Reference: Seth J Zost; Naveenchandra Suryadevara; Lauren E Williamson; Suzanne M Scheaffer; Elad Binshtein; Cameron D Buchman; Nicole V Johnson; Nicholas J Catanzaro; Silvia Ravera; Nathaniel S Chapman; Luke Myers; Ajit R Ramamohan; Laura S Handal; Doan C Nguyen; Andrew Trivette; James R Martinez; Eduardo Villalobos; Stacey A Rutherford; F Eun-Hyung Lee; Alexandra Schäfer; Ralph S Baric; Jason S McLellan; Michael S Diamond; Robert H Carnahan; James E Crowe. "Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants." Nature microbiology (2026).

Epitope: Epitope of Fab COV2-3835 on Omicron BA.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, F344, A345, S346, Y348, A349, L438, D439, S440, K441, S443, N445, Y446, N447, Y448, L449, R463, I465, F487, L489
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3891 on Omicron BQ.1.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N434, K435, V440, R493, P494, T495, Y496, G497, V498, Q501
Source molecule (GenBank): WCI16184.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.68
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Low
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Low
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of Fab COV2-3906 on Omicron XBB.1.5 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D360, S362, Y365, N366, A368, P369, F370, F371, A372, F373, K374, C375, S379, P380, T381, N384, I430, P523, K524
Source molecule (GenBank): WBW01504.1
Assay category: BCell
Result: Positive-Low
Host: F 28 years

Epitope: Epitope of mAb LY-CoV1404
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, S443, K444, V445, G446, G447, N450, Q498, P499, T500, N501, G502, Q506
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: M 33 years

Epitope: Epitope of mAb LY-CoV1404
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, S443, K444, V445, G446, G447, N450, Q498, P499, T500, N501, G502, Q506
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of mAb LY-CoV1404
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, S443, K444, V445, G446, G447, N450, Q498, P499, T500, N501, G502, Q506
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: M 38 years

Epitope: Epitope of mAb LY-CoV1404
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, S443, K444, V445, G446, G447, N450, Q498, P499, T500, N501, G502, Q506
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host:  35 years

Epitope: Epitope of mAb LY-CoV1404
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, S443, K444, V445, G446, G447, N450, Q498, P499, T500, N501, G502, Q506
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host:  35 years

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive
Host: M 38 years

Epitope: Epitope of mAb S309
Chemical type: Discontinuous protein residues
Discontinuous residues: N331, L332, P334, D336, E337, N340, A341, T342, R343, K353, S356, C358, L438, R506
Source molecule (GenBank): UJK14488.1
Assay category: BCell
Result: Positive
Host: M 33 years

Epitope: Epitope of mAb CR3022
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, K386, L390, F392, D428, T430, L517
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CR3022
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, K386, L390, F392, D428, T430, L517
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CR3022
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, K386, L390, F392, D428, T430, L517
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of mAb CR3022
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, K386, L390, F392, D428, T430, L517
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: F 28 years

Epitope: Epitope of mAb CR3022
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, K386, L390, F392, D428, T430, L517
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Host: M 33 years