Reference: Perrin Guyer; David Arribas-Layton; Anthony Manganaro; Cate Speake; Sandra Lord; Decio L Eizirik; Sally C Kent; Roberto Mallone; Eddie A James. "Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes." Diabetes (2023).

Epitope: CCNI-008 p2
Chemical type: Peptide from protein
Sequence: MERIILDKLNWDLHT
Position: 130-144
Source molecule (GenBank): Q14094.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: GAD2-003 p2
Chemical type: Peptide from protein
Sequence: KTGIVSSKIIKLFFR
Position: 172-186
Source molecule (GenBank): Q5VZ31.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: GNAS-036 p15
Chemical type: Peptide from protein
Sequence: SNEYQLIDCAQYFLD
Position: 167-181
Source molecule (GenBank): P63092-4
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 38600.0

Epitope: REXO2-020 p2
Chemical type: Peptide, no natural source
Sequence: VKYYSRNSVHEDKKF
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: SCG5-009 p3
Chemical type: Peptide from protein
Sequence: GDAWSFLSGAVNRLK
Position: 181-195
Source molecule (GenBank): H7C4X7.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: SCG5 p13
Chemical type: Peptide from protein
Sequence: TAEFSREFQLHQHLF
Position: 136-150
Source molecule (GenBank): P05408-2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 50.0

Epitope: PCSK2 p3
Chemical type: Peptide from protein
Sequence: GFLFCVMVFASAERP
Position: 14-28
Source molecule (GenBank): P16519.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p19
Chemical type: Peptide from protein
Sequence: YPRYTDDWFNSHGTR
Position: 178-192
Source molecule (GenBank): P16519-3
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p21
Chemical type: Peptide from protein
Sequence: AGEVSAAANNNICGV
Position: 178-192
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: TCell
Result: Positive
Host:  23-40 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: TCell
Result: Positive
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: TCell
Result: Positive
MHC allele types: 57 407
Host: F 10 years
Cell type: T cell CD4+
Tissue: pancreas
Culture conditions: Direct Ex Vivo

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: TCell
Result: Positive
Host:  23-70 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: TCell
Result: Positive-Low
Host:  22-67 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: PCSK2 p23
Chemical type: Peptide from protein
Sequence: QPFMTDIIEASSISH
Position: 208-222
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 70.0

Epitope: PCSK2 p33
Chemical type: Peptide from protein
Sequence: TALYDESCSSTLAST
Position: 305-319
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 40.0

Epitope: PCSK2 p43
Chemical type: Peptide from protein
Sequence: AKDWKTVPERFHCVG
Position: 421-435
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p45
Chemical type: Peptide from protein
Sequence: TGKLVLTLTTDACEG
Position: 447-461
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 2900.0

Epitope: PCSK2 p47
Chemical type: Peptide from protein
Sequence: VRYLEHVQAVITVN
Position: 501-514
Source molecule (GenBank): P16519.2
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p51
Chemical type: Peptide from protein
Sequence: KVGFDKWPFMTTHTW
Position: 511-525
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0

Epitope: PCSK2 p55
Chemical type: Peptide from protein
Sequence: ELGFVGSAPQKGVLK
Position: 536-550
Source molecule (GenBank): P16519-2.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 50000.0