Reference: L J Blumberg; J E Humphries; S D Jones; L B Pearce; R Holgate; A Hearn; J Cheung; A Mahmood; B Del Tito; J S Graydon; L E Stolz; A Bitonti; S Purohit; D de Graaf; K Kacena; J T Andersen; G J Christianson; D C Roopenian; J J Hubbard; A K Gandhi; K Lasseter; M Pyzik; R S Blumberg. "Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses." Science advances (2019).

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000293

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 47000.0

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00056

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 11.9

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.381

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.19

Epitope: Epitope of SYNT001 Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K108, G109, P110, L135, N136, E138, E139, D153, W154, P155, E156; B: I21, Q22, R23, D79
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 35600.0