Reference: Xiao-Yan Zhao; Andreas Wilmen; Dongli Wang; Xinquan Wang; Maxine Bauzon; Ji-Yun Kim; Lars Linden; Liang Li; Ursula Egner; Tobias Marquardt; Dieter Moosmayer; Jan Tebbe; Julian Marius Glück; Philipp Ellinger; Kirk McLean; Shujun Yuan; Subramanian Yegneswaran; Xiaoqiao Jiang; Vince Evans; Jian-Ming Gu; Doug Schneider; Ying Zhu; Yifan Xu; Cornell Mallari; Ashley Hesslein; Yan Wang; Nicole Schmidt; Katrin Gutberlet; Christine Ruehl-Fehlert; Alexius Freyberger; Terry Hermiston; Chandra Patel; Derek Sim; Laurent O Mosnier; Volker Laux. "Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia." Nature communications (2020).

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 13.0

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 150000.0

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0019

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of C25K23 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: D256, K293, S294, T295, T296, S374, E375, V376, M377, S378, N379, M380, A397, C398, E399, S195, V420, S421, W422, G423, E424, G425
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.2

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.7

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 610000.0

Epitope: Epitope of h1573 Fab on APC
Chemical type: Discontinuous protein residues
Discontinuous residues: Y344, S346, S347, R348, E349, K350, E351, R394, C398, E399, E424, G425, C426, L428, L429, H430
Source molecule (GenBank): P04070.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0062