Reference: Lei Wang; Julia Winnewisser; Christine Federle; Gregor Jessberger; Klaus-Armin Nave; Hauke B Werner; Bruno Kyewski; Ludger Klein; Maria Hinterberger. "Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis." Frontiers in immunology (2017).

Epitope: PLP 1-25
Chemical type: Peptide from protein
Sequence: GLLECCARCLVGAPFASLVATGLCF
Position: 2-26
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 16-40
Chemical type: Peptide from protein
Sequence: ASLVATGLCFFGVALFCGCGHEALT
Position: 17-41
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 32-56
Chemical type: Peptide from protein
Sequence: CGCGHEALTGTEKLIETYFSKNYQD
Position: 33-57
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 48-72
Chemical type: Peptide from protein
Sequence: TYFSKNYQDYEYLINVIHAFQYVIY
Position: 49-73
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 64-88
Chemical type: Peptide from protein
Sequence: IHAFQYVIYGTASFFFLYGALLLAE
Position: 65-89
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 80-104
Chemical type: Peptide from protein
Sequence: LYGALLLAEGFYTTGAVRQIFGDYK
Position: 81-105
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 96-120
Chemical type: Peptide from protein
Sequence: VRQIFGDYKTTICGKGLSATVTGGQ
Position: 97-121
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 112-136
Chemical type: Peptide from protein
Sequence: LSATVTGGQKGRGSRGQHQAHSLER
Position: 113-137
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive-Low
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 128-152
Chemical type: Peptide from protein
Sequence: QHQAHSLERVCHCLGKWLGHPDKFV
Position: 129-153
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 144-168
Chemical type: Peptide from protein
Sequence: WLGHPDKFVGITYALTVVWLLVFAC
Position: 145-169
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 160-184
Chemical type: Peptide from protein
Sequence: VVWLLVFACSAVPVYIYFNTWTTCQ
Position: 161-185
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 176-200
Chemical type: Peptide from protein
Sequence: YFNTWTTCQSIAFPSKTSASIGSLC
Position: 177-201
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive-Low
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 192-216
Chemical type: Peptide from protein
Sequence: TSASIGSLCADARMYGVLPWNAFPG
Position: 193-217
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 224-248
Chemical type: Peptide from protein
Sequence: LSICKTAEFQMTFHLFIAAFVGAAA
Position: 225-249
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 240-264
Chemical type: Peptide from protein
Sequence: IAAFVGAAATLVSLLTFMIAATYNF
Position: 241-265
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 256-276
Chemical type: Peptide from protein
Sequence: FMIAATYNFAVLKLMGRGTKF
Position: 257-277
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 173-184 epitope 2
Chemical type: Peptide from protein
Sequence: PVYIYFNTWTTC
Position: 173-184
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 173-184 epitope 2
Chemical type: Peptide from protein
Sequence: PVYIYFNTWTTC
Position: 173-184
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 173-184 epitope 2
Chemical type: Peptide from protein
Sequence: PVYIYFNTWTTC
Position: 173-184
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks

Epitope: PLP 10-21 epitope 1
Chemical type: Peptide from protein
Sequence: CLVGAPFASLVA
Position: 10-21
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks

Epitope: PLP 10-21 epitope 1
Chemical type: Peptide from protein
Sequence: CLVGAPFASLVA
Position: 10-21
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 10-21 epitope 1
Chemical type: Peptide from protein
Sequence: CLVGAPFASLVA
Position: 10-21
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 10-21 epitope 1
Chemical type: Peptide from protein
Sequence: CLVGAPFASLVA
Position: 10-21
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Negative
Host:  4-5 weeks

Epitope: PLP 239-250 epitope 3
Chemical type: Peptide from protein
Sequence: LFIAAFVGAAAT
Position: 239-250
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PLP 239-250 epitope 3
Chemical type: Peptide from protein
Sequence: LFIAAFVGAAAT
Position: 239-250
Source molecule (GenBank): P60201.2
Assay category: TCell
Result: Positive
Host:  4-5 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo