Reference: Arne Homann; Niels Röckendorf; Arno Kromminga; Andreas Frey; Thomas A Platts-Mills; Uta Jappe. "Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera." Theranostics (2017).

Epitope: alpha-Gal2
Chemical type: Carbohydrate
Assay category: BCell
Result: Negative

Epitope: alpha-Gal2
Chemical type: Carbohydrate
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: alpha-Gal2
Chemical type: Carbohydrate
Assay category: BCell
Result: Positive

Epitope: Adalimumab epitope 1
Chemical type: Peptide from protein
Sequence: AMHWVRQ
Position: 33-39
Source molecule (GenBank): 3WD5_H
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: Adalimumab epitope 1
Chemical type: Peptide from protein
Sequence: AMHWVRQ
Position: 33-39
Source molecule (GenBank): 3WD5_H
Assay category: BCell
Result: Positive

Epitope: Adalimumab epitope 2
Chemical type: Peptide from protein
Sequence: TAVYYCAKVSY
Position: 91-101
Source molecule (GenBank): 3WD5_H
Assay category: BCell
Result: Positive

Epitope: Adalimumab epitope 2
Chemical type: Peptide from protein
Sequence: TAVYYCAKVSY
Position: 91-101
Source molecule (GenBank): 3WD5_H
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: Adalimumab epitope 3
Chemical type: Peptide from protein
Sequence: ASQGIRNYLAW
Position: 25-35
Source molecule (GenBank): 4NYL_L
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: Adalimumab epitope 3
Chemical type: Peptide from protein
Sequence: ASQGIRNYLAW
Position: 25-35
Source molecule (GenBank): 4NYL_L
Assay category: BCell
Result: Positive

Epitope: Adalimumab epitope 4
Chemical type: Peptide from protein
Sequence: VATYYCQRYNR
Position: 83-93
Source molecule (GenBank): 4NYL_L
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: Adalimumab epitope 4
Chemical type: Peptide from protein
Sequence: VATYYCQRYNR
Position: 83-93
Source molecule (GenBank): 4NYL_L
Assay category: BCell
Result: Positive

Epitope: Adalimumab epitope 5
Chemical type: Peptide from protein
Sequence: SKLTVDKSRWQQG
Position: 291-303
Source molecule (GenBank): P01857.1
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: Adalimumab epitope 5
Chemical type: Peptide from protein
Sequence: SKLTVDKSRWQQG
Position: 291-303
Source molecule (GenBank): P01857.1
Assay category: BCell
Result: Positive

Epitope: random peptide F2
Chemical type: Peptide, no natural source
Sequence: ACPLAFATPIMIPQS
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide F2
Chemical type: Peptide, no natural source
Sequence: ACPLAFATPIMIPQS
Assay category: BCell
Result: Negative

Epitope: random peptide A3
Chemical type: Peptide, no natural source
Sequence: RVFDSGANEFLIEGI
Assay category: BCell
Result: Negative

Epitope: random peptide A3
Chemical type: Peptide, no natural source
Sequence: RVFDSGANEFLIEGI
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide B3
Chemical type: Peptide, no natural source
Sequence: LKMESEPVNGGNEVA
Assay category: BCell
Result: Negative

Epitope: random peptide B3
Chemical type: Peptide, no natural source
Sequence: LKMESEPVNGGNEVA
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide C3
Chemical type: Peptide, no natural source
Sequence: SRRGGVKVEELQDEI
Assay category: BCell
Result: Negative

Epitope: random peptide C3
Chemical type: Peptide, no natural source
Sequence: SRRGGVKVEELQDEI
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide E3
Chemical type: Peptide, no natural source
Sequence: EQLSVWSLIADRNIN
Assay category: BCell
Result: Negative

Epitope: random peptide E3
Chemical type: Peptide, no natural source
Sequence: EQLSVWSLIADRNIN
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide F3
Chemical type: Peptide, no natural source
Sequence: KEMDLLEMDSSDKGI
Assay category: BCell
Result: Negative

Epitope: random peptide F3
Chemical type: Peptide, no natural source
Sequence: KEMDLLEMDSSDKGI
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide A4
Chemical type: Peptide, no natural source
Sequence: CLLLSDGLFDRAAST
Assay category: BCell
Result: Negative

Epitope: random peptide A4
Chemical type: Peptide, no natural source
Sequence: CLLLSDGLFDRAAST
Assay category: BCell
Result: Negative
Host:  9-61 years

Epitope: random peptide C4
Chemical type: Peptide, no natural source
Sequence: ETKVSGIVICNPRDT
Assay category: BCell
Result: Negative

Epitope: random peptide C4
Chemical type: Peptide, no natural source
Sequence: ETKVSGIVICNPRDT
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: random peptide E4
Chemical type: Peptide, no natural source
Sequence: VWADASLFTFHYHQY
Assay category: BCell
Result: Negative

Epitope: random peptide E4
Chemical type: Peptide, no natural source
Sequence: VWADASLFTFHYHQY
Assay category: BCell
Result: Positive
Host:  9-61 years

Epitope: random peptide F4
Chemical type: Peptide, no natural source
Sequence: YHGTPYTTEYLPLGK
Assay category: BCell
Result: Positive

Epitope: random peptide F4
Chemical type: Peptide, no natural source
Sequence: YHGTPYTTEYLPLGK
Assay category: BCell
Result: Positive
Host:  9-61 years