Reference: Paul E Harris; Scott Burkholz; Charles V Herst; Reid M Rubsamen. "Bioinformatic, Biochemical, and Immunological Mining of MHC Class I Restricted T Cell Epitopes for a Marburg Nucleoprotein Microparticle Vaccine." Vaccines (2024).

Epitope: Epitope 1
Chemical type: Peptide from protein
Sequence: APFARVLNL
Position: 276-284
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 1
Chemical type: Peptide from protein
Sequence: APFARVLNL
Position: 276-284
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 67.0

Epitope: Epitope 1
Chemical type: Peptide from protein
Sequence: APFARVLNL
Position: 276-284
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 1
Chemical type: Peptide from protein
Sequence: APFARVLNL
Position: 276-284
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.21

Epitope: Epitope 3
Chemical type: Peptide from protein
Sequence: APQEDTRAR
Position: 605-613
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 4
Chemical type: Peptide from protein
Sequence: DPFALLNED
Position: 461-469
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 5
Chemical type: Peptide from protein
Sequence: DPFGSIGDV
Position: 581-589
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 6
Chemical type: Peptide from protein
Sequence: DPIQHPAVS
Position: 570-578
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 7
Chemical type: Peptide from protein
Sequence: DPTPVEVTV
Position: 415-423
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Epitope 8
Chemical type: Peptide from protein
Sequence: EPHYSPLIL
Position: 106-114
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Epitope 9
Chemical type: Peptide from protein
Sequence: EPIRSPSSP
Position: 595-603
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive-Low
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 9
Chemical type: Peptide from protein
Sequence: EPIRSPSSP
Position: 595-603
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 10
Chemical type: Peptide from protein
Sequence: EPPRQSQDI
Position: 492-500
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 10
Chemical type: Peptide from protein
Sequence: EPPRQSQDI
Position: 492-500
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 12
Chemical type: Peptide from protein
Sequence: HPLVRTSKV
Position: 247-255
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 12
Chemical type: Peptide from protein
Sequence: HPLVRTSKV
Position: 247-255
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive

Epitope: Epitope 12
Chemical type: Peptide from protein
Sequence: HPLVRTSKV
Position: 247-255
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive

Epitope: Epitope 14
Chemical type: Peptide from protein
Sequence: IPNEPHYSP
Position: 103-111
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 15
Chemical type: Peptide from protein
Sequence: IPSTTSREF
Position: 479-487
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 16
Chemical type: Peptide from protein
Sequence: KPFLRYQEL
Position: 517-525
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 17
Chemical type: Peptide from protein
Sequence: KPTAPHVRN
Position: 12-20
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 18
Chemical type: Peptide from protein
Sequence: LPKLVVGDR
Position: 140-148
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 19
Chemical type: Peptide from protein
Sequence: LPPPPLYAQ
Position: 557-565
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 19
Chemical type: Peptide from protein
Sequence: LPPPPLYAQ
Position: 557-565
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 21
Chemical type: Peptide from protein
Sequence: LPPVQEDDE
Position: 525-533
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 21
Chemical type: Peptide from protein
Sequence: LPPVQEDDE
Position: 525-533
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 22
Chemical type: Peptide from protein
Sequence: NPPESLITA
Position: 654-662
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 24
Chemical type: Peptide from protein
Sequence: PPESLITAL
Position: 655-663
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 24
Chemical type: Peptide from protein
Sequence: PPESLITAL
Position: 655-663
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 25
Chemical type: Peptide from protein
Sequence: PPLYAQEKR
Position: 560-568
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 26
Chemical type: Peptide from protein
Sequence: PPPLYAQEK
Position: 559-567
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 27
Chemical type: Peptide from protein
Sequence: PPPPLYAQE
Position: 558-566
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 28
Chemical type: Peptide from protein
Sequence: PPPVDSKIE
Position: 435-443
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 29
Chemical type: Peptide from protein
Sequence: PPRQSQDID
Position: 493-501
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 30
Chemical type: Peptide from protein
Sequence: PPVDSKIEH
Position: 436-444
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 31
Chemical type: Peptide from protein
Sequence: PPVQEDDES
Position: 526-534
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 32
Chemical type: Peptide from protein
Sequence: QPGSDNEQG
Position: 546-554
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 33
Chemical type: Peptide from protein
Sequence: RPINRPTAL
Position: 426-434
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 34
Chemical type: Peptide from protein
Sequence: RPTALPPPV
Position: 430-438
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 34
Chemical type: Peptide from protein
Sequence: RPTALPPPV
Position: 430-438
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 35
Chemical type: Peptide from protein
Sequence: SPDFTNYED
Position: 619-627
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 35
Chemical type: Peptide from protein
Sequence: SPDFTNYED
Position: 619-627
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 36
Chemical type: Peptide from protein
Sequence: SPIAKYLRD
Position: 75-83
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 37
Chemical type: Peptide from protein
Sequence: SPLILALKT
Position: 110-118
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 38
Chemical type: Peptide from protein
Sequence: SPSAPQEDT
Position: 602-610
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 39
Chemical type: Peptide from protein
Sequence: SPSSPSAPQ
Position: 599-607
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 40
Chemical type: Peptide from protein
Sequence: TPVEVTVQA
Position: 417-425
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 40
Chemical type: Peptide from protein
Sequence: TPVEVTVQA
Position: 417-425
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 41
Chemical type: Peptide from protein
Sequence: WPDMSFDER
Position: 680-688
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 42
Chemical type: Peptide from protein
Sequence: WPQRVVTKK
Position: 632-640
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 43
Chemical type: Peptide from protein
Sequence: YPNDLLQTN
Position: 646-654
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 43
Chemical type: Peptide from protein
Sequence: YPNDLLQTN
Position: 646-654
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 44
Chemical type: Peptide from protein
Sequence: YPNHWLTTG
Position: 169-177
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 45
Chemical type: Peptide from protein
Sequence: YPQLSAIAL
Position: 295-303
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 45
Chemical type: Peptide from protein
Sequence: YPQLSAIAL
Position: 295-303
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 44.0

Epitope: Epitope 45
Chemical type: Peptide from protein
Sequence: YPQLSAIAL
Position: 295-303
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 17.0

Epitope: Epitope 46
Chemical type: Peptide from protein
Sequence: EVASFKQAL
Position: 258-266
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 86.0

Epitope: Epitope 46
Chemical type: Peptide from protein
Sequence: EVASFKQAL
Position: 258-266
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 46
Chemical type: Peptide from protein
Sequence: EVASFKQAL
Position: 258-266
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.7

Epitope: Epitope 46
Chemical type: Peptide from protein
Sequence: EVASFKQAL
Position: 258-266
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 250.0

Epitope: Epitope 47
Chemical type: Peptide from protein
Sequence: GEYAPFARV
Position: 273-281
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 47
Chemical type: Peptide from protein
Sequence: GEYAPFARV
Position: 273-281
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 107.0

Epitope: Epitope 47
Chemical type: Peptide from protein
Sequence: GEYAPFARV
Position: 273-281
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 214.0

Epitope: Epitope 48
Chemical type: Peptide from protein
Sequence: GLYPQLSAI
Position: 293-301
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Negative

Epitope: Epitope 48
Chemical type: Peptide from protein
Sequence: GLYPQLSAI
Position: 293-301
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 6.9

Epitope: Epitope 48
Chemical type: Peptide from protein
Sequence: GLYPQLSAI
Position: 293-301
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 5.9

Epitope: Epitope 48
Chemical type: Peptide from protein
Sequence: GLYPQLSAI
Position: 293-301
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.4

Epitope: Epitope 49
Chemical type: Peptide from protein
Sequence: HYSPLILAL
Position: 108-116
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 49
Chemical type: Peptide from protein
Sequence: HYSPLILAL
Position: 108-116
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 49
Chemical type: Peptide from protein
Sequence: HYSPLILAL
Position: 108-116
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 64.0

Epitope: Epitope 50
Chemical type: Peptide from protein
Sequence: KVKNEVASF
Position: 254-262
Source molecule (GenBank): ABE27012.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Epitope 50
Chemical type: Peptide from protein
Sequence: KVKNEVASF
Position: 254-262
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 50
Chemical type: Peptide from protein
Sequence: KVKNEVASF
Position: 254-262
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 5.6

Epitope: Epitope 50
Chemical type: Peptide from protein
Sequence: KVKNEVASF
Position: 254-262
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.9

Epitope: Epitope 50
Chemical type: Peptide from protein
Sequence: KVKNEVASF
Position: 254-262
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 158.0

Epitope: Epitope 51
Chemical type: Peptide from protein
Sequence: LEHGLYPQL
Position: 290-298
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.4

Epitope: Epitope 51
Chemical type: Peptide from protein
Sequence: LEHGLYPQL
Position: 290-298
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 51
Chemical type: Peptide from protein
Sequence: LEHGLYPQL
Position: 290-298
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14.0

Epitope: Epitope 52
Chemical type: Peptide from protein
Sequence: LIVKTVLEF
Position: 227-235
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Epitope 52
Chemical type: Peptide from protein
Sequence: LIVKTVLEF
Position: 227-235
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.8

Epitope: Epitope 52
Chemical type: Peptide from protein
Sequence: LIVKTVLEF
Position: 227-235
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 109.0

Epitope: Epitope 54
Chemical type: Peptide from protein
Sequence: TRFSGLLIV
Position: 221-229
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive

Epitope: Epitope 54
Chemical type: Peptide from protein
Sequence: TRFSGLLIV
Position: 221-229
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 55
Chemical type: Peptide from protein
Sequence: TVLEFILQK
Position: 231-239
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Negative

Epitope: Epitope 55
Chemical type: Peptide from protein
Sequence: TVLEFILQK
Position: 231-239
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 19.0

Epitope: Epitope 55
Chemical type: Peptide from protein
Sequence: TVLEFILQK
Position: 231-239
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.2

Epitope: Epitope 55
Chemical type: Peptide from protein
Sequence: TVLEFILQK
Position: 231-239
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.2

Epitope: Epitope 55
Chemical type: Peptide from protein
Sequence: TVLEFILQK
Position: 231-239
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 365.0

Epitope: Epitope 56
Chemical type: Peptide from protein
Sequence: VGQTRFSGL
Position: 218-226
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Epitope 56
Chemical type: Peptide from protein
Sequence: VGQTRFSGL
Position: 218-226
Source molecule (GenBank): ABE27012.1
Assay category: MhcBinding
Result: Positive