Reference: Jaxaira Maggi; Montserrat Carrascal; Lilian Soto; Oscar Neira; María C Cuéllar; Octavio Aravena; Eddie A James; Joaquin Abian; Dolores Jaraquemada; Diego Catalan; Juan C Aguillón. "Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis." Annals of the rheumatic diseases (2022).

Epitope: Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Cit-Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Cit-Alpha-actin-2
Chemical type: Peptide from protein
Sequence: SGGTTMYPGIADRMQKEITA
Position: 300-319
Source molecule (GenBank): P63261.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Cathepsin Z
Chemical type: Peptide from protein
Sequence: SDGTEYWIVRNSWGEPWG
Position: 251-268
Source molecule (GenBank): Q9UBR2.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Cathepsin Z
Chemical type: Peptide from protein
Sequence: SDGTEYWIVRNSWGEPWG
Position: 251-268
Source molecule (GenBank): Q9UBR2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.36

Epitope: Cit-Cathepsin Z
Chemical type: Peptide from protein
Sequence: SDGTEYWIVRNSWGEPWG
Position: 251-268
Source molecule (GenBank): Q9UBR2.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Cathepsin Z
Chemical type: Peptide from protein
Sequence: SDGTEYWIVRNSWGEPWG
Position: 251-268
Source molecule (GenBank): Q9UBR2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.44

Epitope: Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.57

Epitope: Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 8.72

Epitope: Cit-Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.12

Epitope: Cit-Fibronectin
Chemical type: Peptide from protein
Sequence: APITGYRIVYSPSVEGSS
Position: 836-853
Source molecule (GenBank): P02751.5
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Alpha-2-HS-glycoprotein
Chemical type: Peptide from protein
Sequence: SVVYAKCDSSPDSAE
Position: 126-140
Source molecule (GenBank): P02765.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Aminopeptidase N
Chemical type: Peptide from protein
Sequence: INDAFNLASAHKVPV
Position: 662-676
Source molecule (GenBank): P15144.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Annexin A2
Chemical type: Peptide from protein
Sequence: DALNIETAIKTKGVDE
Position: 38-53
Source molecule (GenBank): P07355.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Calreticulin
Chemical type: Peptide from protein
Sequence: GGGYVKLFPNSLDQT
Position: 106-120
Source molecule (GenBank): P27797.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Ceruloplasmin
Chemical type: Peptide from protein
Sequence: VDKEFYLFPTVFDENE
Position: 574-589
Source molecule (GenBank): P00450.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Clusterin
Chemical type: Peptide from protein
Sequence: TVSDNELQEMSNQGSKY
Position: 25-41
Source molecule (GenBank): P10909.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Complement C1q B chain
Chemical type: Peptide from protein
Sequence: HVITNMNNNYEPR
Position: 144-156
Source molecule (GenBank): P02746.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Complement C1r
Chemical type: Peptide from protein
Sequence: GDFRYTTTMGVNTY
Position: 385-398
Source molecule (GenBank): P00736.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Complement C3
Chemical type: Peptide from protein
Sequence: SETRILLQGTPVAQMT
Position: 976-991
Source molecule (GenBank): P01024.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Chaperone BiP
Chemical type: Peptide from protein
Sequence: GVFEVVATNGDTH
Position: 240-252
Source molecule (GenBank): P11021.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Ferritin heavy chain
Chemical type: Peptide from protein
Sequence: DDVALKNFAKYFLHQSHE
Position: 45-62
Source molecule (GenBank): P02794.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Fibrinogen beta chain
Chemical type: Peptide from protein
Sequence: TSEMYLIQPDSSVKPY
Position: 251-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP 90
Chemical type: Peptide from protein
Sequence: KELKIDIIPNPQERT
Position: 69-83
Source molecule (GenBank): P08238.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.23

Epitope: Cit-Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Gelsolin
Chemical type: Peptide from protein
Sequence: DAYVILKTVQLRNGN
Position: 93-107
Source molecule (GenBank): P06396.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 0.74

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 12.75

Epitope: Cit-Histone H2B.d
Chemical type: Peptide from protein
Sequence: MNSFVNDIFERIAGEA
Position: 63-78
Source molecule (GenBank): P62807.4
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50.0

