Reference: P Sarobe; J-J Lasarte; N García; M P Civeira; F Borrás-Cuesta; J Prieto. "Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins." Journal of viral hepatitis (2006).

Epitope: E2.384
Chemical type: Peptide from protein
Sequence: EPYTTGGTHGRAAHG
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.389
Chemical type: Peptide from protein
Sequence: GGTHGRAAHGLTSLF
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.394
Chemical type: Peptide from protein
Sequence: RAAHGLTSLFTPGPA
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.399
Chemical type: Peptide from protein
Sequence: LTSLFTPGPAQKIQL
Position: 164-178
Source molecule (GenBank): AAM55246.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.404
Chemical type: Peptide from protein
Sequence: TPGPAQKIQLVNTNG
Position: 213-227
Source molecule (GenBank): BAD06568.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.409
Chemical type: Peptide from protein
Sequence: QKIQLVNTNGSWHIN
Position: 409-423
Source molecule (GenBank): BAA00452.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.414
Chemical type: Peptide from protein
Sequence: VNTNGSWHINRTALN
Position: 414-428
Source molecule (GenBank): BAA00706.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.419
Chemical type: Peptide from protein
Sequence: SWHINRTALNCNDSL
Position: 419-433
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.424
Chemical type: Peptide from protein
Sequence: RTALNCNDSLQTGFL
Position: 424-438
Source molecule (GenBank): BAA00452.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.429
Chemical type: Peptide from protein
Sequence: CNDSLQTGFLAALFY
Position: 429-443
Source molecule (GenBank): P26663.3
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.434
Chemical type: Peptide from protein
Sequence: QTGFLAALFYTHRFN
Position: 434-448
Source molecule (GenBank): BAA09075.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.439
Chemical type: Peptide from protein
Sequence: AALFYTHRFNASGCS
Position: 121-135
Source molecule (GenBank): ABG54931.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.444
Chemical type: Peptide from protein
Sequence: THRFNASGCSERMAS
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.449
Chemical type: Peptide from protein
Sequence: ASGCSERMASCRPID
Position: 122-136
Source molecule (GenBank): AAV87592.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.454
Chemical type: Peptide from protein
Sequence: ERMASCRPIDQFDQG
Position: 454-468
Source molecule (GenBank): AAF65953.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.459
Chemical type: Peptide from protein
Sequence: CRPIDQFDQGWGPIT
Position: 459-473
Source molecule (GenBank): AAF65953.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.464
Chemical type: Peptide from protein
Sequence: QFDQGWGPITYNESH
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.469
Chemical type: Peptide from protein
Sequence: WGPITYNESHGLDQR
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.474
Chemical type: Peptide from protein
Sequence: YNESHGLDQRPYCWH
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.479
Chemical type: Peptide from protein
Sequence: GLDQRPYCWHYAPQP
Position: 18-32
Source molecule (GenBank): CAD57300.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.489
Chemical type: Peptide from protein
Sequence: YAPQPCGIVPALQVC
Position: 489-503
Source molecule (GenBank): Q68948
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.499
Chemical type: Peptide from protein
Sequence: ALQVCGPVYCFTPSP
Position: 499-513
Source molecule (GenBank): Q68948
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.504
Chemical type: Peptide from protein
Sequence: GPVYCFTPSPVVVGT
Position: 504-518
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.509
Chemical type: Peptide from protein
Sequence: FTPSPVVVGTTDRFG
Position: 509-523
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.514
Chemical type: Peptide from protein
Sequence: VVVGTTDRFGAPTYR
Position: 514-528
Source molecule (GenBank): AAD56189.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.519
Chemical type: Peptide from protein
Sequence: TDRFGAPTYRWGENE
Position: 519-533
Source molecule (GenBank): AAD56189.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.524
Chemical type: Peptide from protein
Sequence: APTYRWGENETDVLL
Position: 524-538
Source molecule (GenBank): AAD56189.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.534
Chemical type: Peptide from protein
Sequence: TDVLLLNNTRPPRGN
Position: 534-548
Source molecule (GenBank): AAY82055.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.539
Chemical type: Peptide from protein
Sequence: LNNTRPPRGNWFGCT
Position: 539-553
Source molecule (GenBank): AAY82069.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.544
Chemical type: Peptide from protein
Sequence: PPRGNWFGCTWMNST
Position: 544-558
Source molecule (GenBank): BAD73987.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.549
Chemical type: Peptide from protein
Sequence: WFGCTWMNSTGFTKT
Position: 549-563
Source molecule (GenBank): BAA09073.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.554
Chemical type: Peptide from protein
Sequence: WMNSTGFTKTCGGPP
Position: 554-568
Source molecule (GenBank): BAA09073.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.559
Chemical type: Peptide from protein
Sequence: GFTKTCGGPPCNIGG
Position: 559-573
Source molecule (GenBank): BAA09073.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.564
Chemical type: Peptide from protein
Sequence: CGGPPCNIGGVGNNT
Position: 564-578
Source molecule (GenBank): AAT40682.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.569
Chemical type: Peptide from protein
Sequence: CNIGGVGNNTLICPT
Position: 569-583
Source molecule (GenBank): AAF65964.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.574
Chemical type: Peptide from protein
Sequence: VGNNTLICPTDCFRK
Position: 574-588
Source molecule (GenBank): AAT00643.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.579
Chemical type: Peptide from protein
Sequence: LICPTDCFRKHPEAT
Position: 579-593
Source molecule (GenBank): AAT00643.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.584
Chemical type: Peptide from protein
Sequence: DCFRKHPEATYTKCG
Position: 584-598
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: E2.589
Chemical type: Peptide from protein
Sequence: HPEATYTKCGSGPWL
Position: 589-603
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1658
Chemical type: Peptide from protein
Sequence: STWVLVGGVLAALAA
Position: 1658-1672
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1663
Chemical type: Peptide from protein
Sequence: VGGVLAALAAYCLTT
Position: 1663-1677
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1668
Chemical type: Peptide from protein
Sequence: AALAAYCLTTGCVVI
Position: 563-577
Source molecule (GenBank): AAT94263.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1673
Chemical type: Peptide from protein
Sequence: YCLTTGCVVIVGRII
Position: 568-582
Source molecule (GenBank): AAT94263.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1678
Chemical type: Peptide from protein
Sequence: GCVVIVGRIILSGRP
Position: 1678-1692
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1683
Chemical type: Peptide from protein
Sequence: VGRIILSGRPAIVPD
Position: 1683-1697
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1688
Chemical type: Peptide from protein
Sequence: LSGRPAIVPDREVLY
Position: 1688-1702
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1698
Chemical type: Peptide from protein
Sequence: REVLYQEFDEMEECA
Position: 1698-1712
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1703
Chemical type: Peptide from protein
Sequence: QEFDEMEECASHLPY
Position: 1703-1717
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1708
Chemical type: Peptide from protein
Sequence: MEECASHLPYIEQGM
Position: 1708-1722
Source molecule (GenBank): BAA25076.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1713
Chemical type: Peptide from protein
Sequence: SHLPYIEQGMQLAEQ
Position: 1713-1727
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1718
Chemical type: Peptide from protein
Sequence: IEQGMQLAEQFKQKA
Position: 1718-1732
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1723
Chemical type: Peptide from protein
Sequence: QLAEQFKQKALGLLQ
Position: 1723-1737
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1728
Chemical type: Peptide from protein
Sequence: FKQKALGLLQTATKQ
Position: 1728-1742
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1733
Chemical type: Peptide from protein
Sequence: LGLLQTATKQAEAAA
Position: 1733-1747
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1738
Chemical type: Peptide from protein
Sequence: TATKQAEAAAPVVES
Position: 1738-1752
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1743
Chemical type: Peptide from protein
Sequence: AEAAAPVVESKWRAL
Position: 1743-1757
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1753
Chemical type: Peptide from protein
Sequence: KWRALETFWAKHMWN
Position: 1753-1767
Source molecule (GenBank): BAA02756.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1758
Chemical type: Peptide from protein
Sequence: ETFWAKHMWNFISGI
Position: 1758-1772
Source molecule (GenBank): BAA02756.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1763
Chemical type: Peptide from protein
Sequence: KHMWNFISGIQYLAG
Position: 1763-1777
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1768
Chemical type: Peptide from protein
Sequence: FISGIQYLAGLSTLP
Position: 1768-1782
Source molecule (GenBank): AAA86907.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1773
Chemical type: Peptide from protein
Sequence: QYLAGLSTLPGNPAI
Position: 1773-1787
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1778
Chemical type: Peptide from protein
Sequence: LSTLPGNPAIASLMA
Position: 1778-1792
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1778
Chemical type: Peptide from protein
Sequence: LSTLPGNPAIASLMA
Position: 1778-1792
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1783
Chemical type: Peptide from protein
Sequence: GNPAIASLMAFTASV
Position: 1783-1797
Source molecule (GenBank): BAA01728.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1788
Chemical type: Peptide from protein
Sequence: ASLMAFTASVTSPLT
Position: 1794-1808
Source molecule (GenBank): AAC03058.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1793
Chemical type: Peptide from protein
Sequence: FTASVTSPLTTQSTL
Position: 1793-1807
Source molecule (GenBank): AAT00643.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1798
Chemical type: Peptide from protein
Sequence: TSPLTTQSTLLLNIL
Position: 192-206
Source molecule (GenBank): AAA79971.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1803
Chemical type: Peptide from protein
Sequence: TQSTLLLNILGGWVA
Position: 197-211
Source molecule (GenBank): AAA79971.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1808
Chemical type: Peptide from protein
Sequence: LLNILGGWVAAQLAP
Position: 1808-1822
Source molecule (GenBank): ABV46294.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1813
Chemical type: Peptide from protein
Sequence: GGWVAAQLAPPSAAS
Position: 1813-1827
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1818
Chemical type: Peptide from protein
Sequence: AQLAPPSAASAFVGA
Position: 1818-1832
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1823
Chemical type: Peptide from protein
Sequence: PSAASAFVGAGIAGA
Position: 1823-1837
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1828
Chemical type: Peptide from protein
Sequence: AFVGAGIAGAAVGSI
Position: 1828-1842
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1833
Chemical type: Peptide from protein
Sequence: GIAGAAVGSIGLGKV
Position: 1833-1847
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1838
Chemical type: Peptide from protein
Sequence: AVGSIGLGKVLVDIL
Position: 1838-1852
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1843
Chemical type: Peptide from protein
Sequence: GLGKVLVDILAGYGA
Position: 1843-1857
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: NS4a.1848
Chemical type: Peptide from protein
Sequence: LVDILAGYGAGVAGA
Position: 1848-1862
Source molecule (GenBank): BAA03375.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo