Reference: Eystein S Husebye; Eirik Bratland; Geir Bredholt; Mati Fridkin; Molly Dayan; Edna Mozes. "The substrate-binding domain of 21-hydroxylase, the main autoantigen in autoimmune Addison's disease, is an immunodominant T cell epitope." Endocrinology (2006).

Epitope: 21OH (43-61)
Chemical type: Peptide from protein
Sequence: DLPIYLLGLTQKFGPIYRL
Position: 44-62
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (43-61)
Chemical type: Peptide from protein
Sequence: DLPIYLLGLTQKFGPIYRL
Position: 44-62
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (73-81)
Chemical type: Peptide from protein
Sequence: SKRTIEEAM
Position: 74-82
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (73-81)
Chemical type: Peptide from protein
Sequence: SKRTIEEAM
Position: 74-82
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (119-127)
Chemical type: Peptide from protein
Sequence: HKKLTRSAL
Position: 120-128
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (119-127)
Chemical type: Peptide from protein
Sequence: HKKLTRSAL
Position: 120-128
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (160-184)
Chemical type: Peptide, no natural source
Sequence: IEEEFSLLTVSIIVYLTFGDKIKDD
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (160-184)
Chemical type: Peptide, no natural source
Sequence: IEEEFSLLTVSIIVYLTFGDKIKDD
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (191-202)
Chemical type: Peptide, no natural source
Sequence: YKVIQEVLKTWS
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (191-202)
Chemical type: Peptide, no natural source
Sequence: YKVIQEVLKTWS
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (191-202)
Chemical type: Peptide, no natural source
Sequence: YKVIQEVLKTWS
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (223-231)
Chemical type: Peptide from protein
Sequence: LRRLKQAIE
Position: 224-232
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (223-231)
Chemical type: Peptide from protein
Sequence: LRRLKQAIE
Position: 224-232
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (253-266)
Chemical type: Peptide from protein
Sequence: WRDMMDYMLQGVAQ
Position: 254-267
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (253-266)
Chemical type: Peptide from protein
Sequence: WRDMMDYMLQGVAQ
Position: 254-267
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (278-286)
Chemical type: Peptide from protein
Sequence: EGHVHMAAV
Position: 279-287
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (278-286)
Chemical type: Peptide from protein
Sequence: EGHVHMAAV
Position: 279-287
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-350)
Chemical type: Peptide from protein
Sequence: LPLLNATIA
Position: 343-351
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-350)
Chemical type: Peptide from protein
Sequence: LPLLNATIA
Position: 343-351
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-357)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRP
Position: 343-358
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-357)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRP
Position: 343-358
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-357)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRP
Position: 343-358
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive-Low
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (342-361)
Chemical type: Peptide from protein
Sequence: LPLLNATIAEVLRLRPVVPL
Position: 343-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive-High
Host: F 8-12 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (346-357)
Chemical type: Peptide from protein
Sequence: NATIAEVLRLRP
Position: 347-358
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (346-357)
Chemical type: Peptide from protein
Sequence: NATIAEVLRLRP
Position: 347-358
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (346-361)
Chemical type: Peptide from protein
Sequence: NATIAEVLRLRPVVPL
Position: 347-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (346-361)
Chemical type: Peptide from protein
Sequence: NATIAEVLRLRPVVPL
Position: 347-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (346-361)
Chemical type: Peptide from protein
Sequence: NATIAEVLRLRPVVPL
Position: 347-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (353-361)
Chemical type: Peptide from protein
Sequence: LRLRPVVPL
Position: 354-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (353-361)
Chemical type: Peptide from protein
Sequence: LRLRPVVPL
Position: 354-362
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (376-384)
Chemical type: Peptide from protein
Sequence: YDIPEGTVI
Position: 377-385
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (376-384)
Chemical type: Peptide from protein
Sequence: YDIPEGTVI
Position: 377-385
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (376-393)
Chemical type: Peptide from protein
Sequence: YDIPEGTVIIPNLQGAHL
Position: 377-394
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (376-393)
Chemical type: Peptide from protein
Sequence: YDIPEGTVIIPNLQGAHL
Position: 377-394
Source molecule (GenBank): NP_000491.2
Assay category: TCell
Result: Positive
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (437-453)
Chemical type: Peptide from protein
Sequence: DLFVVLTRLLQAFTLLP
Position: 437-453
Source molecule (GenBank): AAB59440.1
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: 21OH (437-453)
Chemical type: Peptide from protein
Sequence: DLFVVLTRLLQAFTLLP
Position: 437-453
Source molecule (GenBank): AAB59440.1
Assay category: TCell
Result: Negative
Host: F 8-12 weeks
Cell type: lymph node cells
Tissue: lymph node
Culture conditions: Direct Ex Vivo