Reference: Kenneth J Katschke; Ping Wu; Rajkumar Ganesan; Robert F Kelley; Mary A Mathieu; Philip E Hass; Jeremy Murray; Daniel Kirchhofer; Christian Wiesmann; Menno van Lookeren Campagne. "Inhibiting alternative pathway complement activation by targeting the factor D exosite." The Journal of biological chemistry (2012).

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 0.03
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0085
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0040
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 2.42
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 82000000
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00033
Host: M

Epitope: Epitope of AFD Fab on human Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, P144, D175, R176, A177, T178, N180, R181, R182, T183, D186, G187, E191, R232, K233
Source molecule (GenBank): P00746.5
Assay category: BCell
Result: Positive
Quantitative measurement: 280000000
Host: M

Epitope: Epitope of AFD Fab on cynomolgus Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D116, P119, D150, R151, A152, T153, N155, R156, R157, T158, D161, G162, I164, Q166, K208
Source molecule (GenBank): 4D9Q_A
Assay category: BCell
Result: Positive
Quantitative measurement: 0.03
Host: M

Epitope: Epitope of AFD Fab on cynomolgus Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D116, P119, D150, R151, A152, T153, N155, R156, R157, T158, D161, G162, I164, Q166, K208
Source molecule (GenBank): 4D9Q_A
Assay category: BCell
Result: Positive
Quantitative measurement: 280000000
Host: M

Epitope: Epitope of AFD Fab on cynomolgus Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D116, P119, D150, R151, A152, T153, N155, R156, R157, T158, D161, G162, I164, Q166, K208
Source molecule (GenBank): 4D9Q_A
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0085
Host: M

Epitope: Epitope of AFD Fab on cynomolgus Factor D
Chemical type: Discontinuous protein residues
Discontinuous residues: D116, P119, D150, R151, A152, T153, N155, R156, R157, T158, D161, G162, I164, Q166, K208
Source molecule (GenBank): 4D9Q_A
Assay category: BCell
Result: Positive
Quantitative measurement: 2.28
Host: M