Reference: Zoltan Antal; Jason C Baker; Carla Smith; Irene Jarchum; Jeffrey Babad; Gayatri Mukherjee; Yang Yang; John Sidney; Alessandro Sette; Pere Santamaria; Teresa P DiLorenzo. "Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes." Journal of immunology (Baltimore, Md. : 1950) (2012).

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 21-24 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 21-24 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 15-17 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 428.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 209.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 49752.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 67.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1081.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 4547.0

Epitope: IGRP (272-280)
Chemical type: Peptide from protein
Sequence: AINSEMFLR
Position: 272-280
Source molecule (GenBank): NP_067306.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 109.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 21-24 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 21-24 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 15-17 weeks
Cell type: T cell CD8+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 13432.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3327.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 605.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 23280.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 13026.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 25455.0

Epitope: Ins1 C21-30
Chemical type: Peptide from protein
Sequence: TLALEVARQK
Position: 77-86
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 15-17 weeks
Cell type: T cell
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 21-24 weeks
Cell type: T cell
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 43592.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 42979.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 10808.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 9145.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 12966.0

Epitope: Ins1 C22-31
Chemical type: Peptide from protein
Sequence: LALEVARQKR
Position: 78-87
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 12582.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive
Host: F 15-17 weeks
Cell type: T cell
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 4.4

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 16115.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 35.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 10987.0

Epitope: Ins1 C15-24
Chemical type: Peptide from protein
Sequence: SPGDLQTLAL
Position: 71-80
Source molecule (GenBank): NP_032412.3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 37072.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 20873.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 39403.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 48509.0

Epitope: hIns C23–32
Chemical type: Peptide from protein
Sequence: PLALEGSLQ
Position: 67-75
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 41456.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 34461.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 17521.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 38387.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3271.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 515.0

Epitope: hIns C24–33
Chemical type: Peptide from protein
Sequence: LALEGSLQKR
Position: 68-77
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 66.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 462.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 6066.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 15456.0

Epitope: hIns C15–26
Chemical type: Peptide from protein
Sequence: GPGAGSLQPLAL
Position: 71-82
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0