Reference: Yan G Ni; Stefania Di Marco; Jon H Condra; Laurence B Peterson; Weirong Wang; Fubao Wang; Shilpa Pandit; Holly A Hammond; Ray Rosa; Richard T Cummings; Dana D Wood; Xiaomei Liu; Matthew J Bottomley; Xun Shen; Rose M Cubbon; Sheng-ping Wang; Douglas G Johns; Cinzia Volpari; Lora Hamuro; Jayne Chin; Lingyi Huang; Jing Zhang Zhao; Salvatore Vitelli; Peter Haytko; Douglas Wisniewski; Lyndon J Mitnaul; Carl P Sparrow; Brian Hubbard; Andrea Carfí; Ayesha Sitlani. "A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo." Journal of lipid research (2011).

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 72100.0

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000316

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 672000.0

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000215

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 3.89

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 113000.0

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000434

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 3.2

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 4.4

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.7

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive

Epitope: Epitope of 1D05 Fab on PCSK9
Chemical type: Discontinuous protein residues
Discontinuous residues: P155, D192, R194, E197, A220, S221, R237, D238, A239, I369, S372, D374, C375, S376, T377, C378, F379, V380, S381, Q382
Source molecule (GenBank): Q8NBP7.3
Assay category: BCell
Result: Positive