Reference: Cristina Martín-Martín; Estefanía Salgado Del Riego; Jose R Vidal Castiñeira; Maria Soledad Zapico-Gonzalez; Mercedes Rodríguez-Pérez; Viviana Corte-Iglesias; Maria Laura Saiz; Paula Diaz-Bulnes; Dolores Escudero; Beatriz Suárez-Alvarez; Carlos López-Larrea. "Assessing Predictive Value of SARS-CoV-2 Epitope-Specific CD8<sup>+</sup> T-Cell Response in Patients with Severe Symptoms." Vaccines (2024).

Epitope: ORF1ab1637
Chemical type: Peptide from protein
Sequence: TTDPSFLGRY
Position: 1637-1646
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab1637
Chemical type: Peptide from protein
Sequence: TTDPSFLGRY
Position: 1637-1646
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S865
Chemical type: Peptide from protein
Sequence: LTDEMIAQY
Position: 865-873
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S865
Chemical type: Peptide from protein
Sequence: LTDEMIAQY
Position: 865-873
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S865
Chemical type: Peptide from protein
Sequence: LTDEMIAQY
Position: 865-873
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF3a207
Chemical type: Peptide from protein
Sequence: FTSDYYQLY
Position: 207-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF3a207
Chemical type: Peptide from protein
Sequence: FTSDYYQLY
Position: 207-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab1637
Chemical type: Peptide from protein
Sequence: ILFTRFFYV
Position: 2332-2340
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab1637
Chemical type: Peptide from protein
Sequence: ILFTRFFYV
Position: 2332-2340
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF3a139
Chemical type: Peptide from protein
Sequence: LLYDANYFL
Position: 139-147
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF3a139
Chemical type: Peptide from protein
Sequence: LLYDANYFL
Position: 139-147
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S269
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S269
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S269
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S1062
Chemical type: Peptide from protein
Sequence: FLHVTYVPA
Position: 1062-1070
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S1062
Chemical type: Peptide from protein
Sequence: FLHVTYVPA
Position: 1062-1070
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S1062
Chemical type: Peptide from protein
Sequence: FLHVTYVPA
Position: 1062-1070
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S995
Chemical type: Peptide from protein
Sequence: RLITGRLQSL
Position: 995-1004
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S995
Chemical type: Peptide from protein
Sequence: RLITGRLQSL
Position: 995-1004
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S995
Chemical type: Peptide from protein
Sequence: RLITGRLQSL
Position: 995-1004
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N221
Chemical type: Peptide from protein
Sequence: LLLLDRLNQL
Position: 221-230
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N221
Chemical type: Peptide from protein
Sequence: LLLLDRLNQL
Position: 221-230
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab4094
Chemical type: Peptide from protein
Sequence: ALWEIQQVV
Position: 4094-4102
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab4094
Chemical type: Peptide from protein
Sequence: ALWEIQQVV
Position: 4094-4102
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab 5538
Chemical type: Peptide from protein
Sequence: VVYRGTTTYK
Position: 5533-5542
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab 5538
Chemical type: Peptide from protein
Sequence: VVYRGTTTYK
Position: 5533-5542
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N362
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N362
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N362
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N362
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S378
Chemical type: Peptide from protein
Sequence: KCYGVSPTK
Position: 378-386
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S378
Chemical type: Peptide from protein
Sequence: KCYGVSPTK
Position: 378-386
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S378
Chemical type: Peptide from protein
Sequence: KCYGVSPTK
Position: 378-386
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N134
Chemical type: Peptide from protein
Sequence: ATEGALNTPK
Position: 134-143
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N134
Chemical type: Peptide from protein
Sequence: ATEGALNTPK
Position: 134-143
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab2600
Chemical type: Peptide from protein
Sequence: STFNVPMEK
Position: 2600-2608
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab2600
Chemical type: Peptide from protein
Sequence: STFNVPMEK
Position: 2600-2608
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M171
Chemical type: Peptide from protein
Sequence: ATSRTLSYYK
Position: 171-180
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M171
Chemical type: Peptide from protein
Sequence: ATSRTLSYYK
Position: 171-180
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab 5840
Chemical type: Peptide from protein
Sequence: VYIGDPAQL
Position: 5721-5729
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab 5840
Chemical type: Peptide from protein
Sequence: VYIGDPAQL
Position: 5721-5729
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N105
Chemical type: Peptide from protein
Sequence: SPRWYFYYL
Position: 105-113
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N105
Chemical type: Peptide from protein
Sequence: SPRWYFYYL
Position: 105-113
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S680
Chemical type: Peptide from protein
Sequence: SPRRARSVA
Position: 680-688
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S680
Chemical type: Peptide from protein
Sequence: SPRRARSVA
Position: 680-688
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S680
Chemical type: Peptide from protein
Sequence: SPRRARSVA
Position: 680-688
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab2949
Chemical type: Peptide from protein
Sequence: RPDTRYVL
Position: 2949-2956
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab2949
Chemical type: Peptide from protein
Sequence: RPDTRYVL
Position: 2949-2956
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab4344
Chemical type: Peptide from protein
Sequence: DLKGKYVQI
Position: 4344-4352
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab4344
Chemical type: Peptide from protein
Sequence: DLKGKYVQI
Position: 4344-4352
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N305
Chemical type: Peptide from protein
Sequence: QFAPSASAF
Position: 306-314
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N305
Chemical type: Peptide from protein
Sequence: QFAPSASAF
Position: 306-314
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo