Reference: R R Latek; A Suri; S J Petzold; C A Nelson; O Kanagawa; E R Unanue; D H Fremont. "Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice." Immunity (2000).

Epitope: HEL (11-25)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGYSL
Position: 29-43
Source molecule (GenBank): P00698.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: HEL (11-25)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGYSL
Position: 29-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.1

Epitope: HEL (11-25)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGYSL
Position: 29-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 9200.0

Epitope: HEL (11-25)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGYSL
Position: 29-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 6000.0

Epitope: G6PI
Chemical type: Peptide from protein
Sequence: LSIALHVGFDHFE
Position: 282-294
Source molecule (GenBank): NP_032181.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 18700.0

Epitope: GAD65b
Chemical type: Peptide from protein
Sequence: KKMREIIGWPGGSG
Position: 222-235
Source molecule (GenBank): P48320.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 15500.0

Epitope: MSA
Chemical type: Peptide from protein
Sequence: ATAEQLKTVMDD
Position: 563-574
Source molecule (GenBank): P07724.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 32000.0

Epitope: Tnf
Chemical type: Peptide from protein
Sequence: NYVTAIRNQQEG
Position: 337-348
Source molecule (GenBank): Q921I1.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 7800.0

Epitope: HEL variant 1
Chemical type: Peptide, no natural source
Sequence: AMKAHGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 5700.0

Epitope: HEL variant 2
Chemical type: Peptide, no natural source
Sequence: AMKFHGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 12100.0

Epitope: HEL variant 3
Chemical type: Peptide, no natural source
Sequence: AMKDHGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 90000.0

Epitope: HEL variant 4
Chemical type: Peptide, no natural source
Sequence: AMKKHGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 5700.0

Epitope: HEL variant 6
Chemical type: Peptide, no natural source
Sequence: AMKRHGNDNYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 51700.0

Epitope: HEL variant 7
Chemical type: Peptide, no natural source
Sequence: AMKRHGDDNYRGYSL
Assay category: MhcBinding
Result: Negative

Epitope: HEL variant 8
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDAYRGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 5700.0

Epitope: HEL variant 9
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDLYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 24700.0

Epitope: HEL variant 10
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDEYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 121700.0

Epitope: HEL variant 11
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDYYRGYSL
Assay category: MhcBinding
Result: Negative

Epitope: HEL variant 12
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNARGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 45000.0

Epitope: HEL variant 14
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYRDYSL
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 9500.0

Epitope: HEL variant 15
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYREYSL
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 4000.0

Epitope: HEL variant 16
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYRKYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 26000.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AAKRHGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 9300.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRAGLDNYRGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 7000.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHALDNYRGYSL
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 16700.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHGLANYRGYSL
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 3200.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYAGYSL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 9200.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYRGASL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 7500.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYRGYAL
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 6800.0

Epitope: HEL variant
Chemical type: Peptide, no natural source
Sequence: AMKRHGLDNYRGYSA
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 6200.0

Epitope: HEL (11-24)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGYS
Position: 29-42
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 10700.0

Epitope: HEL (11-23)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYRGY
Position: 29-41
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 7800.0

Epitope: HEL (11-21)
Chemical type: Peptide from protein
Sequence: AMKRHGLDNYR
Position: 29-39
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 113000.0

Epitope: HEL (11-19)
Chemical type: Peptide from protein
Sequence: AMKRHGLDN
Position: 29-37
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Negative

Epitope: HEL (17-25)
Chemical type: Peptide from protein
Sequence: LDNYRGYSL
Position: 35-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Negative

Epitope: HEL (16-25)
Chemical type: Peptide from protein
Sequence: GLDNYRGYSL
Position: 34-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Negative

Epitope: HEL (15-25)
Chemical type: Peptide from protein
Sequence: HGLDNYRGYSL
Position: 33-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 92000.0

Epitope: HEL (14-25)
Chemical type: Peptide from protein
Sequence: RHGLDNYRGYSL
Position: 32-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 16700.0

Epitope: HEL (13-25)
Chemical type: Peptide from protein
Sequence: KRHGLDNYRGYSL
Position: 31-43
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 5100.0

Epitope: HEL (14-22)
Chemical type: Peptide from protein
Sequence: RHGLDNYRG
Position: 32-40
Source molecule (GenBank): P00698.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 20000.0