Reference: Michelle P Aranha; Thomas A Penfound; Jay A Spencer; Rupesh Agarwal; Jerome Baudry; James B Dale; Jeremy C Smith. "Structure-based group A streptococcal vaccine design: Helical wheel homology predicts antibody cross-reactivity among streptococcal M protein-derived peptides." The Journal of biological chemistry (2020).

Epitope: M1
Chemical type: Peptide from protein
Sequence: NGDGNPREVIEDLAANNPAIQNIRLRHENKDLKARLENAMEVAGRDFKRA
Position: 42-91
Source molecule (GenBank): CAA30757.1
Assay category: BCell
Result: Positive-Low

Epitope: M1
Chemical type: Peptide from protein
Sequence: NGDGNPREVIEDLAANNPAIQNIRLRHENKDLKARLENAMEVAGRDFKRA
Position: 42-91
Source molecule (GenBank): CAA30757.1
Assay category: BCell
Result: Positive

Epitope: M1
Chemical type: Peptide from protein
Sequence: NGDGNPREVIEDLAANNPAIQNIRLRHENKDLKARLENAMEVAGRDFKRA
Position: 42-91
Source molecule (GenBank): CAA30757.1
Assay category: BCell
Result: Positive

Epitope: M1
Chemical type: Peptide from protein
Sequence: NGDGNPREVIEDLAANNPAIQNIRLRHENKDLKARLENAMEVAGRDFKRA
Position: 42-91
Source molecule (GenBank): CAA30757.1
Assay category: BCell
Result: Positive

Epitope: M2
Chemical type: Peptide from protein
Sequence: NSKNPVPVKKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEE
Position: 42-91
Source molecule (GenBank): WP_115243396.1
Assay category: BCell
Result: Positive

Epitope: M2
Chemical type: Peptide from protein
Sequence: NSKNPVPVKKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEE
Position: 42-91
Source molecule (GenBank): WP_115243396.1
Assay category: BCell
Result: Positive

Epitope: M2
Chemical type: Peptide from protein
Sequence: NSKNPVPVKKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEE
Position: 42-91
Source molecule (GenBank): WP_115243396.1
Assay category: BCell
Result: Positive

Epitope: M2
Chemical type: Peptide from protein
Sequence: NSKNPVPVKKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEE
Position: 42-91
Source molecule (GenBank): WP_115243396.1
Assay category: BCell
Result: Positive

Epitope: M9
Chemical type: Peptide from protein
Sequence: EGVKKAEEAKLSVPKTEYDKLYDDYDKLQEKSAEYLERIGELEERQKNLE
Position: 42-91
Source molecule (GenBank): WP_111693435.1
Assay category: BCell
Result: Positive

Epitope: M9
Chemical type: Peptide from protein
Sequence: EGVKKAEEAKLSVPKTEYDKLYDDYDKLQEKSAEYLERIGELEERQKNLE
Position: 42-91
Source molecule (GenBank): WP_111693435.1
Assay category: BCell
Result: Positive

Epitope: M9
Chemical type: Peptide from protein
Sequence: EGVKKAEEAKLSVPKTEYDKLYDDYDKLQEKSAEYLERIGELEERQKNLE
Position: 42-91
Source molecule (GenBank): WP_111693435.1
Assay category: BCell
Result: Positive

Epitope: M49
Chemical type: Peptide from protein
Sequence: VEKKVEAKVEAAENNVSSVARREKELYDQIADLTDKNGEYLERIGELEER
Position: 20-69
Source molecule (GenBank): ACL51809.1
Assay category: BCell
Result: Positive

Epitope: M49
Chemical type: Peptide from protein
Sequence: VEKKVEAKVEAAENNVSSVARREKELYDQIADLTDKNGEYLERIGELEER
Position: 20-69
Source molecule (GenBank): ACL51809.1
Assay category: BCell
Result: Positive

Epitope: M49
Chemical type: Peptide from protein
Sequence: VEKKVEAKVEAAENNVSSVARREKELYDQIADLTDKNGEYLERIGELEER
Position: 20-69
Source molecule (GenBank): ACL51809.1
Assay category: BCell
Result: Positive

Epitope: M50
Chemical type: Peptide from protein
Sequence: EEAGASRTITSSENISKLYDENSKLIEERADLLGKLEEKEDKLESVERHY
Position: 42-91
Source molecule (GenBank): WP_111695005.1
Assay category: BCell
Result: Positive-Low

Epitope: M50
Chemical type: Peptide from protein
Sequence: EEAGASRTITSSENISKLYDENSKLIEERADLLGKLEEKEDKLESVERHY
Position: 42-91
Source molecule (GenBank): WP_111695005.1
Assay category: BCell
Result: Positive-Low

