Reference: H M Emranul Haque; Monir Ejemel; David J Vance; Graham Willsey; Michael J Rudolph; Lisa A Cavacini; Yang Wang; Nicholas J Mantis; David D Weis. "Human B Cell Epitope Map of the Lyme Disease Vaccine Antigen, OspA." ACS infectious diseases (2022).

Epitope: Epitope of mAbs 221-11 and 221-20 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRL
Position: 104-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAbs 221-11 and 221-20 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRL
Position: 104-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 33.0

Epitope: Epitope of mAbs 221-11 and 221-20 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRL
Position: 104-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 46.0

Epitope: Epitope of mAbs 221-11 and 221-20 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRL
Position: 104-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAbs 221-11 and 221-20 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRL
Position: 104-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 857-2 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEK
Position: 104-135
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.65

Epitope: Epitope of mAb 857-2 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEK
Position: 104-135
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 857-2 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEK
Position: 104-135
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 857-2 on OspA
Chemical type: Peptide from protein
Sequence: EDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEK
Position: 104-135
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAbs 227-1 and 227-2 on OspA
Chemical type: Peptide from protein
Sequence: KGEVSEKIITRADGTRL
Position: 129-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.7

Epitope: Epitope of mAbs 227-1 and 227-2 on OspA
Chemical type: Peptide from protein
Sequence: KGEVSEKIITRADGTRL
Position: 129-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.6

Epitope: Epitope of mAbs 227-1 and 227-2 on OspA
Chemical type: Peptide from protein
Sequence: KGEVSEKIITRADGTRL
Position: 129-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAbs 227-1 and 227-2 on OspA
Chemical type: Peptide from protein
Sequence: KGEVSEKIITRADGTRL
Position: 129-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAbs 227-1 and 227-2 on OspA
Chemical type: Peptide from protein
Sequence: KGEVSEKIITRADGTRL
Position: 129-145
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 212-55 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171, I262, T263, K264, L265, D266, E267, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 212-55 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171, I262, T263, K264, L265, D266, E267, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.43

Epitope: Epitope of mAb 212-55 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171, I262, T263, K264, L265, D266, E267, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 319-28 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Negative

Epitope: Epitope of mAb 319-28 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.2

Epitope: Epitope of mAb 319-28 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: D141, G142, T143, R144, L145, E146, Y147, T148, G149, I150, K151, S152, D153, G154, S155, G156, K157, K159, V161, L162, K163, G164, Y165, V166, L167, E168, G169, T170, L171
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 319-44 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: E240, N241, T242, I243, T244, V245, Q246, Q247, Y248, D249, S250, N251, G252, T253, K254, L255, E256, G257, S258, A259, V260, E261, I262, T263, K264, L265, D266, E267, I268, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 319-44 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: E240, N241, T242, I243, T244, V245, Q246, Q247, Y248, D249, S250, N251, G252, T253, K254, L255, E256, G257, S258, A259, V260, E261, I262, T263, K264, L265, D266, E267, I268, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 83.0

Epitope: Epitope of mAb 319-44 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: E240, N241, T242, I243, T244, V245, Q246, Q247, Y248, D249, S250, N251, G252, T253, K254, L255, E256, G257, S258, A259, V260, E261, I262, T263, K264, L265, D266, E267, I268, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb LA-2 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: L201, N202, T204, D205, S206, S207, A208, A209, T210, K211, K212, T213, A214, A215, W216, N217, S218, G219, T220, S221, T222, I225, T226, V227, N228, S229, K230, K231, T232, K233, D234, V236, F237, E240, N241, T242, I243, T244, V245, Q246, Q247, Y248, D249, S250, N251, G252, T253, K254, L255, E256, G257, S258, A259, V260, E261, I262, T263, K264, L265, D266, E267, I268, K269, N270, A271, K273
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 3-24 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: L201, N202, T204, D205, S206, S207, A208, A209, T210, K211, K212, T213, A214, A215, W216, N217, S218, G219, T220, S221, T222
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive
Quantitative measurement: 7.27

Epitope: Epitope of mAb 3-24 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: L201, N202, T204, D205, S206, S207, A208, A209, T210, K211, K212, T213, A214, A215, W216, N217, S218, G219, T220, S221, T222
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb 3-24 on OspA
Chemical type: Discontinuous protein residues
Discontinuous residues: L201, N202, T204, D205, S206, S207, A208, A209, T210, K211, K212, T213, A214, A215, W216, N217, S218, G219, T220, S221, T222
Source molecule (GenBank): P0CL66.1
Assay category: BCell
Result: Positive