Reference: Guo Luo; Jing Zhang; Ling Lin; Emmanuel Jean-Marie Mignot. "Characterization of T cell receptors reactive to HCRT<sub>NH2</sub>, pHA<sub>273-287</sub>, and NP<sub>17-31</sub> in control and narcolepsy patients." Proceedings of the National Academy of Sciences of the United States of America (2022).

Epitope: HA11__pHA41-55
Chemical type: Peptide from protein
Sequence: VTVTHSVNLLEDKHN
Position: 41-55
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA53__pHA209-223
Chemical type: Peptide from protein
Sequence: YQNADAYVFVGSSRY
Position: 209-223
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA66__pHA261-275
Chemical type: Peptide from protein
Sequence: ATGNLVVPRYAFAME
Position: 261-275
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA69__pHA273-287
Chemical type: Peptide from protein
Sequence: AMERNAGSGIIISDT
Position: 273-287
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HA69__pHA273-287
Chemical type: Peptide from protein
Sequence: AMERNAGSGIIISDT
Position: 273-287
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HA69__pHA273-287
Chemical type: Peptide from protein
Sequence: AMERNAGSGIIISDT
Position: 273-287
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HA69__pHA273-287
Chemical type: Peptide from protein
Sequence: AMERNAGSGIIISDT
Position: 273-287
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HA69__pHA273-287
Chemical type: Peptide from protein
Sequence: AMERNAGSGIIISDT
Position: 273-287
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HA81__pHA321-335
Chemical type: Peptide from protein
Sequence: PKYVKSTKLRLATGL
Position: 321-335
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA83__pHA329-343
Chemical type: Peptide from protein
Sequence: LRLATGLRNIPSIQS
Position: 329-343
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HA83__pHA329-343
Chemical type: Peptide from protein
Sequence: LRLATGLRNIPSIQS
Position: 329-343
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA110__pHA437-451
Chemical type: Peptide from protein
Sequence: TYNAELLVLLENERT
Position: 437-451
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HA110__pHA437-451
Chemical type: Peptide from protein
Sequence: TYNAELLVLLENERT
Position: 437-451
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HA131__pHA521-535
Chemical type: Peptide from protein
Sequence: KLESTRIYQILAIYS
Position: 521-535
Source molecule (GenBank): YP_009118626.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: preproHCRT14__HCRT53-67
Chemical type: Peptide from protein
Sequence: LHGAGNHAAGILTLG
Position: 53-67
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: preproHCRT14__HCRT53-67
Chemical type: Peptide from protein
Sequence: LHGAGNHAAGILTLG
Position: 53-67
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: preproHCRT15__HCRT57-71
Chemical type: Peptide from protein
Sequence: GNHAAGILTLGKRRS
Position: 57-71
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: preproHCRT15__HCRT57-71
Chemical type: Peptide from protein
Sequence: GNHAAGILTLGKRRS
Position: 57-71
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HCRT1-8__HCRT54-66-NH2
Chemical type: Peptide from protein
Sequence: HGAGNHAAGILTL
Position: 54-66
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HCRT1-8__HCRT54-66-NH2
Chemical type: Peptide from protein
Sequence: HGAGNHAAGILTL
Position: 54-66
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HCRT1-8__HCRT54-66-NH2
Chemical type: Peptide from protein
Sequence: HGAGNHAAGILTL
Position: 54-66
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HCRT1-12__HCRT55-66-NH2
Chemical type: Peptide from protein
Sequence: GAGNHAAGILTL
Position: 55-66
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HCRT1-12__HCRT55-66-NH2
Chemical type: Peptide from protein
Sequence: GAGNHAAGILTL
Position: 55-66
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HCRT2-6__HCRT86-97-NH2
Chemical type: Peptide from protein
Sequence: ASGNHAAGILTM
Position: 86-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HCRT2-6__HCRT86-97-NH2
Chemical type: Peptide from protein
Sequence: ASGNHAAGILTM
Position: 86-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HCRT2-6__HCRT86-97-NH2
Chemical type: Peptide from protein
Sequence: ASGNHAAGILTM
Position: 86-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HCRT2-13__HCRT85-97-NH2
Chemical type: Peptide from protein
Sequence: QASGNHAAGILTM
Position: 85-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HCRT2-13__HCRT85-97-NH2
Chemical type: Peptide from protein
Sequence: QASGNHAAGILTM
Position: 85-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HCRT2-14__HCRT84-97-NH2
Chemical type: Peptide from protein
Sequence: LQASGNHAAGILTM
Position: 84-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HCRT2-14__HCRT84-97-NH2
Chemical type: Peptide from protein
Sequence: LQASGNHAAGILTM
Position: 84-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: NP23__NP261-275
Chemical type: Peptide from protein
Sequence: RSALILRGSVAHKSC
Position: 261-275
Source molecule (GenBank): AFM72836.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: NP23__NP261-275
Chemical type: Peptide from protein
Sequence: RSALILRGSVAHKSC
Position: 261-275
Source molecule (GenBank): AFM72836.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: NP37__NP17-31-pH1N1
Chemical type: Peptide from protein
Sequence: GERQDATEIRASVGR
Position: 17-31
Source molecule (GenBank): AFM72836.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: NP37__NP17-31-pH1N1
Chemical type: Peptide from protein
Sequence: GERQDATEIRASVGR
Position: 17-31
Source molecule (GenBank): AFM72836.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: NP113__NP437-451-pH1N1
Chemical type: Peptide from protein
Sequence: TSDMRTEVIRMMESA
Position: 437-451
Source molecule (GenBank): AFM72836.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: NP250__NP26-40
Chemical type: Peptide from protein
Sequence: IAPNENMETMESSTL
Position: 26-40
Source molecule (GenBank): CDH98258.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HCRT1FL__HCRT34-66-NH2
Chemical type: Peptide from protein
Sequence: QPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL
Position: 34-66
Source molecule (GenBank): NP_001515.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HCRT2FL__HCRT70-97-NH2
Chemical type: Peptide from protein
Sequence: RSGPPGLQGRLQRLLQASGNHAAGILTM
Position: 70-97
Source molecule (GenBank): O43612.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered