Reference: Agnieszka K Grabowska; Andreas M Kaufmann; Angelika B Riemer. "Identification of promiscuous HPV16-derived T helper cell epitopes for therapeutic HPV vaccine design." International journal of cancer. Journal international du cancer (2015).

Epitope: E6/16-30
Chemical type: Peptide from protein
Sequence: PRKLPQLCTELQTTI
Position: 16-30
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/42-56
Chemical type: Peptide from protein
Sequence: QQLLRREVYDFAFRD
Position: 42-56
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/54-68
Chemical type: Peptide from protein
Sequence: FRDLCIVYRDGNPYA
Position: 54-68
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 336 353 340 430 333 406 407
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/74-88
Chemical type: Peptide from protein
Sequence: LKFYSKISEYRHYCY
Position: 74-88
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/92-106
Chemical type: Peptide from protein
Sequence: GTTLEQQYNKPLCDL
Position: 92-106
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E6/129-143
Chemical type: Peptide from protein
Sequence: KQRFHNIRGRWTGRC
Position: 129-143
Source molecule (GenBank): AAD33252.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 336 353 340 430 333 406 407
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/12-26
Chemical type: Peptide from protein
Sequence: MLDLQPETTDLYCYE
Position: 12-26
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/63-77
Chemical type: Peptide from protein
Sequence: STLRLCVQSTHVDIR
Position: 63-77
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 336 353 340 430 333 406 407
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/64-78
Chemical type: Peptide from protein
Sequence: TLRLCVQSTHVDIRT
Position: 64-78
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/71-85
Chemical type: Peptide from protein
Sequence: STHVDIRTLEDLLMG
Position: 71-85
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E7/76-90
Chemical type: Peptide from protein
Sequence: IRTLEDLLMGTLGIV
Position: 76-90
Source molecule (GenBank): AAD33253.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 340 327 352 333 330 336 430 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/27-42
Chemical type: Peptide from protein
Sequence: RDHIDYWKHMRLECA
Position: 27-41
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/51-65
Chemical type: Peptide from protein
Sequence: FKHINHQVVPTLAVS
Position: 51-65
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/59-73
Chemical type: Peptide from protein
Sequence: VPTLAVSKNKALQAI
Position: 59-73
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/76-90
Chemical type: Peptide from protein
Sequence: QLTLETIYNSQYSNE
Position: 76-90
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/99-113
Chemical type: Peptide from protein
Sequence: LEVYLTAPTGCIKKH
Position: 99-113
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 336 353 340 430 333 406 407
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/156-170
Chemical type: Peptide from protein
Sequence: GLYYVHEGIRTYFVQ
Position: 156-170
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/208-223
Chemical type: Peptide from protein
Sequence: PEIIRQHLANHPAAT
Position: 208-222
Source molecule (GenBank): P03120.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/267-282
Chemical type: Peptide from protein
Sequence: ILTAFNSSHKGRINC
Position: 267-281
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/288-302
Chemical type: Peptide from protein
Sequence: IVHLKGDANTLKCLR
Position: 288-302
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/300-314
Chemical type: Peptide from protein
Sequence: CLRYRFKKHCTLYTA
Position: 300-314
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2/344-359
Chemical type: Peptide from protein
Sequence: DQFLSQVKIPKTITV
Position: 344-358
Source molecule (GenBank): AAD33255.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/1-15
Chemical type: Peptide from protein
Sequence: MTNLDTASTTLLACF
Position: 1-15
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/30-45
Chemical type: Peptide from protein
Sequence: RPLLLSVSTYTSLIL
Position: 30-44
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 336 353 340 430 333 406 407
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/33-48
Chemical type: Peptide from protein
Sequence: LLSVSTYTSLILLVL
Position: 33-47
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Negative
MHC allele types: 333 330
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/45-60
Chemical type: Peptide from protein
Sequence: LVLVLWITAASAFRC
Position: 45-59
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/54-69
Chemical type: Peptide from protein
Sequence: ASAFRCFIVYIVFVY
Position: 54-68
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/60-74
Chemical type: Peptide from protein
Sequence: FIVYIVFVYIPLFLI
Position: 60-74
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/67-81
Chemical type: Peptide from protein
Sequence: VYIPLFLIHTHARFL
Position: 67-81
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E5/69-84
Chemical type: Peptide from protein
Sequence: IPLFLIHTHARFLIT
Position: 69-83
Source molecule (GenBank): AAO85413.1
Assay category: TCell
Result: Positive
MHC allele types: 350 341 330 353 340 327 333 336 423 355
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo