Reference: Rachel L Paterson; Marco P La Manna; Victoria Arena De Souza; Andrew Walker; Dawn Gibbs-Howe; Rakesh Kulkarni; Joannah R Fergusson; Nitha Charles Mulakkal; Mauro Monteiro; Wilawan Bunjobpol; Marcin Dembek; Magdalena Martin-Urdiroz; Tressan Grant; Claire Barber; Diana J Garay-Baquero; Liku Bekele Tezera; David Lowne; Camille Britton-Rivet; Robert Pengelly; Natalia Chepisiuk; Praveen K Singh; Amanda P Woon; Alex S Powlesland; Michelle L McCully; Nadia Caccamo; Mariolina Salio; Giusto Davide Badami; Lucy Dorrell; Andrew Knox; Ross Robinson; Paul Elkington; Francesco Dieli; Marco Lepore; Sarah Leonard; Luis F Godinho. "An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis." Proceedings of the National Academy of Sciences of the United States of America (2024).

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.33

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: TCell
Result: Positive
Quantitative measurement: 0.34

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcLigandElution
Result: Positive

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcLigandElution
Result: Positive

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 180.0

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 231.0

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcBinding
Result: Positive

Epitope: InhA(53-61)
Chemical type: Peptide from protein
Sequence: RLPAKAPLL
Position: 53-61
Source molecule (GenBank): P9WGR1.1
Assay category: MhcBinding
Result: Positive

Epitope: Epitope of TCR on HLA-E complex
Chemical type: Discontinuous protein residues
Discontinuous residues: R83, R86, R89, D90, Q93, I94, V97, R100, D170, A171, S172, E175, H176, A179, D183, E187
Source molecule (GenBank): P13747.3
Assay category: TCell
Result: Positive
Quantitative measurement: 2.33

Epitope: Epitope of TCR on HLA-E complex
Chemical type: Discontinuous protein residues
Discontinuous residues: R83, R86, R89, D90, Q93, I94, V97, R100, D170, A171, S172, E175, H176, A179, D183, E187
Source molecule (GenBank): P13747.3
Assay category: TCell
Result: Positive
Quantitative measurement: 0.34

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 187.0

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 173.0

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader A2 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLVL
Position: 3-11
Source molecule (GenBank): P01892.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 178.0

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 166.0

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader Cw3 (3-11)
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): AAB02773.1
Assay category: MhcBinding
Result: Positive

Epitope: Rv2997 (470-478)
Chemical type: Peptide from protein
Sequence: RMPPLGHEL
Position: 470-478
Source molecule (GenBank): I6YAU3.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 18.0

Epitope: Rv2997 (470-478)
Chemical type: Peptide from protein
Sequence: RMPPLGHEL
Position: 470-478
Source molecule (GenBank): I6YAU3.1
Assay category: MhcBinding
Result: Negative

Epitope: Rv2997 (470-478)
Chemical type: Peptide from protein
Sequence: RMPPLGHEL
Position: 470-478
Source molecule (GenBank): I6YAU3.1
Assay category: MhcBinding
Result: Negative

Epitope: Rv1518 (240-248)
Chemical type: Peptide from protein
Sequence: VMATRRNVL
Position: 240-248
Source molecule (GenBank): P9WLV9.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 19.0

Epitope: Rv1518 (240-248)
Chemical type: Peptide from protein
Sequence: VMATRRNVL
Position: 240-248
Source molecule (GenBank): P9WLV9.1
Assay category: MhcBinding
Result: Negative

Epitope: Rv1518 (240-248)
Chemical type: Peptide from protein
Sequence: VMATRRNVL
Position: 240-248
Source molecule (GenBank): P9WLV9.1
Assay category: MhcBinding
Result: Negative

Epitope: Leader HLA-A*03:01/HLA-A*31:01
Chemical type: Peptide from protein
Sequence: VMAPRTLLL
Position: 3-11
Source molecule (GenBank): P16189
Assay category: MhcLigandElution
Result: Positive

Epitope: Leader HLA-C*07:01
Chemical type: Peptide from protein
Sequence: VMAPRALLL
Position: 3-11
Source molecule (GenBank): NP_002108.4
Assay category: MhcLigandElution
Result: Positive