Reference: Lanfang Zhu; Jingtao Pu; Yufen Tao; Lei Shi; Shuyuan Liu; Xinwen Zhang; Weipeng Liu; Ming Sun; Yufeng Yao; Li Shi. "A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses." Cancer biology & medicine (2025).

Epitope: HPV16 E6 86-95
Chemical type: Peptide from protein
Sequence: YCYSLYGTTL
Position: 86-95
Source molecule (GenBank): P03126
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 81-90
Chemical type: Peptide from protein
Sequence: SEYRHYCYSL
Position: 81-90
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-Intermediate
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 75-83
Chemical type: Peptide from protein
Sequence: KFYSKISEY
Position: 75-83
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 124-132
Chemical type: Peptide from protein
Sequence: RHLDKKQRF
Position: 124-132
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-High
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 49-57
Chemical type: Peptide from protein
Sequence: VYDFAFRDL
Position: 49-57
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-Intermediate
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 38-45
Chemical type: Peptide from protein
Sequence: VYCKQQLL
Position: 38-45
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-High
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E7 77-87
Chemical type: Peptide from protein
Sequence: RTLEDLLMGTL
Position: 77-87
Source molecule (GenBank): P03129
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E7 49-57
Chemical type: Peptide from protein
Sequence: RAHYNIVTF
Position: 49-57
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive-High
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E7 50-57
Chemical type: Peptide from protein
Sequence: AHYNIVTF
Position: 50-57
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive-High
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E6 56-70
Chemical type: Peptide from protein
Sequence: DLCIVYRDGNPYAVC
Position: 56-70
Source molecule (GenBank): P03126
Assay category: TCell
Result: Positive-Intermediate
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HPV16 E7 9-23
Chemical type: Peptide from protein
Sequence: HEYMLDLQPETTDLY
Position: 9-23
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive-Intermediate
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo