Reference: Daichao Wu; Alexander Kolesnikov; Rui Yin; Johnathan D Guest; Ragul Gowthaman; Anton Shmelev; Yana Serdyuk; Dmitry V Dianov; Grigory A Efimov; Brian G Pierce; Roy A Mariuzza. "Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors." Nature communications (2022).

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.39

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 116000.0

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 1800.0

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.39

Epitope: YLQ
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.06

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 32900.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 170000.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.3

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 49000.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 9700.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 62800.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 50000.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 23000.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Quantitative measurement: 3400.0

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.81

Epitope: RLQ
Chemical type: Peptide from protein
Sequence: RLQSLQTYV
Position: 1000-1008
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.3

Epitope: SARS-CoV-2 variant P272L
Chemical type: Peptide from protein
Sequence: YLQLRTFLL
Position: 269-277
Source molecule (GenBank): QUA32500.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: SARS-CoV-2 variant P272L
Chemical type: Peptide from protein
Sequence: YLQLRTFLL
Position: 269-277
Source molecule (GenBank): QUA32500.1
Assay category: TCell
Result: Positive
Quantitative measurement: 116000.0