Reference: Smita S Chandran; Jiaqi Ma; Martin G Klatt; Friederike Dündar; Chaitanya Bandlamudi; Pedram Razavi; Hannah Y Wen; Britta Weigelt; Paul Zumbo; Si Ning Fu; Lauren B Banks; Fei Yi; Enric Vercher; Inaki Etxeberria; Watchain D Bestman; Arnaud Da Cruz Paula; Ilinca S Aricescu; Alexander Drilon; Doron Betel; David A Scheinberg; Brian M Baker; Christopher A Klebanoff. "Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA." Nature medicine (2022).

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.04

Epitope: WT PIK3CA
Chemical type: Peptide from protein
Sequence: AHHGGWTTK
Position: 1046-1054
Source molecule (GenBank): P42336.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 38.7

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Quantitative measurement: 2.12

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Quantitative measurement: 3.11

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Quantitative measurement: 49000.0

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Quantitative measurement: 200000.0

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Engineered

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcLigandElution
Result: Positive

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcLigandElution
Result: Positive

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 55.6

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.12

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.11

Epitope: PIK3CA (H1047L)
Chemical type: Peptide, no natural source
Sequence: ALHGGWTTK
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.96

Epitope: VIAEAIRKK
Chemical type: Peptide from protein
Sequence: VIAEAIRKK
Position: 220-228
Source molecule (GenBank): P42336.2
Assay category: MhcLigandElution
Result: Positive

Epitope: KVIEPVGNR
Chemical type: Peptide from protein
Sequence: KVIEPVGNR
Position: 100-108
Source molecule (GenBank): P42336.2
Assay category: MhcLigandElution
Result: Positive

Epitope: YMNGETSTK
Chemical type: Peptide from protein
Sequence: YMNGETSTK
Position: 317-325
Source molecule (GenBank): P42336.2
Assay category: MhcLigandElution
Result: Positive