Reference: Ronit Mazor; Jaime A Eberle; Xiaobo Hu; Aaron N Vassall; Masanori Onda; Richard Beers; Elizabeth C Lee; Robert J Kreitman; Byungkook Lee; David Baker; Chris King; Raffit Hassan; Itai Benhar; Ira Pastan. "Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes." Proceedings of the National Academy of Sciences of the United States of America (2014).

Epitope: Peptide 23
Chemical type: Peptide from protein
Sequence: SPGSGGDLGEAIREQ
Position: 343-357
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 23
Chemical type: Peptide from protein
Sequence: SPGSGGDLGEAIREQ
Position: 343-357
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 34
Chemical type: Peptide from protein
Sequence: VRQGTGNDEAGAANG
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 34
Chemical type: Peptide from protein
Sequence: VRQGTGNDEAGAANG
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 36
Chemical type: Peptide from protein
Sequence: NDEAGAANGPADSGD
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 36
Chemical type: Peptide from protein
Sequence: NDEAGAANGPADSGD
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 53
Chemical type: Peptide from protein
Sequence: QAHRQLEERGYVFVG
Position: 449-463
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 53
Chemical type: Peptide from protein
Sequence: QAHRQLEERGYVFVG
Position: 449-463
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 61
Chemical type: Peptide from protein
Sequence: QSIVFGGVRARSQDL
Position: 473-487
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 61
Chemical type: Peptide from protein
Sequence: QSIVFGGVRARSQDL
Position: 473-487
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 80
Chemical type: Peptide from protein
Sequence: RSSLPGFYRTSLTLA
Position: 530-544
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 80
Chemical type: Peptide from protein
Sequence: RSSLPGFYRTSLTLA
Position: 530-544
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 84
Chemical type: Peptide from protein
Sequence: TLAAPEAAGEVERLI
Position: 542-556
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 84
Chemical type: Peptide from protein
Sequence: TLAAPEAAGEVERLI
Position: 542-556
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 105
Chemical type: Peptide from protein
Sequence: GDLDPSSIPDKEQAI
Position: 605-619
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 105
Chemical type: Peptide from protein
Sequence: GDLDPSSIPDKEQAI
Position: 605-619
Source molecule (GenBank): AAB59097.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 77 R500A
Chemical type: Peptide, no natural source
Sequence: GALLAVYVPRSSLPG
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 77 G510A
Chemical type: Peptide, no natural source
Sequence: GALLRVYVPRSSLPA
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 93-94 I555A
Chemical type: Peptide, no natural source
Sequence: GPEEEGGRLETALGWPLA
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 76 V503A
Chemical type: Peptide, no natural source
Sequence: IRNGALLRVYAPRSS
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 76 S506A
Chemical type: Peptide, no natural source
Sequence: IRNGALLRVYVPRAS
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 51 R432A
Chemical type: Peptide, no natural source
Sequence: TVERLLQAHRQLEEA
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 67 L477A
Chemical type: Peptide, no natural source
Sequence: WRGFYIAGDPAAAYG
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 57-58 F436A
Chemical type: Peptide, no natural source
Sequence: AVGYHGTFLEAAQSIVFG
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: Peptide 57-58 F443A
Chemical type: Peptide, no natural source
Sequence: FVGYHGTALEAAQSIVFG
Assay category: TCell
Result: Positive-Low
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated