Reference: Edurne Rujas; Hong Cui; Taylor Sicard; Anthony Semesi; Jean-Philippe Julien. "Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies." Nature communications (2020).

Epitope: Epitope of VNAR anti-ICOS-L on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: E58, R79, P105, Q106, E108, Q109, Y164, R166, T188, V189, F190, L191, M193, G195, Y197, D198
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.5

Epitope: Epitope of VNAR anti-ICOS-L on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: E58, R79, P105, Q106, E108, Q109, Y164, R166, T188, V189, F190, L191, M193, G195, Y197, D198
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.15

Epitope: Epitope of prezalumab on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, Q55, S59, K60, V62, Y65, Q69, S72, N75, V76, H112, L114, L116, Q118, F122, Q123, E124, S127
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.15

Epitope: Epitope of prezalumab on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, Q55, S59, K60, V62, Y65, Q69, S72, N75, V76, H112, L114, L116, Q118, F122, Q123, E124, S127
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive

Epitope: Epitope of prezalumab on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, Q55, S59, K60, V62, Y65, Q69, S72, N75, V76, H112, L114, L116, Q118, F122, Q123, E124, S127
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 5.5

Epitope: Epitope of prezalumab on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, Q55, S59, K60, V62, Y65, Q69, S72, N75, V76, H112, L114, L116, Q118, F122, Q123, E124, S127
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 820000.0

Epitope: Epitope of prezalumab on ICOS-L
Chemical type: Discontinuous protein residues
Discontinuous residues: Y53, Q55, S59, K60, V62, Y65, Q69, S72, N75, V76, H112, L114, L116, Q118, F122, Q123, E124, S127
Source molecule (GenBank): O75144.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0045

Epitope: Epitope of STIM003 Fab on ICOS
Chemical type: Discontinuous protein residues
Discontinuous residues: Q50, T66, T68, K69, G70, S71, S76, K78, F114, D115, P117, P118, F119
Source molecule (GenBank): Q9Y6W8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00072

Epitope: Epitope of STIM003 Fab on ICOS
Chemical type: Discontinuous protein residues
Discontinuous residues: Q50, T66, T68, K69, G70, S71, S76, K78, F114, D115, P117, P118, F119
Source molecule (GenBank): Q9Y6W8.1
Assay category: BCell
Result: Positive

Epitope: Epitope of STIM003 Fab on ICOS
Chemical type: Discontinuous protein residues
Discontinuous residues: Q50, T66, T68, K69, G70, S71, S76, K78, F114, D115, P117, P118, F119
Source molecule (GenBank): Q9Y6W8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.4

Epitope: Epitope of STIM003 Fab on ICOS
Chemical type: Discontinuous protein residues
Discontinuous residues: Q50, T66, T68, K69, G70, S71, S76, K78, F114, D115, P117, P118, F119
Source molecule (GenBank): Q9Y6W8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.0

Epitope: Epitope of STIM003 Fab on ICOS
Chemical type: Discontinuous protein residues
Discontinuous residues: Q50, T66, T68, K69, G70, S71, S76, K78, F114, D115, P117, P118, F119
Source molecule (GenBank): Q9Y6W8.1
Assay category: BCell
Result: Positive
Quantitative measurement: 300000.0

Epitope: Epitope of anti-kappa VHH
Chemical type: Discontinuous protein residues
Discontinuous residues: K108, T110, V111, E144, K146, T198, H199, Q200, G201, S203
Source molecule (GenBank): 7JOO_L
Assay category: BCell
Result: Positive
Quantitative measurement: 2.4