Reference: Xueer Zhao; Fan Yang; Filipe Mariz; Wolfram Osen; Angelo Bolchi; Simone Ottonello; Martin Müller. "Combined prophylactic and therapeutic immune responses against human papillomaviruses induced by a thioredoxin-based L2-E7 nanoparticle vaccine." PLoS pathogens (2020).

Epitope: E7 49-57
Chemical type: Peptide from protein
Sequence: RAHYNIVTF
Position: 49-57
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: E7 49-57
Chemical type: Peptide from protein
Sequence: RAHYNIVTF
Position: 49-57
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: E7 49-57
Chemical type: Peptide from protein
Sequence: RAHYNIVTF
Position: 49-57
Source molecule (GenBank): P03129
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVA 257-264
Chemical type: Peptide from protein
Sequence: SIINFEKL
Position: 257-264
Source molecule (GenBank): 0705172A
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVA 257-264
Chemical type: Peptide from protein
Sequence: SIINFEKL
Position: 257-264
Source molecule (GenBank): 0705172A
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVA 257-264
Chemical type: Peptide from protein
Sequence: SIINFEKL
Position: 257-264
Source molecule (GenBank): 0705172A
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: T cell CD8+
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: L2 (20-38)
Chemical type: Peptide from protein
Sequence: KTCKQAGTCPPDIIPKVEG
Position: 20-38
Source molecule (GenBank): ACL12316.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: L2 (20-38)
Chemical type: Peptide from protein
Sequence: KTCKQAGTCPPDIIPKVEG
Position: 20-38
Source molecule (GenBank): ACL12316.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: L2 (20-38)
Chemical type: Peptide from protein
Sequence: KTCKQAGTCPPDIIPKVEG
Position: 20-38
Source molecule (GenBank): ACL12316.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: L2 (20-38)
Chemical type: Peptide from protein
Sequence: KTCKQAGTCPPDIIPKVEG
Position: 20-38
Source molecule (GenBank): ACL12316.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: L2 (20-38)
Chemical type: Peptide from protein
Sequence: KTCKQAGTCPPDIIPKVEG
Position: 20-38
Source molecule (GenBank): ACL12316.1
Assay category: BCell
Result: Negative
Host: F 6-8 weeks

Epitope: OVX313-I5
Chemical type: Peptide from protein
Sequence: VCGEVAYIQSVVSDCHVPTA
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I1
Chemical type: Peptide from protein
Sequence: EVGRQNLIRSKEEILKKLKE
Position: 78-97
Source molecule (GenBank): WP_011011870.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I2
Chemical type: Peptide from protein
Sequence: RSKEEILKKLKELQEGSKKQ
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I3
Chemical type: Peptide from protein
Sequence: KLKELQEGSKKQGDADVCGE
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I4
Chemical type: Peptide from protein
Sequence: SKKQGDADVCGEVAYIQSVV
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I6
Chemical type: Peptide from protein
Sequence: QSVVSDCHVPTAELRTLLEI
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I7
Chemical type: Peptide from protein
Sequence: VPTAELRTLLEIRKLFLEIQ
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I8
Chemical type: Peptide from protein
Sequence: LLEIRKLFLEIQKLKVEGRR
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: OVX313-I9
Chemical type: Peptide from protein
Sequence: RKLFLEIQKLKVEGRRRRRS
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: PADRE
Chemical type: Peptide, no natural source
Sequence: AKFVAAWTLKAAA
Assay category: TCell
Result: Positive-Low
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo