Reference: Mengyu Zhang; Wei Xu; Lingjie Luo; Fenghui Guan; Xiangyao Wang; Pei Zhu; Jianhua Zhang; Xuyu Zhou; Feng Wang; Sheng Ye. "Identification and affinity enhancement of T-cell receptor targeting a KRAS<sup>G12V</sup> cancer neoantigen." Communications biology (2024).

Epitope: KRAS 5-13
Chemical type: Peptide from protein
Sequence: KLVVVGAGG
Position: 5-13
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-13 G12D
Chemical type: Peptide, no natural source
Sequence: KLVVVGADG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-13 G12S
Chemical type: Peptide, no natural source
Sequence: KLVVVGASG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-13 G12V
Chemical type: Peptide, no natural source
Sequence: KLVVVGAVG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-14
Chemical type: Peptide from protein
Sequence: KLVVVGAGGV
Position: 5-14
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-14 G12C
Chemical type: Peptide, no natural source
Sequence: KLVVVGACGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-14 G12S
Chemical type: Peptide, no natural source
Sequence: KLVVVGASGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-14 G12V
Chemical type: Peptide, no natural source
Sequence: KLVVVGAVGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 5-14 G13D
Chemical type: Peptide, no natural source
Sequence: KLVVVGAGDV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 6-14
Chemical type: Peptide from protein
Sequence: LVVVGAGGV
Position: 6-14
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 6-14 G12D
Chemical type: Peptide, no natural source
Sequence: LVVVGADGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 6-14 G12S
Chemical type: Peptide, no natural source
Sequence: LVVVGASGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 6-14 G12V
Chemical type: Peptide, no natural source
Sequence: LVVVGAVGV
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 6-14 G13D
Chemical type: Peptide, no natural source
Sequence: LVVVGAGDV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: KRAS 7-15
Chemical type: Peptide from protein
Sequence: VVVGAGGVG
Position: 7-15
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 7-15 G12D
Chemical type: Peptide, no natural source
Sequence: VVVGADGVG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 7-15 G12S
Chemical type: Peptide, no natural source
Sequence: VVVGASGVG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 7-15 G12V
Chemical type: Peptide, no natural source
Sequence: VVVGAVGVG
Assay category: MhcBinding
Result: Negative

Epitope: KRAS 7-16
Chemical type: Peptide from protein
Sequence: VVVGAGGVGK
Position: 7-16
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 7-16 G12C
Chemical type: Peptide, no natural source
Sequence: VVVGACGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 7-16 G12D
Chemical type: Peptide, no natural source
Sequence: VVVGADGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 7-16 G12S
Chemical type: Peptide, no natural source
Sequence: VVVGASGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 7-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVVGAVGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 7-16 G13D
Chemical type: Peptide, no natural source
Sequence: VVVGAGDVGK
Assay category: TCell
Result: Negative
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 7-16 G13D
Chemical type: Peptide, no natural source
Sequence: VVVGAGDVGK
Assay category: TCell
Result: Positive
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 7-16 G13D
Chemical type: Peptide, no natural source
Sequence: VVVGAGDVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 8-16
Chemical type: Peptide from protein
Sequence: VVGAGGVGK
Position: 8-16
Source molecule (GenBank): P01116.1
Assay category: TCell
Result: Positive
Quantitative measurement: 1950.0
Host:  6-12 weeks

Epitope: KRAS 8-16
Chemical type: Peptide from protein
Sequence: VVGAGGVGK
Position: 8-16
Source molecule (GenBank): P01116.1
Assay category: TCell
Result: Positive-Low
Host:  6-12 weeks

Epitope: KRAS 8-16
Chemical type: Peptide from protein
Sequence: VVGAGGVGK
Position: 8-16
Source molecule (GenBank): P01116.1
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 8-16 G12C
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 8-16 G12D
Chemical type: Peptide, no natural source
Sequence: VVGADGVGK
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: KRAS 8-16 G12S
Chemical type: Peptide, no natural source
Sequence: VVGASGVGK
Assay category: TCell
Result: Negative
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12S
Chemical type: Peptide, no natural source
Sequence: VVGASGVGK
Assay category: TCell
Result: Positive
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12S
Chemical type: Peptide, no natural source
Sequence: VVGASGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 2650.0
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 2.17
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 2.36
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 30800.0
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 1950.0
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-Low
Host:  6-12 weeks

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Negative
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-High
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Negative
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  6-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.17

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.36

Epitope: KRAS 8-16 G12V
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS 8-16 G13D
Chemical type: Peptide, no natural source
Sequence: VVGAGDVGK
Assay category: MhcBinding
Result: Negative