Reference: Korawit Kanjana; Klemen Strle; Robert B Lochhead; Annalisa Pianta; Laura M Mateyka; Qi Wang; Sheila L Arvikar; David E Kling; Cameron A Deangelo; Lucy Curham; Alan G Barbour; Catherine E Costello; James J Moon; Allen C Steere. "Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis." The Journal of clinical investigation (2023).

Epitope: Talin-1 858-873
Chemical type: Peptide from protein
Sequence: SAAKILADATAKMVEA
Position: 858-873
Source molecule (GenBank): Q9Y490.3
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Talin-1 858-873
Chemical type: Peptide from protein
Sequence: SAAKILADATAKMVEA
Position: 858-873
Source molecule (GenBank): Q9Y490.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Fetuin B 20-35
Chemical type: Peptide from protein
Sequence: SPPQLALNPSALLSRG
Position: 20-35
Source molecule (GenBank): Q9UGM5.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fetuin B 20-35
Chemical type: Peptide from protein
Sequence: SPPQLALNPSALLSRG
Position: 20-35
Source molecule (GenBank): Q9UGM5.2
Assay category: MhcLigandElution
Result: Positive

Epitope: MHC class II antigen 92-106
Chemical type: Peptide from protein
Sequence: SQKDILEDERAAVDT
Position: 92-106
Source molecule (GenBank): CAD5895153.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MHC class II antigen 92-106
Chemical type: Peptide from protein
Sequence: SQKDILEDERAAVDT
Position: 92-106
Source molecule (GenBank): CAD5895153.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Ficolin-1
Chemical type: Peptide from protein
Sequence: GNHQFAKYSFKVADE
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Ficolin-1
Chemical type: Peptide from protein
Sequence: GNHQFAKYSFKVADE
Assay category: MhcLigandElution
Result: Positive

Epitope: ISLR 377-397
Chemical type: Peptide from protein
Sequence: QPSGPEDNVVIIYLSRAGNPE
Position: 377-397
Source molecule (GenBank): O14498.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ISLR 377-397
Chemical type: Peptide from protein
Sequence: QPSGPEDNVVIIYLSRAGNPE
Position: 377-397
Source molecule (GenBank): O14498.1
Assay category: MhcLigandElution
Result: Positive

Epitope: CD4 receptor 55-69
Chemical type: Peptide from protein
Sequence: NSNQIKILGNQGSFL
Position: 55-69
Source molecule (GenBank): P01730.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: CD4 receptor 55-69
Chemical type: Peptide from protein
Sequence: NSNQIKILGNQGSFL
Position: 55-69
Source molecule (GenBank): P01730.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin-1 2021-2044
Chemical type: Peptide from protein
Sequence: ITGYIIKYEKPGSPPREVVPRPRP
Position: 2021-2044
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2021-2044
Chemical type: Peptide from protein
Sequence: ITGYIIKYEKPGSPPREVVPRPRP
Position: 2021-2044
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: MHC class I antigen 145-159
Chemical type: Peptide from protein
Sequence: KDYIALNEDLRSWTA
Position: 145-159
Source molecule (GenBank): P01889.3
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MHC class I antigen 145-159
Chemical type: Peptide from protein
Sequence: KDYIALNEDLRSWTA
Position: 145-159
Source molecule (GenBank): P01889.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin-1 1402-1416
Chemical type: Peptide from protein
Sequence: VAELSISPSDNAVVL
Position: 1402-1416
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 1402-1416
Chemical type: Peptide from protein
Sequence: VAELSISPSDNAVVL
Position: 1402-1416
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 1402-1416
Chemical type: Peptide from protein
Sequence: VAELSISPSDNAVVL
Position: 1402-1416
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 1402-1416
Chemical type: Peptide from protein
Sequence: VAELSISPSDNAVVL
Position: 1402-1416
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: C3 complement 589-604
Chemical type: Peptide from protein
Sequence: HGARVVLVAVDKGVFV
Position: 589-604
Source molecule (GenBank): P01024.2
Assay category: MhcLigandElution
Result: Positive

Epitope: C3 complement 1049-1063
Chemical type: Peptide from protein
Sequence: IKKGYTQQLAFRQPS
Position: 1049-1063
Source molecule (GenBank): P01024.2
Assay category: MhcLigandElution
Result: Positive

Epitope: C3 complement 916-934
Chemical type: Peptide from protein
Sequence: VYHHFISDGVRKSLKVVPE
Position: 916-934
Source molecule (GenBank): P01024.2
Assay category: MhcLigandElution
Result: Positive

Epitope: C5 complement 1170-1185
Chemical type: Peptide from protein
Sequence: KADNFLLENTLPAQST
Position: 1170-1185
Source molecule (GenBank): P01031.4
Assay category: MhcLigandElution
Result: Positive

Epitope: C1q complement 221-245
Chemical type: Peptide from protein
Sequence: PKKGHIYQGSEADSVFSGFLIFPSA
Position: 221-245
Source molecule (GenBank): P02745.2
Assay category: MhcLigandElution
Result: Positive

Epitope: C9 complement 239-253
Chemical type: Peptide from protein
Sequence: ISLKFTPTETNKAEQ
Position: 239-253
Source molecule (GenBank): P02748.2
Assay category: MhcLigandElution
Result: Positive

Epitope: ApoH 143-159
Chemical type: Peptide from protein
Sequence: PPPSIPTFATLRVYKPS
Position: 143-159
Source molecule (GenBank): P02749.3
Assay category: MhcLigandElution
Result: Positive

Epitope: ORM1 40-54
Chemical type: Peptide from protein
Sequence: TGKWFYIASAFRNEE
Position: 40-54
Source molecule (GenBank): P02763.2
Assay category: MhcLigandElution
Result: Positive

Epitope: C4 complement
Chemical type: Peptide from protein
Sequence: RPVAFSVVPTAAAV
Assay category: MhcLigandElution
Result: Positive

Epitope: Filamin A 2445-2461
Chemical type: Peptide from protein
Sequence: GNPAEFVVNTSNAGAGA
Position: 2445-2461
Source molecule (GenBank): P21333.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Filamin A 1267-1282
Chemical type: Peptide from protein
Sequence: GQGVFREATTEFSVDA
Position: 1267-1282
Source molecule (GenBank): P21333.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Collagen Vα1
Chemical type: Peptide from protein
Sequence: FPEDFSLILTTAVKAKKG
Assay category: MhcLigandElution
Result: Positive

Epitope: Laminin B2 101-115
Chemical type: Peptide from protein
Sequence: HGAAFLTDYNNQADT
Position: 101-115
Source molecule (GenBank): P11047.3
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Laminin B2 101-115
Chemical type: Peptide from protein
Sequence: HGAAFLTDYNNQADT
Position: 101-115
Source molecule (GenBank): P11047.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Laminin B2 664-681
Chemical type: Peptide from protein
Sequence: SAGYLDDVTLASARPGPG
Position: 664-681
Source molecule (GenBank): P11047.3
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Laminin B2 664-681
Chemical type: Peptide from protein
Sequence: SAGYLDDVTLASARPGPG
Position: 664-681
Source molecule (GenBank): P11047.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Laminin B2 664-681
Chemical type: Peptide from protein
Sequence: SAGYLDDVTLASARPGPG
Position: 664-681
Source molecule (GenBank): P11047.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Laminin B2 664-681
Chemical type: Peptide from protein
Sequence: SAGYLDDVTLASARPGPG
Position: 664-681
Source molecule (GenBank): P11047.3
Assay category: MhcLigandElution
Result: Positive

Epitope: ITGAM
Chemical type: Peptide from protein
Sequence: TEKEFQNNPNPRSLVKP
Assay category: MhcLigandElution
Result: Positive

Epitope: Paxillin
Chemical type: Peptide from protein
Sequence: RPVELSEETPYSYPT
Assay category: MhcLigandElution
Result: Positive

Epitope: TIMP3 96-112
Chemical type: Peptide from protein
Sequence: EVNKYQYLLTGRVYDGK
Position: 96-112
Source molecule (GenBank): P35625.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TIMP3 96-112
Chemical type: Peptide from protein
Sequence: EVNKYQYLLTGRVYDGK
Position: 96-112
Source molecule (GenBank): P35625.2
Assay category: MhcLigandElution
Result: Positive

Epitope: HNRNPA1 342-356
Chemical type: Peptide from protein
Sequence: GGGGQYFAKPRNQGG
Position: 342-356
Source molecule (GenBank): P09651.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin-1 2019-2035
Chemical type: Peptide from protein
Sequence: ARITGYIIKYEKPGSPP
Position: 2019-2035
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2019-2035
Chemical type: Peptide from protein
Sequence: ARITGYIIKYEKPGSPP
Position: 2019-2035
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2019-2035
Chemical type: Peptide from protein
Sequence: ARITGYIIKYEKPGSPP
Position: 2019-2035
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2019-2035
Chemical type: Peptide from protein
Sequence: ARITGYIIKYEKPGSPP
Position: 2019-2035
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin-1 2015-2029
Chemical type: Peptide from protein
Sequence: QPPRARITGYIIKYE
Position: 2015-2029
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2015-2029
Chemical type: Peptide from protein
Sequence: QPPRARITGYIIKYE
Position: 2015-2029
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: synovial fluid
Culture conditions: Short Term Restimulated

