Reference: Salman Shahid; Sharanbasappa S Karade; S Saif Hasan; Rui Yin; Liqun Jiang; Yanxin Liu; Nathaniel Felbinger; Liudmila Kulakova; Eric A Toth; Zhen-Yong Keck; Steven K H Foung; Thomas R Fuerst; Brian G Pierce; Roy A Mariuzza. "Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers." Communications biology (2025).

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.14

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.07

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.15

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab HC84.26-on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H243, I244, L249, L260, L263, F264, Y265, T266, K268, G326, P327, Y329, P434, Y435, L437, W438, V444
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab CBH7 on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: W242, H243, R246, Y329, T332, S334, P335, V336, V337, V338, G339, G345, P366, Q368, G369, N370, W371, V455, G457, V458, E459, H460, R461, L462, N463
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 19.0

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 19.0

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.07

Epitope: Epitope of Fab CBH4B on HCV E2
Chemical type: Discontinuous protein residues
Discontinuous residues: D406, F408, R409, P412, A414, T426, R428, C429, F449, K450, V451, R452, Y454, E459
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.08