Reference: Mei-Ling Yang; Sheryl Horstman; Renelle Gee; Perrin Guyer; TuKiet T Lam; Jean Kanyo; Ana L Perdigoto; Cate Speake; Carla J Greenbaum; Aïsha Callebaut; Lut Overbergh; Richard G Kibbey; Kevan C Herold; Eddie A James; Mark J Mamula. "Citrullination of glucokinase is linked to autoimmune diabetes." Nature communications (2022).

Epitope: Glucokinase 17-31
Chemical type: Peptide from protein
Sequence: EQILAEFQLQEEDLK
Position: 17-31
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 44-58
Chemical type: Peptide from protein
Sequence: GLRLETHEEASVKML
Position: 44-58
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 54-68
Chemical type: Peptide from protein
Sequence: SVKMLPTYVRSTPEG
Position: 54-68
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 71-85
Chemical type: Peptide from protein
Sequence: VGDFLSLDLGGTNFR
Position: 71-85
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 81-95
Chemical type: Peptide from protein
Sequence: GTNFRVMLVKVGEGE
Position: 81-95
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 15300.0

Epitope: Glucokinase 83-98
Chemical type: Peptide from protein
Sequence: NFRVMLVKVGEGEEG
Position: 83-97
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 120-134
Chemical type: Peptide from protein
Sequence: EMLFDYISECISDFL
Position: 120-134
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 40100.0

Epitope: Glucokinase 145-159
Chemical type: Peptide from protein
Sequence: PLGFTFSFPVRHEDI
Position: 145-159
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 168-182
Chemical type: Peptide from protein
Sequence: TKGFKASGAEGNNVV
Position: 168-182
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 199-214
Chemical type: Peptide from protein
Sequence: VVAMVNDTVATMISCY
Position: 199-214
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive
Host:  30-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 199-214
Chemical type: Peptide from protein
Sequence: VVAMVNDTVATMISCY
Position: 199-214
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive-Low
Host:  30-65 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 199-214
Chemical type: Peptide from protein
Sequence: VVAMVNDTVATMISCY
Position: 199-214
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2500.0

Epitope: Glucokinase 222-236
Chemical type: Peptide from protein
Sequence: VGMIVGTGCNACYME
Position: 222-236
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 240-254
Chemical type: Peptide from protein
Sequence: NVELVEGDEGRMCVN
Position: 240-254
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 248-262
Chemical type: Peptide from protein
Sequence: EGRMCVNTEWGAFGD
Position: 248-262
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 250-264
Chemical type: Peptide from protein
Sequence: RMCVNTEWGAFGDSG
Position: 250-264
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 254-268
Chemical type: Peptide from protein
Sequence: NTEWGAFGDSGELDE
Position: 254-268
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 257-271
Chemical type: Peptide from protein
Sequence: WGAFGDSGELDEFLL
Position: 257-271
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 266-280
Chemical type: Peptide from protein
Sequence: LDEFLLEYDRLVDES
Position: 266-280
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive-Low
Host:  30-65 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 266-280
Chemical type: Peptide from protein
Sequence: LDEFLLEYDRLVDES
Position: 266-280
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive
Host:  30-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 266-280
Chemical type: Peptide from protein
Sequence: LDEFLLEYDRLVDES
Position: 266-280
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 5600.0

Epitope: Glucokinase 270-284
Chemical type: Peptide from protein
Sequence: LLEYDRLVDESSANP
Position: 270-284
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive-Low
Host:  30-65 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 270-284
Chemical type: Peptide from protein
Sequence: LLEYDRLVDESSANP
Position: 270-284
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive
Host:  30-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 270-284
Chemical type: Peptide from protein
Sequence: LLEYDRLVDESSANP
Position: 270-284
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2000.0

Epitope: Glucokinase 274-288
Chemical type: Peptide from protein
Sequence: DRLVDESSANPGQQL
Position: 274-288
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 286-300
Chemical type: Peptide from protein
Sequence: QQLYEKLIGGKYMGE
Position: 286-300
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 294-308
Chemical type: Peptide from protein
Sequence: GGKYMGELVRLVLLR
Position: 294-308
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 4300.0

Epitope: Glucokinase 306-320
Chemical type: Peptide from protein
Sequence: LLRLVDENLLFHGEA
Position: 306-320
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 311-324
Chemical type: Peptide from protein
Sequence: DENLLFHGEASEQL
Position: 311-324
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 313-327
Chemical type: Peptide from protein
Sequence: NLLFHGEASEQLRTR
Position: 313-327
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 327-341
Chemical type: Peptide from protein
Sequence: RGAFETRFVSQVESD
Position: 327-341
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 331-344
Chemical type: Peptide from protein
Sequence: ETRFVSQVESDTGD
Position: 331-344
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 346-360
Chemical type: Peptide from protein
Sequence: KQIYNILSTLGLRPS
Position: 346-360
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive-Low
Host:  30-65 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 346-360
Chemical type: Peptide from protein
Sequence: KQIYNILSTLGLRPS
Position: 346-360
Source molecule (GenBank): P35557.1
Assay category: TCell
Result: Positive
Host:  30-57 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Glucokinase 346-360
Chemical type: Peptide from protein
Sequence: KQIYNILSTLGLRPS
Position: 346-360
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 470.0

Epitope: Glucokinase 349-363
Chemical type: Peptide from protein
Sequence: YNILSTLGLRPSTTD
Position: 349-363
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 365-378
Chemical type: Peptide from protein
Sequence: DIVRRACESVSTRA
Position: 365-378
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 387-401
Chemical type: Peptide from protein
Sequence: AGVINRMRESRSEDV
Position: 387-401
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 398-412
Chemical type: Peptide from protein
Sequence: SEDVMRITVGVDGSV
Position: 398-412
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 410-424
Chemical type: Peptide from protein
Sequence: GSVYKLHPSFKERFH
Position: 410-424
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 416-439
Chemical type: Peptide from protein
Sequence: HPSFKERFHASVRRL
Position: 416-430
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: Glucokinase 435-449
Chemical type: Peptide from protein
Sequence: EITFIESEEGSGRGA
Position: 435-449
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: deca-citrullinated peptide
Chemical type: Peptide, no natural source
Sequence: RRRRRRRRRRGGC
Assay category: BCell
Result: Positive

Epitope: deca-citrullinated peptide
Chemical type: Peptide, no natural source
Sequence: RRRRRRRRRRGGC
Assay category: BCell
Result: Positive

Epitope: Glucokinase 270- CIT
Chemical type: Peptide from protein
Sequence: LLEYDRLVDESSANP
Position: 270-284
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 8600.0

Epitope: Glucokinase 346- CIT
Chemical type: Peptide from protein
Sequence: KQIYNILSTLGLRPS
Position: 346-360
Source molecule (GenBank): P35557.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 540.0