Reference: Anand Kumar; Cyril Planchais; Rémi Fronzes; Hugo Mouquet; Nicolas Reyes. "Binding mechanisms of therapeutic antibodies to human CD20." Science (New York, N.Y.) (2020).

Epitope: Epitope of rituximab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: I76, R156, P160, Y161, N166, E168, P169, A170, N171, P172, S173, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 7.7

Epitope: Epitope of rituximab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: I76, R156, P160, Y161, N166, E168, P169, A170, N171, P172, S173, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rituximab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: I76, R156, P160, Y161, N166, E168, P169, A170, N171, P172, S173, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive

Epitope: Epitope of rituximab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: I76, R156, P160, Y161, N166, E168, P169, A170, N171, P172, S173, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 450000.0

Epitope: Epitope of rituximab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: I76, R156, P160, Y161, N166, E168, P169, A170, N171, P172, S173, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0014

Epitope: Epitope of ofatumumab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: Y77, H145, Y161, N166, E168, A170, N171, P172, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 290000.0

Epitope: Epitope of ofatumumab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: Y77, H145, Y161, N166, E168, A170, N171, P172, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0045

Epitope: Epitope of ofatumumab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: Y77, H145, Y161, N166, E168, A170, N171, P172, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive

Epitope: Epitope of ofatumumab on CD20
Chemical type: Discontinuous protein residues
Discontinuous residues: Y77, H145, Y161, N166, E168, A170, N171, P172, E174, K175
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 43.0

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 410000.0

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0156

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive
Quantitative measurement: 47.0

Epitope: Epitope of obinutuzumab on CD20
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A170, N171, P172, S173, N176, S177; B: Y161, E174, S177, P178, S179
Source molecule (GenBank): P11836.1
Assay category: BCell
Result: Positive-Low