Reference: Julia Lederhofer; Andrew J Borst; Lam Nguyen; Rebecca A Gillespie; Connor J Williams; Emma L Walker; Julie E Raab; Christina Yap; Daniel Ellis; Adrian Creanga; Hyon-Xhi Tan; Thi H T Do; Michelle Ravichandran; Adrian B McDermott; Valerie Le Sage; Sarah F Andrews; Barney S Graham; Adam K Wheatley; Douglas S Reed; Neil P King; Masaru Kanekiyo. "Structural convergence and water-mediated substrate mimicry enable broad neuraminidase inhibition by human antibodies." Nature communications (2025).

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1 Fab on Influenza N5NA
Chemical type: Discontinuous protein residues
Discontinuous residues: E116, N144, V146, K147, D148, R149, W176, S177, D196, D197, Q219, I220, E225, P243, A244, N245, S246, R290, N292, N345, Y346, R370, Y404
Source molecule (GenBank): ABB19465.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of NCS.1.1 Fab on Influenza N1NA
Chemical type: Discontinuous protein residues
Discontinuous residues: R118, I149, K150, D151, R152, W179, S180, N200, N222, I223, E228, P246, S247, N248, G249, Q250, R293, N295, W296, A343, N344, R368, Y402, R430
Source molecule (GenBank): ACP41107.1
Assay category: BCell
Result: Positive
Host: M