Epitope: Fibronectin-1 2015-2029
Chemical type: Peptide from protein
Sequence: QPPRARITGYIIKYE
Position: 2015-2029
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2015-2029
Chemical type: Peptide from protein
Sequence: QPPRARITGYIIKYE
Position: 2015-2029
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin-1 2015-2029
Chemical type: Peptide from protein
Sequence: QPPRARITGYIIKYE
Position: 2015-2029
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Collagen Vα1 96-111
Chemical type: Peptide from protein
Sequence: FPEDFSILTTVKAKKG
Position: 96-111
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Collagen Vα1 96-111
Chemical type: Peptide from protein
Sequence: FPEDFSILTTVKAKKG
Position: 96-111
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Collagen Vα1 96-111
Chemical type: Peptide from protein
Sequence: FPEDFSILTTVKAKKG
Position: 96-111
Source molecule (GenBank): P20908.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin 1996-2014
Chemical type: Peptide from protein
Sequence: APSNLRFLATTPNSLLVSW
Position: 1996-2014
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin 1996-2014
Chemical type: Peptide from protein
Sequence: APSNLRFLATTPNSLLVSW
Position: 1996-2014
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin 1996-2014
Chemical type: Peptide from protein
Sequence: APSNLRFLATTPNSLLVSW
Position: 1996-2014
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin 2060-2076
Chemical type: Peptide from protein
Sequence: YTIYVIALKNNQKSEPL
Position: 2060-2076
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin 2060-2076
Chemical type: Peptide from protein
Sequence: YTIYVIALKNNQKSEPL
Position: 2060-2076
Source molecule (GenBank): P02751.5
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fibronectin 2060-2076
Chemical type: Peptide from protein
Sequence: YTIYVIALKNNQKSEPL
Position: 2060-2076
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Collagen Vα1 1730-1750
Chemical type: Peptide from protein
Sequence: GVVQMTFLRLLSASAHQNVTY
Position: 1724-1744
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: synovial fluid
Culture conditions: Short Term Restimulated

Epitope: Collagen Vα1 1730-1750
Chemical type: Peptide from protein
Sequence: GVVQMTFLRLLSASAHQNVTY
Position: 1724-1744
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Collagen Vα1 1730-1750
Chemical type: Peptide from protein
Sequence: GVVQMTFLRLLSASAHQNVTY
Position: 1724-1744
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Collagen Vα1 1730-1750
Chemical type: Peptide from protein
Sequence: GVVQMTFLRLLSASAHQNVTY
Position: 1724-1744
Source molecule (GenBank): P20908.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Collagen Vα1 1730-1750
Chemical type: Peptide from protein
Sequence: GVVQMTFLRLLSASAHQNVTY
Position: 1724-1744
Source molecule (GenBank): P20908.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Bb-93kD 101-125
Chemical type: Peptide from protein
Sequence: LDSILNLRRILTGYIIKSFD
Position: 106-125
Source molecule (GenBank): CAA49829.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb-93kD 101-125
Chemical type: Peptide from protein
Sequence: LDSILNLRRILTGYIIKSFD
Position: 106-125
Source molecule (GenBank): CAA49829.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: synovial fluid
Culture conditions: Short Term Restimulated

Epitope: Bb uncharacterized protein [CA8] 9-23
Chemical type: Peptide from protein
Sequence: IAILLISPSCSTNNN
Position: 9-23
Source molecule (GenBank): EOA80158.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb-transcriptional activator 163-177
Chemical type: Peptide from protein
Sequence: IKKFPISTPNSLLER
Position: 171-185
Source molecule (GenBank): WP_044273090.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb-exodeoxyribonuclease 334-351
Chemical type: Peptide from protein
Sequence: TIDQNYIISNLKNYLKSE
Position: 334-351
Source molecule (GenBank): WP_002665669.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb-93kD 694-708
Chemical type: Peptide from protein
Sequence: KNLVILDVNTLKKVK
Position: 694-708
Source molecule (GenBank): CAA49829.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb- DUF685 domain-containing protein180-194
Chemical type: Peptide from protein
Sequence: NMEYNDDVTLIFSKS
Position: 180-194
Source molecule (GenBank): WP_012663408.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb-hypothetical protein L144_03550 [CA382] 116-130
Chemical type: Peptide from protein
Sequence: DLDFSILSSDSLKAK
Position: 116-130
Source molecule (GenBank): WP_044273117.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bb- transcription elongation factor GreA 79-93
Chemical type: Peptide from protein
Sequence: QQFLTKRLNSLMLEI
Position: 796-810
Source molecule (GenBank): WP_106017300.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo