Reference: Jonas S Heitmann; Yacine Maringer; Susanne Jung; Marcel Wacker; Christopher Hackenbruch; Mark Polster; Maddalena Marconato; Annika Nelde; Jens Bauer; Melissa Zwick; Anna-Sophia Baur; Ariane Lehmann; Christopher Krolla; Geoffroy Andrieux; Natalie Köhler; Melanie Boerries; Monika Denk; Lisa Zieschang; Christine Kammer; Naomi Hoenisch-Gravel; Marion Richter; Melek Tutku Oezbek; Stefan Wirths; Anna Dengler; Marissa L Dubbelaar; Marina Pumptow; Peter Martus; Monika Brüggemann; Hans-Georg Rammensee; Helmut R Salih; Juliane S Walz. "Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study." The Lancet. Haematology (2026).

Epitope: P1A*02
Chemical type: Peptide from protein
Sequence: ALHRPDVYL
Position: 325-333
Source molecule (GenBank): A0A1B0GUU9
Assay category: TCell
Result: Negative
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1A*02
Chemical type: Peptide from protein
Sequence: ALHRPDVYL
Position: 325-333
Source molecule (GenBank): A0A1B0GUU9
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 235

Epitope: P2A*02
Chemical type: Peptide from protein
Sequence: TLDTSKLYV
Position: 796-804
Source molecule (GenBank): Q13972.2
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2A*02
Chemical type: Peptide from protein
Sequence: TLDTSKLYV
Position: 796-804
Source molecule (GenBank): Q13972.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 235

Epitope: P3A*02
Chemical type: Peptide from protein
Sequence: VIAELPPKV
Position: 105-113
Source molecule (GenBank): A0A1B0GUU9
Assay category: TCell
Result: Negative
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P3A*02
Chemical type: Peptide from protein
Sequence: VIAELPPKV
Position: 105-113
Source molecule (GenBank): A0A1B0GUU9
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 235

Epitope: P1A*24
Chemical type: Peptide from protein
Sequence: GYMPYLNRF
Position: 68-76
Source molecule (GenBank): E9PJK8
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1A*24
Chemical type: Peptide from protein
Sequence: GYMPYLNRF
Position: 68-76
Source molecule (GenBank): E9PJK8
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 237

Epitope: P2A*24
Chemical type: Peptide from protein
Sequence: KYSKALIDYF
Position: 1085-1094
Source molecule (GenBank): P51826.3
Assay category: TCell
Result: Negative
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2A*24
Chemical type: Peptide from protein
Sequence: KYSKALIDYF
Position: 1085-1094
Source molecule (GenBank): P51826.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 237

Epitope: P3A*24
Chemical type: Peptide from protein
Sequence: RHTGALPLF
Position: 191-199
Source molecule (GenBank): O60292.3
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P3A*24
Chemical type: Peptide from protein
Sequence: RHTGALPLF
Position: 191-199
Source molecule (GenBank): O60292.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 237

Epitope: P1B*07
Chemical type: Peptide from protein
Sequence: LPRLEALDL
Position: 544-552
Source molecule (GenBank): Q9NR96.2
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1B*07
Chemical type: Peptide from protein
Sequence: LPRLEALDL
Position: 544-552
Source molecule (GenBank): Q9NR96.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 300

Epitope: P2B*07
Chemical type: Peptide from protein
Sequence: RPSNKAPLL
Position: 564-572
Source molecule (GenBank): Q9H9B1.4
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2B*07
Chemical type: Peptide from protein
Sequence: RPSNKAPLL
Position: 564-572
Source molecule (GenBank): Q9H9B1.4
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 300

Epitope: P1II
Chemical type: Peptide from protein
Sequence: AKPEASFQVWNKDSSSKNLI
Position: 87-106
Source molecule (GenBank): C9K0R8
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1II
Chemical type: Peptide from protein
Sequence: AKPEASFQVWNKDSSSKNLI
Position: 87-106
Source molecule (GenBank): C9K0R8
Assay category: TCell
Result: Negative
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1II
Chemical type: Peptide from protein
Sequence: AKPEASFQVWNKDSSSKNLI
Position: 87-106
Source molecule (GenBank): C9K0R8
Assay category: MhcLigandElution
Result: Positive

Epitope: P2II
Chemical type: Peptide from protein
Sequence: QPPDWLQGHYLVVRYEDL
Position: 411-428
Source molecule (GenBank): Q9Y4C5.2
Assay category: TCell
Result: Positive
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2II
Chemical type: Peptide from protein
Sequence: QPPDWLQGHYLVVRYEDL
Position: 411-428
Source molecule (GenBank): Q9Y4C5.2
Assay category: TCell
Result: Negative
Host:  > 18 years
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2II
Chemical type: Peptide from protein
Sequence: QPPDWLQGHYLVVRYEDL
Position: 411-428
Source molecule (GenBank): Q9Y4C5.2
Assay category: MhcLigandElution
Result: Positive