Reference: Morgane Lopez; Laurie Spehner; Fabrice André; Julien Viot; Evan Seffar; Amélie Marguier; Elsa Curtit; Guillaume Meynard; Erion Dobi; Sylvain Ladoire; Romain Boidot; Romain Loyon; Valentin Derangere; François-Clément Bidard; Christophe Borg; Laura Mansi; Marie Kroemer. "Exploring the role of ESR1 mutations in metastatic hormone receptor-positive breast cancer T cell immune surveillance disruption." Breast cancer research : BCR (2025).

Epitope: P0
Chemical type: Peptide from protein
Sequence: PLYDLLLEM
Position: 535-543
Source molecule (GenBank): P03372.2
Assay category: TCell
Result: Positive-Low
Cell type: T cell
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P0
Chemical type: Peptide from protein
Sequence: PLYDLLLEM
Position: 535-543
Source molecule (GenBank): P03372.2
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P0
Chemical type: Peptide from protein
Sequence: PLYDLLLEM
Position: 535-543
Source molecule (GenBank): P03372.2
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P0
Chemical type: Peptide from protein
Sequence: PLYDLLLEM
Position: 535-543
Source molecule (GenBank): P03372.2
Assay category: MhcBinding
Result: Positive

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive-Low
Cell type: T cell
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P1
Chemical type: Peptide, no natural source
Sequence: VPLYGLLLEM
Assay category: MhcBinding
Result: Positive

Epitope: P2
Chemical type: Peptide, no natural source
Sequence: NVVPLYGLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2
Chemical type: Peptide, no natural source
Sequence: NVVPLYGLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P2
Chemical type: Peptide, no natural source
Sequence: NVVPLYGLL
Assay category: MhcBinding
Result: Negative

Epitope: P3
Chemical type: Peptide, no natural source
Sequence: VVPLYGLLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P3
Chemical type: Peptide, no natural source
Sequence: VVPLYGLLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P3
Chemical type: Peptide, no natural source
Sequence: VVPLYGLLL
Assay category: MhcBinding
Result: Negative

Epitope: P4
Chemical type: Peptide, no natural source
Sequence: PLYGLLLEM
Assay category: TCell
Result: Positive-Low
Cell type: T cell
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P4
Chemical type: Peptide, no natural source
Sequence: PLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P4
Chemical type: Peptide, no natural source
Sequence: PLYGLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P4
Chemical type: Peptide, no natural source
Sequence: PLYGLLLEM
Assay category: MhcBinding
Result: Positive

Epitope: P5
Chemical type: Peptide, no natural source
Sequence: LYGLLLEML
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P5
Chemical type: Peptide, no natural source
Sequence: LYGLLLEML
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P5
Chemical type: Peptide, no natural source
Sequence: LYGLLLEML
Assay category: MhcBinding
Result: Positive

Epitope: P7
Chemical type: Peptide, no natural source
Sequence: NVVPLSDLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P7
Chemical type: Peptide, no natural source
Sequence: NVVPLSDLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P7
Chemical type: Peptide, no natural source
Sequence: NVVPLSDLL
Assay category: MhcBinding
Result: Negative

Epitope: P8
Chemical type: Peptide, no natural source
Sequence: KNVVPLSDL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P8
Chemical type: Peptide, no natural source
Sequence: KNVVPLSDL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P8
Chemical type: Peptide, no natural source
Sequence: KNVVPLSDL
Assay category: MhcBinding
Result: Negative

Epitope: P9
Chemical type: Peptide, no natural source
Sequence: VPLSDLLLE
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P9
Chemical type: Peptide, no natural source
Sequence: VPLSDLLLE
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P9
Chemical type: Peptide, no natural source
Sequence: VPLSDLLLE
Assay category: MhcBinding
Result: Negative

