Reference: Cheuk Wun Li; Roman Osman; Francesca Menconi; Erlinda S Concepcion; Yaron Tomer. "Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes." Journal of autoimmunity (2017).

Epitope: GAD.492
Chemical type: Peptide from protein
Sequence: REGYEMVFDGKPQHTNVCF
Position: 322-340
Source molecule (GenBank): Q9UGI5.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: GAD.492
Chemical type: Peptide from protein
Sequence: REGYEMVFDGKPQHTNVCF
Position: 322-340
Source molecule (GenBank): Q9UGI5.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: GAD.492
Chemical type: Peptide from protein
Sequence: REGYEMVFDGKPQHTNVCF
Position: 322-340
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Positive

Epitope: TPO.758
Chemical type: Peptide from protein
Sequence: ESGRRVLVYSCRHGYELQG
Position: 758-776
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Positive-High
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.758
Chemical type: Peptide from protein
Sequence: ESGRRVLVYSCRHGYELQG
Position: 758-776
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.758
Chemical type: Peptide from protein
Sequence: ESGRRVLVYSCRHGYELQG
Position: 758-776
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Positive

Epitope: TPO.338
Chemical type: Peptide from protein
Sequence: RQLRNWTSAEGLLRVHARL
Position: 338-356
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Positive-Low
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.338
Chemical type: Peptide from protein
Sequence: RQLRNWTSAEGLLRVHARL
Position: 338-356
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.338
Chemical type: Peptide from protein
Sequence: RQLRNWTSAEGLLRVHARL
Position: 338-356
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Positive

Epitope: Tg.1951
Chemical type: Peptide from protein
Sequence: FRKKVILEDKVKNF
Position: 1951-1964
Source molecule (GenBank): P01266.5
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Tg.1951
Chemical type: Peptide from protein
Sequence: FRKKVILEDKVKNF
Position: 1951-1964
Source molecule (GenBank): P01266.5
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Tg.1951
Chemical type: Peptide from protein
Sequence: FRKKVILEDKVKNF
Position: 1951-1964
Source molecule (GenBank): P01266.5
Assay category: MhcBinding
Result: Positive

Epitope: Ins.76
Chemical type: Peptide from protein
Sequence: PGAGSLQPLALEGSLQKRG
Position: 72-90
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Ins.76
Chemical type: Peptide from protein
Sequence: PGAGSLQPLALEGSLQKRG
Position: 72-90
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Ins.76
Chemical type: Peptide from protein
Sequence: PGAGSLQPLALEGSLQKRG
Position: 72-90
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive

Epitope: GAD.378
Chemical type: Peptide from protein
Sequence: SRKHKWKLSGVERANSVTW
Position: 208-226
Source molecule (GenBank): Q9UGI5.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: GAD.378
Chemical type: Peptide from protein
Sequence: SRKHKWKLSGVERANSVTW
Position: 208-226
Source molecule (GenBank): Q9UGI5.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: GAD.378
Chemical type: Peptide from protein
Sequence: SRKHKWKLSGVERANSVTW
Position: 208-226
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Positive

Epitope: TPO.161
Chemical type: Peptide from protein
Sequence: RDHPRWGASNTALARWLPP
Position: 161-179
Source molecule (GenBank): AAA61216.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.161
Chemical type: Peptide from protein
Sequence: RDHPRWGASNTALARWLPP
Position: 161-179
Source molecule (GenBank): AAA61216.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.161
Chemical type: Peptide from protein
Sequence: RDHPRWGASNTALARWLPP
Position: 161-179
Source molecule (GenBank): AAA61216.1
Assay category: MhcBinding
Result: Positive

Epitope: TPO.344
Chemical type: Peptide from protein
Sequence: TSAEGLLRVHARLRDSGRA
Position: 344-362
Source molecule (GenBank): AAA61216.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.344
Chemical type: Peptide from protein
Sequence: TSAEGLLRVHARLRDSGRA
Position: 344-362
Source molecule (GenBank): AAA61216.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.344
Chemical type: Peptide from protein
Sequence: TSAEGLLRVHARLRDSGRA
Position: 344-362
Source molecule (GenBank): AAA61216.1
Assay category: MhcBinding
Result: Positive

Epitope: TPO.489
Chemical type: Peptide from protein
Sequence: AAFRFGHATIHPLVRRLDASFQEH
Position: 488-511
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.489
Chemical type: Peptide from protein
Sequence: AAFRFGHATIHPLVRRLDASFQEH
Position: 488-511
Source molecule (GenBank): P07202.4
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TPO.489
Chemical type: Peptide from protein
Sequence: AAFRFGHATIHPLVRRLDASFQEH
Position: 488-511
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Positive

Epitope: Tg.726
Chemical type: Peptide from protein
Sequence: CPTPCQLQAEQAFLRTV
Position: 726-742
Source molecule (GenBank): BAG64665.1
Assay category: MhcBinding
Result: Negative

Epitope: Tg.202
Chemical type: Peptide from protein
Sequence: VNTTDMMIFDLVHSYNRFPD
Position: 197-216
Source molecule (GenBank): P01266.5
Assay category: MhcBinding
Result: Negative

Epitope: TSHR.132
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): P16473.2
Assay category: MhcBinding
Result: Negative

Epitope: TSHR.197
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): P16473.2
Assay category: MhcBinding
Result: Negative

Epitope: Ins B9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Ins.44
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTR
Position: 44-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Ins.25
Chemical type: Peptide from protein
Sequence: FVNQHLCGSHLVEA
Position: 25-38
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Ins.89
Chemical type: Peptide from protein
Sequence: RGIVEQCCTSICSL
Position: 89-102
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Ins.98
Chemical type: Peptide from protein
Sequence: SICSLYQLENYCN
Position: 98-110
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.116
Chemical type: Peptide from protein
Sequence: QDVMNILLQYVVKSFDRST
Position: 112-130
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.247
Chemical type: Peptide from protein
Sequence: NMYAMMIARFKMFPEVKEKG
Position: 81-100
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.260
Chemical type: Peptide from protein
Sequence: PEVKEKGMAALPRLIAFTSE
Position: 94-113
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.274
Chemical type: Peptide from protein
Sequence: IAFTSEHSHFSLK
Position: 108-120
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.379
Chemical type: Peptide from protein
Sequence: WKLSGVERANSV
Position: 213-224
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.555
Chemical type: Peptide from protein
Sequence: NFFRMVISNPAAT
Position: 389-401
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.192
Chemical type: Peptide from protein
Sequence: AADWLTSTANTNMFT
Position: 26-40
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD.456
Chemical type: Peptide from protein
Sequence: WLMWRAKGTTGFEAH
Position: 290-304
Source molecule (GenBank): Q9UGI5.1
Assay category: MhcBinding
Result: Negative

Epitope: TPO.763
Chemical type: Peptide from protein
Sequence: SGRRVLVYSCRHGYELQGR
Position: 759-777
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.122
Chemical type: Peptide from protein
Sequence: ALSEDLLSIIANMSGCLPY
Position: 118-136
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.28
Chemical type: Peptide from protein
Sequence: SRGKELLWGKPEESRVSSV
Position: 24-42
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.423
Chemical type: Peptide from protein
Sequence: ALNAHWSADAVYQEARKVV
Position: 423-441
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.405
Chemical type: Peptide from protein
Sequence: ALHTLWLREHNRLAAALKA
Position: 405-423
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.513
Chemical type: Peptide from protein
Sequence: DLPGLWLHQAFFSPWTLLR
Position: 513-531
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative

Epitope: TPO.351
Chemical type: Peptide from protein
Sequence: RVHARLRDSGRAYLPFVPP
Position: 351-369
Source molecule (GenBank): P07202.4
Assay category: MhcBinding
Result: Negative