Reference: Janine Kemming; Swantje Gundlach; Marcus Panning; Daniela Huzly; Jiabin Huang; Marc Lütgehetmann; Sven Pischke; Julian Schulze Zur Wiesch; Florian Emmerich; Sian Llewellyn-Lacey; David A Price; Yakup Tanriver; Klaus Warnatz; Tobias Boettler; Robert Thimme; Maike Hofmann; Nicole Fischer; Christoph Neumann-Haefelin. "Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infection." Journal of hepatology (2022).

Epitope: ORF2_389
Chemical type: Peptide from protein
Sequence: SSAGGQLFY
Position: 257-265
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_389
Chemical type: Peptide from protein
Sequence: SSAGGQLFY
Position: 257-265
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_389
Chemical type: Peptide from protein
Sequence: SSAGGQLFY
Position: 257-265
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_389
Chemical type: Peptide from protein
Sequence: SSAGGQLFY
Position: 257-265
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_369
Chemical type: Peptide from protein
Sequence: LTAVITAAY
Position: 369-377
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_176
Chemical type: Peptide from protein
Sequence: ATEASNYAQY
Position: 44-53
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_176
Chemical type: Peptide from protein
Sequence: ATEASNYAQY
Position: 44-53
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_176
Chemical type: Peptide from protein
Sequence: ATEASNYAQY
Position: 44-53
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_514
Chemical type: Peptide from protein
Sequence: HLDVSGTY
Position: 514-521
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_47
Chemical type: Peptide from protein
Sequence: DSQPFALPY
Position: 59-67
Source molecule (GenBank): Q9IVZ8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_298
Chemical type: Peptide from protein
Sequence: GLLDFALEL
Position: 166-174
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_298
Chemical type: Peptide from protein
Sequence: GLLDFALEL
Position: 166-174
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_889
Chemical type: Peptide from protein
Sequence: LLGSGIYQV
Position: 900-908
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_493
Chemical type: Peptide from protein
Sequence: YVSDTVTFV
Position: 505-513
Source molecule (GenBank): Q9IVZ8.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_493
Chemical type: Peptide from protein
Sequence: YVSDTVTFV
Position: 505-513
Source molecule (GenBank): Q9IVZ8.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1334
Chemical type: Peptide from protein
Sequence: SLAKFIPTI
Position: 1335-1343
Source molecule (GenBank): A0A0S2EGK3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_339
Chemical type: Peptide from protein
Sequence: RLMTYLRGI
Position: 339-347
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_343
Chemical type: Peptide from protein
Sequence: YLRGISYKV
Position: 343-351
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_154
Chemical type: Peptide from protein
Sequence: VLYAAPLNPL
Position: 154-163
Source molecule (GenBank): Q1AHU7.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_37
Chemical type: Peptide from protein
Sequence: FLSRVQTEI
Position: 37-45
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_235
Chemical type: Peptide from protein
Sequence: ILRAWIRTTK
Position: 235-244
Source molecule (GenBank): Q9IVZ9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_409
Chemical type: Peptide from protein
Sequence: RLYSWLFEK
Position: 409-417
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_409
Chemical type: Peptide from protein
Sequence: RLYSWLFEK
Position: 409-417
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1299
Chemical type: Peptide from protein
Sequence: RMAAPSQRK
Position: 1295-1303
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_300
Chemical type: Peptide from protein
Sequence: SLFPSACSTK
Position: 300-309
Source molecule (GenBank): Q9IVZ9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_343
Chemical type: Peptide from protein
Sequence: TTAATRFMK
Position: 211-219
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_342
Chemical type: Peptide from protein
Sequence: TTTAATRFMK
Position: 210-219
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_534
Chemical type: Peptide from protein
Sequence: KTFYVLPLR
Position: 546-554
Source molecule (GenBank): Q9IVZ8.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_75
Chemical type: Peptide from protein
Sequence: RPRQAPRPL
Position: 75-83
Source molecule (GenBank): Q80IY5.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF3_8
Chemical type: Peptide from protein
Sequence: SPMGSPCAL
Position: 8-16
Source molecule (GenBank): A0A7L5ULR8.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_602
Chemical type: Peptide from protein
Sequence: APHSALAAL
Position: 614-622
Source molecule (GenBank): Q9IVZ8.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1302
Chemical type: Peptide from protein
Sequence: APSQRKAVL
Position: 1298-1306
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF3_34
Chemical type: Peptide from protein
Sequence: RPASRLAAV
Position: 25-33
Source molecule (GenBank): Q6J8G1.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_181
Chemical type: Peptide from protein
Sequence: HGMTRLYAA
Position: 181-189
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_127
Chemical type: Peptide from protein
Sequence: AANCRRSAL
Position: 127-135
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_189
Chemical type: Peptide from protein
Sequence: RATIRYRPL
Position: 57-65
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_650
Chemical type: Peptide from protein
Sequence: SALYRYNRF
Position: 650-658
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_895
Chemical type: Peptide from protein
Sequence: YQVPVGLSF
Position: 902-910
Source molecule (GenBank): A0A411PZ15.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_244
Chemical type: Peptide from protein
Sequence: LVIPSERLHY
Position: 112-121
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_340
Chemical type: Peptide from protein
Sequence: LMTYLRGISY
Position: 340-349
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_435
Chemical type: Peptide from protein
Sequence: RRWLSAGFHL
Position: 435-444
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_435
Chemical type: Peptide from protein
Sequence: RRWLSAGF
Position: 435-442
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_435
Chemical type: Peptide from protein
Sequence: RRWLSAGFH
Position: 435-443
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1315
Chemical type: Peptide from protein
Sequence: GRYGRRTKLY
Position: 1311-1320
Source molecule (GenBank): Q9WC28.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1_1315
Chemical type: Peptide from protein
Sequence: GRYGRRTKLY
Position: 1311-1320
Source molecule (GenBank): Q9WC28.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1315
Chemical type: Peptide from protein
Sequence: GRYGRRTKLY
Position: 1311-1320
Source molecule (GenBank): Q9WC28.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1315
Chemical type: Peptide from protein
Sequence: GRYGRRTKLY
Position: 1311-1320
Source molecule (GenBank): Q9WC28.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_881
Chemical type: Peptide from protein
Sequence: RRGTAAYPLL
Position: 891-900
Source molecule (GenBank): Q9IVZ9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1009
Chemical type: Peptide from protein
Sequence: RRRGFAAF
Position: 1005-1012
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_170
Chemical type: Peptide from protein
Sequence: WPADVAEAM
Position: 170-178
Source molecule (GenBank): Q9IVZ9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_155
Chemical type: Peptide from protein
Sequence: FAAETGIAL
Position: 155-163
Source molecule (GenBank): B0FYW3.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_887
Chemical type: Peptide from protein
Sequence: YPLLGSGIY
Position: 898-906
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_281
Chemical type: Peptide from protein
Sequence: YPRSTEVY
Position: 281-288
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1535
Chemical type: Peptide from protein
Sequence: MAIIAHCY
Position: 1546-1553
Source molecule (GenBank): Q9YLR1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1484
Chemical type: Peptide from protein
Sequence: MEECGMPQW
Position: 1480-1488
Source molecule (GenBank): P29324.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1077
Chemical type: Peptide from protein
Sequence: RPELAPTSWN
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_177
Chemical type: Peptide from protein
Sequence: TEASNYAQY
Position: 45-53
Source molecule (GenBank): Q00270.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF1_1466
Chemical type: Peptide from protein
Sequence: SEFDSTQNNF
Position: 1462-1471
Source molecule (GenBank): Q81862.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: ORF2_389 V
Chemical type: Peptide from protein
Sequence: SSAGGQVFY
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_389 V
Chemical type: Peptide from protein
Sequence: SSAGGQVFY
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF2_389 V
Chemical type: Peptide from protein
Sequence: SSAGGQVFY
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo