Reference: Mario Mietzsch; Jane Hsi; Austin R Nelson; Neeta Khandekar; Ann-Maree Huang; Nicholas Jc Smith; Jon Zachary; Lindsay Potts; Michelle A Farrar; Paul Chipman; Mohammad Ghanem; Ian E Alexander; Grant J Logan; Juha T Huiskonen; Robert McKenna. "Structural characterization of antibody-responses following Zolgensma treatment for AAV capsid engineering to expand patient cohorts." Nature communications (2025).

Epitope: Epitope of Fab1-1 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: Q579, T582, A587, Q588, Q590, Q592, T593, W595, Q597, N598; C: S454, V580, T582, Q588, Q590, A591, Q592, T593, G594, W595, V596, Q597, N598
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-1 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: Q579, T582, A587, Q588, Q590, Q592, T593, W595, Q597, N598; C: S454, V580, T582, Q588, Q590, A591, Q592, T593, G594, W595, V596, Q597, N598
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: S261, N262, S263, T264, S265, G266, G267, S268, S269, N270, D384, S386, Q387, W503, P504; B: Q588
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: S261, N262, S263, T264, S265, G266, G267, S268, S269, N270, D384, S386, Q387, W503, P504; B: Q588
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q458, Q459, T460; C: T491, V493, T494, Q495, S526, H527, D532, R533, F534, F535, K545, D554, D556, V558, I560, N562, Y706, K707, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q458, Q459, T460; C: T491, V493, T494, Q495, S526, H527, D532, R533, F534, F535, K545, D554, D556, V558, I560, N562, Y706, K707, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-4 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q458, Q459, T460; C: T491, T492, V493, Q495, H527, G530, D532, R533, K545, D554, A555, D556, K557, M559, I560, N562, E564, N704, Y706, K707, E712, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-4 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q458, Q459, T460; C: T491, T492, V493, Q495, H527, G530, D532, R533, K545, D554, A555, D556, K557, M559, I560, N562, E564, N704, Y706, K707, E712, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A656, D657, P658, P659, T660, S669; B: N254, I260, S261, T264, Y274, V325, D327, N329, G330, K332, G547, G549, R550, D551, N552, V553, N668, S669, F670, T672
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: A656, D657, P658, P659, T660, S669; B: N254, I260, S261, T264, Y274, V325, D327, N329, G330, K332, G547, G549, R550, D551, N552, V553, N668, S669, F670, T672
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: Q456, Q458, Q459; C: T491, T492, V493, T494, Q495, D532, R533, K545, D554, D556, N704, Y705, Y706, K707, S708, N709, R725
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab1-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: Q456, Q458, Q459; C: T491, T492, V493, T494, Q495, D532, R533, K545, D554, D556, N704, Y705, Y706, K707, S708, N709, R725
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-1 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, V493, T494, S526, H527, E529, G530, D532, R533, F534, F535, S540, A555, D556, I560, T561, N562, E564, I699, N704, Y706, R725; D: Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-1 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, V493, T494, S526, H527, E529, G530, D532, R533, F534, F535, S540, A555, D556, I560, T561, N562, E564, I699, N704, Y706, R725; D: Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, V493, Q495, S526, H527, E529, G530, D532, R533, F534, F535, D556, I560, T561, N562, K567, Y705, K707, S708, N709; D: N270, D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, V493, Q495, S526, H527, E529, G530, D532, R533, F534, F535, D556, I560, T561, N562, K567, Y705, K707, S708, N709; D: N270, D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, T460, K462; C: T491, T492, Q495, S526, H527, G530, D532, R533, F534, F535, D554, A555, D556, I560, T561, N562, E564, E565, Y613, Y706, N709, R725, P726, G728
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, T460, K462; C: T491, T492, Q495, S526, H527, G530, D532, R533, F534, F535, D554, A555, D556, I560, T561, N562, E564, E565, Y613, Y706, N709, R725, P726, G728
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-4 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q459, T460; C: T491, T492, V493, T494, G530, E531, D532, R533, F534, M559, I560, T561, N562, Y701, N704, Y706, R725, P726, I727, G728, Y731
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-4 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q459, T460; C: T491, T492, V493, T494, G530, E531, D532, R533, F534, M559, I560, T561, N562, Y701, N704, Y706, R725, P726, I727, G728, Y731
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-5 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q459, T460; C: T491, T492, V493, T494, D532, R533, K545, D554, A555, D556, K557, V558, M559, I560, Y706, K707, P724, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-5 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N452, Q456, N457, Q459, T460; C: T491, T492, V493, T494, D532, R533, K545, D554, A555, D556, K557, V558, M559, I560, Y706, K707, P724, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: T460; C: T491, V493, S526, H527, G530, D532, R533, F534, F535, S540, D554, D556, I560, T561, N562, E564, N704, Y706, N709, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: T460; C: T491, V493, S526, H527, G530, D532, R533, F534, F535, S540, D554, D556, I560, T561, N562, E564, N704, Y706, N709, R725, P726
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G330, K332, I334, D551, N552, T717, E718; E: N254, L256, K258, T264, E324, V325, T326, D327, A656, N668, S669, F670, I671, T672
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab2-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G330, K332, I334, D551, N552, T717, E718; E: N254, L256, K258, T264, E324, V325, T326, D327, A656, N668, S669, F670, I671, T672
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, T494, S526, H527, G530, D532, R533, F534, F535, D556, I560, T561, N562, E564, N704, Y706, K707, R725, P726; D: Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-2 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, T494, S526, H527, G530, D532, R533, F534, F535, D556, I560, T561, N562, E564, N704, Y706, K707, R725, P726; D: Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q458, Q459; C: T491, T492, V493, T494, Q495, N498, G530, E531, D532, R533, K545, D554, D556, N562, N704, Y705, Y706, S708, P724
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-3 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q458, Q459; C: T491, T492, V493, T494, Q495, N498, G530, E531, D532, R533, K545, D554, D556, N562, N704, Y705, Y706, S708, P724
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-5 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q458, Q459; C: T491, T492, V493, T494, Q495, S526, H527, D532, R533, F534, F535, D554, A555, I560, T561, N562, N704, Y706, R725, P726, I727, G728, Y731
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-5 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: B: N457, Q458, Q459; C: T491, T492, V493, T494, Q495, S526, H527, D532, R533, F534, F535, D554, A555, I560, T561, N562, N704, Y706, R725, P726, I727, G728, Y731
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T492, V493, T494, S526, H527, G530, E531, D532, R533, F534, F535, I560, T561, N562, E564, E565, N704, Y706, K707, S708, N709; D: N270, D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-6 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T492, V493, T494, S526, H527, G530, E531, D532, R533, F534, F535, I560, T561, N562, E564, E565, N704, Y706, K707, S708, N709; D: N270, D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, V493, Q495, S526, G530, D532, R533, F534, F535, D554, D556, K557, M559, I560, T561, N562, E564, Y701, T702, S703, N704, K707, S708, N709, R725, P726, I727, G728, Y731; D: D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: Epitope of Fab3-7 on AAV9 capsid
Chemical type: Region on multi-chain protein
Discontinuous residues: C: T491, T492, V493, Q495, S526, G530, D532, R533, F534, F535, D554, D556, K557, M559, I560, T561, N562, E564, Y701, T702, S703, N704, K707, S708, N709, R725, P726, I727, G728, Y731; D: D384, G385, Q387
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: hAEV6 epitope residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T491, D556, N562, T582, Q588, Y706
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive
Host:  <1 year

Epitope: hAEV6 epitope residues
Chemical type: Discontinuous protein residues
Discontinuous residues: T491, D556, N562, T582, Q588, Y706
Source molecule (GenBank): Q6JC40
Assay category: BCell
Result: Positive