Reference: M Soliman; E Kaplan; V Guimaraes; T Yanagawa; L J DeGroot. "T-cell recognition of residue 158-176 in thyrotropin receptor confers risk for development of thyroid autoimmunity in siblings in a family with Graves' disease." Thyroid : official journal of the American Thyroid Association (1996).

Epitope: hTSH-R (20-35)
Chemical type: Peptide from protein
Sequence: GGMGCSSPPCECHQEE
Position: 20-35
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (30-49)
Chemical type: Peptide from protein
Sequence: ECHQEEDFRVTCKDIQRIPS
Position: 30-49
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (44-62)
Chemical type: Peptide from protein
Sequence: IQRIPSLPPSTQTLKLIET
Position: 44-62
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (57-75)
Chemical type: Peptide from protein
Sequence: LKLIETHLRTIPSHAFSNL
Position: 57-75
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (70-88)
Chemical type: Peptide from protein
Sequence: HAFSNLPNISRIYVSIDVT
Position: 70-88
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (83-102)
Chemical type: Peptide from protein
Sequence: VSIDVTLQQLESHSFYNLSK
Position: 83-102
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (97-112)
Chemical type: Peptide from protein
Sequence: FYNLSKVTHIEIRNTR
Position: 97-112
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (109-124)
Chemical type: Peptide from protein
Sequence: RNTRNLTYIDPDALKE
Position: 109-124
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (132-150)
Chemical type: Peptide from protein
Sequence: GIFNTGLKMFPDLTKVYST
Position: 132-150
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (145-163)
Chemical type: Peptide from protein
Sequence: TKVYSTDIFFILEITDNPY
Position: 145-163
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (158-176)
Chemical type: Peptide from protein
Sequence: ITDNPYMTSIPVNAFQGLC
Position: 158-176
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  31-62 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (158-176)
Chemical type: Peptide from protein
Sequence: ITDNPYMTSIPVNAFQGLC
Position: 158-176
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (172-186)
Chemical type: Peptide from protein
Sequence: FQGLCNETLTLKLYN
Position: 172-186
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (183-198)
Chemical type: Peptide from protein
Sequence: KLYNNGFTSVQGYAFN
Position: 183-198
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (195-210)
Chemical type: Peptide from protein
Sequence: YAFNGTKLDAVYLNKN
Position: 195-210
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (217-232)
Chemical type: Peptide from protein
Sequence: DKDAFGGVYSGPSLLD
Position: 217-232
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (227-242)
Chemical type: Peptide from protein
Sequence: GPSLLDVSQTSVTALP
Position: 227-242
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (237-252)
Chemical type: Peptide from protein
Sequence: SVTALPSKGLEHLKEL
Position: 237-252
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (248-263)
Chemical type: Peptide from protein
Sequence: HLKELIARNTWTLKKL
Position: 248-263
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (258-277)
Chemical type: Peptide from protein
Sequence: WTLKKLPLSLSFLHLTRADL
Position: 258-277
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (286-305)
Chemical type: Peptide from protein
Sequence: FKNQKKIRGILESLMCNESS
Position: 286-305
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (301-320)
Chemical type: Peptide from protein
Sequence: CNESSMQSLRQRKSVNALNS
Position: 301-320
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (315-334)
Chemical type: Peptide from protein
Sequence: VNALNSPLHQEYEENLGDSI
Position: 315-334
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (329-348)
Chemical type: Peptide from protein
Sequence: NLGDSIVGYKEKSKFQDTHN
Position: 329-348
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (343-362)
Chemical type: Peptide from protein
Sequence: FQDTHNNAHYYVFFEEQEDE
Position: 343-362
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (357-376)
Chemical type: Peptide from protein
Sequence: EEQEDEIIGFGQELKNPQEE
Position: 357-376
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (371-390)
Chemical type: Peptide from protein
Sequence: KNPQEETLQAFDSHYDYTIC
Position: 371-390
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (385-404)
Chemical type: Peptide from protein
Sequence: YDYTICGDSEDMVCTPKSDE
Position: 385-404
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: hTSH-R (399-418)
Chemical type: Peptide from protein
Sequence: TPKSDEFNPCEDIMGYKFLR
Position: 399-418
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Negative
Host:  2 to 62
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo