Reference: Justin F Gainor; Manish R Patel; Jeffrey S Weber; Martin Gutierrez; Julie E Bauman; Jeffrey M Clarke; Ricklie Julian; Aaron J Scott; Jessica L Geiger; Kedar Kirtane; Celine Robert-Tissot; Brandon Coder; Moomal Tasneem; Jing Sun; Wei Zheng; Lauren Gerbereux; Andressa Laino; Filippos Porichis; Jack Russella Pollard; Peijie Hou; Vasudha Sehgal; Xing Chen; Manju Morrissey; Hikmat N Daghestani; Igor Feldman; Lakshmi Srinivasan; Joshua P Frederick; Michelle Brown; Praveen Aanur; Robert Meehan; Howard A Burris. "T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study." Cancer discovery (2024).

Epitope: UTP20 p.E1943K
Chemical type: Peptide, no natural source
Sequence: IFNHELFGAVAEKKEVKQILSKVME
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: UTP20 p.E1943K
Chemical type: Peptide, no natural source
Sequence: IFNHELFGAVAEKKEVKQILSKVME
Assay category: TCell
Result: Positive-Low
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: CHIC1 p.P219S
Chemical type: Peptide, no natural source
Sequence: EYVILIEFLPKYSIFRPD
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: CHIC1 p.P219S
Chemical type: Peptide, no natural source
Sequence: EYVILIEFLPKYSIFRPD
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: BUD13 p.S240F
Chemical type: Peptide, no natural source
Sequence: PRRARHGSSDISFPRRVHNNSPDTS
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: BUD13 p.S240F
Chemical type: Peptide, no natural source
Sequence: PRRARHGSSDISFPRRVHNNSPDTS
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GPD2 p.R441W
Chemical type: Peptide, no natural source
Sequence: LITIAGGKWTTYWSMAEDTINAAVK
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: GPD2 p.R441W
Chemical type: Peptide, no natural source
Sequence: LITIAGGKWTTYWSMAEDTINAAVK
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: LASP1 p.S222F
Chemical type: Peptide, no natural source
Sequence: VYDYSAADEDEVFFQDGDTIVNVQQ
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: LASP1 p.S222F
Chemical type: Peptide, no natural source
Sequence: VYDYSAADEDEVFFQDGDTIVNVQQ
Assay category: TCell
Result: Negative
MHC allele types: 143 214 33 34 310 629 21 1078 69 1080 320 413 414 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: OR8B3 p.C169L
Chemical type: Peptide, no natural source
Sequence: TAHTGCMLRLTFLSANIINHYLCDI
Assay category: TCell
Result: Negative
MHC allele types: 142 218 252 38 1 18 69 68 774 318 407 52
Host:  67-76 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: OR8B3 p.C169L
Chemical type: Peptide, no natural source
Sequence: TAHTGCMLRLTFLSANIINHYLCDI
Assay category: TCell
Result: Positive-High
MHC allele types: 142 218 252 38 1 18 69 68 774 318 407 52
Host:  67-76 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KAT2B p.L792F
Chemical type: Peptide, no natural source
Sequence: LKNRYYVSKKLFMADFQRVFTNCKEYNPPES
Assay category: TCell
Result: Positive-High
MHC allele types: 213 252 185 1 310 18 69 13084 313 316 57 358
Host:  67-76 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: KAT2B p.L792F
Chemical type: Peptide, no natural source
Sequence: LKNRYYVSKKLFMADFQRVFTNCKEYNPPES
Assay category: TCell
Result: Negative
MHC allele types: 213 252 185 1 310 18 69 13084 313 316 57 358
Host:  67-76 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: CUBN p.R2063W
Chemical type: Peptide, no natural source
Sequence: AVLCGREIPGPIWSTGEYMFIRFTS
Assay category: TCell
Result: Negative
MHC allele types: 142 514 33 38 4 1 18 67 69 101 1024 317 515 419 413 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: CUBN p.R2063W
Chemical type: Peptide, no natural source
Sequence: AVLCGREIPGPIWSTGEYMFIRFTS
Assay category: TCell
Result: Positive-Low
MHC allele types: 142 514 33 38 4 1 18 67 69 101 1024 317 515 419 413 363
Host:  36-78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TTC3 p.F32L
Chemical type: Peptide from protein
Sequence: CPHVDDCVFAAEFMSNDYVRVTQLY
Position: 20-44
Source molecule (GenBank): H7BZ57.2
Assay category: TCell
Result: Positive-Low
MHC allele types: 142 514 33 38 4 1 18 67 69 101 1024 317 515 419 413 363
Host:  36 to 78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: TTC3 p.F32L
Chemical type: Peptide from protein
Sequence: CPHVDDCVFAAEFMSNDYVRVTQLY
Position: 20-44
Source molecule (GenBank): H7BZ57.2
Assay category: TCell
Result: Negative
MHC allele types: 142 514 33 38 4 1 18 67 69 101 1024 317 515 419 413 363
Host:  36 to 78 years
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo