Reference: Lidia Cerdán; Katixa Silva; Daniel Rodríguez-Martín; Patricia Pérez; María A Noriega; Ana Esteban Martín; Alfonso Gutiérrez-Adán; Yago Margolles; Juan A Corbera; Miguel A Martín-Acebes; Juan García-Arriaza; Juan Fernández-Recio; Luis A Fernández; José M Casasnovas. "Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants." mAbs (2025).

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.56

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.3

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.21

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.14

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.4

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.41

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 16.95

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.57

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.53

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.54

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.25

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 165000.0

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000241

Epitope: Epitope of nanoboby Nb4 on SARS-CoV-2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, A348, S349, Y351, W353, N354, R355, G446, G447, Y449, N450, L452, R466, I468, T470, I472, G482, V483, E484, F490, L492, Q493, S494
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive