Reference: Hadi Karimzadeh; Muthamia M Kiraithe; Anna D Kosinska; Manuel Glaser; Melanie Fiedler; Valerie Oberhardt; Elahe Salimi Alizei; Maike Hofmann; Juk Yee Mok; Melanie Nguyen; Wim J E van Esch; Bettina Budeus; Jan Grabowski; Maria Homs; Antonella Olivero; Hossein Keyvani; Francisco Rodríguez-Frías; David Tabernero; Maria Buti; Andreas Heinold; Seyed Moayed Alavian; Tanja Bauer; Julian Schulze Zur Wiesch; Bijan Raziorrouh; Daniel Hoffmann; Antonina Smedile; Mario Rizzetto; Heiner Wedemeyer; Jörg Timm; Iris Antes; Christoph Neumann-Haefelin; Ulrike Protzer; Michael Roggendorf. "Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8<sup>+</sup> T Cells." Journal of virology (2018).

Epitope: L-HDAg 75-83
Chemical type: Peptide from protein
Sequence: RTDQMEVDS
Position: 77-85
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 94-102
Chemical type: Peptide from protein
Sequence: FTDKERQHD
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 43-51
Chemical type: Peptide from protein
Sequence: KLEEDNPWL
Position: 43-51
Source molecule (GenBank): P25989.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 143-152
Chemical type: Peptide from protein
Sequence: RVAGPPVGGV
Position: 145-154
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 198-206
Chemical type: Peptide from protein
Sequence: ILFPSDPPF
Position: 198-206
Source molecule (GenBank): P25880.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 198-206
Chemical type: Peptide from protein
Sequence: ILFPSDPPF
Position: 198-206
Source molecule (GenBank): P25880.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 53-61
Chemical type: Peptide from protein
Sequence: NIKGILGKK
Position: 55-63
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 89-97
Chemical type: Peptide from protein
Sequence: PLRGGFTDK
Position: 91-99
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 49-57
Chemical type: Peptide from protein
Sequence: PWLGNIKGI
Position: 51-59
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 68-76
Chemical type: Peptide from protein
Sequence: APPAKRART
Position: 70-78
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 71-79
Chemical type: Peptide from protein
Sequence: AKRARTDQM
Position: 73-81
Source molecule (GenBank): CAA44973.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 168–176
Chemical type: Peptide from protein
Sequence: VPSMQGVPE
Position: 168-176
Source molecule (GenBank): P25989.1
Assay category: MhcBinding
Result: Negative

Epitope: L-HDAg 103–112
Chemical type: Peptide from protein
Sequence: RRRKALENKK
Position: 103-112
Source molecule (GenBank): CAJ66091.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L-HDAg 103–112
Chemical type: Peptide from protein
Sequence: RRRKALENKK
Position: 103-112
Source molecule (GenBank): CAJ66091.1
Assay category: MhcBinding
Result: Positive-High

Epitope: CTELKLSDY
Chemical type: Peptide from protein
Sequence: CTELKLSDY
Position: 44-52
Source molecule (GenBank): AAA43467.1
Assay category: MhcBinding
Result: Positive

Epitope: CTELKLSDY
Chemical type: Peptide from protein
Sequence: CTELKLSDY
Position: 44-52
Source molecule (GenBank): AAA43467.1
Assay category: MhcBinding
Result: Negative

Epitope: NPKASLLSL
Chemical type: Peptide from protein
Sequence: NPKASLLSL
Position: 306-314
Source molecule (GenBank): AEQ63625.1
Assay category: MhcBinding
Result: Negative

Epitope: NPKASLLSL
Chemical type: Peptide from protein
Sequence: NPKASLLSL
Position: 306-314
Source molecule (GenBank): AEQ63625.1
Assay category: MhcBinding
Result: Negative

Epitope: NPKASLLSL
Chemical type: Peptide from protein
Sequence: NPKASLLSL
Position: 306-314
Source molecule (GenBank): AEQ63625.1
Assay category: MhcBinding
Result: Positive

Epitope: NLVPMVATV
Chemical type: Peptide from protein
Sequence: NLVPMVATV
Position: 485-493
Source molecule (GenBank): AAA45994.1
Assay category: MhcBinding
Result: Positive

Epitope: NLVPMVATV
Chemical type: Peptide from protein
Sequence: NLVPMVATV
Position: 485-493
Source molecule (GenBank): AAA45994.1
Assay category: MhcBinding
Result: Negative

Epitope: LIYRRRLMK
Chemical type: Peptide from protein
Sequence: LIYRRRLMK
Position: 614-622
Source molecule (GenBank): AAB19181.1
Assay category: MhcBinding
Result: Positive

Epitope: LIYRRRLMK
Chemical type: Peptide from protein
Sequence: LIYRRRLMK
Position: 614-622
Source molecule (GenBank): AAB19181.1
Assay category: MhcBinding
Result: Negative

Epitope: LYSACFWWL
Chemical type: Peptide from protein
Sequence: LYSACFWWL
Position: 126-134
Source molecule (GenBank): NP_000264.2
Assay category: MhcBinding
Result: Positive

Epitope: IVTDFSVIK
Chemical type: Peptide from protein
Sequence: IVTDFSVIK
Position: 416-424
Source molecule (GenBank): CAA24858.1
Assay category: MhcBinding
Result: Negative

Epitope: KRWIILGLNK
Chemical type: Peptide from protein
Sequence: KRWIILGLNK
Position: 256-265
Source molecule (GenBank): Q1KW74.1
Assay category: MhcBinding
Result: Positive

Epitope: A1
Chemical type: Peptide from protein
Sequence: MSRSESRKNRGGREEL
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A2
Chemical type: Peptide from protein
Sequence: SRSESRKNRGGREELL
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A3
Chemical type: Peptide from protein
Sequence: RGGREELLEQWVAGRK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: A4
Chemical type: Peptide from protein
Sequence: EQWVAGRKKLEELERD
Position: 18-33
Source molecule (GenBank): P29997.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: B5
Chemical type: Peptide from protein
Sequence: KLEELERDLRKTKKKL
Position: 26-41
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: B7
Chemical type: Peptide from protein
Sequence: KKIEDENPWLGNIKGI
Position: 42-57
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: B8
Chemical type: Peptide from protein
Sequence: WLGNIKGILGKKDKDG
Position: 50-65
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C9
Chemical type: Peptide from protein
Sequence: LGKKDKDGEGAPPAKR
Position: 58-73
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C10
Chemical type: Peptide from protein
Sequence: EGAPPAKRARTDQMEV
Position: 66-81
Source molecule (GenBank): ABO87233.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C10a
Chemical type: Peptide from protein
Sequence: EGAPPAKRARTDRMEV
Position: 66-81
Source molecule (GenBank): P25880.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: C11
Chemical type: Peptide from protein
Sequence: ARTDQMEVDSGPGKRP
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: D11a
Chemical type: Peptide from protein
Sequence: ARTDRMEVDSGPGKRP
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: D12
Chemical type: Peptide from protein
Sequence: DSGPGKRPLRGGFTDK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: D13
Chemical type: Peptide from protein
Sequence: LRGGFTDKERRDHRRR
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: D14
Chemical type: Peptide from protein
Sequence: ERRDHRRRKALENKKK
Position: 98-113
Source molecule (GenBank): CAJ66091.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E15
Chemical type: Peptide from protein
Sequence: KALVNKKKQLSAGGKN
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E17
Chemical type: Peptide from protein
Sequence: LSKEEEEELRRLTEED
Position: 122-137
Source molecule (GenBank): P29997.2
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: E18
Chemical type: Peptide from protein
Sequence: LRRLTEEDERRERRVA
Position: 130-145
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: F19
Chemical type: Peptide from protein
Sequence: ERRERRVAGPPVGGVN
Position: 138-153
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: F20
Chemical type: Peptide from protein
Sequence: GPPVGGVNPLEGGSRG
Position: 146-161
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: F21
Chemical type: Peptide from protein
Sequence: PLEGGSRGAPGGGFVP
Position: 154-169
Source molecule (GenBank): AAG26087.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: F22
Chemical type: Peptide from protein
Sequence: APGGGFVPNLQGVPES
Position: 162-177
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: G23
Chemical type: Peptide from protein
Sequence: NLQGVPESPFSRTGEG
Position: 170-185
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: G24
Chemical type: Peptide from protein
Sequence: PFSRTGEGLDIRGNQG
Position: 178-193
Source molecule (GenBank): AAA45723.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: H25
Chemical type: Peptide from protein
Sequence: LDIRGNQGFPQDTLFP
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: H26
Chemical type: Peptide from protein
Sequence: FPQDTLFPADPPLSPQ
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: H27
Chemical type: Peptide from protein
Sequence: LFPADPPLSPQSCRPQ
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: KLEDENPWL
Chemical type: Peptide from protein
Sequence: KLEDENPWL
Position: 43-51
Source molecule (GenBank): AAG26087.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: L-HDAg 104–112
Chemical type: Peptide from protein
Sequence: RRKALENKK
Position: 104-112
Source molecule (GenBank): CAJ66091.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RRKKALENKK
Chemical type: Peptide from protein
Sequence: RRKKALENKK
Position: 102-111
Source molecule (GenBank): ABO87189.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RRRMALENKK
Chemical type: Peptide from protein
Sequence: RRRMALENKK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RKKALENKK
Chemical type: Peptide from protein
Sequence: RKKALENKK
Position: 103-111
Source molecule (GenBank): ABO87189.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RRMALENKK
Chemical type: Peptide from protein
Sequence: RRMALENKK
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RQDHRRRKAL
Chemical type: Peptide from protein
Sequence: RQDHRRRKAL
Position: 99-108
Source molecule (GenBank): AAG26087.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RQDHRRRKAL
Chemical type: Peptide from protein
Sequence: RQDHRRRKAL
Position: 99-108
Source molecule (GenBank): AAG26087.1
Assay category: MhcBinding
Result: Positive

Epitope: RQDHRRKKAL
Chemical type: Peptide from protein
Sequence: RQDHRRKKAL
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RRDHRRKKAL
Chemical type: Peptide from protein
Sequence: RRDHRRKKAL
Position: 98-107
Source molecule (GenBank): ABO87189.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RRDHRRKKAL
Chemical type: Peptide from protein
Sequence: RRDHRRKKAL
Position: 98-107
Source molecule (GenBank): ABO87189.1
Assay category: MhcBinding
Result: Positive

Epitope: RKDHRRRKAL
Chemical type: Peptide from protein
Sequence: RKDHRRRKAL
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: RKDHRRRKAL
Chemical type: Peptide from protein
Sequence: RKDHRRRKAL
Assay category: MhcBinding
Result: Positive

Epitope: REDHRRRKAL
Chemical type: Peptide from protein
Sequence: REDHRRRKAL
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: REDHRRRKAL
Chemical type: Peptide from protein
Sequence: REDHRRRKAL
Assay category: MhcBinding
Result: Positive

Epitope: RQDHRRRMAL
Chemical type: Peptide from protein
Sequence: RQDHRRRMAL
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated