Reference: Halina Mikolajek; Miriam Weckener; Z Faidon Brotzakis; Jiandong Huo; Evmorfia V Dalietou; Audrey Le Bas; Pietro Sormanni; Peter J Harrison; Philip N Ward; Steven Truong; Lucile Moynie; Daniel K Clare; Maud Dumoux; Joshua Dormon; Chelsea Norman; Naveed Hussain; Vinod Vogirala; Raymond J Owens; Michele Vendruscolo; James H Naismith. "Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes." Proceedings of the National Academy of Sciences of the United States of America (2022).

Epitope: Epitope of VHH H11 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: K444, G446, G447, Y449, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: K444, G446, G447, Y449, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 930.0

Epitope: Epitope of VHH H11 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: K444, G446, G447, Y449, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 820.0

Epitope: Epitope of VHH H11 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: K444, G446, G447, Y449, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.59

Epitope: Epitope of VHH F2 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, P412, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.9

Epitope: Epitope of VHH F2 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, P412, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.59

Epitope: Epitope of VHH F2 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, G381, V382, S383, P384, T385, R408, P412, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 9.2

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5900000.0

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.055

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 60.0

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11-A10 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 53.0

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 8.8

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5800000.0

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.051

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.9

Epitope: Epitope of VHH H11-B5 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y449, N450, L452, L455, F456, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 57.0

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 8.1

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3900000.0

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.032

Epitope: Epitope of VHH H11-H6 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: G447, Y449, L452, L455, F456, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.55

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.3

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5500000.0

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.024

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 21.0

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.59

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH H11-H4 Q98R H100E D4 hybrid on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, Y449, N450, L452, L455, F456, T470, G482, V483, E484, Y489, F490, L492, Q493, S494
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 18.0