Reference: Maud Sigoillot; Marie Overtus; Magdalena Grodecka; Daniel Scholl; Abel Garcia-Pino; Toon Laeremans; Lihua He; Els Pardon; Ellen Hildebrandt; Ina Urbatsch; Jan Steyaert; John R Riordan; Cedric Govaerts. "Domain-interface dynamics of CFTR revealed by stabilizing nanobodies." Nature communications (2019).

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 1.95

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 37.9

Epitope: Epitope of nanobody T4 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M469, M472, E474, I488, S489, F490, F494, S495, W496, I497, M498, P499, F508, G509, V510, E543, R553, R560, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 54.0

Epitope: Epitope of nanobody T2a on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: G458, S459, G550, G551, G576, Y577, L578, D579, V580, L581, S605, K606, M607, L610, I618, L619, H620, L633
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 2.49

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T27 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: A457, G458, S459, G576, Y577, D579, V580, L581, S605, K606, M607, E608, L610, K611, I618, H620, Y625
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 25.0

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 2.91

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody T8 on CFTR NBD1
Chemical type: Discontinuous protein residues
Discontinuous residues: M472, E474, F490, S492, F494, S495, W496, I497, M498, P499, E504, F508, G509, R553, K564
Source molecule (GenBank): Q20BJ8
Assay category: BCell
Result: Positive
Quantitative measurement: 39.0