Reference: Swetha Raman; Melissa Beilschmidt; Minh To; Kevin Lin; Francine Lui; Yazen Jmeian; Mark Ng; Minerva Fernandez; Ying Fu; Keith Mascall; Alejandro Duque; Xiaowei Wang; Guohua Pan; Stephane Angers; Jason Moffat; Sachdev S Sidhu; Jeanne Magram; Angus M Sinclair; Johan Fransson; Jean-Philippe Julien. "Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies." Proceedings of the National Academy of Sciences of the United States of America (2019).

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.1

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Negative

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 690000.0

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 5.2

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1150000.0

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00597

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1230000.0

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 40.8

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0283

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.5

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00185

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.59

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.25

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.4

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.3

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.3

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.2

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.2

Epitope: Epitope of F7.B Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: L81, H84, Q85, Y87, P88, L89, K91, L134, K137, F138, G139, F140, Q141
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 56.6

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.01547

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.5

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.5

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 400000.0

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0018

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 270000.0

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.3

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.5

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.8

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.5

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.82

Epitope: Epitope of F6 Fab on FZD7
Chemical type: Discontinuous protein residues
Discontinuous residues: I54, P55, L56, H73, E77, D78, G80, L81, E82, V83, H84, Q85, F86, Y87, P88, L89, K91, M135, F138, G139, F140, Q141, R145
Source molecule (GenBank): O75084.2
Assay category: BCell
Result: Positive