Reference: Hancong Sun; Lingyun Xia; Jianhua Li; Yuanyuan Zhang; Guanying Zhang; Ping Huang; Xingxing Wang; Yue Cui; Ting Fang; Pengfei Fan; Qiang Zhou; Xiangyang Chi; Changming Yu. "A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2." Emerging microbes & infections (2024).

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive
Quantitative measurement: 13.4

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive
Quantitative measurement: 16.5

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.67

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of scFv H4D12 on Omicron BA.5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: I397, R398, N400, E401, Q404, T410, N412, I413, Y416, Y448, L450, F451, R452, K453, N455, Q469, A470, G471, N472, N482, C483, Y484, F485, Q488, Y490, Y496, H500
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-Low