Reference: M Peakman; E J Stevens; T Lohmann; P Narendran; J Dromey; A Alexander; A J Tomlinson; M Trucco; J C Gorga; R M Chicz. "Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4." The Journal of clinical investigation (1999).

Epitope: IA-2 (656-670)
Chemical type: Peptide from protein
Sequence: SVSSQFSDAAQASPS
Position: 656-670
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (655-669)
Chemical type: Peptide from protein
Sequence: SSVSSQFSDAAQASP
Position: 655-669
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (656-674)
Chemical type: Peptide from protein
Sequence: SVSSQFSDAAQASPSSHSS
Position: 656-674
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (652-675)
Chemical type: Peptide from protein
Sequence: SRVSSVSSQFSDAAQASPSSHSST
Position: 652-675
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (656-679)
Chemical type: Peptide from protein
Sequence: SVSSQFSDAAQASPSSHSSTPSWC
Position: 656-679
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (657-680)
Chemical type: Peptide from protein
Sequence: VSSQFSDAAQASPSSHSSTPSWCE
Position: 657-680
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (718-730)
Chemical type: Peptide from protein
Sequence: AYQAEPNTCATAQ
Position: 718-730
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (716-731)
Chemical type: Peptide from protein
Sequence: LCAYQAEPNTCATAQG
Position: 716-731
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (709-725)
Chemical type: Peptide from protein
Sequence: LAKEWQALCAYQAEPNT
Position: 709-725
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (718-736)
Chemical type: Peptide from protein
Sequence: AYQAEPNTCATAQGEGNIK
Position: 718-736
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (713-730)
Chemical type: Peptide from protein
Sequence: WQALCAYQAEPNTCATAQ
Position: 713-730
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (754-765)
Chemical type: Peptide from protein
Sequence: KVESSPSRSDYI
Position: 754-765
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (752-768)
Chemical type: Peptide from protein
Sequence: KLKVESSPSRSDYINAS
Position: 752-768
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (754-775)
Chemical type: Peptide from protein
Sequence: KVESSPSRSDYINASPIIEHDP
Position: 754-775
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (802-815)
Chemical type: Peptide from protein
Sequence: GCTVIVMLTPLVED
Position: 802-815
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (803-816)
Chemical type: Peptide from protein
Sequence: CTVIVMLTPLVEDG
Position: 803-816
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (797-812)
Chemical type: Peptide from protein
Sequence: MVWESGCTVIVMLTPL
Position: 797-812
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (800-817)
Chemical type: Peptide from protein
Sequence: ESGCTVIVMLTPLVEDGV
Position: 800-817
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (795-810)
Chemical type: Peptide from protein
Sequence: WQMVWESGCTVIVMLT
Position: 795-810
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (793-810)
Chemical type: Peptide from protein
Sequence: DFWQMVWESGCTVIVMLT
Position: 793-810
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (794-813)
Chemical type: Peptide from protein
Sequence: FWQMVWESGCTVIVMLTPLV
Position: 794-813
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (861-872)
Chemical type: Peptide from protein
Sequence: TQETRTLTQFHF
Position: 861-872
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (855-867)
Chemical type: Peptide from protein
Sequence: YLKNVQTQETRTL
Position: 855-867
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (856-870)
Chemical type: Peptide from protein
Sequence: LKNVQTQETRTLTQF
Position: 856-870
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (855-869)
Chemical type: Peptide from protein
Sequence: YLKNVQTQETRTLTQ
Position: 855-869
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (857-871)
Chemical type: Peptide from protein
Sequence: KNVQTQETRTLTQFH
Position: 857-871
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (853-871)
Chemical type: Peptide from protein
Sequence: SFYLKNVQTQETRTLTQFH
Position: 853-871
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (957-969)
Chemical type: Peptide from protein
Sequence: DQFEFALTAVAEE
Position: 957-969
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (957-973)
Chemical type: Peptide from protein
Sequence: DQFEFALTAVAEEVNAI
Position: 957-973
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (959-976)
Chemical type: Peptide from protein
Sequence: FEFALTAVAEEVNAILKA
Position: 959-976
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (955-972)
Chemical type: Peptide from protein
Sequence: SKDQFEFALTAVAEEVNA
Position: 955-972
Source molecule (GenBank): NP_002837.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IA-2 (654-674)
Chemical type: Peptide from protein
Sequence: VSSQFSDAAQASPSSHSS
Position: 657-674
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Negative
MHC allele types: 63
Host:  16-36 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (654-674)
Chemical type: Peptide from protein
Sequence: VSSQFSDAAQASPSSHSS
Position: 657-674
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive
MHC allele types: 63 406 408
Host:  6-42 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (654-674)
Chemical type: Peptide from protein
Sequence: VSSQFSDAAQASPSSHSS
Position: 657-674
Source molecule (GenBank): Q16849.1
Assay category: MhcBinding
Result: Positive-High

Epitope: IA-2 (709-732)
Chemical type: Peptide from protein
Sequence: LAKEWQALCAYQAEPNTCATAQG
Position: 709-731
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Negative
MHC allele types: 63
Host:  16-36 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (709-732)
Chemical type: Peptide from protein
Sequence: LAKEWQALCAYQAEPNTCATAQG
Position: 709-731
Source molecule (GenBank): Q16849.1
Assay category: TCell
Result: Positive
MHC allele types: 63 406 408
Host:  6-42 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (709-732)
Chemical type: Peptide from protein
Sequence: LAKEWQALCAYQAEPNTCATAQG
Position: 709-731
Source molecule (GenBank): Q16849.1
Assay category: MhcBinding
Result: Positive-High

Epitope: IA-2 (753-771)
Chemical type: Peptide from protein
Sequence: LKVESSPSRSDYINASPII
Position: 753-771
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Negative
MHC allele types: 63
Host:  16-36 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (753-771)
Chemical type: Peptide from protein
Sequence: LKVESSPSRSDYINASPII
Position: 753-771
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Negative
MHC allele types: 63 406 408
Host:  6-42 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (753-771)
Chemical type: Peptide from protein
Sequence: LKVESSPSRSDYINASPII
Position: 753-771
Source molecule (GenBank): NP_002837.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: IA-2 (854-872)
Chemical type: Peptide from protein
Sequence: FYLKNVQTQETRTLTQFHF
Position: 854-872
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Positive
MHC allele types: 63 406 408
Host:  6-42 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (854-872)
Chemical type: Peptide from protein
Sequence: FYLKNVQTQETRTLTQFHF
Position: 854-872
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Negative
MHC allele types: 63
Host:  16-36 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (854-872)
Chemical type: Peptide from protein
Sequence: FYLKNVQTQETRTLTQFHF
Position: 854-872
Source molecule (GenBank): NP_002837.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: IA-2 (955-975)
Chemical type: Peptide from protein
Sequence: SKDQFEFALTAVAEEVNAILK
Position: 955-975
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Positive
MHC allele types: 63 406 408
Host:  6-42 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (955-975)
Chemical type: Peptide from protein
Sequence: SKDQFEFALTAVAEEVNAILK
Position: 955-975
Source molecule (GenBank): NP_002837.1
Assay category: TCell
Result: Negative
MHC allele types: 63
Host:  16-36 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: IA-2 (955-975)
Chemical type: Peptide from protein
Sequence: SKDQFEFALTAVAEEVNAILK
Position: 955-975
Source molecule (GenBank): NP_002837.1
Assay category: MhcBinding
Result: Positive-Low