Reference: Ashley M Curran; Alexander A Girgis; Yura Jang; Jonathan D Crawford; Mekha A Thomas; Ryan Kawalerski; Jeff Coller; Clifton O Bingham; Chan Hyun Na; Erika Darrah. "Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis." Nature communications (2023).

Epitope: Fib_A2
Chemical type: Peptide from protein
Sequence: LQKNVRAQLVDMKRLE
Position: 155-170
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A2
Chemical type: Peptide from protein
Sequence: LQKNVRAQLVDMKRLE
Position: 155-170
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A2
Chemical type: Peptide from protein
Sequence: LQKNVRAQLVDMKRLE
Position: 155-170
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_A2
Chemical type: Peptide from protein
Sequence: LQKNVRAQLVDMKRLE
Position: 155-170
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Fib_B1
Chemical type: Peptide from protein
Sequence: LEKHQLYIDETVNSNIPT
Position: 176-193
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Positive-Low
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B1
Chemical type: Peptide from protein
Sequence: LEKHQLYIDETVNSNIPT
Position: 176-193
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Negative
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B1
Chemical type: Peptide from protein
Sequence: LEKHQLYIDETVNSNIPT
Position: 176-193
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_B1
Chemical type: Peptide from protein
Sequence: LEKHQLYIDETVNSNIPT
Position: 176-193
Source molecule (GenBank): P02675.2
Assay category: MhcBinding
Result: Positive

Epitope: Fib_B4
Chemical type: Peptide from protein
Sequence: NEANKYQISVNKYRG
Position: 363-377
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B4
Chemical type: Peptide from protein
Sequence: NEANKYQISVNKYRG
Position: 363-377
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Negative
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B4
Chemical type: Peptide from protein
Sequence: NEANKYQISVNKYRG
Position: 363-377
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_B4
Chemical type: Peptide from protein
Sequence: NEANKYQISVNKYRG
Position: 363-377
Source molecule (GenBank): P02675.2
Assay category: MhcBinding
Result: Positive

Epitope: Fib_G2
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNGIIW
Position: 375-395
Source molecule (GenBank): P02679.3
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_G2
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNGIIW
Position: 375-395
Source molecule (GenBank): P02679.3
Assay category: TCell
Result: Negative
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_G2
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNGIIW
Position: 375-395
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_G2
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNGIIW
Position: 375-395
Source molecule (GenBank): P02679.3
Assay category: MhcBinding
Result: Positive-Low

Epitope: Fib_A4
Chemical type: Peptide from protein
Sequence: GSAGHWTSESSVSGSTG
Position: 368-384
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A4
Chemical type: Peptide from protein
Sequence: GSAGHWTSESSVSGSTG
Position: 368-384
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A4
Chemical type: Peptide from protein
Sequence: GSAGHWTSESSVSGSTG
Position: 368-384
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_A4
Chemical type: Peptide from protein
Sequence: GSAGHWTSESSVSGSTG
Position: 368-384
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Positive

Epitope: Fib_B3
Chemical type: Peptide from protein
Sequence: TSEMYLIQPDSSVKPY
Position: 251-266
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B3
Chemical type: Peptide from protein
Sequence: TSEMYLIQPDSSVKPY
Position: 251-266
Source molecule (GenBank): P02675.2
Assay category: TCell
Result: Positive-High
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_B3
Chemical type: Peptide from protein
Sequence: TSEMYLIQPDSSVKPY
Position: 251-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_B3
Chemical type: Peptide from protein
Sequence: TSEMYLIQPDSSVKPY
Position: 251-266
Source molecule (GenBank): P02675.2
Assay category: MhcBinding
Result: Positive-Low

Epitope: Fib_G1
Chemical type: Peptide from protein
Sequence: YNPDESSKPNMIDAATLKSRKM
Position: 94-115
Source molecule (GenBank): P02679.3
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_G1
Chemical type: Peptide from protein
Sequence: YNPDESSKPNMIDAATLKSRKM
Position: 94-115
Source molecule (GenBank): P02679.3
Assay category: TCell
Result: Negative
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_G1
Chemical type: Peptide from protein
Sequence: YNPDESSKPNMIDAATLKSRKM
Position: 94-115
Source molecule (GenBank): P02679.3
Assay category: MhcBinding
Result: Positive-High

Epitope: Fib_A1
Chemical type: Peptide from protein
Sequence: DSGEGDFLAEGGVR
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A1
Chemical type: Peptide from protein
Sequence: DSGEGDFLAEGGVR
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A1
Chemical type: Peptide from protein
Sequence: DSGEGDFLAEGGVR
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_A1
Chemical type: Peptide from protein
Sequence: DSGEGDFLAEGGVR
Assay category: MhcBinding
Result: Positive-Low

Epitope: Fib_A5
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSES
Position: 537-551
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A5
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSES
Position: 537-551
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A5
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSES
Position: 537-551
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_A5
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSES
Position: 537-551
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Negative

Epitope: Fib_A6
Chemical type: Peptide from protein
Sequence: YSKQFTSSTSYNRGDS
Position: 579-594
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A6
Chemical type: Peptide from protein
Sequence: YSKQFTSSTSYNRGDS
Position: 579-594
Source molecule (GenBank): P02671.2
Assay category: TCell
Result: Positive
MHC allele types: 52 63 407 408
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Fib_A6
Chemical type: Peptide from protein
Sequence: YSKQFTSSTSYNRGDS
Position: 579-594
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Fib_A6
Chemical type: Peptide from protein
Sequence: YSKQFTSSTSYNRGDS
Position: 579-594
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Positive-High

Epitope: NPGSSERGSAGHWTSESSVSGSTG
Chemical type: Peptide from protein
Sequence: NPGSSERGSAGHWTSESSVSGSTG
Position: 361-384
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SAGHWTSESSVSGSTGQWH
Chemical type: Peptide from protein
Sequence: SAGHWTSESSVSGSTGQWH
Position: 369-387
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SAGHWTSESSVSGSTG
Chemical type: Peptide from protein
Sequence: SAGHWTSESSVSGSTG
Position: 369-384
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: AGHWTSESSVSGSTG
Chemical type: Peptide from protein
Sequence: AGHWTSESSVSGSTG
Position: 370-384
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: AGHWTSESSVSG
Chemical type: Peptide from protein
Sequence: AGHWTSESSVSG
Position: 370-381
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GHWTSESSVSGST
Chemical type: Peptide from protein
Sequence: GHWTSESSVSGST
Position: 371-383
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: LGEFVSETESRGSE
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSE
Position: 537-550
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: LGEFVSETESRG
Chemical type: Peptide from protein
Sequence: LGEFVSETESRG
Position: 537-548
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: LGEFVSETESR
Chemical type: Peptide from protein
Sequence: LGEFVSETESR
Position: 537-547
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: KNVRAQLVDMKR
Chemical type: Peptide from protein
Sequence: KNVRAQLVDMKR
Position: 157-168
Source molecule (GenBank): P02671.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: EKHQLYIDETVNSNIPT
Chemical type: Peptide from protein
Sequence: EKHQLYIDETVNSNIPT
Position: 177-193
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: KGGETSEMYLIQPDSSVKPY
Chemical type: Peptide from protein
Sequence: KGGETSEMYLIQPDSSVKPY
Position: 247-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGETSEMYLIQPDSSVKPY
Chemical type: Peptide from protein
Sequence: GGETSEMYLIQPDSSVKPY
Position: 248-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GETSEMYLIQPDSSVKPY
Chemical type: Peptide from protein
Sequence: GETSEMYLIQPDSSVKPY
Position: 249-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SEMYLIQPDSSVKPY
Chemical type: Peptide from protein
Sequence: SEMYLIQPDSSVKPY
Position: 252-266
Source molecule (GenBank): P02675.2
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: YNPDESSKPNMIDAATLKSRK
Chemical type: Peptide from protein
Sequence: YNPDESSKPNMIDAATLKSRK
Position: 94-114
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: NPDESSKPNMIDAATLKSRKM
Chemical type: Peptide from protein
Sequence: NPDESSKPNMIDAATLKSRKM
Position: 95-115
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: NPDESSKPNMIDAATLKSRK
Chemical type: Peptide from protein
Sequence: NPDESSKPNMIDAATLKSRK
Position: 95-114
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SKPNMIDAATLKSRKM
Chemical type: Peptide from protein
Sequence: SKPNMIDAATLKSRKM
Position: 100-115
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SKPNMIDAATLKSRK
Chemical type: Peptide from protein
Sequence: SKPNMIDAATLKSRK
Position: 100-114
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: SKPNMIDAATLKSR
Chemical type: Peptide from protein
Sequence: SKPNMIDAATLKSR
Position: 100-113
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: KPNMIDAATLKSRK
Chemical type: Peptide from protein
Sequence: KPNMIDAATLKSRK
Position: 101-114
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: YQGGTYSKASTPNGYDNGI
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNGI
Position: 375-393
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: YQGGTYSKASTPNGYDNG
Chemical type: Peptide from protein
Sequence: YQGGTYSKASTPNGYDNG
Position: 375-392
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: QGGTYSKASTPNGYDNGI
Chemical type: Peptide from protein
Sequence: QGGTYSKASTPNGYDNGI
Position: 376-393
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: QGGTYSKASTPNGYDN
Chemical type: Peptide from protein
Sequence: QGGTYSKASTPNGYDN
Position: 376-391
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGTYSKASTPNGYDNGIIW
Chemical type: Peptide from protein
Sequence: GGTYSKASTPNGYDNGIIW
Position: 377-395
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGTYSKASTPNGYDNGI
Chemical type: Peptide from protein
Sequence: GGTYSKASTPNGYDNGI
Position: 377-393
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGTYSKASTPNGYDNG
Chemical type: Peptide from protein
Sequence: GGTYSKASTPNGYDNG
Position: 377-392
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGTYSKASTPNGYDN
Chemical type: Peptide from protein
Sequence: GGTYSKASTPNGYDN
Position: 377-391
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GGTYSKASTPNGYD
Chemical type: Peptide from protein
Sequence: GGTYSKASTPNGYD
Position: 377-390
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GTYSKASTPNGYDNG
Chemical type: Peptide from protein
Sequence: GTYSKASTPNGYDNG
Position: 378-392
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: GTYSKASTPNGYDN
Chemical type: Peptide from protein
Sequence: GTYSKASTPNGYDN
Position: 378-391
Source molecule (GenBank): P02679.3
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 63 355

Epitope: Cit Fib_A1
Chemical type: Peptide from protein
Sequence: DSGEGDFLAEGGVR
Assay category: MhcBinding
Result: Negative

Epitope: Cit Fib_A5
Chemical type: Peptide from protein
Sequence: LGEFVSETESRGSES
Position: 537-551
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Negative

Epitope: Cit Fib_A6
Chemical type: Peptide from protein
Sequence: YSKQFTSSTSYNRGDS
Position: 579-594
Source molecule (GenBank): P02671.2
Assay category: MhcBinding
Result: Positive-High