Reference: Paola Redeghieri; Joël Moray; Frédéric Kerff; Sophie Gohy; Teresinha Leal; Serge Muyldermans; Rita Vanbever; Francisco Javier Morales-Yánez; Mireille Dumoulin. "Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties." Protein science : a publication of the Protein Society (2024).

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.5

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2200000.0

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0048

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 60.0

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 270000.0

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.016

Epitope: Epitope of nanobody NbE201 on human neutrophil elastase (hNE)
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R50, F54, H70, C71, A73, N74, V75, P111, V112, N113, L114, L158, I165, F199, F218, V219, R220, G221, G222
Source molecule (GenBank): P08246.1
Assay category: BCell
Result: Positive