Reference: Sarah Lanning; Nayeli Aguilar-Hernández; Vitor Hugo B Serrão; Tomás López; Sara M O'Rourke; Adam Lentz; Lena Ricemeyer; Rafaela Espinosa; Susana López; Carlos F Arias; Rebecca M DuBois. "Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization." Journal of virology (2025).

Epitope: Epitope of 4B6 scFv on hAstV-2 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: H146, D147, N148, N149, D150, G151, V152
Source molecule (GenBank): ART30134.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.67
Host:  8 weeks

Epitope: Epitope of 4B6 scFv on hAstV-2 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: H146, D147, N148, N149, D150, G151, V152
Source molecule (GenBank): ART30134.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 4B6 scFv on hAstV-2 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: H146, D147, N148, N149, D150, G151, V152
Source molecule (GenBank): ART30134.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 4B6 scFv on hAstV-2 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: H146, D147, N148, N149, D150, G151, V152
Source molecule (GenBank): ART30134.1
Assay category: BCell
Result: Positive
Quantitative measurement: 161.0
Host:  8 weeks

Epitope: Epitope of 4B6 scFv on hAstV-2 spike
Chemical type: Discontinuous protein residues
Discontinuous residues: H146, D147, N148, N149, D150, G151, V152
Source molecule (GenBank): ART30134.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 3B4 Fab on hAstV-1 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y557, A559, S560, A561, T562, T567, N568, L570, G573, D574, T575, Y576, T577, T613, N614; D: Y557, S560, T562, G563, A565
Source molecule (GenBank): AAC34717.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 3B4 Fab on hAstV-1 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y557, A559, S560, A561, T562, T567, N568, L570, G573, D574, T575, Y576, T577, T613, N614; D: Y557, S560, T562, G563, A565
Source molecule (GenBank): AAC34717.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 3B4 Fab on hAstV-1 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y557, A559, S560, A561, T562, T567, N568, L570, G573, D574, T575, Y576, T577, T613, N614; D: Y557, S560, T562, G563, A565
Source molecule (GenBank): AAC34717.1
Assay category: BCell
Result: Positive-Intermediate
Host:  8 weeks

Epitope: Epitope of 3B4 Fab on hAstV-1 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y557, A559, S560, A561, T562, T567, N568, L570, G573, D574, T575, Y576, T577, T613, N614; D: Y557, S560, T562, G563, A565
Source molecule (GenBank): AAC34717.1
Assay category: BCell
Result: Positive
Host:  8 weeks

Epitope: Epitope of 3B4 Fab on hAstV-1 spike
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y557, A559, S560, A561, T562, T567, N568, L570, G573, D574, T575, Y576, T577, T613, N614; D: Y557, S560, T562, G563, A565
Source molecule (GenBank): AAC34717.1
Assay category: BCell
Result: Positive
Quantitative measurement: 11.8
Host:  8 weeks