Reference: S Michael Chin; Christopher R Kimberlin; Zygy Roe-Zurz; Pamela Zhang; Allison Xu; Sindy Liao-Chan; Debasish Sen; Andrew R Nager; Nicole Schirle Oakdale; Colleen Brown; Feng Wang; Yuting Yang; Kevin Lindquist; Yik Andy Yeung; Shahram Salek-Ardakani; Javier Chaparro-Riggers. "Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab." Nature communications (2018).

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1400000.0

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.094

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 69.0

Epitope: Epitope of utomilumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: R66, F72, L95, G96, A97, S100, M101, C102, E103, L112, K114, Q128, R130, G131, I132, R134, P135
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.72

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Negative

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 630000.0

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.014

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: Epitope of urelumab on 4-1BB
Chemical type: Discontinuous protein residues
Discontinuous residues: Q25, D26, P27, N30, C31, P32, N39, N40, R41, N42, Q43, I44, C45, R60
Source molecule (GenBank): Q07011.1
Assay category: BCell
Result: Positive
Quantitative measurement: 22.0