Reference: David Arribas-Layton; Perrin Guyer; Thomas Delong; Mylinh Dang; I-Ting Chow; Cate Speake; Carla J Greenbaum; William W Kwok; Rocky L Baker; Kathryn Haskins; Eddie A James. "Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01." Diabetes (2020).

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Direct Ex Vivo

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive-Low
Host:  21-64 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: TCell
Result: Positive
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.2
Chemical type: Spliced peptide from proteins
Position: 10-17
Source molecule (GenBank): 2WRU_B
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 440.0

Epitope: HIP-4.6
Chemical type: Spliced peptide from proteins
Position: 20-27
Source molecule (GenBank): 4EFX_B
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 4500.0

Epitope: HIP-4.13
Chemical type: Spliced peptide from proteins
Position: 19-26
Source molecule (GenBank): 4EFX_B
Assay category: MhcBinding
Result: Negative

Epitope: HIP-4.17
Chemical type: Spliced peptide from proteins
Position: 13-20
Source molecule (GenBank): 2WRU_B
Assay category: MhcBinding
Result: Negative

Epitope: HIP-4.21
Chemical type: Spliced peptide from proteins
Position: 34-41
Source molecule (GenBank): F8WCM5.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1000.0

Epitope: HIP-4.24
Chemical type: Spliced peptide from proteins
Position: 5-12
Source molecule (GenBank): 2WRU_B
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1500.0

Epitope: HIP-4.4L
Chemical type: Peptide from protein
Sequence: ICSLYQLENYCN
Position: 6-17
Source molecule (GenBank): 2W44_A
Assay category: TCell
Result: Negative
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.4L
Chemical type: Peptide from protein
Sequence: ICSLYQLENYCN
Position: 6-17
Source molecule (GenBank): 2W44_A
Assay category: MhcBinding
Result: Negative

Epitope: HIP-4.1-4.2-4.18R
Chemical type: Peptide from protein
Sequence: KQASAIKKEELVARSE
Position: 203-218
Source molecule (GenBank): NP_001810.2
Assay category: TCell
Result: Negative
Host:  16-39 years
Cell type: T cell CD4+
Tissue: blood
Culture conditions: Cell Line / Clone

Epitope: HIP-4.1-4.2-4.18R
Chemical type: Peptide from protein
Sequence: KQASAIKKEELVARSE
Position: 203-218
Source molecule (GenBank): NP_001810.2
Assay category: MhcBinding
Result: Negative

Epitope: HIP-4.4R4
Chemical type: Peptide, no natural source
Sequence: ICSRYQLEFVNQHLCG
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 9700.0

Epitope: HIP-4.4 R7
Chemical type: Peptide, no natural source
Sequence: ICSLYQREFVNQHLCG
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 16000.0