Reference: Vamsee Mallajosyula; Conner Ganjavi; Saborni Chakraborty; Alana M McSween; Ana Jimena Pavlovitch-Bedzyk; Julie Wilhelmy; Allison Nau; Monali Manohar; Kari C Nadeau; Mark M Davis. "CD8<sup>+</sup> T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients." Science immunology (2021).

Epitope: ORF1ab P1
Chemical type: Peptide from protein
Sequence: VMVELVAEL
Position: 84-92
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P1
Chemical type: Peptide from protein
Sequence: VMVELVAEL
Position: 84-92
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P1
Chemical type: Peptide from protein
Sequence: VMVELVAEL
Position: 84-92
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P2
Chemical type: Peptide from protein
Sequence: TLGVLVPHV
Position: 103-111
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P2
Chemical type: Peptide from protein
Sequence: TLGVLVPHV
Position: 103-111
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P2
Chemical type: Peptide from protein
Sequence: TLGVLVPHV
Position: 103-111
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P3
Chemical type: Peptide from protein
Sequence: YLATALLTL
Position: 1675-1683
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P3
Chemical type: Peptide from protein
Sequence: YLATALLTL
Position: 1675-1683
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P3
Chemical type: Peptide from protein
Sequence: YLATALLTL
Position: 1675-1683
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P4
Chemical type: Peptide from protein
Sequence: SLPGVFCGV
Position: 3013-3021
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P4
Chemical type: Peptide from protein
Sequence: SLPGVFCGV
Position: 3013-3021
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P4
Chemical type: Peptide from protein
Sequence: SLPGVFCGV
Position: 3013-3021
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P5
Chemical type: Peptide from protein
Sequence: VLAWLYAAV
Position: 3467-3475
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P5
Chemical type: Peptide from protein
Sequence: VLAWLYAAV
Position: 3467-3475
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P5
Chemical type: Peptide from protein
Sequence: VLAWLYAAV
Position: 3467-3475
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P6
Chemical type: Peptide from protein
Sequence: FLNRFTTTL
Position: 3482-3490
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P6
Chemical type: Peptide from protein
Sequence: FLNRFTTTL
Position: 3482-3490
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P6
Chemical type: Peptide from protein
Sequence: FLNRFTTTL
Position: 3482-3490
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P7
Chemical type: Peptide from protein
Sequence: TLMNVLTLV
Position: 3710-3718
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P7
Chemical type: Peptide from protein
Sequence: TLMNVLTLV
Position: 3710-3718
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P7
Chemical type: Peptide from protein
Sequence: TLMNVLTLV
Position: 3710-3718
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P8
Chemical type: Peptide from protein
Sequence: SMWALIISV
Position: 3732-3740
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P8
Chemical type: Peptide from protein
Sequence: SMWALIISV
Position: 3732-3740
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P8
Chemical type: Peptide from protein
Sequence: SMWALIISV
Position: 3732-3740
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P9
Chemical type: Peptide from protein
Sequence: VLLSVLQQL
Position: 3871-3879
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P9
Chemical type: Peptide from protein
Sequence: VLLSVLQQL
Position: 3871-3879
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P9
Chemical type: Peptide from protein
Sequence: VLLSVLQQL
Position: 3871-3879
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P10
Chemical type: Peptide from protein
Sequence: MLFTMLRKL
Position: 4032-4040
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P10
Chemical type: Peptide from protein
Sequence: MLFTMLRKL
Position: 4032-4040
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P10
Chemical type: Peptide from protein
Sequence: MLFTMLRKL
Position: 4032-4040
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P11
Chemical type: Peptide from protein
Sequence: ALWEIQQVV
Position: 4094-4102
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P11
Chemical type: Peptide from protein
Sequence: ALWEIQQVV
Position: 4094-4102
Source molecule (GenBank): P0DTC1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P11
Chemical type: Peptide from protein
Sequence: ALWEIQQVV
Position: 4094-4102
Source molecule (GenBank): P0DTC1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P12
Chemical type: Peptide from protein
Sequence: TMADLVYAL
Position: 4515-4523
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P12
Chemical type: Peptide from protein
Sequence: TMADLVYAL
Position: 4515-4523
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P12
Chemical type: Peptide from protein
Sequence: TMADLVYAL
Position: 4515-4523
Source molecule (GenBank): P0DTD1.1
Assay category: MhcBinding
Result: Positive

Epitope: ORF1ab P13
Chemical type: Peptide from protein
Sequence: IFVDGVPFV
Position: 4725-4733
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P13
Chemical type: Peptide from protein
Sequence: IFVDGVPFV
Position: 4725-4733
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: ORF1ab P13
Chemical type: Peptide from protein
Sequence: IFVDGVPFV
Position: 4725-4733
Source molecule (GenBank): P0DTD1.1
Assay category: MhcBinding
Result: Positive

Epitope: S P14
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P14
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P14
Chemical type: Peptide from protein
Sequence: YLQPRTFLL
Position: 269-277
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive

Epitope: S P15
Chemical type: Peptide from protein
Sequence: KIADYNYKL
Position: 417-425
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P15
Chemical type: Peptide from protein
Sequence: KIADYNYKL
Position: 417-425
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P15
Chemical type: Peptide from protein
Sequence: KIADYNYKL
Position: 417-425
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive

Epitope: S P16
Chemical type: Peptide from protein
Sequence: SIIAYTMSL
Position: 691-699
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P16
Chemical type: Peptide from protein
Sequence: SIIAYTMSL
Position: 691-699
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P16
Chemical type: Peptide from protein
Sequence: SIIAYTMSL
Position: 691-699
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive

Epitope: S P17
Chemical type: Peptide from protein
Sequence: VLNDILSRL
Position: 976-984
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P17
Chemical type: Peptide from protein
Sequence: VLNDILSRL
Position: 976-984
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P17
Chemical type: Peptide from protein
Sequence: VLNDILSRL
Position: 976-984
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive

Epitope: S P19
Chemical type: Peptide from protein
Sequence: FIAGLIAIV
Position: 1220-1228
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P19
Chemical type: Peptide from protein
Sequence: FIAGLIAIV
Position: 1220-1228
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: S P19
Chemical type: Peptide from protein
Sequence: FIAGLIAIV
Position: 1220-1228
Source molecule (GenBank): P0DTC2.1
Assay category: MhcBinding
Result: Positive

Epitope: M P20
Chemical type: Peptide from protein
Sequence: KLLEQWNLV
Position: 15-23
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P20
Chemical type: Peptide from protein
Sequence: KLLEQWNLV
Position: 15-23
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P20
Chemical type: Peptide from protein
Sequence: KLLEQWNLV
Position: 15-23
Source molecule (GenBank): P0DTC5.1
Assay category: MhcBinding
Result: Positive

Epitope: M P21
Chemical type: Peptide from protein
Sequence: FLFLTWICL
Position: 26-34
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P21
Chemical type: Peptide from protein
Sequence: FLFLTWICL
Position: 26-34
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P21
Chemical type: Peptide from protein
Sequence: FLFLTWICL
Position: 26-34
Source molecule (GenBank): P0DTC5.1
Assay category: MhcBinding
Result: Positive

Epitope: M P22
Chemical type: Peptide from protein
Sequence: TLACFVLAA
Position: 61-69
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P22
Chemical type: Peptide from protein
Sequence: TLACFVLAA
Position: 61-69
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P22
Chemical type: Peptide from protein
Sequence: TLACFVLAA
Position: 61-69
Source molecule (GenBank): P0DTC5.1
Assay category: MhcBinding
Result: Positive

Epitope: M P23
Chemical type: Peptide from protein
Sequence: GLMWLSYFI
Position: 89-97
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P23
Chemical type: Peptide from protein
Sequence: GLMWLSYFI
Position: 89-97
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: M P23
Chemical type: Peptide from protein
Sequence: GLMWLSYFI
Position: 89-97
Source molecule (GenBank): P0DTC5.1
Assay category: MhcBinding
Result: Positive

Epitope: N P24
Chemical type: Peptide from protein
Sequence: LLLDRLNQL
Position: 222-230
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N P24
Chemical type: Peptide from protein
Sequence: LLLDRLNQL
Position: 222-230
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N P24
Chemical type: Peptide from protein
Sequence: LLLDRLNQL
Position: 222-230
Source molecule (GenBank): P0DTC9.1
Assay category: MhcBinding
Result: Positive

Epitope: N P25
Chemical type: Peptide from protein
Sequence: GMSRIGMEV
Position: 316-324
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N P25
Chemical type: Peptide from protein
Sequence: GMSRIGMEV
Position: 316-324
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: N P25
Chemical type: Peptide from protein
Sequence: GMSRIGMEV
Position: 316-324
Source molecule (GenBank): P0DTC9.1
Assay category: MhcBinding
Result: Positive

Epitope: HKU1 ORF1ab P1
Chemical type: Peptide from protein
Sequence: VIVDKVGEL
Position: 6668-6676
Source molecule (GenBank): ADN03337.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HKU1 ORF1ab P5
Chemical type: Peptide from protein
Sequence: VIAWLYAAI
Position: 3538-3546
Source molecule (GenBank): P0C6U3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: OC43 ORF1ab P10
Chemical type: Peptide from protein
Sequence: MLFSMVRKL
Position: 4016-4024
Source molecule (GenBank): P0C6X6
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: OC43 ORF1ab P12
Chemical type: Peptide from protein
Sequence: TMLDLCYAL
Position: 4492-4500
Source molecule (GenBank): P0C6X6
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: OC43 S P17
Chemical type: Peptide from protein
Sequence: SLQEILSRL
Position: 1057-1065
Source molecule (GenBank): Q0ZME7.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: BHW58
Chemical type: Peptide from protein
Sequence: WLDGVTPSL
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: pp65
Chemical type: Peptide from protein
Sequence: NLVPMVATV
Position: 485-493
Source molecule (GenBank): AAA45994.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: pp65
Chemical type: Peptide from protein
Sequence: NLVPMVATV
Position: 485-493
Source molecule (GenBank): AAA45994.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HA
Chemical type: Peptide from protein
Sequence: PKYVKQNTLKLAT
Position: 306-318
Source molecule (GenBank): AAA43143.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Cell Line / Clone