Reference: David Scharnetzki; Franciska Stappers; Malte Lenders; Eva Brand. "Detailed epitope mapping of neutralizing anti-drug antibodies against recombinant α-galactosidase A in patients with Fabry disease." Molecular genetics and metabolism (2020).

Epitope: AGAL peptide 1
Chemical type: Peptide from protein
Sequence: MQLRNPELHLGCALALRFLA
Position: 1-20
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 1
Chemical type: Peptide from protein
Sequence: MQLRNPELHLGCALALRFLA
Position: 1-20
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 2
Chemical type: Peptide from protein
Sequence: LRFLALVSWDIPGARALDNG
Position: 16-35
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 3
Chemical type: Peptide from protein
Sequence: ALDNGLARTPTMGWLHWERF
Position: 31-50
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 4
Chemical type: Peptide from protein
Sequence: HWERFMCNLDCQEEPDSCIS
Position: 46-65
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 5
Chemical type: Peptide from protein
Sequence: DSCISEKLFMEMAELMVSEG
Position: 61-80
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 6
Chemical type: Peptide from protein
Sequence: MVSEGWKDAGYEYLCIDDCW
Position: 76-95
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 7
Chemical type: Peptide from protein
Sequence: IDDCWMAPQRDSEGRLQADP
Position: 91-110
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Negative
Host: M

Epitope: AGAL peptide 8
Chemical type: Peptide from protein
Sequence: LQADPQRFPHGIRQLANYVH
Position: 106-125
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 10
Chemical type: Peptide from protein
Sequence: DVGNKTCAGFPGSFGYYDID
Position: 136-155
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 11
Chemical type: Peptide from protein
Sequence: YYDIDAQTFADWGVDLLKFD
Position: 151-170
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Negative
Host: M

Epitope: AGAL peptide 12
Chemical type: Peptide from protein
Sequence: LLKFDGCYCDSLENLADGYK
Position: 166-185
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 13
Chemical type: Peptide from protein
Sequence: ADGYKHMSLALNRTGRSIVY
Position: 181-200
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 14
Chemical type: Peptide from protein
Sequence: RSIVYSCEWPLYMWPFQKPN
Position: 196-215
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 14
Chemical type: Peptide from protein
Sequence: RSIVYSCEWPLYMWPFQKPN
Position: 196-215
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 15
Chemical type: Peptide from protein
Sequence: FQKPNYTEIRQYCNHWRNFA
Position: 211-230
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 15
Chemical type: Peptide from protein
Sequence: FQKPNYTEIRQYCNHWRNFA
Position: 211-230
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 16
Chemical type: Peptide from protein
Sequence: WRNFADIDDSWKSIKSILDW
Position: 226-245
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 17
Chemical type: Peptide from protein
Sequence: SILDWTSFNQERIVDVAGPG
Position: 241-260
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 18
Chemical type: Peptide from protein
Sequence: VAGPGGWNDPDMLVIGNFGL
Position: 256-275
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Negative
Host: M

Epitope: AGAL peptide 19
Chemical type: Peptide from protein
Sequence: GNFGLSWNQQVTQMALWAIM
Position: 271-290
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 20
Chemical type: Peptide from protein
Sequence: LWAIMAAPLFMSNDLRHISP
Position: 286-305
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 21
Chemical type: Peptide from protein
Sequence: RHISPQAKALLQDKDVIAIN
Position: 301-320
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 21
Chemical type: Peptide from protein
Sequence: RHISPQAKALLQDKDVIAIN
Position: 301-320
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 22
Chemical type: Peptide from protein
Sequence: VIAINQDPLGKQGYQLRQGD
Position: 316-335
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 23
Chemical type: Peptide from protein
Sequence: LRQGDNFEVWERPLSGLAWA
Position: 331-350
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Negative
Host: M

Epitope: AGAL peptide 24
Chemical type: Peptide from protein
Sequence: GLAWAVAMINRQEIGGPRSY
Position: 346-365
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 25
Chemical type: Peptide from protein
Sequence: GPRSYTIAVASLGKGVACNP
Position: 361-380
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 26
Chemical type: Peptide from protein
Sequence: VACNPACFITQLLPVKRKLG
Position: 376-395
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 26
Chemical type: Peptide from protein
Sequence: VACNPACFITQLLPVKRKLG
Position: 376-395
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 28
Chemical type: Peptide from protein
Sequence: HINPTGTVLLQLENTMQMSL
Position: 406-425
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M

Epitope: AGAL peptide 28
Chemical type: Peptide from protein
Sequence: HINPTGTVLLQLENTMQMSL
Position: 406-425
Source molecule (GenBank): NP_000160.1
Assay category: BCell
Result: Positive
Host: M