Reference: David A Ostrov; Aimon Alkanani; Kristen A McDaniel; Stephanie Case; Erin E Baschal; Laura Pyle; Sam Ellis; Bernadette Pöllinger; Katherine J Seidl; Viral N Shah; Satish K Garg; Mark A Atkinson; Peter A Gottlieb; Aaron W Michels. "Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes." The Journal of clinical investigation (2018).

Epitope: Insulin B:13-23
Chemical type: Peptide from protein
Sequence: EALYLVCGERG
Position: 37-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host: M 18 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: α-methyldopa
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3400.0

Epitope: α-methyldopa ethyl ester
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 5800.0

Epitope: α-methylphenylalanine
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: α-methyltyrosine
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: 3-O-methyl methyldopa
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: α-methylnorepinephrine
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-169091
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-50381
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-65644
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-292267
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-113595
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-62786
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-8704
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-118368
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive

Epitope: NSC-61560
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-25693
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-270295
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-9231
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-27421
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-66259
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-602670
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-44627
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-163039
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-120375
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-612049
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-60718
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-304467
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-620753
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-102816
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-7652
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-281272
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-406087
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-34652
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-474
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-63878
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-169108
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-110364
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: NSC-3074
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Negative

Epitope: alpha gliadin 228-240 (deamidated)
Chemical type: Peptide from protein
Sequence: SGQGSFQPSQQNP
Position: 228-240
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: gastrointestinal tract
Culture conditions: Cell Line / Clone

Epitope: Insulin B:13-23 B22E
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  18-48 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TT 922-941
Chemical type: Peptide from protein
Sequence: AIHLVNNESSEVIVHKAMDI
Position: 922-941
Source molecule (GenBank): P04958.2
Assay category: TCell
Result: Positive
Host:  18-48 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TATD
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: TATD
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 80.0