Reference: Tim Postmus; Robin Jansen; Paul Kaijen; Floris van Alphen; Carmen van der Zwaan; Arie J Hoogendijk; Paul Coppo; Bérangère S Joly; Agnès Veyradier; Karen Vanhoorelbeke; Gerry Nicolaes; Jan Voorberg. "Trp1250, Lys1252, and Arg1367 of ADAMTS13 comprise a hot spot for anti-CUB domain antibodies in patients with iTTP." Blood advances (2025).

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00012

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.56

Epitope: Epitope residues of mAb 1-403 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1245, W1250
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 76700.0

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 13.4

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 166000.0

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00221

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 8.22

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 236000.0

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00194

Epitope: Epitope residues of mAb 1-407 and 1-410 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: K1252, R1255
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.92

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 644000.0

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00188

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.24

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 517000.0

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00167

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-440 and z1-201 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1251, K1252, R1361, S1365, L1366
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.264

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 298000.0

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000789

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb 1-441 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: R1367, E1382
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0418

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1140000.0

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000474

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive

Epitope: Epitope residues of mAb z1-303 on ADAMTS13
Chemical type: Discontinuous protein residues
Discontinuous residues: W1250, R1251
Source molecule (GenBank): Q76LX8.1
Assay category: BCell
Result: Positive