Reference: P Bernasconi-Elias; T Hu; D Jenkins; B Firestone; S Gans; E Kurth; P Capodieci; J Deplazes-Lauber; K Petropoulos; P Thiel; D Ponsel; S Hee Choi; P LeMotte; A London; M Goetcshkes; E Nolin; M D Jones; K Slocum; M J Kluk; D M Weinstock; A Christodoulou; O Weinberg; J Jaehrling; S A Ettenberg; A Buckler; S C Blacklow; J C Aster; C J Fryer. "Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies." Oncogene (2016).

Epitope: Epitope of MOR20350 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: Q1427, C1428, E1429, C1442, P1444, A1445, S1447, S1448, P1449, A1450, Y1453, C1458, G1461, G1462, E1464, L1507, L1508, R1510, L1592, S1594, P1595, E1596, N1597, D1598, H1599, P1602, S1606
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.3

Epitope: Epitope of MOR20350 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: Q1427, C1428, E1429, C1442, P1444, A1445, S1447, S1448, P1449, A1450, Y1453, C1458, G1461, G1462, E1464, L1507, L1508, R1510, L1592, S1594, P1595, E1596, N1597, D1598, H1599, P1602, S1606
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.16

Epitope: Epitope of MOR20350 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: Q1427, C1428, E1429, C1442, P1444, A1445, S1447, S1448, P1449, A1450, Y1453, C1458, G1461, G1462, E1464, L1507, L1508, R1510, L1592, S1594, P1595, E1596, N1597, D1598, H1599, P1602, S1606
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.19

Epitope: Epitope of MOR20350 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: Q1427, C1428, E1429, C1442, P1444, A1445, S1447, S1448, P1449, A1450, Y1453, C1458, G1461, G1462, E1464, L1507, L1508, R1510, L1592, S1594, P1595, E1596, N1597, D1598, H1599, P1602, S1606
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive

Epitope: Epitope of MOR20350 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: Q1427, C1428, E1429, C1442, P1444, A1445, S1447, S1448, P1449, A1450, Y1453, C1458, G1461, G1462, E1464, L1507, L1508, R1510, L1592, S1594, P1595, E1596, N1597, D1598, H1599, P1602, S1606
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive

Epitope: Epitope of MOR20358 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: S1440, R1463, R1465, T1466, C1467, N1468, P1469, V1470, Y1471, E1472, K1473, Y1474, Q1486, G1487, E1492, R1534, E1618, R1619, D1621
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.6

Epitope: Epitope of MOR20358 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: S1440, R1463, R1465, T1466, C1467, N1468, P1469, V1470, Y1471, E1472, K1473, Y1474, Q1486, G1487, E1492, R1534, E1618, R1619, D1621
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.14

Epitope: Epitope of MOR20358 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: S1440, R1463, R1465, T1466, C1467, N1468, P1469, V1470, Y1471, E1472, K1473, Y1474, Q1486, G1487, E1492, R1534, E1618, R1619, D1621
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.1

Epitope: Epitope of MOR20358 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: S1440, R1463, R1465, T1466, C1467, N1468, P1469, V1470, Y1471, E1472, K1473, Y1474, Q1486, G1487, E1492, R1534, E1618, R1619, D1621
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive

Epitope: Epitope of MOR20358 Fab on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: S1440, R1463, R1465, T1466, C1467, N1468, P1469, V1470, Y1471, E1472, K1473, Y1474, Q1486, G1487, E1492, R1534, E1618, R1619, D1621
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive

Epitope: Epitope of mAb A4 on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: A1394, K1395, R1396, D1398, Q1399, R1400, D1402, R1403, E1404, S1420, V1421, G1422, E1576, V1577, I1578, S1615, A1616, R1619, L1620, D1621, F1622, P1625, L1626, R1627
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Host: M

Epitope: Epitope of mAb A4 on NOTCH3 NRR
Chemical type: Discontinuous protein residues
Discontinuous residues: A1394, K1395, R1396, D1398, Q1399, R1400, D1402, R1403, E1404, S1420, V1421, G1422, E1576, V1577, I1578, S1615, A1616, R1619, L1620, D1621, F1622, P1625, L1626, R1627
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive
Host: M

Epitope: NOTCH3 ICD3
Chemical type: Peptide from protein
Sequence: VMVARRK
Position: 1662-1668
Source molecule (GenBank): Q9UM47.2
Assay category: BCell
Result: Positive