Reference: Yuu Okura; Yuri Ikawa-Teranishi; Akihiko Mizoroki; Noriyuki Takahashi; Takashi Tsushima; Machiko Irie; Zulkarnain Harfuddin; Momoko Miura-Okuda; Shunsuke Ito; Genki Nakamura; Hiroaki Takesue; Yui Ozono; Masamichi Nishihara; Kenta Yamada; Siok Wan Gan; Akira Hayasaka; Shinya Ishii; Tetsuya Wakabayashi; Masaru Muraoka; Nishiki Nagaya; Hiroshi Hino; Takayuki Nemoto; Taichi Kuramochi; Takuya Torizawa; Hideaki Shimada; Takehisa Kitazawa; Makoto Okazaki; Junichi Nezu; Ludvig M Sollid; Tomoyuki Igawa. "Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease." Nature communications (2023).

Epitope: HLA-DQ2.5-alpha1a gliadin peptide
Chemical type: Peptide from protein
Sequence: PFPQPQLPY
Position: 61-69
Source molecule (GenBank): Q9M4L6.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.818
Host:  12-16 weeks

Epitope: HLA-DQ2.5-alpha2 gliadin peptide
Chemical type: Peptide from protein
Sequence: PQPQLPYPQ
Position: 63-71
Source molecule (GenBank): Q9M4L6.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.105
Host:  12-16 weeks

Epitope: HLA-DQ2.5-gamma2 gliadin peptide
Chemical type: Peptide from protein
Sequence: IQPQQPAQL
Position: 279-287
Source molecule (GenBank): M9TGF7.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.769
Host:  12-16 weeks

Epitope: HLA-DQ2.5-hordein 3a peptide
Chemical type: Peptide from protein
Sequence: PIPQQPQPY
Position: 34-42
Source molecule (GenBank): P06471.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.236
Host:  12-16 weeks

Epitope: Epitope of DQN0344AE02 on HLA-DQ2.5 in complex with glia-α1a peptide
Chemical type: Region on multi-chain protein
Discontinuous residues: C: D80, Q82, F83, T86, A89, V90; D: Y92, Q96, D98, I99, R102, K103, A106, R109, V110
Source molecule (GenBank): P01909.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.818
Host:  12-16 weeks

Epitope: Epitope of DQN0344AE02 on HLA-DQ2.5 in complex with glia-α2 peptide
Chemical type: Region on multi-chain protein
Discontinuous residues: C: K65, R78, D80, Q82, F83, L85, T86, A89, V90, K92; D: Y92, Q96, D98, I99, R102, K103, A106, R109
Source molecule (GenBank): P01909.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.105
Host:  12-16 weeks

Epitope: Epitope of DQN0385AE01 on HLA-DQ2.5 in complex with glia-gamma2 peptide
Chemical type: Region on multi-chain protein
Discontinuous residues: C: Y39, P44, L62, G63, K65, R78, D80, Q82, F83, L85, T86, N87, I88, A89, V90, K92, H93; D: Y92, D98, R109
Source molecule (GenBank): P01909.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.769
Host:  12-16 weeks

Epitope: 33mer gliadin
Chemical type: Peptide from protein
Sequence: LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF
Position: 57-89
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Engineered

Epitope: 33mer gliadin
Chemical type: Peptide from protein
Sequence: LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF
Position: 57-89
Source molecule (GenBank): Q9M4L6.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: γ1 gliadin
Chemical type: Peptide from protein
Sequence: PQQPQQSFPQQQQPA
Position: 145-159
Source molecule (GenBank): AAA34272.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: γ3 gliadin
Chemical type: Peptide from protein
Sequence: QQPFPQQPQQPYPQQPQQPFPQP
Position: 81-103
Source molecule (GenBank): ACJ03454.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: γ4a gliadin
Chemical type: Peptide from protein
Sequence: FSQPQQQFPQPQ
Position: 102-113
Source molecule (GenBank): Q8L6B3
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: γ4d gliadin
Chemical type: Peptide from protein
Sequence: WPQQQPFPQPQQPFCQQPQR
Position: 31-50
Source molecule (GenBank): ACJ03453.1
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered

Epitope: B/C hordein
Chemical type: Peptide from protein
Sequence: QPQQPIPQQPQPYPQQ
Assay category: TCell
Result: Positive
Cell type: Jurkat cell (T cell)
Tissue: blood
Culture conditions: Engineered