Reference: Kenji Murata; Dalam Ly; Hiroshi Saijo; Yukiko Matsunaga; Kenji Sugata; Fumie Ihara; Daisuke Oryoji; Yota Ohashi; Kayoko Saso; Chung-Hsi Wang; Evey Y F Zheng; Brian D Burt; Marcus O Butler; Naoto Hirano. "Modification of the HLA-A*24:02 Peptide Binding Pocket Enhances Cognate Peptide-Binding Capacity and Antigen-Specific T Cell Activation." Journal of immunology (Baltimore, Md. : 1950) (2022).

Epitope: CMV IE1
Chemical type: Peptide from protein
Sequence: AYAQKIFKI
Position: 248-256
Source molecule (GenBank): AKI20200.1
Assay category: MhcBinding
Result: Positive

Epitope: Adenovirus 5 Hexon
Chemical type: Peptide from protein
Sequence: TYFSLNNKF
Position: 37-45
Source molecule (GenBank): WEG78433.1
Assay category: MhcBinding
Result: Positive

Epitope: CMV pp65
Chemical type: Peptide from protein
Sequence: VYALPLKML
Position: 113-121
Source molecule (GenBank): AKI22339.1
Assay category: MhcBinding
Result: Positive

Epitope: HIV env
Chemical type: Peptide from protein
Sequence: RYLKDQQLL
Position: 632-640
Source molecule (GenBank): AFB37143.1
Assay category: MhcBinding
Result: Positive

Epitope: EpCAM
Chemical type: Peptide from protein
Sequence: RYQLDPKFI
Position: 201-209
Source molecule (GenBank): KAI2523295.1
Assay category: MhcBinding
Result: Positive

Epitope: KM-HN-1
Chemical type: Peptide from protein
Sequence: EYLSLSDKI
Position: 770-778
Source molecule (GenBank): XP_011530129.1
Assay category: MhcBinding
Result: Positive

Epitope: NY-ESO-1
Chemical type: Peptide, no natural source
Sequence: SLLMWITQV
Assay category: TCell
Result: Positive
Host: F 81 years
Cell type: Jurkat cell (T cell)
Tissue: lymphoid
Culture conditions: Engineered

Epitope: gp100 154-162
Chemical type: Peptide from protein
Sequence: KTWGQYWQV
Position: 154-162
Source molecule (GenBank): P40967.2
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: lymphoid
Culture conditions: Engineered

Epitope: beta-catenin
Chemical type: Peptide, no natural source
Sequence: SYLDSGIHF
Assay category: MhcBinding
Result: Positive-High

Epitope: KM-HN-1
Chemical type: Peptide from protein
Sequence: NYNNFYRFL
Position: 196-204
Source molecule (GenBank): Q8TBZ0.1
Assay category: MhcBinding
Result: Positive-High

Epitope: KM-HN-1
Chemical type: Peptide from protein
Sequence: EYSKECLKEF
Position: 462-471
Source molecule (GenBank): Q8TBZ0-2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: KM-HN-1
Chemical type: Peptide from protein
Sequence: EYLSLSDKI
Position: 733-741
Source molecule (GenBank): Q8TBZ0-2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: MAGE-A2
Chemical type: Peptide from protein
Sequence: EYLQLVFGI
Position: 156-164
Source molecule (GenBank): P43356.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: MAGE-A3
Chemical type: Peptide from protein
Sequence: TFPDLESEF
Position: 97-105
Source molecule (GenBank): P43357.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A3
Chemical type: Peptide from protein
Sequence: VAELVHFLL
Position: 113-121
Source molecule (GenBank): P43357.1
Assay category: MhcBinding
Result: Positive-High

Epitope: NY-ESO-1 91
Chemical type: Peptide from protein
Sequence: YLAMPFATPME
Position: 91-101
Source molecule (GenBank): P78358-2
Assay category: MhcBinding
Result: Positive-Low

Epitope: SAGE
Chemical type: Peptide from protein
Sequence: LYATVIHDI
Position: 715-723
Source molecule (GenBank): Q9NXZ1.2
Assay category: MhcBinding
Result: Positive-High

Epitope: CEA
Chemical type: Peptide from protein
Sequence: QYSWFVNGTF
Position: 268-277
Source molecule (GenBank): A0A024R0K5.1
Assay category: MhcBinding
Result: Positive-High

Epitope: CEA
Chemical type: Peptide from protein
Sequence: TYACFVSNL
Position: 474-482
Source molecule (GenBank): A0A087WYX0.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: gp100-intron4
Chemical type: Peptide, no natural source
Sequence: VYFFLPDHL
Assay category: TCell
Result: Positive
Cell type: T cell CD3+
Tissue: blood
Culture conditions: Engineered

Epitope: gp100-intron4
Chemical type: Peptide, no natural source
Sequence: VYFFLPDHL
Assay category: TCell
Result: Negative
Cell type: T cell CD3+
Tissue: blood
Culture conditions: Engineered

Epitope: gp100-intron4
Chemical type: Peptide, no natural source
Sequence: VYFFLPDHL
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: gp100-intron4
Chemical type: Peptide, no natural source
Sequence: VYFFLPDHL
Assay category: MhcBinding
Result: Positive-High

Epitope: OA1
Chemical type: Peptide from protein
Sequence: LYSACFWWL
Position: 42-50
Source molecule (GenBank): H7BZN6.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Tyrosinase
Chemical type: Peptide from protein
Sequence: AFLPWHRLF
Position: 206-214
Source molecule (GenBank): P14679.3
Assay category: MhcBinding
Result: Positive-High

Epitope: Tyrosinase
Chemical type: Peptide from protein
Sequence: IYMDGTADFSF
Assay category: MhcBinding
Result: Positive-High

Epitope: EpCAM
Chemical type: Peptide from protein
Sequence: RYQLDPKFI
Position: 201-209
Source molecule (GenBank): B5MCA4.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: EZH2
Chemical type: Peptide from protein
Sequence: KYDCFLHPF
Position: 291-299
Source molecule (GenBank): Q15910.2
Assay category: MhcBinding
Result: Positive-High

Epitope: EZH2
Chemical type: Peptide from protein
Sequence: KYVGIEREM
Position: 735-743
Source molecule (GenBank): Q15910.2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: glypican-3
Chemical type: Peptide from protein
Sequence: EYILSLEEL
Position: 244-252
Source molecule (GenBank): P51654-2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: HER-2/new
Chemical type: Peptide from protein
Sequence: TYLPTNASL
Position: 63-71
Source molecule (GenBank): P04626.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MUC5AC
Chemical type: Peptide from protein
Sequence: TCQPTCRSL
Position: 716-724
Source molecule (GenBank): P98088.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: PRAME
Chemical type: Peptide from protein
Sequence: LYVDSLFFL
Position: 301-309
Source molecule (GenBank): P78395.1
Assay category: MhcBinding
Result: Positive-High

Epitope: PSMA
Chemical type: Peptide from protein
Sequence: NYARTEDFF
Position: 121-129
Source molecule (GenBank): Q04609-6
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: RNF43
Chemical type: Peptide from protein
Sequence: NSQPVWLCL
Position: 721-729
Source molecule (GenBank): Q68DV7.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MIA
Chemical type: Peptide from protein
Sequence: YYGDLAARL
Position: 92-100
Source molecule (GenBank): W4VSR3.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: GAPDHS
Chemical type: Peptide from protein
Sequence: RYKGSVEF
Position: 58-65
Source molecule (GenBank): K7EP73.1
Assay category: MhcBinding
Result: Positive-High

Epitope: EXTL1
Chemical type: Peptide from protein
Sequence: FYHRYYHTLF
Position: 557-566
Source molecule (GenBank): Q92935.2
Assay category: MhcBinding
Result: Positive-High

Epitope: CPN1
Chemical type: Peptide from protein
Sequence: VYSYAHGWMF
Position: 257-266
Source molecule (GenBank): P15169.1
Assay category: MhcBinding
Result: Positive-High

Epitope: TSPAN10
Chemical type: Peptide from protein
Sequence: KYLIFLSNF
Position: 77-85
Source molecule (GenBank): A0A087X235.1
Assay category: MhcBinding
Result: Negative

Epitope: GJB1
Chemical type: Peptide from protein
Sequence: VWLSVIFIF
Position: 23-31
Source molecule (GenBank): A0A2R8YD01.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: DUSP4
Chemical type: Peptide from protein
Sequence: RFSSEYPEF
Position: 149-157
Source molecule (GenBank): Q13115.1
Assay category: MhcBinding
Result: Positive-High

Epitope: cyclic-A1
Chemical type: Peptide from protein
Sequence: IYPPEVDEF
Position: 259-267
Source molecule (GenBank): P78396-3
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A1
Chemical type: Peptide from protein
Sequence: IMPKTGFLI
Position: 188-196
Source molecule (GenBank): P43355.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A3
Chemical type: Peptide from protein
Sequence: IMPKAGLLI
Position: 195-203
Source molecule (GenBank): P43357.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A9
Chemical type: Peptide from protein
Sequence: VYYTLWSQF
Position: 71-79
Source molecule (GenBank): A0A075B798.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A10
Chemical type: Peptide from protein
Sequence: NYEDHFPLLF
Position: 167-176
Source molecule (GenBank): P43363.2
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-A12
Chemical type: Peptide from protein
Sequence: SYPPLHEWAF
Position: 300-309
Source molecule (GenBank): P43365.2
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-C1
Chemical type: Peptide from protein
Sequence: RYTGYFPVIF
Position: 941-950
Source molecule (GenBank): O60732.3
Assay category: MhcBinding
Result: Positive-High

Epitope: SSX2
Chemical type: Peptide from protein
Sequence: KYEAMTKLGF
Position: 95-104
Source molecule (GenBank): O60225-2
Assay category: MhcBinding
Result: Positive-High

Epitope: SSX2
Chemical type: Peptide from protein
Sequence: VYMKRKYEAM
Position: 49-58
Source molecule (GenBank): A0A087WWQ6.1
Assay category: MhcBinding
Result: Positive-High

Epitope: CD274
Chemical type: Peptide from protein
Sequence: IFMTYWHLL
Position: 8-16
Source molecule (GenBank): Q9NZQ7.1
Assay category: MhcBinding
Result: Positive-High

Epitope: cyclin D1
Chemical type: Peptide from protein
Sequence: NYLDRFLSL
Position: 83-91
Source molecule (GenBank): P24385.1
Assay category: MhcBinding
Result: Positive-High

Epitope: IDO1
Chemical type: Peptide from protein
Sequence: RYMPPAHRNF
Position: 297-306
Source molecule (GenBank): P14902.1
Assay category: MhcBinding
Result: Positive-High

Epitope: SOX10
Chemical type: Peptide from protein
Sequence: HYGSAFPSI
Position: 387-395
Source molecule (GenBank): P56693.1
Assay category: MhcBinding
Result: Positive-High

Epitope: NY-ESO-1 160
Chemical type: Peptide from protein
Sequence: MWITQCFLPVF
Position: 160-170
Source molecule (GenBank): P78358.1
Assay category: MhcBinding
Result: Positive-High

Epitope: NY-ESO-1 158
Chemical type: Peptide from protein
Sequence: LLMWITQCF
Position: 158-166
Source molecule (GenBank): P78358.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: hTERT
Chemical type: Peptide from protein
Sequence: VYGFVRACL
Position: 461-469
Source molecule (GenBank): AAC51724.1
Assay category: MhcBinding
Result: Positive-High

Epitope: WT1 (wild-type)
Chemical type: Peptide from protein
Sequence: CMTWNQMNL
Position: 235-243
Source molecule (GenBank): P19544.2
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: lymphoid
Culture conditions: Engineered

Epitope: WT1 (wild-type)
Chemical type: Peptide from protein
Sequence: CMTWNQMNL
Position: 235-243
Source molecule (GenBank): P19544.2
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: lymphoid
Culture conditions: Engineered

Epitope: WT1 (wild-type)
Chemical type: Peptide from protein
Sequence: CMTWNQMNL
Position: 235-243
Source molecule (GenBank): P19544.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: WT1 (heteroclitic)
Chemical type: Peptide, no natural source
Sequence: CYTWNQMNL
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: lymphoid
Culture conditions: Engineered

Epitope: WT1 (heteroclitic)
Chemical type: Peptide, no natural source
Sequence: CYTWNQMNL
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: MAGE-A4 (heteroclitic)
Chemical type: Peptide, no natural source
Sequence: NYKRCFPVF
Assay category: MhcBinding
Result: Positive-High

Epitope: CPN1
Chemical type: Peptide from protein
Sequence: YLHTNCFEI
Position: 461-469
Source molecule (GenBank): Q66K79.2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: PRAME
Chemical type: Peptide from protein
Sequence: ALYVDSLFFL
Position: 300-309
Source molecule (GenBank): P78395.1
Assay category: MhcBinding
Result: Positive-High

Epitope: HIV env
Chemical type: Peptide from protein
Sequence: RYLRDQQLL
Position: 583-591
Source molecule (GenBank): AKZ15547.1
Assay category: MhcBinding
Result: Positive-High