Reference: Paul Q Hu; Joost J Oppenheim; Thomas A Medsger; Timothy M Wright. "T cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I." Journal of autoimmunity (2006).

Epitope: topo<sup>476-486</sup>
Chemical type: Peptide from protein
Sequence: RAVALYFIDKLA
Position: 475-486
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>476-486</sup>
Chemical type: Peptide from protein
Sequence: RAVALYFIDKLA
Position: 475-486
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>505-519</sup>
Chemical type: Peptide from protein
Sequence: CSLRVEHINLHPELD
Position: 505-519
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>505-519</sup>
Chemical type: Peptide from protein
Sequence: CSLRVEHINLHPELD
Position: 505-519
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>682-691</sup>
Chemical type: Peptide from protein
Sequence: KVVESKKKAVQRLEE
Position: 682-696
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>682-691</sup>
Chemical type: Peptide from protein
Sequence: KVVESKKKAVQRLEE
Position: 682-696
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>739-750</sup>
Chemical type: Peptide from protein
Sequence: PIEKIYNKTQRE
Position: 739-750
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>739-750</sup>
Chemical type: Peptide from protein
Sequence: PIEKIYNKTQRE
Position: 739-750
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>751-762</sup>
Chemical type: Peptide from protein
Sequence: KFAWAIDMADED
Position: 751-762
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>751-762</sup>
Chemical type: Peptide from protein
Sequence: KFAWAIDMADED
Position: 751-762
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>316-330</sup>
Chemical type: Peptide from protein
Sequence: RKQMSKEEKLKIKEE
Position: 316-330
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>316-330</sup>
Chemical type: Peptide from protein
Sequence: RKQMSKEEKLKIKEE
Position: 316-330
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>424-438</sup>
Chemical type: Peptide from protein
Sequence: IKYIMLNPSSRIKGE
Position: 424-438
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>424-438</sup>
Chemical type: Peptide from protein
Sequence: IKYIMLNPSSRIKGE
Position: 424-438
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>586-600</sup>
Chemical type: Peptide from protein
Sequence: AKVFRTYNASITLQQ
Position: 586-600
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>586-600</sup>
Chemical type: Peptide from protein
Sequence: AKVFRTYNASITLQQ
Position: 586-600
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>661-669</sup>
Chemical type: Peptide from protein
Sequence: KFAWAIDMADEDYEF
Position: 751-765
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: topo<sup>661-669</sup>
Chemical type: Peptide from protein
Sequence: KFAWAIDMADEDYEF
Position: 751-765
Source molecule (GenBank): P11387.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone