Reference: Caroline S Colley; Bojana Popovic; Sudharsan Sridharan; Judit E Debreczeni; David Hargeaves; Michael Fung; Ling-Ling An; Bryan Edwards; Joanne Arnold; Elizabeth England; Laura Eghobamien; Ulf Sivars; Liz Flavell; Jonathan Renshaw; Kate Wickson; Paul Warrener; Jingying Zha; Jessica Bonnell; Rob Woods; Trevor Wilkinson; Claire Dobson; Tristan J Vaughan. "Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors." mAbs (2018).

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0040

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.027

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000251

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.019

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 8080000.0

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000154

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.014

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 2.12

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive
Quantitative measurement: 17400000

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Negative

Epitope: Epitope of MEDI7814 on complement C5
Chemical type: Discontinuous protein residues
Discontinuous residues: K691, H692, S693, V694, V695, K697, C698, D701, C704, E709, R714, R717, I718, S719, L720, G721, P722, R723, C724, F728
Source molecule (GenBank): P01031.4
Assay category: BCell
Result: Positive