Reference: Yoshihiro Watanabe; Natsuko Hosokawa; Misaki Yoshida; Tomoyuki Miura; Mitsuhiro Kawano. "Identification of Closed Linear Epitopes in S1-RBD and S2-HR1/2 of SARS-CoV-2 Spike Protein Able to Induce Neutralizing Abs." Vaccines (2023).

Epitope: RBD 1
Chemical type: Peptide from protein
Sequence: SNFRVQPTESIVRFPNITNLC
Position: 316-336
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 1
Chemical type: Peptide from protein
Sequence: SNFRVQPTESIVRFPNITNLC
Position: 316-336
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 1
Chemical type: Peptide from protein
Sequence: SNFRVQPTESIVRFPNITNLC
Position: 316-336
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 1
Chemical type: Peptide from protein
Sequence: SNFRVQPTESIVRFPNITNLC
Position: 316-336
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 2
Chemical type: Peptide from protein
Sequence: CPFGEVFNATRFASVYAWNR
Position: 336-355
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 2
Chemical type: Peptide from protein
Sequence: CPFGEVFNATRFASVYAWNR
Position: 336-355
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 3
Chemical type: Peptide from protein
Sequence: NATRFASVYAWNRKRISNC
Position: 343-361
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 3
Chemical type: Peptide from protein
Sequence: NATRFASVYAWNRKRISNC
Position: 343-361
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 3
Chemical type: Peptide from protein
Sequence: NATRFASVYAWNRKRISNC
Position: 343-361
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 3
Chemical type: Peptide from protein
Sequence: NATRFASVYAWNRKRISNC
Position: 343-361
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 4
Chemical type: Peptide from protein
Sequence: CVADYSVLYNSASFSTFKC
Position: 361-379
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 4
Chemical type: Peptide from protein
Sequence: CVADYSVLYNSASFSTFKC
Position: 361-379
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 5
Chemical type: Peptide from protein
Sequence: YGVSPTKLNDLCF
Position: 380-392
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 5
Chemical type: Peptide from protein
Sequence: YGVSPTKLNDLCF
Position: 380-392
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 5
Chemical type: Peptide from protein
Sequence: YGVSPTKLNDLCF
Position: 380-392
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 5
Chemical type: Peptide from protein
Sequence: YGVSPTKLNDLCF
Position: 380-392
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 6
Chemical type: Peptide from protein
Sequence: CFTNVYADSFVIRGDEVRQIAPGQ
Position: 391-414
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 6
Chemical type: Peptide from protein
Sequence: CFTNVYADSFVIRGDEVRQIAPGQ
Position: 391-414
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 6
Chemical type: Peptide from protein
Sequence: CFTNVYADSFVIRGDEVRQIAPGQ
Position: 391-414
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 8
Chemical type: Peptide from protein
Sequence: EVRQIAPGQTGKIADYNYKLPD
Position: 406-427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 8
Chemical type: Peptide from protein
Sequence: EVRQIAPGQTGKIADYNYKLPD
Position: 406-427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 8
Chemical type: Peptide from protein
Sequence: EVRQIAPGQTGKIADYNYKLPD
Position: 406-427
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 9
Chemical type: Peptide from protein
Sequence: GCVIAWNSNNLDSKVGGN
Position: 431-448
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 9
Chemical type: Peptide from protein
Sequence: GCVIAWNSNNLDSKVGGN
Position: 431-448
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 11
Chemical type: Peptide from protein
Sequence: SNLKPFERDISTEIYQAGSTPC
Position: 459-480
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 11
Chemical type: Peptide from protein
Sequence: SNLKPFERDISTEIYQAGSTPC
Position: 459-480
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 11
Chemical type: Peptide from protein
Sequence: SNLKPFERDISTEIYQAGSTPC
Position: 459-480
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 11
Chemical type: Peptide from protein
Sequence: SNLKPFERDISTEIYQAGSTPC
Position: 459-480
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 11
Chemical type: Peptide from protein
Sequence: SNLKPFERDISTEIYQAGSTPC
Position: 459-480
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 12
Chemical type: Peptide from protein
Sequence: PCNGVEGFNCYFPLQSYGFQP
Position: 479-499
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 12
Chemical type: Peptide from protein
Sequence: PCNGVEGFNCYFPLQSYGFQP
Position: 479-499
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 12
Chemical type: Peptide from protein
Sequence: PCNGVEGFNCYFPLQSYGFQP
Position: 479-499
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: RBD 13
Chemical type: Peptide from protein
Sequence: TNGVGYQPYRVVVLSF
Position: 500-515
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 13
Chemical type: Peptide from protein
Sequence: TNGVGYQPYRVVVLSF
Position: 500-515
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 14
Chemical type: Peptide from protein
Sequence: GYQPYRVVVLSFELLHAPATVC
Position: 504-525
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: RBD 14
Chemical type: Peptide from protein
Sequence: GYQPYRVVVLSFELLHAPATVC
Position: 504-525
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 101
Chemical type: Peptide from protein
Sequence: QMAYRFNGIGVTQNVLYENQ
Position: 901-920
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 101
Chemical type: Peptide from protein
Sequence: QMAYRFNGIGVTQNVLYENQ
Position: 901-920
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 101
Chemical type: Peptide from protein
Sequence: QMAYRFNGIGVTQNVLYENQ
Position: 901-920
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 101
Chemical type: Peptide from protein
Sequence: QMAYRFNGIGVTQNVLYENQ
Position: 901-920
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 102
Chemical type: Peptide from protein
Sequence: VTQNVLYENQKLIANQFNS
Position: 911-929
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 102
Chemical type: Peptide from protein
Sequence: VTQNVLYENQKLIANQFNS
Position: 911-929
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 102
Chemical type: Peptide from protein
Sequence: VTQNVLYENQKLIANQFNS
Position: 911-929
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 102
Chemical type: Peptide from protein
Sequence: VTQNVLYENQKLIANQFNS
Position: 911-929
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 103
Chemical type: Peptide from protein
Sequence: QKLIANQFNSAIGKIQDSLSS
Position: 920-940
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 103
Chemical type: Peptide from protein
Sequence: QKLIANQFNSAIGKIQDSLSS
Position: 920-940
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 103
Chemical type: Peptide from protein
Sequence: QKLIANQFNSAIGKIQDSLSS
Position: 920-940
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 103
Chemical type: Peptide from protein
Sequence: QKLIANQFNSAIGKIQDSLSS
Position: 920-940
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 104
Chemical type: Peptide from protein
Sequence: SAIGKIQDSLSSTASALGKLQD
Position: 929-950
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 104
Chemical type: Peptide from protein
Sequence: SAIGKIQDSLSSTASALGKLQD
Position: 929-950
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: S2-HR1 104
Chemical type: Peptide from protein
Sequence: SAIGKIQDSLSSTASALGKLQD
Position: 929-950
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: S2-HR1 104
Chemical type: Peptide from protein
Sequence: SAIGKIQDSLSSTASALGKLQD
Position: 929-950
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 105
Chemical type: Peptide from protein
Sequence: SALGKLQDVVNQNAQALNTLVK
Position: 943-964
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 105
Chemical type: Peptide from protein
Sequence: SALGKLQDVVNQNAQALNTLVK
Position: 943-964
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 105
Chemical type: Peptide from protein
Sequence: SALGKLQDVVNQNAQALNTLVK
Position: 943-964
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low

Epitope: S2-HR1 105
Chemical type: Peptide from protein
Sequence: SALGKLQDVVNQNAQALNTLVK
Position: 943-964
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 106
Chemical type: Peptide from protein
Sequence: DVVNQNAQALNTLVKQLSSNFG
Position: 950-971
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 106
Chemical type: Peptide from protein
Sequence: DVVNQNAQALNTLVKQLSSNFG
Position: 950-971
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 106
Chemical type: Peptide from protein
Sequence: DVVNQNAQALNTLVKQLSSNFG
Position: 950-971
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 106
Chemical type: Peptide from protein
Sequence: DVVNQNAQALNTLVKQLSSNFG
Position: 950-971
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 107
Chemical type: Peptide from protein
Sequence: VKQLSSNFGAISSVLNDILSRLD
Position: 963-985
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 107
Chemical type: Peptide from protein
Sequence: VKQLSSNFGAISSVLNDILSRLD
Position: 963-985
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 107
Chemical type: Peptide from protein
Sequence: VKQLSSNFGAISSVLNDILSRLD
Position: 963-985
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 107
Chemical type: Peptide from protein
Sequence: VKQLSSNFGAISSVLNDILSRLD
Position: 963-985
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 108
Chemical type: Peptide from protein
Sequence: VLNDILSRLDKVEAEVQIDR
Position: 976-995
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 108
Chemical type: Peptide from protein
Sequence: VLNDILSRLDKVEAEVQIDR
Position: 976-995
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 108
Chemical type: Peptide from protein
Sequence: VLNDILSRLDKVEAEVQIDR
Position: 976-995
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 108
Chemical type: Peptide from protein
Sequence: VLNDILSRLDKVEAEVQIDR
Position: 976-995
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 109
Chemical type: Peptide from protein
Sequence: EAEVQIDRLITGRLQSLQT
Position: 988-1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 109
Chemical type: Peptide from protein
Sequence: EAEVQIDRLITGRLQSLQT
Position: 988-1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 109
Chemical type: Peptide from protein
Sequence: EAEVQIDRLITGRLQSLQT
Position: 988-1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 109
Chemical type: Peptide from protein
Sequence: EAEVQIDRLITGRLQSLQT
Position: 988-1006
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR1 110
Chemical type: Peptide from protein
Sequence: GRLQSLQTYVTQQLIRAAEIR
Position: 999-1019
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 110
Chemical type: Peptide from protein
Sequence: GRLQSLQTYVTQQLIRAAEIR
Position: 999-1019
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 110
Chemical type: Peptide from protein
Sequence: GRLQSLQTYVTQQLIRAAEIR
Position: 999-1019
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR1 110
Chemical type: Peptide from protein
Sequence: GRLQSLQTYVTQQLIRAAEIR
Position: 999-1019
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 112
Chemical type: Peptide from protein
Sequence: KYFKNHTSPDVDLGD
Position: 1154-1168
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 112
Chemical type: Peptide from protein
Sequence: KYFKNHTSPDVDLGD
Position: 1154-1168
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 112
Chemical type: Peptide from protein
Sequence: KYFKNHTSPDVDLGD
Position: 1154-1168
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 112
Chemical type: Peptide from protein
Sequence: KYFKNHTSPDVDLGD
Position: 1154-1168
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 113
Chemical type: Peptide from protein
Sequence: DVDLGDISGINASVVNIQK
Position: 1163-1181
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 113
Chemical type: Peptide from protein
Sequence: DVDLGDISGINASVVNIQK
Position: 1163-1181
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 113
Chemical type: Peptide from protein
Sequence: DVDLGDISGINASVVNIQK
Position: 1163-1181
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 113
Chemical type: Peptide from protein
Sequence: DVDLGDISGINASVVNIQK
Position: 1163-1181
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 114
Chemical type: Peptide from protein
Sequence: ASVVNIQKEIDRLNEVAKNL
Position: 1174-1193
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 114
Chemical type: Peptide from protein
Sequence: ASVVNIQKEIDRLNEVAKNL
Position: 1174-1193
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 114
Chemical type: Peptide from protein
Sequence: ASVVNIQKEIDRLNEVAKNL
Position: 1174-1193
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 114
Chemical type: Peptide from protein
Sequence: ASVVNIQKEIDRLNEVAKNL
Position: 1174-1193
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 114
Chemical type: Peptide from protein
Sequence: ASVVNIQKEIDRLNEVAKNL
Position: 1174-1193
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 115
Chemical type: Peptide from protein
Sequence: DRLNEVAKNLNESLIDLQE
Position: 1184-1202
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 115
Chemical type: Peptide from protein
Sequence: DRLNEVAKNLNESLIDLQE
Position: 1184-1202
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 115
Chemical type: Peptide from protein
Sequence: DRLNEVAKNLNESLIDLQE
Position: 1184-1202
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 115
Chemical type: Peptide from protein
Sequence: DRLNEVAKNLNESLIDLQE
Position: 1184-1202
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 115
Chemical type: Peptide from protein
Sequence: DRLNEVAKNLNESLIDLQE
Position: 1184-1202
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 116
Chemical type: Peptide from protein
Sequence: LIDLQELGKYEQYIKWP
Position: 1197-1213
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 116
Chemical type: Peptide from protein
Sequence: LIDLQELGKYEQYIKWP
Position: 1197-1213
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 116
Chemical type: Peptide from protein
Sequence: LIDLQELGKYEQYIKWP
Position: 1197-1213
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: S2-HR2 116
Chemical type: Peptide from protein
Sequence: LIDLQELGKYEQYIKWP
Position: 1197-1213
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 117
Chemical type: Peptide from protein
Sequence: KYEQYIKWPWYIWLGFIAG
Position: 1205-1223
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 117
Chemical type: Peptide from protein
Sequence: KYEQYIKWPWYIWLGFIAG
Position: 1205-1223
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 117
Chemical type: Peptide from protein
Sequence: KYEQYIKWPWYIWLGFIAG
Position: 1205-1223
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative

Epitope: S2-HR2 117
Chemical type: Peptide from protein
Sequence: KYEQYIKWPWYIWLGFIAG
Position: 1205-1223
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Negative