Reference: Andréa Toma; Taghrid Laïka; Samy Haddouk; Sandrine Luce; Jean-Paul Briand; Luc Camoin; Francine Connan; Marion Lambert; Sophie Caillat-Zucman; Jean-Claude Carel; Sylviane Muller; Jeannine Choppin; François Lemonnier; Christian Boitard. "Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes." Diabetes (2009).

Epitope: Preproinsulin 1-8
Chemical type: Peptide from protein
Sequence: MALWMRLL
Position: 1-8
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Negative
Cell type: T cell
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: Preproinsulin 1-8
Chemical type: Peptide from protein
Sequence: MALWMRLL
Position: 1-8
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-Low

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell CD8+
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: Preproinsulin 6-14
Chemical type: Peptide from protein
Sequence: RLLPLLALL
Position: 6-14
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-High

Epitope: Preproinsulin 6-16
Chemical type: Peptide from protein
Sequence: RLLPLLALLAL
Position: 6-16
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-16
Chemical type: Peptide from protein
Sequence: RLLPLLALLAL
Position: 6-16
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-16
Chemical type: Peptide from protein
Sequence: RLLPLLALLAL
Position: 6-16
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: Preproinsulin 6-16
Chemical type: Peptide from protein
Sequence: RLLPLLALLAL
Position: 6-16
Source molecule (GenBank): ABI63346.1
Assay category: TCell
Result: Positive
Cell type: T cell
Tissue: spleen
Culture conditions: Cell Line / Clone

Epitope: Preproinsulin 6-16
Chemical type: Peptide from protein
Sequence: RLLPLLALLAL
Position: 6-16
Source molecule (GenBank): ABI63346.1
Assay category: MhcBinding
Result: Positive-High