Reference: Branislav Kovacech; Lubica Fialova; Peter Filipcik; Rostislav Skrabana; Monika Zilkova; Natalia Paulenka-Ivanovova; Andrej Kovac; Denisa Palova; Gabriela Paulikova Rolkova; Katarina Tomkova; Natalia Turic Csokova; Karina Markova; Michaela Skrabanova; Kristina Sinska; Neha Basheer; Petra Majerova; Jozef Hanes; Vojtech Parrak; Michal Prcina; Ondrej Cehlar; Martin Cente; Juraj Piestansky; Michal Fresser; Michal Novak; Monika Slavikova; Kristina Borsova; Viktoria Cabanova; Bronislava Brejova; Tomas Vinař; Jozef Nosek; Boris Klempa; Ludek Eyer; Vaclav Hönig; Martin Palus; Daniel Ruzek; Tereza Vyhlidalova; Petra Strakova; Blanka Mrazkova; Dagmar Zudova; Gizela Koubkova; Vendula Novosadova; Jan Prochazka; Radislav Sedlacek; Norbert Zilka; Eva Kontsekova. "Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern." EBioMedicine (2022).

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.47
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000762
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 520000.0
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX677
Chemical type: Discontinuous protein residues
Discontinuous residues: I358, S359, N360, C361, V362, A363, D364, I434, A435, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, G447, N448, Y449, N450, Y451, L452, Y453, R454, L455
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.572
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1060000.0
Host:  6 weeks

Epitope: mAb AX290
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNGVEGFNCYFPLQSY
Position: 467-495
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000609
Host:  6 weeks