Reference: Maryline Fresquet; Michael P Lockhart-Cairns; Samuel J Rhoden; Thomas A Jowitt; David C Briggs; Clair Baldock; Paul E Brenchley; Rachel Lennon. "Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch." Proceedings of the National Academy of Sciences of the United States of America (2022).

Epitope: P28mer
Chemical type: Peptide from protein
Sequence: KGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 38-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: P28mer
Chemical type: Peptide from protein
Sequence: KGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 38-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: P28mer
Chemical type: Peptide from protein
Sequence: KGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 38-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00647

Epitope: P28mer
Chemical type: Peptide from protein
Sequence: KGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 38-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: Platform 1
Chemical type: Peptide from protein
Sequence: KGIFVIQSESLKKC
Position: 38-51
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Negative

Epitope: Platform 2
Chemical type: Peptide from protein
Sequence: CIQAGKSVLTLENCK
Position: 51-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Negative

Epitope: Platform 3a
Chemical type: Peptide, no natural source
Sequence: KGIFVICIQAGKSVLTLENCK
Assay category: BCell
Result: Negative

Epitope: Platform 3b
Chemical type: Peptide, no natural source
Sequence: IFVIQSCIQAGKSVLTLENCK
Assay category: BCell
Result: Negative

Epitope: Platform 3c
Chemical type: Peptide, no natural source
Sequence: VIQSESCIQAGKSVLTLENCK
Assay category: BCell
Result: Positive

Epitope: Platform 3d
Chemical type: Peptide, no natural source
Sequence: QSESLKCIQAGKSVLTLENCK
Assay category: BCell
Result: Negative

Epitope: AIP1
Chemical type: Peptide from protein
Sequence: VIQSESLK
Position: 42-49
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0175

Epitope: AIP1
Chemical type: Peptide from protein
Sequence: VIQSESLK
Position: 42-49
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: AIP2
Chemical type: Peptide from protein
Sequence: SVLTLENCK
Position: 57-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0264

Epitope: AIP2
Chemical type: Peptide from protein
Sequence: SVLTLENCK
Position: 57-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: 31mer
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 35-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: 31mer
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 35-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive

Epitope: epitope v1
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGKSVLTLE
Position: 35-62
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive-Low

Epitope: epitope v2
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGKSVL
Position: 35-59
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive-Low

Epitope: epitope v2
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGKSVL
Position: 35-59
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Negative

Epitope: epitope v3
Chemical type: Peptide from protein
Sequence: WQDKGIFVIQSESLKKCIQAGK
Position: 35-56
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Negative

Epitope: epitope v4
Chemical type: Peptide from protein
Sequence: QDKGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 36-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive-Low

Epitope: epitope v5
Chemical type: Peptide from protein
Sequence: DKGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 37-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive-Low

Epitope: epitope v5
Chemical type: Peptide from protein
Sequence: DKGIFVIQSESLKKCIQAGKSVLTLENCK
Position: 37-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Positive-Low

Epitope: Platform 3e
Chemical type: Peptide from protein
Sequence: SESLKKCIQAGKSVLTLENCK
Position: 45-65
Source molecule (GenBank): Q13018.2
Assay category: BCell
Result: Negative