Reference: Lisa C Lindesmith; Paul D Brewer-Jensen; Michael L Mallory; Mark R Zweigart; Samantha R May; Daniel Kelly; Rachel Williams; Sylvia Becker-Dreps; Filemón Bucardo; David J Allen; Judith Breuer; Ralph S Baric. "Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure." Viruses (2022).

Epitope: 2012 Sydney Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-Low

Epitope: 2012 Sydney Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-Intermediate
Host:  <5 years

Epitope: 2012 Sydney Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, T340, D341, F375, E376, A377, N378
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-Low
Host:  <5 years

Epitope: 2012 Sydney Site A+G
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive

Epitope: 2012 Sydney Site A+G
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-High
Host:  <5 years

Epitope: 2012 Sydney Site A+C+G
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, R339, T340, D341, Y352, S355, A356, D357, A359, R364, E368, D372, H373, F375, E376, A377, N378
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive

Epitope: 2012 Sydney Site A+C+G
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, R339, T340, D341, Y352, S355, A356, D357, A359, R364, E368, D372, H373, F375, E376, A377, N378
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-High
Host:  <5 years

Epitope: 2012 Sydney Site A+C+G
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, R339, T340, D341, Y352, S355, A356, D357, A359, R364, E368, D372, H373, F375, E376, A377, N378
Source molecule (GenBank): AGJ52172.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb 2012.G5 on GII.4 VP1
Chemical type: Discontinuous protein residues
Discontinuous residues: E368
Source molecule (GenBank): AFV08795.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 2012.G8 on GII.4 VP1
Chemical type: Discontinuous protein residues
Discontinuous residues: R373
Source molecule (GenBank): AFV08795.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: 2012 Camberwell Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: V294, G295, S296, H297, D298, T368, N372, N373
Source molecule (GenBank): AAK50355.1
Assay category: BCell
Result: Positive
Host:  >/= 15 years

Epitope: 2012 Camberwell Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, S355, V356, H357, T359, S364
Source molecule (GenBank): AAK50355.1
Assay category: BCell
Result: Positive
Host:  >/= 15 years

Epitope: 2012 Camberwell Site A+G
Chemical type: Discontinuous protein residues
Discontinuous residues: V294, G295, S296, H297, D298, S352, S355, V356, H357, T359, S364, T368, N372, N373
Source molecule (GenBank): AAK50355.1
Assay category: BCell
Result: Positive
Host:  >/= 15 years

Epitope: 2012 Camberwell Site A+C+G
Chemical type: Discontinuous protein residues
Discontinuous residues: V294, G295, S296, H297, D298, R339, A340, D341, S352, S355, V356, H357, T359, S364, T368, N372, N373, F375, Q376, T377, G378
Source molecule (GenBank): AAK50355.1
Assay category: BCell
Result: Positive-High
Host:  >/= 15 years