Reference: Mai T Tran; Jia Jia Lim; Tiing Jen Loh; Stuart I Mannering; Jamie Rossjohn; Hugh H Reid. "A structural basis of T cell cross-reactivity to native and spliced self-antigens presented by HLA-DQ8." The Journal of biological chemistry (2024).

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 2.59

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 9800.0

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 176500.0

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 9400.0

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 3500.0

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 15200.0

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.6

Epitope: PI 40-54 G9E L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESCQ
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.59

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive
Quantitative measurement: 36400.0

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive
Quantitative measurement: 65000.0

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive
Quantitative measurement: 45000.0

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive
Quantitative measurement: 65300.0

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 116900.0

Epitope: Hybrid insulin peptide (HIP3 L11C;PI 40-47-NPY 68-74 L11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGSSPETCI
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.6

Epitope: Hybrid insulin peptide (HIP3;PI 40-47-NPY 68-74)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP3;PI 40-47-NPY 68-74)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP3;PI 40-47-NPY 68-74)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP3;PI 40-47-NPY 68-74)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP2 H11C; PI 40-47-IAPP2 23-29 H11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGTPIESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 44800.0

Epitope: Hybrid insulin peptide (HIP2 H11C; PI 40-47-IAPP2 23-29 H11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGTPIESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 46600.0

Epitope: Hybrid insulin peptide (HIP2 H11C; PI 40-47-IAPP2 23-29 H11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGTPIESCQ
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 189100.0

Epitope: Hybrid insulin peptide (HIP2 H11C; PI 40-47-IAPP2 23-29 H11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGTPIESCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 2.9

Epitope: Hybrid insulin peptide (HIP2 H11C; PI 40-47-IAPP2 23-29 H11C)
Chemical type: Peptide, no natural source
Sequence: GQVELGGGTPIESCQ
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.9

Epitope: Hybrid insulin peptide (HIP2; PI 40-47-IAPP2 23-29)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP2; PI 40-47-IAPP2 23-29)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Quantitative measurement: 65000.0

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Quantitative measurement: 44800.0

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: Hybrid insulin peptide (HIP1; PI 40-47-IAPP2 74-80)
Chemical type: Spliced peptide from proteins
Position: 64-71
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Quantitative measurement: 3900.0

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Quantitative measurement: 3500.0

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Quantitative measurement: 45000.0

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 G9E
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAESLQ
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: PI 40-54 L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAGSCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 13600.0

Epitope: PI 40-54 L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAGSCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 3900.0

Epitope: PI 40-54 L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAGSCQ
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 169900.0

Epitope: PI 40-54 L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAGSCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 12500.0

Epitope: PI 40-54 L11C
Chemical type: Peptide, no natural source
Sequence: GQVELGGGPGAGSCQ
Assay category: TCell
Result: Positive
Quantitative measurement: 6600.0