Reference: Wendy W Unger; Jurjen Velthuis; Joana R F Abreu; Sandra Laban; Edwin Quinten; Michel G D Kester; Sine Reker-Hadrup; Arnold H Bakker; Gaby Duinkerken; Arend Mulder; Kees L M C Franken; Robert Hilbrands; Bart Keymeulen; Mark Peakman; Ferry Ossendorp; Jan Wouter Drijfhout; Ton N Schumacher; Bart O Roep. "Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers." Journal of autoimmunity (2011).

Epitope: PPI (29-38)
Chemical type: Peptide from protein
Sequence: HLCGSHLVEA
Position: 29-38
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (29-38)
Chemical type: Peptide from protein
Sequence: HLCGSHLVEA
Position: 29-38
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (29-38)
Chemical type: Peptide from protein
Sequence: HLCGSHLVEA
Position: 29-38
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive

Epitope: PPI (9-18)
Chemical type: Peptide from protein
Sequence: PLLALLALWG
Position: 9-18
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (9-18)
Chemical type: Peptide from protein
Sequence: PLLALLALWG
Position: 9-18
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (9-18)
Chemical type: Peptide from protein
Sequence: PLLALLALWG
Position: 9-18
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive-Low
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (9-18)
Chemical type: Peptide from protein
Sequence: PLLALLALWG
Position: 9-18
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 32500.0

Epitope: PPI (76-84)
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 76-84
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (76-84)
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 76-84
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (76-84)
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 76-84
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (76-84)
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 76-84
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 115500.0

Epitope: PPI (79-88)
Chemical type: Peptide from protein
Sequence: PLALEGSLQK
Position: 79-88
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (79-88)
Chemical type: Peptide from protein
Sequence: PLALEGSLQK
Position: 79-88
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (79-88)
Chemical type: Peptide from protein
Sequence: PLALEGSLQK
Position: 79-88
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (79-88)
Chemical type: Peptide from protein
Sequence: PLALEGSLQK
Position: 79-88
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 141200.0

Epitope: PPI (4-13)
Chemical type: Peptide from protein
Sequence: WMRLLPLLAL
Position: 4-13
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (4-13)
Chemical type: Peptide from protein
Sequence: WMRLLPLLAL
Position: 4-13
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (4-13)
Chemical type: Peptide from protein
Sequence: WMRLLPLLAL
Position: 4-13
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (4-13)
Chemical type: Peptide from protein
Sequence: WMRLLPLLAL
Position: 4-13
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 992.1

Epitope: PPI (60-68)
Chemical type: Peptide from protein
Sequence: DLQVGQVEL
Position: 60-68
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: IGRP (265-273)
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): NP_066999.1
Assay category: MhcBinding
Result: Positive-High

Epitope: MAGE-1/A3
Chemical type: Peptide from protein
Sequence: SLFRAVITK
Position: 96-104
Source molecule (GenBank): P43355.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (85-93)
Chemical type: Peptide from protein
Sequence: SLQKRGIVE
Position: 85-93
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (85-93)
Chemical type: Peptide from protein
Sequence: SLQKRGIVE
Position: 85-93
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (85-93)
Chemical type: Peptide from protein
Sequence: SLQKRGIVE
Position: 85-93
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive

Epitope: PPI (18-26)
Chemical type: Peptide from protein
Sequence: GPDPAAAFV
Position: 18-26
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): NP_000198.1
Assay category: TCell
Result: Negative
Host:  child
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo