Reference: Jia Jia Lim; Claerwen M Jones; Tiing Jen Loh; Hien Thy Dao; Mai T Tran; Jason A Tye-Din; Nicole L La Gruta; Jamie Rossjohn. "A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co-contacting the presented peptide." Nature communications (2025).

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Quantitative measurement: 81400.0
Host: F

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Quantitative measurement: 8100.0
Host: F

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.2
Host: F

Epitope: HLA-DQ2 glia-ω1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQQPFP
Position: 105-115
Source molecule (GenBank): Q9FUW7.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.2

Epitope: CLIP (HLA class II histocompatibility antigen gamma chain peptide)
Chemical type: Peptide from protein
Sequence: ATPLLMQALPMGA
Position: 110-122
Source molecule (GenBank): P04233.3
Assay category: TCell
Result: Positive
Quantitative measurement: 2.45
Host: F

Epitope: CLIP (HLA class II histocompatibility antigen gamma chain peptide)
Chemical type: Peptide from protein
Sequence: ATPLLMQALPMGA
Position: 110-122
Source molecule (GenBank): P04233.3
Assay category: TCell
Result: Positive
Quantitative measurement: 8100.0
Host: F

Epitope: CLIP (HLA class II histocompatibility antigen gamma chain peptide)
Chemical type: Peptide from protein
Sequence: ATPLLMQALPMGA
Position: 110-122
Source molecule (GenBank): P04233.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.45

Epitope: HLA-DQ2 glia-ω2 peptide
Chemical type: Peptide from protein
Sequence: PQPQQPFPWQ
Position: 108-117
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω2 peptide
Chemical type: Peptide from protein
Sequence: PQPQQPFPWQ
Position: 108-117
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Quantitative measurement: 7300.0
Host: F

Epitope: HLA-DQ2 glia-ω2 peptide
Chemical type: Peptide from protein
Sequence: PQPQQPFPWQ
Position: 108-117
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω2 peptide
Chemical type: Peptide from protein
Sequence: PQPQQPFPWQ
Position: 108-117
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-ω2 peptide
Chemical type: Peptide from protein
Sequence: PQPQQPFPWQ
Position: 108-117
Source molecule (GenBank): Q9FUW7.1
Assay category: TCell
Result: Positive
Quantitative measurement: 14500.0
Host: F

Epitope: HLA-DQ2 glut-L1 peptide
Chemical type: Peptide, no natural source
Sequence: QPPASEQEQPVLP
Assay category: TCell
Result: Positive
Quantitative measurement: 2.2
Host: F

Epitope: HLA-DQ2 glut-L1 peptide
Chemical type: Peptide, no natural source
Sequence: QPPASEQEQPVLP
Assay category: TCell
Result: Positive
Quantitative measurement: 12400.0
Host: F

Epitope: HLA-DQ2 glut-L1 peptide
Chemical type: Peptide, no natural source
Sequence: QPPASEQEQPVLP
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.2

Epitope: HLA-DQ2 glia-α1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQLPYP
Position: 60-70
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-α1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQLPYP
Position: 60-70
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-α1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQLPYP
Position: 60-70
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Quantitative measurement: 7400.0
Host: F

Epitope: HLA-DQ2 glia-α1 peptide
Chemical type: Peptide from protein
Sequence: QPFPQPQLPYP
Position: 60-70
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-α2 peptide
Chemical type: Peptide from protein
Sequence: FPQPQLPYPQP
Position: 62-72
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: HLA-DQ2 glia-α2 peptide
Chemical type: Peptide from protein
Sequence: FPQPQLPYPQP
Position: 62-72
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Quantitative measurement: 11900.0
Host: F

Epitope: HLA-DQ2 glia-α2 peptide
Chemical type: Peptide from protein
Sequence: FPQPQLPYPQP
Position: 62-72
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: HLA-DQ8 glia-α1 peptide
Chemical type: Peptide from protein
Sequence: PSGQGSFQPSQQNPQ
Position: 227-241
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: T cell CD3+
Tissue: kidney
Culture conditions: Engineered