Reference: Amir A Al-Khami; Sawsan Youssef; Yasmina Abdiche; HoangKim Nguyen; Joyce Chou; Christopher R Kimberlin; Sherman M Chin; Cris Kamperschroer; Bart Jessen; Brent Kern; Natalija Budimir; Christopher P Dillon; Allison Xu; Jerry D Clark; Jeffrey Chou; Eugenia Kraynov; Arvind Rajpal; John C Lin; Shahram Salek-Ardakani. "Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody." Molecular cancer therapeutics (2020).

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.05104

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.08534

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Negative

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000029

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 900.0

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 6000.0

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive-Low
Quantitative measurement: 0.0052

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000018

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.59

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.042

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 420000.0

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.069

Epitope: Epitope of sasanlimab on PD-1
Chemical type: Discontinuous protein residues
Discontinuous residues: V64, N66, Y68, S71, Q75, T76, D77, K78, D85, S87, Q88, P89, G90, I126, L128, A129, P130, A132, Q133, I134, E136
Source molecule (GenBank): NP_005009.2
Assay category: BCell
Result: Positive
Quantitative measurement: 430000.0