Reference: Raphaël Porret; Fanny Lebreton; Eleonora Pace; Evangelos Stefanidis; Aikaterini Semilietof; Philippe Guillaume; Spiros Georgakis; Oscar Alfageme-Abello; Ana Alcaraz-Serna; Laura Ermellino; Rebecca Cecchin; Erica Lana; Morteza Hafezi; Francesco Procopio; Kevin Bellofatto; Greta Maria Paola Giordano Attianese; Vincent Zoete; Matthieu Perreau; Constantinos Petrovas; Melita Irving; Ekaterine Berishvili; Qizhi Tang; Yannick D Muller. "Dual CD8 and TCR editing in regulatory T cells mediates HLA-A2-restricted tissue-specific homing." Molecular therapy : the journal of the American Society of Gene Therapy (2026).

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: ZnT8 186-194
Chemical type: Peptide from protein
Sequence: VAANIVLTV
Position: 186-194
Source molecule (GenBank): Q8IWU4.2
Assay category: MhcBinding
Result: Positive

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: IGRP 265-273
Chemical type: Peptide from protein
Sequence: VLFGLGFAI
Position: 265-273
Source molecule (GenBank): Q9NQR9.1
Assay category: MhcBinding
Result: Positive

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLTV
Chemical type: Peptide, no natural source
Sequence: VLANIVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLAEIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAEIVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLAKIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAKIVLTV
Assay category: MhcBinding
Result: Positive

Epitope: VLARIVLTV
Chemical type: Peptide, no natural source
Sequence: VLARIVLTV
Assay category: MhcBinding
Result: Positive

Epitope: VLAHIVLTV
Chemical type: Peptide, no natural source
Sequence: VLAHIVLTV
Assay category: MhcBinding
Result: Positive

Epitope: VLANEVLTV
Chemical type: Peptide, no natural source
Sequence: VLANEVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANKVLTV
Chemical type: Peptide, no natural source
Sequence: VLANKVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANRVLTV
Chemical type: Peptide, no natural source
Sequence: VLANRVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANHVLTV
Chemical type: Peptide, no natural source
Sequence: VLANHVLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIELTV
Chemical type: Peptide, no natural source
Sequence: VLANIELTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIKLTV
Chemical type: Peptide, no natural source
Sequence: VLANIKLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIHLTV
Chemical type: Peptide, no natural source
Sequence: VLANIHLTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIRLTV
Chemical type: Peptide, no natural source
Sequence: VLANIRLTV
Assay category: MhcBinding
Result: Positive

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVETV
Chemical type: Peptide, no natural source
Sequence: VLANIVETV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIVKTV
Chemical type: Peptide, no natural source
Sequence: VLANIVKTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIVRTV
Chemical type: Peptide, no natural source
Sequence: VLANIVRTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIVHTV
Chemical type: Peptide, no natural source
Sequence: VLANIVHTV
Assay category: MhcBinding
Result: Positive-Low

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLEV
Chemical type: Peptide, no natural source
Sequence: VLANIVLEV
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: VLANIVLKV
Chemical type: Peptide, no natural source
Sequence: VLANIVLKV
Assay category: MhcBinding
Result: Positive

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLRV
Chemical type: Peptide, no natural source
Sequence: VLANIVLRV
Assay category: MhcBinding
Result: Positive

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: VLANIVLHV
Chemical type: Peptide, no natural source
Sequence: VLANIVLHV
Assay category: MhcBinding
Result: Positive