Reference: Kentaro Tohma; Lauren A Ford-Siltz; Joseph A Kendra; Gabriel I Parra. "Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII.4 noroviruses." Cell reports (2022).

Epitope: SY 2012 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: SY 2012 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, T340, D341, F375, E376, A377, N378
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, T340, D341, F375, E376, A377, N378
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: SY 2012 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, T340, D341, F375, E376, A377, N378
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, T340, D341, F375, E376, A377, N378
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site D
Chemical type: Peptide from protein
Sequence: STTHR
Position: 393-397
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive-Low
Host: F 5-6 weeks

Epitope: SY 2012 Site E
Chemical type: Discontinuous protein residues
Discontinuous residues: S407, R411, N412, T413, H414
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: SY 2012 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: SY 2012 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: SY 2012 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site I
Chemical type: Discontinuous protein residues
Discontinuous residues: F250, S255, Q504
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site I
Chemical type: Discontinuous protein residues
Discontinuous residues: F250, S255, Q504
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: FH 2004 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: A294, D295, T296, H297, N298, N368, N372, N373
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: FH 2004 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: A294, D295, T296, H297, N298, N368, N372, N373
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: A294, D295, T296, H297, N298, N368, N372, N373
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, G340, D341, F375, E376, T377, G378
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: FH 2004 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, G340, D341, F375, E376, T377, G378
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site C
Chemical type: Discontinuous protein residues
Discontinuous residues: R339, G340, D341, F375, E376, T377, G378
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site D
Chemical type: Peptide from protein
Sequence: NGTHQ
Position: 393-397
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: FH 2004 Site D
Chemical type: Peptide from protein
Sequence: NGTHQ
Position: 393-397
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site D
Chemical type: Peptide from protein
Sequence: NGTHQ
Position: 393-397
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site E
Chemical type: Discontinuous protein residues
Discontinuous residues: S407, R411, T412, G413, H414
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: SY 2012 Site AG
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site AG
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site AG
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site AG
Chemical type: Discontinuous protein residues
Discontinuous residues: T294, G295, S296, R297, N298, Y352, S355, A356, D357, A359, R364, E368, D372, H373
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: SY 2012 Site EG
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364, S407, R411, N412, T413, H414
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: SY 2012 Site EG
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, A359, R364, S407, R411, N412, T413, H414
Source molecule (GenBank): ANP93501.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site EG
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, D355, V356, H357, T359, S364, S407, R411, T412, G413, H414
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: FH 2004 Site EG
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, D355, V356, H357, T359, S364, S407, R411, T412, G413, H414
Source molecule (GenBank): ABG49509.1
Assay category: BCell
Result: Positive
Host: F 6-8 weeks

Epitope: GR 1996/HT 2004 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, S355, V356, H357, T359, S364
Source molecule (GenBank): ABW74540.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: GR 1996/HT 2004 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, S355, V356, H357, T359, S364
Source molecule (GenBank): ABW74540.1
Assay category: BCell
Result: Positive-Low
Host: F 5-6 weeks

Epitope: GR 1996/HT 2004 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, S355, V356, H357, T359, S364
Source molecule (GenBank): ABW74540.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: YE 2006 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: S352, S355, V356, H357, T359, R364
Source molecule (GenBank): ABL74391.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: DH 2006 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, P357, T359, S364
Source molecule (GenBank): ABL74395.1
Assay category: BCell
Result: Positive-Low
Host: F 5-6 weeks

Epitope: DH 2006 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, P357, T359, S364
Source molecule (GenBank): ABL74395.1
Assay category: BCell
Result: Negative
Host: F 5-6 weeks

Epitope: NO 2010 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, S359, R364
Source molecule (GenBank): ANP93411.1
Assay category: BCell
Result: Positive-Low
Host: F 5-6 weeks

Epitope: NO 2010 Site G
Chemical type: Discontinuous protein residues
Discontinuous residues: Y352, S355, A356, D357, S359, R364
Source molecule (GenBank): ANP93411.1
Assay category: BCell
Result: Positive-Low
Host: F 5-6 weeks

Epitope: GR 1996 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: A294, G295, S296, H297, D298, T368, N372, N373
Source molecule (GenBank): AAD40495.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: DH 2006 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: A294, G295, S296, R297, N298, S368, E372, N373
Source molecule (GenBank): ABL74395.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks

Epitope: NO 2010 Site A
Chemical type: Discontinuous protein residues
Discontinuous residues: P294, G295, S296, R297, N298, A368, D372, N373
Source molecule (GenBank): ANP93411.1
Assay category: BCell
Result: Positive
Host: F 5-6 weeks