Reference: Katarzyna Skrzypczynska; Kristin Schimert; Heather Stephenson; In Kyoung Mah; David Mortenson; Kelli Boyd; Timothy Hardman; Nikolai Novikov; Elbert Seto; Sabrina Lu; Randy Yen; Brian Lee; Min Wang; Don Kang; Ying Huang; Xinchao Yu; Magdeleine Hung; Sheng Ding; Nathan Thomsen; Nicole Schirle Oakdale. "Development of a PRAME pMHC targeted T cell engager for solid tumor therapy." mAbs (2025).

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 100
Chemical type: Peptide from protein
Sequence: VLDGLDVLLA
Position: 100-109
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 142
Chemical type: Peptide from protein
Sequence: SLYSFPEPEA
Position: 142-151
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 300
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 371
Chemical type: Peptide from protein
Sequence: ALLERASATL
Position: 371-380
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 394
Chemical type: Peptide from protein
Sequence: QLLALLPSL
Position: 394-402
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.6

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00156

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 430000.0

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.8

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00159

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 331000.0

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 70.8

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 22.8

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00239

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 105000.0

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0137

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive
Quantitative measurement: 194000.0

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: BCell
Result: Positive

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Low

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Negative

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-High

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: PRAME 425
Chemical type: Peptide from protein
Sequence: SLLQHLIGL
Position: 425-433
Source molecule (GenBank): P78395.1
Assay category: MhcLigandElution
Result: Positive-Intermediate

Epitope: Epitope of VHH anti-kappa on mAb HU-38
Chemical type: Discontinuous protein residues
Discontinuous residues: P8, S12, K107, T109, V110, Y140, P141, E143, K145, T197, H198, Q199, G200, L201, S202
Source molecule (GenBank): P0DOX7.1
Assay category: BCell
Result: Positive