Reference: Amarendra Pegu; Zhi-yong Yang; Jeffrey C Boyington; Lan Wu; Sung-Youl Ko; Stephen D Schmidt; Krisha McKee; Wing-Pui Kong; Wei Shi; Xuejun Chen; John-Paul Todd; Norman L Letvin; Jinghe Huang; Martha C Nason; James A Hoxie; Peter D Kwong; Mark Connors; Srinivas S Rao; John R Mascola; Gary J Nabel. "Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor." Science translational medicine (2014).

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Negative

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.65

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 2D5 on CD4
Chemical type: Discontinuous protein residues
Discontinuous residues: H52, K54, S56, N57, Q58, I59, K60, K71, G72, P73, S74, K75, N77, D78, R79, E102, I108, K115
Source molecule (GenBank): P01730.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb VRC01 on HIV-1 gp120
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, L121, N272, S274, D275, N276, A277, K278, S358, G359, G360, D361, I364, V421, G422, Q423, T446, R447, D448, G449, G450, N451, T452, N459, E460, T461, R463, R470
Source molecule (GenBank): Q3ZLH8.1
Assay category: BCell
Result: Positive
Host: M 56 years

Epitope: Epitope of mAb VRC01 on HIV-1 gp120
Chemical type: Discontinuous protein residues
Discontinuous residues: K96, L121, N272, S274, D275, N276, A277, K278, S358, G359, G360, D361, I364, V421, G422, Q423, T446, R447, D448, G449, G450, N451, T452, N459, E460, T461, R463, R470
Source molecule (GenBank): Q3ZLH8.1
Assay category: BCell
Result: Positive
Host: M 56 years

Epitope: Epitope of mAb 10E8 on HIV-1 gp120
Chemical type: Peptide from protein
Sequence: NEQELLELDKWASLWNWFDITNWLWYIR
Position: 631-658
Source molecule (GenBank): ADZ13338.1
Assay category: BCell
Result: Positive
Host: M 56 years

Epitope: Epitope of mAb 10E8 on HIV-1 gp120
Chemical type: Peptide from protein
Sequence: NEQELLELDKWASLWNWFDITNWLWYIR
Position: 631-658
Source molecule (GenBank): ADZ13338.1
Assay category: BCell
Result: Positive