Reference: Yang Wang; Tomasz Sosinowski; Andrey Novikov; Frances Crawford; Janice White; Niyun Jin; Zikou Liu; Jinhao Zou; David Neau; Howard W Davidson; Maki Nakayama; William W Kwok; Laurent Gapin; Philippa Marrack; John W Kappler; Shaodong Dai. "How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes." Science immunology (2019).

Epitope: B: 10-23 (p8E9E6ss)
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEEG
Assay category: TCell
Result: Positive
Quantitative measurement: 3.1
Host:  12-24 weeks

Epitope: B: 10-23 (p8E9E6ss)
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEEG
Assay category: TCell
Result: Positive
Host:  12-24 weeks
Cell type: T cell hybridoma
Tissue: lymphoid
Culture conditions: Engineered

Epitope: B: 10-23 (p8E9E6ss)
Chemical type: Peptide, no natural source
Sequence: HLVERLYLVCGEEG
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.1

Epitope: B: 11-23 (p8G9E)
Chemical type: Peptide, no natural source
Sequence: LVERLYLVCGGEG
Assay category: TCell
Result: Positive
Quantitative measurement: 3.2

Epitope: B: 11-23 (p8G9E)
Chemical type: Peptide, no natural source
Sequence: LVERLYLVCGGEG
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: B: 11-23 (p8G9E)
Chemical type: Peptide, no natural source
Sequence: LVERLYLVCGGEG
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.2

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Quantitative measurement: 2.03

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Quantitative measurement: 20500.0

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Quantitative measurement: 0.065

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: lymphoid
Culture conditions: Engineered

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: TCell
Result: Positive
Quantitative measurement: 3185.0

Epitope: B: 11-23 (p8E9E11ss)
Chemical type: Peptide, no natural source
Sequence: LVEELYLVAGEEGC
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.03

Epitope: VEALYLVAGEEVE
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEEVE
Assay category: TCell
Result: Positive-High
Host:  12-24 weeks
Cell type: T cell hybridoma
Tissue: lymphoid
Culture conditions: Engineered

Epitope: VEALYLVAGDLQ
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGDLQ
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell hybridoma
Tissue: lymphoid
Culture conditions: Engineered

Epitope: VEALYLVAGDLQ
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGDLQ
Assay category: TCell
Result: Positive-High
Cell type: T cell
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: VEALYLVAVEQL
Chemical type: Peptide, no natural source
Sequence: VEALYLVAVEQL
Assay category: TCell
Result: Positive-High
Host:  6-12 weeks
Cell type: T cell
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: VEALYLVALELG
Chemical type: Peptide, no natural source
Sequence: VEALYLVALELG
Assay category: TCell
Result: Positive-High
Host:  6-12 weeks
Cell type: T cell
Tissue: lymphoid
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: VEALYLVALELG
Chemical type: Peptide, no natural source
Sequence: VEALYLVALELG
Assay category: TCell
Result: Positive-Low
Host:  12-24 weeks
Cell type: T cell hybridoma
Tissue: lymphoid
Culture conditions: Engineered

Epitope: VEALYLVAGEEAE
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEEAE
Assay category: TCell
Result: Positive-High
Cell type: T cell CD4+
Tissue: lymphoid
Culture conditions: Engineered

Epitope: VEALYLVAGEELG
Chemical type: Peptide, no natural source
Sequence: VEALYLVAGEELG
Assay category: TCell
Result: Positive-High
Cell type: T cell CD4+
Tissue: lymphoid
Culture conditions: Engineered