Reference: Maryam Mukhamedova; Daniel Wrapp; Chen-Hsiang Shen; Morgan S A Gilman; Tracy J Ruckwardt; Chaim A Schramm; Larissa Ault; Lauren Chang; Alexandrine Derrien-Colemyn; Sarah A M Lucas; Amy Ransier; Samuel Darko; Emily Phung; Lingshu Wang; Yi Zhang; Scott A Rush; Bharat Madan; Guillaume B E Stewart-Jones; Pamela J Costner; LaSonji A Holman; Somia P Hickman; Nina M Berkowitz; Nicole A Doria-Rose; Kaitlyn M Morabito; Brandon J DeKosky; Martin R Gaudinski; Grace L Chen; Michelle C Crank; John Misasi; Nancy J Sullivan; Daniel C Douek; Peter D Kwong; Barney S Graham; Jason S McLellan; John R Mascola. "Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses." Immunity (2021).

Epitope: 32.4K Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: N63, I64, K65, E66, K68, C69, N70, G71, D200, L204, P205, N208, K209, S211, C212, E295
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.25

Epitope: 32.4K Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: N63, I64, K65, E66, K68, C69, N70, G71, D200, L204, P205, N208, K209, S211, C212, E295
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive-High

Epitope: 32.4K Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: N63, I64, K65, E66, K68, C69, N70, G71, D200, L204, P205, N208, K209, S211, C212, E295
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: 32.4K Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: N63, I64, K65, E66, K68, C69, N70, G71, D200, L204, P205, N208, K209, S211, C212, E295
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00039

Epitope: 32.4K Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: N63, I64, K65, E66, K68, C69, N70, G71, D200, L204, P205, N208, K209, S211, C212, E295
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1600000.0

Epitope: 01.4B Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: L171, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, D194, N197, D263, P265
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00567

Epitope: 01.4B Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: L171, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, D194, N197, D263, P265
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive-High

Epitope: 01.4B Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: L171, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, D194, N197, D263, P265
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: 01.4B Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: L171, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, D194, N197, D263, P265
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000056

Epitope: 01.4B Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: L171, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, D194, N197, D263, P265
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 9800000.0

Epitope: ADI-14442 Fab epitope on RSV pre-F
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, L172, S173, T174, N175, K176, V178, S180, S186, L188, K191, V192, L193, D194, N197, Y198, Q202, N262, D263, P265, K271
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0076

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.913

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0503

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00687

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0073

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00642

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0706

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0291

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.124

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.017

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0855

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0751

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive-High

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0234

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.27

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00654

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00369

Epitope: Site Ø Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0435

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.35

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0567

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0754

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.11

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.87

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0821

Epitope: Site II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.08

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.25

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0871

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00444

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.05

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.736

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00262

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00133

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00696

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00101

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.261

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 32.4

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.66

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.162

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0105

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.89

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.25

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.99

Epitope: Site IV Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: R429, K433, S436, D440
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.67

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 16.0

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.75

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0362

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00464

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.598

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive-High

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00632

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0147

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0615

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0744

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0106

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0058

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0244

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0321

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0604

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.552

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00802

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 23.7

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.36

Epitope: Site V Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: S169, S173, V178
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.613

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.199

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0489

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.88

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 17.7

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.411

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 21.6

Epitope: I206, Q209
Chemical type: Discontinuous protein residues
Discontinuous residues: I206, Q209
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.354

Epitope: L172, S173
Chemical type: Discontinuous protein residues
Discontinuous residues: L172, S173
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.261

Epitope: L172, S173
Chemical type: Discontinuous protein residues
Discontinuous residues: L172, S173
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00351

Epitope: L172, S173
Chemical type: Discontinuous protein residues
Discontinuous residues: L172, S173
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.64

Epitope: L172, S173
Chemical type: Discontinuous protein residues
Discontinuous residues: L172, S173
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0126

Epitope: L172, S173
Chemical type: Discontinuous protein residues
Discontinuous residues: L172, S173
Source molecule (GenBank): AOZ56960.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0428

Epitope: Site Ø/II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211, N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 35.6

Epitope: Site Ø/II Patch
Chemical type: Discontinuous protein residues
Discontinuous residues: K65, N67, P205, V207, K209, S211, N268, K272
Source molecule (GenBank): P03420.1
Assay category: BCell
Result: Positive
Quantitative measurement: 19.2