Reference: Jinmin Tian; Bingli Shang; Jianing Zhang; Yuanyuan Guo; Min Li; Yuechao Hu; Dan Bai; Junying She; Yang Han; Peipei Guo; Mengkun Huang; Yalan Wang; Maoshun Liu; Jie Zhang; Beiwei Ye; Yaxin Guo; Mengjie Yang; Ying Lin; Ting Zhang; Xin Sun; Xiaoju Yuan; Danni Zhang; Ziqian Xu; Yan Chai; Jianxun Qi; Kefang Liu; Shuguang Tan; Yingze Zhao; Jikun Zhou; Rui Song; George F Gao; Jun Liu. "T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots." Nature immunology (2025).

Epitope: LLLDRLNKL BA.2.86/JN.1
Chemical type: Peptide from protein
Sequence: LLLDRLNKL
Position: 219-227
Source molecule (GenBank): WOO66090.1
Assay category: TCell
Result: Positive-Low
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: LLLDRLNKL BA.2.86/JN.1
Chemical type: Peptide from protein
Sequence: LLLDRLNKL
Position: 219-227
Source molecule (GenBank): WOO66090.1
Assay category: MhcBinding
Result: Positive

Epitope: LLLDRLNKL BA.2.86/JN.1
Chemical type: Peptide from protein
Sequence: LLLDRLNKL
Position: 219-227
Source molecule (GenBank): WOO66090.1
Assay category: MhcBinding
Result: Positive
Quantitative measurement: 1.96

Epitope: S 325-342
Chemical type: Peptide from protein
Sequence: SIVRFPNITNLCPFGEVF
Position: 325-342
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 393-410
Chemical type: Peptide from protein
Sequence: TNVYADSFVIRGDEVRQI
Position: 393-410
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 431-445
Chemical type: Peptide from protein
Sequence: GCVIAWNSNNLDSKV
Position: 431-445
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 442-458
Chemical type: Peptide from protein
Sequence: DSKVGGNYNYLYRLFRK
Position: 442-458
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 465-482
Chemical type: Peptide from protein
Sequence: ERDISTEIYQAGSTPCNG
Position: 465-482
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 567-584
Chemical type: Peptide from protein
Sequence: RDIADTTDAVRDPQTLEI
Position: 567-584
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 928-945
Chemical type: Peptide from protein
Sequence: NSAIGKIQDSLSSTASAL
Position: 928-945
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 1128-1145
Chemical type: Peptide from protein
Sequence: VVIGIVNNTVYDPLQPEL
Position: 1128-1145
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: M 91-107
Chemical type: Peptide from protein
Sequence: MWLSYFIASFRLFARTR
Position: 91-107
Source molecule (GenBank): P0DTC5.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: N 218-234
Chemical type: Peptide from protein
Sequence: ALALLLLDRLNQLESKM
Position: 218-234
Source molecule (GenBank): P0DTC9.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 352-369 BA.2.86
Chemical type: Peptide from protein
Sequence: AWNRTRISNCVADYSVLY
Position: 349-366
Source molecule (GenBank): WWD53912.1
Assay category: TCell
Result: Positive
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 50-58
Chemical type: Peptide from protein
Sequence: STQDLFLPF
Position: 50-58
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 151-159
Chemical type: Peptide from protein
Sequence: SWMESEFRV
Position: 151-159
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 216-223
Chemical type: Peptide from protein
Sequence: LPQGFSAL
Position: 216-223
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 216-226
Chemical type: Peptide from protein
Sequence: LPQGFSALEPL
Position: 216-226
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 240-248
Chemical type: Peptide from protein
Sequence: TLLALHRSY
Position: 240-248
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 351-358
Chemical type: Peptide from protein
Sequence: YAWNRKRI
Position: 351-358
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 394-403
Chemical type: Peptide from protein
Sequence: NVYADSFVIR
Position: 394-403
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated

Epitope: S 454-462
Chemical type: Peptide from protein
Sequence: RLFRKSNLK
Position: 454-462
Source molecule (GenBank): P0DTC2.1
Assay category: TCell
Result: Negative
Cell type: PBMC
Tissue: blood
Culture conditions: Short Term Restimulated