Reference: Yoshihiko Sakurai; David D Brand; Bo Tang; Edward F Rosloniec; John M Stuart; Andrew H Kang; Linda K Myers. "Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice." Arthritis research & therapy (2006).

Epitope: CII(251-270)
Chemical type: Peptide from protein
Sequence: PKGQTGEPGIAGFKGEQGPK
Position: 451-470
Source molecule (GenBank): P02458.3
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CII(256-276)
Chemical type: Peptide from protein
Sequence: GEPGIAGFKGEQGPKGEPGPA
Position: 456-476
Source molecule (GenBank): P02458.3
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CII(256-276)
Chemical type: Peptide from protein
Sequence: GEPGIAGFKGEQGPKGEPGPA
Position: 456-476
Source molecule (GenBank): P02458.3
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CII(256-276)
Chemical type: Peptide from protein
Sequence: GEPGIAGFKGEQGPKGEPGPA
Position: 456-476
Source molecule (GenBank): P02458.3
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: CII(256-276)
Chemical type: Peptide from protein
Sequence: GEPGIAGFKGEQGPKGEPGPA
Position: 456-476
Source molecule (GenBank): P02458.3
Assay category: MhcBinding
Result: Positive

Epitope: 263A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGAKGEQGPKGEPGPA
Assay category: MhcBinding
Result: Negative

Epitope: 263N analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGEQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 263N analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGEQGPKGEPGPA
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 263N analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGEQGPKGEPGPA
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 263N analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGEQGPKGEPGPA
Assay category: MhcBinding
Result: Negative

Epitope: 264A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFAGEQGPKGEPGPA
Assay category: MhcBinding
Result: Positive-Low

Epitope: 265A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKAEQGPKGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGAQGPKGEPGPA
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGAQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGAQGPKGEPGPA
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGAQGPKGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: MhcBinding
Result: Positive-Low

Epitope: 267T analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGETGPKGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 268A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGEQAPKGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 269A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGEQGAKGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 270A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFAGEQGPAGEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 271A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGEQGPKAEPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 272A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGEQGPKGAPGPA
Assay category: MhcBinding
Result: Positive

Epitope: 263N,266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGAQGPKGEPGPA
Assay category: TCell
Result: Positive

Epitope: 263N,266A analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGAQGPKGEPGPA
Assay category: MhcBinding
Result: Negative

Epitope: 263N,266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: TCell
Result: Positive

Epitope: 263N,266D analog to CII(256-276)
Chemical type: Peptide, no natural source
Sequence: GEPGIAGFKGDQGPKGEPGPA
Assay category: MhcBinding
Result: Negative

Epitope: PKGQTGEPGAAGFKGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGAAGFKGEQGPK
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIPGFKGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIPGFKGEQGPK
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAAFKGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAAFKGEQGPK
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGNKGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGNKGEQGPK
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGAKGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGAKGEQGPK
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFAGEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFAGEQGPK
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKAEQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKAEQGPK
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGDQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGDQGPK
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGAQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGAQGPK
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGETGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGETGPK
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGEQAPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGEQAPK
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGEQGAK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGEQGAK
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGFKGEQGPA
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGFKGEQGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGNKGDQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGNKGDQGPK
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: PKGQTGEPGIAGNKGAQGPK
Chemical type: Peptide, no natural source
Sequence: PKGQTGEPGIAGNKGAQGPK
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A9
Chemical type: Peptide, no natural source
Sequence: GEPGAPGNKGEQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A9
Chemical type: Peptide, no natural source
Sequence: GEPGAPGNKGEQGPKGEPGPA
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A9
Chemical type: Peptide, no natural source
Sequence: GEPGAPGNKGEQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A12
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGDQGPKGEPGPA
Assay category: TCell
Result: Positive-Low
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A12
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGDQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A12
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGDQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A13
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGAQGPKGEPGPA
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A13
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGAQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: A13
Chemical type: Peptide, no natural source
Sequence: GEPGIAGNKGAQGPKGEPGPA
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo