Reference: Hebang Yao; Hongyang Wang; Zhaoyong Zhang; Yuchi Lu; Zhiying Zhang; Yu Zhang; Xinyi Xiong; Yanqun Wang; Zhizhi Wang; Haitao Yang; Jincun Zhao; Wenqing Xu. "A potent and broad-spectrum neutralizing nanobody for SARS-CoV-2 viruses, including all major Omicron strains." MedComm (2023).

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.43

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 94000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 7.65

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00027

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 35000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 52000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00017

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 51000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00026

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 27000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00000010

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.2

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.2

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00012

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000016

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.68

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive
Quantitative measurement: 24000.0

Epitope: Epitope of Nb4 on Omicron BA.1 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, F374, F375, T376, F377, K378, S383, P384, T385, G404, R408, A435, Y501, G502, V503, G504, Q506, Y508
Source molecule (GenBank): UJU86738.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 27000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.2

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00012

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 52000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.2

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00017

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 51000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 35000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.68

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000016

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 24000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00000010

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 7.65

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00027

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.43

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 94000.0

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00026

Epitope: Epitope of Nb4 on Omicron BA.5 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, P373, F374, F375, A376, F377, K378, P384, T385, G404, N405, V407, V503, G504, Q506, Y508
Source molecule (GenBank): UUB67338.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8