Reference: Joost Neijssen; Rosa M F Cardoso; Kristen M Chevalier; Luus Wiegman; Thomas Valerius; G Mark Anderson; Sheri L Moores; Janine Schuurman; Paul W H I Parren; William R Strohl; Mark L Chiu. "Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET." The Journal of biological chemistry (2021).

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive
Quantitative measurement: 3.1

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive
Quantitative measurement: 1.26

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000267

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive
Quantitative measurement: 212000.0

Epitope: Epitope of  anti-Met Fab arm from amivantamab on MET
Chemical type: Discontinuous protein residues
Discontinuous residues: D94, F96, P97, C98, Q99, D100, S103, K104, A105, N106, H159, C160, F162, S163, P164, I166, E167, T222, D224
Source molecule (GenBank): P08581.4
Assay category: BCell
Result: Positive

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of anti-EGFR arm of amivantamab on EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: K489, I491
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive