Reference: Gavuthami Murugesan; Rachel L Paterson; Rakesh Kulkarni; Veronica Ilkow; Richard J Suckling; Mary M Connolly; Vijaykumar Karuppiah; Robert Pengelly; Archana Jadhav; Jose Donoso; Tiaan Heunis; Wilawan Bunjobpol; Gwilym Philips; Kafayat Ololade; Daniel Kay; Anshuk Sarkar; Claire Barber; Ritu Raj; Carole Perot; Tressan Grant; Agatha Treveil; Andrew Walker; Marcin Dembek; Dawn Gibbs-Howe; Miriam Hock; Ricardo J Carreira; Kate E Atkin; Lucy Dorrell; Andrew Knox; Sarah Leonard; Mariolina Salio; Luis F Godinho. "Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen." Nature communications (2024).

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: TCell
Result: Positive
Quantitative measurement: 2.25

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: TCell
Result: Positive
Quantitative measurement: 0.00819

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: TCell
Result: Positive
Quantitative measurement: 0.00544

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.25

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 43.6

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 6.7

Epitope: HBV ENV 371-379
Chemical type: Peptide from protein
Sequence: ILSPFLPLL
Position: 371-379
Source molecule (GenBank): Q67879
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.35

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: TCell
Result: Positive
Quantitative measurement: 0.0112

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: TCell
Result: Positive
Quantitative measurement: 0.00981

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.35

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 46.9

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 39.5

Epitope: HBV ENV 371-379 (S3N)
Chemical type: Peptide from protein
Sequence: ILNPFLPLL
Position: 382-390
Source molecule (GenBank): AAZ05273.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Quantitative measurement: 0.00498

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Quantitative measurement: 0.00448

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Host:  36-60 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: TCell
Result: Positive
Quantitative measurement: 2.61

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.61

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 48.6

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 120.0

Epitope: HBV ENV 371-379 (L6I)
Chemical type: Peptide from protein
Sequence: ILSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97192.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader Cw3
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): A0A0G2JIF0.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 48.8

Epitope: Leader Cw3
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): A0A0G2JIF0.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 114.0

Epitope: Leader Cw3
Chemical type: Peptide from protein
Sequence: VMAPRTLIL
Position: 3-11
Source molecule (GenBank): A0A0G2JIF0.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader A1
Chemical type: Peptide from protein
Sequence: VMAPRTLL
Position: 3-10
Source molecule (GenBank): NP_002107.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 48.8

Epitope: Leader A1
Chemical type: Peptide from protein
Sequence: VMAPRTLL
Position: 3-10
Source molecule (GenBank): NP_002107.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 119.0

Epitope: Leader A1
Chemical type: Peptide from protein
Sequence: VMAPRTLL
Position: 3-10
Source molecule (GenBank): NP_002107.3
Assay category: MhcBinding
Result: Positive

Epitope: Leader B7
Chemical type: Peptide from protein
Sequence: VMAPRTVLL
Position: 3-11
Source molecule (GenBank): AAA59622.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader B7
Chemical type: Peptide from protein
Sequence: VMAPRTVLL
Position: 3-11
Source molecule (GenBank): AAA59622.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader A80
Chemical type: Peptide from protein
Sequence: VMPPRTLLL
Position: 3-11
Source molecule (GenBank): Q09160.1
Assay category: MhcBinding
Result: Positive

Epitope: Leader A80
Chemical type: Peptide from protein
Sequence: VMPPRTLLL
Position: 3-11
Source molecule (GenBank): Q09160.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (L2V-S3R-L6I)
Chemical type: Peptide from protein
Sequence: IVRPFIPLL
Position: 382-390
Source molecule (GenBank): CAC87026.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV ENV 371-379 (L2V-S3R-L6I)
Chemical type: Peptide from protein
Sequence: IVRPFIPLL
Position: 382-390
Source molecule (GenBank): CAC87026.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV ENV 371-379 (L2V-L6I)
Chemical type: Peptide from protein
Sequence: IVSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97183.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (L2V-L6I)
Chemical type: Peptide from protein
Sequence: IVSPFIPLL
Position: 371-379
Source molecule (GenBank): AAK97183.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (L6M)
Chemical type: Peptide from protein
Sequence: ILSPFMPLL
Position: 371-379
Source molecule (GenBank): AAL66328.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (L6M)
Chemical type: Peptide from protein
Sequence: ILSPFMPLL
Position: 371-379
Source molecule (GenBank): AAL66328.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (I1T)
Chemical type: Peptide from protein
Sequence: TLSPFLPLL
Position: 208-216
Source molecule (GenBank): ABE01571.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV ENV 371-379 (I1T)
Chemical type: Peptide from protein
Sequence: TLSPFLPLL
Position: 208-216
Source molecule (GenBank): ABE01571.1
Assay category: MhcBinding
Result: Positive

Epitope: HBV Env 253-261
Chemical type: Peptide from protein
Sequence: CLIFLLVLL
Position: 253-261
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 170-178
Chemical type: Peptide from protein
Sequence: GFLGPLLVL
Position: 170-178
Source molecule (GenBank): Q8QSF2.2
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 243-251
Chemical type: Peptide from protein
Sequence: FIIFLFILL
Position: 243-251
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 39.3

Epitope: HBV Env 196-204
Chemical type: Peptide from protein
Sequence: DSWWTSLNF
Position: 196-204
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 244-252
Chemical type: Peptide from protein
Sequence: IIFLFILLL
Position: 244-252
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 250-258
Chemical type: Peptide from protein
Sequence: LLLCLIFLL
Position: 250-258
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 169-177
Chemical type: Peptide from protein
Sequence: TSGFLGPLL
Position: 168-176
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 265-273
Chemical type: Peptide from protein
Sequence: GMLPVCPLL
Position: 265-273
Source molecule (GenBank): Q8QSF2.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 45.3

Epitope: HBV Env 177-185
Chemical type: Peptide from protein
Sequence: VLQAGFFLL
Position: 177-185
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 312-321
Chemical type: Peptide from protein
Sequence: CIPIPSSWAF
Position: 312-321
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 42.1

Epitope: HBV Env 317-325
Chemical type: Peptide from protein
Sequence: SSWAFARFL
Position: 328-336
Source molecule (GenBank): Q2EID8.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 40.7

Epitope: HBV Env 176-185
Chemical type: Peptide from protein
Sequence: LVLQAGFFLL
Position: 176-185
Source molecule (GenBank): V5JZH5.1
Assay category: MhcBinding
Result: Negative

Epitope: HBV Env 330-339
Chemical type: Peptide from protein
Sequence: SVRFSWLSLL
Position: 330-339
Source molecule (GenBank): Q8QSF2.2
Assay category: MhcBinding
Result: Negative