Reference: Robert J Ragotte; David Pulido; Amelia M Lias; Doris Quinkert; Daniel G W Alanine; Abhishek Jamwal; Hannah Davies; Adéla Nacer; Edward D Lowe; Geoffrey W Grime; Joseph J Illingworth; Robert F Donat; Elspeth F Garman; Paul W Bowyer; Matthew K Higgins; Simon J Draper. "Heterotypic interactions drive antibody synergy against a malaria vaccine candidate." Nature communications (2022).

Epitope: Epitope of Fab Cy.002 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F124, S125, L160, P184, Y185, F187, K188, D189, Y219, K220, L221, G222, V223, G244, D245, N246, I247, N248, V250, N252
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.94
Host: F 6-8 weeks

Epitope: Epitope of Fab Cy.002 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F124, S125, L160, P184, Y185, F187, K188, D189, Y219, K220, L221, G222, V223, G244, D245, N246, I247, N248, V250, N252
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00029
Host: F 6-8 weeks

Epitope: Epitope of Fab Cy.002 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F124, S125, L160, P184, Y185, F187, K188, D189, Y219, K220, L221, G222, V223, G244, D245, N246, I247, N248, V250, N252
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 310000.0
Host: F 6-8 weeks

Epitope: Epitope of Fab Cy.002 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F124, S125, L160, P184, Y185, F187, K188, D189, Y219, K220, L221, G222, V223, G244, D245, N246, I247, N248, V250, N252
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.72
Host: F 6-8 weeks

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 120000.0

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 38.0

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0047

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.14

Epitope: Epitope of Fab Cy.003 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: R135, Y137, N139, E143, N145, N146, R174, H202, D203, K204, E206, T207
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.27

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 2800.0

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 0.44

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 160000.0

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.27

Epitope: Epitope of Fab Cy.004 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: F94, K95, E96, T97, D98, L99, T100, E120, E122, E123, N126, K128, T132, H134, E148
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.79

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.011

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 100000.0

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 110.0

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.09

Epitope: Epitope of Fab Cy.007 on Pf CyRPA
Chemical type: Discontinuous protein residues
Discontinuous residues: K43, N45, Y61, E74, Y78, K81, V83, K84, S86, W87, I88, T89, L90, K95, D140, G141, K142
Source molecule (GenBank): Q8IFM8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.27

Epitope: Epitope of Fab R5.016 on Pf RH5
Chemical type: Discontinuous protein residues
Discontinuous residues: I193, T199, G201, K202, Y203, I204, A205, D207, A208, F209, K211, K212, I213, E215, Y335, L339
Source molecule (GenBank): ACB87908.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.53