Reference: Amanda M Anderson; Laurie G Landry; Aimon A Alkanani; Laura Pyle; Alvin C Powers; Mark A Atkinson; Clayton E Mathews; Bart O Roep; Aaron W Michels; Maki Nakayama. "Human islet T cells are highly reactive to preproinsulin in type 1 diabetes." Proceedings of the National Academy of Sciences of the United States of America (2021).

Epitope: PPI:2-12
Chemical type: Peptide from protein
Sequence: ALWMRLLPLLA
Position: 2-12
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:2-10
Chemical type: Peptide from protein
Sequence: ALWMRLLPL
Position: 2-10
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:1-11
Chemical type: Peptide from protein
Sequence: MALWMRLLPLL
Position: 1-11
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:1-11
Chemical type: Peptide from protein
Sequence: MALWMRLLPLL
Position: 1-11
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:3-11
Chemical type: Peptide from protein
Sequence: LWMRLLPLL
Position: 3-11
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:3-13
Chemical type: Peptide from protein
Sequence: LWMRLLPLLAL
Position: 3-13
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:15-23
Chemical type: Peptide from protein
Sequence: ALWGPDPAA
Position: 15-23
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:15-24
Chemical type: Peptide from protein
Sequence: ALWGPDPAAA
Position: 15-24
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:15-25
Chemical type: Peptide from protein
Sequence: ALWGPDPAAAF
Position: 15-25
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:31-41
Chemical type: Peptide from protein
Sequence: CGSHLVEALYL
Position: 31-41
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:46-54
Chemical type: Peptide from protein
Sequence: RGFFYTPKT
Position: 46-54
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:47-54
Chemical type: Peptide from protein
Sequence: GFFYTPKT
Position: 47-54
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:69-77
Chemical type: Peptide from protein
Sequence: GGGPGAGSL
Position: 69-77
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:69-79
Chemical type: Peptide from protein
Sequence: GGGPGAGSLQP
Position: 69-79
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:91-99
Chemical type: Peptide from protein
Sequence: IVEQCCTSI
Position: 91-99
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:92-99
Chemical type: Peptide from protein
Sequence: VEQCCTSI
Position: 92-99
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:92-100
Chemical type: Peptide from protein
Sequence: VEQCCTSIC
Position: 92-100
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:96-103
Chemical type: Peptide from protein
Sequence: CTSICSLY
Position: 96-103
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:92-102
Chemical type: Peptide from protein
Sequence: VEQCCTSICSL
Position: 92-102
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: DRiP:1-9
Chemical type: Peptide from protein
Sequence: MLYQHLLPL
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: DRiP:1-9
Chemical type: Peptide from protein
Sequence: MLYQHLLPL
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:45-53
Chemical type: Peptide from protein
Sequence: ERGFFYTPK
Position: 45-53
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell hybridoma
Tissue: blood
Culture conditions: Engineered

Epitope: PPI:1-10
Chemical type: Peptide from protein
Sequence: MALWMRLLPL
Position: 1-10
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:1-10
Chemical type: Peptide from protein
Sequence: MALWMRLLPL
Position: 1-10
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:21-30
Chemical type: Peptide from protein
Sequence: PAAAFVNQHL
Position: 21-30
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:21-30
Chemical type: Peptide from protein
Sequence: PAAAFVNQHL
Position: 21-30
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:31-40
Chemical type: Peptide from protein
Sequence: CGSHLVEALY
Position: 31-40
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:31-40
Chemical type: Peptide from protein
Sequence: CGSHLVEALY
Position: 31-40
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:41-50
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:41-50
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:51-60
Chemical type: Peptide from protein
Sequence: TPKTRREAED
Position: 51-60
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:51-60
Chemical type: Peptide from protein
Sequence: TPKTRREAED
Position: 51-60
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:61-70
Chemical type: Peptide from protein
Sequence: LQVGQVELGG
Position: 61-70
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:61-70
Chemical type: Peptide from protein
Sequence: LQVGQVELGG
Position: 61-70
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:81-90
Chemical type: Peptide from protein
Sequence: ALEGSLQKRG
Position: 81-90
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PPI:81-90
Chemical type: Peptide from protein
Sequence: ALEGSLQKRG
Position: 81-90
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated