Reference: Michael D Knierman; Megan B Lannan; Laura J Spindler; Carl L McMillian; Robert J Konrad; Robert W Siegel. "The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein." Cell reports (2020).

Epitope: SSVLHSTQDLFLPF
Chemical type: Peptide from protein
Sequence: SSVLHSTQDLFLPF
Position: 45-58
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 422 424 425

Epitope: EFQFCNDPFLGVYYH
Chemical type: Peptide from protein
Sequence: EFQFCNDPFLGVYYH
Position: 132-146
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 436 422 437 354 430 408 425 424 419 413

Epitope: CEFQFCNDPFLGVYYHK
Chemical type: Peptide from protein
Sequence: CEFQFCNDPFLGVYYHK
Position: 131-147
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 422 437 354 424 425 419

Epitope: TFEYVSQPFLMDL
Chemical type: Peptide from protein
Sequence: TFEYVSQPFLMDL
Position: 167-179
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354 424 425

Epitope: FEYVSQPFLMDLE
Chemical type: Peptide from protein
Sequence: FEYVSQPFLMDLE
Position: 168-180
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354 424 425

Epitope: TFEYVSQPFLMDLEGK
Chemical type: Peptide from protein
Sequence: TFEYVSQPFLMDLEGK
Position: 167-182
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425 419

Epitope: EFVFKNIDGYFK
Chemical type: Peptide from protein
Sequence: EFVFKNIDGYFK
Position: 191-202
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: HTPINLVRDLPQGF
Chemical type: Peptide from protein
Sequence: HTPINLVRDLPQGF
Position: 207-220
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: TPINLVRDLPQG
Chemical type: Peptide from protein
Sequence: TPINLVRDLPQG
Position: 208-219
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: ITRFQTLLALHRS
Chemical type: Peptide from protein
Sequence: ITRFQTLLALHRS
Position: 235-247
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: AAYYVGYLQPR
Chemical type: Peptide from protein
Sequence: AAYYVGYLQPR
Position: 263-273
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: ITDAVDCALDPLSE
Chemical type: Peptide from protein
Sequence: ITDAVDCALDPLSE
Position: 285-298
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: LKSFTVEKGIYQTS
Chemical type: Peptide from protein
Sequence: LKSFTVEKGIYQTS
Position: 303-316
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 419

Epitope: FASVYAWNRKRIS
Chemical type: Peptide from protein
Sequence: FASVYAWNRKRIS
Position: 347-359
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: NRKRISNCVADYSVLYN
Chemical type: Peptide from protein
Sequence: NRKRISNCVADYSVLYN
Position: 354-370
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: YNSASFSTFKCYGVSPT
Chemical type: Peptide from protein
Sequence: YNSASFSTFKCYGVSPT
Position: 369-385
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: YNSASFSTFKCYGVSPTKL
Chemical type: Peptide from protein
Sequence: YNSASFSTFKCYGVSPTKL
Position: 369-387
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: STFKCYGVSPT
Chemical type: Peptide from protein
Sequence: STFKCYGVSPT
Position: 375-385
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: LPDDFTGCVIAWNSNNLDSKVG
Chemical type: Peptide from protein
Sequence: LPDDFTGCVIAWNSNNLDSKVG
Position: 425-446
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: DFTGCVIAWNSNNLDSK
Chemical type: Peptide from protein
Sequence: DFTGCVIAWNSNNLDSK
Position: 428-444
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 424 425

Epitope: TGCVIAWNSNNLD
Chemical type: Peptide from protein
Sequence: TGCVIAWNSNNLD
Position: 430-442
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: GCVIAWNSNNLDS
Chemical type: Peptide from protein
Sequence: GCVIAWNSNNLDS
Position: 431-443
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 424 425 419

Epitope: GCVIAWNSNNLDSK
Chemical type: Peptide from protein
Sequence: GCVIAWNSNNLDSK
Position: 431-444
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 424 425 419

Epitope: PDDFTGCVIAWNSNNLDSK
Chemical type: Peptide from protein
Sequence: PDDFTGCVIAWNSNNLDSK
Position: 426-444
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: NYNYLYRLFRKSNL
Chemical type: Peptide from protein
Sequence: NYNYLYRLFRKSNL
Position: 448-461
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: VGGNYNYLYRLFRK
Chemical type: Peptide from protein
Sequence: VGGNYNYLYRLFRK
Position: 445-458
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425 419

Epitope: YNYLYRLFRKSNLKPFER
Chemical type: Peptide from protein
Sequence: YNYLYRLFRKSNLKPFER
Position: 449-466
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: NYLYRLFRKSNLKPF
Chemical type: Peptide from protein
Sequence: NYLYRLFRKSNLKPF
Position: 450-464
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: GNYNYLYRL
Chemical type: Peptide from protein
Sequence: GNYNYLYRL
Position: 447-455
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 419

Epitope: RDISTEIYQAGSTPCNG
Chemical type: Peptide from protein
Sequence: RDISTEIYQAGSTPCNG
Position: 466-482
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 407 408

Epitope: DISTEIYQAGSTPCNG
Chemical type: Peptide from protein
Sequence: DISTEIYQAGSTPCNG
Position: 467-482
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 407 408

Epitope: ISTEIYQAGSTPCNG
Chemical type: Peptide from protein
Sequence: ISTEIYQAGSTPCNG
Position: 468-482
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 407 408

Epitope: ERDISTEIYQAGSTPCNG
Chemical type: Peptide from protein
Sequence: ERDISTEIYQAGSTPCNG
Position: 465-482
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: QPYRVVVLSFELLHAPA
Chemical type: Peptide from protein
Sequence: QPYRVVVLSFELLHAPA
Position: 506-522
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354 424 425

Epitope: NGLTGTGVLTESNKK
Chemical type: Peptide from protein
Sequence: NGLTGTGVLTESNKK
Position: 544-558
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: SNKKFLPFQQFGRD
Chemical type: Peptide from protein
Sequence: SNKKFLPFQQFGRD
Position: 555-568
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354 424 425

Epitope: KKFLPFQQFGRDIAD
Chemical type: Peptide from protein
Sequence: KKFLPFQQFGRDIAD
Position: 557-571
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: SYQTQTNSPRRAASVASQSIIA
Chemical type: Peptide from protein
Sequence: SYQTQTNSPRRAASVASQSIIA
Position: 673-694
Source molecule (GenBank): 6ZB4_A
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 422 413 414 419

Epitope: QTQTNSPRRAASVASQSIIA
Chemical type: Peptide from protein
Sequence: QTQTNSPRRAASVASQSIIA
Position: 675-694
Source molecule (GenBank): 6ZB4_A
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 422 413 414 408 425 424 419

Epitope: TNSPRRAASVASQSIIA
Chemical type: Peptide from protein
Sequence: TNSPRRAASVASQSIIA
Position: 678-694
Source molecule (GenBank): 6ZB4_A
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 422 413 414 407 408 424 425 419

Epitope: ASQSIIAYTMSLG
Chemical type: Peptide from protein
Sequence: ASQSIIAYTMSLG
Position: 688-700
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436

Epitope: SNLLLQYGSFCTQ
Chemical type: Peptide from protein
Sequence: SNLLLQYGSFCTQ
Position: 750-762
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: LLQYGSFCTQLNR
Chemical type: Peptide from protein
Sequence: LLQYGSFCTQLNR
Position: 753-765
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: QLNRALTGIAVEQD
Chemical type: Peptide from protein
Sequence: QLNRALTGIAVEQD
Position: 762-775
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: NTQEVFAQVKQIYKTPP
Chemical type: Peptide from protein
Sequence: NTQEVFAQVKQIYKTPP
Position: 777-793
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: TQEVFAQVKQIYKTPP
Chemical type: Peptide from protein
Sequence: TQEVFAQVKQIYKTPP
Position: 778-793
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: RSFIEDLLFNKVT
Chemical type: Peptide from protein
Sequence: RSFIEDLLFNKVT
Position: 815-827
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354 407 408 424 425

Epitope: AGFIKQYGDCLGDI
Chemical type: Peptide from protein
Sequence: AGFIKQYGDCLGDI
Position: 831-844
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: AGFIKQYGDCLGDIAA
Chemical type: Peptide from protein
Sequence: AGFIKQYGDCLGDIAA
Position: 831-846
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: TDEMIAQYTSALLA
Chemical type: Peptide from protein
Sequence: TDEMIAQYTSALLA
Position: 866-879
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: TDEMIAQYTSALLA
Chemical type: Peptide from protein
Sequence: TDEMIAQYTSALLA
Position: 866-879
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354

Epitope: DEMIAQYTSAL
Chemical type: Peptide from protein
Sequence: DEMIAQYTSAL
Position: 867-877
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436

Epitope: DEMIAQYTSALLAG
Chemical type: Peptide from protein
Sequence: DEMIAQYTSALLAG
Position: 867-880
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 430

Epitope: DEMIAQYTSALLAG
Chemical type: Peptide from protein
Sequence: DEMIAQYTSALLAG
Position: 867-880
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 430

Epitope: MIAQYTSALLAGT
Chemical type: Peptide from protein
Sequence: MIAQYTSALLAGT
Position: 869-881
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436

Epitope: EMIAQYTSALLAGTIT
Chemical type: Peptide from protein
Sequence: EMIAQYTSALLAGTIT
Position: 868-883
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: QIPFAMQMAYRFNG
Chemical type: Peptide from protein
Sequence: QIPFAMQMAYRFNG
Position: 895-908
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 437 354 430

Epitope: LQIPFAMQMAYRFNGIG
Chemical type: Peptide from protein
Sequence: LQIPFAMQMAYRFNGIG
Position: 894-910
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: QNVLYENQKLIANQFNS
Chemical type: Peptide from protein
Sequence: QNVLYENQKLIANQFNS
Position: 913-929
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 422 419

Epitope: NDILSRLDKVEAEVQ
Chemical type: Peptide from protein
Sequence: NDILSRLDKVEAEVQ
Position: 978-992
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 422 419

Epitope: VQIDRLITGRLQSLQTYV
Chemical type: Peptide from protein
Sequence: VQIDRLITGRLQSLQTYV
Position: 991-1008
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: QQLIRAAEIRASAN
Chemical type: Peptide from protein
Sequence: QQLIRAAEIRASAN
Position: 1010-1023
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: GTHWFVTQRNFYEPQI
Chemical type: Peptide from protein
Sequence: GTHWFVTQRNFYEPQI
Position: 1099-1114
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 413 436 407 408

Epitope: VSNGTHWFVTQRNFYEPQII
Chemical type: Peptide from protein
Sequence: VSNGTHWFVTQRNFYEPQII
Position: 1096-1115
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: NGTHWFVTQRNFYEPQ
Chemical type: Peptide from protein
Sequence: NGTHWFVTQRNFYEPQ
Position: 1098-1113
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408

Epitope: HWFVTQRNFYEPQ
Chemical type: Peptide from protein
Sequence: HWFVTQRNFYEPQ
Position: 1101-1113
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 407 408 425

Epitope: DISGINASVVNIQK
Chemical type: Peptide from protein
Sequence: DISGINASVVNIQK
Position: 1168-1181
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354

Epitope: LGKYEQYIKWP
Chemical type: Peptide from protein
Sequence: LGKYEQYIKWP
Position: 1203-1213
Source molecule (GenBank): YP_009724390.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 424 425

Epitope: LQIPFAMQMAYRFNGIG
Chemical type: Peptide from protein
Sequence: LQIPFAMQMAYRFNGIG
Position: 876-892
Source molecule (GenBank): P59594.1
Assay category: MhcLigandElution
Result: Positive
MHC allele types: 437 354