Reference: Wolfgang Faigle; Carolina Cruciani; Witold Wolski; Bernd Roschitzki; Marco Puthenparampil; Paula Tomas-Ojer; Carla Sellés-Moreno; Thomas Zeis; Ivan Jelcic; Nicole Schaeren-Wiemers; Mireia Sospedra; Roland Martin. "Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4<sup>+</sup> T Cells in Multiple Sclerosis." Frontiers in immunology (2019).

Epitope: MBP-C (20-40)
Chemical type: Peptide from protein
Sequence: TMDHARHGFLPRHRDTGILDS
Position: 21-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (20-40)
Chemical type: Peptide from protein
Sequence: TMDHARHGFLPRHRDTGILDS
Position: 21-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (38-56)
Chemical type: Peptide from protein
Sequence: LDSIGRFFGGDRGAPKRGS
Position: 39-57
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (38-56)
Chemical type: Peptide from protein
Sequence: LDSIGRFFGGDRGAPKRGS
Position: 39-57
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (94-117)
Chemical type: Peptide from protein
Sequence: VTPRTPPPSQGKGRGLSLSRFSWG
Position: 95-118
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (94-117)
Chemical type: Peptide from protein
Sequence: VTPRTPPPSQGKGRGLSLSRFSWG
Position: 95-118
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (108-126)
Chemical type: Peptide from protein
Sequence: GLSLSRFSWGAEGQRPGFG
Position: 109-127
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (108-126)
Chemical type: Peptide from protein
Sequence: GLSLSRFSWGAEGQRPGFG
Position: 109-127
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (115-135)
Chemical type: Peptide from protein
Sequence: SWGAEGQRPGFGYGGRASDYK
Position: 116-136
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (115-135)
Chemical type: Peptide from protein
Sequence: SWGAEGQRPGFGYGGRASDYK
Position: 116-136
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (146-170)
Chemical type: Peptide from protein
Sequence: AQGTLSKIFKLGGRDSRSGSPMARR
Position: 147-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (146-170)
Chemical type: Peptide from protein
Sequence: AQGTLSKIFKLGGRDSRSGSPMARR
Position: 147-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (20-40)
Chemical type: Peptide from protein
Sequence: TMDHARHGFLPRHRDTGILDS
Position: 21-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (20-40)
Chemical type: Peptide from protein
Sequence: TMDHARHGFLPRHRDTGILDS
Position: 21-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (38-56)
Chemical type: Peptide from protein
Sequence: LDSIGRFFGGDRGAPKRGS
Position: 39-57
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (38-56)
Chemical type: Peptide from protein
Sequence: LDSIGRFFGGDRGAPKRGS
Position: 39-57
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (61-82)
Chemical type: Peptide from protein
Sequence: HHPARTAHYGSLPQKSHGRTQD
Position: 62-83
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (61-82)
Chemical type: Peptide from protein
Sequence: HHPARTAHYGSLPQKSHGRTQD
Position: 62-83
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (83-106)
Chemical type: Peptide from protein
Sequence: ENPVVHFFKNIVTPRTPPPSQGKG
Position: 84-107
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (83-106)
Chemical type: Peptide from protein
Sequence: ENPVVHFFKNIVTPRTPPPSQGKG
Position: 84-107
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (94-117)
Chemical type: Peptide from protein
Sequence: VTPRTPPPSQGKGRGLSLSRFSWG
Position: 95-118
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (94-117)
Chemical type: Peptide from protein
Sequence: VTPRTPPPSQGKGRGLSLSRFSWG
Position: 95-118
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (108-126)
Chemical type: Peptide from protein
Sequence: GLSLSRFSWGAEGQRPGFG
Position: 109-127
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (108-126)
Chemical type: Peptide from protein
Sequence: GLSLSRFSWGAEGQRPGFG
Position: 109-127
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (115-135)
Chemical type: Peptide from protein
Sequence: SWGAEGQRPGFGYGGRASDYK
Position: 116-136
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (115-135)
Chemical type: Peptide from protein
Sequence: SWGAEGQRPGFGYGGRASDYK
Position: 116-136
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (146-170)
Chemical type: Peptide from protein
Sequence: AQGTLSKIFKLGGRDSRSGSPMARR
Position: 147-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (146-170)
Chemical type: Peptide from protein
Sequence: AQGTLSKIFKLGGRDSRSGSPMARR
Position: 147-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (146-170)
Chemical type: Peptide from protein
Sequence: AQGTLSKIFKLGGRDSRSGSPMARR
Position: 147-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (83-99)
Chemical type: Peptide from protein
Sequence: ENPVVHFFKNIVTPRT
Position: 84-99
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Negative
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-C (111-129)
Chemical type: Peptide from protein
Sequence: LSRFSWGAEGQRPGFGYGG
Position: 112-130
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (13-32)
Chemical type: Peptide from protein
Sequence: KYLATASTMDHARHGFLPRH
Position: 14-33
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (83-99)
Chemical type: Peptide from protein
Sequence: ENPVVHFFKNIVTPRT
Position: 84-99
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MBP-R (111-129)
Chemical type: Peptide from protein
Sequence: LSRFSWGAEGQRPGFGYGG
Position: 112-130
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: PLP-(139-154)
Chemical type: Peptide from protein
Sequence: HCLGKWLGHPDKFVGI
Position: 140-155
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MOG-(1-20)
Chemical type: Peptide from protein
Sequence: GQFRVIGPRHPIRALVGDEV
Position: 30-49
Source molecule (GenBank): CAQ06612.1
Assay category: TCell
Result: Positive-Low
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo

Epitope: MOG-(35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRPPFSRVVHLYRNGK
Position: 64-84
Source molecule (GenBank): CAQ06612.1
Assay category: TCell
Result: Positive-High
MHC allele types: 436 424 57
Host:  17-58 years
Cell type: T cell CD4+
Tissue: cerebrospinal fluid (CSF)
Culture conditions: Direct Ex Vivo