Reference: Brigitte Maurer; Ivan Bosanac; Steven Shia; Mandy Kwong; Racquel Corpuz; Richard Vandlen; Kerstin Schmidt; Charles Eigenbrot. "Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab." Protein science : a publication of the Protein Society (2015).

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.83

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 35.4

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.72

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.3

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 6.5

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.9

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.52

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.031

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.046

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.33

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.2

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.018

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2020000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000371

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00976

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0227

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000942

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000243

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00552

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 851000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 894000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 640000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 188000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1310000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 466000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000389

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000326

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 991000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000324

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 631000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000512

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1070000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000337

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1110000.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000162

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.0

Epitope: Epitope of rontalizumab on IFN-α2
Chemical type: Discontinuous protein residues
Discontinuous residues: A42, R45, I47, S48, L49, F50, L53, R56, H57, D58, G60, Q63, E64, R148, E164, R167, A168, M171, R172, S175, L176
Source molecule (GenBank): P01563.1
Assay category: BCell
Result: Positive
Quantitative measurement: 811000.0