Reference: Sophie A Valkenburg; Olive T W Li; Polly W Y Mak; Chris K P Mok; John M Nicholls; Yi Guan; Thomas A Waldmann; J S Malik Peiris; Liyanage P Perera; Leo L M Poon. "IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection." Proceedings of the National Academy of Sciences of the United States of America (2014).

Epitope: HA127 H5
Chemical type: Peptide from protein
Sequence: HFEKIQIIPKS
Position: 126-136
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA127 H7
Chemical type: Peptide from protein
Sequence: GIDKETMGFTY
Position: 125-135
Source molecule (GenBank): AAC40998.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA127 H1
Chemical type: Peptide from protein
Sequence: SFERFEIFPKT
Position: 127-137
Source molecule (GenBank): ACP41105.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA79 H5
Chemical type: Peptide from protein
Sequence: INGWAVYSKDNSIR
Position: 74-87
Source molecule (GenBank): AAT73329.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA79 H7
Chemical type: Peptide from protein
Sequence: VEGWVVIAKDNAVR
Position: 86-99
Source molecule (GenBank): AAR11362.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA79 H1
Chemical type: Peptide from protein
Sequence: INGWAVYSKDNSIR
Position: 74-87
Source molecule (GenBank): AAS89006.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA79 H3
Chemical type: Peptide from protein
Sequence: ITGFAPFSKDNSIR
Position: 94-107
Source molecule (GenBank): P06818.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA140 H5
Chemical type: Peptide from protein
Sequence: KSSFFRNVVWLIKKN
Position: 156-170
Source molecule (GenBank): ABP51977.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: bronchial aveolar lavage (BAL)
Culture conditions: Direct Ex Vivo

Epitope: HA140 H5
Chemical type: Peptide from protein
Sequence: KSSFFRNVVWLIKKN
Position: 156-170
Source molecule (GenBank): ABP51977.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA140 H7
Chemical type: Peptide from protein
Sequence: GSSFYAEMKWLLSNT
Position: 158-172
Source molecule (GenBank): AAR02640.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA140 H3
Chemical type: Peptide from protein
Sequence: GSGFFSRLNWLTKSG
Position: 160-174
Source molecule (GenBank): ABF83447.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H5
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H5
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H5
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: bronchial aveolar lavage (BAL)
Culture conditions: Direct Ex Vivo

Epitope: NP55 H5
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H5
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H7
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): ACZ46724.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H1
Chemical type: Peptide from protein
Sequence: RLIQNSITIERMVLS
Position: 55-69
Source molecule (GenBank): ACP41106.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H3
Chemical type: Peptide from protein
Sequence: RLIQNSLTIERMVLS
Position: 55-69
Source molecule (GenBank): AAK18005.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H3
Chemical type: Peptide from protein
Sequence: RLIQNSLTIERMVLS
Position: 55-69
Source molecule (GenBank): AAK18005.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H3
Chemical type: Peptide from protein
Sequence: RLIQNSLTIERMVLS
Position: 55-69
Source molecule (GenBank): AAK18005.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP55 H3
Chemical type: Peptide from protein
Sequence: RLIQNSLTIERMVLS
Position: 55-69
Source molecule (GenBank): AAK18005.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H5
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 535-543
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H5
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 535-543
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H5
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 535-543
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H5
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 535-543
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: bronchial aveolar lavage (BAL)
Culture conditions: Direct Ex Vivo

Epitope: HA518 H1
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 533-541
Source molecule (GenBank): P03452
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H7
Chemical type: Peptide from protein
Sequence: WFSTGASCF
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H3
Chemical type: Peptide from protein
Sequence: LRSLVASSG
Position: 108-116
Source molecule (GenBank): ABH00994.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H3
Chemical type: Peptide from protein
Sequence: LRSLVASSG
Position: 108-116
Source molecule (GenBank): ABH00994.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA518 H3
Chemical type: Peptide from protein
Sequence: LRSLVASSG
Position: 108-116
Source molecule (GenBank): ABH00994.1
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA211 H5
Chemical type: Peptide from protein
Sequence: YVKSNRLVLATGLRN
Position: 321-335
Source molecule (GenBank): Q6DQ33.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA211 H3
Chemical type: Peptide from protein
Sequence: YVKSTKLRLATGLRN
Position: 323-337
Source molecule (GenBank): ACP41105.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP311 H5
Chemical type: Peptide from protein
Sequence: QVFSLIRPNENPAHK
Position: 311-325
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP311 H3
Chemical type: Peptide from protein
Sequence: QVVSLMRPNENPAHK
Position: 311-325
Source molecule (GenBank): AHN13789.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP366 H5
Chemical type: Peptide from protein
Sequence: ASNENMEAM
Position: 366-374
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP366 H3
Chemical type: Peptide from protein
Sequence: ASNENVEIM
Position: 366-374
Source molecule (GenBank): AFP36155.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP 147
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP 147
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP 147
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): AAT70630.1
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: bronchial aveolar lavage (BAL)
Culture conditions: Direct Ex Vivo