Reference: Dan Lu; Yuan Chen; Min Jiang; Jie Wang; Yiting Li; Keke Ma; Wenqiao Sun; Xing Zheng; Jianxun Qi; Wenjing Jin; Yu Chen; Yan Chai; Catherine W H Zhang; Hao Liang; Shuguang Tan; George F Gao. "KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors." Nature communications (2023).

Epitope: KRAS-G12wt-9 peptide
Chemical type: Peptide from protein
Sequence: VVGAGGVGK
Position: 8-16
Source molecule (GenBank): G3V4K2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.2

Epitope: KRAS-G12wt-9 peptide
Chemical type: Peptide from protein
Sequence: VVGAGGVGK
Position: 8-16
Source molecule (GenBank): G3V4K2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 52.18

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 42500.0
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 14000.0
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 28000.0
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 131000.0
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-Low
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive-Low
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Host:  8-12 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 3.34
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: TCell
Result: Positive
Quantitative measurement: 3.3
Host:  8-12 weeks

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.34

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.3

Epitope: KRAS-G12V-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 58.52

Epitope: KRAS-G12C-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 42500.0
Host:  8-12 weeks

Epitope: KRAS-G12C-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: TCell
Result: Positive-Low
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12C-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: TCell
Result: Positive-Low
Host:  8-12 weeks
Cell type: HEK293 cell (epithelial cell)
Tissue: kidney
Culture conditions: Engineered

Epitope: KRAS-G12C-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: TCell
Result: Positive-Low
Quantitative measurement: 131000.0
Host:  8-12 weeks

Epitope: KRAS-G12C-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGACGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 48.54

Epitope: KRAS-G12D-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGADGVGK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 55.55

Epitope: KRAS-G12A-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAAGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12S-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGASGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12R-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGARGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G13D-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAGDVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12-V1A-9 peptide
Chemical type: Peptide, no natural source
Sequence: AVGAVGVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12-G6A-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVAVGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12-V7A-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGAGK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12-G8A-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVAK
Assay category: MhcBinding
Result: Positive

Epitope: KRAS-G12-K9A-9 peptide
Chemical type: Peptide, no natural source
Sequence: VVGAVGVGA
Assay category: MhcBinding
Result: Negative