Reference: Swetha Raman; Melissa Beilschmidt; Minh To; Kevin Lin; Francine Lui; Yazen Jmeian; Mark Ng; Minerva Fernandez; Ying Fu; Keith Mascall; Alejandro Duque; Xiaowei Wang; Guohua Pan; Stephane Angers; Jason Moffat; Sachdev S Sidhu; Jeanne Magram; Angus M Sinclair; Johan Fransson; Jean-Philippe Julien. "Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies." Proceedings of the National Academy of Sciences of the United States of America (2019).

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.3

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 4.5

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 320000.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00011

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 590000.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0026

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.7

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 340000.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00057

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.6

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.5

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.7

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.55

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.39

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 230000.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 2.9

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00030

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.8

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 1.3

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 3.5

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.00040

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 330000.0

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0012

Epitope: Epitope of F2.1 Fab on FZD5
Chemical type: Discontinuous protein residues
Discontinuous residues: H57, E62, G64, L65, E66, H68, Q69, F70, W71, P72, L73, E75, M120, Y123, F125, P128, R130
Source molecule (GenBank): Q13467.2
Assay category: BCell
Result: Positive
Quantitative measurement: 220000.0