Reference: Brett Robison; S J Diong; Anusha Kumar; Thomas M Moon; Olin Chang; Bryant Chau; Christine Bee; Ishita Barman; Arvind Rajpal; Alan J Korman; Sean West; Pavel Strop; Peter S Lee. "Engineered ipilimumab variants that bind human and mouse CTLA-4." mAbs (2025).

Epitope: Epitope of Fab 9D9 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: E36, A37, P62, H64, N65, D67, E68, T90, E91, Y135, P136, P137, P138, Y139, F140
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0319

Epitope: Epitope of Fab 9D9 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: E36, A37, P62, H64, N65, D67, E68, T90, E91, Y135, P136, P137, P138, Y139, F140
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 3.1

Epitope: Epitope of Fab 9D9 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: E36, A37, P62, H64, N65, D67, E68, T90, E91, Y135, P136, P137, P138, Y139, F140
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 87.4

Epitope: Epitope of Fab 9D9 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: E36, A37, P62, H64, N65, D67, E68, T90, E91, Y135, P136, P137, P138, Y139, F140
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 367000.0

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 0.231

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000143

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 661000.0

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00117

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 673000.0

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 1.57

Epitope: Epitope of Fab mipi.4 on mCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: I38, Q39, E68, R70, L74, M81, E83, T88, Y100, K130, E132, M134, Y135, P138, Y139, F140, V141, G142, M143
Source molecule (GenBank): P09793
Assay category: BCell
Result: Positive
Quantitative measurement: 1.76

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 661000.0

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 1.76

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00117

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 673000.0

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 1.64

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.231

Epitope: Epitope of Fab mipi.4 on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: M38, H39, E68, R70, L74, V81, E83, K130, E132, M134, Y135, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000143

Epitope: Epitope of ipilimumab on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: K36, M38, E68, R70, L74, S79, V81, T82, E83, K130, E132, M134, Y135, P136, P137, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 317000.0

Epitope: Epitope of ipilimumab on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: K36, M38, E68, R70, L74, S79, V81, T82, E83, K130, E132, M134, Y135, P136, P137, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0206

Epitope: Epitope of ipilimumab on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: K36, M38, E68, R70, L74, S79, V81, T82, E83, K130, E132, M134, Y135, P136, P137, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive
Quantitative measurement: 64.9

Epitope: Epitope of ipilimumab on hCTLA4
Chemical type: Discontinuous protein residues
Discontinuous residues: K36, M38, E68, R70, L74, S79, V81, T82, E83, K130, E132, M134, Y135, P136, P137, P138, Y139, Y140, L141, G142, I143
Source molecule (GenBank): P16410.3
Assay category: BCell
Result: Positive