Reference: Benjamine Arellano; Rehana Hussain; Tresa Zacharias; Jane Yoon; Chella David; Sima Zein; Lawrence Steinman; Thomas Forsthuber; Benjamin M Greenberg; Doris Lambracht-Washington; Alanna M Ritchie; Jeffrey L Bennett; Olaf Stüve. "Human aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01: relevance for diagnosing and monitoring patients with neuromyelitis optica." Archives of neurology (2012).

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: MSDRPTARRWGKCGPLCTRE
Position: 1-20
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: MSDRPTARRWGKCGPLCTRE
Position: 1-20
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (11-30)
Chemical type: Peptide from protein
Sequence: GKCGPLCTRENIMVAFKGVW
Position: 11-30
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (11-30)
Chemical type: Peptide from protein
Sequence: GKCGPLCTRENIMVAFKGVW
Position: 11-30
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (21-40)
Chemical type: Peptide from protein
Sequence: NIMVAFKGVWTQAFWKAVTA
Position: 21-40
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (21-40)
Chemical type: Peptide from protein
Sequence: NIMVAFKGVWTQAFWKAVTA
Position: 21-40
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (31-50)
Chemical type: Peptide from protein
Sequence: TQAFWKAVTAEFLAMLIFVL
Position: 31-50
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (31-50)
Chemical type: Peptide from protein
Sequence: TQAFWKAVTAEFLAMLIFVL
Position: 31-50
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (41-60)
Chemical type: Peptide from protein
Sequence: EFLAMLIFVLLSLGSTINWG
Position: 41-60
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (41-60)
Chemical type: Peptide from protein
Sequence: EFLAMLIFVLLSLGSTINWG
Position: 41-60
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (51-70)
Chemical type: Peptide from protein
Sequence: LSLGSTINWGGTEKPLPVDM
Position: 51-70
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (51-70)
Chemical type: Peptide from protein
Sequence: LSLGSTINWGGTEKPLPVDM
Position: 51-70
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (61-80)
Chemical type: Peptide from protein
Sequence: GTEKPLPVDMVLISLCFGLS
Position: 61-80
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (61-80)
Chemical type: Peptide from protein
Sequence: GTEKPLPVDMVLISLCFGLS
Position: 61-80
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (71-90)
Chemical type: Peptide from protein
Sequence: VLISLCFGLSIATMVQCFGH
Position: 71-90
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (71-90)
Chemical type: Peptide from protein
Sequence: VLISLCFGLSIATMVQCFGH
Position: 71-90
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (91-110)
Chemical type: Peptide from protein
Sequence: IATMVQCFGHISGGHINPAV
Position: 81-100
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (91-110)
Chemical type: Peptide from protein
Sequence: IATMVQCFGHISGGHINPAV
Position: 81-100
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4
Chemical type: Peptide from protein
Sequence: ISGGHINPAVTVAMVCTRKI
Position: 91-110
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4
Chemical type: Peptide from protein
Sequence: ISGGHINPAVTVAMVCTRKI
Position: 91-110
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (101-120)
Chemical type: Peptide from protein
Sequence: TVAMVCTRKISIAKSVFYIA
Position: 101-120
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (101-120)
Chemical type: Peptide from protein
Sequence: TVAMVCTRKISIAKSVFYIA
Position: 101-120
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: SIAKSVFYIAAQCLGAIIGA
Position: 111-130
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: SIAKSVFYIAAQCLGAIIGA
Position: 111-130
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: AQCLGAIIGAGILYLVTPPS
Position: 121-140
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: AQCLGAIIGAGILYLVTPPS
Position: 121-140
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: GILYLVTPPSVVGGLGVTMV
Position: 131-150
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: GILYLVTPPSVVGGLGVTMV
Position: 131-150
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: VVGGLGVTMVHGNLTAGHGL
Position: 141-160
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: VVGGLGVTMVHGNLTAGHGL
Position: 141-160
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: HGNLTAGHGLLVELIITFQL
Position: 151-170
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: HGNLTAGHGLLVELIITFQL
Position: 151-170
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: LVELIITFQLVFTIFASCDS
Position: 161-180
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: LVELIITFQLVFTIFASCDS
Position: 161-180
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: VFTIFASCDSKRTDVTGSIA
Position: 171-190
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: VFTIFASCDSKRTDVTGSIA
Position: 171-190
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: KRTDVTGSIALAIGFSVAIG
Position: 181-200
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: KRTDVTGSIALAIGFSVAIG
Position: 181-200
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: LAIGFSVAIGHLFAINYTGA
Position: 191-210
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: LAIGFSVAIGHLFAINYTGA
Position: 191-210
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: HLFAINYTGASMNPARSFGP
Position: 201-220
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (1-20)
Chemical type: Peptide from protein
Sequence: HLFAINYTGASMNPARSFGP
Position: 201-220
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (211-230)
Chemical type: Peptide from protein
Sequence: SMNPARSFGPAVIMGNWENH
Position: 211-230
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (211-230)
Chemical type: Peptide from protein
Sequence: SMNPARSFGPAVIMGNWENH
Position: 211-230
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (231-250)
Chemical type: Peptide from protein
Sequence: WIYWVGPIIGAVLAGGLYEY
Position: 231-250
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (231-250)
Chemical type: Peptide from protein
Sequence: WIYWVGPIIGAVLAGGLYEY
Position: 231-250
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (241-260)
Chemical type: Peptide from protein
Sequence: AVLAGGLYEYVFCPDVEFKR
Position: 241-260
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (241-260)
Chemical type: Peptide from protein
Sequence: AVLAGGLYEYVFCPDVEFKR
Position: 241-260
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (251-270)
Chemical type: Peptide from protein
Sequence: VFCPDVEFKRRFKEAFSKAA
Position: 251-270
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (251-270)
Chemical type: Peptide from protein
Sequence: VFCPDVEFKRRFKEAFSKAA
Position: 251-270
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (261-280)
Chemical type: Peptide from protein
Sequence: RFKEAFSKAAQQTKGSYMEV
Position: 261-280
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (261-280)
Chemical type: Peptide from protein
Sequence: RFKEAFSKAAQQTKGSYMEV
Position: 261-280
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (271-290)
Chemical type: Peptide from protein
Sequence: QQTKGSYMEVEDNRSQVETD
Position: 271-290
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (271-290)
Chemical type: Peptide from protein
Sequence: QQTKGSYMEVEDNRSQVETD
Position: 271-290
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (281-300)
Chemical type: Peptide from protein
Sequence: EDNRSQVETDDLILKPGVVH
Position: 281-300
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Positive
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (291-310)
Chemical type: Peptide from protein
Sequence: DLILKPGVVHVIDVDRGEEK
Position: 291-310
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (291-310)
Chemical type: Peptide from protein
Sequence: DLILKPGVVHVIDVDRGEEK
Position: 291-310
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (301-320)
Chemical type: Peptide from protein
Sequence: VIDVDRGEEKKGKDQSGEVL
Position: 301-320
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: AQP4 (301-320)
Chemical type: Peptide from protein
Sequence: VIDVDRGEEKKGKDQSGEVL
Position: 301-320
Source molecule (GenBank): P55087.2
Assay category: TCell
Result: Negative
Host: M 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo