Reference: Yang Wang; Tomasz Sosinowski; Andrey Novikov; Frances Crawford; David B Neau; Junbao Yang; William W Kwok; Philippa Marrack; John W Kappler; Shaodong Dai. "C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes." Proceedings of the National Academy of Sciences of the United States of America (2018).

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 49000.0
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 54000.0
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 2.65
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Negative

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 5100.0
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 6980.0
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Positive
Quantitative measurement: 0.036
Host:  12-24 weeks

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: TCell
Result: Negative

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.96

Epitope: MHC-linked 8E9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEE
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.8

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 0.5

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 90000.0

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 0.0315

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 100000.0
Host:  12-24 weeks

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 5800.0

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 10000.0

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Positive
Quantitative measurement: 3500.0

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: TCell
Result: Negative
Host:  12-24 weeks

Epitope: MHC-linked 8G9E
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGGE
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.32

Epitope: MHC-linked 8E9E11ss
Chemical type: Peptide, no natural source
Sequence: HLVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: MHC-linked 8E9E11ss
Chemical type: Peptide, no natural source
Sequence: HLVEELYLVAGEEGC
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.94

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Negative
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Positive-Low
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble wt8E9R
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGER
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Negative
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive-High
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive-High
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8E9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEE
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive-Low
Host: F 12 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: soluble 8G9E
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGGE
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Cell Line / Clone (Hybridoma)