Epitope: Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.57

Epitope: Cit-Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Cit-Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Cit-Proteoglycan 4
Chemical type: Peptide from protein
Sequence: THTIRIQYSPARLA
Position: 1313-1326
Source molecule (GenBank): Q92954.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.04

Epitope: Histone H2A/s
Chemical type: Peptide from protein
Sequence: TAEILELAGNAARDN
Position: 60-74
Source molecule (GenBank): P16104.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H2A/s
Chemical type: Peptide from protein
Sequence: TAEILELAGNAARDN
Position: 60-74
Source molecule (GenBank): P16104.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Histone H4
Chemical type: Peptide from protein
Sequence: DNIQGITKPAIRR
Position: 25-37
Source molecule (GenBank): P62805.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H4
Chemical type: Peptide from protein
Sequence: DNIQGITKPAIRR
Position: 25-37
Source molecule (GenBank): P62805.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H4
Chemical type: Peptide from protein
Sequence: DNIQGITKPAIRR
Position: 25-37
Source molecule (GenBank): P62805.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Histone H4
Chemical type: Peptide from protein
Sequence: DNIQGITKPAIRR
Position: 25-37
Source molecule (GenBank): P62805.2
Assay category: MhcLigandElution
Result: Positive

Epitope: ITI heavy chain H4
Chemical type: Peptide from protein
Sequence: RPSLVPASAENVNK
Position: 323-336
Source molecule (GenBank): Q14624.4
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ITI heavy chain H4
Chemical type: Peptide from protein
Sequence: RPSLVPASAENVNK
Position: 323-336
Source molecule (GenBank): Q14624.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Myeloperoxidase
Chemical type: Peptide from protein
Sequence: SNEIVRFPTDQLTPDQ
Position: 231-246
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Myeloperoxidase
Chemical type: Peptide from protein
Sequence: SNEIVRFPTDQLTPDQ
Position: 231-246
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Myeloperoxidase
Chemical type: Peptide from protein
Sequence: SNEIVRFPTDQLTPDQ
Position: 231-246
Source molecule (GenBank): P05164.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Myeloperoxidase
Chemical type: Peptide from protein
Sequence: SNEIVRFPTDQLTPDQ
Position: 231-246
Source molecule (GenBank): P05164.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Phosphoglycerate kinase 1
Chemical type: Peptide from protein
Sequence: DKIQLINNMLDKV
Position: 219-231
Source molecule (GenBank): P00558.3
Assay category: MhcLigandElution
Result: Positive

Epitope: Plasma alpha-L-fucosidase
Chemical type: Peptide from protein
Sequence: FDPTWESLDARQLPA
Position: 34-48
Source molecule (GenBank): Q9BTY2.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Plasminogen
Chemical type: Peptide from protein
Sequence: HSIFTPETNPRAGL
Position: 513-526
Source molecule (GenBank): P00747.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Protein S100-A4
Chemical type: Peptide from protein
Sequence: DEAAFQKLMSNLDSNR
Position: 51-66
Source molecule (GenBank): P26447.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Protein S100-A9
Chemical type: Peptide from protein
Sequence: IEHIMEDLDTNADKQ
Position: 59-73
Source molecule (GenBank): P06702.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Pyruvate kinase PKM
Chemical type: Peptide from protein
Sequence: ASDPILYRPVAVALDT
Position: 99-114
Source molecule (GenBank): P14618.4
Assay category: MhcLigandElution
Result: Positive

Epitope: Serotransferrin
Chemical type: Peptide from protein
Sequence: TIFENLANKADRDQ
Position: 228-241
Source molecule (GenBank): P02787.5
Assay category: MhcLigandElution
Result: Positive

Epitope: Transthyretin
Chemical type: Peptide from protein
Sequence: IAALLSPYSYSTTAVVTNPK
Position: 127-146
Source molecule (GenBank): P02766.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Vimentin
Chemical type: Peptide from protein
Sequence: VPGVRLLQDSVDFSLADAI
Position: 74-92
Source molecule (GenBank): P08670.4
Assay category: MhcLigandElution
Result: Positive