Reference: Karl R Schmitz; Atrish Bagchi; Rob C Roovers; Paul M P van Bergen en Henegouwen; Kathryn M Ferguson. "Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains." Structure (London, England : 1993) (2013).

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.65

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 219.0

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 47.0

Epitope: Epitope of nanobody 7D12 on EGFRd3
Chemical type: Discontinuous protein residues
Discontinuous residues: K346, D347, L349, H370, L372, P373, V374, R377, D379, F381, T382, Q408, H433, S442
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.85

Epitope: Epitope of nanobody EgA1 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, R334, T363, K399, E400, E424, I425, R427, R429, K454, E455, S457, K479, L480, F481, G482, T483, S484
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 276.0

Epitope: Epitope of nanobody EgA1 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, R334, T363, K399, E400, E424, I425, R427, R429, K454, E455, S457, K479, L480, F481, G482, T483, S484
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody EgA1 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, R334, T363, K399, E400, E424, I425, R427, R429, K454, E455, S457, K479, L480, F481, G482, T483, S484
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.05

Epitope: Epitope of nanobody 9G8 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, E317, R334, S364, K399, E400, T402, E424, I425, R427, R429, K454, E455, S457, K478, K479, L480, F481, G482
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody 9G8 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, E317, R334, S364, K399, E400, T402, E424, I425, R427, R429, K454, E455, S457, K478, K479, L480, F481, G482
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.82

Epitope: Epitope of nanobody 9G8 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: Y316, E317, R334, S364, K399, E400, T402, E424, I425, R427, R429, K454, E455, S457, K478, K479, L480, F481, G482
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 166.0

Epitope: Epitope of Fab C225 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C225 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C225 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.82

Epitope: Epitope of Fab C225 on sEGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.05