Reference: Chu Zheng; Adonis A Rubio; Sheena Vasquez; Dominic Pham; Zhuangyu Pan; Christopher O Barnes; Peter S Kim. "Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein." ACS central science (2026).

Epitope: Epitope of mAb REGN3470 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E245, R247, T259, T262, S263, G264, K265, K276, V277, N278, P279, E280, I281, D282, T283, R302, S303, E304, E305, L306, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb REGN3470 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E245, R247, T259, T262, S263, G264, K265, K276, V277, N278, P279, E280, I281, D282, T283, R302, S303, E304, E305, L306, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb REGN3470 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E245, R247, T259, T262, S263, G264, K265, K276, V277, N278, P279, E280, I281, D282, T283, R302, S303, E304, E305, L306, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 1-2 months

Epitope: Epitope of mAb c13C6 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: P116, D117, G143, T144, Q221,T223, L233, T240, N268, T269, T270, G271, K272, L273, I274, W275, E305, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb c13C6 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: P116, D117, G143, T144, Q221,T223, L233, T240, N268, T269, T270, G271, K272, L273, I274, W275, E305, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb c13C6 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: P116, D117, G143, T144, Q221,T223, L233, T240, N268, T269, T270, G271, K272, L273, I274, W275, E305, S307, F308
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-High
Host: F 1-2 months

Epitope: Epitope of mAb114 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E112, K114, K115, P116, D117, G118, S119, E120, S142, G143, T144, G145, P146, C147, Q221, A222, T223, G224, T227, E231, L233, N238, L239, T240, Y241, T269
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb114 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E112, K114, K115, P116, D117, G118, S119, E120, S142, G143, T144, G145, P146, C147, Q221, A222, T223, G224, T227, E231, L233, N238, L239, T240, Y241, T269
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb114 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E112, K114, K115, P116, D117, G118, S119, E120, S142, G143, T144, G145, P146, C147, Q221, A222, T223, G224, T227, E231, L233, N238, L239, T240, Y241, T269
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-High
Host: F 1-2 months

Epitope: Epitope of mAb100 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: I33, P34, D47, D49, A503, I504, V505, N506, A507, Q508,K510, C511, N512, P513, N514, D522, E523, G524, A525, A526, I527, G528, Q560, N563, E564, T565, T566, Q567, A568, L569, L571
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb100 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: I33, P34, D47, D49, A503, I504, V505, N506, A507, Q508,K510, C511, N512, P513, N514, D522, E523, G524, A525, A526, I527, G528, Q560, N563, E564, T565, T566, Q567, A568, L569, L571
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb c2G4 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: N73, G74, V505, N506, A507, Q508, K510, C511, N512, P513, N514, H549, N550, Q551, D552, G553, C556, G557
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb c2G4 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: N73, G74, V505, N506, A507, Q508, K510, C511, N512, P513, N514, H549, N550, Q551, D552, G553, C556, G557
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb c2G4 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: N73, G74, V505, N506, A507, Q508, K510, C511, N512, P513, N514, H549, N550, Q551, D552, G553, C556, G557
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Low
Host: F 1-2 months

Epitope: Epitope of mAb ADI-15946 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E71, G72, N73, G74, V75, A76, E103, W104, E106, N107, R136, Y137, N506, Q508, P509, K510, C511, N512, P513, N514, H516, E545, L547, H549, N550
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb ADI-15946 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E71, G72, N73, G74, V75, A76, E103, W104, E106, N107, R136, Y137, N506, Q508, P509, K510, C511, N512, P513, N514, H516, E545, L547, H549, N550
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb ADI-15946 on EBOV GP
Chemical type: Discontinuous protein residues
Discontinuous residues: E71, G72, N73, G74, V75, A76, E103, W104, E106, N107, R136, Y137, N506, Q508, P509, K510, C511, N512, P513, N514, H516, E545, L547, H549, N550
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 1-2 months

Epitope: Epitope of mAb ADI-15974 on EBOV GP
Chemical type: Peptide from protein
Sequence: HDWTKNITDKIDQIIHDFVDKTLPD
Position: 613-637
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb ADI-15974 on EBOV GP
Chemical type: Peptide from protein
Sequence: HDWTKNITDKIDQIIHDFVDKTLPD
Position: 613-637
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb ADI-15974 on EBOV GP
Chemical type: Peptide from protein
Sequence: HDWTKNITDKIDQIIHDFVDKTLPD
Position: 613-637
Source molecule (GenBank): Q05320.1
Assay category: BCell
Result: Positive-High
Host: F 1-2 months