Reference: Jet van den Dijssel; Mariël C Duurland; Veronique Al Konijn; Laura Yl Kummer; Ruth R Hagen; Lisan H Kuijper; Luuk Wieske; Koos Pj van Dam; Eileen W Stalman; Maurice Steenhuis; Dionne M Geerdes; Juk Yee Mok; Angela Hm Kragten; Charlotte Menage; Lianne Koets; Barbera Veldhuisen; Niels Jm Verstegen; C Ellen van der Schoot; Wim Je van Esch; Geert Ram D'Haens; Mark Löwenberg; Adriaan G Volkers; Theo Rispens; Taco W Kuijpers; Filip Eftimov; Klaas Pjm van Gisbergen; S Marieke van Ham; Anja Ten Brinke; Carolien E van de Sandt. "mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8<sup>+</sup> T cell responses." Journal of autoimmunity (2024).

Epitope: SARS-CoV-2  ORF1ab1321
Chemical type: Peptide from protein
Sequence: PTDNYITTY
Position: 1321-1329
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2  ORF1ab1321
Chemical type: Peptide from protein
Sequence: PTDNYITTY
Position: 1321-1329
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab1637
Chemical type: Peptide from protein
Sequence: TTDPSFLGRY
Position: 1637-1646
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab1637
Chemical type: Peptide from protein
Sequence: TTDPSFLGRY
Position: 1637-1646
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a207
Chemical type: Peptide from protein
Sequence: FTSDYYQLY
Position: 207-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a207
Chemical type: Peptide from protein
Sequence: FTSDYYQLY
Position: 207-215
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a72
Chemical type: Peptide from protein
Sequence: ALSKGVHFV
Position: 72-80
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a72
Chemical type: Peptide from protein
Sequence: ALSKGVHFV
Position: 72-80
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a139
Chemical type: Peptide from protein
Sequence: LLYDANYFL
Position: 139-147
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF3a139
Chemical type: Peptide from protein
Sequence: LLYDANYFL
Position: 139-147
Source molecule (GenBank): P0DTC3.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N105
Chemical type: Peptide from protein
Sequence: SPRWYFYYL
Position: 105-113
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N105
Chemical type: Peptide from protein
Sequence: SPRWYFYYL
Position: 105-113
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive-High
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N361
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N361
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N361
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N361
Chemical type: Peptide from protein
Sequence: KTFPPTEPK
Position: 361-369
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 M171
Chemical type: Peptide from protein
Sequence: ATSRTLSYYK
Position: 171-180
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 M171
Chemical type: Peptide from protein
Sequence: ATSRTLSYYK
Position: 171-180
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N134
Chemical type: Peptide from protein
Sequence: ATEGALNTPK
Position: 134-143
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N134
Chemical type: Peptide from protein
Sequence: ATEGALNTPK
Position: 134-143
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab5721
Chemical type: Peptide from protein
Sequence: VYIGDPAQL
Position: 5721-5729
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab5721
Chemical type: Peptide from protein
Sequence: VYIGDPAQL
Position: 5721-5729
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N257
Chemical type: Peptide from protein
Sequence: KPRQKRTAT
Position: 257-265
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N257
Chemical type: Peptide from protein
Sequence: KPRQKRTAT
Position: 257-265
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab2949
Chemical type: Peptide from protein
Sequence: RPDTRYVL
Position: 2949-2956
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab2949
Chemical type: Peptide from protein
Sequence: RPDTRYVL
Position: 2949-2956
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAF
Position: 305-314
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N305
Chemical type: Peptide from protein
Sequence: AQFAPSASAF
Position: 305-314
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N9
Chemical type: Peptide from protein
Sequence: QRNAPRITF
Position: 9-17
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N9
Chemical type: Peptide from protein
Sequence: QRNAPRITF
Position: 9-17
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N325
Chemical type: Peptide from protein
Sequence: TPSGTWLTY
Position: 325-333
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N352
Chemical type: Peptide from protein
Sequence: LLNKHIDAY
Position: 352-360
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N352
Chemical type: Peptide from protein
Sequence: LLNKHIDAY
Position: 352-360
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Negative
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N322
Chemical type: Peptide from protein
Sequence: MEVTPSGTWL
Position: 322-331
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 N322
Chemical type: Peptide from protein
Sequence: MEVTPSGTWL
Position: 322-331
Source molecule (GenBank): P0DTC9-1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab6219
Chemical type: Peptide from protein
Sequence: IEYPIIGDEL
Position: 6219-6228
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: SARS-CoV-2 ORF1ab6219
Chemical type: Peptide from protein
Sequence: IEYPIIGDEL
Position: 6219-6228
Source molecule (GenBank): P0DTD1.1
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Direct Ex Vivo