Reference: Rujapak Sutiwisesak; Nathan D Hicks; Shayla Boyce; Kenan C Murphy; Kadamba Papavinasasundaram; Stephen M Carpenter; Julie Boucau; Neelambari Joshi; Sylvie Le Gall; Sarah M Fortune; Christopher M Sassetti; Samuel M Behar. "A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response." PLoS pathogens (2020).

Epitope: TB10 WT
Chemical type: Peptide from protein
Sequence: IMYNYPAM
Position: 4-11
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10 WT
Chemical type: Peptide from protein
Sequence: IMYNYPAM
Position: 4-11
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10 WT
Chemical type: Peptide from protein
Sequence: IMYNYPAM
Position: 4-11
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10 WT
Chemical type: Peptide from protein
Sequence: IMYNYPAM
Position: 4-11
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: TB10 WT
Chemical type: Peptide from protein
Sequence: IMYNYPAM
Position: 4-11
Source molecule (GenBank): P0A568.2
Assay category: MhcBinding
Result: Positive

Epitope: A10T
Chemical type: Peptide from protein
Sequence: IMYNYPTM
Position: 4-11
Source molecule (GenBank): WP_003908505.1
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: A10T
Chemical type: Peptide from protein
Sequence: IMYNYPTM
Position: 4-11
Source molecule (GenBank): WP_003908505.1
Assay category: TCell
Result: Positive-Intermediate
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: A10T
Chemical type: Peptide from protein
Sequence: IMYNYPTM
Position: 4-11
Source molecule (GenBank): WP_003908505.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: A10T
Chemical type: Peptide from protein
Sequence: IMYNYPTM
Position: 4-11
Source molecule (GenBank): WP_003908505.1
Assay category: MhcBinding
Result: Positive

Epitope: MTB32a 309-318
Chemical type: Peptide from protein
Sequence: GAPINSATAM
Position: 309-318
Source molecule (GenBank): AIH44220.1
Assay category: TCell
Result: Positive-Intermediate
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: MTB32a 309-318
Chemical type: Peptide from protein
Sequence: GAPINSATAM
Position: 309-318
Source molecule (GenBank): AIH44220.1
Assay category: TCell
Result: Positive-Low
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: ESAT6 1-15
Chemical type: Peptide from protein
Sequence: MTEQQWNFAGIEAAA
Position: 1-15
Source molecule (GenBank): P0A564.2
Assay category: TCell
Result: Positive
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: ESAT6 1-15
Chemical type: Peptide from protein
Sequence: MTEQQWNFAGIEAAA
Position: 1-15
Source molecule (GenBank): P0A564.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: M11I
Chemical type: Peptide from protein
Sequence: IMYNYPAI
Position: 4-11
Source molecule (GenBank): WP_070903075.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: M11I
Chemical type: Peptide from protein
Sequence: IMYNYPAI
Position: 4-11
Source molecule (GenBank): WP_070903075.1
Assay category: MhcBinding
Result: Positive

Epitope: A10V
Chemical type: Peptide from protein
Sequence: IMYNYPVM
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: A10V
Chemical type: Peptide from protein
Sequence: IMYNYPVM
Assay category: MhcBinding
Result: Positive

Epitope: P9S
Chemical type: Peptide from protein
Sequence: IMYNYSAM
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: lymphoid
Culture conditions: Cell Line / Clone

Epitope: P9S
Chemical type: Peptide from protein
Sequence: IMYNYSAM
Assay category: MhcBinding
Result: Positive

Epitope: TB10.4 20-28
Chemical type: Peptide from protein
Sequence: GYAGTLQSL
Position: 20-28
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-Intermediate
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 20-28
Chemical type: Peptide from protein
Sequence: GYAGTLQSL
Position: 20-28
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 20-28
Chemical type: Peptide from protein
Sequence: GYAGTLQSL
Position: 20-28
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 20-28
Chemical type: Peptide from protein
Sequence: GYAGTLQSL
Position: 20-28
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 74-88
Chemical type: Peptide from protein
Sequence: STHEANTMAMMARDT
Position: 74-88
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 74-88
Chemical type: Peptide from protein
Sequence: STHEANTMAMMARDT
Position: 74-88
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-High
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 74-88
Chemical type: Peptide from protein
Sequence: STHEANTMAMMARDT
Position: 74-88
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive-Intermediate
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4 74-88
Chemical type: Peptide from protein
Sequence: STHEANTMAMMARDT
Position: 74-88
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Positive
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:2
Chemical type: Peptide from protein
Sequence: MYNYPAMLGHAGDMA
Position: 5-19
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:2
Chemical type: Peptide from protein
Sequence: MYNYPAMLGHAGDMA
Position: 5-19
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:2
Chemical type: Peptide from protein
Sequence: MYNYPAMLGHAGDMA
Position: 5-19
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:3
Chemical type: Peptide from protein
Sequence: PAMLGHAGDMAGYAG
Position: 9-23
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:3
Chemical type: Peptide from protein
Sequence: PAMLGHAGDMAGYAG
Position: 9-23
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:3
Chemical type: Peptide from protein
Sequence: PAMLGHAGDMAGYAG
Position: 9-23
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:4
Chemical type: Peptide from protein
Sequence: GHAGDMAGYAGTLQS
Position: 13-27
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:4
Chemical type: Peptide from protein
Sequence: GHAGDMAGYAGTLQS
Position: 13-27
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:4
Chemical type: Peptide from protein
Sequence: GHAGDMAGYAGTLQS
Position: 13-27
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:7
Chemical type: Peptide from protein
Sequence: LQSLGAEIAVEQAAL
Position: 25-39
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:7
Chemical type: Peptide from protein
Sequence: LQSLGAEIAVEQAAL
Position: 25-39
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:7
Chemical type: Peptide from protein
Sequence: LQSLGAEIAVEQAAL
Position: 25-39
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:8
Chemical type: Peptide from protein
Sequence: GAEIAVEQAALQSAW
Position: 29-43
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:8
Chemical type: Peptide from protein
Sequence: GAEIAVEQAALQSAW
Position: 29-43
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:8
Chemical type: Peptide from protein
Sequence: GAEIAVEQAALQSAW
Position: 29-43
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:10
Chemical type: Peptide from protein
Sequence: AALQSAWQGDTGITY
Position: 37-51
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:10
Chemical type: Peptide from protein
Sequence: AALQSAWQGDTGITY
Position: 37-51
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:10
Chemical type: Peptide from protein
Sequence: AALQSAWQGDTGITY
Position: 37-51
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:11
Chemical type: Peptide from protein
Sequence: AWQGDTGITYQAWQ
Position: 42-55
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:11
Chemical type: Peptide from protein
Sequence: AWQGDTGITYQAWQ
Position: 42-55
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:11
Chemical type: Peptide from protein
Sequence: AWQGDTGITYQAWQ
Position: 42-55
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:12
Chemical type: Peptide from protein
Sequence: GDTGITYQAWQAQWN
Position: 45-59
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:12
Chemical type: Peptide from protein
Sequence: GDTGITYQAWQAQWN
Position: 45-59
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:12
Chemical type: Peptide from protein
Sequence: GDTGITYQAWQAQWN
Position: 45-59
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:13
Chemical type: Peptide from protein
Sequence: ITYQAWQAQWNQAME
Position: 49-63
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:13
Chemical type: Peptide from protein
Sequence: ITYQAWQAQWNQAME
Position: 49-63
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:13
Chemical type: Peptide from protein
Sequence: ITYQAWQAQWNQAME
Position: 49-63
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:14
Chemical type: Peptide from protein
Sequence: AWQAQWNQAMEDLVR
Position: 53-67
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:14
Chemical type: Peptide from protein
Sequence: AWQAQWNQAMEDLVR
Position: 53-67
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:14
Chemical type: Peptide from protein
Sequence: AWQAQWNQAMEDLVR
Position: 53-67
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:15
Chemical type: Peptide from protein
Sequence: QWNQAMEDLVRAYHA
Position: 57-71
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:15
Chemical type: Peptide from protein
Sequence: QWNQAMEDLVRAYHA
Position: 57-71
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:15
Chemical type: Peptide from protein
Sequence: QWNQAMEDLVRAYHA
Position: 57-71
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:16
Chemical type: Peptide from protein
Sequence: AMEDLVRAYHAMSST
Position: 61-75
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:16
Chemical type: Peptide from protein
Sequence: AMEDLVRAYHAMSST
Position: 61-75
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:16
Chemical type: Peptide from protein
Sequence: AMEDLVRAYHAMSST
Position: 61-75
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:17
Chemical type: Peptide from protein
Sequence: LVRAYHAMSSTHEAN
Position: 65-79
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:17
Chemical type: Peptide from protein
Sequence: LVRAYHAMSSTHEAN
Position: 65-79
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:17
Chemical type: Peptide from protein
Sequence: LVRAYHAMSSTHEAN
Position: 65-79
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:18
Chemical type: Peptide from protein
Sequence: YHAMSSTHEANTMAM
Position: 69-83
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:18
Chemical type: Peptide from protein
Sequence: YHAMSSTHEANTMAM
Position: 69-83
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:18
Chemical type: Peptide from protein
Sequence: YHAMSSTHEANTMAM
Position: 69-83
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:21
Chemical type: Peptide from protein
Sequence: MAMMARDTAEAAKWGG
Position: 81-96
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:21
Chemical type: Peptide from protein
Sequence: MAMMARDTAEAAKWGG
Position: 81-96
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD4+
Tissue: lung
Culture conditions: Direct Ex Vivo

Epitope: TB10.4:21
Chemical type: Peptide from protein
Sequence: MAMMARDTAEAAKWGG
Position: 81-96
Source molecule (GenBank): P0A568.2
Assay category: TCell
Result: Negative
Host: F 8-9 weeks
Cell type: T cell CD8+
Tissue: lung
Culture conditions: Direct Ex Vivo