Reference: Alexandra A Abu-Shmais; Gray Freeman; Adrian Creanga; Matthew J Vukovich; Tek Malla; Grace E Mantus; Geoffrey D Shimberg; Rebecca A Gillespie; Vanessa Guerra Canedo; Bernadeta Dadonaite; Megan D Rodgers; Ankita J Chopde; Elizabeth Bardwil-Lugones; Tatsiana Bylund; Amy R Henry; Jesmine Roberts-Torres; Timothy S Johnston; Sarah Smith; Eun Sung Yang; Cheng Cheng; Emma L Walker; Michelle Ravichandran; Ingelise J Gordon; Tejaswi S Dittakavi; Douglas S Reed; Theodore C Pierson; Lesia Dropulic; Jesse D Bloom; Yaroslav Tsybovsky; Eli A Boritz; Daniel C Douek; Tongqing Zhou; Masaru Kanekiyo; Sarah F Andrews. "Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses." Nature microbiology (2025).

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 326-366.26 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, K69, D84, E85, I87, R88, P90, E91, H126, E128, Y153, Q154, R161, V273
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 100.0

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 50.0

Epitope: Epitope of Fab 310-1H02 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: S144, L145, V147, A149, A150, P152, G155, A156, P157, N205, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5.0

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 326-289.74 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: K64, P65, D84, E85, I87, R88, V89, P90, R161, Y270, Y287, H289
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 100.0

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.1

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-7D11 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: D84, E85, I87, R88, Q131, I132, K135, S136, S137, R161, E267, Y268
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 50.0

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 10.0

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive
Quantitative measurement: 50.0

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab 310-12D03 on HA H5
Chemical type: Discontinuous protein residues
Discontinuous residues: E142, S144, L145, V147, S148, A149, G155, W165, I167, N170, D171, N205, Q234, N236, G237, Q238
Source molecule (GenBank): WYN03019.1
Assay category: BCell
Result: Positive