Reference: Chingwei V Lee; Hector Viadiu; Apurva Kalamkar; David I Bernstein; Andrew Pae; Xinchao Yu; Sylvia Wong; Fernando J Bravo; Sheng Ding; Elbert Seto; Magdeleine Hung; Yu Yu; Weimei Xing; Giuseppe A Papalia; Wei Kan; Brian Carr; Majlinda Thomas; Leah Tong; Priyanka Desai; Nadine Jarrousse; Alexandre Mercier; Meghan M Holdorf; Simon P Fletcher; Emma Abernathy. "Identification and engineering of potent bispecific antibodies that protect against herpes simplex virus recurrent disease." Cell reports (2025).

Epitope: Epitope of VHH C6 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: F189, E190, I193, D194, Y296, Y298, R299, H303, K315, Q316, V317, D318, G319
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of VHH C6 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: F189, E190, I193, D194, Y296, Y298, R299, H303, K315, Q316, V317, D318, G319
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH C6 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: F189, E190, I193, D194, Y296, Y298, R299, H303, K315, Q316, V317, D318, G319
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH C6 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: F189, E190, I193, D194, Y296, Y298, R299, H303, K315, Q316, V317, D318, G319
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D1 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: P575, D576, N577, I579, V580, N582, S600, R602, D605, L609, F640, G641, G643, Y652, H654, Q655, L656, S657, D660
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.8

Epitope: Epitope of VHH D1 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: P575, D576, N577, I579, V580, N582, S600, R602, D605, L609, F640, G641, G643, Y652, H654, Q655, L656, S657, D660
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D1 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: P575, D576, N577, I579, V580, N582, S600, R602, D605, L609, F640, G641, G643, Y652, H654, Q655, L656, S657, D660
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D1 on HSV-2 gB
Chemical type: Discontinuous protein residues
Discontinuous residues: P575, D576, N577, I579, V580, N582, S600, R602, D605, L609, F640, G641, G643, Y652, H654, Q655, L656, S657, D660
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D7 on HSV-2 gD
Chemical type: Discontinuous protein residues
Discontinuous residues: L50, Q52, L53, R61, V62, Y63, Q157, L218, P219, L245, P246, R247, F248, I249, N252, T255, V256
Source molecule (GenBank): Q5ICU7
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D7 on HSV-2 gD
Chemical type: Discontinuous protein residues
Discontinuous residues: L50, Q52, L53, R61, V62, Y63, Q157, L218, P219, L245, P246, R247, F248, I249, N252, T255, V256
Source molecule (GenBank): Q5ICU7
Assay category: BCell
Result: Positive
Quantitative measurement: 2.5

Epitope: Epitope of VHH D7 on HSV-2 gD
Chemical type: Discontinuous protein residues
Discontinuous residues: L50, Q52, L53, R61, V62, Y63, Q157, L218, P219, L245, P246, R247, F248, I249, N252, T255, V256
Source molecule (GenBank): Q5ICU7
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH D7 on HSV-2 gD
Chemical type: Discontinuous protein residues
Discontinuous residues: L50, Q52, L53, R61, V62, Y63, Q157, L218, P219, L245, P246, R247, F248, I249, N252, T255, V256
Source molecule (GenBank): Q5ICU7
Assay category: BCell
Result: Positive

Epitope: Epitope of NabFab on VHH D7
Chemical type: Discontinuous protein residues
Discontinuous residues: G9, G10, L11, Q39, A40, P41, G42, R45, T90, V92, Y94, K111, G112, P114, T116, V117, S118
Source molecule (GenBank): 9MY8_A
Assay category: BCell
Result: Positive