Reference: E A James; S D van Haren; R A Ettinger; K Fijnvandraat; J A Liberman; W W Kwok; J Voorberg; K P Pratt. "T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site." Journal of thrombosis and haemostasis : JTH (2011).

Epitope: FVIII-A2 529-548
Chemical type: Peptide from protein
Sequence: LTRYYSSFVNMERDLASGLI
Position: 529-548
Source molecule (GenBank): 3CDZ_A
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: FVIII-A2 529-548
Chemical type: Peptide from protein
Sequence: LTRYYSSFVNMERDLASGLI
Position: 529-548
Source molecule (GenBank): 3CDZ_A
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 200.0

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 50000.0

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 581-600, 593C
Chemical type: Peptide, no natural source
Sequence: ENRSWYLTENIQCFLPNPAG
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 56000.0

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 8300.0

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Negative

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1500.0

Epitope: FVIII-A2 589-608, 593C
Chemical type: Peptide, no natural source
Sequence: ENIQCFLPNPAGVQLEDPEF
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 9800.0

Epitope: FVIII-A2 610-629
Chemical type: Peptide from protein
Sequence: ASNIMHSINGYVFDSLQLSV
Position: 610-629
Source molecule (GenBank): 3CDZ_A
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: FVIII-A2 610-629
Chemical type: Peptide from protein
Sequence: ASNIMHSINGYVFDSLQLSV
Position: 610-629
Source molecule (GenBank): 3CDZ_A
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: FVIII-A2 445-464
Chemical type: Peptide from protein
Sequence: ESGILGPLLYGEVGDTLLII
Position: 445-464
Source molecule (GenBank): 3CDZ_A
Assay category: TCell
Result: Negative
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated