Reference: Palak N Patel; Ababacar Diouf; Thayne H Dickey; Wai Kwan Tang; Christine S Hopp; Boubacar Traore; Carole A Long; Kazutoyo Miura; Peter D Crompton; Niraj H Tolia. "A strain-transcending anti-AMA1 human monoclonal antibody neutralizes malaria parasites independent of direct RON2L receptor blockade." Cell reports. Medicine (2025).

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Negative
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 237700.0
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.9
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 205700.0
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0003213
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0002057
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 303700.0
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.001
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.23
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0002917
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.057
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75B10 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: T194, L195, D196, R199, K209, D242, K243, D244, K245, K246, Q285, N286, K305, Q308, H433, I435, E436, V437, E438
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.01551
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 255000.0
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0240233
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 353300.0
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 54.06
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 43.967
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 94.61
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.01854
Host: F 37 years

Epitope: Epitope of 75C8 Fab on AMA1
Chemical type: Discontinuous protein residues
Discontinuous residues: I157, I158, E159, S161, N162, R277, D281, I282, S283, P330, A331, I332, E336, K339, L340, T406, Q407
Source molecule (GenBank): Q7KQK5.1
Assay category: BCell
Result: Positive
Quantitative measurement: 351000.0
Host: F 37 years