor
Source organism: Enterococcus faecalis
Experimental method: X-RAY DIFFRACTION
Resolution: 2.7 Å
Deposited: 2012-11-14
Authors: Bensen, D.C., Creighton, C.J., Tari, L.W.
PDB entry 4hz6: crystal structure of BglB
Classification: HYDROLASE
Source organism: uncultured bacterium
Experimental method: X-RAY DIFFRACTION
Resolution: 1.4 Å
Deposited: 2012-11-14
Authors: Hwang, K.Y., Nam, K.H.
PDB entry 4hz7: Crystal structure of BglB with glucose
Classification: HYDROLASE
Source organism: Uncultured bacterium
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 2012-11-14
Authors: Hwang, K.Y., Nam, K.H.
PDB entry 4hz8: Crystal structure of BglB with natural substrate
Classification: HYDROLASE
Source organism: Uncultured bacterium
Experimental method: X-RAY DIFFRACTION
Resolution: 1.14 Å
Deposited: 2012-11-14
Authors: Hwang, K.Y., Nam, K.H.
PDB entry 4hz9: Crystal structure of the type VI native effector-immunity complex Tae3-Tai3 from Ralstonia pickettii
Classification: HYDROLASE
Source organism: Ralstonia pickettii
Experimental method: X-RAY DIFFRACTION
Resolution: 2.4 Å
Deposited: 2012-11-14
Authors: Dong, C., Zhang, H., Gao, Z.Q., Dong, Y.H.
PDB entry 4hza: Crystal Structure of the Immunoglobulin variable domain of Nectin-2 in monoclinic form
Classification: CELL ADHESION
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-14
Authors: Ramagopal, U.A., Samanta, D., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
PDB entry 4hzb: Crystal structure of the type VI SeMet effector-immunity complex Tae3-Tai3 from Ralstonia pickettii
Classification: HYDROLASE
Source organism: Ralstonia pickettii
Experimental method: X-RAY DIFFRACTION
Resolution: 2.6 Å
Deposited: 2012-11-15
Authors: Dong, C., Zhang, H., Gao, Z.Q., Dong, Y.H.
PDB entry 4hzc: Crystal structure of Serine acetyltransferase from Brucella abortus strain S19
Classification: TRANSFERASE
Source organism: Brucella abortus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.97 Å
Deposited: 2012-11-15
Authors: Kumar, S., Samudrala, G.
PDB entry 4hzd: Crystal structure of Serine acetyltransferase in complex with Coenzyme A from Brucella abortus strain S19
Classification: TRANSFERASE
Source organism: Brucella abortus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.87 Å
Deposited: 2012-11-15
Authors: Kumar, S., Samudrala, G.
PDB entry 4hze: Crystal structure of human Arginase-2 complexed with inhibitor 9
Classification: Hydrolase/Hydrolase Inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.602 Å
Deposited: 2012-11-15
Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett, P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.
PDB entry 4hzf: structure of the wild type Catabolite gene Activator Protein
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 1.48 Å
Deposited: 2012-11-15
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.
PDB entry 4hzg: Structure of haloalkane dehalogenase DhaA from Rhodococcus rhodochrous
Classification: HYDROLASE
Source organism: Rhodococcus sp.
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95 Å
Deposited: 2012-11-15
Authors: Stsiapanava, A., Weiss, M.S., Mesters, J.R., Kuta Smatanova, I.
PDB entry 4hzh: Structure of recombinant Gla-domainless prothrombin mutant S525A
Classification: HYDROLASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 3.3 Å
Deposited: 2012-11-15
Authors: Pozzi, N., Niu, W., Gohara, D.W., Chen, Z., Di Cera, E.
PDB entry 4hzi: Crystal structure of the Leptospira interrogans ATPase subunit of an orphan ABC transporter
Classification: TRANSPORT PROTEIN
Source organism: Leptospira interrogans serovar Copenhageni
Experimental method: X-RAY DIFFRACTION
Resolution: 1.85 Å
Deposited: 2012-11-15
Authors: Saul, F.A., Haouz, A., Picardeau, M.
PDB entry 4hzk: Crystal structure of free CRM1 (crystal form 2)
Classification: TRANSPORT PROTEIN
Source organism: Chaetomium thermophilum var. thermophilum
Experimental method: X-RAY DIFFRACTION
Resolution: 3.1 Å
Deposited: 2012-11-15
Authors: Monecke, T., Neumann, P., Dickmanns, A., Ficner, R.
PDB entry 4hzl: Neutralizing antibody mAb#8 in complex with the Epitope II of HCV E2 envelope protein
Classification: IMMUNE SYSTEM
Source organism: Mus musculus; Recombinant Hepatitis C virus H77(5'UTR-NS2)/JFH1_V787A,Q1247L
Experimental method: X-RAY DIFFRACTION
Resolution: 2.85 Å
Deposited: 2012-11-15
Authors: Deng, L., Zhang, P.
PDB entry 4hzm: Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide
Classification: hydrolase/hydrolase inhibitor
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Experimental method: X-RAY DIFFRACTION
Resolution: 1.45 Å
Deposited: 2012-11-15
Authors: Bacik, J.P., Mark, B.L.
PDB entry 4hzn: The Structure of the Bifunctional Acetyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double Hot Dog Fold
Classification: TRANSFERASE
Source organism: Streptomyces atroolivaceus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.25 Å
Deposited: 2012-11-15
Authors: Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
PDB entry 4hzo: The Structure of the Bifunctional Acetyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double Hot Dog Fold
Classification: TRANSFERASE,LYASE
Source organism: Streptomyces atroolivaceus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.76 Å
Deposited: 2012-11-15
Authors: Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
PDB entry 4hzp: The Structure of the Bifunctional Acetyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double Hot Dog Fold
Classification: TRANSFERASE,LYASE
Source organism: Streptomyces atroolivaceus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.77 Å
Deposited: 2012-11-15
Authors: Lohman, J.R., Bingman, C.A., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
PDB entry 4hzr: Crystal structure of Ack1 kinase domain
Classification: TRANSFERASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.31 Å
Deposited: 2012-11-15
Authors: Gajiwala, K.S.
PDB entry 4hzs: Crystal structure of Ack1 kinase domain with C-terminal SH3 domain
Classification: TRANSFERASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 3.23 Å
Deposited: 2012-11-15
Authors: Gajiwala, K.S.
PDB entry 4hzt: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-15
Authors: Yao, N., Brecht, E.
PDB entry 4hzu: Structure of a bacterial energy-coupling factor transporter
Classification: HYDROLASE, TRANSPORT PROTEIN
Source organism: Lactobacillus brevis
Experimental method: X-RAY DIFFRACTION
Resolution: 3.53 Å
Deposited: 2012-11-15
Authors: Wang, T.L., Fu, G.B., Pan, X.J., Shi, Y.G.
PDB entry 4hzv: The crystal structure of influenza A neuraminidase N3
Classification: HYDROLASE
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-15
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4hzw: Crystal structure of influenza A neuraminidase N3 complexed with laninamivir
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.701 Å
Deposited: 2012-11-15
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4hzx: Crystal structure of influenza A neuraminidase N3 complexed with oseltamivir
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-15
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4hzy: Crystal structure of influenza A neuraminidase N3-H274Y
Classification: HYDROLASE
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.598 Å
Deposited: 2012-11-16
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4hzz: Crystal structure of influenza neuraminidase N3-H274Y complexed with oseltamivir
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.601 Å
Deposited: 2012-11-16
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4i00: Crystal structure of influenza A neuraminidase N3-H274Y complexed with zanamivir
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Influenza A virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6 Å
Deposited: 2012-11-16
Authors: Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
PDB entry 4i01: Structure of the mutant Catabolite gen activator protein V140L
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.3 Å
Deposited: 2012-11-16
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
PDB entry 4i02: structure of the mutant Catabolite gene activator protein V140A
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 1.75 Å
Deposited: 2012-11-16
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
PDB entry 4i03: Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor
Classification: HYDROLASE/HYDROLASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-16
Authors: Stura, E.A., Vera, L., Devel, L., Cassar-Lajeunesse, E., Dive, V.
PDB entry 4i04: Structure of zymogen of cathepsin B1 from Schistosoma mansoni
Classification: HYDROLASE
Source organism: Schistosoma mansoni
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95 Å
Deposited: 2012-11-16
Authors: Rezacova, P., Jilkova, A., Brynda, J., Horn, M., Mares, M.
PDB entry 4i05: Structure of intermediate processing form of cathepsin B1 from Schistosoma mansoni
Classification: HYDROLASE
Source organism: Schistosoma mansoni
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9 Å
Deposited: 2012-11-16
Authors: Rezacova, P., Jilkova, A., Brynda, J., Horn, M., Mares, M.
PDB entry 4i06: Crystal structure of human Arginase-2 complexed with inhibitor 14
Classification: HYDROLASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-16
Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D.L., Golebiowski, A., Ji, M., Zhang, M., Beckett, P., Sheeler, R., Andreoli, M., Conway, B., Mahboubi, K., Schroeter, H., Van Zandt, M.C., Podjarny, A.
PDB entry 4i07: Structure of mature form of cathepsin B1 from Schistosoma mansoni
Classification: HYDROLASE
Source organism: Schistosoma mansoni
Experimental method: X-RAY DIFFRACTION
Resolution: 1.3 Å
Deposited: 2012-11-16
Authors: Rezacova, P., Jilkova, A., Brynda, J., Horn, M., Mares, M.
PDB entry 4i08: Crystal structure of beta-ketoacyl-acyl carrier protein reductase (FabG) from Vibrio cholerae in complex with NADPH
Classification: OXIDOREDUCTASE
Source organism: Vibrio cholerae O1
Experimental method: X-RAY DIFFRACTION
Resolution: 2.063 Å
Deposited: 2012-11-16
Authors: Hou, J., Chruszcz, M., Zheng, H., Osinski, T., Anderson, W.F., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID)
PDB entry 4i09: structure of the mutant Catabolite gene activator protein V132L
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.05 Å
Deposited: 2012-11-16
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
PDB entry 4i0a: structure of the mutant Catabolite gene activator protein V132A
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-16
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
PDB entry 4i0b: structure of the mutant Catabolite gene activator protein H160L
Classification: TRANSCRIPTION
Source organism: Escherichia coli
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5 Å
Deposited: 2012-11-16
Authors: Pohl, E., Townsend, P.D., Rodgers, T., Burnell, D., McLeish, T.C.B., Wilson, M.R., Cann, M.J.
PDB entry 4i0c: The structure of the camelid antibody cAbHuL5 in complex with human lysozyme
Classification: IMMUNE SYSTEM/HYDROLASE
Source organism: Camelus dromedarius; Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95 Å
Deposited: 2012-11-16
Authors: De Genst, E., Chan, P.H., Pardon, E., Kumita, J.R., Christodoulou, J., Menzer, L., Chirgadze, D.Y., Robinson, C.V., Muyldermans, S., Matagne, A., Wyns, L., Dobson, C.M., Dumoulin, M.
PDB entry 4i0d: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.91 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0e: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0f: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0g: Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.78 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0h: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors.
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0i: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.2 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0j: SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.99 Å
Deposited: 2012-11-16
Authors: Yao, N., Brecht, E.
PDB entry 4i0k: Crystal structure of murine B7-H3 extracellular domain
Classification: IMMUNE SYSTEM
Source organism: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.97 Å
Deposited: 2012-11-16
Authors: Vigdorovich, V., Ramagopal, U., Bonanno, J.B., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
PDB entry 4i0n: Pore forming protein
Classification: TOXIN
Source organism: Clostridium perfringens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-16
Authors: Yan, X., Porter, C.J., Hardy, S.P., Steer, D., Smith, A.I., Quinset, N., Hughes, V., Cheung, J.K., Keyburn, A.L., Kaldhusdal, M., Moore, R.J., Bannam, T.L., Whisstock, J.C., Rood, J.I.
PDB entry 4i0o: Nucleoporin ELYS (aa1-494), Mus musculus
Classification: STRUCTURAL PROTEIN
Source organism: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9 Å
Deposited: 2012-11-17
Authors: Bilokapic, S., Schwartz, T.U.
PDB entry 4i0p: HLA-DO in complex with HLA-DM
Classification: IMMUNE SYSTEM
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 3.2 Å
Deposited: 2012-11-18
Authors: Guce, A.I., Mortimer, S.E., Stern, L.J.
PDB entry 4i0r: Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5-Trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.1 Å
Deposited: 2012-11-19
Authors: Kuglstatter, A., Villasenor, A.G.
PDB entry 4i0s: Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.98 Å
Deposited: 2012-11-19
Authors: Kuglstatter, A., Slade, M.
PDB entry 4i0t: Crystal structure of spleen tyrosine kinase complexed with 2-(5,6,7,8-Tetrahydro-imidazo[1,5-a]pyridin-1-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid tert-butylamide
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7 Å
Deposited: 2012-11-19
Authors: Kuglstatter, A., Slade, M.
