Reference: Srividhya Swaminathan; Katie E Lineburg; Archana Panikkar; Jyothy Raju; Lawton D Murdolo; Christopher Szeto; Pauline Crooks; Laetitia Le Texier; Sweera Rehan; Michael J Dewar-Oldis; Peter J Barnard; George R Ambalathingal; Michelle A Neller; Kirsty R Short; Stephanie Gras; Rajiv Khanna; Corey Smith. "Ablation of CD8<sup>+</sup> T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3." Nature communications (2022).

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Host:  42-58 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Host:  42-58 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Host:  29-61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Host:  29-61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.3

Epitope: YFP (S 489-497)
Chemical type: Peptide from protein
Sequence: YFPLQSYGF
Position: 489-497
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 61.4

Epitope: YFP-P5R (BA.2)
Chemical type: Peptide from protein
Sequence: YFPLRSYGF
Position: 486-494
Source molecule (GenBank): URA46263.1
Assay category: TCell
Result: Positive-Low
Host:  20-75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP-P5R (BA.2)
Chemical type: Peptide from protein
Sequence: YFPLRSYGF
Position: 486-494
Source molecule (GenBank): URA46263.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 47.6

Epitope: YFP-P8S
Chemical type: Peptide from protein
Sequence: YFPLQSYSF
Position: 489-497
Source molecule (GenBank): UOL34873.1
Assay category: TCell
Result: Positive-Low
Host:  20-75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: YFP-P8S
Chemical type: Peptide from protein
Sequence: YFPLQSYSF
Position: 489-497
Source molecule (GenBank): UOL34873.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 56.9

Epitope: ORF3a 206-215
Chemical type: Peptide from protein
Sequence: YFTSDYYQLY
Position: 206-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Host:  29-61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF3a 201-215
Chemical type: Peptide from protein
Sequence: VVLHSYFTSDYYQLY
Position: 201-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Host:  29-61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF3a 205-219
Chemical type: Peptide from protein
Sequence: SYFTSDYYQLYSTQL
Position: 205-219
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Host:  29-61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S (192-200)
Chemical type: Peptide from protein
Sequence: FVFKNIDGY
Position: 192-200
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (261-269)
Chemical type: Peptide from protein
Sequence: GAAAYYVGY
Position: 261-269
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (444-453)
Chemical type: Peptide from protein
Sequence: KVGGNYNYLY
Position: 444-453
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (865-873)
Chemical type: Peptide from protein
Sequence: LTDEMIAQY
Position: 865-873
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
MHC allele types: 222
Host:  42-58 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (865-873)
Chemical type: Peptide from protein
Sequence: LTDEMIAQY
Position: 865-873
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (30-38)
Chemical type: Peptide from protein
Sequence: NSFTRGVYY
Position: 30-38
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (162-170)
Chemical type: Peptide from protein
Sequence: SANNCTFEY
Position: 162-170
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (162-170)
Chemical type: Peptide from protein
Sequence: SANNCTFEY
Position: 162-170
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
MHC allele types: 222
Host:  42-58 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (1147-1155)
Chemical type: Peptide from protein
Sequence: SFKEELDKY
Position: 1147-1155
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (686-695)
Chemical type: Peptide from protein
Sequence: SVASQSIIAY
Position: 686-695
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S(151-160)
Chemical type: Peptide from protein
Sequence: SWMESEFRVY
Position: 151-160
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (687-695)
Chemical type: Peptide from protein
Sequence: VASQSIIAY
Position: 687-695
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (781-789)
Chemical type: Peptide from protein
Sequence: VFAQVKQIY
Position: 781-789
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (445-453)
Chemical type: Peptide from protein
Sequence: VGGNYNYLY
Position: 445-453
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (1264-1272)
Chemical type: Peptide from protein
Sequence: VLKGVKLHY
Position: 1264-1272
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (1102-1110)
Chemical type: Peptide from protein
Sequence: WFVTQRNFY
Position: 1102-1110
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (258-266)
Chemical type: Peptide from protein
Sequence: WTAGAAAYY
Position: 258-266
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
MHC allele types: 3763
Host:  43 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (680-688)
Chemical type: Peptide from protein
Sequence: SPRRARSVA
Position: 680-688
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Host:  33-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (680-688)
Chemical type: Peptide from protein
Sequence: SPRRARSVA
Position: 680-688
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Omicron BA.1 variant
Chemical type: Peptide from protein
Sequence: SHRRARSVA
Position: 677-685
Source molecule (GenBank): UJU86738.1
Assay category: TCell
Result: Negative
Host:  33-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Omicron BA.1 variant
Chemical type: Peptide from protein
Sequence: SHRRARSVA
Position: 677-685
Source molecule (GenBank): UJU86738.1
Assay category: TCell
Result: Negative
Host:  33-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Delta variant
Chemical type: Peptide from protein
Sequence: SRRRARSVA
Position: 678-686
Source molecule (GenBank): UEO57867.1
Assay category: TCell
Result: Negative
Host:  33-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Delta variant
Chemical type: Peptide from protein
Sequence: SRRRARSVA
Position: 678-686
Source molecule (GenBank): UEO57867.1
Assay category: TCell
Result: Negative
Host:  33-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (269-277)
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Host:  40-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S (269-277)
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Host:  40-55 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated