Reference: Menno van Lummel; Peter A van Veelen; Arnoud H de Ru; Jos Pool; Tatjana Nikolic; Sandra Laban; Antoinette Joosten; Jan W Drijfhout; Iria Gómez-Touriño; Sefina Arif; Henk J Aanstoot; Mark Peakman; Bart O Roep. "Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule." Diabetes (2016).

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (17-24)
Chemical type: Peptide from protein
Sequence: WGPDPAAA
Position: 17-24
Source molecule (GenBank): CAA08766.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 0.3

Epitope: PPI (54-69)
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVELG
Position: 54-69
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (54-69)
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVELG
Position: 54-69
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Negative

Epitope: PPI (54-69)
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVELG
Position: 54-69
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 64.0

Epitope: PPI (54-69)
Chemical type: Peptide from protein
Sequence: TRREAEDLQVGQVELG
Position: 54-69
Source molecule (GenBank): NP_000198.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 16.0

Epitope: IA-2 (142-159)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLPQ
Position: 142-159
Source molecule (GenBank): AAA90974.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (142-159)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLPQ
Position: 142-159
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (142-159)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLPQ
Position: 142-159
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (142-159)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLPQ
Position: 142-159
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 29.2

Epitope: IA-2 (142-159)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLPQ
Position: 142-159
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 17.7

Epitope: IA-2 (142-158)
Chemical type: Peptide from protein
Sequence: LQDIPTGSAPAAQHRLP
Position: 142-158
Source molecule (GenBank): AAA90974.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 68.6

Epitope: IA-2 (293-311)
Chemical type: Peptide from protein
Sequence: VPRLPEQGSSSRAEDSPEG
Position: 293-311
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 13.0

Epitope: IA-2 (319-332)
Chemical type: Peptide from protein
Sequence: DRGEKPASPAVQPD
Position: 319-332
Source molecule (GenBank): AAA90974.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (321-333)
Chemical type: Peptide from protein
Sequence: GEKPASPAVQPDA
Position: 321-333
Source molecule (GenBank): AAA90974.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  27 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: TCell
Result: Positive
MHC allele types: 710 105
Host:  17 +/- 6 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Negative

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 57.6

Epitope: IA-2 (318-333)
Chemical type: Peptide from protein
Sequence: GDRGEKPASPAVQPDA
Position: 318-333
Source molecule (GenBank): AAA90974.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 5.2