Reference: Hidefumi Inaba; Shuhei Morita; Daisuke Kosugi; Yuki Asai; Yosuke Kaido; Saya Ito; Tomonao Hirobata; Gen Inoue; Yuki Yamamoto; Masatoshi Jinnin; Hiroaki Kimura; Masao Ota; Yuko Okudaira; Hiroyasu Nakatani; Tomoko Kobayashi; Shintaro Iwama; Hiroshi Arima; Takaaki Matsuoka. "Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors." Frontiers in immunology (2023).

Epitope: proinsulin 1-15
Chemical type: Peptide from protein
Sequence: MALWMRLLPLLALLA
Position: 1-15
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 1-15
Chemical type: Peptide from protein
Sequence: MALWMRLLPLLALLA
Position: 1-15
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 7-21
Chemical type: Peptide from protein
Sequence: LLPLLALLALWGPDP
Position: 7-21
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 7-21
Chemical type: Peptide from protein
Sequence: LLPLLALLALWGPDP
Position: 7-21
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 13-27
Chemical type: Peptide from protein
Sequence: LLALWGPDPAAAFVN
Position: 13-27
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 13-27
Chemical type: Peptide from protein
Sequence: LLALWGPDPAAAFVN
Position: 13-27
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 19-33
Chemical type: Peptide from protein
Sequence: PDPAAAFVNQHLCGS
Position: 19-33
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 19-33
Chemical type: Peptide from protein
Sequence: PDPAAAFVNQHLCGS
Position: 19-33
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 25-39
Chemical type: Peptide from protein
Sequence: FVNQHLCGSHLVEAL
Position: 25-39
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 25-39
Chemical type: Peptide from protein
Sequence: FVNQHLCGSHLVEAL
Position: 25-39
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 29-43
Chemical type: Peptide from protein
Sequence: HLCGSHLVEALYLVC
Position: 29-43
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 29-43
Chemical type: Peptide from protein
Sequence: HLCGSHLVEALYLVC
Position: 29-43
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 33-47
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 33-47
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 37-51
Chemical type: Peptide from protein
Sequence: EALYLVCGERGFFYT
Position: 37-51
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 37-51
Chemical type: Peptide from protein
Sequence: EALYLVCGERGFFYT
Position: 37-51
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 42-56
Chemical type: Peptide from protein
Sequence: VCGERGFFYTPKTRR
Position: 42-56
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 42-56
Chemical type: Peptide from protein
Sequence: VCGERGFFYTPKTRR
Position: 42-56
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 43-57
Chemical type: Peptide from protein
Sequence: CGERGFFYTPKTRRE
Position: 43-57
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 43-57
Chemical type: Peptide from protein
Sequence: CGERGFFYTPKTRRE
Position: 43-57
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 44-58
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 44-58
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 45-59
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTRREAE
Position: 45-59
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 45-59
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTRREAE
Position: 45-59
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 46-60
Chemical type: Peptide from protein
Sequence: RGFFYTPKTRREAED
Position: 46-60
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 46-60
Chemical type: Peptide from protein
Sequence: RGFFYTPKTRREAED
Position: 46-60
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 47-61
Chemical type: Peptide from protein
Sequence: GFFYTPKTRREAEDL
Position: 47-61
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 47-61
Chemical type: Peptide from protein
Sequence: GFFYTPKTRREAEDL
Position: 47-61
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 48-62
Chemical type: Peptide from protein
Sequence: FFYTPKTRREAEDLQ
Position: 48-62
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 48-62
Chemical type: Peptide from protein
Sequence: FFYTPKTRREAEDLQ
Position: 48-62
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 49-63
Chemical type: Peptide from protein
Sequence: FYTPKTRREAEDLQV
Position: 49-63
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 49-63
Chemical type: Peptide from protein
Sequence: FYTPKTRREAEDLQV
Position: 49-63
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 50-64
Chemical type: Peptide from protein
Sequence: YTPKTRREAEDLQVG
Position: 50-64
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 50-64
Chemical type: Peptide from protein
Sequence: YTPKTRREAEDLQVG
Position: 50-64
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 51-65
Chemical type: Peptide from protein
Sequence: TPKTRREAEDLQVGQ
Position: 51-65
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 51-65
Chemical type: Peptide from protein
Sequence: TPKTRREAEDLQVGQ
Position: 51-65
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 52-66
Chemical type: Peptide from protein
Sequence: PKTRREAEDLQVGQV
Position: 52-66
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 52-66
Chemical type: Peptide from protein
Sequence: PKTRREAEDLQVGQV
Position: 52-66
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 53-67
Chemical type: Peptide from protein
Sequence: KTRREAEDLQVGQVE
Position: 53-67
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 53-67
Chemical type: Peptide from protein
Sequence: KTRREAEDLQVGQVE
Position: 53-67
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 54-68
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVEL
Position: 54-68
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 54-68
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVEL
Position: 54-68
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 59-73
Chemical type: Peptide from protein
Sequence: EDLQVGQVELGGGPG
Position: 59-73
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 59-73
Chemical type: Peptide from protein
Sequence: EDLQVGQVELGGGPG
Position: 59-73
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 64-78
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 64-78
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 69-83
Chemical type: Peptide from protein
Sequence: GGGPGAGSLQPLALE
Position: 69-83
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 69-83
Chemical type: Peptide from protein
Sequence: GGGPGAGSLQPLALE
Position: 69-83
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 74-88
Chemical type: Peptide from protein
Sequence: AGSLQPLALEGSLQK
Position: 74-88
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 74-88
Chemical type: Peptide from protein
Sequence: AGSLQPLALEGSLQK
Position: 74-88
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 75-89
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSLQKR
Position: 75-89
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 75-89
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSLQKR
Position: 75-89
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 77-91
Chemical type: Peptide from protein
Sequence: LQPLALEGSLQKRGI
Position: 77-91
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 77-91
Chemical type: Peptide from protein
Sequence: LQPLALEGSLQKRGI
Position: 77-91
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 78-92
Chemical type: Peptide from protein
Sequence: QPLALEGSLQKRGIV
Position: 78-92
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 78-92
Chemical type: Peptide from protein
Sequence: QPLALEGSLQKRGIV
Position: 78-92
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 79-93
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 79-93
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 84-98
Chemical type: Peptide from protein
Sequence: GSLQKRGIVEQCCTS
Position: 84-98
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 84-98
Chemical type: Peptide from protein
Sequence: GSLQKRGIVEQCCTS
Position: 84-98
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 88-102
Chemical type: Peptide from protein
Sequence: KRGIVEQCCTSICSL
Position: 88-102
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 88-102
Chemical type: Peptide from protein
Sequence: KRGIVEQCCTSICSL
Position: 88-102
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 92-106
Chemical type: Peptide from protein
Sequence: VEQCCTSICSLYQLE
Position: 92-106
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: proinsulin 92-106
Chemical type: Peptide from protein
Sequence: VEQCCTSICSLYQLE
Position: 92-106
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: proinsulin 96-110
Chemical type: Peptide from protein
Sequence: CTSICSLYQLENYCN
Position: 96-110
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High

Epitope: proinsulin 96-110
Chemical type: Peptide from protein
Sequence: CTSICSLYQLENYCN
Position: 96-110
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low