Reference: R Greenwood; B Wang; K Midkiff; G C White; H-F Lin; J A Frelinger. "Identification of T-cell epitopes in clotting factor IX and lack of tolerance in inbred mice." Journal of thrombosis and haemostasis : JTH (2003).

Epitope: hFIX 19-36
Chemical type: Peptide from protein
Sequence: LLGYLLSAECTVFLDHEN
Position: 19-36
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 25-42
Chemical type: Peptide from protein
Sequence: SAECTVFLDHENANKILN
Position: 25-42
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 37-54
Chemical type: Peptide from protein
Sequence: ANKILNRPKRYNSGKLEE
Position: 37-54
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 43-60
Chemical type: Peptide from protein
Sequence: RPKRYNSGKLEEFVQGNL
Position: 43-60
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 49-66
Chemical type: Peptide from protein
Sequence: SGKLEEFVQGNLERECME
Position: 49-66
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 55-72
Chemical type: Peptide from protein
Sequence: FVQGNLERECMEEKCSFE
Position: 55-72
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 91-108
Chemical type: Peptide from protein
Sequence: YVDGDQCESNPCLNGGSC
Position: 91-108
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 97-114
Chemical type: Peptide from protein
Sequence: CESNPCLNGGSCKDDINS
Position: 97-114
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 103-120
Chemical type: Peptide from protein
Sequence: LNGGSCKDDINSYECWCP
Position: 103-120
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 109-126
Chemical type: Peptide from protein
Sequence: KDDINSYECWCPFGFEGK
Position: 109-126
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 115-132
Chemical type: Peptide from protein
Sequence: YECWCPFGFEGKNCELDV
Position: 115-132
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 121-138
Chemical type: Peptide from protein
Sequence: FGFEGKNCELDVTCNIKN
Position: 121-138
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 127-100
Chemical type: Peptide from protein
Sequence: NCELDVTCNIKNGRCEQF
Position: 127-144
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 133-150
Chemical type: Peptide from protein
Sequence: TCNIKNGRCEQFCKNSAD
Position: 133-150
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 139-156
Chemical type: Peptide from protein
Sequence: GRCEQFCKNSADNKVVCS
Position: 139-156
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 145-162
Chemical type: Peptide from protein
Sequence: CKNSADNKVVCSCTEGYR
Position: 145-162
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 151-168
Chemical type: Peptide from protein
Sequence: NKVVCSCTEGYRLAENQK
Position: 151-168
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 157-174
Chemical type: Peptide from protein
Sequence: CTEGYRLAENQKSCEPAV
Position: 157-174
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 163-180
Chemical type: Peptide from protein
Sequence: LAENQKSCEPAVPFPCGR
Position: 163-180
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 169-186
Chemical type: Peptide from protein
Sequence: SCEPAVPFPCGRVSVSQT
Position: 169-186
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 181-198
Chemical type: Peptide from protein
Sequence: VSVSQTSKLTRAETVFPD
Position: 181-198
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 223-240
Chemical type: Peptide from protein
Sequence: DFTRVVGGEDAKPGQFPW
Position: 223-240
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 229-246
Chemical type: Peptide from protein
Sequence: GGEDAKPGQFPWQVVLNG
Position: 229-246
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 235-252
Chemical type: Peptide from protein
Sequence: PGQFPWQVVLNGKVDAFC
Position: 235-252
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 241-258
Chemical type: Peptide from protein
Sequence: QVVLNGKVDAFCGGSIVN
Position: 241-258
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 247-264
Chemical type: Peptide from protein
Sequence: KVDAFCGGSIVNEKWIVT
Position: 247-264
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 253-270
Chemical type: Peptide from protein
Sequence: GGSIVNEKWIVTAAHCVE
Position: 253-270
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 259-276
Chemical type: Peptide from protein
Sequence: EKWIVTAAHCVETGVKIT
Position: 259-276
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 271-288
Chemical type: Peptide from protein
Sequence: TGVKITVVAGEHNIEETE
Position: 271-288
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 277-294
Chemical type: Peptide from protein
Sequence: VVAGEHNIEETEHTEQKR
Position: 277-294
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 1-18
Chemical type: Peptide from protein
Sequence: MQRVNMIMAESPSLITIC
Position: 1-18
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 7-24
Chemical type: Peptide from protein
Sequence: IMAESPSLITICLLGYLL
Position: 7-24
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 13-30
Chemical type: Peptide from protein
Sequence: SLITICLLGYLLSAECTV
Position: 13-30
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 61-78
Chemical type: Peptide from protein
Sequence: ERECMEEKCSFEEPREVF
Position: 61-78
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 67-84
Chemical type: Peptide from protein
Sequence: EKCSFEEPREVFENTEKT
Position: 67-84
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 73-90
Chemical type: Peptide from protein
Sequence: EAREVFENTEKTTEFWKQ
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 79-96
Chemical type: Peptide from protein
Sequence: ENTEKTTEFWKQYVDGDQ
Position: 79-96
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 187-204
Chemical type: Peptide from protein
Sequence: SKLTRAETVFPDVDYVNP
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 193-210
Chemical type: Peptide from protein
Sequence: ETVFPDVDYVNPTEAETI
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 199-216
Chemical type: Peptide from protein
Sequence: VDYVNPTEAETILDNITQ
Position: 199-216
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 205-222
Chemical type: Peptide from protein
Sequence: TEAETILDNITQGTQSFN
Position: 205-222
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 211-228
Chemical type: Peptide from protein
Sequence: LDNITQGTQSFNDFTRVV
Position: 211-228
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 217-234
Chemical type: Peptide from protein
Sequence: GTQSFNDFTRVVGGEDAK
Position: 217-234
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 283-300
Chemical type: Peptide from protein
Sequence: NIEETEHTEQKRNVIRAI
Position: 283-300
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 289-306
Chemical type: Peptide from protein
Sequence: HTEQKRNVIRAIIPHHNY
Position: 289-306
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 295-312
Chemical type: Peptide from protein
Sequence: NVIRAIIPHHNYNAAINK
Position: 295-312
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 301-318
Chemical type: Peptide from protein
Sequence: IPHHNYNAAINKYNHDIA
Position: 301-318
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 313-330
Chemical type: Peptide from protein
Sequence: YNHDIALLELDEPLVLNS
Position: 313-330
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 325-342
Chemical type: Peptide from protein
Sequence: PLVLNSYVTPICIADKEY
Position: 325-342
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 331-348
Chemical type: Peptide from protein
Sequence: YVTPICIADKEYTNIFLK
Position: 331-348
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 337-354
Chemical type: Peptide from protein
Sequence: IADKEYTNIFLKFGSGYV
Position: 337-354
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 343-360
Chemical type: Peptide from protein
Sequence: TNIFLKFGSGYVSGWARV
Position: 343-360
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 349-366
Chemical type: Peptide from protein
Sequence: FGSGYVSGWARVFHKGRS
Position: 349-366
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 355-372
Chemical type: Peptide from protein
Sequence: SGWARVFHKGRSALVLQY
Position: 355-372
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 361-378
Chemical type: Peptide from protein
Sequence: FHKGRSALVLQYLRVPLV
Position: 361-378
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 379-396
Chemical type: Peptide from protein
Sequence: DRATCLRSTKFTIYNNMF
Position: 379-396
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 391-408
Chemical type: Peptide from protein
Sequence: IYNNMFCAGFHEGGRDSC
Position: 391-408
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 397-414
Chemical type: Peptide from protein
Sequence: CAGFHEGGRDSCQGDSGG
Position: 397-414
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 403-420
Chemical type: Peptide from protein
Sequence: GGRDSCQGDSGGPHVTEV
Position: 403-420
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 409-426
Chemical type: Peptide from protein
Sequence: QGDSGGPHVTEVEGTSFL
Position: 409-426
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 415-432
Chemical type: Peptide from protein
Sequence: PHVTEVEGTSFLTGIISW
Position: 415-432
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 421-438
Chemical type: Peptide from protein
Sequence: EGTSFLTGIISWGEECAM
Position: 421-438
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 427-444
Chemical type: Peptide from protein
Sequence: TGIISWGEECAMKGKYGI
Position: 427-444
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 433-450
Chemical type: Peptide from protein
Sequence: GEECAMKGKYGIYTKVSR
Position: 433-450
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 439-456
Chemical type: Peptide from protein
Sequence: KGKYGIYTKVSRYVNWIK
Position: 439-456
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 445-462
Chemical type: Peptide from protein
Sequence: YTKVSRYVNWIKEKTKLT
Position: 445-462
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Negative
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 268-282
Chemical type: Peptide from protein
Sequence: CVETGVKITVVAGEH
Position: 268-282
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 268-282
Chemical type: Peptide from protein
Sequence: CVETGVKITVVAGEH
Position: 268-282
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 268-282
Chemical type: Peptide from protein
Sequence: CVETGVKITVVAGEH
Position: 268-282
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 319-336
Chemical type: Peptide from protein
Sequence: LLELDEPLVLNSYVTPIC
Position: 319-336
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 319-336
Chemical type: Peptide from protein
Sequence: LLELDEPLVLNSYVTPIC
Position: 319-336
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 319-336
Chemical type: Peptide from protein
Sequence: LLELDEPLVLNSYVTPIC
Position: 319-336
Source molecule (GenBank): AAA98726.1
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: mFIX 263-280
Chemical type: Peptide from protein
Sequence: AAHCLKPGDKIEVVAGEY
Position: 275-292
Source molecule (GenBank): P16294.3
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: hFIX 265-282
Chemical type: Peptide from protein
Sequence: AAHCVETGVKITVVAGEH
Position: 265-282
Source molecule (GenBank): P00740.2
Assay category: TCell
Result: Positive
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo