Reference: Ana da Silva Almeida; Melissa L Geddie; Anil Bhate; Chao Quan; Joseph W Arndt; Yang Jiao; Joseph C Santoro; Liron Noiman; Ramya Vijayakumar; Jorge Sanchez-Salazar; Abhishek Datta; Giovanna Antognetti; Ciputra Adijaya Hartana; Xue Fan Wang; Benjamin A Smith; Dan Bartlett; Danté Duncan; Chia-Chen Liu; Karel Otero Gutierrez; Thomas O Cameron; Samir Koirala; Heather A Cooke. "Building a potent TREM2 agonistic, biparatopic, common light chain antibody." mAbs (2025).

Epitope: Epitope of 7411 Fab on TREM2 stalk
Chemical type: Peptide from protein
Sequence: DPLDHRDAGDLWFPGESE
Position: 131-148
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00571

Epitope: Epitope of 7411 Fab on TREM2 stalk
Chemical type: Peptide from protein
Sequence: DPLDHRDAGDLWFPGESE
Position: 131-148
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.7

Epitope: Epitope of 7411 Fab on TREM2 stalk
Chemical type: Peptide from protein
Sequence: DPLDHRDAGDLWFPGESE
Position: 131-148
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 995000.0

Epitope: Epitope of 7411 Fab on TREM2 stalk
Chemical type: Peptide from protein
Sequence: DPLDHRDAGDLWFPGESE
Position: 131-148
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of 7268 Fab on TREM2
Chemical type: Discontinuous protein residues
Discontinuous residues: R52, Q53, L54, G55, E56, P102, H103, A105, G106, L107, V128, A130
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 7268 Fab on TREM2
Chemical type: Discontinuous protein residues
Discontinuous residues: R52, Q53, L54, G55, E56, P102, H103, A105, G106, L107, V128, A130
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 100.2

Epitope: Epitope of 7268 Fab on TREM2
Chemical type: Discontinuous protein residues
Discontinuous residues: R52, Q53, L54, G55, E56, P102, H103, A105, G106, L107, V128, A130
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.7

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 143.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 834000.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.146

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 95.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 41.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 175.5

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 14.6

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1370000.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0199

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 41.0

Epitope: TREM2 stalk
Chemical type: Peptide from protein
Sequence: HRDAGDLWFPGESESFEDAHVEHSISRSLLEGEIPFPPTS
Position: 135-174
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 70.0

Epitope: TREM2 stalk (130-157)
Chemical type: Peptide from protein
Sequence: ADPLDHRDAGDLWFPGESESFEDAHVEH
Position: 130-157
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive

Epitope: TREM2 stalk (130-157)
Chemical type: Peptide from protein
Sequence: ADPLDHRDAGDLWFPGESESFEDAHVEH
Position: 130-157
Source molecule (GenBank): Q9NZC2.1
Assay category: BCell
Result: Positive