Reference: T D Jones; W J Phillips; B J Smith; C A Bamford; P D Nayee; T P Baglin; J S H Gaston; M P Baker. "Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII." Journal of thrombosis and haemostasis : JTH (2005).

Epitope: Human FVIII peptide 297
Chemical type: Peptide from protein
Sequence: YSFYSSLISYEEDQR
Position: 1802-1816
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 309
Chemical type: Peptide from protein
Sequence: VQHHMAPTKDEFDCK
Position: 1838-1852
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 321
Chemical type: Peptide from protein
Sequence: LLVCHTNTLNPAHGR
Position: 1874-1888
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 345
Chemical type: Peptide from protein
Sequence: DTLPGLVMAQDQRIR
Position: 1946-1960
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 357
Chemical type: Peptide from protein
Sequence: FTVRKKEEYKMALYN
Position: 1982-1996
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 369
Chemical type: Peptide from protein
Sequence: ECLIGEHLHAGMSTL
Position: 2018-2032
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 381
Chemical type: Peptide from protein
Sequence: FQITASGQYGQWAPK
Position: 2054-2068
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 390
Chemical type: Peptide from protein
Sequence: WSTKEPFSWIKVDLL
Position: 2081-2095
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Human FVIII peptide 402
Chemical type: Peptide from protein
Sequence: ISQFIIMYSLDGKKW
Position: 2117-2131
Source molecule (GenBank): P00451.1
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 414
Chemical type: Peptide from protein
Sequence: GIKHNIFNPPIIARY
Position: 2153-2167
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 426
Chemical type: Peptide from protein
Sequence: DLNSCSMPLGMESKA
Position: 2189-2203
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 438
Chemical type: Peptide from protein
Sequence: SKARLHLQGRSNAWR
Position: 2225-2239
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 462
Chemical type: Peptide from protein
Sequence: GKVKVFQGNQDSFTP
Position: 2297-2311
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 474
Chemical type: Peptide from protein
Sequence: VHQIALRMEVLGCEA
Position: 2333-2347
Source molecule (GenBank): P00451.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Negative

Epitope: Human FVIII peptide 402 M2104K and L2107N
Chemical type: Peptide, no natural source
Sequence: ISQFIIKYSNDGKKW
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Influenza hemagglutinin 307–319
Chemical type: Peptide from protein
Sequence: PKYVKQNTLKLAT
Position: 322-334
Source molecule (GenBank): ABF83447.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Influenza hemagglutinin 307–319
Chemical type: Peptide from protein
Sequence: PKYVKQNTLKLAT
Position: 322-334
Source molecule (GenBank): ABF83447.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Influenza hemagglutinin 307–319
Chemical type: Peptide from protein
Sequence: PKYVKQNTLKLAT
Position: 322-334
Source molecule (GenBank): ABF83447.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Influenza hemagglutinin 307–319
Chemical type: Peptide from protein
Sequence: PKYVKQNTLKLAT
Position: 322-334
Source molecule (GenBank): ABF83447.1
Assay category: MhcBinding
Result: Positive-High

Epitope: M. tuberculosis leprae^-1 hsp 65 2–16
Chemical type: Peptide from protein
Sequence: AKTIAYDEEARRGLE
Position: 49-63
Source molecule (GenBank): AAA25354.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Human myelin basic protein 85–99
Chemical type: Peptide from protein
Sequence: ENPVVHFFKNIVTPR
Position: 218-232
Source molecule (GenBank): EAW66596.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin B 1–15
Chemical type: Peptide from protein
Sequence: FVNQHLCGSHLVEAL
Position: 1-15
Source molecule (GenBank): 1XDA_B
Assay category: MhcBinding
Result: Positive-High