PDB entry 4i0u: Improved structure of Thermotoga maritima CorA at 2.7 A resolution
Classification: METAL TRANSPORT
Source organism: Thermotoga maritima
Experimental method: X-RAY DIFFRACTION
Resolution: 2.7 Å
Deposited: 2012-11-19
Authors: Nordin, N., Guskov, A., Phua, T., Sahaf, N., Xia, Y., Lu, S.Y., Eshaghi, H., Eshaghi, S.
PDB entry 4i0w: Structure of the Clostridium Perfringens CspB protease
Classification: HYDROLASE
Source organism: Clostridium perfringens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6 Å
Deposited: 2012-11-19
Authors: Adams, C.M., Eckenroth, B.E., Doublie, S.
PDB entry 4i0x: Crystal structure of the Mycobacterum abscessus EsxEF (Mab_3112-Mab_3113) complex
Classification: Structural Genomics, Unknown Function
Source organism: Mycobacterium abscessus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.956 Å
Deposited: 2012-11-19
Authors: Arbing, M.A., Chan, S., Lu, J., Kuo, E., Harris, L., Eisenberg, D., Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
PDB entry 4i0y: CRYSTAL STRUCTURE OF RABBIT RYANODINE RECEPTOR 1 (RESIDUES 1-536) DISEASE MUTANT C36R
Classification: METAL TRANSPORT
Source organism: Oryctolagus cuniculus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.8 Å
Deposited: 2012-11-19
Authors: Van Petegem, F., Kimlicka, L.
PDB entry 4i0z: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens; SYNTHETIC CONSTRUCT
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8 Å
Deposited: 2012-11-19
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i10: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.07 Å
Deposited: 2012-11-19
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i11: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Classification: transferase/transferase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.89 Å
Deposited: 2012-11-19
Authors: Bowers, B., Xu, Y., Yuan, S., Probst, G.D., Hom, R.K., Chan, W., Konradi, A.W., Sham, H.L., Zhu, Y.L., Beroza, P., Pan, H., Brecht, E., Yao, N., Lougheed, J., Artis, D.R., Tam, D., Bova, M.
PDB entry 4i12: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.78 Å
Deposited: 2012-11-19
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i13: Nanobody ca1697 binding to the DHFR.folate binary complex
Classification: OXIDOREDUCTASE/IMMUNE SYSTEM
Source organism: Escherichia coli; lama glama
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6 Å
Deposited: 2012-11-19
Authors: Oyen, D., Steyaert, J., Barlow, J.N.
PDB entry 4i14: Crystal Structure of Mtb-ribA2 (Rv1415)
Classification: HYDROLASE, LYASE
Source organism: Mycobacterium tuberculosis
Experimental method: X-RAY DIFFRACTION
Resolution: 3 Å
Deposited: 2012-11-20
Authors: Singh, M., Kumar, P., Yadav, S., Gautam, R., Sharma, N., Karthikeyan, S.
PDB entry 4i15: Crystal structure of TbrPDEB1
Classification: HYDROLASE
Source organism: Trypanosoma brucei
Experimental method: X-RAY DIFFRACTION
Resolution: 1.65 Å
Deposited: 2012-11-20
Authors: Wang, H., Ke, H.
PDB entry 4i16: Crystal structure of CARMA1 CARD
Classification: SIGNALING PROTEIN
Source organism: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.751 Å
Deposited: 2012-11-20
Authors: Li, S., Yang, X., Shen, Y.
PDB entry 4i17: Crystal structure of a TPR repeats protein (BF2334) from Bacteroides fragilis NCTC 9343 at 1.50 A resolution
Classification: Structural Genomics, Unknown Function
Source organism: Bacteroides fragilis
Experimental method: X-RAY DIFFRACTION
Resolution: 1.83 Å
Deposited: 2012-11-20
Authors: Joint Center for Structural Genomics (JCSG)
PDB entry 4i18: Crystal structure of human prolactin receptor complexed with Fab fragment
Classification: CYTOKINE, SIGNALING PROTEIN
Source organism: Homo sapiens; Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 3.238 Å
Deposited: 2012-11-20
Authors: Duguid, E.M., Mukherjee, S., Kouadio, J.L.
PDB entry 4i19: The crystal structure of an epoxide hydrolase from Streptomyces carzinostaticus subsp. neocarzinostaticus.
Classification: HYDROLASE
Source organism: Streptomyces carzinostaticus subsp. neocarzinostaticus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.148 Å
Deposited: 2012-11-20
Authors: Tan, K., Bigelow, L., Clancy, S., Babnigg, G., Bingman, C.A., Yennamalli, R., Lohman, J., Ma, M., Shen, B., Phillips Jr., G.N., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
PDB entry 4i1a: Crystal Structure of the Apo Form of RapI
Classification: HYDROLASE
Source organism: Bacillus subtilis subsp. subtilis
Experimental method: X-RAY DIFFRACTION
Resolution: 2.443 Å
Deposited: 2012-11-20
Authors: Parashar, V., Jeffrey, P.D., Neiditch, M.B.
PDB entry 4i1b: FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE
Classification: CYTOKINE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 1990-03-27
Authors: Veerapandian, B., Poulos, T.L., Gilliland, G.L., Raag, R., Svensson, L.A., Masui, Y., Hirai, Y.
PDB entry 4i1c: Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors
Classification: hydrolase/hydrolase inhibitor
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 2012-11-20
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i1d: The crystal structure of an ABC transporter substrate-binding protein from Bradyrhizobium japonicum USDA 110
Classification: TRANSPORT PROTEIN
Source organism: Bradyrhizobium japonicum
Experimental method: X-RAY DIFFRACTION
Resolution: 2.201 Å
Deposited: 2012-11-20
Authors: Fan, Y., Tan, K., Mack, J., Zerbs, S., Collart, F., Joachimiak, A., Midwest Center for Structural Genomics (MCSG)
PDB entry 4i1e: Crystal structure of Rabbit Ryanodine Receptor 1 (residues 1-536) disease mutant G249R
Classification: METAL TRANSPORT
Source organism: Oryctolagus cuniculus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.4 Å
Deposited: 2012-11-20
Authors: Kimlicka, L., Van Petegem, F.
PDB entry 4i1f: Structure of Parkin-S223P E3 ligase
Classification: LIGASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 1.58 Å
Deposited: 2012-11-20
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i1g: dna octamer d(GTseGTACAC) partially crosslinked with two platinums
Classification: DNA
Experimental method: X-RAY DIFFRACTION
Resolution: 1.25 Å
Deposited: 2012-11-20
Authors: Zhang, W., Coronado, G., Huang, Z.
PDB entry 4i1h: Structure of Parkin E3 ligase
Classification: LIGASE
Source organism: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2 Å
Deposited: 2012-11-20
Authors: Lougheed, J.C., Brecht, E., Yao, N.H.
PDB entry 4i1i: Crystal structure of a putative Cytosolic malate dehydrogenase from Leishmania major Friedlin in complex with NAD
Classification: OXIDOREDUCTASE
Source organism: Leishmania major
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5 Å
Deposited: 2012-11-21
Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)
PDB entry 4i1k: Crystal Structure of VRN1 (Residues 208-341)
Classification: DNA BINDING PROTEIN
Source organism: Arabidopsis thaliana
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6 Å
Deposited: 2012-11-21
Authors: King, G., Chanson, A.H., McCallum, E.J., Ohme-Takagi, M., Byriel, K., Hill, J.M., Martin, J.L., Mylne, J.S.
PDB entry 4i1l: Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function
Classification: TRANSCRIPTION REGULATOR
Source organism: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.1 Å
Deposited: 2012-11-21
Authors: Song, X.M., Greene, M.I., Zhou, Z.C.
PDB entry 4i1m: Crystal structure of the Legionella pneumophila GAP domain of LepB
Classification: HYDROLASE
Source organism: Legionella pneumophila subsp. pneumophila
Experimental method: X-RAY DIFFRACTION
Resolution: 2.804 Å
Deposited: 2012-11-21
Authors: Streller, A., Gazdag, E.M., Vetter, I.R., Goody, R.S., Itzen, A.
PDB entry 4i1n: R104A-ca1697 nanobody binding to the binary DHFR.folate complex
Classification: OXIDOREDUCTASE/IMMUNE SYSTEM
Source organism: Escherichia coli; lama glama
Experimental method: X-RAY DIFFRACTION
Resolution: 1.888 Å
Deposited: 2012-11-21
Authors: Oyen, D., Steyaert, J., Barlow, J.N.