Reference: C Franot; D W Roberts; R G Smith; D A Basketter; C Benezra; J P Lepoittevin. "Structure-activity relationships for contact allergenic potential of gamma,gamma-dimethyl-gamma-butyrolactone derivatives. 1. Synthesis and electrophilic reactivity studies of alpha-(omega-substituted-alkyl)-gamma,gamma-dimethyl-gamma-butyrolacton es and correlation of skin sensitization potential and cross-sensitization patterns with structure." Chemical research in toxicology (1994).

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]methyl]dihydro-2(3H)-furanone (lh)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-High

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(Bromomethyl)-5,5-dimethyldihydro-2(3H)-furanone (lb)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]methyl]-5,5-dimethyldihydro-2(3H)-furanone (lg)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-High

Epitope: 5,5-Dimethyl-3-(thiocyanatomethyl)dihydro-2(3H)-furanone (li)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate

Epitope: 3-[(Mesyloxy)methyl]-5,5-dimethyldihydro-2(3H)-furanone (1c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[[ [ (Phenylsulfonyl)oxy]methyl]-5,5-dimethyldihydro-2(3H)-furanone (1f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-[(tosy1oxy)methylldihydro-2(3H)-furanone (ld)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[[ [ (4-Methoxyphenyl)sulfonyl]oxy]methyl]-5,5-dimethyldihydro-2(3H)-furanone (le)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate

Epitope: 3-(Chloromethyl)-5,5-dimethyldihydro-2(3H)-furanone (la)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate

Epitope: 5,5-Dimethyl-3-methylenedihydro-2(3H)-furanone (1l)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-High

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[ [ [ (4-nitrophenyl)sulfonyl]oxy]ethyl]-dihydro-2(3H)-furanone (2h)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Chlorophenyl)sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2g)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(2-Bromoethyl)-5,5-dimethyldihydro-2 (3H)-furanone (2b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[[(Methylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2c)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ (Phenylsulfonyl)oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2f)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-[(tosyloxy)ethyl]dihydro-2(3H)-furanone (2d)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-[ [ [ (4-Methoxyphenyl) sulfonyl]oxy]ethyl]-5,5-dimethyldihydro-2(3H)-furanone (2e)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 5,5-Dimethyl-3-(thiocyanatoethyl)dihydro-2(3H)-furanone (2i)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(3'-Bromopropy1)-5,5'-dimethyldihydro-2(3H)-furanone (3b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(3'-Bromopropy1)-5,5'-dimethyldihydro-2(3H)-furanone (3b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Low

Epitope: 3-(3'-Bromopropy1)-5,5'-dimethyldihydro-2(3H)-furanone (3b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Negative

Epitope: 3-(3'-Bromopropy1)-5,5'-dimethyldihydro-2(3H)-furanone (3b)
Chemical type: Other Non-Sequence
Assay category: TCell
Result: Positive-Intermediate