Reference: Kelly Ann Mahool; Emily Nguyen; Victoria Godfrey; Ann Marie Stanley; Tyler Brady; Adam Gamson; Kim Rosenthal; Justin Green; Ondrej Podlaha; Bret R Sellman; Christine Tkaczyk; Vancheswaran Gopalakrishnan. "Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary Clostridioides difficile Isolates." The Journal of infectious diseases (2025).

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000341
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.66
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Quantitative measurement: 519000.0
Host: F

Epitope: Epitope of mAb AZD5148
Chemical type: Discontinuous protein residues
Discontinuous residues: K322, Y323, K324, E325, E340, E341, Q343, S344, E347, S348, L350, A351, S354
Source molecule (GenBank): CBE02479.1
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 5410000.0
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00493
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Quantitative measurement: 0.91
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F

Epitope: Epitope of Bezlotoxumab
Chemical type: Discontinuous protein residues
Discontinuous residues: E1878, Y1887, Q1890, S1900, T1901, E1902, D1903, F1905, D1939, N1941, R1943, G1944, V1946, E1947, P1960, E1961, Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
Source molecule (GenBank): P18177.3
Assay category: BCell
Result: Positive
Host: F