Reference: Katharina N Steinitz; Pauline M van Helden; Brigitte Binder; David C Wraith; Sabine Unterthurner; Corinna Hermann; Maria Schuster; Rafi U Ahmad; Markus Weiller; Christian Lubich; Maurus de la Rosa; Hans Peter Schwarz; Birgit M Reipert. "CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice." Blood (2012).

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive-Low
Quantitative measurement: 2261.4

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 713.4

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 525.0

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 785.4

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 246.0

Epitope: FVIII P13
Chemical type: Peptide from protein
Sequence: LLIIFKNQASRPYNI
Position: 480-494
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 547.2

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Negative

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Negative

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 52.2

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 7200.0

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Positive-High
Quantitative measurement: 624.0

Epitope: FVIII P18
Chemical type: Peptide from protein
Sequence: QANRSPLPIAKVSSF
Position: 1401-1415
Source molecule (GenBank): AAA52484.1
Assay category: MhcBinding
Result: Negative
Quantitative measurement: 7200.0

Epitope: FVIII (455-474)
Chemical type: Peptide from protein
Sequence: GEVGDTLLIIFKNQASRPYN
Position: 474-493
Source molecule (GenBank): AAA52484.1
Assay category: TCell
Result: Positive-Low
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)

Epitope: FVIII (1766-1786)
Chemical type: Peptide from protein
Sequence: EVEDNIMVTFRNQASRPYSFY
Position: 1785-1805
Source molecule (GenBank): AAA52484.1
Assay category: TCell
Result: Positive-High
Host:  8-12 weeks
Cell type: T cell CD4+
Tissue: spleen
Culture conditions: Cell Line / Clone (Hybridoma)