Reference: Mathieu Gigoux; Morten O Holmström; Roberta Zappasodi; Joseph J Park; Stephane Pourpe; Cansu Cimen Bozkus; Levi M B Mangarin; David Redmond; Svena Verma; Sara Schad; Mariam M George; Divya Venkatesh; Arnab Ghosh; David Hoyos; Zaki Molvi; Baransel Kamaz; Anna E Marneth; William Duke; Matthew J Leventhal; Max Jan; Vincent T Ho; Gabriela S Hobbs; Trine Alma Knudsen; Vibe Skov; Lasse Kjær; Thomas Stauffer Larsen; Dennis Lund Hansen; R Coleman Lindsley; Hans Hasselbalch; Jacob H Grauslund; Thomas L Lisle; Özcan Met; Patrick Wilkinson; Benjamin Greenbaum; Manuel A Sepulveda; Timothy Chan; Raajit Rampal; Mads H Andersen; Omar Abdel-Wahab; Nina Bhardwaj; Jedd D Wolchok; Ann Mullally; Taha Merghoub. "Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine." Science translational medicine (2022).

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
MHC allele types: 251 252 1 3 311
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR Long36
Chemical type: Peptide, no natural source
Sequence: RMRRMRRTRRKMRRKMSPARPRTSCREACLQGWTEA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C-terminal mutant CALR neoepitope fragment
Chemical type: Peptide, no natural source
Sequence: RPRTSCREA
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C-terminal mutant CALR neoepitope fragment
Chemical type: Peptide, no natural source
Sequence: RPRTSCREA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Positive-Intermediate
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: MhcBinding
Result: Positive-Low

Epitope: CALR 9p2
Chemical type: Peptide, no natural source
Sequence: RMMRTKMRM
Assay category: MhcBinding
Result: Positive-Low

Epitope: CALR 9p2 K6F
Chemical type: Peptide, no natural source
Sequence: RMMRTFMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6F
Chemical type: Peptide, no natural source
Sequence: RMMRTFMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6F
Chemical type: Peptide, no natural source
Sequence: RMMRTFMRM
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: CALR 9p2 K6M
Chemical type: Peptide, no natural source
Sequence: RMMRTFMMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6M
Chemical type: Peptide, no natural source
Sequence: RMMRTFMMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6M
Chemical type: Peptide, no natural source
Sequence: RMMRTFMMRM
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: CALR 9p2 K6V
Chemical type: Peptide, no natural source
Sequence: RMMRTVMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6V
Chemical type: Peptide, no natural source
Sequence: RMMRTVMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 K6V
Chemical type: Peptide, no natural source
Sequence: RMMRTVMRM
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: CALR 9p2 R1Y
Chemical type: Peptide, no natural source
Sequence: YMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 R1Y
Chemical type: Peptide, no natural source
Sequence: YMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 R1Y
Chemical type: Peptide, no natural source
Sequence: YMMRTKMRM
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: CALR 9p2 R1F
Chemical type: Peptide, no natural source
Sequence: FMMRTKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 R1F
Chemical type: Peptide, no natural source
Sequence: FMMRTKMRM
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive-Intermediate
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymph node
Culture conditions: Short Term Restimulated

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: TCell
Result: Positive

Epitope: CALR 9p2 T5F
Chemical type: Peptide, no natural source
Sequence: RMMRFKMRM
Assay category: MhcBinding
Result: Positive-Intermediate