Reference: Tanja Bauer; Klaus Weinberger; Wolfgang Jilg. "Variants of two major T cell epitopes within the hepatitis B surface antigen are not recognized by specific T helper cells of vaccinated individuals." Hepatology (Baltimore, Md.) (2002).

Epitope: HBsAg 16-33 (p1)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLD
Position: 190-207
Source molecule (GenBank): P03141.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLD
Position: 190-207
Source molecule (GenBank): P03141.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLD
Position: 190-207
Source molecule (GenBank): P03141.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 136-155 (p2)
Chemical type: Peptide from protein
Sequence: SCCCTKPTDGNCTCIPIPSS
Position: 310-329
Source molecule (GenBank): P03141.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 163-174 (p3)
Chemical type: Peptide from protein
Sequence: WEWASVRFSWLS
Position: 337-348
Source molecule (GenBank): P03141.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (p4)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAA45523.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (p4)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAA45523.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (p4)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAA45523.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M2)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPLSLD
Position: 16-33
Source molecule (GenBank): AAF23467.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M2)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPLSLD
Position: 16-33
Source molecule (GenBank): AAF23467.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M2)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPLSLD
Position: 16-33
Source molecule (GenBank): AAF23467.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M3)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPLSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M3)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPLSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M3)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPLSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M4)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILTIPQSLD
Position: 30-47
Source molecule (GenBank): ABI15501.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M4)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILTIPQSLD
Position: 30-47
Source molecule (GenBank): ABI15501.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M4)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILTIPQSLD
Position: 30-47
Source molecule (GenBank): ABI15501.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M5)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILKIPQSLD
Position: 16-33
Source molecule (GenBank): AAW65563.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M5)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILKIPQSLD
Position: 16-33
Source molecule (GenBank): AAW65563.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M5)
Chemical type: Peptide from protein
Sequence: QAVCFLLTKILKIPQSLD
Position: 16-33
Source molecule (GenBank): AAW65563.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M6)
Chemical type: Peptide, no natural source
Sequence: QAVCFLLTKIRTIPQSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M6)
Chemical type: Peptide, no natural source
Sequence: QAVCFLLTKIRTIPQSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M6)
Chemical type: Peptide, no natural source
Sequence: QAVCFLLTKIRTIPQSLD
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M7)
Chemical type: Peptide from protein
Sequence: QAGFFWLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): CAA53363.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M7)
Chemical type: Peptide from protein
Sequence: QAGFFWLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): CAA53363.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M7)
Chemical type: Peptide from protein
Sequence: QAGFFWLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): CAA53363.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M8)
Chemical type: Peptide from protein
Sequence: QAVFFLLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): ABB77829.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M8)
Chemical type: Peptide from protein
Sequence: QAVFFLLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): ABB77829.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M8)
Chemical type: Peptide from protein
Sequence: QAVFFLLTRILTIPQSLD
Position: 16-33
Source molecule (GenBank): ABB77829.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M9)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLH
Position: 16-33
Source molecule (GenBank): AAA62814.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M9)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLH
Position: 16-33
Source molecule (GenBank): AAA62814.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M9)
Chemical type: Peptide from protein
Sequence: QAGFFLLTRILTIPQSLH
Position: 16-33
Source molecule (GenBank): AAA62814.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M10)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPKSLD
Position: 179-196
Source molecule (GenBank): P24025.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M10)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPKSLD
Position: 179-196
Source molecule (GenBank): P24025.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M10)
Chemical type: Peptide from protein
Sequence: QAGFFLLTKILTIPKSLD
Position: 179-196
Source molecule (GenBank): P24025.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M11)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPQSLD
Position: 16-33
Source molecule (GenBank): BAC55954.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M11)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPQSLD
Position: 16-33
Source molecule (GenBank): BAC55954.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 16-33 (p1/M11)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPQSLD
Position: 16-33
Source molecule (GenBank): BAC55954.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M12)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPLSLD
Position: 179-196
Source molecule (GenBank): P17397.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M12)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPLSLD
Position: 179-196
Source molecule (GenBank): P17397.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 16-33 (p1/M12)
Chemical type: Peptide from protein
Sequence: QAGFFSLTKILTIPLSLD
Position: 179-196
Source molecule (GenBank): P17397.3
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M1)
Chemical type: Peptide from protein
Sequence: LPLLPIFYCLWVYI
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M1)
Chemical type: Peptide from protein
Sequence: LPLLPIFYCLWVYI
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M2)
Chemical type: Peptide from protein
Sequence: FPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAC62952.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M2)
Chemical type: Peptide from protein
Sequence: FPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAC62952.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M2)
Chemical type: Peptide from protein
Sequence: FPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): AAC62952.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M4)
Chemical type: Peptide from protein
Sequence: IPLLLIFFCLWVYI
Position: 213-226
Source molecule (GenBank): BAF49398.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M4)
Chemical type: Peptide from protein
Sequence: IPLLLIFFCLWVYI
Position: 213-226
Source molecule (GenBank): BAF49398.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M4)
Chemical type: Peptide from protein
Sequence: IPLLLIFFCLWVYI
Position: 213-226
Source molecule (GenBank): BAF49398.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M5)
Chemical type: Peptide from protein
Sequence: IPLLPIFCCLWVSI
Position: 213-226
Source molecule (GenBank): CAA53348.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M5)
Chemical type: Peptide from protein
Sequence: IPLLPIFCCLWVSI
Position: 213-226
Source molecule (GenBank): CAA53348.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M5)
Chemical type: Peptide from protein
Sequence: IPLLPIFCCLWVSI
Position: 213-226
Source molecule (GenBank): CAA53348.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M6)
Chemical type: Peptide from protein
Sequence: LPLLPIFCCLWAYI
Position: 213-226
Source molecule (GenBank): ABE01571.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M6)
Chemical type: Peptide from protein
Sequence: LPLLPIFCCLWAYI
Position: 213-226
Source molecule (GenBank): ABE01571.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M6)
Chemical type: Peptide from protein
Sequence: LPLLPIFCCLWAYI
Position: 213-226
Source molecule (GenBank): ABE01571.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M7)
Chemical type: Peptide from protein
Sequence: TPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): ABE01765.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M7)
Chemical type: Peptide from protein
Sequence: TPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): ABE01765.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M7)
Chemical type: Peptide from protein
Sequence: TPLLPIFFCLWVYI
Position: 213-226
Source molecule (GenBank): ABE01765.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M8)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWVII
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M8)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWVII
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M8)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWVII
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M9)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): AAA45487.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M9)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): AAA45487.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M9)
Chemical type: Peptide from protein
Sequence: LPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): AAA45487.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M11)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): CAJ55525.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: HBsAg 213-226 (P4/M11)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): CAJ55525.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HBsAg 213-226 (P4/M11)
Chemical type: Peptide from protein
Sequence: IPLLPIFFCLWAYI
Position: 213-226
Source molecule (GenBank): CAJ55525.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo