Reference: Arvind Sharma; Xiaokang Zhang; Wanwisa Dejnirattisai; Xinghong Dai; Danyang Gong; Wiyada Wongwiwat; Stéphane Duquerroy; Alexander Rouvinski; Marie-Christine Vaney; Pablo Guardado-Calvo; Ahmed Haouz; Patrick England; Ren Sun; Z Hong Zhou; Juthathip Mongkolsapaya; Gavin R Screaton; Felix A Rey. "The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses." Cell (2021).

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.42

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 18.4

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.58

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.03

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 16.2

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 20.7

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 25.3

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV1 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: R282, E324, L326, H429, Q430, V431, K590, E642, K643
Source molecule (GenBank): AAF82039.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.41

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 25.3

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 18.4

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.42

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 16.2

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 20.7

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.03

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.19

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.41

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.58

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV3 sE
Chemical type: Region on multi-chain protein
Discontinuous residues: A: N265, T268, D269, S270, R271, C272, R297, W299, G300, N301, G302, C303, G304, E445; B: R200, G226, G227, E242, L243, Q244, I338, K505, K506, K519, E521, K557, E558, E559
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of Fab C8 on DENV3 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: Q348, K505, K506, E507
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.65

Epitope: Epitope of Fab C8 on DENV3 sE
Chemical type: Discontinuous protein residues
Discontinuous residues: Q348, K505, K506, E507
Source molecule (GenBank): AAK18606.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 18.4

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 16.2

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 20.7

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 25.3

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.42

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.03

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.58

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv C10 on DENV2 virion
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N347, T350, D351, S352, C354, R379, G382, N383, G384, C385, G386, H524, K526, K527, D529; C: I326, E428, K437, H438, F559, V589, R603, D642, P644
Source molecule (GenBank): AAC59275.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.41