Reference: Hayk Davtyan; Karen Zagorski; Irina Petrushina; Konstantin Kazarian; Natalie R S Goldberg; Janet Petrosyan; Mathew Blurton-Jones; Eliezer Masliah; David H Cribbs; Michael G Agadjanyan; Anahit Ghochikyan. "MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency." Neurobiology of aging (2017).

Epitope: alphaSyn 1-20
Chemical type: Peptide from protein
Sequence: MDVFMKGLSKAKEGVVAAAE
Position: 1-20
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 1-20
Chemical type: Peptide from protein
Sequence: MDVFMKGLSKAKEGVVAAAE
Position: 1-20
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 16-35
Chemical type: Peptide from protein
Sequence: VAAAEKTKQGVAEAAGKTKE
Position: 16-35
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 16-35
Chemical type: Peptide from protein
Sequence: VAAAEKTKQGVAEAAGKTKE
Position: 16-35
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 46-65
Chemical type: Peptide from protein
Sequence: EGVVHGVATVAEKTKEQVTN
Position: 46-65
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive-Low
Host: F 6-8 weeks

Epitope: alphaSyn 46-65
Chemical type: Peptide from protein
Sequence: EGVVHGVATVAEKTKEQVTN
Position: 46-65
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 76-95
Chemical type: Peptide from protein
Sequence: AVAQKTVEGAGSIAAATGFV
Position: 76-95
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 76-95
Chemical type: Peptide from protein
Sequence: AVAQKTVEGAGSIAAATGFV
Position: 76-95
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 91-110
Chemical type: Peptide from protein
Sequence: ATGFVKKDQLGKNEEGAPQE
Position: 91-110
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 91-110
Chemical type: Peptide from protein
Sequence: ATGFVKKDQLGKNEEGAPQE
Position: 91-110
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 106-125
Chemical type: Peptide from protein
Sequence: GAPQEGILEDMPVDPDNEAY
Position: 106-125
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive-High
Host: F 6-8 weeks

Epitope: alphaSyn 106-125
Chemical type: Peptide from protein
Sequence: GAPQEGILEDMPVDPDNEAY
Position: 106-125
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 121-140
Chemical type: Peptide from protein
Sequence: DNEAYEMPSEEGYQDYEPEA
Position: 121-140
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 121-140
Chemical type: Peptide from protein
Sequence: DNEAYEMPSEEGYQDYEPEA
Position: 121-140
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive-Low
Host: F 6-8 weeks

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 85-99
Chemical type: Peptide from protein
Sequence: AGSIAAATGFVKKDQ
Position: 85-99
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 109-126
Chemical type: Peptide from protein
Sequence: QEGILEDMPVDPDNEAYE
Position: 109-126
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive-High
Host: F 6-8 weeks

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: alphaSyn 126-140
Chemical type: Peptide from protein
Sequence: EMPSEEGYQDYEPEA
Position: 126-140
Source molecule (GenBank): P37840.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo