Reference: Ronit Mazor; Devorah Crown; Selamawit Addissie; Youjin Jang; Gilad Kaplan; Ira Pastan. "Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo." Cellular & molecular immunology (2017).

Epitope: P23
Chemical type: Peptide from protein
Sequence: SPGSGGDLGEAIREQ
Position: 330-344
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P34
Chemical type: Peptide from protein
Sequence: VRQGTGNDEAGAANG
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P36
Chemical type: Peptide from protein
Sequence: NDEAGAANGPADSGD
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P53
Chemical type: Peptide from protein
Sequence: QAHRQLEERGYVFVG
Position: 436-450
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P61
Chemical type: Peptide from protein
Sequence: QSIVFGGVRARSQDL
Position: 460-474
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P74
Chemical type: Peptide from protein
Sequence: PDARGRIRNGALLRV
Position: 499-513
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P75
Chemical type: Peptide from protein
Sequence: RGRIRNGALLRVYVP
Position: 502-516
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P80
Chemical type: Peptide from protein
Sequence: RSSLPGFYRTSLTLA
Position: 530-544
Source molecule (GenBank): WP_039027124.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P84
Chemical type: Peptide from protein
Sequence: TLAAPEAAGEVERLI
Position: 529-543
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: P105
Chemical type: Peptide from protein
Sequence: GDLDPSSIPDKEQAI
Position: 592-606
Source molecule (GenBank): WP_044305324.1
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: LMB-T20 P54
Chemical type: Peptide, no natural source
Sequence: AQLEERGYVFVGYHG
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: LMB-T20 P56
Chemical type: Peptide, no natural source
Sequence: GYVFVGYHGTALEAA
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: LMB-T20 P74
Chemical type: Peptide, no natural source
Sequence: PDARGRIANGALLRV
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: LMB-T20 P94
Chemical type: Peptide, no natural source
Sequence: EEGGREETILGWPLA
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: 13-15 G288A
Chemical type: Peptide, no natural source
Sequence: AYPVQRLVALYLAARLSWNQV
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: 57-58 F436A
Chemical type: Peptide, no natural source
Sequence: AVGYHGTFLEAAQSIVFG
Assay category: TCell
Result: Positive
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: 57-58 F443A
Chemical type: Peptide, no natural source
Sequence: FVGYHGTALEAAQSIVFG
Assay category: TCell
Result: Negative
Host: F 6-8 weeks
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo