Reference: Bryan Smith; Andrea Kiessling; Rocio Lledo-Garcia; Kate L Dixon; Louis Christodoulou; Matthew C Catley; Paul Atherfold; Lena E D'Hooghe; Helene Finney; Kevin Greenslade; Hanna Hailu; Lara Kevorkian; Daniel Lightwood; Christoph Meier; Rebecca Munro; Omar Qureshi; Kaushik Sarkar; Sophie P Shaw; Roohi Tewari; Alison Turner; Kerry Tyson; Shauna West; Stevan Shaw; Frank R Brennan. "Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration." mAbs (2018).

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.37

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.1

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000012

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 11000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 120000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 0.013

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 440000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 430000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.9

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000010

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.025

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 990000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 85000.0

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 0.0084

Epitope: Epitope of rozanolixizumab (UCB7665; 1519.g57 IgG4P) on FcRn
Chemical type: Discontinuous protein residues
Discontinuous residues: V128, P129, T130, A131, K132, E138, E139, F140, M141, N142, F143, D144, L145, K146, Q147, G152, D153, W154, P155, E156
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.023