Reference: M Y Hardy; L M Henneken; A K Russell; Y Okura; A Mizoroki; Y Ozono; S Kobayashi; Y Murakami; J A Tye-Din. "A bispecific antibody targeting HLA-DQ2.5-gluten peptides potently blocks gluten-specific T cells induced by gluten ingestion in patients with celiac disease." Clinical immunology (Orlando, Fla.) (2024).

Epitope: HLADQ2.5: 33mer gliadin
Chemical type: Peptide, no natural source
Sequence: LQLQPFPQPELPYPQPELPYPQPELPYPQPQPF
Assay category: BCell
Result: Positive

Epitope: HLADQ2.5: 33mer gliadin
Chemical type: Peptide, no natural source
Sequence: LQLQPFPQPELPYPQPELPYPQPELPYPQPQPF
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Gliadin - α-gliadin peptide 1
Chemical type: Peptide, no natural source
Sequence: LQPFPQPELPYPQPQ
Assay category: BCell
Result: Positive

Epitope: Gliadin - α-gliadin peptide 1
Chemical type: Peptide, no natural source
Sequence: LQPFPQPELPYPQPQ
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Gliadin - ω-gliadin peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPWQP
Assay category: BCell
Result: Positive

Epitope: Gliadin - ω-gliadin peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPWQP
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Hordein - Hor3a peptide 1
Chemical type: Peptide, no natural source
Sequence: PEQPIPEQPQPYPQQ
Assay category: BCell
Result: Positive

Epitope: Hordein - Hor3a peptide 1
Chemical type: Peptide, no natural source
Sequence: PEQPIPEQPQPYPQQ
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Hordein - Hor3b peptide 1
Chemical type: Peptide, no natural source
Sequence: QPQPYPEQPQPYP
Assay category: BCell
Result: Positive

Epitope: Hordein - Hor3b peptide 1
Chemical type: Peptide, no natural source
Sequence: QPQPYPEQPQPYP
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Hordein - Barley 03 petide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPWQP
Assay category: BCell
Result: Positive

Epitope: Hordein - Barley 03 petide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPWQP
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Secalin - Sec1/Sec2 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPQS
Assay category: BCell
Result: Positive

Epitope: Secalin - Sec1/Sec2 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPFPQS
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Secalin - Sec3 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPEQPEQIIPQQP
Assay category: BCell
Result: Positive-Low

Epitope: Secalin - Sec3 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPEQPEQIIPQQP
Assay category: TCell
Result: Positive-Low
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Secalin - Rye 01 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPIPQQ
Assay category: BCell
Result: Positive

Epitope: Secalin - Rye 01 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPIPQQ
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Secalin - Rye 03 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPTPIQ
Assay category: BCell
Result: Positive

Epitope: Secalin - Rye 03 peptide 1
Chemical type: Peptide, no natural source
Sequence: QPFPQPEQPTPIQ
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo