Reference: Birgit Drabner; Ulrich Reineke; Jens Schneider-Mergener; Robert E Humphreys; Susanne Hartmann; Richard Lucius. "Identification of T helper cell-recognized epitopes in the chitinase of the filarial nematode Onchocerca volvulus." Vaccine (2002).

Epitope: chitinase (19-34)
Chemical type: Peptide from protein
Sequence: AYGYVRGCYYTNWAQY
Position: 19-34
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (35-49)
Chemical type: Peptide from protein
Sequence: RQGEGKFLPEDIPKG
Position: 35-49
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (76-90)
Chemical type: Peptide from protein
Sequence: DTNWSKGMYSRVTKL
Position: 76-90
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (93-107)
Chemical type: Peptide from protein
Sequence: NDPEMKILLSYGGYN
Position: 93-107
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (119-134)
Chemical type: Peptide from protein
Sequence: RAEKRKHFIKSAIAFL
Position: 119-134
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (184-198)
Chemical type: Peptide from protein
Sequence: AVSAGKHTIDQSYNV
Position: 184-198
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (249-263)
Chemical type: Peptide from protein
Sequence: NYWLSKGMPKQKIII
Position: 249-263
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (255-269)
Chemical type: Peptide from protein
Sequence: GMPKQKIIIGIPTYG
Position: 255-269
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (274-288)
Chemical type: Peptide from protein
Sequence: LRDSSKTTIGAEGIS
Position: 274-288
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (295-309)
Chemical type: Peptide from protein
Sequence: TNPAGGTAAYWEICK
Position: 295-309
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (304-318)
Chemical type: Peptide from protein
Sequence: YWEICKYLKEGGKET
Position: 304-318
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (318-332)
Chemical type: Peptide from protein
Sequence: TIDEQGVGACMVQGS
Position: 318-332
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (339-353)
Chemical type: Peptide from protein
Sequence: NEETIRMKMRWLKEK
Position: 339-353
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (343-357)
Chemical type: Peptide from protein
Sequence: IRMKMRWLKEKGYGG
Position: 343-357
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (348-362)
Chemical type: Peptide from protein
Sequence: RWLKEKGYGGAFIWT
Position: 348-362
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (352-366)
Chemical type: Peptide from protein
Sequence: EKGYGGAFIWTLDFD
Position: 352-366
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (395-409)
Chemical type: Peptide from protein
Sequence: TTRSLRTTITQSSTI
Position: 395-409
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (423-437)
Chemical type: Peptide from protein
Sequence: ITKNNKIKTTTIAVE
Position: 423-437
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (456-470)
Chemical type: Peptide from protein
Sequence: HPNDCHLFIHCAHDH
Position: 456-470
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (460-474)
Chemical type: Peptide from protein
Sequence: CHLFIHCAHDHPYVK
Position: 460-474
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (480-494)
Chemical type: Peptide from protein
Sequence: TFFNDKIKVCDHFGE
Position: 480-494
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (113-127)
Chemical type: Peptide from protein
Sequence: FTAIRNRAEKRKHFI
Position: 113-127
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (125-139)
Chemical type: Peptide from protein
Sequence: HFIKSAIAFLRKNKF
Position: 125-139
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (76-88)
Chemical type: Peptide from protein
Sequence: DTNWSKGMYSRVT
Position: 76-88
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (81-93)
Chemical type: Peptide from protein
Sequence: KGMYSRVTKLKEN
Position: 81-93
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (260-272)
Chemical type: Peptide from protein
Sequence: KIIIGIPTYGRGW
Position: 260-272
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (420-432)
Chemical type: Peptide from protein
Sequence: ASEITKNNKIKTT
Position: 420-432
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (451-463)
Chemical type: Peptide from protein
Sequence: FGLFRHPNDCHLF
Position: 451-463
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (462-474)
Chemical type: Peptide from protein
Sequence: LFIHCAHDHPYVK
Position: 462-474
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (44-58)
Chemical type: Peptide from protein
Sequence: EDIPKGLCTHILYAF
Position: 44-58
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (222-237)
Chemical type: Peptide from protein
Sequence: NVDLHAKLHPTKGETS
Position: 222-237
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (38-52)
Chemical type: Peptide from protein
Sequence: EGKFLPEDIPKGLCT
Position: 38-52
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (222-236)
Chemical type: Peptide from protein
Sequence: NVDLHAKLHPTKGET
Position: 222-236
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (247-261)
Chemical type: Peptide from protein
Sequence: AANYWLSKGMPKQKI
Position: 247-261
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (301-315)
Chemical type: Peptide from protein
Sequence: TAAYWEICKYLKEGG
Position: 301-315
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (340-354)
Chemical type: Peptide from protein
Sequence: EETIRMKMRWLKEKG
Position: 340-354
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (39-51)
Chemical type: Peptide from protein
Sequence: GKFLPEDIPKGLC
Position: 39-51
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (219-231)
Chemical type: Peptide from protein
Sequence: WEMNVDLHAKLHP
Position: 219-231
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (224-236)
Chemical type: Peptide from protein
Sequence: DLHAKLHPTKGET
Position: 224-236
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Negative
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (244-256)
Chemical type: Peptide from protein
Sequence: TEFAANYWLSKGM
Position: 244-256
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (302-314)
Chemical type: Peptide from protein
Sequence: AAYWEICKYLKEG
Position: 302-314
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (341-353)
Chemical type: Peptide from protein
Sequence: ETIRMKMRWLKEK
Position: 341-353
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive-High
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: chitinase (221-236)
Chemical type: Peptide from protein
Sequence: MNVDLHAKLHPTKGET
Position: 221-236
Source molecule (GenBank): AAB68960.1
Assay category: TCell
Result: Positive
Host:  8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo