Reference: Aline Desmyter; Silvia Spinelli; Carlo Boutton; Michael Saunders; Christophe Blachetot; Hans de Haard; Geertrui Denecker; Maarten Van Roy; Christian Cambillau; Heidi Rommelaere. "Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex." Frontiers in immunology (2017).

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.3

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 100000.0

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00033

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.55

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobdy 124C4 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: P79, Q80, R83, H182, T186; D: N135, Y136, S137, R139, Q194, P200, K239, E257, D260, T261, W262, S263, T264, P265, H266, F269
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Negative

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 320000.0

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00018

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.55

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.6

Epitope: Epitope of nanobdy 37D5 on IL23
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K39, L43, W45, S46, A47, H48, P49, P113, S114, L115, L116, P117, D118, S119, P120, Q123, L159, R162, F163; D: D287, R288, F290, R309
Source molecule (GenBank): Q9NPF7.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 22E11 on IL23
Chemical type: Discontinuous protein residues
Discontinuous residues: W37, P39, D40, D63, E81, F82, G83, A85, K106, E108, D115, T147, I148, H216, K217, L218, K219
Source molecule (GenBank): P29460.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00023

Epitope: Epitope of nanobody 22E11 on IL23
Chemical type: Discontinuous protein residues
Discontinuous residues: W37, P39, D40, D63, E81, F82, G83, A85, K106, E108, D115, T147, I148, H216, K217, L218, K219
Source molecule (GenBank): P29460.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.55

Epitope: Epitope of nanobody 22E11 on IL23
Chemical type: Discontinuous protein residues
Discontinuous residues: W37, P39, D40, D63, E81, F82, G83, A85, K106, E108, D115, T147, I148, H216, K217, L218, K219
Source molecule (GenBank): P29460.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 22E11 on IL23
Chemical type: Discontinuous protein residues
Discontinuous residues: W37, P39, D40, D63, E81, F82, G83, A85, K106, E108, D115, T147, I148, H216, K217, L218, K219
Source molecule (GenBank): P29460.1
Assay category: BCell
Result: Positive