Reference: Ronit Mazor; Aaron N Vassall; Jaime A Eberle; Richard Beers; John E Weldon; David J Venzon; Kwong Y Tsang; Itai Benhar; Ira Pastan. "Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A." Proceedings of the National Academy of Sciences of the United States of America (2012).

Epitope: P11
Chemical type: Peptide from protein
Sequence: EQLEQCGYPVQRLVA
Position: 282-296
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P12
Chemical type: Peptide from protein
Sequence: EQCGYPVQRLVALYL
Position: 285-299
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P14
Chemical type: Peptide from protein
Sequence: VQRLVALYLAARLSW
Position: 291-305
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P15
Chemical type: Peptide from protein
Sequence: LVALYLAARLSWNQV
Position: 294-308
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P16
Chemical type: Peptide from protein
Sequence: LYLAARLSWNQVDQV
Position: 297-311
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P17
Chemical type: Peptide from protein
Sequence: AARLSWNQVDQVIRN
Position: 300-314
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P18
Chemical type: Peptide from protein
Sequence: LSWNQVDQVIRNALA
Position: 303-317
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P20
Chemical type: Peptide from protein
Sequence: DQVIRNALASPGSGG
Position: 309-323
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P21
Chemical type: Peptide from protein
Sequence: IRNALASPGSGGDLG
Position: 312-326
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P22
Chemical type: Peptide from protein
Sequence: ALASPGSGGDLGEAI
Position: 315-329
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P24
Chemical type: Peptide from protein
Sequence: SGGDLGEAIREQPEQ
Position: 321-335
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P25
Chemical type: Peptide from protein
Sequence: DLGEAIREQPEQARL
Position: 324-338
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P62
Chemical type: Peptide from protein
Sequence: VFGGVRARSQDLDAI
Position: 451-465
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P63
Chemical type: Peptide from protein
Sequence: GVRARSQDLDAIWRG
Position: 454-468
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P64
Chemical type: Peptide from protein
Sequence: ARSQDLDAIWRGFYI
Position: 457-471
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P65
Chemical type: Peptide from protein
Sequence: QDLDAIWRGFYIAGD
Position: 460-474
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P101
Chemical type: Peptide from protein
Sequence: PSAIPTDPRNVGGDL
Position: 568-582
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P102
Chemical type: Peptide from protein
Sequence: IPTDPRNVGGDLDPS
Position: 571-585
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P103
Chemical type: Peptide from protein
Sequence: DPRNVGGDLDPSSIP
Position: 574-588
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P104
Chemical type: Peptide from protein
Sequence: NVGGDLDPSSIPDKE
Position: 577-591
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P106
Chemical type: Peptide from protein
Sequence: DPSSIPDKEQAISAL
Position: 583-597
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P107
Chemical type: Peptide from protein
Sequence: SIPDKEQAISALPDY
Position: 586-600
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P108
Chemical type: Peptide from protein
Sequence: DKEQAISALPDYASQ
Position: 589-603
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P109
Chemical type: Peptide from protein
Sequence: QAISALPDYASQPGK
Position: 592-606
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P110
Chemical type: Peptide from protein
Sequence: SALPDYASQPGKPPR
Position: 595-609
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P111
Chemical type: Peptide from protein
Sequence: PDYASQPGKPPREDL
Position: 598-612
Source molecule (GenBank): 1IKQ_A
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L294A
Chemical type: Peptide, no natural source
Sequence: AVALYLAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: V295A
Chemical type: Peptide, no natural source
Sequence: LAALYLAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A496G
Chemical type: Peptide, no natural source
Sequence: LVGLYLAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L297A
Chemical type: Peptide, no natural source
Sequence: LVAAYLAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Y298A
Chemical type: Peptide, no natural source
Sequence: LVALALAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L299A
Chemical type: Peptide, no natural source
Sequence: LVALYAAARLSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A300G
Chemical type: Peptide, no natural source
Sequence: LVALYLGARLSWNQV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A301G
Chemical type: Peptide, no natural source
Sequence: LVALYLAGRLSWNQV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: R302A
Chemical type: Peptide, no natural source
Sequence: LVALYLAAALSWNQV
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L303A
Chemical type: Peptide, no natural source
Sequence: LVALYLAARASWNQV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S304A
Chemical type: Peptide, no natural source
Sequence: LVALYLAARLAWNQV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: W305A
Chemical type: Peptide, no natural source
Sequence: LVALYLAARLSANQV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated