Reference: C Rizou; J P Ioannidis; E Panou-Pomonis; M Sakarellos-Daitsiotis; C Sakarellos; H M Moutsopoulos; P G Vlachoyiannopoulos. "B-Cell epitope mapping of DNA topoisomerase I defines epitopes strongly associated with pulmonary fibrosis in systemic sclerosis." American journal of respiratory cell and molecular biology (2000).

Epitope: Peptide 1
Chemical type: Peptide from protein
Sequence: MSGDHLHNDSQIEADFRLND
Position: 1-20
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 1
Chemical type: Peptide from protein
Sequence: MSGDHLHNDSQIEADFRLND
Position: 1-20
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 2
Chemical type: Peptide from protein
Sequence: EADFRLNDSHKHKDKHKDRE
Position: 13-32
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 2
Chemical type: Peptide from protein
Sequence: EADFRLNDSHKHKDKHKDRE
Position: 13-32
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 3
Chemical type: Peptide from protein
Sequence: KDKHKDREHRHKEHKKEKDR
Position: 25-44
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 3
Chemical type: Peptide from protein
Sequence: KDKHKDREHRHKEHKKEKDR
Position: 25-44
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 4
Chemical type: Peptide from protein
Sequence: EHKKEKDREKSKHSNSEHKD
Position: 37-56
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 4
Chemical type: Peptide from protein
Sequence: EHKKEKDREKSKHSNSEHKD
Position: 37-56
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 5
Chemical type: Peptide from protein
Sequence: HSNSEHKDSEKKHKEKEKTK
Position: 49-68
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 5
Chemical type: Peptide from protein
Sequence: HSNSEHKDSEKKHKEKEKTK
Position: 49-68
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 6
Chemical type: Peptide from protein
Sequence: HKEKEKTKHKDGSSEKHKDK
Position: 61-80
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 6
Chemical type: Peptide from protein
Sequence: HKEKEKTKHKDGSSEKHKDK
Position: 61-80
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 8
Chemical type: Peptide from protein
Sequence: DKEKRKEEKVRASGDAKIKK
Position: 85-104
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 8
Chemical type: Peptide from protein
Sequence: DKEKRKEEKVRASGDAKIKK
Position: 85-104
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 9
Chemical type: Peptide from protein
Sequence: SGDAKIKKEKENGFSSPPQI
Position: 97-116
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 9
Chemical type: Peptide from protein
Sequence: SGDAKIKKEKENGFSSPPQI
Position: 97-116
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 10
Chemical type: Peptide from protein
Sequence: GFSSPPQIKDEPEDDGYFVP
Position: 109-128
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 10
Chemical type: Peptide from protein
Sequence: GFSSPPQIKDEPEDDGYFVP
Position: 109-128
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 11
Chemical type: Peptide from protein
Sequence: EDDGYFVPPKEDIKPLKRPR
Position: 121-140
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 11
Chemical type: Peptide from protein
Sequence: EDDGYFVPPKEDIKPLKRPR
Position: 121-140
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 12
Chemical type: Peptide from protein
Sequence: IKPLKRPRDEDDADYKPKKI
Position: 133-152
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 12
Chemical type: Peptide from protein
Sequence: IKPLKRPRDEDDADYKPKKI
Position: 133-152
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 13
Chemical type: Peptide from protein
Sequence: ADYKPKKIKTEDTKKEKKRK
Position: 145-164
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 13
Chemical type: Peptide from protein
Sequence: ADYKPKKIKTEDTKKEKKRK
Position: 145-164
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 15
Chemical type: Peptide from protein
Sequence: EDGKLKKPKNKDKDKKVPEP
Position: 169-188
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 15
Chemical type: Peptide from protein
Sequence: EDGKLKKPKNKDKDKKVPEP
Position: 169-188
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 16
Chemical type: Peptide from protein
Sequence: KDKKVPEPDNKKKKPKKEEE
Position: 181-200
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 16
Chemical type: Peptide from protein
Sequence: KDKKVPEPDNKKKKPKKEEE
Position: 181-200
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 17
Chemical type: Peptide from protein
Sequence: KKPKKEEEQKWKWWEEERYP
Position: 193-212
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 17
Chemical type: Peptide from protein
Sequence: KKPKKEEEQKWKWWEEERYP
Position: 193-212
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 18
Chemical type: Peptide from protein
Sequence: WWEEERYPEGIKWKFLEHKG
Position: 205-224
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 18
Chemical type: Peptide from protein
Sequence: WWEEERYPEGIKWKFLEHKG
Position: 205-224
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive

Epitope: Peptide 19
Chemical type: Peptide from protein
Sequence: WKFLEHKGPVFAPPYEPLPE
Position: 217-236
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 19
Chemical type: Peptide from protein
Sequence: WKFLEHKGPVFAPPYEPLPE
Position: 217-236
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive

Epitope: Peptide 20
Chemical type: Peptide from protein
Sequence: PPYEPLPENVKFYYDGKVMK
Position: 229-248
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 20
Chemical type: Peptide from protein
Sequence: PPYEPLPENVKFYYDGKVMK
Position: 229-248
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 22
Chemical type: Peptide from protein
Sequence: AEEVATFFAKMLDHEYTTKE
Position: 253-272
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 22
Chemical type: Peptide from protein
Sequence: AEEVATFFAKMLDHEYTTKE
Position: 253-272
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 24
Chemical type: Peptide from protein
Sequence: NFFKDWRKEMTNEEKNIITN
Position: 277-296
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 24
Chemical type: Peptide from protein
Sequence: NFFKDWRKEMTNEEKNIITN
Position: 277-296
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 25
Chemical type: Peptide from protein
Sequence: EEKNIITNLSKCDFTQMSQY
Position: 289-308
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 25
Chemical type: Peptide from protein
Sequence: EEKNIITNLSKCDFTQMSQY
Position: 289-308
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 27
Chemical type: Peptide from protein
Sequence: TEARKQMSKEEKLKIKEENE
Position: 313-332
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 27
Chemical type: Peptide from protein
Sequence: TEARKQMSKEEKLKIKEENE
Position: 313-332
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 28
Chemical type: Peptide from protein
Sequence: LKIKEENEKLLKEYGFCIMD
Position: 325-344
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 28
Chemical type: Peptide from protein
Sequence: LKIKEENEKLLKEYGFCIMD
Position: 325-344
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 29
Chemical type: Peptide from protein
Sequence: EYGFCIMDNHKERIANFKIE
Position: 337-356
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 29
Chemical type: Peptide from protein
Sequence: EYGFCIMDNHKERIANFKIE
Position: 337-356
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 30
Chemical type: Peptide from protein
Sequence: RIANFKIEPPGLFRGRGNHP
Position: 349-368
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 30
Chemical type: Peptide from protein
Sequence: RIANFKIEPPGLFRGRGNHP
Position: 349-368
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive

Epitope: Peptide 31
Chemical type: Peptide from protein
Sequence: FRGRGNHPKMGMLKRRIMPE
Position: 361-380
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 31
Chemical type: Peptide from protein
Sequence: FRGRGNHPKMGMLKRRIMPE
Position: 361-380
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 32
Chemical type: Peptide from protein
Sequence: LKRRIMPEDIIINCSKDAKV
Position: 373-392
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 32
Chemical type: Peptide from protein
Sequence: LKRRIMPEDIIINCSKDAKV
Position: 373-392
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 35
Chemical type: Peptide from protein
Sequence: KVTWLVSWTENIQGSIKYIM
Position: 409-428
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 35
Chemical type: Peptide from protein
Sequence: KVTWLVSWTENIQGSIKYIM
Position: 409-428
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive

Epitope: Peptide 36
Chemical type: Peptide from protein
Sequence: QGSIKYIMLNPSSRIKGEKD
Position: 421-440
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 36
Chemical type: Peptide from protein
Sequence: QGSIKYIMLNPSSRIKGEKD
Position: 421-440
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 37
Chemical type: Peptide from protein
Sequence: SRIKGEKDWQKYETARRLKK
Position: 433-452
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 37
Chemical type: Peptide from protein
Sequence: SRIKGEKDWQKYETARRLKK
Position: 433-452
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 38
Chemical type: Peptide from protein
Sequence: ETARRLKKCVDKIRNQYRED
Position: 445-464
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive-Low

Epitope: Peptide 38
Chemical type: Peptide from protein
Sequence: ETARRLKKCVDKIRNQYRED
Position: 445-464
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 39
Chemical type: Peptide from protein
Sequence: IRNQYREDWKSKEMKVRQRA
Position: 457-476
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive-Low

Epitope: Peptide 39
Chemical type: Peptide from protein
Sequence: IRNQYREDWKSKEMKVRQRA
Position: 457-476
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 42
Chemical type: Peptide from protein
Sequence: KEEGETADTVGCCSLRVEHI
Position: 493-512
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 42
Chemical type: Peptide from protein
Sequence: KEEGETADTVGCCSLRVEHI
Position: 493-512
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 43
Chemical type: Peptide from protein
Sequence: CSLRVEHINLHPELDGQEYV
Position: 505-524
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 43
Chemical type: Peptide from protein
Sequence: CSLRVEHINLHPELDGQEYV
Position: 505-524
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 44
Chemical type: Peptide from protein
Sequence: ELDGQEYVVEFDFLGKDSIR
Position: 517-536
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive

Epitope: Peptide 44
Chemical type: Peptide from protein
Sequence: ELDGQEYVVEFDFLGKDSIR
Position: 517-536
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 46
Chemical type: Peptide from protein
Sequence: VPVEKRVFKNLQLFMENKQP
Position: 541-560
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 46
Chemical type: Peptide from protein
Sequence: VPVEKRVFKNLQLFMENKQP
Position: 541-560
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 47
Chemical type: Peptide from protein
Sequence: LFMENKQPEDDLFDRLNTGI
Position: 553-572
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 47
Chemical type: Peptide from protein
Sequence: LFMENKQPEDDLFDRLNTGI
Position: 553-572
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 49
Chemical type: Peptide from protein
Sequence: LQDLMEGLTAKVFRTYNASI
Position: 577-596
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 49
Chemical type: Peptide from protein
Sequence: LQDLMEGLTAKVFRTYNASI
Position: 577-596
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 50
Chemical type: Peptide from protein
Sequence: FRTYNASITLQQQLKELTAP
Position: 589-608
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 50
Chemical type: Peptide from protein
Sequence: FRTYNASITLQQQLKELTAP
Position: 589-608
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 53
Chemical type: Peptide from protein
Sequence: AVAILCNHQRAPPKTFEKSM
Position: 625-644
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 53
Chemical type: Peptide from protein
Sequence: AVAILCNHQRAPPKTFEKSM
Position: 625-644
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 54
Chemical type: Peptide from protein
Sequence: PKTFEKSMMNLQTKIDAKKE
Position: 637-656
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 54
Chemical type: Peptide from protein
Sequence: PKTFEKSMMNLQTKIDAKKE
Position: 637-656
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 55
Chemical type: Peptide from protein
Sequence: TKIDAKKEQLADARRDLKSA
Position: 649-668
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 55
Chemical type: Peptide from protein
Sequence: TKIDAKKEQLADARRDLKSA
Position: 649-668
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 56
Chemical type: Peptide from protein
Sequence: ARRDLKSAKADAKVMKDAKT
Position: 661-680
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 56
Chemical type: Peptide from protein
Sequence: ARRDLKSAKADAKVMKDAKT
Position: 661-680
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 57
Chemical type: Peptide from protein
Sequence: KVMKDAKTKKVVESKKKAVQ
Position: 673-692
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 57
Chemical type: Peptide from protein
Sequence: KVMKDAKTKKVVESKKKAVQ
Position: 673-692
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 58
Chemical type: Peptide from protein
Sequence: ESKKKAVQRLEEQLMKLEVQ
Position: 685-704
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 58
Chemical type: Peptide from protein
Sequence: ESKKKAVQRLEEQLMKLEVQ
Position: 685-704
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 59
Chemical type: Peptide from protein
Sequence: QLMKLEVQATDREENKQIAL
Position: 697-716
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 59
Chemical type: Peptide from protein
Sequence: QLMKLEVQATDREENKQIAL
Position: 697-716
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 60
Chemical type: Peptide from protein
Sequence: EENKQIALGTSKLNYLDPRI
Position: 709-728
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 60
Chemical type: Peptide from protein
Sequence: EENKQIALGTSKLNYLDPRI
Position: 709-728
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 61
Chemical type: Peptide from protein
Sequence: LNYLDPRITVAWCKKWGVPI
Position: 721-740
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Positive-Low

Epitope: Peptide 61
Chemical type: Peptide from protein
Sequence: LNYLDPRITVAWCKKWGVPI
Position: 721-740
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 62
Chemical type: Peptide from protein
Sequence: CKKWGVPIEKIYNKTQREKF
Position: 733-752
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 62
Chemical type: Peptide from protein
Sequence: CKKWGVPIEKIYNKTQREKF
Position: 733-752
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 63
Chemical type: Peptide from protein
Sequence: NKTQREKFAWAIDMADEDYE
Position: 745-764
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative

Epitope: Peptide 63
Chemical type: Peptide from protein
Sequence: NKTQREKFAWAIDMADEDYE
Position: 745-764
Source molecule (GenBank): NP_003277.1
Assay category: BCell
Result: Negative