Reference: Ritika Tewari; Soo Jung Yang; Ethan D McClain; Alex Hu; Emma Mortensen; Aleah DeSchmidt; Janice Chen; Aravind Kancharla; Akhilesh K Singh; Eddie A James; Blaire E Burman; Asma Siddique; David J Rawlings; Chandra Patel; Karen Cerosaletti; Jane H Buckner. "Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy." Journal of autoimmunity (2024).

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PDC-E2 425-444
Chemical type: Peptide from protein
Sequence: ISNIRRVIAQRLMQSKQTIP
Position: 425-444
Source molecule (GenBank): P10515.3
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 108.917

Epitope: PDC-E2 432-444
Chemical type: Peptide from protein
Sequence: IAQRLMQSKQTIP
Position: 432-444
Source molecule (GenBank): P10515.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 72911.86

Epitope: PDC-E2 429-442
Chemical type: Peptide from protein
Sequence: RRVIAQRLMQSKQT
Position: 429-442
Source molecule (GenBank): P10515.3
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 26.984

Epitope: PDC-E2 425-444 V-R
Chemical type: Peptide, no natural source
Sequence: ISNIRRRIAQRLMQSKQTIP
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 34576.42

Epitope: GAD 555-567
Chemical type: Peptide, no natural source
Sequence: NFIRMVISNPAAT
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 412.707