Reference: Yufei Xiang; Jialu Xu; Briana L McGovern; Anna Ranzenigo; Wei Huang; Zhe Sang; Juan Shen; Randy Diaz-Tapia; Ngoc Dung Pham; Abraham J P Teunissen; M Luis Rodriguez; Jared Benjamin; Derek J Taylor; Mandy M T van Leent; Kris M White; Adolfo García-Sastre; Peijun Zhang; Yi Shi. "Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral therapy." Cell (2024).

Epitope: Epitope I mAb 182 (2-67)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, A475, G476, S477, V483, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope I mAb 182 (2-67)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, A475, G476, S477, V483, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope I mAb 182 (2-67)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, A475, G476, S477, V483, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 35 (2-34)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, G476, V483, E484, G485, F486, N487, C488, Y489, F490, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 35 (2-34)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, G476, V483, E484, G485, F486, N487, C488, Y489, F490, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 35 (2-34)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, G476, V483, E484, G485, F486, N487, C488, Y489, F490, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 35 (2-34)
Chemical type: Discontinuous protein residues
Discontinuous residues: F456, G476, V483, E484, G485, F486, N487, C488, Y489, F490, Q493
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 38 (2-38)
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, T376, K378, C379, Y380, G381, V382, S383, T385, K386, R408, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 38 (2-38)
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, T376, K378, C379, Y380, G381, V382, S383, T385, K386, R408, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 38 (2-38)
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, T376, K378, C379, Y380, G381, V382, S383, T385, K386, R408, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 38 (2-38)
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, T376, K378, C379, Y380, G381, V382, S383, T385, K386, R408, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope II mAb 118 (2-31)
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S375, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, A411, P412, G413, Q414, D427, D428
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope III mAb 93 (2-10)
Chemical type: Discontinuous protein residues
Discontinuous residues: N354, R355, K356, R357, S359, F464, E465, R466, D467, I468, S469
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope III mAb 93 (2-10)
Chemical type: Discontinuous protein residues
Discontinuous residues: N354, R355, K356, R357, S359, F464, E465, R466, D467, I468, S469
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 113 (1-22)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, S383, K386, L390, P426, D427, D428, T430, P463, F464, E516, L517, L518, H519
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 132 (2-45)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F464, S514, F515, E516, L517, L518, H519, A520, P521, A522
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 179 (2-65)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F515, E516, L517, L518, H519, A520
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope IV & V mAb 179 (2-65)
Chemical type: Discontinuous protein residues
Discontinuous residues: G381, V382, K386, L390, D428, F429, T430, F515, E516, L517, L518, H519, A520
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive