Reference: Siriruk Changrob; Atsuhiro Yasuhara; Suncheol Park; Sandhya Bangaru; Lei Li; Chloe A Troxell; Peter J Halfmann; Steven A Erickson; Nicholas J Catanzaro; Meng Yuan; Panpan Zhou; Min Huang; G Dewey Wilbanks; Joshua J C McGrath; Gagandeep Singh; Sean A Nelson; Yanbin Fu; Nai-Ying Zheng; Sofia M Carayannopoulos; Haley L Dugan; Dustin G Shaw; Christopher T Stamper; Maria Lucia L Madariaga; Florian Krammer; Raiees Andrabi; Dennis R Burton; Andrew B Ward; Ian A Wilson; Yoshihiro Kawaoka; Patrick C Wilson. "Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2." The Journal of experimental medicine (2025).

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 6.0

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.74

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R125-61 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Y756, F759, N969, F970, G971, I973, R983, L984, D985, E988, V991, Q992, R995, T998, G999, Q1002
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of NICA01A-1401 Fab on SARS-CoV-2 S2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q755, Y756, F759, Q762, Q965, F970, G971, E988, E990, V991, Q992, D994, R995, T998, Q1002, T1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive