Reference: P Fytili; G N Dalekos; V Schlaphoff; P V Suneetha; C Sarrazin; W Zauner; K Zachou; T Berg; M P Manns; C S Klade; M Cornberg; H Wedemeyer. "Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073." Vaccine (2008).

Epitope: Genotype 1 peptide 1
Chemical type: Peptide from protein
Sequence: CVNGVCWTV
Position: 1073-1081
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Genotype 1 peptide 1
Chemical type: Peptide from protein
Sequence: CVNGVCWTV
Position: 1073-1081
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Genotype 1 peptide 1
Chemical type: Peptide from protein
Sequence: CVNGVCWTV
Position: 1073-1081
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Genotype 1 peptide 1
Chemical type: Peptide from protein
Sequence: CVNGVCWTV
Position: 1073-1081
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Genotype 1 peptide 1
Chemical type: Peptide from protein
Sequence: CVNGVCWTV
Position: 1073-1081
Source molecule (GenBank): AAA86907.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 9.0

Epitope: Genotype 1 peptide 2
Chemical type: Peptide from protein
Sequence: CTNGVCWTV
Position: 1073-1081
Source molecule (GenBank): BAA09072.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 2
Chemical type: Peptide from protein
Sequence: CTNGVCWTV
Position: 1073-1081
Source molecule (GenBank): BAA09072.1
Assay category: MhcBinding
Result: Negative

Epitope: Genotype 1 peptide 3
Chemical type: Peptide from protein
Sequence: CVSGACWTV
Position: 1073-1081
Source molecule (GenBank): AAL91977.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 3
Chemical type: Peptide from protein
Sequence: CVSGACWTV
Position: 1073-1081
Source molecule (GenBank): AAL91977.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 4.0

Epitope: Genotype 1 peptide 4
Chemical type: Peptide from protein
Sequence: CISGVCWTV
Position: 1073-1081
Source molecule (GenBank): ACE82433.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 4
Chemical type: Peptide from protein
Sequence: CISGVCWTV
Position: 1073-1081
Source molecule (GenBank): ACE82433.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 35.0

Epitope: Genotype 1 peptide 5
Chemical type: Peptide from protein
Sequence: CINGACWTV
Position: 1073-1081
Source molecule (GenBank): BAB18810.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 5
Chemical type: Peptide from protein
Sequence: CINGACWTV
Position: 1073-1081
Source molecule (GenBank): BAB18810.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 11.0

Epitope: Genotype 1 peptide 6
Chemical type: Peptide from protein
Sequence: CVNGACWTV
Position: 1073-1081
Source molecule (GenBank): Q913V3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 6
Chemical type: Peptide from protein
Sequence: CVNGACWTV
Position: 1073-1081
Source molecule (GenBank): Q913V3.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1.0

Epitope: Genotype 1 peptide 7
Chemical type: Peptide from protein
Sequence: CINGVCWSV
Position: 1073-1081
Source molecule (GenBank): BAG31965.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 7
Chemical type: Peptide from protein
Sequence: CINGVCWSV
Position: 1073-1081
Source molecule (GenBank): BAG31965.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 40.0

Epitope: Genotype 1 peptide 8
Chemical type: Peptide from protein
Sequence: CINGVCWSI
Position: 47-55
Source molecule (GenBank): BAC67110.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 1 peptide 8
Chemical type: Peptide from protein
Sequence: CINGVCWSI
Position: 47-55
Source molecule (GenBank): BAC67110.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 19.0

Epitope: Genotype 2 peptide 9
Chemical type: Peptide from protein
Sequence: CISGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAP55699.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 2 peptide 9
Chemical type: Peptide from protein
Sequence: CISGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAP55699.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 17.0

Epitope: Genotype 2 peptide 10
Chemical type: Peptide from protein
Sequence: TISGVLWTV
Position: 1077-1085
Source molecule (GenBank): P26660.3
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 2 peptide 10
Chemical type: Peptide from protein
Sequence: TISGVLWTV
Position: 1077-1085
Source molecule (GenBank): P26660.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 129.0

Epitope: Genotype 2 peptide 11
Chemical type: Peptide from protein
Sequence: SISGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAP55704.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 2 peptide 11
Chemical type: Peptide from protein
Sequence: SISGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAP55704.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 104.0

Epitope: Genotype 2 peptide 12
Chemical type: Peptide from protein
Sequence: SIAGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAF59940.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 2 peptide 12
Chemical type: Peptide from protein
Sequence: SIAGVLWTV
Position: 1077-1085
Source molecule (GenBank): AAF59940.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 160.0

Epitope: Genotype 2 peptide 13
Chemical type: Peptide from protein
Sequence: TISGILWTV
Position: 1077-1085
Source molecule (GenBank): Q9IZA3.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 2 peptide 13
Chemical type: Peptide from protein
Sequence: TISGILWTV
Position: 1077-1085
Source molecule (GenBank): Q9IZA3.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 172.0

Epitope: Genotype 3 peptide 15
Chemical type: Peptide from protein
Sequence: SVGGVMWTV
Position: 1078-1086
Source molecule (GenBank): Q68801.3
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 3 peptide 15
Chemical type: Peptide from protein
Sequence: SVGGVMWTV
Position: 1078-1086
Source molecule (GenBank): Q68801.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 134.0

Epitope: Genotype 3 peptide 17
Chemical type: Peptide from protein
Sequence: AIGGVMWTV
Position: 47-55
Source molecule (GenBank): ACH97650.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 3 peptide 17
Chemical type: Peptide from protein
Sequence: AIGGVMWTV
Position: 47-55
Source molecule (GenBank): ACH97650.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 66.0

Epitope: Genotype 3 peptide 18
Chemical type: Peptide from protein
Sequence: TVGDVMWTV
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 3 peptide 18
Chemical type: Peptide from protein
Sequence: TVGDVMWTV
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 165.0

Epitope: Genotype 3 peptide 19
Chemical type: Peptide from protein
Sequence: TVGGVMWTV
Position: 1079-1087
Source molecule (GenBank): Q68870.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 3 peptide 19
Chemical type: Peptide from protein
Sequence: TVGGVMWTV
Position: 1079-1087
Source molecule (GenBank): Q68870.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 133.0

Epitope: Genotype 4 peptide 21
Chemical type: Peptide from protein
Sequence: AVNGVMWTV
Position: 1073-1081
Source molecule (GenBank): ABL63009.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 4 peptide 21
Chemical type: Peptide from protein
Sequence: AVNGVMWTV
Position: 1073-1081
Source molecule (GenBank): ABL63009.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 134.0

Epitope: Genotype 5 peptide 22
Chemical type: Peptide from protein
Sequence: CINGVMWTL
Position: 1074-1082
Source molecule (GenBank): O39928.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 5 peptide 22
Chemical type: Peptide from protein
Sequence: CINGVMWTL
Position: 1074-1082
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 63.0

Epitope: Genotype 6 peptide 23
Chemical type: Peptide from protein
Sequence: SINGVMWTV
Position: 1077-1085
Source molecule (GenBank): O39927.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 6 peptide 23
Chemical type: Peptide from protein
Sequence: SINGVMWTV
Position: 1077-1085
Source molecule (GenBank): O39927.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 143.0

Epitope: Genotype 6 peptide 26
Chemical type: Peptide from protein
Sequence: AVNGVLWTV
Position: 1074-1082
Source molecule (GenBank): O92532.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 6 peptide 26
Chemical type: Peptide from protein
Sequence: AVNGVLWTV
Position: 1074-1082
Source molecule (GenBank): O92532.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 114.0

Epitope: Genotype 6 peptide 27
Chemical type: Peptide from protein
Sequence: TINGVLWTV
Position: 1078-1086
Source molecule (GenBank): O92529.3
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 6 peptide 27
Chemical type: Peptide from protein
Sequence: TINGVLWTV
Position: 1078-1086
Source molecule (GenBank): O92529.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 133.0

Epitope: Genotype 6 peptide 28
Chemical type: Peptide from protein
Sequence: TVNGVLWTV
Position: 1075-1083
Source molecule (GenBank): BAA32666.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Genotype 6 peptide 28
Chemical type: Peptide from protein
Sequence: TVNGVLWTV
Position: 1075-1083
Source molecule (GenBank): BAA32666.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 117.0

Epitope: Genotype 1 peptide 1 variant
Chemical type: Peptide from protein
Sequence: CINGVCWTV
Position: 1073-1081
Source molecule (GenBank): BAB18806.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Genotype 1 peptide 1 variant
Chemical type: Peptide from protein
Sequence: CINGVCWTV
Position: 1073-1081
Source molecule (GenBank): BAB18806.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone