Reference: Rocky L Baker; Marynette Rihanek; Anita C Hohenstein; Maki Nakayama; Aaron Michels; Peter A Gottlieb; Kathryn Haskins; Thomas Delong. "Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes." Diabetes (2019).

Epitope: HIP1
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP1
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP1
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP2
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP2
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP2
Chemical type: Spliced peptide from proteins
Position: 64-70
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP3
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP3
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP3
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP4
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP4
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP4
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP5
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP5
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP5
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP6
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP6
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP6
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP7
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP7
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP7
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP8
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP8
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP8
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP9
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP9
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP9
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP10
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP10
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP10
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP11
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP11
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP11
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host: M 12 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP11
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP11
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host: M 12 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP12
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP12
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP12
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host: M 12 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP12
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host: M 12 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP12
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP13
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP13
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP13
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP15
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP15
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP15
Chemical type: Spliced peptide from proteins
Position: 76-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ins 64–79
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQP
Position: 64-79
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ins 64–79
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQP
Position: 64-79
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ins 75–90
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSLQKRG
Position: 75-90
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ins 75–90
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSLQKRG
Position: 75-90
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ChgA 334–349
Chemical type: Peptide from protein
Sequence: KEWEDSKRWSKMDQLA
Position: 334-349
Source molecule (GenBank): P10645.7
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ChgA 334–349
Chemical type: Peptide from protein
Sequence: KEWEDSKRWSKMDQLA
Position: 334-349
Source molecule (GenBank): P10645.7
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ChgA 350–365
Chemical type: Peptide from protein
Sequence: KELTAEKRLEGQEEEE
Position: 350-365
Source molecule (GenBank): P10645.7
Assay category: TCell
Result: Positive-Low
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ChgA 350–365
Chemical type: Peptide from protein
Sequence: KELTAEKRLEGQEEEE
Position: 350-365
Source molecule (GenBank): P10645.7
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Ins 49–64
Chemical type: Peptide from protein
Sequence: FYTPKTRREAEDLQVG
Position: 49-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Ins 49–64
Chemical type: Peptide from protein
Sequence: FYTPKTRREAEDLQVG
Position: 49-64
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IAPP 15–30
Chemical type: Peptide from protein
Sequence: VALNHLKATPIESHQV
Position: 15-30
Source molecule (GenBank): CAA39504.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IAPP 15–30
Chemical type: Peptide from protein
Sequence: VALNHLKATPIESHQV
Position: 15-30
Source molecule (GenBank): CAA39504.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IAPP 66–81
Chemical type: Peptide from protein
Sequence: GSNTYGKRNAVEVLKR
Position: 66-81
Source molecule (GenBank): CAA39504.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IAPP 66–81
Chemical type: Peptide from protein
Sequence: GSNTYGKRNAVEVLKR
Position: 66-81
Source molecule (GenBank): CAA39504.1
Assay category: TCell
Result: Positive
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ScG1 432–447
Chemical type: Peptide from protein
Sequence: SDTREEKRFLGEGHHR
Position: 466-481
Source molecule (GenBank): BAD92949.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ScG1 432–447
Chemical type: Peptide from protein
Sequence: SDTREEKRFLGEGHHR
Position: 466-481
Source molecule (GenBank): BAD92949.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NP-Y 60–75
Chemical type: Peptide from protein
Sequence: TRQRYGKRSSPETLIS
Position: 60-75
Source molecule (GenBank): P01303.1
Assay category: TCell
Result: Positive
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NP-Y 60–75
Chemical type: Peptide from protein
Sequence: TRQRYGKRSSPETLIS
Position: 60-75
Source molecule (GenBank): P01303.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: insB:9-23R22E
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEE
Assay category: TCell
Result: Positive-Low
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: insB:9-23R22E
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEE
Assay category: TCell
Result: Positive-Low
Host: M 12 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: insB:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGER
Position: 33-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  5-19 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: insB:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGER
Position: 33-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  7-35 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo