Reference: Sieglinde De Cae; Inge Van Molle; Loes van Schie; Sophie R Shoemaker; Julie Deckers; Nincy Debeuf; Sahine Lameire; Wim Nerinckx; Kenny Roose; Daria Fijalkowska; Simon Devos; Anne-Sophie De Smet; Jackeline Cecilia Zavala Marchan; Toon Venneman; Koen Sedeyn; Lejla Mujanovic; Marlies Ballegeer; Manon Vanheerswynghels; Caroline De Wolf; Hans Demol; Jasper Zuallaert; Pieter Vanhaverbeke; Gholamreza Hassanzadeh Ghassabeh; Chiara Lonigro; Viki Bockstal; Manuela Rinaldi; Rana Abdelnabi; Johan Neyts; Susan Marqusee; Bart N Lambrecht; Nico Callewaert; Han Remaut; Xavier Saelens; Bert Schepens. "Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base." Nature communications (2025).

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1300000.0

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.17

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.94

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00023

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH R3DC23 on SARS-CoV2 S-HR2
Chemical type: Region on multi-chain protein
Discontinuous residues: D: N1194, L1197, I1198, L1200, Q1201, G1204, K1205, Y1209, I1210, K1211; E: E1188, N1192, L1193, E1195, S1196, D1199, L1200, L1203, Y1206
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of hMab5.17
Chemical type: Peptide from protein
Sequence: DLGDISGIN
Position: 1165-1173
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of hMab5.17
Chemical type: Peptide from protein
Sequence: DLGDISGIN
Position: 1165-1173
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of hMab5.17
Chemical type: Peptide from protein
Sequence: DLGDISGIN
Position: 1165-1173
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive