Reference: Audrey Kassardjian; Danton Ivanochko; Brian Barber; Arif Jetha; Jean-Philippe Julien. "Humanization of Pan-HLA-DR mAb 44H10 Hinges on Critical Residues in the Antibody Framework." Antibodies (Basel, Switzerland) (2024).

Epitope: Epitope of 44H10 V22 Fab on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, P106, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: R58, Q63, E64, E65, R68, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.08

Epitope: Epitope of 44H10 V22 Fab on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, P106, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: R58, Q63, E64, E65, R68, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive

Epitope: Epitope of 44H10 V22 Fab on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, P106, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: R58, Q63, E64, E65, R68, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 29.1

Epitope: Epitope of 44H10 V22 Fab on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, P106, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: R58, Q63, E64, E65, R68, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00639

Epitope: Epitope of 44H10 V22 Fab on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, P106, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: R58, Q63, E64, E65, R68, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 220000.0

Epitope: Epitope of 44H10 on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: Q63, E64, T80, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00135

Epitope: Epitope of 44H10 on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: Q63, E64, T80, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive

Epitope: Epitope of 44H10 on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: Q63, E64, T80, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.23

Epitope: Epitope of 44H10 on HLA-DR
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T105, T108, N109, V110, P111, P112, E113, V114, D167, L169, G194, L195, D196, L199, K201; B: Q63, E64, T80, E81
Source molecule (GenBank): P01903.2
Assay category: BCell
Result: Positive
Quantitative measurement: 607000.0