Reference: Laetitia Misson Mindrebo; Hejun Liu; Gabriel Ozorowski; Quoc Tran; Jordan Woehl; Irene Khalek; Jessica M Smith; Shawn Barman; Fangzhu Zhao; Celina Keating; Oliver Limbo; Megan Verma; Jingjia Liu; Robyn L Stanfield; Xueyong Zhu; Hannah L Turner; Devin Sok; Po-Ssu Huang; Dennis R Burton; Andrew B Ward; Ian A Wilson; Joseph G Jardine. "Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins." Proceedings of the National Academy of Sciences of the United States of America (2023).

Epitope: Epitope of CC12.1 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, D405, R408, T415, G416, K417, D420, Y421, Y453, L455, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of CC12.1 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, D405, R408, T415, G416, K417, D420, Y421, Y453, L455, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.72

Epitope: Epitope of CC12.1 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, D405, R408, T415, G416, K417, D420, Y421, Y453, L455, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.83

Epitope: Epitope of CC12.1 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, D405, R408, T415, G416, K417, D420, Y421, Y453, L455, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.21

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 39900.0

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0057

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.72

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 143.0

Epitope: Epitope of Nb-C4-225 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: S375, F377, K378, C379, Y380, V382, S383, P384, T385, P412, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.969

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 911000.0

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.83

Epitope: Epitope of Nb-C4-240 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: L368, Y369, N370, S371, F377, K378, C379, Y380, V382, S383, P384, K386, R408, G413, D427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1060.0

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 99900.0

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.295

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.21

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2950.0

Epitope: Epitope of Nb-C4-255 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, P384, T385, A411, P412, G413, Q414, T415, D427, D428
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 83700.0

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 382.0

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.032

Epitope: Epitope of Nb-C2-136 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, F347, A348, S349, Y351, A352, N354, R355, Y449, N450, L452, R466, I468, T470, E471, I472, N481, G482, V483, E484, F490, L492
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 391.0

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 241000.0

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0944

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nanobody LM18 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S373, F374, S375, T376, K378, G404, D405, V407, R408, V503, G504, Y505, Y508
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive