Reference: Meiying Shen; Siyin Chen; Xiaojian Han; Yanan Hao; Junfan Wang; Luo Li; Tong Chen; Bozhi Wang; Lin Zou; Tong Zhang; Wanli Zhang; Xiaxia Han; Wang Wang; Haochen Yu; Kang Li; Shengchun Liu; Aishun Jin. "Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations." Cancer immunology, immunotherapy : CII (2024).

Epitope: PI3K_E542
Chemical type: Peptide from protein
Sequence: AISTRDPLSE
Position: 533-542
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PI3K_E542
Chemical type: Peptide from protein
Sequence: AISTRDPLSE
Position: 533-542
Source molecule (GenBank): P42336.2
Assay category: MhcBinding
Result: Negative

Epitope: PI3K_E542K
Chemical type: Peptide, no natural source
Sequence: AISTRDPLSK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PI3K_E542K
Chemical type: Peptide, no natural source
Sequence: AISTRDPLSK
Assay category: MhcBinding
Result: Positive

Epitope: PI3K_H1047
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PI3K_H1047
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: MhcBinding
Result: Negative

Epitope: PI3K_H1047
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive

Epitope: PI3K_H1047L
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive