Reference: Chang Liu; Daming Zhou; Aiste Dijokaite-Guraliuc; Piyada Supasa; Helen M E Duyvesteyn; Helen M Ginn; Muneeswaran Selvaraj; Alexander J Mentzer; Raksha Das; Thushan I de Silva; Thomas G Ritter; Megan Plowright; Thomas A H Newman; Lizzie Stafford; Barbara Kronsteiner; Nigel Temperton; Yuan Lui; Martin Fellermeyer; Philip Goulder; Paul Klenerman; Susanna J Dunachie; Michael I Barton; Mikhail A Kutuzov; Omer Dushek; Elizabeth E Fry; Juthathip Mongkolsapaya; Jingshan Ren; David I Stuart; Gavin R Screaton. "A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity." Cell reports. Medicine (2024).

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-Low

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-2 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, Y451, L453, F454, R455, K456, S457, N458, Y471, Q472, A473, G474, S475, F484, N485, Y487, Q491, Q496, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.7

Epitope: Epitope of Fab XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-6 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: D403, Q407, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, Y471, Q472, A473, G474, S475, N485, Y487
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.03

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-9 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, T413, G414, K415, D418, Y419, L453, F454, R455, K456, N458, Y471, Q472, A473, G474, S475, K476, N485, Y487, Q491, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-4 on BA.2.12.1 S
Chemical type: Discontinuous protein residues
Discontinuous residues: T342, R343, A345, S346, Y348, A349, N351, K437, L438, D439, S440, K441, V442, N445, Y446, N447, Y448, Q449, R463, I465, L489, R506
Source molecule (GenBank): UUB96491.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Fab XBB-7 on BA.2.86 S
Chemical type: Discontinuous protein residues
Discontinuous residues: S443, Y446, W449, L452, F453, Y470, A472, G473, N474, K480, P482, N483, Y485, F486, L488, Q489, S490, Y497
Source molecule (GenBank): WMX20669.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of Nb C1 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: Y367, N368, S369, F372, S373, T374, F375, K376, C377, Y378, G379, V380, S381, P382, T383, K384, G402, D403, R406, V501, G502, Y506
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive
Quantitative measurement: 2.3

Epitope: Epitope of Fab Beta-49 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: T331, N332, L333, C334, P335, F336, G337, E338, F340, N341, T343, V360, A361, D362, Y363, V365, L366
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive
Quantitative measurement: 3.7

Epitope: Epitope of VHH anti-kappa on mAb XBB-9
Chemical type: Discontinuous protein residues
Discontinuous residues: K112, R113, T114, V115, Y145, P146, E148, K150, T202, H203, Q204, L206, S207
Source molecule (GenBank): Q0KKI6.1
Assay category: BCell
Result: Positive
Quantitative measurement: 4.03

Epitope: Epitope of Fab BA.2-23 on Delta RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R401, D403, T413, G414, K415, D418, Y419, L453, F454, R455, K456, S457, N458, Y471, A473, G474, F484, N485, Y487, Q491, N499, G500, Y503
Source molecule (GenBank): UEO57867.1
Assay category: BCell
Result: Positive

Epitope: Epitope of AZD1061 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, L441, S443, K444, V445, G446, Y449, N450, L452, E484, F490, Q493, S494, P499
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of AZD1061 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N439, N440, L441, S443, K444, V445, G446, Y449, N450, L452, E484, F490, Q493, S494, P499
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of AZD8895 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: L455, A475, G476, S477, T478, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate

Epitope: Epitope of AZD8895 on SARS-CoV-2 S
Chemical type: Discontinuous protein residues
Discontinuous residues: L455, A475, G476, S477, T478, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-High

Epitope: Epitope of REGN10987 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: R346, N440, L441, K444, V445, G446, N448, Y449, Q498
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive

Epitope: Epitope of REGN10933 on SARS-CoV2 RBD
Chemical type: Discontinuous protein residues
Discontinuous residues: K417, Y453, L455, F456, E484, G485, F486, N487, C488, Y489, Q493
Source molecule (GenBank): P0DTC2.1
Assay category: BCell
Result: Positive-Intermediate