Reference: Sara Bobisse; Raphael Genolet; Annalisa Roberti; Janos L Tanyi; Julien Racle; Brian J Stevenson; Christian Iseli; Alexandra Michel; Marie-Aude Le Bitoux; Philippe Guillaume; Julien Schmidt; Valentina Bianchi; Denarda Dangaj; Craig Fenwick; Laurent Derré; Ioannis Xenarios; Olivier Michielin; Pedro Romero; Dimitri S Monos; Vincent Zoete; David Gfeller; Lana E Kandalaft; George Coukos; Alexandre Harari. "Sensitive and frequent identification of high avidity neo-epitope specific CD8 <sup>+</sup> T cells in immunotherapy-naive ovarian cancer." Nature communications (2018).

Epitope: HLA-DRB1 I248L
Chemical type: Peptide, no natural source
Sequence: FLGAGLFLYF
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: HLA-DRB1 I248L
Chemical type: Peptide, no natural source
Sequence: FLGAGLFLYF
Assay category: TCell
Result: Negative
Host: F 49 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: HS6ST1 S405I
Chemical type: Peptide, no natural source
Sequence: DYMIHIIEKW
Assay category: TCell
Result: Negative
Host: F 60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HS6ST1 S405I
Chemical type: Peptide, no natural source
Sequence: DYMIHIIEKW
Assay category: TCell
Result: Positive
Host: F 60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: COPG2 T37I
Chemical type: Peptide, no natural source
Sequence: IPINPRRCL
Assay category: TCell
Result: Positive
Host: F 72 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: COPG2 T37I
Chemical type: Peptide, no natural source
Sequence: IPINPRRCL
Assay category: TCell
Result: Negative
Host: F 72 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: TRIM26 G497W
Chemical type: Peptide, no natural source
Sequence: LDYEWGTVTF
Assay category: TCell
Result: Positive
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: TRIM26 G497W
Chemical type: Peptide, no natural source
Sequence: LDYEWGTVTF
Assay category: TCell
Result: Positive
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: TRIM26 G497W
Chemical type: Peptide, no natural source
Sequence: LDYEWGTVTF
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: EBF4 I510S
Chemical type: Peptide, no natural source
Sequence: ASMPSSPPL
Assay category: TCell
Result: Positive
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: EBF4 I510S
Chemical type: Peptide, no natural source
Sequence: ASMPSSPPL
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: DCHS1 P141L
Chemical type: Peptide, no natural source
Sequence: VADINDHAL
Assay category: TCell
Result: Positive
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: DCHS1 P141L
Chemical type: Peptide, no natural source
Sequence: VADINDHAL
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KIR2DS4 I7S
Chemical type: Peptide, no natural source
Sequence: SMACVGFFL
Assay category: TCell
Result: Positive
Host: F 68 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KIR2DS4 I7S
Chemical type: Peptide, no natural source
Sequence: SMACVGFFL
Assay category: TCell
Result: Positive
Host: F 68 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KIR2DS4 I7S
Chemical type: Peptide, no natural source
Sequence: SMACVGFFL
Assay category: TCell
Result: Positive
Host: F 68 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KIR2DS4 I7S
Chemical type: Peptide, no natural source
Sequence: SMACVGFFL
Assay category: TCell
Result: Negative
Host: F 68 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KIR2DS4 I7S
Chemical type: Peptide, no natural source
Sequence: SMACVGFFL
Assay category: TCell
Result: Positive
Host: F 68 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PDPN G222C
Chemical type: Peptide, no natural source
Sequence: FICAIIVVV
Assay category: TCell
Result: Positive
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PDPN G222C
Chemical type: Peptide, no natural source
Sequence: FICAIIVVV
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: T cell CD8+
Tissue: ovary
Culture conditions: Cell Line / Clone

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Negative
Host: F 49 years
Cell type: T cell CD8+
Tissue: ovary
Culture conditions: Cell Line / Clone

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: T cell CD8+
Tissue: ovary
Culture conditions: Cell Line / Clone

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Negative
Host: F 49 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Positive
Host: F 49 years
Cell type: T cell CD8+
Tissue: ovary
Culture conditions: Cell Line / Clone

Epitope: HHAT L75F
Chemical type: Peptide, no natural source
Sequence: KQWLVWLFL
Assay category: TCell
Result: Negative
Host: F 49 years
Cell type: T cell CD8+
Tissue: ovary
Culture conditions: Cell Line / Clone

Epitope: USP47 V170L
Chemical type: Peptide, no natural source
Sequence: TSDYLSQSY
Assay category: TCell
Result: Positive
Host: F 43 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: USP47 V170L
Chemical type: Peptide, no natural source
Sequence: TSDYLSQSY
Assay category: TCell
Result: Negative
Host: F 43 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: OR2T3 C132Y
Chemical type: Peptide, no natural source
Sequence: VYRPLHYPLL
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: OR2T3 C132Y
Chemical type: Peptide, no natural source
Sequence: VYRPLHYPLL
Assay category: TCell
Result: Positive
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: TP53 A159V
Chemical type: Peptide, no natural source
Sequence: RVRVMAIYK
Assay category: TCell
Result: Positive
Host: F 47 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: TP53 A159V
Chemical type: Peptide, no natural source
Sequence: RVRVMAIYK
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: ODZ3 A2490V
Chemical type: Peptide, no natural source
Sequence: GAQSWLWFV
Assay category: TCell
Result: Positive
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ODZ3 A2490V
Chemical type: Peptide, no natural source
Sequence: GAQSWLWFV
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HS6ST1
Chemical type: Peptide from protein
Sequence: DYMSHIIEKW
Position: 402-411
Source molecule (GenBank): O60243.5
Assay category: TCell
Result: Negative
Host: F 60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: COPG2
Chemical type: Peptide from protein
Sequence: TPINPRRCL
Position: 37-45
Source molecule (GenBank): Q9UBF2.1
Assay category: TCell
Result: Negative
Host: F 72 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: EBF4
Chemical type: Peptide from protein
Sequence: AIMPSSPPL
Position: 513-521
Source molecule (GenBank): Q9BQW3.2
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: DCHS1
Chemical type: Peptide from protein
Sequence: VADINDHAP
Position: 133-141
Source molecule (GenBank): Q96JQ0.1
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: SEPT9
Chemical type: Peptide from protein
Sequence: SILEQMRRK
Position: 283-291
Source molecule (GenBank): Q9UHD8.2
Assay category: TCell
Result: Negative
Host: F 63 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: PDPN
Chemical type: Peptide from protein
Sequence: FIGAIIVVV
Position: 144-152
Source molecule (GenBank): Q86YL7.3
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: USP47
Chemical type: Peptide from protein
Sequence: TSDYVSQSY
Position: 166-174
Source molecule (GenBank): Q96K76.3
Assay category: TCell
Result: Negative
Host: F 43 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: ZCCHC11
Chemical type: Peptide from protein
Sequence: GRKLFGTPF
Position: 1258-1266
Source molecule (GenBank): Q5TAX3.3
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: OR2T3
Chemical type: Peptide from protein
Sequence: VCRPLHYPLL
Position: 131-140
Source molecule (GenBank): Q8NH03.2
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: TP53
Chemical type: Peptide from protein
Sequence: RVRAMAIYK
Position: 156-164
Source molecule (GenBank): P04637.4
Assay category: TCell
Result: Negative
Host: F 47 years
Cell type: tumor infiltrating lymphocyte
Tissue: ovary
Culture conditions: Short Term Restimulated

Epitope: ODZ3
Chemical type: Peptide from protein
Sequence: GAQSWLWFA
Position: 2482-2490
Source molecule (GenBank): Q9P273.3
Assay category: TCell
Result: Negative
Host: F 61 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated