Reference: Colton J Bracken; Shion A Lim; Paige Solomon; Nicholas J Rettko; Duy P Nguyen; Beth Shoshana Zha; Kaitlin Schaefer; James R Byrnes; Jie Zhou; Irene Lui; Jia Liu; Katarina Pance; Xin X Zhou; Kevin K Leung; James A Wells. "Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2." Nature chemical biology (2021).

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.109

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VH3 B01 on SARS-CoV-2 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R403, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, C488, Y489, Q493, S494, Y495, G496, Q498, N501, Y505; B: K378, R403, D405, R408, Q409, G413, Q414, T415, G416, K417, Y421, Y449, Y453, L455, F456, R457, Y473, A475, E484, G485, F486, N487, Y489, Q493, S494, G496, Q498, N501, V503, Y505; C: R403, K417, Y421, Y449, L452, Y453, R454, Q493, S494, Y495, G496, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive