Reference: Rocky Strollo; Chiara Vinci; Y K Stella Man; Sara Bruzzaniti; Erica Piemonte; Ghadeer Alhamar; Silvia Irina Briganti; Ilaria Malandrucco; Flavia Tramontana; Chiara Fanali; James Garnett; Roberto Buccafusca; Perrin Guyer; Mark Mamula; Eddie A James; Paolo Pozzilli; Johnny Ludvigsson; Paul G Winyard; Mario Galgani; Ahuva Nissim. "Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes." Diabetologia (2023).

Epitope: INSP-1_B:16-25
Chemical type: Peptide from protein
Sequence: YLVCGERGFF
Position: 40-49
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Negative
Host:  mean: 11 years

Epitope: INSP-2_B:11–22
Chemical type: Peptide from protein
Sequence: LVEALYLVCGER
Position: 35-46
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Negative
Host:  mean: 11 years

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Negative
Host:  mean: 11 years

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive
Host:  mean: 11 years

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive-High
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive-High
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-5_B:1–7
Chemical type: Peptide from protein
Sequence: FVNQHLC
Position: 25-31
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Negative
Host:  mean: 11 years

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive
Host:  mean: 18.75 years

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Low
Host:  mean: 29.7 years

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: INSP-6+ R_B:21–31
Chemical type: Peptide from protein
Sequence: ERGFFYTPKTR
Position: 45-55
Source molecule (GenBank): CAA08766.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Positive
Host:  mean: 11 years

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Positive-High
Host:  mean:13.8 years

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: BCell
Result: Positive-High
Host:  mean: 11 years

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-3_A:12–21
Chemical type: Peptide from protein
Sequence: SLYQLENYCN
Position: 85-94
Source molecule (GenBank): AEG19452.1
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive
Host:  mean: 11 years

Epitope: oxPTM-INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: oxPTM-INSP-4_B:11–30
Chemical type: Peptide from protein
Sequence: LVEALYLVCGERGFFYTPKT
Position: 35-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: oxPTM-INSP-6_B:21–30
Chemical type: Peptide from protein
Sequence: ERGFFYTPKT
Position: 45-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive
Host:  mean: 11 years

Epitope: oxPTM-INSP-6_B:21–30
Chemical type: Peptide from protein
Sequence: ERGFFYTPKT
Position: 45-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: oxPTM-INSP-6_B:21–30
Chemical type: Peptide from protein
Sequence: ERGFFYTPKT
Position: 45-54
Source molecule (GenBank): CAA08766.1
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 2
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: BCell
Result: Positive-Intermediate
Host:  mean: 11 years

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: BCell
Result: Positive-Low
Host:  mean:13.8 years

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 29.7 years
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: oxPTM-INSP-6_B:21–30_peptide 3
Chemical type: Peptide, no natural source
Sequence: ERGYYYTPKT
Assay category: TCell
Result: Positive
Host:  mean: 18.75 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated