Reference: Nayanendu Saha; Sang Gyu Lee; Eeva-Christine Brockmann; M Jason de la Cruz; Yehuda Goldgur; Rachelle P Mendoza; Elisa de Stanchina; Tanzy M Love; Josh Marvald; Yan Xu; Kai Xu; Juha P Himanen; Urpo Lamminmäki; Darren Veach; Dimitar B Nikolov. "Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2024).

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive
Quantitative measurement: 25.0

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab C12 on ADAM17-ECD
Chemical type: Discontinuous protein residues
Discontinuous residues: K572, K574, I579, P580, R584, Q586, Q587, L588, E589, D606, L607, S608, G609
Source molecule (GenBank): P78536.1
Assay category: BCell
Result: Positive