Reference: Stephen Man; James E Redman; Deborah L Cross; David K Cole; Ilona Can; Bethan Davies; Shaikh Shimaz Hashimdeen; Reiss Reid; Sian Llewellyn-Lacey; Kelly L Miners; Kristin Ladell; Anya Lissina; Paul E Brown; Linda Wooldridge; David A Price; Pierre J Rizkallah. "Synthetic Peptides with Inadvertent Chemical Modifications Can Activate Potentially Autoreactive T Cells." Journal of immunology (Baltimore, Md. : 1950) (2021).

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.68

Epitope: 3-tBu-Y
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: MhcBinding
Result: Positive-Low

Epitope: LLSY-Me
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPT
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.01

Epitope: 6C5 predicted optimal
Chemical type: Peptide, no natural source
Sequence: IIGWMWIPV
Assay category: MhcBinding
Result: Positive

Epitope: Viral Candidate 2
Chemical type: Peptide from protein
Sequence: VLGYIGATV
Position: 3927-3935
Source molecule (GenBank): AGT21344.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 2
Chemical type: Peptide from protein
Sequence: FLAWGGVPL
Position: 1771-1779
Source molecule (GenBank): Q8TEP8.3
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 3
Chemical type: Peptide from protein
Sequence: VLAWGLLNV
Position: 29-37
Source molecule (GenBank): Q96SK2.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 4
Chemical type: Peptide from protein
Sequence: IMAWGLATL
Position: 159-167
Source molecule (GenBank): P51810.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 5
Chemical type: Peptide from protein
Sequence: YTAYVFIPI
Position: 47-55
Source molecule (GenBank): Q8NFR3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 5
Chemical type: Peptide from protein
Sequence: YTAYVFIPI
Position: 47-55
Source molecule (GenBank): Q8NFR3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 5
Chemical type: Peptide from protein
Sequence: YTAYVFIPI
Position: 47-55
Source molecule (GenBank): Q8NFR3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 5
Chemical type: Peptide from protein
Sequence: YTAYVFIPI
Position: 47-55
Source molecule (GenBank): Q8NFR3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 5
Chemical type: Peptide from protein
Sequence: YTAYVFIPI
Position: 47-55
Source molecule (GenBank): Q8NFR3.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 6
Chemical type: Peptide from protein
Sequence: LLGWMLSQV
Position: 308-316
Source molecule (GenBank): Q7RTR2.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 8
Chemical type: Peptide from protein
Sequence: MLAWIFLPI
Position: 111-119
Source molecule (GenBank): Q8WWX8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 8
Chemical type: Peptide from protein
Sequence: MLAWIFLPI
Position: 111-119
Source molecule (GenBank): Q8WWX8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 8
Chemical type: Peptide from protein
Sequence: MLAWIFLPI
Position: 111-119
Source molecule (GenBank): Q8WWX8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 8
Chemical type: Peptide from protein
Sequence: MLAWIFLPI
Position: 111-119
Source molecule (GenBank): Q8WWX8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 8
Chemical type: Peptide from protein
Sequence: MLAWIFLPI
Position: 111-119
Source molecule (GenBank): Q8WWX8.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 9
Chemical type: Peptide from protein
Sequence: YMAYMFLTL
Position: 551-559
Source molecule (GenBank): P30531.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 10
Chemical type: Peptide from protein
Sequence: MTAWILLPV
Position: 1-9
Source molecule (GenBank): Q86TG1.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 11
Chemical type: Peptide from protein
Sequence: LLGWLFAPV
Position: 108-116
Source molecule (GenBank): NP_003032.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 13
Chemical type: Peptide from protein
Sequence: IIWYYFPSA
Position: 24-32
Source molecule (GenBank): NP_001159445.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 15
Chemical type: Peptide from protein
Sequence: LIGWGLPTV
Position: 246-254
Source molecule (GenBank): P41587.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.7

Epitope: Self Candidate 16
Chemical type: Peptide from protein
Sequence: LLGWVFAQV
Position: 21-29
Source molecule (GenBank): P13726.1
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 17
Chemical type: Peptide from protein
Sequence: LLGWVFIPI
Position: 92-100
Source molecule (GenBank): P53794.2
Assay category: MhcBinding
Result: Positive

Epitope: Self Candidate 18
Chemical type: Peptide from protein
Sequence: ILGWIFVPI
Position: 111-119
Source molecule (GenBank): Q9NY91.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 18
Chemical type: Peptide from protein
Sequence: ILGWIFVPI
Position: 111-119
Source molecule (GenBank): Q9NY91.1
Assay category: MhcBinding
Result: Positive

Epitope: Viral Candidate 3
Chemical type: Peptide from protein
Sequence: LLGYVLART
Position: 194-202
Source molecule (GenBank): AHJ84212.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 4
Chemical type: Peptide from protein
Sequence: FLARFWTRA
Position: 206-214
Source molecule (GenBank): AQZ56917.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 5
Chemical type: Peptide from protein
Sequence: FTSYGFSNV
Position: 519-527
Source molecule (GenBank): AGW80932.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 6
Chemical type: Peptide from protein
Sequence: ITAYGLVLV
Position: 16-24
Source molecule (GenBank): ADM22530.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 7
Chemical type: Peptide from protein
Sequence: LTAYMLLAI
Position: 25-33
Source molecule (GenBank): YP_081570.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 8
Chemical type: Peptide from protein
Sequence: IVAWFLLLI
Position: 2-10
Source molecule (GenBank): A0A0K2YSH1.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 9
Chemical type: Peptide from protein
Sequence: FIGYMVKNV
Position: 214-222
Source molecule (GenBank): YP_233000.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 10
Chemical type: Peptide from protein
Sequence: ILGHCWVTA
Position: 15-23
Source molecule (GenBank): BAV17906.1
Assay category: MhcBinding
Result: Negative

Epitope: Viral Candidate 11
Chemical type: Peptide from protein
Sequence: LLFYMWSGT
Position: 222-230
Source molecule (GenBank): BAA78257.1
Assay category: MhcBinding
Result: Negative

Epitope: Self Candidate 19
Chemical type: Peptide from protein
Sequence: FLAYFLVSI
Position: 9-17
Source molecule (GenBank): O94766.2
Assay category: MhcBinding
Result: Negative

Epitope: Self Candidate 21
Chemical type: Peptide from protein
Sequence: LLGYGWAAA
Position: 66-74
Source molecule (GenBank): Q86UE4.2
Assay category: MhcBinding
Result: Negative

Epitope: Self Candidate 22
Chemical type: Peptide from protein
Sequence: LLAWHFVAV
Position: 353-361
Source molecule (GenBank): Q8N3P4.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 22
Chemical type: Peptide from protein
Sequence: LLAWHFVAV
Position: 353-361
Source molecule (GenBank): Q8N3P4.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 22
Chemical type: Peptide from protein
Sequence: LLAWHFVAV
Position: 353-361
Source molecule (GenBank): Q8N3P4.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 22
Chemical type: Peptide from protein
Sequence: LLAWHFVAV
Position: 353-361
Source molecule (GenBank): Q8N3P4.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Self Candidate 22
Chemical type: Peptide from protein
Sequence: LLAWHFVAV
Position: 353-361
Source molecule (GenBank): Q8N3P4.3
Assay category: MhcBinding
Result: Positive-Low

Epitope: Self Candidate 23
Chemical type: Peptide from protein
Sequence: FLAYSGIPA
Position: 544-552
Source molecule (GenBank): P02786.2
Assay category: MhcBinding
Result: Negative

Epitope: Self Candidate 24
Chemical type: Peptide from protein
Sequence: LMGYSFAAV
Position: 218-226
Source molecule (GenBank): Q8WWX8.1
Assay category: MhcBinding
Result: Negative

Epitope: Self Candidate 25
Chemical type: Peptide from protein
Sequence: YVAWFLVFA
Position: 1578-1586
Source molecule (GenBank): Q9NTG1.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Modified 1
Chemical type: Peptide, no natural source
Sequence: LLSWFGTPT
Assay category: MhcBinding
Result: Negative

Epitope: Modified 3
Chemical type: Peptide, no natural source
Sequence: LLSYFGTPV
Assay category: MhcBinding
Result: Negative