Reference: Cheuk Wun Li; Roman Osman; Francesca Menconi; Erlinda Concepcion; Yaron Tomer. "Cepharanthine blocks TSH receptor peptide presentation by HLA-DR3: Therapeutic implications to Graves' disease." Journal of autoimmunity (2020).

Epitope: TSHR 32-46
Chemical type: Peptide from protein
Sequence: HQEEDFRVTCKDIQR
Position: 32-46
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 51-65
Chemical type: Peptide from protein
Sequence: PPSTQTLKLIETHLR
Position: 51-65
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 53-67
Chemical type: Peptide from protein
Sequence: STQTLKLIETHLRTI
Position: 53-67
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 54-68
Chemical type: Peptide from protein
Sequence: TQTLKLIETHLRTIP
Position: 54-68
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 61-75
Chemical type: Peptide from protein
Sequence: ETHLRTIPSHAFSNL
Position: 61-75
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 76-90
Chemical type: Peptide from protein
Sequence: PNISRIYVSIDVTLQ
Position: 76-90
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 78-94
Chemical type: Peptide from protein
Sequence: ISRIYVSIDVTLQQLES
Position: 78-94
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 80-94
Chemical type: Peptide from protein
Sequence: RIYVSIDVTLQQLES
Position: 80-94
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 95-109
Chemical type: Peptide from protein
Sequence: HSFYNLSKVTHIEIR
Position: 95-109
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 109-124
Chemical type: Peptide from protein
Sequence: RNTRNLTYIDPDALKE
Position: 109-124
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 125-139
Chemical type: Peptide from protein
Sequence: LPLLKFLGIFNTGLK
Position: 125-139
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive-Low
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive-Low
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Positive
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 132-150
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Positive-High

Epitope: TSHR 141-155
Chemical type: Peptide from protein
Sequence: FPDLTKVYSTDIFFI
Position: 141-155
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 145-165
Chemical type: Peptide from protein
Sequence: TKVYSTDIFFILEITDNPYMT
Position: 145-165
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 161-175
Chemical type: Peptide from protein
Sequence: NPYMTSIPVNAFQGL
Position: 161-175
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 175-191
Chemical type: Peptide from protein
Sequence: LCNETLTLKLYNNGFTS
Position: 175-191
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 191-205
Chemical type: Peptide from protein
Sequence: SVQGYAFNGTKLDAV
Position: 191-205
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 192-211
Chemical type: Peptide from protein
Sequence: VQGYAFNGTKLDAVYLNKNK
Position: 192-211
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: TCell
Result: Negative
Host: F 4-6 weeks
Cell type: lymphocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 197-216
Chemical type: Peptide from protein
Sequence: FNGTKLDAVYLNKNKYLTVI
Position: 197-216
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: TSHR 211-225
Chemical type: Peptide from protein
Sequence: KYLTVIDKDAFGGVY
Position: 211-225
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 225-245
Chemical type: Peptide from protein
Sequence: YSGPSLLDVSQTSVTALPSKG
Position: 225-245
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 246-266
Chemical type: Peptide from protein
Sequence: LEHLKELIARNTWTLKKLPLS
Position: 246-266
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 266-280
Chemical type: Peptide from protein
Sequence: SLSFLHLTRADLSYP
Position: 266-280
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 267-281
Chemical type: Peptide from protein
Sequence: LSFLHLTRADLSYPS
Position: 267-281
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 283-297
Chemical type: Peptide from protein
Sequence: CCAFKNQKKIRGILE
Position: 283-297
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 284-303
Chemical type: Peptide from protein
Sequence: CAFKNQKKIRGILESLMCNE
Position: 284-303
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 289-303
Chemical type: Peptide from protein
Sequence: QKKIRGILESLMCNE
Position: 289-303
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 304-318
Chemical type: Peptide from protein
Sequence: SSMQSLRQRKSVNAL
Position: 304-318
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 311-325
Chemical type: Peptide from protein
Sequence: QRKSVNALNSPLHQE
Position: 311-325
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 321-335
Chemical type: Peptide from protein
Sequence: PLHQEYEENLGDSIV
Position: 321-335
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 331-345
Chemical type: Peptide from protein
Sequence: GDSIVGYKEKSKFQD
Position: 331-345
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 337-351
Chemical type: Peptide from protein
Sequence: YKEKSKFQDTHNNAH
Position: 337-351
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 349-363
Chemical type: Peptide from protein
Sequence: NAHYYVFFEEQEDEI
Position: 349-363
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 363-385
Chemical type: Peptide from protein
Sequence: IIGFGQELKNPQEETLQAFDSHY
Position: 363-385
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 385-404
Chemical type: Peptide from protein
Sequence: YDYTICGDSEDMVCTPKSDE
Position: 385-404
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 393-413
Chemical type: Peptide from protein
Sequence: SEDMVCTPKSDEFNPCEDIMG
Position: 393-413
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 399-418
Chemical type: Peptide from protein
Sequence: TPKSDEFNPCEDIMGYKFLR
Position: 399-418
Source molecule (GenBank): AAR07906.1
Assay category: MhcBinding
Result: Negative

Epitope: S53
Chemical type: Other Non-Sequence
Assay category: MhcBinding
Result: Positive