Reference: Jenna J Guthmiller; Julianna Han; Lei Li; Alec W Freyn; Sean T H Liu; Olivia Stovicek; Christopher T Stamper; Haley L Dugan; Micah E Tepora; Henry A Utset; Dalia J Bitar; Natalie J Hamel; Siriruk Changrob; Nai-Ying Zheng; Min Huang; Florian Krammer; Raffael Nachbagauer; Peter Palese; Andrew B Ward; Patrick C Wilson. "First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes." Science translational medicine (2021).

Epitope: HA208-216
Chemical type: Peptide from protein
Sequence: LYQNADAYV
Position: 208-216
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA208-216
Chemical type: Peptide from protein
Sequence: LYQNADAYV
Position: 208-216
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA462-470
Chemical type: Peptide from protein
Sequence: LYEKVRSQL
Position: 462-470
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA462-470
Chemical type: Peptide from protein
Sequence: LYEKVRSQL
Position: 462-470
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA462-470
Chemical type: Peptide from protein
Sequence: LYEKVRSQL
Position: 462-470
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Negative

Epitope: HA533-541
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 533-541
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA533-541
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 533-541
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: HA533-541
Chemical type: Peptide from protein
Sequence: IYSTVASSL
Position: 533-541
Source molecule (GenBank): ACR47014.1
Assay category: TCell
Result: Negative

Epitope: M131-39
Chemical type: Peptide from protein
Sequence: VFAGKNTDL
Position: 31-39
Source molecule (GenBank): ADE29098.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: M131-39
Chemical type: Peptide from protein
Sequence: VFAGKNTDL
Position: 31-39
Source molecule (GenBank): ADE29098.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: M131-39
Chemical type: Peptide from protein
Sequence: VFAGKNTDL
Position: 31-39
Source molecule (GenBank): ADE29098.1
Assay category: TCell
Result: Positive

Epitope: M199-107
Chemical type: Peptide from protein
Sequence: LYRKLKREI
Position: 99-107
Source molecule (GenBank): ADE29098.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: M199-107
Chemical type: Peptide from protein
Sequence: LYRKLKREI
Position: 99-107
Source molecule (GenBank): ADE29098.1
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: M251-59
Chemical type: Peptide from protein
Sequence: IYRRFKYGL
Position: 51-59
Source molecule (GenBank): ADE29099.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: M251-59
Chemical type: Peptide from protein
Sequence: IYRRFKYGL
Position: 51-59
Source molecule (GenBank): ADE29099.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA131-139
Chemical type: Peptide from protein
Sequence: TFFLTQGAL
Position: 131-139
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA131-139
Chemical type: Peptide from protein
Sequence: TFFLTQGAL
Position: 131-139
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA131-139
Chemical type: Peptide from protein
Sequence: TFFLTQGAL
Position: 131-139
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Negative

Epitope: NA207-215
Chemical type: Peptide from protein
Sequence: KYNGIITDT
Position: 207-215
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA207-215
Chemical type: Peptide from protein
Sequence: KYNGIITDT
Position: 207-215
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA207-215
Chemical type: Peptide from protein
Sequence: KYNGIITDT
Position: 207-215
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Negative

Epitope: NA435-443
Chemical type: Peptide from protein
Sequence: TIWTSGSSI
Position: 435-443
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA435-443
Chemical type: Peptide from protein
Sequence: TIWTSGSSI
Position: 435-443
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NA435-443
Chemical type: Peptide from protein
Sequence: TIWTSGSSI
Position: 435-443
Source molecule (GenBank): ACR47015.1
Assay category: TCell
Result: Negative

Epitope: NP39-47
Chemical type: Peptide from protein
Sequence: FYIQMCTEL
Position: 39-47
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP39-47
Chemical type: Peptide from protein
Sequence: FYIQMCTEL
Position: 39-47
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP39-47
Chemical type: Peptide from protein
Sequence: FYIQMCTEL
Position: 39-47
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive

Epitope: NP147-155
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive

Epitope: NP147-155
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: NP147-155
Chemical type: Peptide from protein
Sequence: TYQRTRALV
Position: 147-155
Source molecule (GenBank): ADE29096.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PA34-42
Chemical type: Peptide from protein
Sequence: KFAAICTHL
Position: 34-42
Source molecule (GenBank): ADE29094.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PA34-42
Chemical type: Peptide from protein
Sequence: KFAAICTHL
Position: 34-42
Source molecule (GenBank): ADE29094.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PA34-42
Chemical type: Peptide from protein
Sequence: KFAAICTHL
Position: 34-42
Source molecule (GenBank): ADE29094.1
Assay category: TCell
Result: Negative

Epitope: PB181-89
Chemical type: Peptide from protein
Sequence: GYAQTDCVL
Position: 81-89
Source molecule (GenBank): ADE29093.1
Assay category: TCell
Result: Positive-Low
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PB181-89
Chemical type: Peptide from protein
Sequence: GYAQTDCVL
Position: 81-89
Source molecule (GenBank): ADE29093.1
Assay category: TCell
Result: Positive

Epitope: PB181-89
Chemical type: Peptide from protein
Sequence: GYAQTDCVL
Position: 81-89
Source molecule (GenBank): ADE29093.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PB2599-2607
Chemical type: Peptide from protein
Sequence: LFQQMRDVL
Position: 599-607
Source molecule (GenBank): ADE29092.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PB2599-2607
Chemical type: Peptide from protein
Sequence: LFQQMRDVL
Position: 599-607
Source molecule (GenBank): ADE29092.1
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo