Reference: Nicholas K Hurlburt; Leah J Homad; Irika Sinha; Madeleine F Jennewein; Anna J MacCamy; Yu-Hsin Wan; Jim Boonyaratanakornkit; Anton M Sholukh; Abigail M Jackson; Panpan Zhou; Dennis R Burton; Raiees Andrabi; Gabriel Ozorowski; Andrew B Ward; Leonidas Stamatatos; Marie Pancera; Andrew T McGuire. "Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit." Communications biology (2022).

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000389
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 591000.0
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000159
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 30000.0
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.74
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 23000.0
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 0.000676
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 0.000613
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 17000.0
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 30.98
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Quantitative measurement: 39.33
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 20.4
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 0.000669
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 33000.0
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.23
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.66
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV3-25
Chemical type: Peptide from protein
Sequence: DKYFKNHTSPDVDL
Position: 1153-1166
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: Epitope of mAb CV30
Chemical type: Discontinuous protein residues
Discontinuous residues: T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, S459, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, S494, Y495, G496, Q498, T500, N501, G502, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host: M 35 years

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-High
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-High
Host: F 10 weeks

Epitope: Epitope of mAb B6
Chemical type: Peptide from protein
Sequence: SFKEELDKYFK
Position: 1147-1157
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: F 10 weeks

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb CC40.8
Chemical type: Peptide from protein
Sequence: QPELDSFKEELDKYFKNH
Position: 1142-1159
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate
Host: M 35 years

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Host: M 35 years

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low
Host: M 35 years

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years

Epitope: stem helix
Chemical type: Peptide from protein
Sequence: LDSFKEELDKYFKNHTSPDVDLG
Position: 1145-1167
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Host: M 35 years