Reference: Xinlei Zhuang; Zhe Wang; Jiansheng Fan; Xuefei Bai; Yingchun Xu; James J Chou; Tingjun Hou; Shuqing Chen; Liqiang Pan. "Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance." Nature communications (2022).

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.03821

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.09512

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 168000.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 141000.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00076

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.56

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.01292

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.009611

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00818

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00555

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000729

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.397

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 77100.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00028

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.29

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00027

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.43

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.79

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.6

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 108000.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000878

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 110000.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.25

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 57700.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000262

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 82000.0

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000307

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of cetuximab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, V374, R377, L406, Q408, Q432, H433, Q435, F436, V441, S442, I462, S464, G465, K467, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of panitumumab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, Q408, H433, V441, S442, I462, S464, G465, K467, T488, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.02108

Epitope: Epitope of panitumumab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, Q408, H433, V441, S442, I462, S464, G465, K467, T488, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of panitumumab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, Q408, H433, V441, S442, I462, S464, G465, K467, T488, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of panitumumab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, Q408, H433, V441, S442, I462, S464, G465, K467, T488, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive

Epitope: Epitope of panitumumab on wild-type EGFR
Chemical type: Discontinuous protein residues
Discontinuous residues: P373, Q408, H433, V441, S442, I462, S464, G465, K467, T488, K489, I490, I491, S492, N493, G495, N497
Source molecule (GenBank): P00533.2
Assay category: BCell
Result: Positive