Reference: Nikolai N Sluchanko; Irina V Sokolova; Irina A Favorskaya; Ilias B Esmagambetov; Amir I Tukhvatulin; Irina A Alekseeva; Anastasiya S Ungur; Larisa A Varfolomeeva; Konstantin M Boyko; Denis Y Logunov; Alexander L Gintsburg; Vladimir O Popov; Dmitry V Shcheblyakov; Yury F Belyi. "Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain." International journal of biological macromolecules (2024).

Epitope: Epitope of nanobody H5.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: Y2655, W2666, Q2667, T2668, I2669, N2670, G2671, K2672, V2673, Y2696, K2704, P2706, G2707
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.65

Epitope: Epitope of nanobody H5.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: Y2655, W2666, Q2667, T2668, I2669, N2670, G2671, K2672, V2673, Y2696, K2704, P2706, G2707
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of nanobody H5.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: Y2655, W2666, Q2667, T2668, I2669, N2670, G2671, K2672, V2673, Y2696, K2704, P2706, G2707
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody H5.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: Y2655, W2666, Q2667, T2668, I2669, N2670, G2671, K2672, V2673, Y2696, K2704, P2706, G2707
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody H5.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: Y2655, W2666, Q2667, T2668, I2669, N2670, G2671, K2672, V2673, Y2696, K2704, P2706, G2707
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.1

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-High

Epitope: Epitope of nanobody C4.2 on C. difficile toxin A CROPs domain
Chemical type: Discontinuous protein residues
Discontinuous residues: N2644, Y2655, N2658, T2664, G2665, W2666, Q2667, T2668, I2669, N2670, G2671
Source molecule (GenBank): P16154.2
Assay category: BCell
Result: Positive-Low