Reference: Sabine Costagliola; Marco Bonomi; Nils G Morgenthaler; Joost Van Durme; Valérie Panneels; Samuel Refetoff; Gilbert Vassart. "Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity." Molecular endocrinology (Baltimore, Md.) (2004).

Epitope: mAb IR1-SAb1 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: Q51, Q97
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive-Low

Epitope: mAb IR1-SAb1 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: Q51, Q97
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive

Epitope: mAb IR1-SAb1 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: Q51, Q97
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Quantitative measurement: 20.0

Epitope: mAb IR1-SAb1 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: Q51, Q97
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive-Low
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive

Epitope: mAb IRI-SAb2 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, I66, R86, Y88, I91,H111, E113, R115
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.07
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.28
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IRI-SAb3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: I66, E67, Y88, I91, E113, R115, F136, G138, F140, E163, K189
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Host: F 6 weeks

Epitope: mAb IH7 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, R86, Y88, R115, F136, G138, F140
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive

Epitope: mAb IH7 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, R86, Y88, R115, F136, G138, F140
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive

Epitope: mAb IH7 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, R86, Y88, R115, F136, G138, F140
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.12

Epitope: mAb IH7 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T62, K64, R86, Y88, R115, F136, G138, F140
Source molecule (GenBank): BAD92444.1
Assay category: BCell
Result: Positive