Reference: G R Vreugdenhil; A Geluk; T H Ottenhoff; W J Melchers; B O Roep; J M Galama. "Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule." Diabetologia (1998).

Epitope: GAD<sub>65</sub> 20-mer
Chemical type: Peptide from protein
Sequence: AMMIARFKMFPEVKEKGMAA
Position: 250-269
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 20000.0

Epitope: GAD<sub>65</sub> 20-mer
Chemical type: Peptide from protein
Sequence: AMMIARFKMFPEVKEKGMAA
Position: 250-269
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 16020.0

Epitope: GAD<sub>65</sub> 20-mer
Chemical type: Peptide from protein
Sequence: AMMIARFKMFPEVKEKGMAA
Position: 250-269
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2590.0

Epitope: CVB4 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVKEKHEFL
Position: 1126-1145
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 16500.0

Epitope: CVB4 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVKEKHEFL
Position: 1126-1145
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1870.0

Epitope: CVB4 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVKEKHEFL
Position: 1126-1145
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 19800.0

Epitope: CVB3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVREKHEFL
Position: 1128-1147
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 5880.0

Epitope: CVB3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVREKHEFL
Position: 1128-1147
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 16600.0

Epitope: CVB3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIEWLKVKILPEVREKHEFL
Position: 1128-1147
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1360.0

Epitope: PV3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIDWLRERIIPQARDKLEFV
Position: 1152-1171
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 660.0

Epitope: PV3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIDWLRERIIPQARDKLEFV
Position: 1152-1171
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2400.0

Epitope: PV3 p2C 20-mer
Chemical type: Peptide from protein
Sequence: FIDWLRERIIPQARDKLEFV
Position: 1152-1171
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1100.0

Epitope: GAD<sub>65</sub> 12-mer
Chemical type: Peptide from protein
Sequence: FKMFPEVKEKGM
Position: 256-267
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 18000.0

Epitope: GAD<sub>65</sub> 12-mer
Chemical type: Peptide from protein
Sequence: FKMFPEVKEKGM
Position: 256-267
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Negative

Epitope: GAD<sub>65</sub> 12-mer
Chemical type: Peptide from protein
Sequence: FKMFPEVKEKGM
Position: 256-267
Source molecule (GenBank): Q05329.1
Assay category: MhcBinding
Result: Negative

Epitope: CVB4 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVKEKHE
Position: 1132-1143
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Negative

Epitope: CVB4 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVKEKHE
Position: 1132-1143
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Negative

Epitope: CVB4 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVKEKHE
Position: 1132-1143
Source molecule (GenBank): CAA29172.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 15000.0

Epitope: CVB3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVREKHE
Position: 1134-1145
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 16800.0

Epitope: CVB3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVREKHE
Position: 1134-1145
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Negative

Epitope: CVB3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: VKILPEVREKHE
Position: 1134-1145
Source molecule (GenBank): AAA74400.1
Assay category: MhcBinding
Result: Negative

Epitope: PV3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: ERIIPQARDKLE
Position: 1158-1169
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Negative

Epitope: PV3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: ERIIPQARDKLE
Position: 1158-1169
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 4800.0

Epitope: PV3 p2C 12-mer
Chemical type: Peptide from protein
Sequence: ERIIPQARDKLE
Position: 1158-1169
Source molecule (GenBank): P03302.3
Assay category: MhcBinding
Result: Negative

Epitope: p2C E<sub>2</sub>-D 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPDVKEKHE
Assay category: MhcBinding
Result: Negative

Epitope: p2C E<sub>2</sub>-D 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPDVKEKHE
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 600.0

Epitope: p2C E<sub>2</sub>-D 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPDVKEKHE
Assay category: MhcBinding
Result: Negative

Epitope: p2C E<sub>2</sub>-V 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPVVKEKHE
Assay category: MhcBinding
Result: Negative

Epitope: p2C E<sub>2</sub>-V 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPVVKEKHE
Assay category: MhcBinding
Result: Negative

Epitope: p2C E<sub>2</sub>-V 12-mer
Chemical type: Peptide, no natural source
Sequence: VKILPVVKEKHE
Assay category: MhcBinding
Result: Negative