Reference: S M Weenink; J Lo; C R Stephenson; P A McKinney; R Ananieva-Jordanova; B Rees Smith; J Furmaniak; J M Tremble; H J Bodansky; M R Christie. "Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes." Journal of autoimmunity (2009).

Epitope: MAb 96/3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: W799, E836, N858
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive

Epitope: MAb 96/3 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: W799, E836, N858
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive
Host:  0.5-36 years

Epitope: MAb M13 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: L831, H833, V834, E836, Q860
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive
Host:  0.5-36 years

Epitope: MAb M13 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: L831, H833, V834, E836, Q860
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive

Epitope: MAb DS329 epitopic residues
Chemical type: Discontinuous protein residues
Discontinuous residues: W799, L831, H833, V834, Y835, E836, Q860
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive
Host: M 9 years

Epitope: IA-2 (831-850)
Chemical type: Peptide from protein
Sequence: LYHVYEVNLVSEHIWCEDFL
Position: 831-850
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-Low
Host:  mean: 22.8 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (831-850)
Chemical type: Peptide from protein
Sequence: LYHVYEVNLVSEHIWCEDFL
Position: 831-850
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-High
Host:  12-29 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (831-850)
Chemical type: Peptide from protein
Sequence: LYHVYEVNLVSEHIWCEDFL
Position: 831-850
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-High
Host:  12-29 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (831-850)
Chemical type: Peptide from protein
Sequence: LYHVYEVNLVSEHIWCEDFL
Position: 831-850
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-Low
Host:  mean: 22.8 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (841-860)
Chemical type: Peptide from protein
Sequence: SEHIWCEDFLVRSFYLKNVQ
Position: 841-860
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-High
Host:  12-29 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (841-860)
Chemical type: Peptide from protein
Sequence: SEHIWCEDFLVRSFYLKNVQ
Position: 841-860
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-Low
Host:  12-29 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (841-860)
Chemical type: Peptide from protein
Sequence: SEHIWCEDFLVRSFYLKNVQ
Position: 841-860
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-Low
Host:  mean: 22.8 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (841-860)
Chemical type: Peptide from protein
Sequence: SEHIWCEDFLVRSFYLKNVQ
Position: 841-860
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive-Low
Host:  mean: 22.8 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (938-979)
Chemical type: Peptide from protein
Sequence: IAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ
Position: 938-979
Source molecule (GenBank): Q16849.1
Assay category: BCell
Result: Positive
Host:  0.5-36 years