Reference: Xiaojie Yu; H T Claude Chan; Christian M Orr; Osman Dadas; Steven G Booth; Lekh N Dahal; Christine A Penfold; Lyn O'Brien; C Ian Mockridge; Ruth R French; Patrick Duriez; Leon R Douglas; Arwen R Pearson; Mark S Cragg; Ivo Tews; Martin J Glennie; Ann L White. "Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies." Cancer cell (2018).

Epitope: Epitope of ChiLob7/4 Fab' on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: E21, P22, P23, R27, K29, Q30, S35, Q36, C37, S39, Q42, Q45, C51, T52, E53, F54, T55, E56, T57, C59, W71
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.99

Epitope: Epitope of ChiLob7/4 Fab' on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: E21, P22, P23, R27, K29, Q30, S35, Q36, C37, S39, Q42, Q45, C51, T52, E53, F54, T55, E56, T57, C59, W71
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of ChiLob7/4 Fab' on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: E21, P22, P23, R27, K29, Q30, S35, Q36, C37, S39, Q42, Q45, C51, T52, E53, F54, T55, E56, T57, C59, W71
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of ChiLob7/4 Fab' on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: E21, P22, P23, R27, K29, Q30, S35, Q36, C37, S39, Q42, Q45, C51, T52, E53, F54, T55, E56, T57, C59, W71
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of ChiLob7/4 Fab' on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: E21, P22, P23, R27, K29, Q30, S35, Q36, C37, S39, Q42, Q45, C51, T52, E53, F54, T55, E56, T57, C59, W71
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of CP870,893 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: R27, E28
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive
Host:  8-10 weeks

Epitope: Epitope of CP870,893 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: R27, E28
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive
Host:  8-10 weeks

Epitope: Epitope of CP870,893 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: R27, E28
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive
Host:  8-10 weeks

Epitope: Epitope of CP870,893 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: R27, E28
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive
Host:  8-10 weeks

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of SGN40 (dacetuzumab) and Lob 7/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: T52, E53, F54, T55, E56, T57
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 8/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: G63, E64, K94, G95
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 8/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: G63, E64, K94, G95
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 8/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: G63, E64, K94, G95
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Lob 8/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: G63, E64, K94, G95
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 8/2 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: G63, E64, K94, G95
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 7/7 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, P85
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Lob 7/7 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, P85
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Lob 7/7 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, P85
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Lob 7/7 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, P85
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Lob 7/7 on CD40
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, P85
Source molecule (GenBank): P25942.1
Assay category: BCell
Result: Positive