Reference: Lorraine D Hernandez; Heather K Kroh; Edward Hsieh; Xiaoyu Yang; Maribel Beaumont; Payal R Sheth; Edward DiNunzio; Stacey A Rutherford; Melanie D Ohi; Grigori Ermakov; Li Xiao; Susan Secore; Jerzy Karczewski; Fred Racine; Todd Mayhood; Paul Fischer; Xinwei Sher; Pulkit Gupta; D Borden Lacy; Alex G Therien. "Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab." Journal of molecular biology (2017).

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000113

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 610.0

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 187.0

Epitope: Actoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: G2162, V2163, F2164, K2165, G2166, P2167, N2168, G2169, F2170, E2171, Y2172, F2173, A2174, P2175, A2176, N2177, T2178, D2179, A2180, N2181, N2182, I2183, E2184, G2185, Q2186, A2187, I2188, L2189, G2410, V2411, F2412, K2413, G2414, P2415, N2416, G2417, F2418, E2419, Y2420, F2421, A2422, P2423, A2424, N2425, T2426, D2427, A2428, N2429, N2430, I2431, E2432, G2433, Q2434, A2435, I2436, L2437
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive