Reference: Jing Chen; Yue Wang; Xinquan Wang. "Structures of clinical antibodies bound to IL-33 uncover two distinct epitopes underlying differential efficacy." mAbs (2026).

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000329

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 406000.0

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.51

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Tozorakimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: L123, T135, F136, A137, L138, E139, D140, E148, L150, K151, K152, D153, E154, K155, D157, K158, L160, S187, P188, T189, K190
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.81

Epitope: Epitope of Etokimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, E165, Q167, H168, N171, D178, G179, K180, L182, L220, H221, N222, S225, N226, N257
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Etokimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, E165, Q167, H168, N171, D178, G179, K180, L182, L220, H221, N222, S225, N226, N257
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.127

Epitope: Epitope of Etokimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, E165, Q167, H168, N171, D178, G179, K180, L182, L220, H221, N222, S225, N226, N257
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Etokimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, E165, Q167, H168, N171, D178, G179, K180, L182, L220, H221, N222, S225, N226, N257
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 353000.0

Epitope: Epitope of Etokimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, E165, Q167, H168, N171, D178, G179, K180, L182, L220, H221, N222, S225, N226, N257
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000448

Epitope: Epitope of Itepekimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, Y122, A124, Y163, E165, D178, G179, K180, M181, L182, L220, H221, N222, M223, H224, N226, L267, S268, E269
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Itepekimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, Y122, A124, Y163, E165, D178, G179, K180, M181, L182, L220, H221, N222, M223, H224, N226, L267, S268, E269
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Itepekimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, Y122, A124, Y163, E165, D178, G179, K180, M181, L182, L220, H221, N222, M223, H224, N226, L267, S268, E269
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0821

Epitope: Epitope of Itepekimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, Y122, A124, Y163, E165, D178, G179, K180, M181, L182, L220, H221, N222, M223, H224, N226, L267, S268, E269
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 389000.0

Epitope: Epitope of Itepekimab on IL-33
Chemical type: Discontinuous protein residues
Discontinuous residues: I119, T120, Y122, A124, Y163, E165, D178, G179, K180, M181, L182, L220, H221, N222, M223, H224, N226, L267, S268, E269
Source molecule (GenBank): O95760.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000319