Reference: Kriti Khatri; Alyssa Ball; Jill Glesner; Christina Linn; Lisa D Vailes; Sabina Wünschmann; Scott A Gabel; Jian Zhang; R Stokes Peebles; Tomasz Borowski; Geoffrey A Mueller; Martin D Chapman; Scott A Smith; Anna Pomés; Maksymilian Chruszcz. "Human IgE monoclonal antibodies define two unusual epitopes trapping dog allergen Can f 1 in different conformations." Protein science : a publication of the Protein Society (2025).

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000222

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2020000.0

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.11

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.59

Epitope: Epitope of human IgE mAb 1J11 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, S32, G33, K34, I57, L58, K59, A60, K62, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.15

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.58

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 179000.0

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000602

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.85

Epitope: Epitope of human IgE mAb 12F3 Fab on Can f 1
Chemical type: Discontinuous protein residues
Discontinuous residues: V29, V31, S32, W35, L58, K59, A60, Q61, G64, N65, L66, E90, P91, G92, Y94, I105, Q106, P107, S108, P109, V110, R111, D112, H113, Y114, L133, R135
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.12

Epitope: Can F 1 mutant AKAA
Chemical type: Discontinuous protein residues
Discontinuous residues: S32, G33, D112, Y114
Source molecule (GenBank): O18873.1
Assay category: BCell
Result: Positive