Reference: Katarzyna Składanowska; Yehudi Bloch; Jamie Strand; Kerry F White; Jing Hua; Daniel Aldridge; Martin Welin; Derek T Logan; Arne Soete; Romain Merceron; Casey Murphy; Mathias Provost; J Fernando Bazan; Christopher A Hunter; Jonathan A Hill; Savvas N Savvides. "Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27." Cell reports (2022).

Epitope: Epitope of nanobody 5 on mIL-27 ß subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: S37, R38, D44, A63, P77, C78, L79, Q80, R81, R87, T89, D129, P150, A151, S152, W153, P154
Source molecule (GenBank): O35228.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.228

Epitope: Epitope of nanobody 5 on mIL-27 ß subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: S37, R38, D44, A63, P77, C78, L79, Q80, R81, R87, T89, D129, P150, A151, S152, W153, P154
Source molecule (GenBank): O35228.1
Assay category: BCell
Result: Positive
Quantitative measurement: 958000.0

Epitope: Epitope of nanobody 5 on mIL-27 ß subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: S37, R38, D44, A63, P77, C78, L79, Q80, R81, R87, T89, D129, P150, A151, S152, W153, P154
Source molecule (GenBank): O35228.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00213

Epitope: Epitope of nanobody 5 on mIL-27 ß subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: S37, R38, D44, A63, P77, C78, L79, Q80, R81, R87, T89, D129, P150, A151, S152, W153, P154
Source molecule (GenBank): O35228.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.18

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00386

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 510000.0

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00000197

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0374

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0809

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.43

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 318000.0

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000119

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2340000.0

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000189

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 55000.0

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000244

Epitope: Epitope of SRF388 Fab on IL-27 α subunit
Chemical type: Discontinuous protein residues
Discontinuous residues: R31, P33, Q37, L38, E42, E46, V49, S50, L53, K56, W138, L142, D143, D146, L147, R149, H150, R152, F153, L156, A157, G159, F160, N161, L162, E164
Source molecule (GenBank): Q8NEV9.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.2