Reference: Michael Volkmar; Dana Hoser; Claudia Lauenstein; Janina Rebmann; Agnes Hotz-Wagenblatt; Jan Rieger; Isabel Poschke; Jonas P Becker; Angelika B Riemer; Martin Sprick; Andreas Trumpp; Oliver Strobel; Thomas Blankenstein; Gerald Willimsky; Rienk Offringa. "Enhanced mutanome analysis towards the induction of neoepitope-reactive T-cell responses for personalized immunotherapy of pancreatic cancer." Journal for immunotherapy of cancer (2025).

Epitope: ALDH4A1_R247H
Chemical type: Peptide, no natural source
Sequence: MLASYAVYHI
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ALDH4A1_R247H
Chemical type: Peptide, no natural source
Sequence: MLASYAVYHI
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: ATAD2_R913C
Chemical type: Peptide, no natural source
Sequence: FICDYGEIFNV
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ATAD2_R913C
Chemical type: Peptide, no natural source
Sequence: FICDYGEIFNV
Assay category: MhcBinding
Result: Positive-High

Epitope: DNM3_R369H
Chemical type: Peptide, no natural source
Sequence: RIFHEHFPFEI
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DNM3_R369H
Chemical type: Peptide, no natural source
Sequence: RIFHEHFPFEI
Assay category: MhcBinding
Result: Positive-Low

Epitope: FAM160B1_V418I
Chemical type: Peptide, no natural source
Sequence: ALLHRIIRQV
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: FAM160B1_V418I
Chemical type: Peptide, no natural source
Sequence: ALLHRIIRQV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1_V785I
Chemical type: Peptide, no natural source
Sequence: FLFNDILLYT
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FILIP1L_F109V_a
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: FILIP1L_F109V_b
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGVV
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: FILIP1L_F109V_b
Chemical type: Peptide, no natural source
Sequence: ALLEAQYGVV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: KRAS_G12V
Chemical type: Peptide, no natural source
Sequence: KLVVVGAVGV
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS_G12V
Chemical type: Peptide, no natural source
Sequence: KLVVVGAVGV
Assay category: MhcBinding
Result: Positive-Low

Epitope: NOTCH2_P1947A
Chemical type: Peptide, no natural source
Sequence: RMNDGTTAL
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NOTCH2_P1947A
Chemical type: Peptide, no natural source
Sequence: RMNDGTTAL
Assay category: MhcBinding
Result: Positive-Low

Epitope: PAPSS1_A71T
Chemical type: Peptide, no natural source
Sequence: SMTLEEYLV
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PAPSS1_A71T
Chemical type: Peptide, no natural source
Sequence: SMTLEEYLV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6_K164E
Chemical type: Peptide, no natural source
Sequence: YILRELPEV
Assay category: MhcBinding
Result: Positive-High

Epitope: SLCO2A1_F338L_a
Chemical type: Peptide, no natural source
Sequence: TLSSVIAGL
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLCO2A1_F338L_a
Chemical type: Peptide, no natural source
Sequence: TLSSVIAGL
Assay category: MhcBinding
Result: Positive-High

Epitope: SLCO2A1_F338L_b
Chemical type: Peptide, no natural source
Sequence: VLAQCTLSSV
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLCO2A1_F338L_b
Chemical type: Peptide, no natural source
Sequence: VLAQCTLSSV
Assay category: MhcBinding
Result: Positive-High

Epitope: TP53_N131Y_a
Chemical type: Peptide, no natural source
Sequence: ALYKMFCQL
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TP53_N131Y_a
Chemical type: Peptide, no natural source
Sequence: ALYKMFCQL
Assay category: MhcBinding
Result: Positive-Low

Epitope: TP53_N131Y_b
Chemical type: Peptide, no natural source
Sequence: YKMFCQLAKT
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TP53_N131Y_b
Chemical type: Peptide, no natural source
Sequence: YKMFCQLAKT
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: TRAM1_L256V
Chemical type: Peptide, no natural source
Sequence: SLWAVVFVL
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TRAM1_L256V
Chemical type: Peptide, no natural source
Sequence: SLWAVVFVL
Assay category: MhcBinding
Result: Positive-High

Epitope: TRRAP_D859N
Chemical type: Peptide, no natural source
Sequence: NFLYDHIQPV
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TRRAP_D859N
Chemical type: Peptide, no natural source
Sequence: NFLYDHIQPV
Assay category: MhcBinding
Result: Positive-High

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A_S54R
Chemical type: Peptide, no natural source
Sequence: RMYHSLTYA
Assay category: MhcBinding
Result: Positive-Low

Epitope: ALDH4A1
Chemical type: Peptide from protein
Sequence: MLASYAVYRI
Position: 239-248
Source molecule (GenBank): P30038.3
Assay category: MhcBinding
Result: Positive

Epitope: ATAD2
Chemical type: Peptide from protein
Sequence: FIRDYGEIFNV
Position: 911-921
Source molecule (GenBank): Q6PL18.1
Assay category: MhcBinding
Result: Positive

Epitope: DNM3
Chemical type: Peptide from protein
Sequence: RIFHERFPFEI
Position: 364-374
Source molecule (GenBank): Q9UQ16.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: FAM160B1
Chemical type: Peptide from protein
Sequence: ALLHRIVRQV
Position: 412-421
Source molecule (GenBank): Q5W0V3.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: FARP1
Chemical type: Peptide from protein
Sequence: FLFNDVLLYT
Position: 780-789
Source molecule (GenBank): Q9Y4F1.1
Assay category: MhcBinding
Result: Positive

Epitope: FILIP1L_b
Chemical type: Peptide from protein
Sequence: ALLEAQYGFV
Position: 101-110
Source molecule (GenBank): Q4L180.2
Assay category: MhcBinding
Result: Positive

Epitope: KRAS
Chemical type: Peptide from protein
Sequence: KLVVVGAGGV
Position: 5-14
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Positive

Epitope: NOTCH2
Chemical type: Peptide from protein
Sequence: RMNDGTTPL
Position: 1940-1948
Source molecule (GenBank): Q04721.3
Assay category: MhcBinding
Result: Positive

Epitope: PAPSS1
Chemical type: Peptide from protein
Sequence: SMALEEYLV
Position: 69-77
Source molecule (GenBank): O43252.2
Assay category: MhcBinding
Result: Positive

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: RABL6
Chemical type: Peptide from protein
Sequence: YILRELPKV
Position: 157-165
Source molecule (GenBank): Q3YEC7.2
Assay category: MhcBinding
Result: Positive-High

Epitope: SLCO2A1_a
Chemical type: Peptide from protein
Sequence: TFSSVIAGL
Position: 337-345
Source molecule (GenBank): Q92959.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: SLCO2A1_b
Chemical type: Peptide from protein
Sequence: VLAQCTFSSV
Position: 332-341
Source molecule (GenBank): Q92959.2
Assay category: MhcBinding
Result: Positive-High

Epitope: TP53_a
Chemical type: Peptide from protein
Sequence: ALNKMFCQL
Position: 129-137
Source molecule (GenBank): P04637.4
Assay category: MhcBinding
Result: Positive-Low

Epitope: TP53_b
Chemical type: Peptide from protein
Sequence: NKMFCQLAKT
Position: 131-140
Source molecule (GenBank): P04637.4
Assay category: MhcBinding
Result: Positive

Epitope: TRAM1
Chemical type: Peptide from protein
Sequence: SLWAVLFVL
Position: 251-259
Source molecule (GenBank): Q15629.3
Assay category: MhcBinding
Result: Positive-High

Epitope: TRRAP
Chemical type: Peptide from protein
Sequence: DFLYDHIQPV
Position: 859-868
Source molecule (GenBank): Q9Y4A5.3
Assay category: MhcBinding
Result: Positive-High

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: pancreas
Culture conditions: Cell Line / Clone

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: TTC39A
Chemical type: Peptide from protein
Sequence: SMYHSLTYA
Position: 54-62
Source molecule (GenBank): Q5SRH9.1
Assay category: MhcBinding
Result: Positive