Reference: Benjamin Vollmer; Henriette Ebel; Renate Rees; Julia Nentwig; Thomas Mulvaney; Jürgen Schünemann; Jens Krull; Maya Topf; Dirk Görlich; Kay Grünewald. "A nanobody specific to prefusion glycoprotein B neutralizes HSV-1 and HSV-2." Nature (2025).

Epitope: Epitope of Nb1_gbHSV on HSV1 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G121, D285, E286, G292, F294, Y296, H311, T312, S313, Y314, A315, D317, R318, P348, K349; B: N585, Y640, Y649, E651, A654, Y655, S656, H657, Q658, D663
Source molecule (GenBank): A1Z0P7
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV1 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G121, D285, E286, G292, F294, Y296, H311, T312, S313, Y314, A315, D317, R318, P348, K349; B: N585, Y640, Y649, E651, A654, Y655, S656, H657, Q658, D663
Source molecule (GenBank): A1Z0P7
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV1 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G121, D285, E286, G292, F294, Y296, H311, T312, S313, Y314, A315, D317, R318, P348, K349; B: N585, Y640, Y649, E651, A654, Y655, S656, H657, Q658, D663
Source molecule (GenBank): A1Z0P7
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV1 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G121, D285, E286, G292, F294, Y296, H311, T312, S313, Y314, A315, D317, R318, P348, K349; B: N585, Y640, Y649, E651, A654, Y655, S656, H657, Q658, D663
Source molecule (GenBank): A1Z0P7
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV1 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: G121, D285, E286, G292, F294, Y296, H311, T312, S313, Y314, A315, D317, R318, P348, K349; B: N585, Y640, Y649, E651, A654, Y655, S656, H657, Q658, D663
Source molecule (GenBank): A1Z0P7
Assay category: BCell
Result: Positive
Quantitative measurement: 0.014
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV2 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: V101, N582, Y637, Y646, E648, A651, Y652, S653, H654, Q655; C: G116, D280, E281, G287, F289, Y291, H306, T307, S308, Y309, A310, R313, P343
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV2 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: V101, N582, Y637, Y646, E648, A651, Y652, S653, H654, Q655; C: G116, D280, E281, G287, F289, Y291, H306, T307, S308, Y309, A310, R313, P343
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV2 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: V101, N582, Y637, Y646, E648, A651, Y652, S653, H654, Q655; C: G116, D280, E281, G287, F289, Y291, H306, T307, S308, Y309, A310, R313, P343
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.014
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV2 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: V101, N582, Y637, Y646, E648, A651, Y652, S653, H654, Q655; C: G116, D280, E281, G287, F289, Y291, H306, T307, S308, Y309, A310, R313, P343
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Nb1_gbHSV on HSV2 prefusion gB
Chemical type: Region on multi-chain protein
Discontinuous residues: A: V101, N582, Y637, Y646, E648, A651, Y652, S653, H654, Q655; C: G116, D280, E281, G287, F289, Y291, H306, T307, S308, Y309, A310, R313, P343
Source molecule (GenBank): P08666.2
Assay category: BCell
Result: Positive
Host: F