Reference: Thierry O Fischmann; Daniel Malashock; Eunseon Ahn; Hongmei Wang; Komal Pradhan; Jeffery Grein; Srishti Chakravorty; Soheila Bahmanjah; David Ban; Ellen Chien; Mark Hsieh; Todd Mayhood; Jing Yuan; Janica C Wong; Maribel Beaumont; Jeanne Baker; Mark A McCoy; Mingmei Cai; Douglas Wilson; Wendy Blumenschein; Sybil M G Williams; Laurence Fayadat-Dilman; Wolfgang Seghezzi; Tanya Keenan; Jin-Hwan Han. "Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy." Journal for immunotherapy of cancer (2025).

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.23

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.13

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00070

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 5400000.0

Epitope: Epitope of vibostolimab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, L65, I68, N70, D72, L73, G74, H76, S78, P79, K82, D83, H111, T112, Y113, P114, D115, G116, T117
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0017

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00026

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1900000.0

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive

Epitope: Epitope of tiragolumab Fab on hTIGIT
Chemical type: Discontinuous protein residues
Discontinuous residues: T55, Q56, N58, E60, Q64, L65, I68, L73, H76, I77, S78, P79, S80, K82, H111
Source molecule (GenBank): Q495A1.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.29