Reference: Anish Suri; Ilan Vidavsky; Koen van der Drift; Osami Kanagawa; Michael L Gross; Emil R Unanue. "In APCs, the autologous peptides selected by the diabetogenic I-Ag7 molecule are unique and determined by the amino acid changes in the P9 pocket." Journal of immunology (Baltimore, Md. : 1950) (2002).

Epitope: BSA 304-319
Chemical type: Peptide from protein
Sequence: KPLLEKSHCIAEVEKD
Position: 304-319
Source molecule (GenBank): P02769.4
Assay category: MhcLigandElution
Result: Positive

Epitope: BSA 304-319
Chemical type: Peptide from protein
Sequence: KPLLEKSHCIAEVEKD
Position: 304-319
Source molecule (GenBank): P02769.4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 900.0

Epitope: BSA 304-319
Chemical type: Peptide from protein
Sequence: KPLLEKSHCIAEVEKD
Position: 304-319
Source molecule (GenBank): P02769.4
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 6600.0

Epitope: FK 506 (51-65)
Chemical type: Peptide from protein
Sequence: LGKQEVIRGWEEGVA
Position: 51-65
Source molecule (GenBank): NP_032045.1
Assay category: MhcLigandElution
Result: Positive

Epitope: FK 506 (51-65)
Chemical type: Peptide from protein
Sequence: LGKQEVIRGWEEGVA
Position: 51-65
Source molecule (GenBank): NP_032045.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 600.0

Epitope: FK 506 (51-65)
Chemical type: Peptide from protein
Sequence: LGKQEVIRGWEEGVA
Position: 51-65
Source molecule (GenBank): NP_032045.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2500.0

Epitope: Lysosomal-associated transmembrane protein 5 (213-227)
Chemical type: Peptide from protein
Sequence: KFLKHMNSAMEDSSS
Position: 213-227
Source molecule (GenBank): Q61168.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Lysosomal-associated transmembrane protein 5 (213-227)
Chemical type: Peptide from protein
Sequence: KFLKHMNSAMEDSSS
Position: 213-227
Source molecule (GenBank): Q61168.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1000.0

Epitope: Lysosomal-associated transmembrane protein 5 (213-227)
Chemical type: Peptide from protein
Sequence: KFLKHMNSAMEDSSS
Position: 213-227
Source molecule (GenBank): Q61168.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 4300.0

Epitope: E2B 198-213
Chemical type: Peptide from protein
Sequence: LIHEHMVITDRIENVD
Position: 198-213
Source molecule (GenBank): EDL35858.1
Assay category: MhcLigandElution
Result: Positive

Epitope: E2B 198-213
Chemical type: Peptide from protein
Sequence: LIHEHMVITDRIENVD
Position: 198-213
Source molecule (GenBank): EDL35858.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3000.0

Epitope: E2B 198-213
Chemical type: Peptide from protein
Sequence: LIHEHMVITDRIENVD
Position: 198-213
Source molecule (GenBank): EDL35858.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3300.0

Epitope: E2B 112-126
Chemical type: Peptide from protein
Sequence: YQTIEENIKIFEEDA
Position: 112-126
Source molecule (GenBank): EDL35858.1
Assay category: MhcLigandElution
Result: Positive

Epitope: E2B 112-126
Chemical type: Peptide from protein
Sequence: YQTIEENIKIFEEDA
Position: 112-126
Source molecule (GenBank): EDL35858.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 400.0

Epitope: E2B 112-126
Chemical type: Peptide from protein
Sequence: YQTIEENIKIFEEDA
Position: 112-126
Source molecule (GenBank): EDL35858.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2600.0

Epitope: cyclophilin C-associated protein (325-341)
Chemical type: Peptide from protein
Sequence: VDQWSTETIASHEDIER
Position: 325-341
Source molecule (GenBank): AAA37499.1
Assay category: MhcLigandElution
Result: Positive

Epitope: cyclophilin C-associated protein (325-341)
Chemical type: Peptide from protein
Sequence: VDQWSTETIASHEDIER
Position: 325-341
Source molecule (GenBank): AAA37499.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3300.0

Epitope: Cathepsin D precursor (65-79)
Chemical type: Peptide from protein
Sequence: EPVSELLKNYLDAQY
Position: 65-79
Source molecule (GenBank): P18242.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Cathepsin D precursor (65-79)
Chemical type: Peptide from protein
Sequence: EPVSELLKNYLDAQY
Position: 65-79
Source molecule (GenBank): P18242.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2300.0

Epitope: Procollagen-lysine 5-dioxygenase 161–176
Chemical type: Peptide from protein
Sequence: YAPSLSKLVAEWEGQD
Position: 161-176
Source molecule (GenBank): NP_035252.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Procollagen-lysine 5-dioxygenase 161–176
Chemical type: Peptide from protein
Sequence: YAPSLSKLVAEWEGQD
Position: 161-176
Source molecule (GenBank): NP_035252.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 500.0

Epitope: TCP1 75-91
Chemical type: Peptide from protein
Sequence: YTDLQQILESEKDLEEA
Position: 75-91
Source molecule (GenBank): NP_033347.1
Assay category: MhcLigandElution
Result: Positive

Epitope: TCP1 75-91
Chemical type: Peptide from protein
Sequence: YTDLQQILESEKDLEEA
Position: 75-91
Source molecule (GenBank): NP_033347.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3300.0

Epitope: B-cell differentiation Ag LYB-2  261-275
Chemical type: Peptide from protein
Sequence: TSLSSKLAAFDEPSK
Position: 261-275
Source molecule (GenBank): XP_978244.1
Assay category: MhcLigandElution
Result: Positive

Epitope: B-cell differentiation Ag LYB-2  261-275
Chemical type: Peptide from protein
Sequence: TSLSSKLAAFDEPSK
Position: 261-275
Source molecule (GenBank): XP_978244.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1300.0

Epitope: Bovine apolipoprotein A-I precursor 194–209
Chemical type: Peptide from protein
Sequence: RQRLTARLEALKEGGG
Position: 194-209
Source molecule (GenBank): AAA30381.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Bovine apolipoprotein A-I precursor 194–209
Chemical type: Peptide from protein
Sequence: RQRLTARLEALKEGGG
Position: 194-209
Source molecule (GenBank): AAA30381.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1000.0

Epitope: HSP-60  164-183
Chemical type: Peptide from protein
Sequence: TPEEIAQVATISANGDKDIG
Position: 164-183
Source molecule (GenBank): NP_034607.3
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60  164-183
Chemical type: Peptide from protein
Sequence: TPEEIAQVATISANGDKDIG
Position: 164-183
Source molecule (GenBank): NP_034607.3
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1300.0

Epitope: Apolipoprotein B  617–631
Chemical type: Peptide from protein
Sequence: FAEQYSIQDWAKNLK
Position: 617-631
Source molecule (GenBank): AAA74655.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Apolipoprotein B  617–631
Chemical type: Peptide from protein
Sequence: FAEQYSIQDWAKNLK
Position: 617-631
Source molecule (GenBank): AAA74655.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 23100.0

Epitope: E2B 145-159
Chemical type: Peptide from protein
Sequence: IVHDFNKKLTAYLDL
Position: 145-159
Source molecule (GenBank): Q9Y287.1
Assay category: MhcLigandElution
Result: Positive

Epitope: protein CREG1 precursor (107-122)
Chemical type: Peptide from protein
Sequence: LSPLQQAVSDLQENPE
Position: 107-122
Source molecule (GenBank): NP_035934.1
Assay category: MhcLigandElution
Result: Positive

Epitope: DNA polymerase catalytic chain 264–281
Chemical type: Peptide from protein
Sequence: LELPAGKYVRRAEKKATL
Position: 264-281
Source molecule (GenBank): EDL22730.1
Assay category: MhcLigandElution
Result: Positive

Epitope: transferrin receptor protein 1 (32-48)
Chemical type: Peptide from protein
Sequence: DNSHVEMKLAADEEENA
Position: 32-48
Source molecule (GenBank): NP_035768.1
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60  513-530
Chemical type: Peptide from protein
Sequence: MVEKGIIDPTKVVRTALL
Position: 513-530
Source molecule (GenBank): NP_034607.3
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60  513-530
Chemical type: Peptide from protein
Sequence: MVEKGIIDPTKVVRTALL
Position: 513-530
Source molecule (GenBank): NP_034607.3
Assay category: MhcBinding
Result: Negative

Epitope: MHC class II beta chain A-beta-5 (244-263)
Chemical type: Peptide from protein
Sequence: FIRHRSQKGPRGPPPAGLLQ
Position: 244-263
Source molecule (GenBank): AAG42226.1
Assay category: MhcLigandElution
Result: Positive

Epitope: MHC class II beta chain A-beta-5 (244-263)
Chemical type: Peptide from protein
Sequence: FIRHRSQKGPRGPPPAGLLQ
Position: 244-263
Source molecule (GenBank): AAG42226.1
Assay category: MhcLigandElution
Result: Positive

Epitope: MHC class II beta chain A-beta-5 (244-263)
Chemical type: Peptide from protein
Sequence: FIRHRSQKGPRGPPPAGLLQ
Position: 244-263
Source molecule (GenBank): AAG42226.1
Assay category: MhcBinding
Result: Negative

Epitope: MHC class II beta chain A-beta-5 (244-263)
Chemical type: Peptide from protein
Sequence: FIRHRSQKGPRGPPPAGLLQ
Position: 244-263
Source molecule (GenBank): AAG42226.1
Assay category: MhcBinding
Result: Negative

Epitope: asparagine synthase (131-144)
Chemical type: Peptide from protein
Sequence: LQRLRGMFAFALWD
Position: 131-144
Source molecule (GenBank): WP_019256905.1
Assay category: MhcLigandElution
Result: Positive

Epitope: asparagine synthase (131-144)
Chemical type: Peptide from protein
Sequence: LQRLRGMFAFALWD
Position: 131-144
Source molecule (GenBank): WP_019256905.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 6600.0

Epitope: asparagine synthase (131-144)
Chemical type: Peptide from protein
Sequence: LQRLRGMFAFALWD
Position: 131-144
Source molecule (GenBank): WP_019256905.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 6600.0

Epitope: Beta-2-microglobulin precursor (21-36)
Chemical type: Peptide from protein
Sequence: IQKTPQIQVYSRHPPE
Position: 21-36
Source molecule (GenBank): P01887.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Beta-2-microglobulin precursor (21-36)
Chemical type: Peptide from protein
Sequence: IQKTPQIQVYSRHPPE
Position: 21-36
Source molecule (GenBank): P01887.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 10000.0

Epitope: Beta-2-microglobulin precursor (21-36)
Chemical type: Peptide from protein
Sequence: IQKTPQIQVYSRHPPE
Position: 21-36
Source molecule (GenBank): P01887.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 49500.0

Epitope: B cell receptor CD22 433–448
Chemical type: Peptide from protein
Sequence: APKAVTTVIQSFTPIL
Position: 34-49
Source molecule (GenBank): EDL23979.1
Assay category: MhcLigandElution
Result: Positive

Epitope: B cell receptor CD22 433–448
Chemical type: Peptide from protein
Sequence: APKAVTTVIQSFTPIL
Position: 34-49
Source molecule (GenBank): EDL23979.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 100.0

Epitope: Serotransferrin precursor (268-284)
Chemical type: Peptide from protein
Sequence: MVPSHAVVARTVGGKED
Position: 268-284
Source molecule (GenBank): Q29443.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Serotransferrin precursor (268-284)
Chemical type: Peptide from protein
Sequence: MVPSHAVVARTVGGKED
Position: 268-284
Source molecule (GenBank): Q29443.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 6600.0

Epitope: Serotransferrin precursor (268-284)
Chemical type: Peptide from protein
Sequence: MVPSHAVVARTVGGKED
Position: 268-284
Source molecule (GenBank): Q29443.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 10000.0

Epitope: H2-M beta chain (42-59)
Chemical type: Peptide from protein
Sequence: KIVPCEFGVLSRLAEIIS
Position: 42-59
Source molecule (GenBank): AAA86492.1
Assay category: MhcLigandElution
Result: Positive

Epitope: H2-M beta chain (42-59)
Chemical type: Peptide from protein
Sequence: KIVPCEFGVLSRLAEIIS
Position: 42-59
Source molecule (GenBank): AAA86492.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2000.0

Epitope: TNFR 23-37
Chemical type: Peptide from protein
Sequence: VPAQVVLTPYKPEPG
Position: 23-37
Source molecule (GenBank): NP_035740.2
Assay category: MhcLigandElution
Result: Positive

Epitope: TNFR 23-37
Chemical type: Peptide from protein
Sequence: VPAQVVLTPYKPEPG
Position: 23-37
Source molecule (GenBank): NP_035740.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 300.0

Epitope: Lysosomal alpha-mannosidase 199-214
Chemical type: Peptide from protein
Sequence: HSREQASLFAQMGFDG
Position: 200-215
Source molecule (GenBank): O09159.4
Assay category: MhcLigandElution
Result: Positive

Epitope: phospholipase D3 (456-471)
Chemical type: Peptide from protein
Sequence: SQLEAVFLRDWESPYS
Position: 456-471
Source molecule (GenBank): NP_035246.1
Assay category: MhcLigandElution
Result: Positive

Epitope: lymphotoxin-beta (151-167)
Chemical type: Peptide from protein
Sequence: PELPAAHLIGAWMSGQG
Position: 151-167
Source molecule (GenBank): NP_032544.1
Assay category: MhcLigandElution
Result: Positive

Epitope: I-Ad alpha chain precursor 59–80
Chemical type: Peptide from protein
Sequence: FYVDLDKKKTVWRLPEFGQLIL
Position: 59-80
Source molecule (GenBank): P04228.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Nucleobindin-1 precursor 343–362
Chemical type: Peptide from protein
Sequence: EEELKRFEEELAAREAELNA
Position: 343-362
Source molecule (GenBank): NP_032775.1
Assay category: MhcLigandElution
Result: Positive

Epitope: zinc finger protein ZAS3 (963-977)
Chemical type: Peptide from protein
Sequence: HHPHAREMRRSASEQ
Position: 963-977
Source molecule (GenBank): AAR88090.1
Assay category: MhcLigandElution
Result: Positive

Epitope: TRAF-interacting protein (384-398)
Chemical type: Peptide from protein
Sequence: GAFPLFIRNAVLGQK
Position: 384-398
Source molecule (GenBank): AAH17374.1
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60 (27-46)
Chemical type: Peptide from protein
Sequence: AKDVKFGADARALMLQGVDL
Position: 27-46
Source molecule (GenBank): NP_034607.3
Assay category: MhcLigandElution
Result: Positive

Epitope: alpha-2-HS-glycoprotein (157-171)
Chemical type: Peptide from protein
Sequence: DSRVVHAVEVALATF
Position: 157-171
Source molecule (GenBank): AAI47949.1
Assay category: MhcLigandElution
Result: Positive

Epitope: immunoglobulin heavy chain (30-54)
Chemical type: Peptide from protein
Sequence: YMYWVRQTPEKRLEWVATISGGGSY
Position: 30-54
Source molecule (GenBank): AAA02754.1
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60 (513-529)
Chemical type: Peptide from protein
Sequence: MVEKGIIDPTKVVRTAL
Position: 513-529
Source molecule (GenBank): NP_034607.3
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60 (513-529)
Chemical type: Peptide from protein
Sequence: MVEKGIIDPTKVVRTAL
Position: 513-529
Source molecule (GenBank): NP_034607.3
Assay category: MhcBinding
Result: Negative

Epitope: Ig kappa L chain 174–188
Chemical type: Peptide from protein
Sequence: ERQNGVLNSWTDQDS
Position: 45-59
Source molecule (GenBank): AAF04610.1
Assay category: MhcLigandElution
Result: Positive

Epitope: Ig kappa L chain 174–188
Chemical type: Peptide from protein
Sequence: ERQNGVLNSWTDQDS
Position: 45-59
Source molecule (GenBank): AAF04610.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2200.0

Epitope: Fc RII/CD23 215–230
Chemical type: Peptide from protein
Sequence: DLQGRLVSIHSQKEQD
Position: 176-191
Source molecule (GenBank): AAB28792.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Fc RII/CD23 215–230
Chemical type: Peptide from protein
Sequence: DLQGRLVSIHSQKEQD
Position: 176-191
Source molecule (GenBank): AAB28792.2
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 3100.0

Epitope: activated leukocyte cell adhesion molecule (225-238)
Chemical type: Peptide from protein
Sequence: YGPSGQKTIYSEQE
Position: 225-238
Source molecule (GenBank): NP_033785.1
Assay category: MhcLigandElution
Result: Positive

Epitope: activated leukocyte cell adhesion molecule (225-238)
Chemical type: Peptide from protein
Sequence: YGPSGQKTIYSEQE
Position: 225-238
Source molecule (GenBank): NP_033785.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 6200.0

Epitope: IL-2Rbeta (CD 122) 157–170
Chemical type: Peptide from protein
Sequence: QVSHYIEPYLEFEA
Position: 157-170
Source molecule (GenBank): P16297.1
Assay category: MhcLigandElution
Result: Positive

Epitope: IL-2Rbeta (CD 122) 157–170
Chemical type: Peptide from protein
Sequence: QVSHYIEPYLEFEA
Position: 157-170
Source molecule (GenBank): P16297.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 200.0

Epitope: TGFbeta receptor type II 296–311
Chemical type: Peptide from protein
Sequence: FETVAVKIFPYEEYSS
Position: 271-286
Source molecule (GenBank): NP_083851.3
Assay category: MhcLigandElution
Result: Positive

Epitope: TGFbeta receptor type II 296–311
Chemical type: Peptide from protein
Sequence: FETVAVKIFPYEEYSS
Position: 271-286
Source molecule (GenBank): NP_083851.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 400.0

Epitope: Apolipoprotein A-II (31-46)
Chemical type: Peptide from protein
Sequence: GSELQTQAKAYFEKTQ
Position: 54-69
Source molecule (GenBank): P81644.2
Assay category: MhcLigandElution
Result: Positive

Epitope: Apolipoprotein A-II (31-46)
Chemical type: Peptide from protein
Sequence: GSELQTQAKAYFEKTQ
Position: 54-69
Source molecule (GenBank): P81644.2
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 1800.0

Epitope: alpha-macroglobulin precursor (898-911)
Chemical type: Peptide from protein
Sequence: KDTIIKPLLVEPEG
Position: 898-911
Source molecule (GenBank): NP_001166523.1
Assay category: MhcLigandElution
Result: Positive

Epitope: alpha-macroglobulin precursor (898-911)
Chemical type: Peptide from protein
Sequence: KDTIIKPLLVEPEG
Position: 898-911
Source molecule (GenBank): NP_001166523.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 600.0

Epitope: M17 protein 78-92
Chemical type: Peptide from protein
Sequence: RPSVNPAEGFYENIS
Position: 78-92
Source molecule (GenBank): NP_032125.3
Assay category: MhcLigandElution
Result: Positive

Epitope: clusterin preproprotein (43-58)
Chemical type: Peptide from protein
Sequence: ALKEVKQIKTQIEQTN
Position: 43-58
Source molecule (GenBank): NP_776327.1
Assay category: MhcLigandElution
Result: Positive

Epitope: RAB14, member RAS oncogene family (122-135)
Chemical type: Peptide from protein
Sequence: IGNKADLEAQRDVT
Position: 122-135
Source molecule (GenBank): AAH06081.1
Assay category: MhcLigandElution
Result: Positive

Epitope: HSP-60 (166-181)
Chemical type: Peptide from protein
Sequence: EEIAQVATISANGDKD
Position: 166-181
Source molecule (GenBank): NP_034607.3
Assay category: MhcLigandElution
Result: Positive

Epitope: E2B 113-126
Chemical type: Peptide from protein
Sequence: QTIEENIKIFEEDA
Position: 113-126
Source molecule (GenBank): EDL35858.1
Assay category: MhcLigandElution
Result: Positive