Reference: Yousra Hassainya; Francisco Garcia-Pons; Roland Kratzer; Vivian Lindo; Fiona Greer; François A Lemonnier; Gabriele Niedermann; Peter M van Endert. "Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology." Diabetes (2005).

Epitope: B9-B18
Chemical type: Peptide from protein
Sequence: SHLVEALYLV
Position: 33-42
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: B9-B18
Chemical type: Peptide from protein
Sequence: SHLVEALYLV
Position: 33-42
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: B9-B18
Chemical type: Peptide from protein
Sequence: SHLVEALYLV
Position: 33-42
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive

Epitope: B10-B18
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: B10-B18
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.0
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: B10-B18
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive

Epitope: B18-B27
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: B18-B27
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: C6-C14
Chemical type: Peptide from protein
Sequence: DLQVGQVEL
Position: 60-68
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C6-C14
Chemical type: Peptide from protein
Sequence: DLQVGQVEL
Position: 60-68
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: C22-C30
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 64-72
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C22-C30
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 64-72
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C22-C30
Chemical type: Peptide from protein
Sequence: SLQPLALEG
Position: 64-72
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: C27-C35
Chemical type: Peptide from protein
Sequence: ALEGSLQKR
Position: 69-77
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C27-C35
Chemical type: Peptide from protein
Sequence: ALEGSLQKR
Position: 69-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: C31-A5
Chemical type: Peptide from protein
Sequence: SLQKRGIVEQ
Position: 73-82
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C31-A5
Chemical type: Peptide from protein
Sequence: SLQKRGIVEQ
Position: 73-82
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: C31-A5
Chemical type: Peptide from protein
Sequence: SLQKRGIVEQ
Position: 73-82
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: A1-A10
Chemical type: Peptide from protein
Sequence: GIVEQCCTSI
Position: 78-87
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: A1-A10
Chemical type: Peptide from protein
Sequence: GIVEQCCTSI
Position: 78-87
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: A1-A10
Chemical type: Peptide from protein
Sequence: GIVEQCCTSI
Position: 78-87
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive

Epitope: A8-A16
Chemical type: Peptide from protein
Sequence: TSICSLYQL
Position: 85-93
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: A8-A16
Chemical type: Peptide from protein
Sequence: TSICSLYQL
Position: 85-93
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive

Epitope: A12-A20
Chemical type: Peptide from protein
Sequence: SLYQLENYC
Position: 89-97
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: A12-A20
Chemical type: Peptide from protein
Sequence: SLYQLENYC
Position: 89-97
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Short Term Restimulated

Epitope: A12-A20
Chemical type: Peptide from protein
Sequence: SLYQLENYC
Position: 89-97
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive