Reference: S V Antonyuk; C R Trevitt; R W Strange; G S Jackson; D Sangar; M Batchelor; S Cooper; C Fraser; S Jones; T Georgiou; A Khalili-Shirazi; A R Clarke; S S Hasnain; J Collinge. "Crystal structure of human prion protein bound to a therapeutic antibody." Proceedings of the National Academy of Sciences of the United States of America (2009).

Epitope: ICSM 18 Fab epitope on PrP
Chemical type: Discontinuous protein residues
Discontinuous residues: S143, D144, Y145, R148 R151, E152, K204
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive

Epitope: ICSM 18 Fab epitope on PrP
Chemical type: Discontinuous protein residues
Discontinuous residues: S143, D144, Y145, R148 R151, E152, K204
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-High
Quantitative measurement: 0.13

Epitope: ICSM 18 Fab epitope on PrP
Chemical type: Discontinuous protein residues
Discontinuous residues: S143, D144, Y145, R148 R151, E152, K204
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive

Epitope: ICSM 18 Fab epitope on PrP
Chemical type: Discontinuous protein residues
Discontinuous residues: S143, D144, Y145, R148 R151, E152, K204
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.9

Epitope: PrP 96-105
Chemical type: Peptide from protein
Sequence: HSQWNKPSKP
Position: 96-105
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Negative

Epitope: PrP 96-105
Chemical type: Peptide from protein
Sequence: HSQWNKPSKP
Position: 96-105
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 3300.0

Epitope: PrP 91-110
Chemical type: Peptide from protein
Sequence: QGGGTHSQWNKPSKPKTNMK
Position: 91-110
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 4600.0

Epitope: PrP 91-110
Chemical type: Peptide from protein
Sequence: QGGGTHSQWNKPSKPKTNMK
Position: 91-110
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Negative

Epitope: PrP 171-190
Chemical type: Peptide from protein
Sequence: NQNNFVHDCVNITIKQHTVT
Position: 171-190
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-Low

Epitope: PrP 171-190
Chemical type: Peptide from protein
Sequence: NQNNFVHDCVNITIKQHTVT
Position: 171-190
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Negative

Epitope: PrP 171-190
Chemical type: Peptide from protein
Sequence: NQNNFVHDCVNITIKQHTVT
Position: 171-190
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-High
Quantitative measurement: 0.54

Epitope: PrP 131-150
Chemical type: Peptide from protein
Sequence: GSAMSRPIIHFGSDYEDRYY
Position: 131-150
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Negative

Epitope: PrP 131-150
Chemical type: Peptide from protein
Sequence: GSAMSRPIIHFGSDYEDRYY
Position: 131-150
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-High
Quantitative measurement: 0.42

Epitope: PrP 131-150
Chemical type: Peptide from protein
Sequence: GSAMSRPIIHFGSDYEDRYY
Position: 131-150
Source molecule (GenBank): P04156.1
Assay category: BCell
Result: Positive-Low