Reference: Clinton O Ogega; Nicole E Skinner; Marta V Schoenle; Xander E Wilcox; Nicole Frumento; Desiree A Wright; Harry T Paul; Ariadne Sinnis-Bourozikas; Kaitlyn E Clark; Alexis Figueroa; Pamela J Bjorkman; Stuart C Ray; Andrew I Flyak; Justin R Bailey. "Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance." Immunity (2024).

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.59
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab55 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.13
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab64 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: L249, C251, N252, D253, S254, L255, H256, T257, G258, F259, L260, A262, F264, Y265, K268, F269, N270, W351, E353, L437, W438, P441
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.12
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab40 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: H267, K268, F269, F408, R409, T426, R428, C429, L437, V444, N445, F446, T447, I448, F449, K450, V451, R452, C466
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive-Intermediate
Host: M

Epitope: Epitope of Fab hcab17 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: R246, Y296, Q315, V336, R343, F344, G345, A346, P347, I360, N362, N363, T364, R365, P367, Q368, G369, N370, G456
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.31
Host: M

Epitope: Epitope of Fab hcab17 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: R246, Y296, Q315, V336, R343, F344, G345, A346, P347, I360, N362, N363, T364, R365, P367, Q368, G369, N370, G456
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of Fab hcab17 on HCV 1b09 E2
Chemical type: Discontinuous protein residues
Discontinuous residues: R246, Y296, Q315, V336, R343, F344, G345, A346, P347, I360, N362, N363, T364, R365, P367, Q368, G369, N370, G456
Source molecule (GenBank): AHV90290.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-Low
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive-High
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M

Epitope: FRLYko E2
Chemical type: Discontinuous protein residues
Discontinuous residues: T247, L249, N250, S254, G258, W259, G352, D357
Source molecule (GenBank): AHV90281.1
Assay category: BCell
Result: Positive
Host: M