Reference: Emmi-Leena Ihantola; Henna Ilmonen; Anssi Kailaanmäki; Marja Rytkönen-Nissinen; Aurélien Azam; Bernard Maillère; Cecilia S Lindestam Arlehamn; Alessandro Sette; Keshav Motwani; Howard R Seay; Todd M Brusko; Mikael Knip; Riitta Veijola; Jorma Toppari; Jorma Ilonen; Tuure Kinnunen. "Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules." Journal of immunology (Baltimore, Md. : 1950) (2020).

Epitope: B8-22
Chemical type: Peptide from protein
Sequence: GSHLVEALYLVCGER
Position: 32-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: B8-22
Chemical type: Peptide from protein
Sequence: GSHLVEALYLVCGER
Position: 32-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: B8-22
Chemical type: Peptide from protein
Sequence: GSHLVEALYLVCGER
Position: 32-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B8-22
Chemical type: Peptide from protein
Sequence: GSHLVEALYLVCGER
Position: 32-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: B8-22
Chemical type: Peptide from protein
Sequence: GSHLVEALYLVCGER
Position: 32-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 730.0

Epitope: B11-25
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFF
Position: 35-49
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: B11-25
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFF
Position: 35-49
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 9990.0

Epitope: B11-25
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFF
Position: 35-49
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B11-25
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFF
Position: 35-49
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 21000.0

Epitope: B11-25
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFF
Position: 35-49
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 730.0

Epitope: B14-28
Chemical type: Peptide from protein
Sequence: ALYLVCGERGFFYTP
Position: 38-52
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 75000.0

Epitope: B14-28
Chemical type: Peptide from protein
Sequence: ALYLVCGERGFFYTP
Position: 38-52
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 80010.0

Epitope: B14-28
Chemical type: Peptide from protein
Sequence: ALYLVCGERGFFYTP
Position: 38-52
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B14-28
Chemical type: Peptide from protein
Sequence: ALYLVCGERGFFYTP
Position: 38-52
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: B14-28
Chemical type: Peptide from protein
Sequence: ALYLVCGERGFFYTP
Position: 38-52
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 44530.0

Epitope: B17-C1
Chemical type: Peptide from protein
Sequence: LVCGERGFFYTPKTR
Position: 41-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: B17-C1
Chemical type: Peptide from protein
Sequence: LVCGERGFFYTPKTR
Position: 41-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: B17-C1
Chemical type: Peptide from protein
Sequence: LVCGERGFFYTPKTR
Position: 41-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B17-C1
Chemical type: Peptide from protein
Sequence: LVCGERGFFYTPKTR
Position: 41-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: B17-C1
Chemical type: Peptide from protein
Sequence: LVCGERGFFYTPKTR
Position: 41-55
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: B20-C4
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 450.0

Epitope: B20-C4
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: B20-C4
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B20-C4
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: B20-C4
Chemical type: Peptide from protein
Sequence: GERGFFYTPKTRREA
Position: 44-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: C10-24
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: C10-24
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: C10-24
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: C10-24
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: C10-24
Chemical type: Peptide from protein
Sequence: GQVELGGGPGAGSLQ
Position: 64-78
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: C13-27
Chemical type: Peptide from protein
Sequence: ELGGGPGAGSLQPLA
Position: 67-81
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: C13-27
Chemical type: Peptide from protein
Sequence: ELGGGPGAGSLQPLA
Position: 67-81
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: C13-27
Chemical type: Peptide from protein
Sequence: ELGGGPGAGSLQPLA
Position: 67-81
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: C13-27
Chemical type: Peptide from protein
Sequence: ELGGGPGAGSLQPLA
Position: 67-81
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: C13-27
Chemical type: Peptide from protein
Sequence: ELGGGPGAGSLQPLA
Position: 67-81
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: C16-30
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPLALEG
Position: 70-84
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: C16-30
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPLALEG
Position: 70-84
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: C16-30
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPLALEG
Position: 70-84
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: C16-30
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPLALEG
Position: 70-84
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: C16-30
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPLALEG
Position: 70-84
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: C19-33
Chemical type: Peptide from protein
Sequence: GAGSLQPLALEGSLQ
Position: 73-87
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 35770.0

Epitope: C19-33
Chemical type: Peptide from protein
Sequence: GAGSLQPLALEGSLQ
Position: 73-87
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: C19-33
Chemical type: Peptide from protein
Sequence: GAGSLQPLALEGSLQ
Position: 73-87
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 52920.0

Epitope: C19-33
Chemical type: Peptide from protein
Sequence: GAGSLQPLALEGSLQ
Position: 73-87
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 8883.0

Epitope: C19-33
Chemical type: Peptide from protein
Sequence: GAGSLQPLALEGSLQ
Position: 73-87
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 21000.0

Epitope: C25-A4
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 93750.0

Epitope: C25-A4
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 4590.0

Epitope: C25-A4
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: C25-A4
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 70000.0

Epitope: C25-A4
Chemical type: Peptide from protein
Sequence: PLALEGSLQKRGIVE
Position: 79-93
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 104390.0

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 7000.0

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 6570.0

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 7950.0

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 99990.0

Epitope: A1-15
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLYQ
Position: 90-104
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 63000.0

Epitope: B14-23
Chemical type: Peptide from protein
Sequence: ALYLVCGERG
Position: 38-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C16-26
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPL
Position: 70-80
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C16-26
Chemical type: Peptide from protein
Sequence: GGPGAGSLQPL
Position: 70-80
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: A1-14
Chemical type: Peptide from protein
Sequence: GIVEQCCTSICSLY
Position: 90-103
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C21-32
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSL
Position: 75-86
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C21-32
Chemical type: Peptide from protein
Sequence: GSLQPLALEGSL
Position: 75-86
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B10-20
Chemical type: Peptide from protein
Sequence: HLVEALYLVCG
Position: 34-44
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C18-28
Chemical type: Peptide from protein
Sequence: PGAGSLQPLAL
Position: 72-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C18-28
Chemical type: Peptide from protein
Sequence: PGAGSLQPLAL
Position: 72-82
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C25-33
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 79-87
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C25-34
Chemical type: Peptide from protein
Sequence: PLALEGSLQK
Position: 79-88
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C25-35
Chemical type: Peptide from protein
Sequence: PLALEGSLQKR
Position: 79-89
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C24-35
Chemical type: Peptide from protein
Sequence: QPLALEGSLQKR
Position: 78-89
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B22-C3
Chemical type: Peptide from protein
Sequence: RGFFYTPKTRRE
Position: 46-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B9-18
Chemical type: Peptide from protein
Sequence: SHLVEALYLV
Position: 33-42
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C22-32
Chemical type: Peptide from protein
Sequence: SLQPLALEGSL
Position: 76-86
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C22-33
Chemical type: Peptide from protein
Sequence: SLQPLALEGSLQ
Position: 76-87
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: C22-33
Chemical type: Peptide from protein
Sequence: SLQPLALEGSLQ
Position: 76-87
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B18-26
Chemical type: Peptide from protein
Sequence: VCGERGFFY
Position: 42-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B18-26
Chemical type: Peptide from protein
Sequence: VCGERGFFY
Position: 42-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B16-24
Chemical type: Peptide from protein
Sequence: YLVCGERGF
Position: 40-48
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B16-25
Chemical type: Peptide from protein
Sequence: YLVCGERGFF
Position: 40-49
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B16-27
Chemical type: Peptide from protein
Sequence: YLVCGERGFFYT
Position: 40-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: B9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVCGERG
Position: 33-47
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  child
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone