Reference: Rinee Mukherjee; Danielle Wagar; Tracey A Stephens; Edwin Lee-Chan; Bhagirath Singh. "Identification of CD4+ T cell-specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein: a novel beta cell autoantigen in type 1 diabetes." Journal of immunology (Baltimore, Md. : 1950) (2005).

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P1
Chemical type: Peptide from protein
Sequence: TAALSYTISRMEESSVTL
Position: 128-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P2
Chemical type: Peptide from protein
Sequence: LHRSGVLIIHHLQEDYRTY
Position: 4-22
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P3
Chemical type: Peptide from protein
Sequence: WYVMVTAALSYTISRMEESSVTL
Position: 123-145
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P4
Chemical type: Peptide from protein
Sequence: FAGLVRNLGVLFGLGFAIN
Position: 256-274
Source molecule (GenBank): NP_066999.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P4
Chemical type: Peptide from protein
Sequence: FAGLVRNLGVLFGLGFAIN
Position: 256-274
Source molecule (GenBank): NP_066999.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P4
Chemical type: Peptide from protein
Sequence: FAGLVRNLGVLFGLGFAIN
Position: 256-274
Source molecule (GenBank): NP_066999.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P5
Chemical type: Peptide from protein
Sequence: MFLRSCQGENGTKPSFRL
Position: 277-294
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P5
Chemical type: Peptide from protein
Sequence: MFLRSCQGENGTKPSFRL
Position: 277-294
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P5
Chemical type: Peptide from protein
Sequence: MFLRSCQGENGTKPSFRL
Position: 277-294
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P6
Chemical type: Peptide from protein
Sequence: QFPTTCETGPGSPSGHAMGSS
Position: 100-120
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P6
Chemical type: Peptide from protein
Sequence: QFPTTCETGPGSPSGHAMGSS
Position: 100-120
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P6
Chemical type: Peptide from protein
Sequence: QFPTTCETGPGSPSGHAMGSS
Position: 100-120
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Negative
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: P7
Chemical type: Peptide from protein
Sequence: HTPGVHMASLSVYLKTNVFL
Position: 195-214
Source molecule (GenBank): NP_067306.1
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Positive
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Positive
Host: F 
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Positive
Host: F 4 weeks

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Insulin B Chain B:9-23
Chemical type: Peptide from protein
Sequence: SHLVEALYLVAGERG
Assay category: TCell
Result: Negative
Host: F 4 weeks
Cell type: T cell CD4+
Tissue: lymph node
Culture conditions: Direct Ex Vivo

Epitope: Proinsulin 1
Chemical type: Peptide from protein
Sequence: FFYTPKSRREVED
Position: 48-60
Source molecule (GenBank): NP_032412.3
Assay category: TCell
Result: Positive-Low
Host: F 4 weeks