Reference: Slobodan Culina; Ana Ines Lalanne; Georgia Afonso; Karen Cerosaletti; Sheena Pinto; Guido Sebastiani; Klaudia Kuranda; Laura Nigi; Anne Eugster; Thomas Østerbye; Alicia Maugein; James E McLaren; Kristin Ladell; Etienne Larger; Jean-Paul Beressi; Anna Lissina; Victor Appay; Howard W Davidson; Søren Buus; David A Price; Matthias Kuhn; Ezio Bonifacio; Manuela Battaglia; Sophie Caillat-Zucman; Francesco Dotta; Raphael Scharfmann; Bruno Kyewski; Roberto Mallone. "Islet-reactive CD8<sup>+</sup> T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors." Science immunology (2018).

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  8-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  9-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-High
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  10-15 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive-Low
Host:  11-27 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host: M 60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host: M 60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  24-42 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Host:  12-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 108.0

Epitope: ZnT8 186–194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 14.5

Epitope: MelanA26–35 A27L
Chemical type: Peptide, no natural source
Sequence: ELAGIGILTV
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: MelanA26–35 A27L
Chemical type: Peptide, no natural source
Sequence: ELAGIGILTV
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: MelanA26–35 A27L
Chemical type: Peptide, no natural source
Sequence: ELAGIGILTV
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: MelanA26–35 A27L
Chemical type: Peptide, no natural source
Sequence: ELAGIGILTV
Assay category: TCell
Result: Positive
Host:  8-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu MP 58–66
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): Q9IQ48.1
Assay category: TCell
Result: Positive
Host:  8-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu MP 58–66
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): Q9IQ48.1
Assay category: TCell
Result: Positive
Host:  11-27 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu MP 58–66
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): Q9IQ48.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 1224.0

Epitope: Flu MP 58–66
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): Q9IQ48.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 7.7

Epitope: PPI 15–24
Chemical type: Peptide from protein
Sequence: ALWGPDPAAA
Position: 15-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  8-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PPI 15–24
Chemical type: Peptide from protein
Sequence: ALWGPDPAAA
Position: 15-24
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive-Low
Host:  9-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GAD 114–122
Chemical type: Peptide from protein
Sequence: VMNILLQYV
Position: 114-122
Source molecule (GenBank): NP_000809.1
Assay category: TCell
Result: Positive
Host:  8-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GAD 114–122
Chemical type: Peptide from protein
Sequence: VMNILLQYV
Position: 114-122
Source molecule (GenBank): NP_000809.1
Assay category: TCell
Result: Positive
Host:  9-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 805–813
Chemical type: Peptide from protein
Sequence: VIVMLTPLV
Position: 805-813
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive
Host:  8-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 805–813
Chemical type: Peptide from protein
Sequence: VIVMLTPLV
Position: 805-813
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive
Host:  9-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IGRP 265–273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): NP_066999.1
Assay category: TCell
Result: Positive
Host:  8-62 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IGRP 265–273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): NP_066999.1
Assay category: TCell
Result: Positive
Host:  9-64 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: EboV NP 202–210
Chemical type: Peptide from protein
Sequence: RLMRTNFLI
Position: 101-109
Source molecule (GenBank): Q913A5.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HCV PP 1406–1415
Chemical type: Peptide from protein
Sequence: KLVALGINAV
Position: 1406-1415
Source molecule (GenBank): ANN11857.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: B. stercoris 151-159
Chemical type: Peptide from protein
Sequence: KAANIVLTV
Position: 151-159
Source molecule (GenBank): WP_060386636.1
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B. stercoris 151-159
Chemical type: Peptide from protein
Sequence: KAANIVLTV
Position: 151-159
Source molecule (GenBank): WP_060386636.1
Assay category: TCell
Result: Positive-Low
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B. stercoris 151-159
Chemical type: Peptide from protein
Sequence: KAANIVLTV
Position: 151-159
Source molecule (GenBank): WP_060386636.1
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B. stercoris 151-159
Chemical type: Peptide from protein
Sequence: KAANIVLTV
Position: 151-159
Source molecule (GenBank): WP_060386636.1
Assay category: TCell
Result: Positive
Host: F 34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B. stercoris 151-159
Chemical type: Peptide from protein
Sequence: KAANIVLTV
Position: 151-159
Source molecule (GenBank): WP_060386636.1
Assay category: TCell
Result: Positive
Host:  24-34 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ZnT8 185–194
Chemical type: Peptide from protein
Sequence: AVAANIVLTV
Position: 185-194
Source molecule (GenBank): Q8IWU4.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 138.0

Epitope: ZnT8 185–194
Chemical type: Peptide from protein
Sequence: AVAANIVLTV
Position: 185-194
Source molecule (GenBank): Q8IWU4.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 207.0