Reference: Xiaomin Wen; Junbao Yang; Eddie James; I-Ting Chow; Helena Reijonen; William W Kwok. "Increased islet antigen-specific regulatory and effector CD4<sup>+</sup> T cells in healthy individuals with the type 1 diabetes-protective haplotype." Science immunology (2020).

Epitope: p18
Chemical type: Peptide from protein
Sequence: YPNELLQEYNWELADQPQNL
Position: 137-156
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p18
Chemical type: Peptide from protein
Sequence: YPNELLQEYNWELADQPQNL
Position: 137-156
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: p18
Chemical type: Peptide from protein
Sequence: YPNELLQEYNWELADQPQNL
Position: 137-156
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: p18
Chemical type: Peptide from protein
Sequence: YPNELLQEYNWELADQPQNL
Position: 137-156
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: p18
Chemical type: Peptide from protein
Sequence: YPNELLQEYNWELADQPQNL
Position: 137-156
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: p41
Chemical type: Peptide from protein
Sequence: EAKQKGFVPFLVSATAGTTV
Position: 321-340
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p11
Chemical type: Peptide from protein
Sequence: YWWVQETQIYPNHSSPCLEQ
Position: 81-100
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p11
Chemical type: Peptide from protein
Sequence: YWWVQETQIYPNHSSPCLEQ
Position: 81-100
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p23
Chemical type: Peptide from protein
Sequence: HQVILGVIGGMLVAEAFEHT
Position: 177-196
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p29
Chemical type: Peptide from protein
Sequence: LRVLNIDLLWSVPIAKKWCA
Position: 225-244
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p29
Chemical type: Peptide from protein
Sequence: LRVLNIDLLWSVPIAKKWCA
Position: 225-244
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p32
Chemical type: Peptide from protein
Sequence: IHIDTTPFAGLVRNLGVLFG
Position: 249-268
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p46
Chemical type: Peptide from protein
Sequence: GKTGTIVYQRGVLLPQK
Position: 270-286
Source molecule (GenBank): ACR15721.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p31
Chemical type: Peptide from protein
Sequence: PGGAISNMYAMMIARFKMFP
Position: 241-260
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p57
Chemical type: Peptide from protein
Sequence: TGALASCMGLIYNRMGTVTT
Position: 121-140
Source molecule (GenBank): AAG01222.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p66
Chemical type: Peptide from protein
Sequence: AGSSEQAAEAMEVANQTRQM
Position: 193-212
Source molecule (GenBank): AEW25640.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p68
Chemical type: Peptide from protein
Sequence: TRQMVHAMRTIGTHPSSSAG
Position: 209-228
Source molecule (GenBank): AEW25640.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p15
Chemical type: Peptide from protein
Sequence: DVMNILLQYVVKSFDRSTKV
Position: 113-132
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p35
Chemical type: Peptide from protein
Sequence: LIAFTSEHSHFSLKKGAAAL
Position: 273-292
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p3
Chemical type: Peptide from protein
Sequence: KDYRAYYTFLNFMSNVGDPR
Position: 17-36
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p31
Chemical type: Peptide from protein
Sequence: KWCANPDWIHIDTTPFAGLV
Position: 241-260
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p39
Chemical type: Peptide from protein
Sequence: QLYHFLQIPTHEEHLFYVLS
Position: 305-324
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p54
Chemical type: Peptide from protein
Sequence: VKLYKKLKREITFHGAKEVS
Position: 97-116
Source molecule (GenBank): AEW25640.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p47
Chemical type: Peptide from protein
Sequence: VYQRGVLLPQKVWCASG
Position: 276-292
Source molecule (GenBank): ACR15721.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p68
Chemical type: Peptide from protein
Sequence: TQEAINKITKNLNSLSE
Position: 402-418
Source molecule (GenBank): ACR15721.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p75
Chemical type: Peptide from protein
Sequence: KVDDLRADTISSQIELA
Position: 444-460
Source molecule (GenBank): P03460.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p43
Chemical type: Peptide from protein
Sequence: GTTVYGAFDPLLAVADICKK
Position: 337-356
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p62
Chemical type: Peptide from protein
Sequence: EGYEMVFDGKPQHTNVCFWY
Position: 489-508
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p6
Chemical type: Peptide from protein
Sequence: APFLDRLRRDQKSLKGR
Position: 30-46
Source molecule (GenBank): Q77ZM3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p19
Chemical type: Peptide from protein
Sequence: CFPIMHDRTKIRQLPNL
Position: 109-125
Source molecule (GenBank): P03460.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p37
Chemical type: Peptide from protein
Sequence: KNLYGDSNPQKFTSSAN
Position: 216-232
Source molecule (GenBank): ACR15721.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p44
Chemical type: Peptide from protein
Sequence: GRIVVDYMVQKPGKTGT
Position: 258-274
Source molecule (GenBank): P03460.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p11
Chemical type: Peptide from protein
Sequence: SCSKVDVNYAFLHATDLLPA
Position: 81-100
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p23
Chemical type: Peptide from protein
Sequence: RYFNQLSTGLDMVGLAADWL
Position: 177-196
Source molecule (GenBank): Q05329.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p6
Chemical type: Peptide from protein
Sequence: IYFPLCFQFNQTVGTKMIWV
Position: 41-60
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: p32
Chemical type: Peptide from protein
Sequence: TLVEPGDKITFEATGNLVVP
Position: 249-268
Source molecule (GenBank): ADU02154.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo