Reference: Tiing Jen Loh; Jia Jia Lim; Claerwen M Jones; Hien Thy Dao; Mai T Tran; Daniel G Baker; Nicole L La Gruta; Hugh H Reid; Jamie Rossjohn. "The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4." Nature communications (2024).

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Quantitative measurement: 2.65
Host:  13-20 weeks

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Quantitative measurement: 2.75
Host:  13-20 weeks

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 104100.0

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive-Intermediate
Quantitative measurement: 31900.0
Host:  13-20 weeks

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Quantitative measurement: 6200.0
Host:  13-20 weeks

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.6

Epitope: Vim-64cit 59-71
Chemical type: Peptide from protein
Sequence: GVYATRSSAVRLR
Position: 59-71
Source molecule (GenBank): P08670.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.75

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Host:  13-20 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Quantitative measurement: 7100.0

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: α-eno-15cit 10-22
Chemical type: Peptide from protein
Sequence: EIFDSRGNPTVEV
Position: 10-22
Source molecule (GenBank): P06733.2
Assay category: TCell
Result: Positive
Quantitative measurement: 7100.0

Epitope: Fibß-74Cit 69-81
Chemical type: Peptide from protein
Sequence: GGYRARPAKAAAT
Position: 69-81
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Positive
Quantitative measurement: 7600.0
Host:  10-18 weeks

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: TCell
Result: Positive
Quantitative measurement: 7100.0

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: TCell
Result: Positive
Quantitative measurement: 2.4

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: TCell
Result: Positive
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: TCell
Result: Positive
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: α-eno-15cit 10-22V20G
Chemical type: Peptide, no natural source
Sequence: EIFDSRGNPTGEV
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.4