Reference: Hidefumi Inaba; William Martin; Matt Ardito; Anne Searls De Groot; Leslie J De Groot. "The role of glutamic or aspartic acid in position four of the epitope binding motif and thyrotropin receptor-extracellular domain epitope selection in Graves' disease." The Journal of clinical endocrinology and metabolism (2010).

Epitope: TSHR-ECD 119-137 No.9
Chemical type: Peptide from protein
Sequence: PDALKELPLLKFLGIFNTG
Position: 119-137
Source molecule (GenBank): AAI27629.1
Assay category: TCell
Result: Negative
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR-ECD 119-137 No.9
Chemical type: Peptide from protein
Sequence: PDALKELPLLKFLGIFNTG
Position: 119-137
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: TSHR-ECD 119-137 No.9
Chemical type: Peptide from protein
Sequence: PDALKELPLLKFLGIFNTG
Position: 119-137
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 18300.0

Epitope: TSHR-ECD 119-137 No.9
Chemical type: Peptide from protein
Sequence: PDALKELPLLKFLGIFNTG
Position: 119-137
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: TSHR-ECD 207-222 No.16
Chemical type: Peptide from protein
Sequence: LNKNKYLTVIDKDAFG
Position: 207-222
Source molecule (GenBank): AAI27629.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR-ECD 207-222 No.16
Chemical type: Peptide from protein
Sequence: LNKNKYLTVIDKDAFG
Position: 207-222
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 40000.0

Epitope: TSHR-ECD 207-222 No.16
Chemical type: Peptide from protein
Sequence: LNKNKYLTVIDKDAFG
Position: 207-222
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 40000.0

Epitope: TSHR-ECD 207-222 No.16
Chemical type: Peptide from protein
Sequence: LNKNKYLTVIDKDAFG
Position: 207-222
Source molecule (GenBank): AAI27629.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 73000.0

Epitope: TSHR-ECD 272-291 No.22
Chemical type: Peptide from protein
Sequence: LTRADLSYPSHCCAFKNQKK
Position: 272-291
Source molecule (GenBank): AAA36783.1
Assay category: TCell
Result: Positive
Cell type: splenocyte
Tissue: spleen
Culture conditions: Direct Ex Vivo

Epitope: TSHR-ECD 272-291 No.22
Chemical type: Peptide from protein
Sequence: LTRADLSYPSHCCAFKNQKK
Position: 272-291
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 14200.0

Epitope: TSHR-ECD 272-291 No.22
Chemical type: Peptide from protein
Sequence: LTRADLSYPSHCCAFKNQKK
Position: 272-291
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 30000.0

Epitope: TSHR-ECD 272-291 No.22
Chemical type: Peptide from protein
Sequence: LTRADLSYPSHCCAFKNQKK
Position: 272-291
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 71300.0

Epitope: TSHR-ECD 137-150 No.33
Chemical type: Peptide from protein
Sequence: GLKMFPDLTKVYST
Position: 137-150
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 200.0

Epitope: TSHR-ECD 137-150 No.33
Chemical type: Peptide from protein
Sequence: GLKMFPDLTKVYST
Position: 137-150
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 10500.0

Epitope: TSHR-ECD 137-150 No.33
Chemical type: Peptide from protein
Sequence: GLKMFPDLTKVYST
Position: 137-150
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 25000.0

Epitope: TSHR-ECD 339-352 No.35
Chemical type: Peptide from protein
Sequence: EKSKFQDTHNNAHY
Position: 339-352
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-Intermediate
Quantitative measurement: 37500.0

Epitope: TSHR-ECD 339-352 No.35
Chemical type: Peptide from protein
Sequence: EKSKFQDTHNNAHY
Position: 339-352
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 8500.0

Epitope: TSHR-ECD 339-352 No.35
Chemical type: Peptide from protein
Sequence: EKSKFQDTHNNAHY
Position: 339-352
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 100000.0

Epitope: TSHR-ECD 266-284 No.40
Chemical type: Peptide from protein
Sequence: SLSFLHLTRADLSYPSHCC
Position: 266-284
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 5000.0

Epitope: TSHR-ECD 266-284 No.40
Chemical type: Peptide from protein
Sequence: SLSFLHLTRADLSYPSHCC
Position: 266-284
Source molecule (GenBank): AAA36783.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 4000.0