Reference: Marie Eliane Azoury; Fatoumata Samassa; Mijke Buitinga; Laura Nigi; Noemi Brusco; Aïsha Callebaut; Matthieu Giraud; Magali Irla; Ana Ines Lalanne; Alexia Carré; Georgia Afonso; Zhicheng Zhou; Barbara Brandao; Maikel L Colli; Guido Sebastiani; Francesco Dotta; Maki Nakayama; Decio L Eizirik; Sylvaine You; Sheena Pinto; Mark J Mamula; Yann Verdier; Joelle Vinh; Soren Buus; Chantal Mathieu; Lut Overbergh; Roberto Mallone. "CD8<sup>+</sup> T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes." Diabetes (2021).

Epitope: GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Negative
Cell type: other
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-Low
Cell type: other
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 9-18
Chemical type: Peptide from protein
Sequence: MLLLLSAARA
Position: 9-18
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 261-269
Chemical type: Peptide from protein
Sequence: RVMEHFIKL
Position: 261-269
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 298-307
Chemical type: Peptide from protein
Sequence: ALSSQHQARI
Position: 298-307
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 360-368
Chemical type: Peptide from protein
Sequence: VLVGGSTRI
Position: 360-368
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 435-443
Chemical type: Peptide from protein
Sequence: KLIPRNTVV
Position: 435-443
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-High

Epitope: cit GRP78 502-511
Chemical type: Peptide from protein
Sequence: EIDVNGILRV
Position: 502-511
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 502-511
Chemical type: Peptide from protein
Sequence: EIDVNGILRV
Position: 502-511
Source molecule (GenBank): P11021.2
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: cit GRP78 502-511
Chemical type: Peptide from protein
Sequence: EIDVNGILRV
Position: 502-511
Source molecule (GenBank): P11021.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: acetyl-CoA
Chemical type: Peptide from protein
Sequence: ALSSQHKARI
Position: 179-188
Source molecule (GenBank): HAP82565.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: acetyl-CoA
Chemical type: Peptide from protein
Sequence: ALSSQHKARI
Position: 179-188
Source molecule (GenBank): HAP82565.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DnaK chaperone
Chemical type: Peptide from protein
Sequence: DIDADGILHV
Position: 477-486
Source molecule (GenBank): AAC73125.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: DnaK chaperone
Chemical type: Peptide from protein
Sequence: DIDADGILHV
Position: 477-486
Source molecule (GenBank): AAC73125.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo