Reference: Saskia C Stein; George Ssebyatika; Tim Benecke; Luisa Ströh; Manoj K Rajak; Benjamin Vollmer; Sarah Menz; Ja-Yun Waldmann; Sarah N Tipp; Okechukwu Ochulor; Elisabeth Herold; Britta Schwarzloh; Doris Mutschall; Jasmin Zischke; Talia Schneider; Imke Hinrichs; Rainer Blasczyk; Hannah Kleine-Weber; Markus Hoffmann; Florian Klein; Franziska K Kaiser; Mariana Gonzalez-Hernandez; Federico Armando; Malgorzata Ciurkiewicz; Georg Beythien; Stefan Pöhlmann; Wolfgang Baumgärtner; Kay Gruenewald; Albert Osterhaus; Thomas F Schulz; Thomas Krey; Guido Hansen. "A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs." mBio (2025).

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00026

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 900000.0

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.13

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00012

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.51

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 500000.0

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of pT1679 Fab on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: Y369, F377, K378, C379, Y380, V382, S383, P384, D405, E406, R408, Q409, P412, G413, Q414, T415, G416, D420, D427
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive