Reference: Heiko Mix; Christina Weiler-Normann; Robert Thimme; Golo Ahlenstiel; Eui-Cheol Shin; Johannes Herkel; Chella S David; Ansgar W Lohse; Barbara Rehermann. "Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis." Gastroenterology (2008).

Epitope: SLA/LP 1-20
Chemical type: Peptide from protein
Sequence: MSTSYGCFWRRFIHGIGRSG
Position: 1-20
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 9-28
Chemical type: Peptide from protein
Sequence: WRRFIHGIGRSGDISAVQPK
Position: 9-28
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 17-36
Chemical type: Peptide from protein
Sequence: GRSGDISAVQPKAAGSSLLN
Position: 17-36
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 25-44
Chemical type: Peptide from protein
Sequence: VQPKAAGSSLLNKITNSLVL
Position: 25-44
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 33-52
Chemical type: Peptide from protein
Sequence: SLLNKITNSLVLDIIKLAGV
Position: 33-52
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 41-60
Chemical type: Peptide from protein
Sequence: SLVLDIIKLAGVHTVANCFV
Position: 41-60
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 49-68
Chemical type: Peptide from protein
Sequence: LAGVHTVANCFVVPMATGMS
Position: 49-68
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 57-76
Chemical type: Peptide from protein
Sequence: NCFVVPMATGMSLTLCFLTL
Position: 57-76
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 65-84
Chemical type: Peptide from protein
Sequence: TGMSLTLCFLTLRHKRPKAK
Position: 65-84
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 73-92
Chemical type: Peptide from protein
Sequence: FLTLRHKRPKAKYIIWPRID
Position: 73-92
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 81-100
Chemical type: Peptide from protein
Sequence: PKAKYIIWPRIDQKSCFKSM
Position: 81-100
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 89-108
Chemical type: Peptide from protein
Sequence: PRIDQKSCFKSMITAGFEPV
Position: 89-108
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 97-116
Chemical type: Peptide from protein
Sequence: FKSMITAGFEPVVIENVLEG
Position: 97-116
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 105-124
Chemical type: Peptide from protein
Sequence: FEPVVIENVLEGDELRTDLK
Position: 105-124
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 113-132
Chemical type: Peptide from protein
Sequence: VLEGDELRTDLKAVEAKVQE
Position: 113-132
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 121-140
Chemical type: Peptide from protein
Sequence: TDLKAVEAKVQELGPDCILC
Position: 121-140
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 129-148
Chemical type: Peptide from protein
Sequence: KVQELGPDCILCIHSTTSCF
Position: 129-148
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 137-156
Chemical type: Peptide from protein
Sequence: CILCIHSTTSCFAPRVPDRL
Position: 137-156
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 145-164
Chemical type: Peptide from protein
Sequence: TSCFAPRVPDRLEELAVICA
Position: 145-164
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 153-172
Chemical type: Peptide from protein
Sequence: PDRLEELAVICANYDIPHIV
Position: 153-172
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 161-180
Chemical type: Peptide from protein
Sequence: VICANYDIPHIVNNAYGVQS
Position: 161-180
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 169-188
Chemical type: Peptide from protein
Sequence: PHIVNNAYGVQSSKCMHLIQ
Position: 169-188
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 177-196
Chemical type: Peptide from protein
Sequence: GVQSSKCMHLIQQGARVGRI
Position: 177-196
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host: F 23-77 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host: F 23-77 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 186-197
Chemical type: Peptide from protein
Sequence: LIQQGARVGRID
Position: 186-197
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 193-212
Chemical type: Peptide from protein
Sequence: VGRIDAFVQSLDKNFMVPVG
Position: 193-212
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 201-220
Chemical type: Peptide from protein
Sequence: QSLDKNFMVPVGGAIIAGFN
Position: 201-220
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 209-228
Chemical type: Peptide from protein
Sequence: VPVGGAIIAGFNDSFIQEIS
Position: 209-228
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 217-236
Chemical type: Peptide from protein
Sequence: AGFNDSFIQEISKMYPGRAS
Position: 217-236
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 225-244
Chemical type: Peptide from protein
Sequence: QEISKMYPGRASASPSLDVL
Position: 225-244
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 225-244
Chemical type: Peptide from protein
Sequence: GRASASPSLDVLITLLSLGS
Position: 233-252
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 241-260
Chemical type: Peptide from protein
Sequence: LDVLITLLSLGSNGYKKLLK
Position: 241-260
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 249-268
Chemical type: Peptide from protein
Sequence: SLGSNGYKKLLKERKEMFSY
Position: 249-268
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 264-275
Chemical type: Peptide from protein
Sequence: EMFSYLSNQIKK
Position: 264-275
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: SLA/LP 264-275
Chemical type: Peptide from protein
Sequence: EMFSYLSNQIKK
Position: 264-275
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 265-284
Chemical type: Peptide from protein
Sequence: MFSYLSNQIKKLSEAYNERL
Position: 265-284
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 273-292
Chemical type: Peptide from protein
Sequence: IKKLSEAYNERLLHTPHNPI
Position: 273-292
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 281-300
Chemical type: Peptide from protein
Sequence: NERLLHTPHNPISLAMTLKT
Position: 281-300
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 289-308
Chemical type: Peptide from protein
Sequence: HNPISLAMTLKTLDEHRDKA
Position: 289-308
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 305-324
Chemical type: Peptide from protein
Sequence: RDKAVTQLGSMLFTKQVSGA
Position: 305-324
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 321-340
Chemical type: Peptide from protein
Sequence: VSGARVVPLGSMQTVSGYTF
Position: 321-340
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 329-348
Chemical type: Peptide from protein
Sequence: LGSMQTVSGYTFRGFMSHTN
Position: 329-348
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 337-356
Chemical type: Peptide from protein
Sequence: GYTFRGFMSHTNNYPCAYLN
Position: 337-356
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 345-364
Chemical type: Peptide from protein
Sequence: SHTNNYPCAYLNAASAIGMK
Position: 345-364
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 353-372
Chemical type: Peptide from protein
Sequence: AYLNAASAIGMKMQDVDLFI
Position: 353-372
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host: F 23-77 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host: F 23-77 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 373-386
Chemical type: Peptide from protein
Sequence: NRLDRCLKAVRKER
Position: 373-386
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host: F 23-77 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 377-396
Chemical type: Peptide from protein
Sequence: RCLKAVRKERSKESDDNYDK
Position: 377-396
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 385-404
Chemical type: Peptide from protein
Sequence: ERSKESDDNYDKTEDVDIEE
Position: 385-404
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 393-412
Chemical type: Peptide from protein
Sequence: NYDKTEDVDIEEMALKLDNV
Position: 393-412
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Negative
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 400-419
Chemical type: Peptide from protein
Sequence: VDIEEMALKLDNVLLDTYQD
Position: 400-419
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 403-422
Chemical type: Peptide from protein
Sequence: EEMALKLDNVLLDTYQDASS
Position: 403-422
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks

Epitope: SLA/LP 403-422
Chemical type: Peptide from protein
Sequence: EEMALKLDNVLLDTYQDASS
Position: 403-422
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Positive
Host:  8-12 weeks

Epitope: SLA/LP 403-422
Chemical type: Peptide from protein
Sequence: EEMALKLDNVLLDTYQDASS
Position: 403-422
Source molecule (GenBank): AAD33963.2
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: SLA/LP 354-373
Chemical type: Peptide from protein
Sequence: YLNAASAIGMKMQDVDLFIN
Position: 354-373
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks

Epitope: SLA/LP 354-373
Chemical type: Peptide from protein
Sequence: YLNAASAIGMKMQDVDLFIN
Position: 354-373
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks

Epitope: SLA/LP 374-393
Chemical type: Peptide from protein
Sequence: RLDRCLKAVRKERSKESDDN
Position: 374-393
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Positive
Host:  8-12 weeks

Epitope: SLA/LP 374-393
Chemical type: Peptide from protein
Sequence: RLDRCLKAVRKERSKESDDN
Position: 374-393
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Positive
Host:  8-12 weeks

Epitope: SLA/LP 379-398
Chemical type: Peptide from protein
Sequence: LKAVRKERSKESDDNYDKTE
Position: 379-398
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks

Epitope: SLA/LP 379-398
Chemical type: Peptide from protein
Sequence: LKAVRKERSKESDDNYDKTE
Position: 379-398
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Positive
Host:  8-12 weeks

Epitope: SLA/LP 399-418
Chemical type: Peptide from protein
Sequence: DVDIEEMALKLDNVLLDTYQ
Position: 399-418
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks

Epitope: SLA/LP 399-418
Chemical type: Peptide from protein
Sequence: DVDIEEMALKLDNVLLDTYQ
Position: 399-418
Source molecule (GenBank): AAD33963.2
Assay category: BCell
Result: Negative
Host:  8-12 weeks