Reference: Niannian Lv; Peng Chen; Xiaobin Dai; Hu Xu; Ziheng Li; Zelin Shan; Jinqian Li; Fenglin Guo; Yuanfang Chen; Jiayi Li; Yiqian Huang; Guizhi Dong; Yifan Jiang; Liang Chen; Xuanyu Nan; Hanjun Zhao; Kang Zhang; Shilong Fan; Yuanchen Dong; Dongsheng Liu; Xinquan Wang; Deli Huang; Xiaojing Pan; Chunying Chen; Zhihua Liu; Li-Tang Yan; Qi Zhang; Linqi Zhang; Yuliang Zhao; Yuhe Renee Yang. "IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by a Low-Affinity Antibody." Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2025).

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 8.7

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 117000.0

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 256000.0

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 225.0

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0453

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 656000.0

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00101

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-High
Quantitative measurement: 0.0000792

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.39

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0000000518

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab P5-1C8 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R403, T415, G416, K417, D420, Y421, Y453, L455, F456, R457, K458, N460, Y473, Q474, A475, G476, S477, F486, N487, Y489, Q493, Y505
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive