Reference: Yi Sun; Tyler J Florio; Sagar Gupta; Michael C Young; Quinlen F Marshall; Samuel E Garfinkle; Georgia F Papadaki; Hau V Truong; Emily Mycek; Peiyao Li; Alvin Farrel; Nicole L Church; Shereen Jabar; Matthew D Beasley; Ben R Kiefel; Mark Yarmarkovich; Leena Mallik; John M Maris; Nikolaos G Sgourakis. "Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion." Science immunology (2023).

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 47.4

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Negative

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 47.4

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 44.2

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2.11

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 66.0

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 63.0

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 50.0

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 70.7

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 38.8

Epitope: PHOX2B
Chemical type: Peptide from protein
Sequence: QYNPIRTTF
Position: 43-51
Source molecule (GenBank): Q99453.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 58.9

Epitope: ATG2A
Chemical type: Peptide from protein
Sequence: LYLPVRVLI
Position: 1126-1134
Source molecule (GenBank): Q2TAZ0.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 62.2

Epitope: ATG2A
Chemical type: Peptide from protein
Sequence: LYLPVRVLI
Position: 1126-1134
Source molecule (GenBank): Q2TAZ0.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.8

Epitope: ATG2A
Chemical type: Peptide from protein
Sequence: LYLPVRVLI
Position: 1126-1134
Source molecule (GenBank): Q2TAZ0.3
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3.1

Epitope: Epitope of 10LH scFv on PHOX2B–HLA-A*24:02–β2m complex
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R43, E57, D60, E61, G64, K65, Q71, T72, E75, A149, H150, V151, Q154, A157, Y158, G161, T162, D165, R169; C: Q43, P46, R48, T49, T50
Source molecule (GenBank): AAB40048.1
Assay category: BCell
Result: Positive

Epitope: Epitope of 10LH scFv on PHOX2B–HLA-A*24:02–β2m complex
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R43, E57, D60, E61, G64, K65, Q71, T72, E75, A149, H150, V151, Q154, A157, Y158, G161, T162, D165, R169; C: Q43, P46, R48, T49, T50
Source molecule (GenBank): AAB40048.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.11

Epitope: Epitope of 10LH scFv on PHOX2B–HLA-A*24:02–β2m complex
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R43, E57, D60, E61, G64, K65, Q71, T72, E75, A149, H150, V151, Q154, A157, Y158, G161, T162, D165, R169; C: Q43, P46, R48, T49, T50
Source molecule (GenBank): AAB40048.1
Assay category: BCell
Result: Positive
Quantitative measurement: 11.1

Epitope: Epitope of 10LH scFv on PHOX2B–HLA-A*24:02–β2m complex
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R43, E57, D60, E61, G64, K65, Q71, T72, E75, A149, H150, V151, Q154, A157, Y158, G161, T162, D165, R169; C: Q43, P46, R48, T49, T50
Source molecule (GenBank): AAB40048.1
Assay category: BCell
Result: Positive
Quantitative measurement: 200000.0

Epitope: Epitope of 10LH scFv on PHOX2B–HLA-A*24:02–β2m complex
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R43, E57, D60, E61, G64, K65, Q71, T72, E75, A149, H150, V151, Q154, A157, Y158, G161, T162, D165, R169; C: Q43, P46, R48, T49, T50
Source molecule (GenBank): AAB40048.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0022

Epitope: PHOX2B Q1A
Chemical type: Peptide, no natural source
Sequence: AYNPIRTTF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 66.5

Epitope: PHOX2B R6A
Chemical type: Peptide, no natural source
Sequence: QYNPIATTF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 65.9

Epitope: PHOX2B T7A
Chemical type: Peptide, no natural source
Sequence: QYNPIRATF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 68.5

Epitope: PHOX2B T8A
Chemical type: Peptide, no natural source
Sequence: QYNPIRTAF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 60.7

Epitope: PHOX2B I5L
Chemical type: Peptide, no natural source
Sequence: QYNPLRTTF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 61.5

Epitope: PHOX2B I5V
Chemical type: Peptide, no natural source
Sequence: QYNPVRTTF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 66.6

Epitope: PHOX2B I5G
Chemical type: Peptide, no natural source
Sequence: QYNPGRTTF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 57.1

Epitope: ABCA8
Chemical type: Peptide from protein
Sequence: MWQAIRATF
Position: 1451-1459
Source molecule (GenBank): A0A0A0MSU4.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 58.7

Epitope: GLB1
Chemical type: Peptide from protein
Sequence: KYFALRNII
Position: 346-354
Source molecule (GenBank): P16278.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 59.1

Epitope: 3MRE
Chemical type: Peptide, no natural source
Sequence: GYCTLRAMF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 61.7

Epitope: 6MT3
Chemical type: Peptide, no natural source
Sequence: FYDLIRLSF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 55.0

Epitope: 4QRT
Chemical type: Peptide, no natural source
Sequence: EYNIIRIYF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 62.4

Epitope: 5U98
Chemical type: Peptide, no natural source
Sequence: VYTDIRVKF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 69.7

Epitope: 1E27
Chemical type: Peptide, no natural source
Sequence: LYPVVRGEF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 62.9

Epitope: 1SYS
Chemical type: Peptide, no natural source
Sequence: EYPTVRGKF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 58.3