Reference: J M Greer; P A Csurhes; K D Cameron; P A McCombe; M F Good; M P Pender. "Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis." Brain : a journal of neurology (1997).

Epitope: PLP<sub>41–58</sub>
Chemical type: Peptide from protein
Sequence: GTEKLIETYFSKNYQDYE
Position: 42-59
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>41–58</sub>
Chemical type: Peptide from protein
Sequence: GTEKLIETYFSKNYQDYE
Position: 42-59
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>95–114</sub>
Chemical type: Peptide from protein
Sequence: AVRQIFGDYKTTICGKGLSA
Position: 96-115
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>95–114</sub>
Chemical type: Peptide from protein
Sequence: AVRQIFGDYKTTICGKGLSA
Position: 96-115
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>100–119</sub>
Chemical type: Peptide from protein
Sequence: FGDYKTTICGKGLSATVTGG
Position: 101-120
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>100–119</sub>
Chemical type: Peptide from protein
Sequence: FGDYKTTICGKGLSATVTGG
Position: 101-120
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>139–151</sub>
Chemical type: Peptide from protein
Sequence: HCLGKWLGHPDKF
Position: 140-152
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>139–151</sub>
Chemical type: Peptide from protein
Sequence: HCLGKWLGHPDKF
Position: 140-152
Source molecule (GenBank): AAA59565.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>178–191</sub>
Chemical type: Peptide from protein
Sequence: NTWTTCQSIAFPSK
Position: 179-192
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>178–191</sub>
Chemical type: Peptide from protein
Sequence: NTWTTCQSIAFPSK
Position: 179-192
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PLP<sub>184–199</sub>
Chemical type: Peptide from protein
Sequence: QSIAFPSKTSASIGSL
Position: 185-200
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PLP<sub>190–209</sub>
Chemical type: Peptide from protein
Sequence: SKTSASIGSLCADARMYGVL
Position: 191-210
Source molecule (GenBank): AAA60117.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: MBP<sub>1-20</sub>
Chemical type: Peptide from protein
Sequence: ASQKRPSQRHGSKYLATAST
Position: 2-21
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>1-20</sub>
Chemical type: Peptide from protein
Sequence: ASQKRPSQRHGSKYLATAST
Position: 2-21
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>11-30</sub>
Chemical type: Peptide from protein
Sequence: GSKYLATASTMDHARHGFLP
Position: 12-31
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>11-30</sub>
Chemical type: Peptide from protein
Sequence: GSKYLATASTMDHARHGFLP
Position: 12-31
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>21-40</sub>
Chemical type: Peptide from protein
Sequence: MDHARHGFLPRHRDTGILDS
Position: 22-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>21-40</sub>
Chemical type: Peptide from protein
Sequence: MDHARHGFLPRHRDTGILDS
Position: 22-41
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>41–60</sub>
Chemical type: Peptide from protein
Sequence: IGRFFGGDRGAPKRGSGKDS
Position: 42-61
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>41–60</sub>
Chemical type: Peptide from protein
Sequence: IGRFFGGDRGAPKRGSGKDS
Position: 42-61
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>49–58</sub> + exon 2<sub>1–10</sub>
Chemical type: Peptide from protein
Sequence: RGAPKRGSGKVPWLKPGRSP
Position: 183-202
Source molecule (GenBank): XP_011524314.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>49–58</sub> + exon 2<sub>1–10</sub>
Chemical type: Peptide from protein
Sequence: RGAPKRGSGKVPWLKPGRSP
Position: 183-202
Source molecule (GenBank): XP_011524314.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP exon 2<sub>1–20</sub>
Chemical type: Peptide from protein
Sequence: VPWLKPGRSPLPSHARSQPG
Position: 193-212
Source molecule (GenBank): XP_011524314.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP exon 2<sub>1–20</sub>
Chemical type: Peptide from protein
Sequence: VPWLKPGRSPLPSHARSQPG
Position: 193-212
Source molecule (GenBank): XP_011524314.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>51–70</sub>
Chemical type: Peptide from protein
Sequence: APKRGSGKDSHHPARTAHYG
Position: 52-71
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>51–70</sub>
Chemical type: Peptide from protein
Sequence: APKRGSGKDSHHPARTAHYG
Position: 52-71
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>61–80</sub>
Chemical type: Peptide from protein
Sequence: HHPARTAHYGSLPQKSHGRT
Position: 62-81
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>61–80</sub>
Chemical type: Peptide from protein
Sequence: HHPARTAHYGSLPQKSHGRT
Position: 62-81
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>71–90</sub>
Chemical type: Peptide from protein
Sequence: SLPQKSHGRTQDENPVVHFF
Position: 72-91
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>71–90</sub>
Chemical type: Peptide from protein
Sequence: SLPQKSHGRTQDENPVVHFF
Position: 72-91
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>91–110</sub>
Chemical type: Peptide from protein
Sequence: KNIVTPRTPPPSQGKGRGLS
Position: 92-111
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>91–110</sub>
Chemical type: Peptide from protein
Sequence: KNIVTPRTPPPSQGKGRGLS
Position: 92-111
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>(96–105) + (117–126)</sub>
Chemical type: Peptide from protein
Sequence: PRTPPPSQGKGAEGQRPGFG
Position: 97-116
Source molecule (GenBank): CAG38771.1
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>(96–105) + (117–126)</sub>
Chemical type: Peptide from protein
Sequence: PRTPPPSQGKGAEGQRPGFG
Position: 97-116
Source molecule (GenBank): CAG38771.1
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>101–120</sub>
Chemical type: Peptide from protein
Sequence: PSQGKGRGLSLSRFSWGAEG
Position: 102-121
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>101–120</sub>
Chemical type: Peptide from protein
Sequence: PSQGKGRGLSLSRFSWGAEG
Position: 102-121
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>111–130</sub>
Chemical type: Peptide from protein
Sequence: LSRFSWGAEGQRPGFGYGGR
Position: 112-131
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>111–130</sub>
Chemical type: Peptide from protein
Sequence: LSRFSWGAEGQRPGFGYGGR
Position: 112-131
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>122–140</sub>
Chemical type: Peptide from protein
Sequence: RPGFGYGGRASDYKSAHKG
Position: 123-141
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>122–140</sub>
Chemical type: Peptide from protein
Sequence: RPGFGYGGRASDYKSAHKG
Position: 123-141
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>131–150</sub>
Chemical type: Peptide from protein
Sequence: ASDYKSAHKGFKGVDAQGTL
Position: 132-151
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>131–150</sub>
Chemical type: Peptide from protein
Sequence: ASDYKSAHKGFKGVDAQGTL
Position: 132-151
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>141–160</sub>
Chemical type: Peptide from protein
Sequence: FKGVDAQGTLSKIFKLGGRD
Position: 142-161
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>141–160</sub>
Chemical type: Peptide from protein
Sequence: FKGVDAQGTLSKIFKLGGRD
Position: 142-161
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>151–170</sub>
Chemical type: Peptide from protein
Sequence: SKIFKLGGRDSRSGSPMARR
Position: 152-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-70 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: MBP<sub>151–170</sub>
Chemical type: Peptide from protein
Sequence: SKIFKLGGRDSRSGSPMARR
Position: 152-171
Source molecule (GenBank): AAH08749.3
Assay category: TCell
Result: Positive
Host:  15-61 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo