Reference: Dennis Ungan; Céline Be; Paulina Baczyk; Simon Mittermeier; Sylvie Lehmann; Christian Wiesmann; Thomas Huber; Frank Kolbinger; Jean-Michel Rondeau. "IL-17A complexes with therapeutic antibodies exhibit distinct size distributions, potentially contributing to clinically observed immunogenicity." mAbs (2025).

Epitope: Epitope of CJM112 Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: L76, R78, E80, D81, P82, E83, Y85, P86, S87, V88, W90, R124, P130, F133
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.65

Epitope: Epitope of CJM112 Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: L76, R78, E80, D81, P82, E83, Y85, P86, S87, V88, W90, R124, P130, F133
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of CJM112 Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: L76, R78, E80, D81, P82, E83, Y85, P86, S87, V88, W90, R124, P130, F133
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of secukinumab Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: D65, Y66, Y67, R69, A102, D103
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of secukinumab Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: D65, Y66, Y67, R69, A102, D103
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of secukinumab Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: D65, Y66, Y67, R69, A102, D103
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Ixekizumab Fab on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: K93, C94, R95, H96, L97, G98, V106, D107, Y108, H109, N111, V113, P114, P149, V151, H152
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.92

Epitope: Epitope of Ixekizumab Fab on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: K93, C94, R95, H96, L97, G98, V106, D107, Y108, H109, N111, V113, P114, P149, V151, H152
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Ixekizumab Fab on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: K93, C94, R95, H96, L97, G98, V106, D107, Y108, H109, N111, V113, P114, P149, V151, H152
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of XAB5 Fv on IL-17A
Chemical type: Discontinuous protein residues
Discontinuous residues: L49, R78, E80, D81, P82, Y85, P86, S87, V88, W90, L122, R124, P130, F133
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of Bimekizumab Fab on IL-17A
Chemical type: Region on multi-chain protein
Discontinuous residues: I: R69; J: N75, H77, E91, K93, C94, R95, H96, L97, Y108, N111, S112, V113, P114, Q116, L139, V147, P149, I150, V151, H153
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.66

Epitope: Epitope of Bimekizumab Fab on IL-17A
Chemical type: Region on multi-chain protein
Discontinuous residues: I: R69; J: N75, H77, E91, K93, C94, R95, H96, L97, Y108, N111, S112, V113, P114, Q116, L139, V147, P149, I150, V151, H153
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Bimekizumab Fab on IL-17A
Chemical type: Region on multi-chain protein
Discontinuous residues: I: R69; J: N75, H77, E91, K93, C94, R95, H96, L97, Y108, N111, S112, V113, P114, Q116, L139, V147, P149, I150, V151, H153
Source molecule (GenBank): Q16552.1
Assay category: BCell
Result: Positive