Reference: Pushpak Bhattacharjee; Miha Pakusch; Matthew Lacorcia; Eleonora Tresoldi; Alan F Rubin; Abby Foster; Laura King; Chris Y Chiu; Thomas W H Kay; John A Karas; Fergus J Cameron; Stuart I Mannering. "Proinsulin C-peptide is a major source of HLA-DQ8 restricted hybrid insulin peptides recognized by human islet-infiltrating CD4<sup>+</sup> T cells." PNAS nexus (2024).

Epitope: HIP-A
Chemical type: Spliced peptide from proteins
Position: 63-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-B
Chemical type: Spliced peptide from proteins
Position: 63-72
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-B
Chemical type: Spliced peptide from proteins
Position: 63-72
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-B
Chemical type: Spliced peptide from proteins
Position: 63-72
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-C
Chemical type: Spliced peptide from proteins
Position: 63-72
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-F
Chemical type: Spliced peptide from proteins
Position: 66-73
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-F
Chemical type: Spliced peptide from proteins
Position: 66-73
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-F
Chemical type: Spliced peptide from proteins
Position: 66-73
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-G
Chemical type: Spliced peptide from proteins
Position: 66-74
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-G
Chemical type: Spliced peptide from proteins
Position: 66-74
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-G
Chemical type: Spliced peptide from proteins
Position: 66-74
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-H
Chemical type: Spliced peptide from proteins
Position: 64-74
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-J
Chemical type: Spliced peptide from proteins
Position: 78-84
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-J
Chemical type: Spliced peptide from proteins
Position: 78-84
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-J
Chemical type: Spliced peptide from proteins
Position: 78-84
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-K
Chemical type: Spliced peptide from proteins
Position: 56-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-L
Chemical type: Spliced peptide from proteins
Position: 57-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-L
Chemical type: Spliced peptide from proteins
Position: 57-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-L
Chemical type: Spliced peptide from proteins
Position: 57-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-M
Chemical type: Spliced peptide from proteins
Position: 55-65
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: HIP-6
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PPI Pep# 11
Chemical type: Peptide from protein
Sequence: LQVGQVELGGGPGAGSLQ
Position: 61-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered