Reference: Jurgen van Heemst; Diahann T S L Jansen; Savvas Polydorides; Antonis K Moustakas; Marieke Bax; Anouk L Feitsma; Diënne G Bontrop-Elferink; Martine Baarse; Diane van der Woude; Gert-Jan Wolbink; Theo Rispens; Frits Koning; René R P de Vries; George K Papadopoulos; Georgios Archontis; Tom W Huizinga; René E Toes. "Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis." Nature communications (2015).

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 39000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: VCL 622-636 VCL-DERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAANFENH
Position: 622-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 300000.0

Epitope: measles virus DERAA epitope
Chemical type: Peptide from protein
Sequence: SSRASDERAAHLPTS
Position: 456-470
Source molecule (GenBank): BAA33867.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: measles virus DERAA epitope
Chemical type: Peptide from protein
Sequence: SSRASDERAAHLPTS
Position: 456-470
Source molecule (GenBank): BAA33867.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: measles virus DERAA epitope
Chemical type: Peptide from protein
Sequence: SSRASDERAAHLPTS
Position: 456-470
Source molecule (GenBank): BAA33867.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: influenza A virus DERAA epitope
Chemical type: Peptide from protein
Sequence: VFEFSDERAANPIVP
Position: 463-477
Source molecule (GenBank): AHZ13527.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: influenza A virus DERAA epitope
Chemical type: Peptide from protein
Sequence: VFEFSDERAANPIVP
Position: 463-477
Source molecule (GenBank): AHZ13527.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: influenza A virus DERAA epitope
Chemical type: Peptide from protein
Sequence: VFEFSDERAANPIVP
Position: 463-477
Source molecule (GenBank): AHZ13527.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: human herpesvirus 7 DERAA epitope
Chemical type: Peptide from protein
Sequence: LAARADERAAFPDVG
Position: 364-378
Source molecule (GenBank): YP_073747.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: human herpesvirus 7 DERAA epitope
Chemical type: Peptide from protein
Sequence: LAARADERAAFPDVG
Position: 364-378
Source molecule (GenBank): YP_073747.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: human herpesvirus 7 DERAA epitope
Chemical type: Peptide from protein
Sequence: LAARADERAAFPDVG
Position: 364-378
Source molecule (GenBank): YP_073747.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: Bordetella pertussis DERAA epitope
Chemical type: Peptide from protein
Sequence: SPNLTDERAAQAGVT
Position: 165-179
Source molecule (GenBank): CPP72976.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Bordetella pertussis DERAA epitope
Chemical type: Peptide from protein
Sequence: SPNLTDERAAQAGVT
Position: 165-179
Source molecule (GenBank): CPP72976.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: Bordetella pertussis DERAA epitope
Chemical type: Peptide from protein
Sequence: SPNLTDERAAQAGVT
Position: 165-179
Source molecule (GenBank): CPP72976.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: Staphylococcus aureus DERAA epitope
Chemical type: Peptide from protein
Sequence: QDMNDDERAALTMAM
Position: 48-62
Source molecule (GenBank): CPP06859.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Staphylococcus aureus DERAA epitope
Chemical type: Peptide from protein
Sequence: QDMNDDERAALTMAM
Position: 48-62
Source molecule (GenBank): CPP06859.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: Staphylococcus aureus DERAA epitope
Chemical type: Peptide from protein
Sequence: QDMNDDERAALTMAM
Position: 48-62
Source molecule (GenBank): CPP06859.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: Haemophilus influenzae DERAA epitope
Chemical type: Peptide from protein
Sequence: RFHGDDERAAKVYEN
Position: 192-206
Source molecule (GenBank): WP_042601503.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Haemophilus influenzae DERAA epitope
Chemical type: Peptide from protein
Sequence: RFHGDDERAAKVYEN
Position: 192-206
Source molecule (GenBank): WP_042601503.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: Haemophilus influenzae DERAA epitope
Chemical type: Peptide from protein
Sequence: RFHGDDERAAKVYEN
Position: 192-206
Source molecule (GenBank): WP_042601503.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: Salmonella enteritidis DERAA epitope
Chemical type: Peptide from protein
Sequence: PLMMDDERAAKVYEN
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Salmonella enteritidis DERAA epitope
Chemical type: Peptide from protein
Sequence: PLMMDDERAAKVYEN
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Salmonella enteritidis DERAA epitope
Chemical type: Peptide from protein
Sequence: PLMMDDERAAKVYEN
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: Salmonella enteritidis DERAA epitope
Chemical type: Peptide from protein
Sequence: PLMMDDERAAKVYEN
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: Propionibacterium acnes DERAA epitope
Chemical type: Peptide from protein
Sequence: EEVFTDERAARLSHV
Position: 684-698
Source molecule (GenBank): WP_014167297.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Propionibacterium acnes DERAA epitope
Chemical type: Peptide from protein
Sequence: EEVFTDERAARLSHV
Position: 684-698
Source molecule (GenBank): WP_014167297.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 11000.0

Epitope: Propionibacterium acnes DERAA epitope
Chemical type: Peptide from protein
Sequence: EEVFTDERAARLSHV
Position: 684-698
Source molecule (GenBank): WP_014167297.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14000.0

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: VCL-DERAA epitope
Chemical type: Peptide from protein
Sequence: VFDERAANFE
Position: 625-634
Source molecule (GenBank): P18206.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: REEVFDERAANFEN
Chemical type: Peptide from protein
Sequence: REEVFDERAANFEN
Position: 622-635
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAANFEN
Chemical type: Peptide from protein
Sequence: REEVFDERAANFEN
Position: 622-635
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAANFE
Chemical type: Peptide from protein
Sequence: REEVFDERAANFE
Position: 622-634
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAANFE
Chemical type: Peptide from protein
Sequence: REEVFDERAANFE
Position: 622-634
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAANF
Chemical type: Peptide from protein
Sequence: REEVFDERAANF
Position: 622-633
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAANF
Chemical type: Peptide from protein
Sequence: REEVFDERAANF
Position: 622-633
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERAAN
Chemical type: Peptide from protein
Sequence: REEVFDERAAN
Position: 622-632
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDERAAN
Chemical type: Peptide from protein
Sequence: REEVFDERAAN
Position: 622-632
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAA
Position: 622-631
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDERAA
Chemical type: Peptide from protein
Sequence: REEVFDERAA
Position: 622-631
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDERAANRENH
Chemical type: Peptide, no natural source
Sequence: REEVFDERAANRENH
Assay category: MhcBinding
Result: Negative

Epitope: EEVFDERAANFENH
Chemical type: Peptide from protein
Sequence: EEVFDERAANFENH
Position: 623-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: EEVFDERAANFENH
Chemical type: Peptide from protein
Sequence: EEVFDERAANFENH
Position: 623-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: EVFDERAANFENH
Chemical type: Peptide from protein
Sequence: EVFDERAANFENH
Position: 624-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: EVFDERAANFENH
Chemical type: Peptide from protein
Sequence: EVFDERAANFENH
Position: 624-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: VFDERAANFENH
Chemical type: Peptide from protein
Sequence: VFDERAANFENH
Position: 625-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: VFDERAANFENH
Chemical type: Peptide from protein
Sequence: VFDERAANFENH
Position: 625-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive

Epitope: FDERAANFENH
Chemical type: Peptide from protein
Sequence: FDERAANFENH
Position: 626-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: FDERAANFENH
Chemical type: Peptide from protein
Sequence: FDERAANFENH
Position: 626-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: DERAANFENH
Chemical type: Peptide from protein
Sequence: DERAANFENH
Position: 627-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: DERAANFENH
Chemical type: Peptide from protein
Sequence: DERAANFENH
Position: 627-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: ERAANFENH
Chemical type: Peptide from protein
Sequence: ERAANFENH
Position: 628-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: ERAANFENH
Chemical type: Peptide from protein
Sequence: ERAANFENH
Position: 628-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: RAANFENH
Chemical type: Peptide from protein
Sequence: RAANFENH
Position: 629-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: RAANFENH
Chemical type: Peptide from protein
Sequence: RAANFENH
Position: 629-636
Source molecule (GenBank): P18206.4
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDRRAANFENH
Chemical type: Peptide, no natural source
Sequence: REEVFDRRAANFENH
Assay category: MhcBinding
Result: Positive-Low

Epitope: REEVFDARAANFENH
Chemical type: Peptide, no natural source
Sequence: REEVFDARAANFENH
Assay category: MhcBinding
Result: Positive

Epitope: REEVFDERRANFENH
Chemical type: Peptide, no natural source
Sequence: REEVFDERRANFENH
Assay category: MhcBinding
Result: Negative

Epitope: REEVFDERARNFENH
Chemical type: Peptide, no natural source
Sequence: REEVFDERARNFENH
Assay category: MhcBinding
Result: Positive-Low

Epitope: Lactobacillus sakei DERAA epitope
Chemical type: Peptide from protein
Sequence: FYPIDERAADFET
Position: 204-216
Source molecule (GenBank): WP_025016388.1
Assay category: MhcBinding
Result: Positive

Epitope: Lactobacillus sakei DERAA epitope
Chemical type: Peptide from protein
Sequence: FYPIDERAADFET
Position: 204-216
Source molecule (GenBank): WP_025016388.1
Assay category: MhcBinding
Result: Positive

Epitope: Lactobacillus curvatus DERAA epitope
Chemical type: Peptide from protein
Sequence: FYPLDERAADFET
Position: 204-216
Source molecule (GenBank): WP_039099487.1
Assay category: MhcBinding
Result: Positive

Epitope: Lactobacillus curvatus DERAA epitope
Chemical type: Peptide from protein
Sequence: FYPLDERAADFET
Position: 204-216
Source molecule (GenBank): WP_039099487.1
Assay category: MhcBinding
Result: Positive

Epitope: Campylobacter coli DERAA epitope
Chemical type: Peptide from protein
Sequence: LEFDDERAGNFEP
Position: 272-284
Source molecule (GenBank): WP_002779736.1
Assay category: MhcBinding
Result: Positive

Epitope: Campylobacter coli DERAA epitope
Chemical type: Peptide from protein
Sequence: LEFDDERAGNFEP
Position: 272-284
Source molecule (GenBank): WP_002779736.1
Assay category: MhcBinding
Result: Positive