Reference: Zhuoqian Zhao; Qi Yang; Xiaoce Liu; Mengfei Li; Yinkai Duan; Mingjuan Du; Anqi Zhou; Huanzhen Liu; Yujia He; Wei Wang; Yuchi Lu; Xiaoyu Zhang; Haofeng Wang; Xiuna Yang; Hongkai Zhang; Xinwen Chen; Zihe Rao; Haitao Yang. "The crystal structure of coronavirus RBD-TMPRSS2 complex provides basis for the discovery of therapeutic antibodies." Nature communications (2025).

Epitope: Epitope of R7 scFv on HCoV-HKU1
Chemical type: Discontinuous protein residues
Discontinuous residues: Y465, C466, T508, V509, L510, W515, R517, L521, P522, I525, T526, A527, Y528, D529, P530, R531, K537, S538, L539
Source molecule (GenBank): Q5MQD0.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of R7 scFv on HCoV-HKU1
Chemical type: Discontinuous protein residues
Discontinuous residues: Y465, C466, T508, V509, L510, W515, R517, L521, P522, I525, T526, A527, Y528, D529, P530, R531, K537, S538, L539
Source molecule (GenBank): Q5MQD0.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.65

Epitope: Epitope of R7 scFv on HCoV-HKU1
Chemical type: Discontinuous protein residues
Discontinuous residues: Y465, C466, T508, V509, L510, W515, R517, L521, P522, I525, T526, A527, Y528, D529, P530, R531, K537, S538, L539
Source molecule (GenBank): Q5MQD0.1
Assay category: BCell
Result: Positive

Epitope: Epitope of R7 scFv on HCoV-HKU1
Chemical type: Discontinuous protein residues
Discontinuous residues: Y465, C466, T508, V509, L510, W515, R517, L521, P522, I525, T526, A527, Y528, D529, P530, R531, K537, S538, L539
Source molecule (GenBank): Q5MQD0.1
Assay category: BCell
Result: Positive

Epitope: Epitope of T22 scFv on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: H296, K342, E388, E389, K390, G391, K392, D435, S436, C437, Q438, S441, T459, S460, W461, G462, G464, C465, K467, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 1.9

Epitope: Epitope of T22 scFv on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: H296, K342, E388, E389, K390, G391, K392, D435, S436, C437, Q438, S441, T459, S460, W461, G462, G464, C465, K467, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.2

Epitope: Epitope of T22 scFv on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: H296, K342, E388, E389, K390, G391, K392, D435, S436, C437, Q438, S441, T459, S460, W461, G462, G464, C465, K467, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH77 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, N277, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, Y322, K342, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.64

Epitope: Epitope of VHH77 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, N277, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, Y322, K342, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.0

Epitope: Epitope of VHH77 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, N277, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, Y322, K342, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive

Epitope: Epitope of VHH77-10 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, K342, D345, K390, T393, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.68

Epitope: Epitope of VHH77-10 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, K342, D345, K390, T393, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive
Quantitative measurement: 2.0

Epitope: Epitope of VHH77-10 on TMPRSS2
Chemical type: Discontinuous protein residues
Discontinuous residues: V275, Q276, V278, H279, V280, H296, C297, K300, P301, L302, N304, W306, H307, K342, D345, K390, T393, D435, S436, C437, Q438, S441, S460, W461, G462, S463, G464, C465, G472
Source molecule (GenBank): O15393.3
Assay category: BCell
Result: Positive