Reference: Maki Nakayama; Kristen McDaniel; Lisa Fitzgerald-Miller; Carol Kiekhaefer; Janet K Snell-Bergeon; Howard W Davidson; Marian Rewers; Liping Yu; Peter Gottlieb; John W Kappler; Aaron Michels. "Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects." Proceedings of the National Academy of Sciences of the United States of America (2015).

Epitope: B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  10-21 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  10-27 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive-Low
Host:  23-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  23-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  10-21 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  10-27 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGEEG
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B21G,22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGGEG
Assay category: TCell
Result: Positive
Host:  10-21 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B21G,22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGGEG
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B21G,22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGGEG
Assay category: TCell
Result: Positive
Host:  14-53 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B:9-33(B21G,22E)
Chemical type: Peptide, no natural source
Sequence: SHLVEALYLVCGGEG
Assay category: TCell
Result: Positive
Host:  10-27 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo