Reference: Paul-Albert Koenig; Hrishikesh Das; Hejun Liu; Beate M Kümmerer; Florian N Gohr; Lea-Marie Jenster; Lisa D J Schiffelers; Yonas M Tesfamariam; Miki Uchima; Jennifer D Wuerth; Karl Gatterdam; Natalia Ruetalo; Maria H Christensen; Caroline I Fandrey; Sabine Normann; Jan M P Tödtmann; Steffen Pritzl; Leo Hanke; Jannik Boos; Meng Yuan; Xueyong Zhu; Jonathan L Schmid-Burgk; Hiroki Kato; Michael Schindler; Ian A Wilson; Matthias Geyer; Kerstin U Ludwig; B Martin Hällberg; Nicholas C Wu; Florian I Schmidt. "Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape." Science (New York, N.Y.) (2021).

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.86
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.87
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 459000.0
Host: M 7 years

Epitope: Epitope of VHH E on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y351, K444, G446, Y449, N450, L452, T470, G485, F486, Y489, F490, L492, Q493, S494, G496, Q498
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000855
Host: M 7 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 339000.0
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00727
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.87
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 21.4
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH U on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, N437, V503, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 8.92
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 19300.0
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.55
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH V on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, C379, Y380, V382, P384, R408, Q414, N437, N439, N440, V503, Q506, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000172
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.73
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 677000.0
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.015
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 6 years

Epitope: Epitope of VHH W on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, N370, S371, A372, S373, F374, S375, T376, F377, K378, S383, P384, T385, R408, V503, G504, Y508
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 22.2
Host: M 6 years

Epitope: Epitope of CC12.3 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, F486, N487, Y489, Y495, G496, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.55
Host:  mean: 50 years

Epitope: Epitope of CC12.3 Fab on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, F486, N487, Y489, Y495, G496, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.73
Host:  mean: 50 years