Reference: Patrick Koenig; Chingwei V Lee; Sarah Sanowar; Ping Wu; Jeremy Stinson; Seth F Harris; Germaine Fuh. "Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration." The Journal of biological chemistry (2015).

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on Ang2
Chemical type: Discontinuous protein residues
Discontinuous residues: K432, C433, I434, C435, L441, D448, A449, C450, G451, P452, F469, Y475, Y476, S480
Source molecule (GenBank): O15123.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1130000.0

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on Ang2
Chemical type: Discontinuous protein residues
Discontinuous residues: K432, C433, I434, C435, L441, D448, A449, C450, G451, P452, F469, Y475, Y476, S480
Source molecule (GenBank): O15123.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00615

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on Ang2
Chemical type: Discontinuous protein residues
Discontinuous residues: K432, C433, I434, C435, L441, D448, A449, C450, G451, P452, F469, Y475, Y476, S480
Source molecule (GenBank): O15123.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on Ang2
Chemical type: Discontinuous protein residues
Discontinuous residues: K432, C433, I434, C435, L441, D448, A449, C450, G451, P452, F469, Y475, Y476, S480
Source molecule (GenBank): O15123.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.0

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on Ang2
Chemical type: Discontinuous protein residues
Discontinuous residues: K432, C433, I434, C435, L441, D448, A449, C450, G451, P452, F469, Y475, Y476, S480
Source molecule (GenBank): O15123.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.27

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on VEGF
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K74, M107, I109, K110, P111, H112, Q113, G114, Q115, H116, I117; D: M44, Y47, Q48, Y51, N88, D89, G91, L92, P132
Source molecule (GenBank): P15692.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0017

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on VEGF
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K74, M107, I109, K110, P111, H112, Q113, G114, Q115, H116, I117; D: M44, Y47, Q48, Y51, N88, D89, G91, L92, P132
Source molecule (GenBank): P15692.2
Assay category: BCell
Result: Positive

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on VEGF
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K74, M107, I109, K110, P111, H112, Q113, G114, Q115, H116, I117; D: M44, Y47, Q48, Y51, N88, D89, G91, L92, P132
Source molecule (GenBank): P15692.2
Assay category: BCell
Result: Positive
Quantitative measurement: 5.0

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on VEGF
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K74, M107, I109, K110, P111, H112, Q113, G114, Q115, H116, I117; D: M44, Y47, Q48, Y51, N88, D89, G91, L92, P132
Source molecule (GenBank): P15692.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.75

Epitope: Epitope of Dual Action Fab (DAF) 5A12 on VEGF
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K74, M107, I109, K110, P111, H112, Q113, G114, Q115, H116, I117; D: M44, Y47, Q48, Y51, N88, D89, G91, L92, P132
Source molecule (GenBank): P15692.2
Assay category: BCell
Result: Positive
Quantitative measurement: 333000.0