Reference: Liselotte Jansson; Kathleen Vrolix; Andrea Jahraus; Keith F Martin; David C Wraith. "Immunotherapy With Apitopes Blocks the Immune Response to TSH Receptor in HLA-DR Transgenic Mice." Endocrinology (2018).

Epitope: TSHR 64-92 peptide 4
Chemical type: Peptide from protein
Sequence: LRTIPSHAFSNLPNISRIYVSIDVTLQQL
Position: 64-92
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 64-92 peptide 4
Chemical type: Peptide from protein
Sequence: LRTIPSHAFSNLPNISRIYVSIDVTLQQL
Position: 64-92
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 64-92 peptide 4
Chemical type: Peptide from protein
Sequence: LRTIPSHAFSNLPNISRIYVSIDVTLQQL
Position: 64-92
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 78-107 peptide 5
Chemical type: Peptide from protein
Sequence: ISRIYVSIDVTLQQLESHSFYNLSKVTHI
Position: 78-106
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 78-107 peptide 5
Chemical type: Peptide from protein
Sequence: ISRIYVSIDVTLQQLESHSFYNLSKVTHI
Position: 78-106
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 78-107 peptide 5
Chemical type: Peptide from protein
Sequence: ISRIYVSIDVTLQQLESHSFYNLSKVTHI
Position: 78-106
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 136–164 peptide 9
Chemical type: Peptide from protein
Sequence: TGLKMFPDLTKVYSTDIFFILEITDNPYM
Position: 136-164
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 136–164 peptide 9
Chemical type: Peptide from protein
Sequence: TGLKMFPDLTKVYSTDIFFILEITDNPYM
Position: 136-164
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 136–164 peptide 9
Chemical type: Peptide from protein
Sequence: TGLKMFPDLTKVYSTDIFFILEITDNPYM
Position: 136-164
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 74-88 peptide 4K
Chemical type: Peptide from protein
Sequence: NLPNISRIYVSIDVT
Position: 74-88
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 74-88 peptide 4K
Chemical type: Peptide from protein
Sequence: NLPNISRIYVSIDVT
Position: 74-88
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 74-88 peptide 4K
Chemical type: Peptide from protein
Sequence: NLPNISRIYVSIDVT
Position: 74-88
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 81-95 peptide 5D
Chemical type: Peptide from protein
Sequence: IYVSIDVTLQQLESH
Position: 81-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 81-95 peptide 5D
Chemical type: Peptide from protein
Sequence: IYVSIDVTLQQLESH
Position: 81-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 81-95 peptide 5D
Chemical type: Peptide from protein
Sequence: IYVSIDVTLQQLESH
Position: 81-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 82-95 peptide 5DK
Chemical type: Peptide from protein
Sequence: YVSIDVTLQQLESH
Position: 82-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR 82-95 peptide 5DK
Chemical type: Peptide from protein
Sequence: YVSIDVTLQQLESH
Position: 82-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Host:  6-10 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: TSHR 82-95 peptide 5DK
Chemical type: Peptide from protein
Sequence: YVSIDVTLQQLESH
Position: 82-95
Source molecule (GenBank): P16473.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TSHR 74-88 peptide 4KG
Chemical type: Peptide, no natural source
Sequence: KKGNLPNISRIYVSIDVTGKK
Assay category: MhcBinding
Result: Negative

Epitope: TSHR 74-88 peptide 4KG
Chemical type: Peptide, no natural source
Sequence: KKGNLPNISRIYVSIDVTGKK
Assay category: MhcBinding
Result: Positive

Epitope: TSHR 74-88 peptide 4KG
Chemical type: Peptide, no natural source
Sequence: KKGNLPNISRIYVSIDVTGKK
Assay category: MhcBinding
Result: Positive-Low

Epitope: TSHR 74-88 peptide 4KG
Chemical type: Peptide, no natural source
Sequence: KKGNLPNISRIYVSIDVTGKK
Assay category: MhcBinding
Result: Positive

Epitope: TSHR 74-88 peptide 4KG
Chemical type: Peptide, no natural source
Sequence: KKGNLPNISRIYVSIDVTGKK
Assay category: MhcBinding
Result: Positive-Low

Epitope: TSHR 82-95 peptide 5DK analog
Chemical type: Peptide, no natural source
Sequence: KKKKYVSIDVTLQQLESHKKK
Assay category: MhcBinding
Result: Positive-Low

Epitope: TSHR 82-95 peptide 5DK analog
Chemical type: Peptide, no natural source
Sequence: KKKKYVSIDVTLQQLESHKKK
Assay category: MhcBinding
Result: Positive-Low

Epitope: TSHR 82-95 peptide 5DK analog
Chemical type: Peptide, no natural source
Sequence: KKKKYVSIDVTLQQLESHKKK
Assay category: MhcBinding
Result: Positive

Epitope: TSHR 82-95 peptide 5DK analog
Chemical type: Peptide, no natural source
Sequence: KKKKYVSIDVTLQQLESHKKK
Assay category: MhcBinding
Result: Positive

Epitope: TSHR 82-95 peptide 5DK analog
Chemical type: Peptide, no natural source
Sequence: KKKKYVSIDVTLQQLESHKKK
Assay category: MhcBinding
Result: Positive