Reference: Jia Duan; Peiyu Xu; Xiaodong Luan; Yujie Ji; Xinheng He; Ning Song; Qingning Yuan; Ye Jin; Xi Cheng; Hualiang Jiang; Jie Zheng; Shuyang Zhang; Yi Jiang; H Eric Xu. "Hormone- and antibody-mediated activation of the thyrotropin receptor." Nature (2022).

Epitope: Epitope of M22 scFv on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E34, E35, R38, K58, S79, R80, Y82, I85, T104, H105, E107, R109, N110, K129, F130, F153, I155, E157, T159, K183, Y185, N208, K209, Q235, R255, N256, R274, D276
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: M 19 years

Epitope: Epitope of M22 scFv on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E34, E35, R38, K58, S79, R80, Y82, I85, T104, H105, E107, R109, N110, K129, F130, F153, I155, E157, T159, K183, Y185, N208, K209, Q235, R255, N256, R274, D276
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: M 19 years

Epitope: Epitope of M22 scFv on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E34, E35, R38, K58, S79, R80, Y82, I85, T104, H105, E107, R109, N110, K129, F130, F153, I155, E157, T159, K183, Y185, N208, K209, Q235, R255, N256, R274, D276
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: M 19 years

Epitope: Epitope of K1-70 Fab on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E35, F153
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: F 54 years

Epitope: Epitope of K1-70 Fab on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E35, F153
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: F 54 years

Epitope: Epitope of K1-70 Fab on thyrotropin receptor
Chemical type: Discontinuous protein residues
Discontinuous residues: E35, F153
Source molecule (GenBank): P16473.2
Assay category: BCell
Result: Positive
Host: F 54 years

Epitope: Epitope of nanobody 35 on Gα (s) protein
Chemical type: Discontinuous protein residues
Discontinuous residues: D229, E230, R231, R232, I235, N254, Q267, E268, N271, L272, S275, I276, N278, N279, R283, D310, Y311, P313, E314
Source molecule (GenBank): P63092.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 35 on Gα (s) protein
Chemical type: Discontinuous protein residues
Discontinuous residues: D229, E230, R231, R232, I235, N254, Q267, E268, N271, L272, S275, I276, N278, N279, R283, D310, Y311, P313, E314
Source molecule (GenBank): P63092.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 35 on Gß1 protein
Chemical type: Discontinuous protein residues
Discontinuous residues: R8, E12, K15, T184, C204, D205, A206, T223, H225, E226, S227, D228, D246, I270
Source molecule (GenBank): P54311.4
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 35 on Gß1 protein
Chemical type: Discontinuous protein residues
Discontinuous residues: R8, E12, K15, T184, C204, D205, A206, T223, H225, E226, S227, D228, D246, I270
Source molecule (GenBank): P54311.4
Assay category: BCell
Result: Positive