Reference: Yuxiang Luo; Banghui Liu; Ruijie Liu; Qiuluan Chen; Xiaoli Xiong; Huilin Li. "Hydrogen-Deuterium Exchange Mass Spectrometry Reveals an Antibody-Induced Allosteric Pathway Driving SARS-CoV-2 Spike Trimer Disassembly." Journal of the American Chemical Society (2026).

Epitope: Epitope of mAb R1-32 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, W353, N354, R355, K356, R357, Y396, Y449, N450, L452, R457, K462, P463, F464, E465, R466, D467, I468, S469, T470, E471, I472, G482, F490, L492, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb R1-32 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, W353, N354, R355, K356, R357, Y396, Y449, N450, L452, R457, K462, P463, F464, E465, R466, D467, I468, S469, T470, E471, I472, G482, F490, L492, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb R1-32 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, W353, N354, R355, K356, R357, Y396, Y449, N450, L452, R457, K462, P463, F464, E465, R466, D467, I468, S469, T470, E471, I472, G482, F490, L492, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.82

Epitope: Epitope of mAb R1-32 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, W353, N354, R355, K356, R357, Y396, Y449, N450, L452, R457, K462, P463, F464, E465, R466, D467, I468, S469, T470, E471, I472, G482, F490, L492, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 46700.0

Epitope: Epitope of mAb R1-32 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, W353, N354, R355, K356, R357, Y396, Y449, N450, L452, R457, K462, P463, F464, E465, R466, D467, I468, S469, T470, E471, I472, G482, F490, L492, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000225

Epitope: Epitope of mAb B38 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, Q409, T415, G416, K417, D420, Y421, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, F490, Q493,Y495, G496, Q498, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb B38 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, Q409, T415, G416, K417, D420, Y421, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, F490, Q493,Y495, G496, Q498, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 115.0

Epitope: Epitope of mAb B38 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, Q409, T415, G416, K417, D420, Y421, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, F490, Q493,Y495, G496, Q498, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2510.0

Epitope: Epitope of mAb B38 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, Q409, T415, G416, K417, D420, Y421, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, F490, Q493,Y495, G496, Q498, N501, G502, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000288