Reference: Cliff Rims; Hannes Uchtenhagen; Mariana J Kaplan; Carmelo Carmona-Rivera; Philip Carlucci; Katalin Mikecz; Adrienn Markovics; Jeffrey Carlin; Jane H Buckner; Eddie A James. "Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis." Arthritis & rheumatology (Hoboken, N.J.) (2019).

Epitope: Aggrecan 200–215 Cit
Chemical type: Peptide from protein
Sequence: DAGWLADQTVRYPIHT
Position: 200-215
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 200–215 Cit
Chemical type: Peptide from protein
Sequence: DAGWLADQTVRYPIHT
Position: 200-215
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 200–215 Cit
Chemical type: Peptide from protein
Sequence: DAGWLADQTVRYPIHT
Position: 200-215
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 200–215 Cit
Chemical type: Peptide from protein
Sequence: DAGWLADQTVRYPIHT
Position: 200-215
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2950.0

Epitope: Aggrecan 225–244 Cit
Chemical type: Peptide from protein
Sequence: DEFPGVRTYGIRDTNETYDV
Position: 225-244
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 225–244 Cit
Chemical type: Peptide from protein
Sequence: DEFPGVRTYGIRDTNETYDV
Position: 225-244
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 225–244 Cit
Chemical type: Peptide from protein
Sequence: DEFPGVRTYGIRDTNETYDV
Position: 225-244
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 225–244 Cit
Chemical type: Peptide from protein
Sequence: DEFPGVRTYGIRDTNETYDV
Position: 225-244
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2180.0

Epitope: Aggrecan 161–178 Cit
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 161–178 Cit
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 161–178 Cit
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 161–178 Cit
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 990.0

Epitope: Aggrecan 520 Cit
Chemical type: Peptide from protein
Sequence: GYEQCDAGWLRDQTVRYPIV
Position: 520-539
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 520 Cit
Chemical type: Peptide from protein
Sequence: GYEQCDAGWLRDQTVRYPIV
Position: 520-539
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 520 Cit
Chemical type: Peptide from protein
Sequence: GYEQCDAGWLRDQTVRYPIV
Position: 520-539
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 520 Cit
Chemical type: Peptide from protein
Sequence: GYEQCDAGWLRDQTVRYPIV
Position: 520-539
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 12620.0

Epitope: Aggrecan 553 Cit
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 553 Cit
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 553 Cit
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 553 Cit
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive-Low
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 553 Cit
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 7960.0

Epitope: Aggrecan 621 Cit
Chemical type: Peptide from protein
Sequence: KCYAGWLADGSLRYPIV
Position: 620-636
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 621 Cit
Chemical type: Peptide from protein
Sequence: KCYAGWLADGSLRYPIV
Position: 620-636
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: Aggrecan 621 Cit
Chemical type: Peptide from protein
Sequence: KCYAGWLADGSLRYPIV
Position: 620-636
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 621 Cit
Chemical type: Peptide from protein
Sequence: KCYAGWLADGSLRYPIV
Position: 620-636
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 6900.0

Epitope: Aggrecan 3-20 Cit
Chemical type: Peptide from protein
Sequence: TLLWVFVTLRVITAAVTV
Position: 3-20
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 3-20 Cit
Chemical type: Peptide from protein
Sequence: TLLWVFVTLRVITAAVTV
Position: 3-20
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 35300.0

Epitope: Aggrecan 153–168 Cit
Chemical type: Peptide from protein
Sequence: IVFHYRAISTRYTLDF
Position: 153-168
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 153–168 Cit
Chemical type: Peptide from protein
Sequence: IVFHYRAISTRYTLDF
Position: 153-168
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 980.0

Epitope: Aggrecan 477 Cit
Chemical type: Peptide from protein
Sequence: GVVFHYRPGPTRYSLTF
Position: 477-493
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 477 Cit
Chemical type: Peptide from protein
Sequence: GVVFHYRPGPTRYSLTF
Position: 477-493
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 14690.0

Epitope: Aggrecan 568 Cit
Chemical type: Peptide from protein
Sequence: DVYCFVDRLEGEVFFA
Position: 568-583
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 568 Cit
Chemical type: Peptide from protein
Sequence: DVYCFVDRLEGEVFFA
Position: 568-583
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 23420.0

Epitope: Aggrecan 579 Cit
Chemical type: Peptide from protein
Sequence: EVFFATRLEQFTFQE
Position: 579-593
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 579 Cit
Chemical type: Peptide from protein
Sequence: EVFFATRLEQFTFQE
Position: 579-593
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 78430.0

Epitope: Aggrecan 684 Cit
Chemical type: Peptide from protein
Sequence: NSPFCLERTPLGSPDPA
Position: 684-700
Source molecule (GenBank): Q6PID9.1
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 684 Cit
Chemical type: Peptide from protein
Sequence: NSPFCLERTPLGSPDPA
Position: 684-700
Source molecule (GenBank): Q6PID9.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 120.0

Epitope: Aggrecan 298–313 Cit
Chemical type: Peptide from protein
Sequence: SAGWLADRSVRYPISK
Position: 298-313
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 298–313 Cit
Chemical type: Peptide from protein
Sequence: SAGWLADRSVRYPISK
Position: 298-313
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1900.0

Epitope: Aggrecan 161–178 Arg
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 161–178 Arg
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Aggrecan 161–178 Arg
Chemical type: Peptide from protein
Sequence: STRYTLDFDRAQRACLQ
Position: 161-177
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1020.0

Epitope: Aggrecan 3-20 Arg
Chemical type: Peptide from protein
Sequence: TLLWVFVTLRVITAAVTV
Position: 3-20
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 36060.0

Epitope: Aggrecan 153–168 Arg
Chemical type: Peptide from protein
Sequence: IVFHYRAISTRYTLDF
Position: 153-168
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 50960.0

Epitope: Aggrecan 200–215 Arg
Chemical type: Peptide from protein
Sequence: DAGWLADQTVRYPIHT
Position: 200-215
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2530.0

Epitope: Aggrecan 225–244 Arg
Chemical type: Peptide from protein
Sequence: DEFPGVRTYGIRDTNETYDV
Position: 225-244
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: Aggrecan 298–313 Arg
Chemical type: Peptide from protein
Sequence: SAGWLADRSVRYPISK
Position: 298-313
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2940.0

Epitope: Aggrecan 477 Arg
Chemical type: Peptide from protein
Sequence: GVVFHYRPGPTRYSLTF
Position: 477-493
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: Aggrecan 520 Arg
Chemical type: Peptide from protein
Sequence: GYEQCDAGWLRDQTVRYPIV
Position: 520-539
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 15610.0

Epitope: Aggrecan 553 Arg
Chemical type: Peptide from protein
Sequence: PGVRTYGVRPSTETYDVY
Position: 553-570
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: Aggrecan 568 Arg
Chemical type: Peptide from protein
Sequence: DVYCFVDRLEGEVFFA
Position: 568-583
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 3060.0

Epitope: Aggrecan 579 Arg
Chemical type: Peptide from protein
Sequence: EVFFATRLEQFTFQE
Position: 579-593
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 15330.0

Epitope: Aggrecan 621 Arg
Chemical type: Peptide from protein
Sequence: KCYAGWLADGSLRYPIV
Position: 620-636
Source molecule (GenBank): P16112.2
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 4660.0

Epitope: Aggrecan 684 Arg
Chemical type: Peptide from protein
Sequence: NSPFCLERTPLGSPDPA
Position: 684-700
Source molecule (GenBank): Q6PID9.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 130.0