Reference: Meghan E Free; Katherine G Stember; Jacob J Hess; Elizabeth A McInnis; Olivier Lardinois; Susan L Hogan; Yichun Hu; Carmen Mendoza; Andrew K Le; Alex J Guseman; Mark A Pilkinton; Dante S Bortone; Kristen Cowens; John Sidney; Edita Karosiene; Bjoern Peters; Eddie James; William W Kwok; Benjamin G Vincent; Simon A Mallal; J Charles Jennette; Dominic J Ciavatta; Ronald J Falk. "Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis." Journal of autoimmunity (2020).

Epitope: Human MPO (435-454)
Chemical type: Peptide from protein
Sequence: PRWDGERLYQEARKIVGAMV
Position: 435-454
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (435-454)
Chemical type: Peptide from protein
Sequence: PRWDGERLYQEARKIVGAMV
Position: 435-454
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (435-454)
Chemical type: Peptide from protein
Sequence: PRWDGERLYQEARKIVGAMV
Position: 435-454
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1050.0

Epitope: Human MPO (435-454)
Chemical type: Peptide from protein
Sequence: PRWDGERLYQEARKIVGAMV
Position: 435-454
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 253.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: BCell
Result: Positive
Host:  46-73 years

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 13900.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 46.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 98.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 74.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 240.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1210.0

Epitope: Human MPO (447-461)
Chemical type: Peptide from protein
Sequence: RKIVGAMVQIITYRD
Position: 447-461
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 615.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 14500.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 433.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 7120.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 6165.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 876.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 321.0

Epitope: Human MPO (105-119)
Chemical type: Peptide from protein
Sequence: PVAATRTAVRAADYL
Position: 105-119
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 285.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 2970.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 2.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 5620.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1345.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 725.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 5.0

Epitope: Human MPO (488-502)
Chemical type: Peptide from protein
Sequence: PRIANVFTNAFRYGH
Position: 488-502
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 1000.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 7050.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 4140.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1090.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 910.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 381.0

Epitope: Human MPO (245-259)
Chemical type: Peptide from protein
Sequence: DQERSLMFMQWGQLL
Position: 245-259
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1180.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 2550.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 32800.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 8.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 12000.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 2475.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 68.0

Epitope: Human MPO (545-559)
Chemical type: Peptide from protein
Sequence: PILRGLMATPAKLNR
Position: 545-559
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 29.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Host:  46-73 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1210.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 11000.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 16.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 409.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 826.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 217.0

Epitope: Human MPO (409-423)
Chemical type: Peptide from protein
Sequence: MPELTSMHTLLLREH
Position: 409-423
Source molecule (GenBank): P05164.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 81.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 56400.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 31100.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 933.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 53700.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 19400.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 9350.0

Epitope: Mouse MPO (413-427)
Chemical type: Peptide from protein
Sequence: GEKLYQEARKIVGAM
Position: 413-427
Source molecule (GenBank): AAH53912.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 1440.0