Reference: Patricia T Vietheer; Irene Boo; Jun Gu; Kathleen McCaffrey; Stirling Edwards; Catherine Owczarek; Matthew P Hardy; Louis Fabri; Rob J Center; Pantelis Poumbourios; Heidi E Drummer. "The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs." Hepatology (Baltimore, Md.) (2017).

Epitope: H77c E2 (408-428)
Chemical type: Peptide from protein
Sequence: KQNIQLINTNGSWHINSTALN
Position: 408-428
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: H77c E2 (430-451)
Chemical type: Peptide from protein
Sequence: NESLNTGWLAGLFYQHKFNSSG
Position: 430-451
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: H77c E2 (523-549)
Chemical type: Peptide from protein
Sequence: GAPTYSWGANDTDVFVLNNTRPPLGNW
Position: 523-549
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: J6 E2 (408-428)
Chemical type: Peptide from protein
Sequence: RQKIQLVNTNGSWHINRTALN
Position: 408-428
Source molecule (GenBank): AEJ90142.1
Assay category: BCell
Result: Positive

Epitope: J6 E2 (430-451)
Chemical type: Peptide from protein
Sequence: NDSLHTGFIASLFYTHSFNSSG
Position: 430-451
Source molecule (GenBank): AEJ90142.1
Assay category: BCell
Result: Negative

Epitope: J6 E2 (523-549)
Chemical type: Peptide from protein
Sequence: GAPTYTWGENETDVFLLNSTRPPLGSW
Position: 525-551
Source molecule (GenBank): AEJ90142.1
Assay category: BCell
Result: Positive

Epitope: HC84-27
Chemical type: Discontinuous protein residues
Discontinuous residues: A439, L441, F442, Y443, Q444, K446, W616
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: HC84-27
Chemical type: Discontinuous protein residues
Discontinuous residues: A439, L441, F442, Y443, Q444, K446, W616
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: AR3C
Chemical type: Discontinuous protein residues
Discontinuous residues: I422, T425, L427, C429, N430, E431, S432, L433, G436, L438, A439, L441, F442, Y443, K446, W529
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive
Host: F 35 years

Epitope: AR3C
Chemical type: Discontinuous protein residues
Discontinuous residues: I422, T425, L427, C429, N430, E431, S432, L433, G436, L438, A439, L441, F442, Y443, K446, W529
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: CBH-4B
Chemical type: Peptide from protein
Sequence: RMYVGG
Position: 630-635
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: CBH-4B
Chemical type: Peptide from protein
Sequence: RMYVGG
Position: 630-635
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: HC84.26
Chemical type: Discontinuous protein residues
Discontinuous residues: C429, L441, F442, K446, W616
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: HC-11
Chemical type: Discontinuous protein residues
Discontinuous residues: S424, T425, A426, L427, N428, C429, T435, G436, W437, L438, F442, Y443, K446, Y527, W529, G530, D535, V536
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: HC84-22
Chemical type: Discontinuous protein residues
Discontinuous residues: W420, I422, A426, L427, N428, C429, W437, L441, F442, Y443, G530, D535, W616
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: HC-1
Chemical type: Discontinuous protein residues
Discontinuous residues: A426, N428, C429, W529, G530, D535
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: CBH-4D
Chemical type: Discontinuous protein residues
Discontinuous residues: V536, R630, M631, Y632, V633, G634, G635, P612, L615
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Negative

Epitope: CBH-7
Chemical type: Discontinuous protein residues
Discontinuous residues: N540, W549
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: AR1A
Chemical type: Discontinuous protein residues
Discontinuous residues: T416, N417, P484, Y485, V538, N540, G547, W549
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive
Host: F 35 years

Epitope: AR1B
Chemical type: Discontinuous protein residues
Discontinuous residues: Q412, W420, N423, R483, P484, Y485, G523, P525, T526, G530, T534, N540, P544, P545, G547, W549
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive
Host: F 35 years

Epitope: AR3D
Chemical type: Discontinuous protein residues
Discontinuous residues: Q412, S424, G523, G530, D535
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive
Host: F 35 years

Epitope: HCV1
Chemical type: Discontinuous protein residues
Discontinuous residues: L413, N415, G418, W420, I422
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: HCV1
Chemical type: Discontinuous protein residues
Discontinuous residues: L413, N415, G418, W420, I422
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: H53
Chemical type: Discontinuous protein residues
Discontinuous residues: N540, W549
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: H52
Chemical type: Discontinuous protein residues
Discontinuous residues: C652
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: MAb24
Chemical type: Discontinuous protein residues
Discontinuous residues: L413, I414, N415, T416, G418, W420, H421
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: MAb44
Chemical type: Discontinuous protein residues
Discontinuous residues: G523, P525, N540, W549, Y613
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: MAb26
Chemical type: Peptide from protein
Sequence: NWTRGER
Position: 645-651
Source molecule (GenBank): AAB67036.1
Assay category: BCell
Result: Positive

Epitope: MAbs 6 and 25
Chemical type: Discontinuous protein residues
Discontinuous residues: Y527, W529, G530, D535
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: MAb14
Chemical type: Discontinuous protein residues
Discontinuous residues: P525, Y527, W529, G530
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive

Epitope: MAb39
Chemical type: Discontinuous protein residues
Discontinuous residues: G523, P525
Source molecule (GenBank): AAB67037.1
Assay category: BCell
Result: Positive