Epitope: P10
Chemical type: Peptide, no natural source
Sequence: PLSDLLLEM
Assay category: TCell
Result: Positive-Low
Cell type: T cell
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P10
Chemical type: Peptide, no natural source
Sequence: PLSDLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P10
Chemical type: Peptide, no natural source
Sequence: PLSDLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P10
Chemical type: Peptide, no natural source
Sequence: PLSDLLLEM
Assay category: MhcBinding
Result: Positive

Epitope: P11
Chemical type: Peptide, no natural source
Sequence: LSDLLLEML
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P11
Chemical type: Peptide, no natural source
Sequence: LSDLLLEML
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P11
Chemical type: Peptide, no natural source
Sequence: LSDLLLEML
Assay category: MhcBinding
Result: Negative

Epitope: P12
Chemical type: Peptide, no natural source
Sequence: VVPLSDLLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P12
Chemical type: Peptide, no natural source
Sequence: VVPLSDLLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P12
Chemical type: Peptide, no natural source
Sequence: VVPLSDLLL
Assay category: MhcBinding
Result: Negative

Epitope: P13
Chemical type: Peptide, no natural source
Sequence: NVVPLNDLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P13
Chemical type: Peptide, no natural source
Sequence: NVVPLNDLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P13
Chemical type: Peptide, no natural source
Sequence: NVVPLNDLL
Assay category: MhcBinding
Result: Negative

Epitope: P14
Chemical type: Peptide, no natural source
Sequence: PLNDLLLEM
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P14
Chemical type: Peptide, no natural source
Sequence: PLNDLLLEM
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P14
Chemical type: Peptide, no natural source
Sequence: PLNDLLLEM
Assay category: MhcBinding
Result: Negative

Epitope: P15
Chemical type: Peptide, no natural source
Sequence: VPLNDLLLE
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P15
Chemical type: Peptide, no natural source
Sequence: VPLNDLLLE
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P15
Chemical type: Peptide, no natural source
Sequence: VPLNDLLLE
Assay category: MhcBinding
Result: Negative

Epitope: P16
Chemical type: Peptide, no natural source
Sequence: KNVVPLNDL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P16
Chemical type: Peptide, no natural source
Sequence: KNVVPLNDL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P16
Chemical type: Peptide, no natural source
Sequence: KNVVPLNDL
Assay category: MhcBinding
Result: Negative

Epitope: P17
Chemical type: Peptide, no natural source
Sequence: KNVVPLCDL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P17
Chemical type: Peptide, no natural source
Sequence: KNVVPLCDL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P17
Chemical type: Peptide, no natural source
Sequence: KNVVPLCDL
Assay category: MhcBinding
Result: Negative

Epitope: P18
Chemical type: Peptide, no natural source
Sequence: VVPLCDLLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P18
Chemical type: Peptide, no natural source
Sequence: VVPLCDLLL
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P18
Chemical type: Peptide, no natural source
Sequence: VVPLCDLLL
Assay category: MhcBinding
Result: Negative

Epitope: P19
Chemical type: Peptide, no natural source
Sequence: LCDLLLEML
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P19
Chemical type: Peptide, no natural source
Sequence: LCDLLLEML
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P19
Chemical type: Peptide, no natural source
Sequence: LCDLLLEML
Assay category: MhcBinding
Result: Positive

Epitope: P20
Chemical type: Peptide, no natural source
Sequence: PLCDLLLEM
Assay category: TCell
Result: Positive-High
Cell type: T cell
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P20
Chemical type: Peptide, no natural source
Sequence: PLCDLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P20
Chemical type: Peptide, no natural source
Sequence: PLCDLLLEM
Assay category: TCell
Result: Positive
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P20
Chemical type: Peptide, no natural source
Sequence: PLCDLLLEM
Assay category: MhcBinding
Result: Negative

Epitope: P21
Chemical type: Peptide, no natural source
Sequence: NVVPLCDLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P21
Chemical type: Peptide, no natural source
Sequence: NVVPLCDLL
Assay category: TCell
Result: Negative
Host: F 
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: P21
Chemical type: Peptide, no natural source
Sequence: NVVPLCDLL
Assay category: MhcBinding
Result: Negative