Reference: Jeremy R Keown; Zihan Zhu; Loïc Carrique; Haitian Fan; Alexander P Walker; Itziar Serna Martin; Els Pardon; Jan Steyaert; Ervin Fodor; Jonathan M Grimes. "Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies." Nature communications (2022).

Epitope: Epitope of Nb8193 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: Q257, R264, R369, S387, G388, R389, D390, E391, I394, I461, I463, M467, P469, V480, K482, M483, G484, T521, Q522, G523, T524
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.68

Epitope: Epitope of Nb8194 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: G388, R389, D390, E391, Q392, I394, I461, I463, M467, P469, V480, K482, M483, G484
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive
Quantitative measurement: 1.88

Epitope: Epitope of Nb8194 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: G388, R389, D390, E391, Q392, I394, I461, I463, M467, P469, V480, K482, M483, G484
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8208 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: E391, I461, L464, P465, D466, M467, T468, P469, S470, T471, E472, K482
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.14

Epitope: Epitope of Nb8208 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: E391, I461, L464, P465, D466, M467, T468, P469, S470, T471, E472, K482
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8208 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: E391, I461, L464, P465, D466, M467, T468, P469, S470, T471, E472, K482
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8208 on capmidlink domain of Flu polymerase PB2
Chemical type: Discontinuous protein residues
Discontinuous residues: E391, I461, L464, P465, D466, M467, T468, P469, S470, T471, E472, K482
Source molecule (GenBank): Q3HM41.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8191 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S405, T528, R531, S624
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8191 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S405, T528, R531, S624
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8191 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S405, T528, R531, S624
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8191 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S405, T528, R531, S624
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8189 on Flu polymerase heterotrimer
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R673; B: K11
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8189 on Flu polymerase heterotrimer
Chemical type: Region on multi-chain protein
Discontinuous residues: A: R673; B: K11
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8205 on Flu polymerase heterotrimer
Chemical type: Region on multi-chain protein
Discontinuous residues: A: P295, E430, D431, E493, G494, R495, R496; B: R563, D565
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8205 on Flu polymerase heterotrimer
Chemical type: Region on multi-chain protein
Discontinuous residues: A: P295, E430, D431, E493, G494, R495, R496; B: R563, D565
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8192 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: N444
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8192 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: N444
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8192 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: N444
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8192 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: N444
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8196 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: T712, R716
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8201 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: K626, V628, R716
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8201 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: K626, V628, R716
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8203 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: C8
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8203 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: C8
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8204 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: R269, G684, E688
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8204 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: R269, G684, E688
Source molecule (GenBank): Q3HM39.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8207 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S98, H99, P100, E267, R287, K288, T291, N292
Source molecule (GenBank): Q3HM40.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8207 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S98, H99, P100, E267, R287, K288, T291, N292
Source molecule (GenBank): Q3HM40.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8207 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S98, H99, P100, E267, R287, K288, T291, N292
Source molecule (GenBank): Q3HM40.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Nb8207 on Flu polymerase heterotrimer
Chemical type: Discontinuous protein residues
Discontinuous residues: S98, H99, P100, E267, R287, K288, T291, N292
Source molecule (GenBank): Q3HM40.1
Assay category: BCell
Result: Positive