Reference: Ryan W Nelson; Yuezhou Chen; Olivia L Venezia; Richard M Majerus; Daniel S Shin; Mary N Carrington; Xu G Yu; Duane R Wesemann; James J Moon; Andrew D Luster. "SARS-CoV-2 epitope-specific CD4<sup>+</sup> memory T cell responses across COVID-19 disease severity and antibody durability." Science immunology (2022).

Epitope: TRFQTLLALHRS
Chemical type: Peptide from protein
Sequence: TRFQTLLALHRS
Position: 236-247
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TRFQTLLALHRS
Chemical type: Peptide from protein
Sequence: TRFQTLLALHRS
Position: 236-247
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IPFAMQMAYRF
Chemical type: Peptide from protein
Sequence: IPFAMQMAYRF
Position: 896-906
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IPFAMQMAYRF
Chemical type: Peptide from protein
Sequence: IPFAMQMAYRF
Position: 896-906
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: AEIRASANLAA
Chemical type: Peptide from protein
Sequence: AEIRASANLAA
Position: 1016-1026
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: AEIRASANLAA
Chemical type: Peptide from protein
Sequence: AEIRASANLAA
Position: 1016-1026
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: INLVRDLPQGFS
Chemical type: Peptide from protein
Sequence: INLVRDLPQGFS
Position: 210-221
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SQILPDPSKPSK
Chemical type: Peptide from protein
Sequence: SQILPDPSKPSK
Position: 803-814
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: RSFIEDLLFNKV
Chemical type: Peptide from protein
Sequence: RSFIEDLLFNKV
Position: 815-826
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IPFAMQMAYRFNG
Chemical type: Peptide from protein
Sequence: IPFAMQMAYRFNG
Position: 896-908
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GVYYPDKVFRSS
Chemical type: Peptide from protein
Sequence: GVYYPDKVFRSS
Position: 35-46
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: RGWIFGTTLDSKT
Chemical type: Peptide from protein
Sequence: RGWIFGTTLDSKT
Position: 102-114
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SNFRVQPTESIV
Chemical type: Peptide from protein
Sequence: SNFRVQPTESIV
Position: 316-327
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GEVFNATRFASV
Chemical type: Peptide from protein
Sequence: GEVFNATRFASV
Position: 339-350
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: YNYLYRLFRKSN
Chemical type: Peptide from protein
Sequence: YNYLYRLFRKSN
Position: 449-460
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: QALNTLVKQLS
Chemical type: Peptide from protein
Sequence: QALNTLVKQLS
Position: 957-967
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: YLYRLFRKSNL
Chemical type: Peptide from protein
Sequence: YLYRLFRKSNL
Position: 451-461
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DGYFKIYSKHT
Chemical type: Peptide from protein
Sequence: DGYFKIYSKHT
Position: 198-208
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: QTLLALHRSYL
Chemical type: Peptide from protein
Sequence: QTLLALHRSYL
Position: 239-249
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: EMIAQYTSALLA
Chemical type: Peptide from protein
Sequence: EMIAQYTSALLA
Position: 868-879
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SAFFGMSRIGME
Chemical type: Peptide from protein
Sequence: SAFFGMSRIGME
Position: 312-323
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SAFFGMSRIGME
Chemical type: Peptide from protein
Sequence: SAFFGMSRIGME
Position: 312-323
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TWLTYTGAIKLD
Chemical type: Peptide from protein
Sequence: TWLTYTGAIKLD
Position: 329-340
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ALLLLDRLNQLE
Chemical type: Peptide from protein
Sequence: ALLLLDRLNQLE
Position: 220-231
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ASWFTALTQHGK
Chemical type: Peptide from protein
Sequence: ASWFTALTQHGK
Position: 50-61
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: WYFYYLGTGPEA
Chemical type: Peptide from protein
Sequence: WYFYYLGTGPEA
Position: 108-119
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAFFG
Position: 305-316
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAFFG
Position: 305-316
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAFFG
Position: 305-316
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAFFG
Position: 305-316
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N329
Chemical type: Peptide from protein
Sequence: TWLTYTGAIKLD
Position: 329-340
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N329
Chemical type: Peptide from protein
Sequence: TWLTYTGAIKLD
Position: 329-340
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N329
Chemical type: Peptide from protein
Sequence: TWLTYTGAIKLD
Position: 329-340
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DR7:N329
Chemical type: Peptide from protein
Sequence: TWLTYTGAIKLD
Position: 329-340
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GYYRRATRRIRG
Chemical type: Peptide from protein
Sequence: GYYRRATRRIRG
Position: 85-96
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DQVILLNKHIDA
Chemical type: Peptide from protein
Sequence: DQVILLNKHIDA
Position: 348-359
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GTWLTYTGAIKL
Chemical type: Peptide from protein
Sequence: GTWLTYTGAIKL
Position: 328-339
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KHIDAYKTFPPT
Chemical type: Peptide from protein
Sequence: KHIDAYKTFPPT
Position: 355-366
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo