Reference: Xueling Wu; Zhenhai Zhang; Chaim A Schramm; M Gordon Joyce; Young Do Kwon; Tongqing Zhou; Zizhang Sheng; Baoshan Zhang; Sijy O'Dell; Krisha McKee; Ivelin S Georgiev; Gwo-Yu Chuang; Nancy S Longo; Rebecca M Lynch; Kevin O Saunders; Cinque Soto; Sanjay Srivatsan; Yongping Yang; Robert T Bailer; Mark K Louder; James C Mullikin; Mark Connors; Peter D Kwong; John R Mascola; Lawrence Shapiro. "Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection." Cell (2015).

Epitope: Epitope of 45-VRC01.H03+06.D001739 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: L121, T122, N278, T280, N281, N282, A283, S365, G366, G367, D368, E370, I371, N419, M420, W421, G423, T424, G425, Q426, T449, R450, D451, G452, G453, A454, N455, N456, N459, E460, T461, R463, G466
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.4
Host: M

Epitope: Epitope of 45-VRC01.H03+06.D001739 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: L121, T122, N278, T280, N281, N282, A283, S365, G366, G367, D368, E370, I371, N419, M420, W421, G423, T424, G425, Q426, T449, R450, D451, G452, G453, A454, N455, N456, N459, E460, T461, R463, G466
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of 45-VRC01.H03+06.D001739 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: L121, T122, N278, T280, N281, N282, A283, S365, G366, G367, D368, E370, I371, N419, M420, W421, G423, T424, G425, Q426, T449, R450, D451, G452, G453, A454, N455, N456, N459, E460, T461, R463, G466
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of 45-VRC01.H08.F-117225 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E105, I108, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, R450, D451, G452, G453, A454, N455, T457, N459, T461, R463, N468, K470, R474
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.21

Epitope: Epitope of 45-VRC01.H08.F-117225 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E105, I108, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, R450, D451, G452, G453, A454, N455, T457, N459, T461, R463, N468, K470, R474
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H08.F-117225 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E105, I108, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, R450, D451, G452, G453, A454, N455, T457, N459, T461, R463, N468, K470, R474
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H08.F-117225 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E105, I108, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, R450, D451, G452, G453, A454, N455, T457, N459, T461, R463, N468, K470, R474
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H08.F-117225 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E105, I108, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, R450, D451, G452, G453, A454, N455, T457, N459, T461, R463, N468, K470, R474
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H5.F-185917 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, Q422, G423, R450, D451, G452, G453, A454, N459, E460, G465, G467, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.39

Epitope: Epitope of 45-VRC01.H5.F-185917 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, Q422, G423, R450, D451, G452, G453, A454, N459, E460, G465, G467, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H5.F-185917 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, Q422, G423, R450, D451, G452, G453, A454, N459, E460, G465, G467, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H5.F-185917 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, Q422, G423, R450, D451, G452, G453, A454, N459, E460, G465, G467, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 45-VRC01.H5.F-185917 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, Q422, G423, R450, D451, G452, G453, A454, N459, E460, G465, G467, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC06b on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: T122, T280, N281, N282, A283, K284, S365, G366, G367, D368, E370, I371, N419, M420, W421, R450, D451, G452, G453, A454, N455, N459, E460, T461, G467
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.39

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.78

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08 on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, R454, T456, R458, D463, R465, R469
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VRC08c on HIV-1 gp120 core
Chemical type: Discontinuous protein residues
Discontinuous residues: E101, H104, T105, I108, N272, T274, N275, N276, A277, K278, T358, G359, G360, D361, I364, M415, W416, R418, V419, T444, R445, D446, G447, G448, N449, T450, N451, S452, R454, E455, R458, R465
Source molecule (GenBank): AAM66242.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) on HIV-1
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E276, N277, K279, D280, N281, A282, K283, S364, G365, G366, D367, I370, V427, T452, R453, D454, G455, G456, S457, S458, T459, R467, G470, G471, D472, R474
Source molecule (GenBank): AFE02253.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.9

Epitope: Epitope of 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995) on HIV-1
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, E101, E277, N278, T280, N281, N282, A283, K284, S365, G366, G367, D368, I371, T424, T449, R450, D451, G452, G453, N455, R463, N468, K470
Source molecule (GenBank): Q0ED31.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.69