Reference: Heather B Streeter; Lora G Lucas; Robert M West; Mamidipudi T Krishna; David C Wraith. "A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice." Frontiers in immunology (2025).

Epitope: Peptide A
Chemical type: Peptide from protein
Sequence: NGNAPAEIDLRQMRTVTPIRMQGGCGSCWA
Position: 105-134
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide A
Chemical type: Peptide from protein
Sequence: NGNAPAEIDLRQMRTVTPIRMQGGCGSCWA
Position: 105-134
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide B
Chemical type: Peptide from protein
Sequence: PRGIEYIQHNGVVQESYYRYVAREQSCRRP
Position: 175-204
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide B
Chemical type: Peptide from protein
Sequence: PRGIEYIQHNGVVQESYYRYVAREQSCRRP
Position: 175-204
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide B
Chemical type: Peptide from protein
Sequence: PRGIEYIQHNGVVQESYYRYVAREQSCRRP
Position: 175-204
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide C
Chemical type: Peptide from protein
Sequence: KIREALAQTHSAIAVIIGIKDLDAFRHYDG
Position: 224-253
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide C
Chemical type: Peptide from protein
Sequence: KIREALAQTHSAIAVIIGIKDLDAFRHYDG
Position: 224-253
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide C
Chemical type: Peptide from protein
Sequence: KIREALAQTHSAIAVIIGIKDLDAFRHYDG
Position: 224-253
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 63 750
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: T cell
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 63 750
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide D
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFRHYDGRTIIQRDNGYQ
Position: 235-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Peptide E
Chemical type: Peptide from protein
Sequence: PNYHAVNIVGYSNAQGVDYWIVRNSWDTN
Position: 265-293
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Peptide E
Chemical type: Peptide from protein
Sequence: PNYHAVNIVGYSNAQGVDYWIVRNSWDTN
Position: 265-293
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: D1
Chemical type: Peptide from protein
Sequence: AIAVIIGIKDLDAFR
Position: 235-249
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D2
Chemical type: Peptide from protein
Sequence: VIIGIKDLDAFRHYD
Position: 238-252
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D3
Chemical type: Peptide from protein
Sequence: GIKDLDAFRHYDGRT
Position: 241-255
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D4
Chemical type: Peptide from protein
Sequence: DLDAFRHYDGRTIIQ
Position: 244-258
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D5
Chemical type: Peptide from protein
Sequence: AFRHYDGRTIIQRDN
Position: 247-261
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D6
Chemical type: Peptide from protein
Sequence: HYDGRTIIQRDNGYQ
Position: 250-264
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D11
Chemical type: Peptide from protein
Sequence: AVIIGIKDLDAFRHY
Position: 237-251
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D111
Chemical type: Peptide from protein
Sequence: AVIIGIKDLDAFRHY
Position: 237-251
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D112
Chemical type: Peptide from protein
Sequence: VIIGIKDLDAFRH
Position: 238-250
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D113
Chemical type: Peptide from protein
Sequence: IIGIKDLDAFRH
Position: 239-250
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D114
Chemical type: Peptide from protein
Sequence: IGIKDLDAFRH
Position: 240-250
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D121
Chemical type: Peptide from protein
Sequence: IAVIIGIKDLDAFRH
Position: 236-250
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D123
Chemical type: Peptide from protein
Sequence: IAVIIGIKDLDAF
Position: 236-248
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D124
Chemical type: Peptide from protein
Sequence: IAVIIGIKDLDA
Position: 236-247
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D125
Chemical type: Peptide from protein
Sequence: IAVIIGIKDLD
Position: 236-246
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D126
Chemical type: Peptide from protein
Sequence: IAVIIGIKDL
Position: 236-245
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D21B
Chemical type: Peptide from protein
Sequence: IIGIKDLDAFRHYDG
Position: 239-253
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D21C
Chemical type: Peptide from protein
Sequence: IGIKDLDAFRHYDGR
Position: 240-254
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D111B
Chemical type: Peptide, no natural source
Sequence: RRKIAVIIGIKDLDAFRKRR
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: T cell
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: D111B
Chemical type: Peptide, no natural source
Sequence: RRKIAVIIGIKDLDAFRKRR
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: D111B
Chemical type: Peptide, no natural source
Sequence: RRKIAVIIGIKDLDAFRKRR
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: B1
Chemical type: Peptide from protein
Sequence: PRGIEYIQHNGVVQE
Position: 175-189
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: B2
Chemical type: Peptide from protein
Sequence: IEYIQHNGVVQESYY
Position: 178-192
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: B4
Chemical type: Peptide from protein
Sequence: NGVVQESYYRYVAR
Position: 184-197
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: B5
Chemical type: Peptide from protein
Sequence: VQESYYRYVAREQSC
Position: 187-201
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: B6
Chemical type: Peptide from protein
Sequence: ESYYRYVAREQSCRRP
Position: 189-204
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: IGIKDLD
Chemical type: Peptide from protein
Sequence: IGIKDLD
Position: 240-246
Source molecule (GenBank): P08176.2
Assay category: TCell
Result: Positive
MHC allele types: 47
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo