Reference: Naruhisa Ota; Christopher W Davies; Jing Kang; Donghong Yan; Alexis Scherl; Anne Wong; Ryan Cook; Xun Tao; Debra Dunlap; Sha Klabunde; Priscilla Mantik; Vishnu Mohanan; WeiYu Lin; Jacqueline McBride; Shraddha Sadekar; Kelly M Storek; Patrick Lupardus; Zhengmao Ye; Heidi Ackerly Wallweber; James R Kiefer; Min Xu; Pamela Chan; Karthik Nagapudi; Tangsheng Yi; James T Koerber. "Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling." Proceedings of the National Academy of Sciences of the United States of America (2025).

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.85

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2200000.0

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00016

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2000000.0

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.128

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00025

Epitope: Epitope of nanobody v134 on IL-23 R
Chemical type: Discontinuous protein residues
Discontinuous residues: I25, T26, N27, I28, C30, S31, I56, Y67, N69, G70, S98, Y100, T102, H108, Q110, E111, T112, L113, G116, K117, D118
Source molecule (GenBank): Q5VWK5.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.071