Reference: Laura Cardoso Corrêa-Dias; Ágata Lopes-Ribeiro; Geovane Marques-Ferreira; Letícia Gomes-de-Pontes; Thaiza Aline Pereira-Santos; Erik Vinicius de Sousa Reis; Thaís de Fátima Silva Moraes; Olindo Assis Martins-Filho; Edel Figueiredo Barbosa-Stancioli; Flávio Guimarães da Fonseca; Jordana Grazziela Coelho-Dos-Reis. "HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8<sup>+</sup> T-cell-based vaccines and immunotherapies." Immunogenetics (2025).

Epitope: HCV1_peptide 16
Chemical type: Peptide from protein
Sequence: ALYDVVCKL
Position: 2594-2602
Source molecule (GenBank): A0A8A5N327
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 17
Chemical type: Peptide from protein
Sequence: ALYGAWPLL
Position: 789-797
Source molecule (GenBank): A0A068F654
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 18
Chemical type: Peptide from protein
Sequence: ALYGLWPLL
Position: 789-797
Source molecule (GenBank): A0A8A5N4S8
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 20
Chemical type: Peptide from protein
Sequence: ALYGPWPLL
Position: 789-797
Source molecule (GenBank): A0A068FB57
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 23
Chemical type: Peptide from protein
Sequence: AQPGFPWPL
Position: 77-85
Source molecule (GenBank): A0A1S6R4M1
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 53
Chemical type: Peptide from protein
Sequence: FAIKWEYVL
Position: 712-720
Source molecule (GenBank): P26663.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 54
Chemical type: Peptide from protein
Sequence: FAIKWEYVV
Position: 713-721
Source molecule (GenBank): Q9WPH5.2
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 71
Chemical type: Peptide from protein
Sequence: FVGLALLTL
Position: 823-831
Source molecule (GenBank): O93077.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 86
Chemical type: Peptide from protein
Sequence: GMGWAGWLL
Position: 90-98
Source molecule (GenBank): P26662.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 150
Chemical type: Peptide from protein
Sequence: QLDLSGWFV
Position: 2963-2971
Source molecule (GenBank): O92972.2
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 154
Chemical type: Peptide from protein
Sequence: RICACLWTM
Position: 730-738
Source molecule (GenBank): C4MRB6
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 172
Chemical type: Peptide from protein
Sequence: TIAYVLWWL
Position: 838-846
Source molecule (GenBank): A0A068F4C1
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 188
Chemical type: Peptide from protein
Sequence: VIWWLQYFL
Position: 846-854
Source molecule (GenBank): A0A068F651
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 202
Chemical type: Peptide from protein
Sequence: VLYKEFDEM
Position: 1700-1708
Source molecule (GenBank): A0A068F736
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 204
Chemical type: Peptide from protein
Sequence: VLYREFDEM
Position: 1700-1708
Source molecule (GenBank): A8DG50.2
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 230
Chemical type: Peptide from protein
Sequence: YISWCFWWL
Position: 838-846
Source molecule (GenBank): Q9DIT6.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 233
Chemical type: Peptide from protein
Sequence: YLEQGMHLA
Position: 1717-1725
Source molecule (GenBank): A0A023JCV7.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV1_peptide 238
Chemical type: Peptide from protein
Sequence: YTVYGIWPL
Position: 788-796
Source molecule (GenBank): C4MRB7
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 2
Chemical type: Peptide from protein
Sequence: ALLRICALV
Position: 921-929
Source molecule (GenBank): T2C799
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 17
Chemical type: Peptide from protein
Sequence: CLWWLPYLL
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 29
Chemical type: Peptide from protein
Sequence: DVWDWICTI
Position: 1984-1992
Source molecule (GenBank): A0A1S6R321
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 30
Chemical type: Peptide from protein
Sequence: EIMTSTWVL
Position: 1658-1666
Source molecule (GenBank): Q7T7H3.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 38
Chemical type: Peptide from protein
Sequence: FLGTSISGV
Position: 1073-1081
Source molecule (GenBank): P26661.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 45
Chemical type: Peptide from protein
Sequence: FVQDCNCSV
Position: 300-308
Source molecule (GenBank): E6Z7K4
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 55
Chemical type: Peptide from protein
Sequence: GMWSFFLLL
Position: 796-804
Source molecule (GenBank): I3PN90
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 75
Chemical type: Peptide from protein
Sequence: LIQEWVPPL
Position: 860-868
Source molecule (GenBank): Q6GYR8.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 82
Chemical type: Peptide from protein
Sequence: LLGLWSFAL
Position: 794-802
Source molecule (GenBank): A0A866W2J1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 89
Chemical type: Peptide from protein
Sequence: LLRDALTRV
Position: 905-913
Source molecule (GenBank): A0A0E3IRR6
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 110
Chemical type: Peptide from protein
Sequence: QAYAYEASV
Position: 810-818
Source molecule (GenBank): Q9Q9B0.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 117
Chemical type: Peptide from protein
Sequence: RCLWWLLYL
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 118
Chemical type: Peptide from protein
Sequence: RCLWWLPYL
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 135
Chemical type: Peptide from protein
Sequence: SLWWLCYLL
Position: 846-854
Source molecule (GenBank): A0AA49BQG6
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 137
Chemical type: Peptide from protein
Sequence: SLWWLSYML
Position: 846-854
Source molecule (GenBank): Q7T7J1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 138
Chemical type: Peptide from protein
Sequence: SLWWTCYLL
Position: 846-854
Source molecule (GenBank): A0A0E3IS34
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 150
Chemical type: Peptide from protein
Sequence: VLYEAFDEM
Position: 1704-1712
Source molecule (GenBank): A0A2I6PIY1.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 159
Chemical type: Peptide from protein
Sequence: WLSDIWDWV
Position: 1980-1988
Source molecule (GenBank): A0A1S6R344
Assay category: MhcBinding
Result: Positive

Epitope: HCV2_peptide 169
Chemical type: Peptide from protein
Sequence: YMVRWEWII
Position: 721-729
Source molecule (GenBank): T2C7A4
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 2
Chemical type: Peptide from protein
Sequence: AAMENLVVL
Position: 752-760
Source molecule (GenBank): A0A076G241
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 7
Chemical type: Peptide from protein
Sequence: AVLGPLYLV
Position: 901-909
Source molecule (GenBank): A0A076G2Y3
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 11
Chemical type: Peptide from protein
Sequence: DIWDWVCTV
Position: 1985-1993
Source molecule (GenBank): A0A023JCM2
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 15
Chemical type: Peptide from protein
Sequence: FLVCGDDLV
Position: 2743-2751
Source molecule (GenBank): Q81258.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 18
Chemical type: Peptide from protein
Sequence: FVVLIFLLL
Position: 724-732
Source molecule (GenBank): A0A076G8Q3
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 35
Chemical type: Peptide from protein
Sequence: LALFGFFTL
Position: 829-837
Source molecule (GenBank): D2IRM6.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 43
Chemical type: Peptide from protein
Sequence: LLSCLIHPA
Position: 181-189
Source molecule (GenBank): A0A385NHT8.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 44
Chemical type: Peptide from protein
Sequence: LLSCLLCPA
Position: 181-189
Source molecule (GenBank): A0A076G2T2
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 66
Chemical type: Peptide from protein
Sequence: SLMAFTASV
Position: 1795-1803
Source molecule (GenBank): Q81258.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 76
Chemical type: Peptide from protein
Sequence: TLSDFRTWL
Position: 1993-2001
Source molecule (GenBank): A0A1S6R421.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 81
Chemical type: Peptide from protein
Sequence: VALWLMMMV
Position: 742-750
Source molecule (GenBank): F2VHR0.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 87
Chemical type: Peptide from protein
Sequence: VLLVLCLFA
Position: 371-379
Source molecule (GenBank): A0A087VSD2
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 92
Chemical type: Peptide from protein
Sequence: VVFCAAWHV
Position: 776-784
Source molecule (GenBank): A0A076G8Q3
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 98
Chemical type: Peptide from protein
Sequence: YLIQAAITT
Position: 909-917
Source molecule (GenBank): F2VHR0.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV3_peptide 99
Chemical type: Peptide from protein
Sequence: YLYGVGAGM
Position: 707-715
Source molecule (GenBank): A0A1S6R441
Assay category: MhcBinding
Result: Positive

Epitope: HCV4_peptide 12
Chemical type: Peptide from protein
Sequence: FGLDPTFSI
Position: 1463-1471
Source molecule (GenBank): A0A193BIY3
Assay category: MhcBinding
Result: Positive

Epitope: HCV5_peptide 21
Chemical type: Peptide from protein
Sequence: GQPGYPWPL
Position: 77-85
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV5_peptide 23
Chemical type: Peptide from protein
Sequence: ILAGYGTGV
Position: 1852-1860
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV5_peptide 30
Chemical type: Peptide from protein
Sequence: LLVCGDDLV
Position: 2736-2744
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV5_peptide 44
Chemical type: Peptide from protein
Sequence: VLIDILAGY
Position: 1848-1856
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV5_peptide 48
Chemical type: Peptide from protein
Sequence: WLGNIIMYA
Position: 2831-2839
Source molecule (GenBank): O39928.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV6_peptide 5
Chemical type: Peptide from protein
Sequence: ALLVLTIFT
Position: 827-835
Source molecule (GenBank): O92529.3
Assay category: MhcBinding
Result: Positive

Epitope: HCV6_peptide 14
Chemical type: Peptide from protein
Sequence: FQPRRHWTV
Position: 294-302
Source molecule (GenBank): B9V0E2.1
Assay category: MhcBinding
Result: Positive

Epitope: HCV6_peptide 25
Chemical type: Peptide from protein
Sequence: HLAGCVPCV
Position: 222-230
Source molecule (GenBank): A0A0B5G942
Assay category: MhcBinding
Result: Positive

Epitope: HCV6_peptide 47
Chemical type: Peptide from protein
Sequence: SMMSFTGSL
Position: 1795-1803
Source molecule (GenBank): Q1KL31
Assay category: MhcBinding
Result: Positive

Epitope: HCV7_peptide 31
Chemical type: Peptide from protein
Sequence: VMMCPLYLL
Position: 898-906
Source molecule (GenBank): A8QPD9.1
Assay category: MhcBinding
Result: Positive