Reference: Jun Kuai; Lidia Mosyak; Jon Brooks; Michael Cain; Gregory J Carven; Shinji Ogawa; Tetsuya Ishino; May Tam; Edward R Lavallie; Zhiyong Yang; Dirk Ponsel; Robert Rauchenberger; Robert Arch; Nick Pullen. "Characterization of binding mode of action of a blocking anti-platelet-derived growth factor (PDGF)-B monoclonal antibody, MOR8457, reveals conformational flexibility and avidity needed for PDGF-BB to bind PDGF receptor-β." Biochemistry (2015).

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 17700000

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000447

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 6500000.0

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00045

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 12700000

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000362

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.01

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 29500000

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000293

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.025

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.069

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of MOR8457 on PDGF-BB homodimer
Chemical type: Region on multi-chain protein
Discontinuous residues: C: L119, V120, W121, Q152, R154, I156, I158, R160, K161, K162, P163, I164, F165, K166, K167; D: N135, R137
Source molecule (GenBank): NP_002599.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.028