Reference: Mateusz Makuch; Josine van Beek; Carla A Wijbrandts; Marja Aalbers; Philippe Stas; Alexander B Meijer; Anja Ten Brinke; Theo Rispens; Paul Peter Tak; Gertjan Wolbink; Janine Schuurman; Paul W H I Parren; S Marieke van Ham. "The TNFα-binding domain of the therapeutic antibody adalimumab elicits CD4 T-cell responses in rheumatoid arthritis patients." Frontiers in immunology (2025).

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 363 365

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: H41-62 (Eluted Peptide 1)
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYAD
Position: 41-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 365

Epitope: Eluted Peptide 2
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDY
Position: 41-60
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: Eluted Peptide 2
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDY
Position: 41-60
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 363 365

Epitope: Eluted Peptide 2
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDY
Position: 41-60
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 2
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDY
Position: 41-60
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: Eluted Peptide 3
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHID
Position: 41-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: Eluted Peptide 3
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHID
Position: 41-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 363 365

Epitope: Eluted Peptide 3
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHID
Position: 41-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 3
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHID
Position: 41-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 365

Epitope: Eluted Peptide 3
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHID
Position: 41-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: Eluted Peptide 4
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHI
Position: 41-58
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 363 365

Epitope: Eluted Peptide 5
Chemical type: Peptide from protein
Sequence: GKGLEWVSAITWNSGHIDYAD
Position: 42-62
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 64 407 363 365

Epitope: Eluted Peptide 6
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGHIDYA
Position: 41-61
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 7
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSGH
Position: 41-57
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 8
Chemical type: Peptide from protein
Sequence: PGKGLEWVSAITWNSG
Position: 41-56
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 9
Chemical type: Peptide from protein
Sequence: GKGLEWVSAITWNSGHID
Position: 42-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 10
Chemical type: Peptide from protein
Sequence: KGLEWVSAITWNSGHID
Position: 43-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: Eluted Peptide 10
Chemical type: Peptide from protein
Sequence: KGLEWVSAITWNSGHID
Position: 43-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 10
Chemical type: Peptide from protein
Sequence: KGLEWVSAITWNSGHID
Position: 43-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: Eluted Peptide 11
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHID
Position: 44-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: Eluted Peptide 11
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHID
Position: 44-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 11
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHID
Position: 44-59
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: Eluted Peptide 12
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHI
Position: 44-58
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 52 430 360

Epitope: Eluted Peptide 12
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHI
Position: 44-58
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 12
Chemical type: Peptide from protein
Sequence: GLEWVSAITWNSGHI
Position: 44-58
Source molecule (GenBank): 6CR1_H
Assay category: MhcLigandElution
Result: Positive

Epitope: Eluted Peptide 13
Chemical type: Peptide from protein
Sequence: RASQGIRNYLAWYQQK
Position: 24-39
Source molecule (GenBank): 6CR1_L
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 14
Chemical type: Peptide from protein
Sequence: ASQGIRNYLAWYQQK
Position: 25-39
Source molecule (GenBank): 6CR1_L
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: Eluted Peptide 16
Chemical type: Peptide from protein
Sequence: SQGIRNYLAWYQQK
Position: 26-39
Source molecule (GenBank): 6CR1_L
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 426 358 360

Epitope: H47-68
Chemical type: Peptide from protein
Sequence: WVSAITWNSGHIDYADSVEGRF
Position: 47-68
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H47-68
Chemical type: Peptide from protein
Sequence: WVSAITWNSGHIDYADSVEGRF
Position: 47-68
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H88-109
Chemical type: Peptide from protein
Sequence: AEDTAVYYCAKVSYLSTASSLD
Position: 88-109
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: H88-109
Chemical type: Peptide from protein
Sequence: AEDTAVYYCAKVSYLSTASSLD
Position: 88-109
Source molecule (GenBank): 6CR1_H
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: L18-39
Chemical type: Peptide from protein
Sequence: RVTITCRASQGIRNYLAWYQQK
Position: 18-39
Source molecule (GenBank): 6CR1_L
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: L18-39
Chemical type: Peptide from protein
Sequence: RVTITCRASQGIRNYLAWYQQK
Position: 18-39
Source molecule (GenBank): 6CR1_L
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo