Reference: Helen M E Duyvesteyn; Aiste Dijokaite-Guraliuc; Chang Liu; Piyada Supasa; Barbara Kronsteiner; Katie Jeffery; Lizzie Stafford; Paul Klenerman; Susanna J Dunachie; Juthathip Mongkolsapaya; Elizabeth E Fry; Jingshan Ren; David I Stuart; Gavin R Screaton. "Concerted deletions eliminate a neutralizing supersite in SARS-CoV-2 BA.2.87.1 spike." Structure (London, England : 1993) (2024).

Epitope: Epitope of mAb XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb SD1-1 on BA.4/5 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N527, L528, K530, N531, K532, E549, N551, Q575, T576, L577, E578
Source molecule (GenBank): UPP14409.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb SD1-2 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: N532, L533, V534, K535, N536, K537, E554, S555, N556, Q580, T581, L582, E583
Source molecule (GenBank): UOL34873.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb SD1-3 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: K535, E554, S555, N556, K557, K558, F559, P561, R577, T581, L582, E583, I584
Source molecule (GenBank): UOL34873.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of mAb AZD8895 on SARS-CoV2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: L455, A475, G476, S477, T478, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-High