Reference: Nadine L Dudek; Shannon Maier; Zhen-Jun Chen; Philip A Mudd; Stuart I Mannering; David C Jackson; Weiguang Zeng; Catherine L Keech; Kassie Hamlin; Zi-jian Pan; Karen Davis-Schwarz; Jennifer Workman-Azbill; Michael Bachmann; James McCluskey; A Darise Farris. "T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201." Arthritis and rheumatism (2007).

Epitope: Human La 34-48
Chemical type: Peptide from protein
Sequence: KFLKEQIKLDEGWVP
Position: 34-48
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 34-48
Chemical type: Peptide from protein
Sequence: KFLKEQIKLDEGWVP
Position: 34-48
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 46-60
Chemical type: Peptide from protein
Sequence: WVPLEIMIKFNRLNR
Position: 46-60
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 46-60
Chemical type: Peptide from protein
Sequence: WVPLEIMIKFNRLNR
Position: 46-60
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 46-60
Chemical type: Peptide from protein
Sequence: WVPLEIMIKFNRLNR
Position: 46-60
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 58-72
Chemical type: Peptide from protein
Sequence: LNRLTTDFNVIVEAL
Position: 58-72
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 58-72
Chemical type: Peptide from protein
Sequence: LNRLTTDFNVIVEAL
Position: 58-72
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 58-72
Chemical type: Peptide from protein
Sequence: LNRLTTDFNVIVEAL
Position: 58-72
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 67-81
Chemical type: Peptide from protein
Sequence: VIVEALSKSKAELME
Position: 67-81
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 67-81
Chemical type: Peptide from protein
Sequence: VIVEALSKSKAELME
Position: 67-81
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 196-210
Chemical type: Peptide from protein
Sequence: RKQNKVEAKLRAKQE
Position: 196-210
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 196-210
Chemical type: Peptide from protein
Sequence: RKQNKVEAKLRAKQE
Position: 196-210
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 214-228
Chemical type: Peptide from protein
Sequence: KQKLEEDAEMKSLEE
Position: 214-228
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 214-228
Chemical type: Peptide from protein
Sequence: KQKLEEDAEMKSLEE
Position: 214-228
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 229-243
Chemical type: Peptide from protein
Sequence: KIGCLLKFSGDLDDQ
Position: 229-243
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 229-243
Chemical type: Peptide from protein
Sequence: KIGCLLKFSGDLDDQ
Position: 229-243
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 286-300
Chemical type: Peptide from protein
Sequence: AKDANNGNLQLRNKE
Position: 286-300
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 286-300
Chemical type: Peptide from protein
Sequence: AKDANNGNLQLRNKE
Position: 286-300
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 296-310
Chemical type: Peptide from protein
Sequence: LRNKEVTWEVLEGEV
Position: 296-310
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 296-310
Chemical type: Peptide from protein
Sequence: LRNKEVTWEVLEGEV
Position: 296-310
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 304-318
Chemical type: Peptide from protein
Sequence: EVLEGEVEKEALKKI
Position: 304-318
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 304-318
Chemical type: Peptide from protein
Sequence: EVLEGEVEKEALKKI
Position: 304-318
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 312-326
Chemical type: Peptide from protein
Sequence: KEALKKIIEDQQESL
Position: 312-326
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 312-326
Chemical type: Peptide from protein
Sequence: KEALKKIIEDQQESL
Position: 312-326
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 314-328
Chemical type: Peptide from protein
Sequence: ALKKIIEDQQESLNK
Position: 314-328
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 314-328
Chemical type: Peptide from protein
Sequence: ALKKIIEDQQESLNK
Position: 314-328
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 316-330
Chemical type: Peptide from protein
Sequence: KKIIEDQQESLNKWK
Position: 316-330
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 316-330
Chemical type: Peptide from protein
Sequence: KKIIEDQQESLNKWK
Position: 316-330
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 344-358
Chemical type: Peptide from protein
Sequence: KAAQPGSGKGKVQFQ
Position: 344-358
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 344-358
Chemical type: Peptide from protein
Sequence: KAAQPGSGKGKVQFQ
Position: 344-358
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 352-366
Chemical type: Peptide from protein
Sequence: KGKVQFQGKKTKFAS
Position: 352-366
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 352-366
Chemical type: Peptide from protein
Sequence: KGKVQFQGKKTKFAS
Position: 352-366
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 360-374
Chemical type: Peptide from protein
Sequence: KKTKFASDDEHDEHD
Position: 360-374
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 360-374
Chemical type: Peptide from protein
Sequence: KKTKFASDDEHDEHD
Position: 360-374
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 364-378
Chemical type: Peptide from protein
Sequence: FASDDEHDEHDENGA
Position: 364-378
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 364-378
Chemical type: Peptide from protein
Sequence: FASDDEHDEHDENGA
Position: 364-378
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 368-382
Chemical type: Peptide from protein
Sequence: DEHDEHDENGATGPV
Position: 368-382
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 368-382
Chemical type: Peptide from protein
Sequence: DEHDEHDENGATGPV
Position: 368-382
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 55-69
Chemical type: Peptide from protein
Sequence: FNRLNRLTTDFNVIV
Position: 55-69
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 55-69
Chemical type: Peptide from protein
Sequence: FNRLNRLTTDFNVIV
Position: 55-69
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 64-78
Chemical type: Peptide from protein
Sequence: DFNVIVEALSKSKAE
Position: 64-78
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 64-78
Chemical type: Peptide from protein
Sequence: DFNVIVEALSKSKAE
Position: 64-78
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 91-105
Chemical type: Peptide from protein
Sequence: RSPSKPLPEVTDEYK
Position: 91-105
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 91-105
Chemical type: Peptide from protein
Sequence: RSPSKPLPEVTDEYK
Position: 91-105
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 115-129
Chemical type: Peptide from protein
Sequence: IKGFPTDATLDDIKE
Position: 115-129
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 115-129
Chemical type: Peptide from protein
Sequence: IKGFPTDATLDDIKE
Position: 115-129
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 136-150
Chemical type: Peptide from protein
Sequence: QVLNIQMRRTLHKAF
Position: 136-150
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 136-150
Chemical type: Peptide from protein
Sequence: QVLNIQMRRTLHKAF
Position: 136-150
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 139-153
Chemical type: Peptide from protein
Sequence: NIQMRRTLHKAFKGS
Position: 139-153
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 139-153
Chemical type: Peptide from protein
Sequence: NIQMRRTLHKAFKGS
Position: 139-153
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 166-180
Chemical type: Peptide from protein
Sequence: KFVETPGQKYKETDL
Position: 166-180
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 166-180
Chemical type: Peptide from protein
Sequence: KFVETPGQKYKETDL
Position: 166-180
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 172-186
Chemical type: Peptide from protein
Sequence: GQKYKETDLLILFKD
Position: 172-186
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 172-186
Chemical type: Peptide from protein
Sequence: GQKYKETDLLILFKD
Position: 172-186
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 208-222
Chemical type: Peptide from protein
Sequence: KQEQEAKQKLEEDAE
Position: 208-222
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 208-222
Chemical type: Peptide from protein
Sequence: KQEQEAKQKLEEDAE
Position: 208-222
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 211-225
Chemical type: Peptide from protein
Sequence: QEAKQKLEEDAEMKS
Position: 211-225
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 211-225
Chemical type: Peptide from protein
Sequence: QEAKQKLEEDAEMKS
Position: 211-225
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 244-258
Chemical type: Peptide from protein
Sequence: TCREDLHILFSNHGE
Position: 244-258
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 244-258
Chemical type: Peptide from protein
Sequence: TCREDLHILFSNHGE
Position: 244-258
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 362-376
Chemical type: Peptide from protein
Sequence: TKFASDDEHDEHDEN
Position: 362-376
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 362-376
Chemical type: Peptide from protein
Sequence: TKFASDDEHDEHDEN
Position: 362-376
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 46-64
Chemical type: Peptide from protein
Sequence: WVPLEIMIKFNRLNRLTTD
Position: 46-64
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 151-168
Chemical type: Peptide from protein
Sequence: KGSIFVVFDSIESAKKFV
Position: 151-168
Source molecule (GenBank): P05455.2
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: other
Culture conditions: Direct Ex Vivo

Epitope: Human La 310-324
Chemical type: Peptide from protein
Sequence: VEKEALKKIIEDQQE
Position: 310-324
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Human La 310-324
Chemical type: Peptide from protein
Sequence: VEKEALKKIIEDQQE
Position: 310-324
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 308-322
Chemical type: Peptide from protein
Sequence: GEVEKEALKKIIEDQ
Position: 308-322
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 308-322
Chemical type: Peptide from protein
Sequence: GEVEKEALKKIIEDQ
Position: 308-322
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 306-320
Chemical type: Peptide from protein
Sequence: LEGEVEKEALKKIIE
Position: 306-320
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 306-320
Chemical type: Peptide from protein
Sequence: LEGEVEKEALKKIIE
Position: 306-320
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 220-234
Chemical type: Peptide from protein
Sequence: DAEMKSLEEKIGCLL
Position: 220-234
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 220-234
Chemical type: Peptide from protein
Sequence: DAEMKSLEEKIGCLL
Position: 220-234
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 217-231
Chemical type: Peptide from protein
Sequence: LEEDAEMKSLEEKIG
Position: 217-231
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 217-231
Chemical type: Peptide from protein
Sequence: LEEDAEMKSLEEKIG
Position: 217-231
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 205-249
Chemical type: Peptide from protein
Sequence: LRAKQEQEAKQKLEE
Position: 205-219
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 205-249
Chemical type: Peptide from protein
Sequence: LRAKQEQEAKQKLEE
Position: 205-219
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 160-174
Chemical type: Peptide from protein
Sequence: SIESAKKFVETPGQK
Position: 160-174
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 160-174
Chemical type: Peptide from protein
Sequence: SIESAKKFVETPGQK
Position: 160-174
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 157-171
Chemical type: Peptide from protein
Sequence: VFDSIESAKKFVETP
Position: 157-171
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 157-171
Chemical type: Peptide from protein
Sequence: VFDSIESAKKFVETP
Position: 157-171
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 148-162
Chemical type: Peptide from protein
Sequence: KAFKGSIFVVFDSIE
Position: 148-162
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 148-162
Chemical type: Peptide from protein
Sequence: KAFKGSIFVVFDSIE
Position: 148-162
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 145-159
Chemical type: Peptide from protein
Sequence: TLHKAFKGSIFVVFD
Position: 145-159
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 145-159
Chemical type: Peptide from protein
Sequence: TLHKAFKGSIFVVFD
Position: 145-159
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 51-75
Chemical type: Peptide from protein
Sequence: IMIKFNRLNRLTTDFNVIVEALSKS
Position: 51-75
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 51-75
Chemical type: Peptide from protein
Sequence: IMIKFNRLNRLTTDFNVIVEALSKS
Position: 51-75
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative

Epitope: Human La 52-66
Chemical type: Peptide from protein
Sequence: MIKFNRLNRLTTDFN
Position: 52-66
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 52-66
Chemical type: Peptide from protein
Sequence: MIKFNRLNRLTTDFN
Position: 52-66
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 49-63
Chemical type: Peptide from protein
Sequence: LEIMIKFNRLNRLTT
Position: 49-63
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 49-63
Chemical type: Peptide from protein
Sequence: LEIMIKFNRLNRLTT
Position: 49-63
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 43-57
Chemical type: Peptide from protein
Sequence: DEGWVPLEIMIKFNR
Position: 43-57
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 43-57
Chemical type: Peptide from protein
Sequence: DEGWVPLEIMIKFNR
Position: 43-57
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 40-54
Chemical type: Peptide from protein
Sequence: IKLDEGWVPLEIMIK
Position: 40-54
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 40-54
Chemical type: Peptide from protein
Sequence: IKLDEGWVPLEIMIK
Position: 40-54
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 37-51
Chemical type: Peptide from protein
Sequence: KEQIKLDEGWVPLEI
Position: 37-51
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Human La 37-51
Chemical type: Peptide from protein
Sequence: KEQIKLDEGWVPLEI
Position: 37-51
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 22-36
Chemical type: Peptide from protein
Sequence: EYYFGDFNLPRDKFL
Position: 22-36
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Positive

Epitope: Human La 22-36
Chemical type: Peptide from protein
Sequence: EYYFGDFNLPRDKFL
Position: 22-36
Source molecule (GenBank): P05455.2
Assay category: MhcBinding
Result: Negative