Reference: Aparna Shetty; Sheena G Gupta; Michel Varrin-Doyer; Martin S Weber; Thomas Prod'homme; Nicolas Molnarfi; Niannian Ji; Patricia A Nelson; Juan C Patarroyo; Ulf Schulze-Topphoff; Stephen E Fogal; Thomas Forsthuber; Raymond A Sobel; Claude C A Bernard; Anthony J Slavin; Scott S Zamvil. "Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE." Neurology® neuroimmunology & neuroinflammation (2014).

Epitope: MOG (11-30)
Chemical type: Peptide from protein
Sequence: PIRALVGDEAELPCRISPGK
Position: 11-30
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (11-30)
Chemical type: Peptide from protein
Sequence: PIRALVGDEAELPCRISPGK
Position: 11-30
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (21-40)
Chemical type: Peptide from protein
Sequence: ELPCRISPGKNATGMEVGWY
Position: 21-40
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (21-40)
Chemical type: Peptide from protein
Sequence: ELPCRISPGKNATGMEVGWY
Position: 21-40
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (31-50)
Chemical type: Peptide from protein
Sequence: NATGMEVGWYRSPFSRVVHL
Position: 31-50
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (31-50)
Chemical type: Peptide from protein
Sequence: NATGMEVGWYRSPFSRVVHL
Position: 31-50
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (31-50)
Chemical type: Peptide from protein
Sequence: NATGMEVGWYRSPFSRVVHL
Position: 31-50
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (41-60)
Chemical type: Peptide from protein
Sequence: RSPFSRVVHLYRNGKDQDAE
Position: 41-60
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (41-60)
Chemical type: Peptide from protein
Sequence: RSPFSRVVHLYRNGKDQDAE
Position: 41-60
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (51-70)
Chemical type: Peptide from protein
Sequence: YRNGKDQDAEQAPEYRERTE
Position: 51-70
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (51-70)
Chemical type: Peptide from protein
Sequence: YRNGKDQDAEQAPEYRERTE
Position: 51-70
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (61-80)
Chemical type: Peptide from protein
Sequence: QAPEYRERTELLKETISEGK
Position: 61-80
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (61-80)
Chemical type: Peptide from protein
Sequence: QAPEYRERTELLKETISEGK
Position: 61-80
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (71-90)
Chemical type: Peptide from protein
Sequence: LLKETISEGKVTLRIQNVRF
Position: 71-90
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (71-90)
Chemical type: Peptide from protein
Sequence: LLKETISEGKVTLRIQNVRF
Position: 71-90
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (81-100)
Chemical type: Peptide from protein
Sequence: VTLRIQNVRFSDEGGYTCFF
Position: 81-100
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (81-100)
Chemical type: Peptide from protein
Sequence: VTLRIQNVRFSDEGGYTCFF
Position: 81-100
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (101-120)
Chemical type: Peptide from protein
Sequence: RDHSYQEEAAMELKVEDPFY
Position: 101-120
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (101-120)
Chemical type: Peptide from protein
Sequence: RDHSYQEEAAMELKVEDPFY
Position: 101-120
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (111-130)
Chemical type: Peptide from protein
Sequence: MELKVEDPFYWVNPGVLTLI
Position: 111-130
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (111-130)
Chemical type: Peptide from protein
Sequence: MELKVEDPFYWVNPGVLTLI
Position: 111-130
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (111-130)
Chemical type: Peptide from protein
Sequence: MELKVEDPFYWVNPGVLTLI
Position: 111-130
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (121-140)
Chemical type: Peptide from protein
Sequence: WVNPGVLTLIALVPTILLQV
Position: 121-140
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (121-140)
Chemical type: Peptide from protein
Sequence: WVNPGVLTLIALVPTILLQV
Position: 121-140
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (131-150)
Chemical type: Peptide from protein
Sequence: ALVPTILLQVPVGLVFLFLQ
Position: 131-150
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (131-150)
Chemical type: Peptide from protein
Sequence: ALVPTILLQVPVGLVFLFLQ
Position: 131-150
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (151-170)
Chemical type: Peptide from protein
Sequence: HRLRGKLRAEVENLHRTFDP
Position: 151-170
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (151-170)
Chemical type: Peptide from protein
Sequence: HRLRGKLRAEVENLHRTFDP
Position: 151-170
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (161-180)
Chemical type: Peptide from protein
Sequence: VENLHRTFDPHFLRVPCWKI
Position: 161-180
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (161-180)
Chemical type: Peptide from protein
Sequence: VENLHRTFDPHFLRVPCWKI
Position: 161-180
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (171-190)
Chemical type: Peptide from protein
Sequence: HFLRVPCWKITLFVIVPVLG
Position: 171-190
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (171-190)
Chemical type: Peptide from protein
Sequence: HFLRVPCWKITLFVIVPVLG
Position: 171-190
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (181-195)
Chemical type: Peptide from protein
Sequence: TLFVIVPVLGPLVAL
Position: 181-195
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (181-195)
Chemical type: Peptide from protein
Sequence: TLFVIVPVLGPLVAL
Position: 181-195
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (181-195)
Chemical type: Peptide from protein
Sequence: TLFVIVPVLGPLVAL
Position: 181-195
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (181-195)
Chemical type: Peptide from protein
Sequence: TLFVIVPVLGPLVAL
Position: 181-195
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (181-195)
Chemical type: Peptide from protein
Sequence: TLFVIVPVLGPLVAL
Position: 181-195
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (186-200)
Chemical type: Peptide from protein
Sequence: VPVLGPLVALIICYN
Position: 186-200
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (186-200)
Chemical type: Peptide from protein
Sequence: VPVLGPLVALIICYN
Position: 186-200
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (186-200)
Chemical type: Peptide from protein
Sequence: VPVLGPLVALIICYN
Position: 186-200
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (186-200)
Chemical type: Peptide from protein
Sequence: VPVLGPLVALIICYN
Position: 186-200
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-Low
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (186-200)
Chemical type: Peptide from protein
Sequence: VPVLGPLVALIICYN
Position: 186-200
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-Low
Host: F 5-8 weeks

Epitope: MOG (191-210)
Chemical type: Peptide from protein
Sequence: PLVALIICYNWLHRRLAGQF
Position: 191-210
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (191-210)
Chemical type: Peptide from protein
Sequence: PLVALIICYNWLHRRLAGQF
Position: 191-210
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (201-218)
Chemical type: Peptide from protein
Sequence: WLHRRLAGQFLEELRNPF
Position: 201-218
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks

Epitope: MOG (201-218)
Chemical type: Peptide from protein
Sequence: WLHRRLAGQFLEELRNPF
Position: 201-218
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-High
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-Low
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-High
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-Low
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (35-55)
Chemical type: Peptide from protein
Sequence: MEVGWYRSPFSRVVHLYRNGK
Position: 35-55
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (116-130)
Chemical type: Peptide from protein
Sequence: EDPFYWVNPGVLTLI
Position: 116-130
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (111-125)
Chemical type: Peptide from protein
Sequence: MELKVEDPFYWVNPG
Position: 111-125
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Negative
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (119-132)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLTLIAL
Position: 119-132
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (119-132)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLTLIAL
Position: 119-132
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (119-132)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLTLIAL
Position: 119-132
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive-High
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (119-132)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLTLIAL
Position: 119-132
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (119-128)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLT
Position: 119-128
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: MOG (119-128)
Chemical type: Peptide from protein
Sequence: FYWVNPGVLT
Position: 119-128
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: PLP (139-151)
Chemical type: Peptide from protein
Sequence: HCLGKWLGHPDKF
Position: 140-152
Source molecule (GenBank): CAA30184.1
Assay category: TCell
Result: Positive
Host: F 8-12 weeks

Epitope: PLP (139-151)
Chemical type: Peptide from protein
Sequence: HCLGKWLGHPDKF
Position: 140-152
Source molecule (GenBank): CAA30184.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: Ac1–11
Chemical type: Peptide from protein
Sequence: ASQKRPSQRHG
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Ac1–11
Chemical type: Peptide from protein
Sequence: ASQKRPSQRHG
Assay category: TCell
Result: Positive
Host: F 5-8 weeks

Epitope: MOG (118-130)
Chemical type: Peptide from protein
Sequence: PFYWVNPGVLTLI
Position: 118-130
Source molecule (GenBank): AAA03180.1
Assay category: TCell
Result: Positive
Host: F 5-8 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo