Reference: Vishal N Rao; Iden A Sapse; Hallie Cohn; Duck-Kyun Yoo; Pei Tong; Jordan J Clark; Bailey Bozarth; Yuexing Chen; Komal Srivastava; Gagandeep Singh; Florian Krammer; Viviana Simon; Duane R Wesemann; Goran Bajic; Camila H Coelho. "Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope." Cell reports (2025).

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive
Quantitative measurement: 300.0

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Negative

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Negative

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab M15 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Q762, L763, R765, A766, I770, E773, Q954, Q965, L1001, Q1002, Q1005, T1006, V1008, T1009, Q1010, L1012, I1013, R1014, A1015, A1016, E1017
Source molecule (GenBank): QHO60594.1
Assay category: BCell
Result: Positive