Reference: Joar Esteban Pinto Torres; Mathieu Claes; Rik Hendrickx; Meng Yuan; Natalia Smiejkowska; Pieter Van Wielendaele; Aysima Hacisuleyman; Hans De Winter; Serge Muyldermans; Paul A M Michels; Malcolm D Walkinshaw; Wim Versées; Guy Caljon; Stefan Magez; Yann G-J Sterckx. "Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody." eLife (2025).

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 42.54

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 37.16

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.19

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.9

Epitope: Epitope of nanobody sdAb42 on Trypanosoma pyruvate kinase
Chemical type: Region on multi-chain protein
Discontinuous residues: A: Y143, P181, G182, C183, H243, Q247, V268, E269, I270, P271, K274; B: I12, F13, P15, R20, K43, S44, Q345, V348, R349, I352
Source molecule (GenBank): CCC94421.1
Assay category: BCell
Result: Positive