Epitope: M50
Chemical type: Peptide from protein
Sequence: EEAGASRTITSSENISKLYDENSKLIEERADLLGKLEEKEDKLESVERHY
Position: 42-91
Source molecule (GenBank): WP_111695005.1
Assay category: BCell
Result: Negative

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive-Low

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive

Epitope: M73
Chemical type: Peptide from protein
Sequence: DNQSPAPVKKEAKKLNEAELYNKIQELEEGKAELFDKLEKVEEENKKVKE
Position: 19-68
Source molecule (GenBank): ACL51810.1
Assay category: BCell
Result: Positive

Epitope: M77
Chemical type: Peptide from protein
Sequence: EGVSVGSDASLHNRITDLEEEREKLLNKLDKVEEEHKKDHEQLEKKSEDV
Position: 42-91
Source molecule (GenBank): WP_111674382.1
Assay category: BCell
Result: Positive

Epitope: M77
Chemical type: Peptide from protein
Sequence: EGVSVGSDASLHNRITDLEEEREKLLNKLDKVEEEHKKDHEQLEKKSEDV
Position: 42-91
Source molecule (GenBank): WP_111674382.1
Assay category: BCell
Result: Positive-Low

Epitope: M77
Chemical type: Peptide from protein
Sequence: EGVSVGSDASLHNRITDLEEEREKLLNKLDKVEEEHKKDHEQLEKKSEDV
Position: 42-91
Source molecule (GenBank): WP_111674382.1
Assay category: BCell
Result: Positive

Epitope: M77
Chemical type: Peptide from protein
Sequence: EGVSVGSDASLHNRITDLEEEREKLLNKLDKVEEEHKKDHEQLEKKSEDV
Position: 42-91
Source molecule (GenBank): WP_111674382.1
Assay category: BCell
Result: Positive

Epitope: M77
Chemical type: Peptide from protein
Sequence: EGVSVGSDASLHNRITDLEEEREKLLNKLDKVEEEHKKDHEQLEKKSEDV
Position: 42-91
Source molecule (GenBank): WP_111674382.1
Assay category: BCell
Result: Positive-Low

Epitope: M84
Chemical type: Peptide from protein
Sequence: DSDNNRSASVKKNNEEELHNKIADLLDQNEEYLNKIDELKEGLEAKEKSS
Position: 17-66
Source molecule (GenBank): AAA99570.1
Assay category: BCell
Result: Positive

Epitope: M84
Chemical type: Peptide from protein
Sequence: DSDNNRSASVKKNNEEELHNKIADLLDQNEEYLNKIDELKEGLEAKEKSS
Position: 17-66
Source molecule (GenBank): AAA99570.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M89
Chemical type: Peptide from protein
Sequence: DSDNINRSVSVKDNEKELHNKIADLEEERGEHLDKIDELKEELKAKEKSS
Position: 33-82
Source molecule (GenBank): ACN88175.1
Assay category: BCell
Result: Positive

Epitope: M102
Chemical type: Peptide from protein
Sequence: DNPSSVPVKKAAELYDKIKELEEGREELLNDLDKVKEEHKKDHEKLEKKA
Position: 1-50
Source molecule (GenBank): AHM94184.1
Assay category: BCell
Result: Positive-Low

Epitope: M102
Chemical type: Peptide from protein
Sequence: DNPSSVPVKKAAELYDKIKELEEGREELLNDLDKVKEEHKKDHEKLEKKA
Position: 1-50
Source molecule (GenBank): AHM94184.1
Assay category: BCell
Result: Positive

Epitope: M112
Chemical type: Peptide from protein
Sequence: DNNSSSVSVKNEVKLHNEIAALQEEKEKLLNELDNVKEEHKKDLDKVKEE
Position: 35-84
Source molecule (GenBank): ABO71767.1
Assay category: BCell
Result: Positive-Low

Epitope: M112
Chemical type: Peptide from protein
Sequence: DNNSSSVSVKNEVKLHNEIAALQEEKEKLLNELDNVKEEHKKDLDKVKEE
Position: 35-84
Source molecule (GenBank): ABO71767.1
Assay category: BCell
Result: Positive

Epitope: M114
Chemical type: Peptide from protein
Sequence: NSKNPAPAPASAVPVKKEATKLSEAELYNKIQELEEGKAELFDKLEKVEE
Position: 42-91
Source molecule (GenBank): WP_053308639.1
Assay category: BCell
Result: Positive

Epitope: M114
Chemical type: Peptide from protein
Sequence: NSKNPAPAPASAVPVKKEATKLSEAELYNKIQELEEGKAELFDKLEKVEE
Position: 42-91
Source molecule (GenBank): WP_053308639.1
Assay category: BCell
Result: Positive

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive-Low

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive-Low

Epitope: M118
Chemical type: Peptide from protein
Sequence: AEKKVEVADSNASSVAKLYNQIADLTDKNGEYLERIEELEERQKNLEKLE
Position: 42-91
Source molecule (GenBank): WP_030126221.1
Assay category: BCell
Result: Positive

Epitope: M124
Chemical type: Peptide from protein
Sequence: NSKTPAPAPAVPVKKEATKSKLSEAELHDKIKNLEEEKAELFEKLDKVEE
Position: 24-73
Source molecule (GenBank): AAD34608.1
Assay category: BCell
Result: Positive

Epitope: M124
Chemical type: Peptide from protein
Sequence: NSKTPAPAPAVPVKKEATKSKLSEAELHDKIKNLEEEKAELFEKLDKVEE
Position: 24-73
Source molecule (GenBank): AAD34608.1
Assay category: BCell
Result: Positive

Epitope: M175
Chemical type: Peptide from protein
Sequence: DNKDSVSVKNEAKPKLKEAELHDKIADLEEEKAELLNKLDKVEEEHKKDH
Position: 1-50
Source molecule (GenBank): AFV60867.1
Assay category: BCell
Result: Positive

Epitope: M175
Chemical type: Peptide from protein
Sequence: DNKDSVSVKNEAKPKLKEAELHDKIADLEEEKAELLNKLDKVEEEHKKDH
Position: 1-50
Source molecule (GenBank): AFV60867.1
Assay category: BCell
Result: Positive

Epitope: M183
Chemical type: Peptide from protein
Sequence: EEAKEAKTVKYEVYSQLHDDYDKLQEQNGEYLKKIGELEERQKNLEKLER
Position: 1-50
Source molecule (GenBank): AHM94228.1
Assay category: BCell
Result: Positive-Low

Epitope: M183
Chemical type: Peptide from protein
Sequence: EEAKEAKTVKYEVYSQLHDDYDKLQEQNGEYLKKIGELEERQKNLEKLER
Position: 1-50
Source molecule (GenBank): AHM94228.1
Assay category: BCell
Result: Positive-Low

Epitope: M183
Chemical type: Peptide from protein
Sequence: EEAKEAKTVKYEVYSQLHDDYDKLQEQNGEYLKKIGELEERQKNLEKLER
Position: 1-50
Source molecule (GenBank): AHM94228.1
Assay category: BCell
Result: Positive

Epitope: M227
Chemical type: Peptide from protein
Sequence: NGDGNPIRHENKDLKARLENAMEVAGRDFKRAEELEKAKQALEDQRKDLE
Position: 1-50
Source molecule (GenBank): AFV60911.1
Assay category: BCell
Result: Positive

Epitope: M227
Chemical type: Peptide from protein
Sequence: NGDGNPIRHENKDLKARLENAMEVAGRDFKRAEELEKAKQALEDQRKDLE
Position: 1-50
Source molecule (GenBank): AFV60911.1
Assay category: BCell
Result: Positive

Epitope: M232
Chemical type: Peptide from protein
Sequence: DSDNSNSNRSAVSVKNNEEKLHNKIADLLDQNEEYLNKIDELKEELEAKE
Position: 22-71
Source molecule (GenBank): AAY30316.1
Assay category: BCell
Result: Positive

Epitope: M232
Chemical type: Peptide from protein
Sequence: DSDNSNSNRSAVSVKNNEEKLHNKIADLLDQNEEYLNKIDELKEELEAKE
Position: 22-71
Source molecule (GenBank): AAY30316.1
Assay category: BCell
Result: Positive

Epitope: M238
Chemical type: Peptide from protein
Sequence: NNDGRSRDVTEEIAANNTTVQNIRLRNENKNLKAKNEDLKARLENAMNVA
Assay category: BCell
Result: Positive-Low

Epitope: M238
Chemical type: Peptide from protein
Sequence: NNDGRSRDVTEEIAANNTTVQNIRLRNENKNLKAKNEDLKARLENAMNVA
Assay category: BCell
Result: Positive

Epitope: M239
Chemical type: Peptide from protein
Sequence: NENVGPRDVVKELVEKDPVLQNKRLRSENQKLKESLENARDVAGRDFKRA
Position: 35-84
Source molecule (GenBank): ABO71777.1
Assay category: BCell
Result: Positive

Epitope: M239
Chemical type: Peptide from protein
Sequence: NENVGPRDVVKELVEKDPVLQNKRLRSENQKLKESLENARDVAGRDFKRA
Position: 35-84
Source molecule (GenBank): ABO71777.1
Assay category: BCell
Result: Positive