Reference: Frauke Muecksch; Yiska Weisblum; Christopher O Barnes; Fabian Schmidt; Dennis Schaefer-Babajew; Zijun Wang; Julio C C Lorenzi; Andrew I Flyak; Andrew T DeLaitsch; Kathryn E Huey-Tubman; Shurong Hou; Celia A Schiffer; Christian Gaebler; Justin Da Silva; Daniel Poston; Shlomo Finkin; Alice Cho; Melissa Cipolla; Thiago Y Oliveira; Katrina G Millard; Victor Ramos; Anna Gazumyan; Magdalena Rutkowska; Marina Caskey; Michel C Nussenzweig; Pamela J Bjorkman; Theodora Hatziioannou; Paul D Bieniasz. "Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations." Immunity (2021).

Epitope: Epitope of CR3022 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, K386, D389, L390, D428, T430, L517
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of C099 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, T500, N501, G502, G504, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C099 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, T500, N501, G502, G504, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of C099 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, T500, N501, G502, G504, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0039

Epitope: Epitope of C099 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, T500, N501, G502, G504, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C098 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, Y495, T500, N501, G502, V503, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of C098 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, Y495, T500, N501, G502, V503, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.03

Epitope: Epitope of C098 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, Y495, T500, N501, G502, V503, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 29.05

Epitope: Epitope of C098 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, Y495, T500, N501, G502, V503, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of C098 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, L455, F456, R457, K458, N460, Y473, A475, G476, S477, F486, N487, Y489, Q493, Y495, T500, N501, G502, V503, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C032 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G339, E340, N343, A344, T345, R346, N437, N440, L441, D442, S443, K444, V445, N448, Y451, P499, T500
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C032 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G339, E340, N343, A344, T345, R346, N437, N440, L441, D442, S443, K444, V445, N448, Y451, P499, T500
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C032 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G339, E340, N343, A344, T345, R346, N437, N440, L441, D442, S443, K444, V445, N448, Y451, P499, T500
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of C032 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G339, E340, N343, A344, T345, R346, N437, N440, L441, D442, S443, K444, V445, N448, Y451, P499, T500
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 30.25

Epitope: Epitope of C051 Fab on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K417, K444, Y449, N450, L452, L455, V483, E484, G485, F486, N487, Y489, F490, Q493, S494, Y495, Q498; B: N343, N370, S371, A372, S373, W436
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C051 Fab on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K417, K444, Y449, N450, L452, L455, V483, E484, G485, F486, N487, Y489, F490, Q493, S494, Y495, Q498; B: N343, N370, S371, A372, S373, W436
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0031

Epitope: Epitope of C051 Fab on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K417, K444, Y449, N450, L452, L455, V483, E484, G485, F486, N487, Y489, F490, Q493, S494, Y495, Q498; B: N343, N370, S371, A372, S373, W436
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C051 Fab on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: K417, K444, Y449, N450, L452, L455, V483, E484, G485, F486, N487, Y489, F490, Q493, S494, Y495, Q498; B: N343, N370, S371, A372, S373, W436
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C052 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: E484
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C052 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: E484
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.96

Epitope: Epitope of C052 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: E484
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C055 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G485, F486
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C055 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G485, F486
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 6.99

Epitope: Epitope of C055 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: G485, F486
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C512 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, K444, G446
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C512 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, K444, G446
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.74