Reference: Xinyi Jiang; Qin Qin; Haixia Zhu; Jiaqiang Qian; Qiang Huang. "Structure-guided design of a trivalent nanobody cluster targeting SARS-CoV-2 spike protein." International journal of biological macromolecules (2024).

Epitope: Epitope of nanobody Nb6 Tribody on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T109, K113, A163, N164, N165, C166, T333, L335, F338, G339, F342, N343, A344, V362, D364, S366, V367, N370, A372, N388, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, Q498, P499, T500, N501, V503, P507, V511, P527; B: R403, D405, E406, K417, I418, K444, G447, N448, Y449, N450, L452, I468, S469, T470, Y489, F490, P491, L492, Q493, S494, Y495, G496, F497, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive

Epitope: Epitope of nanobody Nb6 Tribody on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T109, K113, A163, N164, N165, C166, T333, L335, F338, G339, F342, N343, A344, V362, D364, S366, V367, N370, A372, N388, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, Q498, P499, T500, N501, V503, P507, V511, P527; B: R403, D405, E406, K417, I418, K444, G447, N448, Y449, N450, L452, I468, S469, T470, Y489, F490, P491, L492, Q493, S494, Y495, G496, F497, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.0010

Epitope: Epitope of nanobody Nb6 Tribody on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T109, K113, A163, N164, N165, C166, T333, L335, F338, G339, F342, N343, A344, V362, D364, S366, V367, N370, A372, N388, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, Q498, P499, T500, N501, V503, P507, V511, P527; B: R403, D405, E406, K417, I418, K444, G447, N448, Y449, N450, L452, I468, S469, T470, Y489, F490, P491, L492, Q493, S494, Y495, G496, F497, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 696000.0

Epitope: Epitope of nanobody Nb6 Tribody on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T109, K113, A163, N164, N165, C166, T333, L335, F338, G339, F342, N343, A344, V362, D364, S366, V367, N370, A372, N388, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, Q498, P499, T500, N501, V503, P507, V511, P527; B: R403, D405, E406, K417, I418, K444, G447, N448, Y449, N450, L452, I468, S469, T470, Y489, F490, P491, L492, Q493, S494, Y495, G496, F497, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive
Quantitative measurement: 0.000000304

Epitope: Epitope of nanobody Nb6 Tribody on SARS-CoV-2 S
Chemical type: Region on multi-chain protein
Discontinuous residues: A: T109, K113, A163, N164, N165, C166, T333, L335, F338, G339, F342, N343, A344, V362, D364, S366, V367, N370, A372, N388, W436, N437, S438, N439, N440, L441, D442, S443, K444, V445, G446, Q498, P499, T500, N501, V503, P507, V511, P527; B: R403, D405, E406, K417, I418, K444, G447, N448, Y449, N450, L452, I468, S469, T470, Y489, F490, P491, L492, Q493, S494, Y495, G496, F497, Q498, N501, Y505
Source molecule (GenBank): QHD43416.1
Assay category: BCell
Result: Positive