Reference: Andrew I Flyak; Stormy Ruiz; Michelle D Colbert; Tiffany Luong; James E Crowe; Justin R Bailey; Pamela J Bjorkman. "HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design." Cell host & microbe (2018).

Epitope: HEPC74 Fab epitope
Chemical type: Discontinuous protein residues
Discontinuous residues: H251, L257, C259, N260, D261, S262, H264, T265, G266, F267, L268, A269, A270, F272, Y273, H275, K276, F277, N278, W359, E361
Source molecule (GenBank): AQV09138.1
Assay category: BCell
Result: Positive

Epitope: HEPC74 Fab epitope
Chemical type: Discontinuous protein residues
Discontinuous residues: H251, L257, C259, N260, D261, S262, H264, T265, G266, F267, L268, A269, A270, F272, Y273, H275, K276, F277, N278, W359, E361
Source molecule (GenBank): AQV09138.1
Assay category: BCell
Result: Positive

Epitope: HEPC74 Fab epitope
Chemical type: Discontinuous protein residues
Discontinuous residues: H251, L257, C259, N260, D261, S262, H264, T265, G266, F267, L268, A269, A270, F272, Y273, H275, K276, F277, N278, W359, E361
Source molecule (GenBank): AQV09138.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.99

Epitope: HEPC74 Fab epitope
Chemical type: Discontinuous protein residues
Discontinuous residues: H251, L257, C259, N260, D261, S262, H264, T265, G266, F267, L268, A269, A270, F272, Y273, H275, K276, F277, N278, W359, E361
Source molecule (GenBank): AQV09138.1
Assay category: BCell
Result: Positive

Epitope: HEPC74 Fab epitope
Chemical type: Discontinuous protein residues
Discontinuous residues: H251, L257, C259, N260, D261, S262, H264, T265, G266, F267, L268, A269, A270, F272, Y273, H275, K276, F277, N278, W359, E361
Source molecule (GenBank): AQV09138.1
Assay category: BCell
Result: Positive

Epitope: HEPC46 Fab epitope (HEPC3-E2core1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: V336, N362, T364, R365, P367, L368, G369, N370, W371, S417, R418, G456
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.1

Epitope: HEPC46 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: I294, S295, H296, V336, N362, N363, T364, R365, P367, L368, G369, N370, W371, P389, E413, S417, R418, G456
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8

Epitope: HEPC3 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: A229, K230, Q231, N232, L249, N250, C251, N252, D253, S254, L255, N256, T257, G258, W259, L260, A261, Y265, K268, F269, N270, W351, E353
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive

Epitope: HEPC3 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: A229, K230, Q231, N232, L249, N250, C251, N252, D253, S254, L255, N256, T257, G258, W259, L260, A261, Y265, K268, F269, N270, W351, E353
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive

Epitope: HEPC3 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: A229, K230, Q231, N232, L249, N250, C251, N252, D253, S254, L255, N256, T257, G258, W259, L260, A261, Y265, K268, F269, N270, W351, E353
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive

Epitope: HEPC3 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: A229, K230, Q231, N232, L249, N250, C251, N252, D253, S254, L255, N256, T257, G258, W259, L260, A261, Y265, K268, F269, N270, W351, E353
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive

Epitope: HEPC3 Fab epitope (HEPC3-E2ecto1a53-HEPC46)
Chemical type: Discontinuous protein residues
Discontinuous residues: A229, K230, Q231, N232, L249, N250, C251, N252, D253, S254, L255, N256, T257, G258, W259, L260, A261, Y265, K268, F269, N270, W351, E353
Source molecule (GenBank): AHV90282.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.8