Reference: I-Ting Chow; Eddie A James; Theresa J Gates; Venus Tan; Antonis K Moustakas; George K Papadopoulos; William W Kwok. "Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk." Journal of immunology (Baltimore, Md. : 1950) (2013).

Epitope: H1MP 89-108
Chemical type: Peptide from protein
Sequence: DPNNMDKAVKLYRKLKREIT
Position: 89-108
Source molecule (GenBank): ABO21712.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1MP 89-108
Chemical type: Peptide from protein
Sequence: DPNNMDKAVKLYRKLKREIT
Position: 89-108
Source molecule (GenBank): ABO21712.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1MP 97-116
Chemical type: Peptide from protein
Sequence: VKLYRKLKREITFHGAKEIS
Position: 97-116
Source molecule (GenBank): ABO21712.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1MP 97-116
Chemical type: Peptide from protein
Sequence: VKLYRKLKREITFHGAKEIS
Position: 97-116
Source molecule (GenBank): ABO21712.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1MP 98-110 (WT)
Chemical type: Peptide from protein
Sequence: KLYRKLKREITFH
Position: 98-110
Source molecule (GenBank): ABO21712.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1800.0

Epitope: KLFRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLFRKLKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLWRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLWRKLKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLLRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLLRKLKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLIRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLIRKLKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLVRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLVRKLKREITFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLRRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLRRKLKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLKRKLKREITFH
Chemical type: Peptide, no natural source
Sequence: KLKRKLKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKMKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKMKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKEKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKEKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKQKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKQKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKAKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKAKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKPKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKPKREITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKYKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKYKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKKKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKKKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKRKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKRKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKHKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKHKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKDKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKDKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKSKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKSKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKFKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKFKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKTKREITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKTKREITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKKEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKKEITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKYEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKYEITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKHEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKHEITFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKSEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKSEITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKPEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKPEITFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKMEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKMEITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKLEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKLEITFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKVEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKVEITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKEEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKEEITFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKDEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKDEITFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKNEITFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKNEITFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKREINFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREINFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIDFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIDFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIEFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIEFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIQFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIQFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIMFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIMFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIAFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIAFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREILFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREILFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIYFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIYFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIVFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIVFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKREIKFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIKFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKREIHFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKREIHFH
Assay category: MhcBinding
Result: Positive

Epitope: H1HA 126-142
Chemical type: Peptide from protein
Sequence: SSFERFEIFPKESSWPN
Position: 126-142
Source molecule (GenBank): CAC86622.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 126-142
Chemical type: Peptide from protein
Sequence: SSFERFEIFPKESSWPN
Position: 126-142
Source molecule (GenBank): CAC86622.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 238-254
Chemical type: Peptide from protein
Sequence: DQEGRINYYWTLLEPGD
Position: 238-254
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 316-332
Chemical type: Peptide from protein
Sequence: IGECPKYVRSAKLRMVT
Position: 316-332
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 316-332
Chemical type: Peptide from protein
Sequence: IGECPKYVRSAKLRMVT
Position: 316-332
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 322-338
Chemical type: Peptide from protein
Sequence: YVRSAKLRMVTGLRNIP
Position: 322-338
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 322-338
Chemical type: Peptide from protein
Sequence: YVRSAKLRMVTGLRNIP
Position: 322-338
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 334-350
Chemical type: Peptide from protein
Sequence: LRNIPSIQSRGLFGAIA
Position: 334-350
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 340-356
Chemical type: Peptide from protein
Sequence: IQSRGLFGAIAGFIEGG
Position: 340-356
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 398-414
Chemical type: Peptide from protein
Sequence: VIEKMNTQFTAVGKEFN
Position: 398-414
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 404-420
Chemical type: Peptide from protein
Sequence: TQFTAVGKEFNKLERRM
Position: 404-420
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1HA 410-426
Chemical type: Peptide from protein
Sequence: GKEFNKLERRMENLNKK
Position: 410-426
Source molecule (GenBank): ACD37430.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H3HA 225-244
Chemical type: Peptide from protein
Sequence: QQTVIPNIGSRPRIRNIPSR
Position: 226-245
Source molecule (GenBank): ABW80978.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1NP 337-356
Chemical type: Peptide from protein
Sequence: AFEDLRVLSFIKGTKVLPRG
Position: 337-356
Source molecule (GenBank): P03466.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1NP 353-372
Chemical type: Peptide from protein
Sequence: LPRGKLSTRGVQIASNENME
Position: 353-372
Source molecule (GenBank): P03466.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H1NP 409-428
Chemical type: Peptide from protein
Sequence: QPTFSVQRNLPFDRTTIMAA
Position: 409-428
Source molecule (GenBank): P03466.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TTL 25-44
Chemical type: Peptide from protein
Sequence: PYCKGLDIYYKAFKITDRIW
Position: 26-45
Source molecule (GenBank): AAK72964.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TTL 25-44
Chemical type: Peptide from protein
Sequence: PYCKGLDIYYKAFKITDRIW
Position: 26-45
Source molecule (GenBank): AAK72964.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TTL 321-340
Chemical type: Peptide from protein
Sequence: SYKQIYQQKYQFDKDSNGQY
Position: 321-340
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TT 1162-1181
Chemical type: Peptide from protein
Sequence: LNIYYRRLYNGLKFIIKRYT
Position: 1162-1181
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TT 1162-1181
Chemical type: Peptide from protein
Sequence: LNIYYRRLYNGLKFIIKRYT
Position: 1162-1181
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TT 1242-1261
Chemical type: Peptide from protein
Sequence: AVKLRDLKTYSVQLKLYDDK
Position: 1242-1261
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TT 1242-1261
Chemical type: Peptide from protein
Sequence: AVKLRDLKTYSVQLKLYDDK
Position: 1242-1261
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KLYRKLKSEIKFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKSEIKFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKSEIEFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKSEIEFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKSEIYFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKSEIYFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKKEIKFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKKEIKFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKKEIEFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKKEIEFH
Assay category: MhcBinding
Result: Positive

Epitope: KLYRKLKKEIYFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKKEIYFH
Assay category: MhcBinding
Result: Positive-Low

Epitope: KLYRKLKEEIKFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKEEIKFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKEEIEFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKEEIEFH
Assay category: MhcBinding
Result: Negative

Epitope: KLYRKLKEEIYFH
Chemical type: Peptide, no natural source
Sequence: KLYRKLKEEIYFH
Assay category: MhcBinding
Result: Negative

Epitope: E2 12-26
Chemical type: Peptide from protein
Sequence: VAPWAGLEARWTALQ
Position: 12-26
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 12-26
Chemical type: Peptide from protein
Sequence: VAPWAGLEARWTALQ
Position: 12-26
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 75-89
Chemical type: Peptide from protein
Sequence: LQLLGSPGRRYYSLP
Position: 75-89
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 75-89
Chemical type: Peptide from protein
Sequence: LQLLGSPGRRYYSLP
Position: 75-89
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 134-148
Chemical type: Peptide from protein
Sequence: TVGFESLEECYMAKI
Position: 134-148
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 134-148
Chemical type: Peptide from protein
Sequence: TVGFESLEECYMAKI
Position: 134-148
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 145-159
Chemical type: Peptide from protein
Sequence: MAKILVAEGTRDVPI
Position: 145-159
Source molecule (GenBank): EAW67174.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E2 145-159
Chemical type: Peptide from protein
Sequence: MAKILVAEGTRDVPI
Position: 145-159
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 145-159
Chemical type: Peptide from protein
Sequence: MAKILVAEGTRDVPI
Position: 145-159
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 219-233
Chemical type: Peptide from protein
Sequence: MQVLLPALSPTMTMG
Position: 219-233
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 219-233
Chemical type: Peptide from protein
Sequence: MQVLLPALSPTMTMG
Position: 219-233
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 243-257
Chemical type: Peptide from protein
Sequence: GEKLSEGDLLAEIET
Position: 243-257
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 243-257
Chemical type: Peptide from protein
Sequence: GEKLSEGDLLAEIET
Position: 243-257
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 249-263
Chemical type: Peptide from protein
Sequence: GDLLAEIETDKATIG
Position: 249-263
Source molecule (GenBank): EAW67174.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E2 249-263
Chemical type: Peptide from protein
Sequence: GDLLAEIETDKATIG
Position: 249-263
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 249-263
Chemical type: Peptide from protein
Sequence: GDLLAEIETDKATIG
Position: 249-263
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 417-431
Chemical type: Peptide from protein
Sequence: TGVFTDIPISNIRRV
Position: 417-431
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 417-431
Chemical type: Peptide from protein
Sequence: TGVFTDIPISNIRRV
Position: 417-431
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 422-436
Chemical type: Peptide from protein
Sequence: DIPISNIRRVIAQRL
Position: 422-436
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 422-436
Chemical type: Peptide from protein
Sequence: DIPISNIRRVIAQRL
Position: 422-436
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 573-587
Chemical type: Peptide from protein
Sequence: IKNFSAIINPPQACI
Position: 573-587
Source molecule (GenBank): EAW67174.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E2 573-587
Chemical type: Peptide from protein
Sequence: IKNFSAIINPPQACI
Position: 573-587
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 573-587
Chemical type: Peptide from protein
Sequence: IKNFSAIINPPQACI
Position: 573-587
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Negative

Epitope: E2 629-643
Chemical type: Peptide from protein
Sequence: AQWLAEFRKYLEKPI
Position: 629-643
Source molecule (GenBank): EAW67174.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E2 629-643
Chemical type: Peptide from protein
Sequence: AQWLAEFRKYLEKPI
Position: 629-643
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive

Epitope: E2 629-643
Chemical type: Peptide from protein
Sequence: AQWLAEFRKYLEKPI
Position: 629-643
Source molecule (GenBank): EAW67174.1
Assay category: MhcBinding
Result: Positive