Reference: Nilufer P Seth; Rui Xu; Matthew DuPrie; Amit Choudhury; Samuel Sihapong; Steven Tyler; James Meador; William Avery; Edward Cochran; Thomas Daly; Julia Brown; Laura Rutitzky; Lynn Markowitz; Sujatha Kumar; Traymon Beavers; Sayak Bhattacharya; Hsin Chen; Viraj Parge; Karen Price; Yang Wang; Siddharth Sukumaran; Yvonne Pao; Katie Abouzahr; Fiona Elwood; Jay Duffner; Sucharita Roy; Pushpa Narayanaswami; Jonathan J Hubbard; Leona E Ling. "Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties." mAbs (2025).

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000118

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Negative

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.41

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0578

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1280000.0

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000742

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.058

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2030000.0

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Negative

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nipocalimab Fab on FcRn
Chemical type: Region on multi-chain protein
Discontinuous residues: A: L105, G106, G107, K108, G109, Y111, L135, N136, G152, D153, W154, P155, E156, L158, A159, Q162; B: I21, Q22, V105
Source molecule (GenBank): P55899.1
Assay category: BCell
Result: Positive