Reference: Injin Bang; Takamitsu Hattori; Nadia Leloup; Alexis Corrado; Atekana Nyamaa; Akiko Koide; Ken Geles; Elizabeth Buck; Shohei Koide. "Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain." Nature chemical biology (2025).

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.215

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.315

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0011

Epitope: Epitope of Fab TL1 on HER2 S310F
Chemical type: Discontinuous protein residues
Discontinuous residues: T27, Q57, Q81, T105, Q106, F258, H267, T290, F291, G292, Y303, T306, D307, V308, C311, T312, L313, V314, P316, L317, H318, K333, C334, S335, K336, P337, Y343, E348, H349, R351, E352, R434, L436, G439
Source molecule (GenBank): P04626.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0012