Reference: Andréa Toma; Samy Haddouk; Jean-Paul Briand; Luc Camoin; Hanne Gahery; Francine Connan; Danielle Dubois-Laforgue; Sophie Caillat-Zucman; Jean-Gérard Guillet; Jean-Claude Carel; Sylviane Muller; Jeannine Choppin; Christian Boitard. "Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients." Proceedings of the National Academy of Sciences of the United States of America (2005).

Epitope: Flu A matrix protein 1 (58-66)
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): ABL61489.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A matrix protein 1 (58-66)
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): ABL61489.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A matrix protein 1 (58-66)
Chemical type: Peptide from protein
Sequence: GILGFVFTL
Position: 58-66
Source molecule (GenBank): ABL61489.1
Assay category: MhcBinding
Result: Positive

Epitope: Flu A nucleocapsid protein (44-52)
Chemical type: Peptide from protein
Sequence: CTELKLSDY
Position: 44-52
Source molecule (GenBank): ABL31781.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A nucleocapsid protein (44-52)
Chemical type: Peptide from protein
Sequence: CTELKLSDY
Position: 44-52
Source molecule (GenBank): ABL31781.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A nucleocapsid protein (44-52)
Chemical type: Peptide from protein
Sequence: CTELKLSDY
Position: 44-52
Source molecule (GenBank): ABL31781.1
Assay category: MhcBinding
Result: Positive

Epitope: Flu A nucleocapsid protein (265-273)
Chemical type: Peptide from protein
Sequence: ILRGSVAHK
Position: 265-273
Source molecule (GenBank): ABL31781.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A nucleocapsid protein (265-273)
Chemical type: Peptide from protein
Sequence: ILRGSVAHK
Position: 265-273
Source molecule (GenBank): ABL31781.1
Assay category: MhcBinding
Result: Positive

Epitope: Flu A nucleocapsid protein (380-388)
Chemical type: Peptide from protein
Sequence: ELRSRYWAI
Position: 380-388
Source molecule (GenBank): ABL31781.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A nucleocapsid protein (380-388)
Chemical type: Peptide from protein
Sequence: ELRSRYWAI
Position: 380-388
Source molecule (GenBank): ABL31781.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Flu A nucleocapsid protein (380-388)
Chemical type: Peptide from protein
Sequence: ELRSRYWAI
Position: 380-388
Source molecule (GenBank): ABL31781.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: HIV Nef (83-91)
Chemical type: Peptide from protein
Sequence: AAVDLSHFL
Position: 83-91
Source molecule (GenBank): ACR27130.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIV Nef (83-91)
Chemical type: Peptide from protein
Sequence: AAVDLSHFL
Position: 83-91
Source molecule (GenBank): ACR27130.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIV Nef (83-91)
Chemical type: Peptide from protein
Sequence: AAVDLSHFL
Position: 83-91
Source molecule (GenBank): ACR27130.1
Assay category: MhcBinding
Result: Negative

Epitope: HIV Nef (121-128)
Chemical type: Peptide from protein
Sequence: FPDWQNYT
Position: 121-128
Source molecule (GenBank): P04324.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIV Nef (121-128)
Chemical type: Peptide from protein
Sequence: FPDWQNYT
Position: 121-128
Source molecule (GenBank): P04324.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIV Nef (121-128)
Chemical type: Peptide from protein
Sequence: FPDWQNYT
Position: 121-128
Source molecule (GenBank): P04324.3
Assay category: MhcBinding
Result: Negative

Epitope: Insulin precursor (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (34-42)
Chemical type: Peptide from protein
Sequence: HLVEALYLV
Position: 34-42
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (41-50)
Chemical type: Peptide from protein
Sequence: LVCGERGFFY
Position: 41-50
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (49-57)
Chemical type: Peptide from protein
Sequence: FYTPKTRRE
Position: 49-57
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin precursor (28-57)
Chemical type: Peptide from protein
Sequence: QHLCGSHLVEALYLVCGERGFFYTPKTRRE
Position: 28-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (28-57)
Chemical type: Peptide from protein
Sequence: QHLCGSHLVEALYLVCGERGFFYTPKTRRE
Position: 28-57
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (30-39)
Chemical type: Peptide from protein
Sequence: LCGSHLVEAL
Position: 30-39
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (38-46)
Chemical type: Peptide from protein
Sequence: ALYLVCGER
Position: 38-46
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin precursor (39-48)
Chemical type: Peptide from protein
Sequence: LYLVCGERGF
Position: 39-48
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (39-48)
Chemical type: Peptide from protein
Sequence: LYLVCGERGF
Position: 39-48
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (39-48)
Chemical type: Peptide from protein
Sequence: LYLVCGERGF
Position: 39-48
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (39-48)
Chemical type: Peptide from protein
Sequence: LYLVCGERGF
Position: 39-48
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin precursor (41-51)
Chemical type: Peptide from protein
Sequence: LVCGERGFFYT
Position: 41-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (42-51)
Chemical type: Peptide from protein
Sequence: VCGERGFFYT
Position: 42-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Insulin precursor (44-51)
Chemical type: Peptide from protein
Sequence: GERGFFYT
Position: 44-51
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Insulin precursor (45-53)
Chemical type: Peptide from protein
Sequence: ERGFFYTPK
Position: 45-53
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (45-53)
Chemical type: Peptide from protein
Sequence: ERGFFYTPK
Position: 45-53
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (45-53)
Chemical type: Peptide from protein
Sequence: ERGFFYTPK
Position: 45-53
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Positive
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (45-53)
Chemical type: Peptide from protein
Sequence: ERGFFYTPK
Position: 45-53
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Intermediate

Epitope: Insulin precursor (50-58)
Chemical type: Peptide from protein
Sequence: YTPKTRREA
Position: 50-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Insulin precursor (51-58)
Chemical type: Peptide from protein
Sequence: TPKTRREA
Position: 51-58
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Negative

Epitope: Insulin precursor (51-61)
Chemical type: Peptide from protein
Sequence: TPKTRREAEDL
Position: 51-61
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (51-61)
Chemical type: Peptide from protein
Sequence: TPKTRREAEDL
Position: 51-61
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  35-45 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (51-61)
Chemical type: Peptide from protein
Sequence: TPKTRREAEDL
Position: 51-61
Source molecule (GenBank): P01308.1
Assay category: TCell
Result: Negative
Host:  21-59 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Insulin precursor (51-61)
Chemical type: Peptide from protein
Sequence: TPKTRREAEDL
Position: 51-61
Source molecule (GenBank): P01308.1
Assay category: MhcBinding
Result: Positive-Low