Reference: Anish Suri; James J Walters; Henry W Rohrs; Michael L Gross; Emil R Unanue. "First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules." Journal of immunology (Baltimore, Md. : 1950) (2008).

Epitope: Synaptotagmin 11 (177-189)
Chemical type: Peptide from protein
Sequence: IQEAHGLPVMDDQ
Position: 177-189
Source molecule (GenBank): NP_061274.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Synaptotagmin 11 (177-189)
Chemical type: Peptide from protein
Sequence: IQEAHGLPVMDDQ
Position: 177-189
Source molecule (GenBank): NP_061274.2
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 400.0

Epitope: Synaptotagmin 11 (177-191)
Chemical type: Peptide from protein
Sequence: IQEAHGLPVMDDQTQ
Position: 177-191
Source molecule (GenBank): NP_061274.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Synaptotagmin 11 (174-191)
Chemical type: Peptide from protein
Sequence: VVTIQEAHGLPVMDDQTQ
Position: 174-191
Source molecule (GenBank): NP_061274.2
Assay category: MhcLigandElution
Result: Positive

Epitope: ODZ (837-849)
Chemical type: Peptide from protein
Sequence: TPSQQAAKSFYDR
Position: 837-849
Source molecule (GenBank): Q9WTS6.1
Assay category: MhcLigandElution
Result: Positive

Epitope: ODZ (837-849)
Chemical type: Peptide from protein
Sequence: TPSQQAAKSFYDR
Position: 837-849
Source molecule (GenBank): Q9WTS6.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 1400.0

Epitope: ODZ (836-849)
Chemical type: Peptide from protein
Sequence: QTPSQQAAKSFYDR
Position: 836-849
Source molecule (GenBank): Q9WTS6.1
Assay category: MhcLigandElution
Result: Positive

Epitope: ODZ (835-849)
Chemical type: Peptide from protein
Sequence: LQTPSQQAAKSFYDR
Position: 835-849
Source molecule (GenBank): Q9WTS6.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Neuromodulin (184-201)
Chemical type: Peptide from protein
Sequence: QPPTETAESSQAEEEKDA
Position: 184-201
Source molecule (GenBank): NP_032109.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Neuromodulin (184-201)
Chemical type: Peptide from protein
Sequence: QPPTETAESSQAEEEKDA
Position: 184-201
Source molecule (GenBank): NP_032109.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 500.0

Epitope: SynAp (262-279)
Chemical type: Peptide from protein
Sequence: TPPVVIKSQLKSQEDEEE
Position: 262-279
Source molecule (GenBank): NP_080208.2
Assay category: TCell
Result: Positive
Host:  10-14 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: SynAp (262-279)
Chemical type: Peptide from protein
Sequence: TPPVVIKSQLKSQEDEEE
Position: 262-279
Source molecule (GenBank): NP_080208.2
Assay category: MhcLigandElution
Result: Positive

Epitope: SynAp (262-279)
Chemical type: Peptide from protein
Sequence: TPPVVIKSQLKSQEDEEE
Position: 262-279
Source molecule (GenBank): NP_080208.2
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 300.0

Epitope: NCAM-180 (189-203)
Chemical type: Peptide from protein
Sequence: SAPKVAPLVDLSDT
Position: 189-202
Source molecule (GenBank): CAA33151.1
Assay category: MhcLigandElution
Result: Positive

Epitope: NCAM-180 (189-203)
Chemical type: Peptide from protein
Sequence: SAPKVAPLVDLSDT
Position: 189-202
Source molecule (GenBank): CAA33151.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 600.0

Epitope: Axonal transporter (885-898)
Chemical type: Peptide from protein
Sequence: VAVQAISADEEAPD
Position: 885-898
Source molecule (GenBank): P33173.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Axonal transporter (885-898)
Chemical type: Peptide from protein
Sequence: VAVQAISADEEAPD
Position: 885-898
Source molecule (GenBank): P33173.2
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 200.0

Epitope: BACE (112-122)
Chemical type: Peptide from protein
Sequence: FAVAGAPHSYIDT
Position: 112-124
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (112-122)
Chemical type: Peptide from protein
Sequence: FAVAGAPHSYIDT
Position: 112-124
Source molecule (GenBank): Q9JL18.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 900.0

Epitope: BACE (113-126)
Chemical type: Peptide from protein
Sequence: AVAGAPHSYIDTYF
Position: 113-126
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (112-125)
Chemical type: Peptide from protein
Sequence: FAVAGAPHSYIDTY
Position: 112-125
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (112-126)
Chemical type: Peptide from protein
Sequence: FAVAGAPHSYIDTYF
Position: 112-126
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (112-127)
Chemical type: Peptide from protein
Sequence: FAVAGAPHSYIDTYFD
Position: 112-127
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (109-125)
Chemical type: Peptide from protein
Sequence: SSNFAVAGAPHSYIDTY
Position: 109-125
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: BACE (109-126)
Chemical type: Peptide from protein
Sequence: SSNFAVAGAPHSYIDTYF
Position: 109-126
Source molecule (GenBank): Q9JL18.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Synapse cell adhesion molecule (204-218)
Chemical type: Peptide from protein
Sequence: VTSQLMLKVHKEDDG
Position: 204-218
Source molecule (GenBank): NP_001020771.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Synapse cell adhesion molecule (204-218)
Chemical type: Peptide from protein
Sequence: VTSQLMLKVHKEDDG
Position: 204-218
Source molecule (GenBank): NP_001020771.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 1000.0

Epitope: Synapse cell adhesion molecule (203-218)
Chemical type: Peptide from protein
Sequence: TVTSQLMLKVHKEDDG
Position: 203-218
Source molecule (GenBank): NP_001020771.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Secretogranin II (234-248)
Chemical type: Peptide from protein
Sequence: DVYKTNNIAYEDVVG
Position: 234-248
Source molecule (GenBank): AAH48249.1
Assay category: TCell
Result: Positive
Host: M 8-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: Secretogranin II (234-248)
Chemical type: Peptide from protein
Sequence: DVYKTNNIAYEDVVG
Position: 234-248
Source molecule (GenBank): AAH48249.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Secretogranin II (234-248)
Chemical type: Peptide from protein
Sequence: DVYKTNNIAYEDVVG
Position: 234-248
Source molecule (GenBank): AAH48249.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 500.0

Epitope: Secretogranin II (420-434)
Chemical type: Peptide from protein
Sequence: APGRGMVEALPDGLS
Position: 380-394
Source molecule (GenBank): AAH48249.1
Assay category: TCell
Result: Negative
Host: M 8-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: Secretogranin II (420-434)
Chemical type: Peptide from protein
Sequence: APGRGMVEALPDGLS
Position: 380-394
Source molecule (GenBank): AAH48249.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Secretogranin II (420-434)
Chemical type: Peptide from protein
Sequence: APGRGMVEALPDGLS
Position: 380-394
Source molecule (GenBank): AAH48249.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 1800.0

Epitope: Chromogranin A (407-423)
Chemical type: Peptide from protein
Sequence: RPSSREDSVEARSDFEE
Position: 407-423
Source molecule (GenBank): P26339.1
Assay category: TCell
Result: Positive
Host: M 8-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: Chromogranin A (407-423)
Chemical type: Peptide from protein
Sequence: RPSSREDSVEARSDFEE
Position: 407-423
Source molecule (GenBank): P26339.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Chromogranin A (407-423)
Chemical type: Peptide from protein
Sequence: RPSSREDSVEARSDFEE
Position: 407-423
Source molecule (GenBank): P26339.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 400.0

Epitope: NMDA 2A (36-46)
Chemical type: Peptide from protein
Sequence: IAVLLGHSHDV
Position: 36-46
Source molecule (GenBank): NP_032196.2
Assay category: MhcLigandElution
Result: Positive

Epitope: NMDA 2A (36-46)
Chemical type: Peptide from protein
Sequence: IAVLLGHSHDV
Position: 36-46
Source molecule (GenBank): NP_032196.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 30000.0

Epitope: Gabarap (29-45)
Chemical type: Peptide from protein
Sequence: VPVIVEKAPKARIGDLD
Position: 29-45
Source molecule (GenBank): NP_062723.1
Assay category: TCell
Result: Positive
Host: M 8-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: Gabarap (29-45)
Chemical type: Peptide from protein
Sequence: VPVIVEKAPKARIGDLD
Position: 29-45
Source molecule (GenBank): NP_062723.1
Assay category: TCell
Result: Positive
Host:  10-14 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone

Epitope: Gabarap (29-45)
Chemical type: Peptide from protein
Sequence: VPVIVEKAPKARIGDLD
Position: 29-45
Source molecule (GenBank): NP_062723.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Gabarap (29-45)
Chemical type: Peptide from protein
Sequence: VPVIVEKAPKARIGDLD
Position: 29-45
Source molecule (GenBank): NP_062723.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 600.0

Epitope: CPH (348-363)
Chemical type: Peptide from protein
Sequence: KFPPEETLKSYWEDNK
Position: 348-363
Source molecule (GenBank): CAA43550.1
Assay category: MhcLigandElution
Result: Positive

Epitope: CPH (348-363)
Chemical type: Peptide from protein
Sequence: KFPPEETLKSYWEDNK
Position: 348-363
Source molecule (GenBank): CAA43550.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 600.0

Epitope: Lisch 7 (491--509)
Chemical type: Peptide from protein
Sequence: SGRPRARSVDALDDINRP
Position: 491-508
Source molecule (GenBank): AAA92719.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Lisch 7 (491--509)
Chemical type: Peptide from protein
Sequence: SGRPRARSVDALDDINRP
Position: 491-508
Source molecule (GenBank): AAA92719.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 2500.0

Epitope: Amyloid beta A4 (237-249)
Chemical type: Peptide from protein
Sequence: KSEFPTEADLEDF
Position: 237-249
Source molecule (GenBank): NP_033821.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Amyloid beta A4 (237-249)
Chemical type: Peptide from protein
Sequence: KSEFPTEADLEDF
Position: 237-249
Source molecule (GenBank): NP_033821.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 1300.0

Epitope: Amyloid beta A4 (479-489)
Chemical type: Peptide from protein
Sequence: VAEEIQDEVDE
Position: 587-597
Source molecule (GenBank): EDK98318.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Amyloid beta A4 (479-489)
Chemical type: Peptide from protein
Sequence: VAEEIQDEVDE
Position: 587-597
Source molecule (GenBank): EDK98318.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 2100.0

Epitope: Amyloid beta A4 (476-489)
Chemical type: Peptide from protein
Sequence: VPAVAEEIQDEVDE
Position: 584-597
Source molecule (GenBank): EDK98318.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Amyloid beta A4 (475-489)
Chemical type: Peptide from protein
Sequence: NVPAVAEEIQDEVDE
Position: 583-597
Source molecule (GenBank): EDK98318.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Amyloid beta A4 (524-539)
Chemical type: Peptide from protein
Sequence: ETKTTVELLPVNGEFS
Position: 632-647
Source molecule (GenBank): EDK98318.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Amyloid beta A4 (524-539)
Chemical type: Peptide from protein
Sequence: ETKTTVELLPVNGEFS
Position: 632-647
Source molecule (GenBank): EDK98318.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 200.0

Epitope: Slc12a7 (6-18)
Chemical type: Peptide from protein
Sequence: TVVPVEARADGAG
Position: 6-18
Source molecule (GenBank): NP_035520.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Slc12a7 (6-18)
Chemical type: Peptide from protein
Sequence: TVVPVEARADGAG
Position: 6-18
Source molecule (GenBank): NP_035520.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 3700.0

Epitope: CPH (348-363) analog
Chemical type: Peptide, no natural source
Sequence: KFPPEETLKSYWKDNK
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 13800.0

Epitope: Lisch 7 (491-509) analog
Chemical type: Peptide, no natural source
Sequence: SGRPRARSVDALDKINRP
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 14800.0

Epitope: Amyloid beta A4 (237-249) analog
Chemical type: Peptide, no natural source
Sequence: KSEFPTEADLKDF
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 30000.0