Reference: Heather K Kroh; Jaime L Jensen; Sabine Wellnitz; Jeong Jin Park; Alexandre Esadze; Kevin W Huynh; Mark Ammirati; Seungil Han; Annaliesa S Anderson; D Borden Lacy; Alexey Gribenko. "Mouse monoclonal antibodies against  toxins TcdA and TcdB target diverse epitopes for neutralization." Infection and immunity (2025).

Epitope: Epitope of Fab mCDIFA-184-9 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: L1069, A1070, I1071, N1072, M1073, S1074, L1075, S1076, I1077, A1078, A1079, T1080, V1081, A1082, S1083, I1084, V1085, G1086, I1087, G1088, A1089, E1090, Y1462, T1463, D1464, E1465, S1466, N1467, N1468, K1469, Y1470, F1471, G1472, A1473, I1474, S1475
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-184-9 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: L1069, A1070, I1071, N1072, M1073, S1074, L1075, S1076, I1077, A1078, A1079, T1080, V1081, A1082, S1083, I1084, V1085, G1086, I1087, G1088, A1089, E1090, Y1462, T1463, D1464, E1465, S1466, N1467, N1468, K1469, Y1470, F1471, G1472, A1473, I1474, S1475
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-184-9 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: L1069, A1070, I1071, N1072, M1073, S1074, L1075, S1076, I1077, A1078, A1079, T1080, V1081, A1082, S1083, I1084, V1085, G1086, I1087, G1088, A1089, E1090, Y1462, T1463, D1464, E1465, S1466, N1467, N1468, K1469, Y1470, F1471, G1472, A1473, I1474, S1475
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-184-9 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: L1069, A1070, I1071, N1072, M1073, S1074, L1075, S1076, I1077, A1078, A1079, T1080, V1081, A1082, S1083, I1084, V1085, G1086, I1087, G1088, A1089, E1090, Y1462, T1463, D1464, E1465, S1466, N1467, N1468, K1469, Y1470, F1471, G1472, A1473, I1474, S1475
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-184-9 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: L1069, A1070, I1071, N1072, M1073, S1074, L1075, S1076, I1077, A1078, A1079, T1080, V1081, A1082, S1083, I1084, V1085, G1086, I1087, G1088, A1089, E1090, Y1462, T1463, D1464, E1465, S1466, N1467, N1468, K1469, Y1470, F1471, G1472, A1473, I1474, S1475
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-205-7 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: V1109, N1110, N1111, E1112, L1113, I1114, S1329, S1330, Y1331, P1332, I1333, S1334, T1335, N1336, I1337, E1355, I1356, S1357, I1358, E1359
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-205-7 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: V1109, N1110, N1111, E1112, L1113, I1114, S1329, S1330, Y1331, P1332, I1333, S1334, T1335, N1336, I1337, E1355, I1356, S1357, I1358, E1359
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-205-7 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: V1109, N1110, N1111, E1112, L1113, I1114, S1329, S1330, Y1331, P1332, I1333, S1334, T1335, N1336, I1337, E1355, I1356, S1357, I1358, E1359
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-205-7 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: V1109, N1110, N1111, E1112, L1113, I1114, S1329, S1330, Y1331, P1332, I1333, S1334, T1335, N1336, I1337, E1355, I1356, S1357, I1358, E1359
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-Low
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-205-7 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: V1109, N1110, N1111, E1112, L1113, I1114, S1329, S1330, Y1331, P1332, I1333, S1334, T1335, N1336, I1337, E1355, I1356, S1357, I1358, E1359
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 38.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-High
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-248-25 on TXDA
Chemical type: Discontinuous protein residues
Discontinuous residues: S1130, K1133, K1134, A1207, G1209, I1210, E1211, N1247, D1248, R1251, S1255, D1258, L1259, A2176, N2177
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-230-2 on TXDA
Chemical type: Peptide from protein
Sequence: LRSLENDGTRLLD
Position: 1242-1254
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-230-2 on TXDA
Chemical type: Peptide from protein
Sequence: LRSLENDGTRLLD
Position: 1242-1254
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-230-2 on TXDA
Chemical type: Peptide from protein
Sequence: LRSLENDGTRLLD
Position: 1242-1254
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-230-2 on TXDA
Chemical type: Peptide from protein
Sequence: LRSLENDGTRLLD
Position: 1242-1254
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 90.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFA-230-2 on TXDA
Chemical type: Peptide from protein
Sequence: LRSLENDGTRLLD
Position: 1242-1254
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-6-30 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: L297, F298, E299, S300, I301, E302, K303, P304, S305, S306, V307, F346, E347, S348, V349, L350, A351, S352, K353, S354, D355, K356, S357, E358, I359, F360
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-6-30 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: L297, F298, E299, S300, I301, E302, K303, P304, S305, S306, V307, F346, E347, S348, V349, L350, A351, S352, K353, S354, D355, K356, S357, E358, I359, F360
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-6-30 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: L297, F298, E299, S300, I301, E302, K303, P304, S305, S306, V307, F346, E347, S348, V349, L350, A351, S352, K353, S354, D355, K356, S357, E358, I359, F360
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-6-30 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: L297, F298, E299, S300, I301, E302, K303, P304, S305, S306, V307, F346, E347, S348, V349, L350, A351, S352, K353, S354, D355, K356, S357, E358, I359, F360
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive-Intermediate
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-6-30 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: L297, F298, E299, S300, I301, E302, K303, P304, S305, S306, V307, F346, E347, S348, V349, L350, A351, S352, K353, S354, D355, K356, S357, E358, I359, F360
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-8-26 on TXDB
Chemical type: Peptide from protein
Sequence: RTQEDEYVAILDA
Position: 18-30
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-8-26 on TXDB
Chemical type: Peptide from protein
Sequence: RTQEDEYVAILDA
Position: 18-30
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-8-26 on TXDB
Chemical type: Peptide from protein
Sequence: RTQEDEYVAILDA
Position: 18-30
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-8-26 on TXDB
Chemical type: Peptide from protein
Sequence: RTQEDEYVAILDA
Position: 18-30
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-8-26 on TXDB
Chemical type: Peptide from protein
Sequence: RTQEDEYVAILDA
Position: 18-30
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.0
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-56-15 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: I1704, T1705, P1706, V1707, Y1708, N1730, V1731, N1732, I1733, N1734, D1735, L1736, S1737, I1738, R1739, Y1740, N1783, F1784, S1785, D1786, K1787, Q1788, D1789, V1790, P1791, V1792, S1793, E1794, I1795, I1796
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-56-15 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: I1704, T1705, P1706, V1707, Y1708, N1730, V1731, N1732, I1733, N1734, D1735, L1736, S1737, I1738, R1739, Y1740, N1783, F1784, S1785, D1786, K1787, Q1788, D1789, V1790, P1791, V1792, S1793, E1794, I1795, I1796
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-56-15 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: I1704, T1705, P1706, V1707, Y1708, N1730, V1731, N1732, I1733, N1734, D1735, L1736, S1737, I1738, R1739, Y1740, N1783, F1784, S1785, D1786, K1787, Q1788, D1789, V1790, P1791, V1792, S1793, E1794, I1795, I1796
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive-Intermediate
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-56-15 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: I1704, T1705, P1706, V1707, Y1708, N1730, V1731, N1732, I1733, N1734, D1735, L1736, S1737, I1738, R1739, Y1740, N1783, F1784, S1785, D1786, K1787, Q1788, D1789, V1790, P1791, V1792, S1793, E1794, I1795, I1796
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab mCDIFB-56-15 on TXDB
Chemical type: Discontinuous protein residues
Discontinuous residues: I1704, T1705, P1706, V1707, Y1708, N1730, V1731, N1732, I1733, N1734, D1735, L1736, S1737, I1738, R1739, Y1740, N1783, F1784, S1785, D1786, K1787, Q1788, D1789, V1790, P1791, V1792, S1793, E1794, I1795, I1796
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 38.0
Host: F 6-8 weeks